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https://www.readbyqxmd.com/read/28227795/simplified-realistic-human-head-model-for-simulating-tumor-treating-fields-ttfields
#1
Cornelia Wenger, Ze'ev Bomzon, Ricardo Salvador, Peter J Basser, Pedro C Miranda, Cornelia Wenger, Ze'ev Bomzon, Ricardo Salvador, Peter J Basser, Pedro C Miranda, Peter J Basser, Pedro C Miranda, Cornelia Wenger, Ricardo Salvador, Ze'ev Bomzon
Tumor Treating Fields (TTFields) are alternating electric fields in the intermediate frequency range (100-300 kHz) of low-intensity (1-3 V/cm). TTFields are an anti-mitotic treatment against solid tumors, which are approved for Glioblastoma Multiforme (GBM) patients. These electric fields are induced non-invasively by transducer arrays placed directly on the patient's scalp. Cell culture experiments showed that treatment efficacy is dependent on the induced field intensity. In clinical practice, a software called NovoTal(TM) uses head measurements to estimate the optimal array placement to maximize the electric field delivery to the tumor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227684/a-novel-wireless-wearable-fluorescence-image-guided-surgery-system
#2
Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian, Kunshan He, Yamin Mao, Jinzuo Ye, Yu An, Shixin Jiang, Chongwei Chi, Jie Tian, Shixin Jiang, Jinzuo Ye, Kunshan He, Chongwei Chi, Jie Tian, Yamin Mao, Yu An
Segmentectomy using indocyanine green (ICG) has become a primary treatment option to achieve a complete resection and preserve lung function in early-stage lung cancer. However, owing to a lack of appropriate intraoperative imaging systems, it is a huge challenge for surgeons to identify the intersegmental plane during the operation, leading to poor prognosis. Thus, we developed a novel wireless wearable fluorescence image-guided surgery system (LIGHTEN) for fast and accurate identification of intersegmental planes in human patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227510/feasibility-of-an-ultra-low-power-digital-signal-processor-platform-as-a-basis-for-a-fully-implantable-brain-computer-interface-system
#3
Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, Po T Wang, Keulanna Gandasetiawan, Colin M McCrimmon, Alireza Karimi-Bidhendi, Charles Y Liu, Payam Heydari, Zoran Nenadic, An H Do, An H Do, Zoran Nenadic, Colin M McCrimmon, Keulanna Gandasetiawan, Payam Heydari, Alireza Karimi-Bidhendi, Po T Wang, Charles Y Liu
A fully implantable brain-computer interface (BCI) can be a practical tool to restore independence to those affected by spinal cord injury. We envision that such a BCI system will invasively acquire brain signals (e.g. electrocorticogram) and translate them into control commands for external prostheses. The feasibility of such a system was tested by implementing its benchtop analogue, centered around a commercial, ultra-low power (ULP) digital signal processor (DSP, TMS320C5517, Texas Instruments). A suite of signal processing and BCI algorithms, including (de)multiplexing, Fast Fourier Transform, power spectral density, principal component analysis, linear discriminant analysis, Bayes rule, and finite state machine was implemented and tested in the DSP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227373/comparative-study-of-texture-features-in-oct-images-at-different-scales-for-human-breast-tissue-classification
#4
Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Yu Gan, Xinwen Yao, Ernest Chang, Syed Bin Amir, Hanina Hibshoosh, Sheldon Feldman, Christine P Hendon, Syed Bin Amir, Christine P Hendon, Sheldon Feldman, Yu Gan, Hanina Hibshoosh, Ernest Chang, Xinwen Yao
Breast cancer is the second leading cause of death in women in the United States due to cancer. Early detection of breast cancerous regions will aid the diagnosis, staging, and treatment of breast cancer. Optical coherence tomography (OCT), a non-invasive imaging modality with high resolution, has been widely used to visualize various tissue types within the human breast and has demonstrated great potential for assessing tumor margins. Imaging large resected samples with a fast imaging speed can be accomplished by under-sampling in the spatial domain, resulting in a large image scale...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227057/mobile-interface-for-neuroprosthesis-control-aiming-tetraplegic-users
#5
Renato G Barelli, Plinio T Aquino, Maria Claudia Ferrari de Castro, Renato G Barelli, Plinio T Aquino Junior, Maria Claudia Ferrari de Castro, Plinio T Aquino, Maria Claudia Ferrari de Castro, Renato G Barelli
This article proposes the development of a mobile interface for controlling a Neuroprosthesis, designed to restore grasp patterns, aiming tetraplegics users at C5 and C6 levels. Human Computer Interface paradigms and usability concepts guide its planning and development to garantee the quality of user's interaction with the system and thus, the sucess and controlability of the neuroprostheses. The number of screens and menus were optimized, thus the user may feel the interface as more intuitive, leading to fast learning and increasing the trust on it...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225463/doctors-without-borders
#6
Val Wass, Lesley Southgate
The unprecedented demands of patient and population priorities created by globalization and escalating health and social inequities will not be met unless medical education changes. Educators have failed to move fast enough to create an education framework that meets current population needs. A new common set of professional values around global social accountability is necessary. Education borders must be broken down at three levels-societal-institutional, interpersonal, and individual.At a societal-institutional level, global health must be embraced as part of a philosophy of population needs, human rights, equity, and justice...
February 21, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28224247/a-simplified-lc-ms-ms-method-for-rapid-determination-of-cycloserine-in-small-volume-human-plasma-using-protein-precipitation-coupled-with-dilution-techniques-to-overcome-matrix-effects-and-its-application-to-a-pharmacokinetic-study
#7
Zhengsheng Mao, Xin Wang, Bingxin Li, Jing Jin, Ming Xu, Youping Liu, Xin Di
Matrix effects have been a major concern when developing LC-MS/MS methods for quantitative bioanalysis of cycloserine. Sample handling procedures including solid phase extraction or derivatization have been reported previously by researchers to overcome matrix effects of cycloserine. In the present study, the possibility of reducing matrix effects of cycloserine using protein precipitation coupled with dilution techniques was investigated. Plasma samples were pretreated by protein precipitation with methanol followed by a 40-fold dilution with methanol-water (50:50, v/v)...
February 21, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28223291/ctrp7-deletion-attenuates-obesity-linked-glucose-intolerance-adipose-tissue-inflammation-and-hepatic-stress
#8
Pia S Petersen, Xia Lei, Risa M Wolf, Susana Rodriguez, Stefanie Y Tan, Hannah C Little, Michael A Schweitzer, Thomas H Magnuson, Kimberley E Steele, G William Wong
Chronic low-grade inflammation and cellular stress are important contributors to obesity-linked metabolic dysfunction. Here, we uncover an immune-metabolic role for C1q/TNF-related protein 7 (CTRP7), a secretory protein of the C1q family with previously unknown function. In obese humans, circulating CTRP7 levels were markedly elevated and positively correlated with BMI, glucose, insulin, insulin resistance index, hemoglobin A1c, and triglyceride levels. Expression of CTRP7 in liver was also significantly upregulated in obese humans and positively correlated with gluconeogenic genes...
February 21, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28222742/resistant-starch-lowers-postprandial-glucose-and-leptin-in-overweight-adults-consuming-a-moderate-to-high-fat-diet-a-randomized-controlled-trial
#9
Mindy Patterson Maziarz, Sara Preisendanz, Shanil Juma, Victorine Imrhan, Chandan Prasad, Parakat Vijayagopal
BACKGROUND: High-amylose maize resistant starch type 2 (HAM-RS2) stimulates gut-derived satiety peptides and reduces adiposity in animals. Human studies have not supported these findings despite improvements in glucose homeostasis and insulin sensitivity after HAM-RS2 intake which can lower adiposity-related disease risk. The primary objective of this study was to evaluate the impact of HAM-RS2 consumption on blood glucose homeostasis in overweight, healthy adults. We also examined changes in biomarkers of satiety (glucagon-like peptide-1 [GLP-1], peptide YY [PYY], and leptin) and body composition determined by anthropometrics and dual-energy x-ray absorptiometry, dietary intake, and subjective satiety measured by a visual analogue scale following HAM-RS2 consumption...
February 21, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28221956/microbiological-quality-and-occurrence-of-nontuberculous-mycobacteria-in-fresh-squeezed-orange-juice-samples-purchased-from-street-vendors-in-mexico-city
#10
Jorge F Cerna-Cortes, Ana Laura Cortes-Cueto, Maria Rosalia Cano-Gaona, Nancy Leon-Montes, Addy C Helguera-Repetto, Sandra Rivera-Gutierrez, Laura P Salas-Rangel, Javier Castro-Rosas, Jorge A Gonzalez-Y-Merchand
Nontuberculous mycobacteria (NTM) are potentially pathogenic agents commonly found in a natural ecosystem. For this reason, food is considered another source of NTM transmission for humans. The aims of this study were to evaluate the microbiological quality and the occurrence of NTM in fresh-squeezed orange juice samples purchased from street vendors. All 102 samples analyzed were positive for aerobic mesophilic bacteria (AMB), with limits ranging from 1.8 to 6.2 log CFU/ml. A total of 55 (54%), 25 (25%), and 13 (13%) orange juice samples were positive for total coliforms (TC), fecal coliforms (FC), and Escherichia coli , respectively...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221365/glial-glt-1-blockade-in-infralimbic-cortex-as-a-new-strategy-to-evoke-rapid-antidepressant-like-effects-in-rats
#11
J Gasull-Camós, M Tarrés-Gatius, F Artigas, A Castañé
Ketamine and deep brain stimulation produce rapid antidepressant effects in humans and rodents. An increased AMPA receptor (AMPA-R) signaling in medial prefrontal cortex (mPFC) has been suggested to mediate these responses. However, little research has addressed the direct effects of enhancing glutamate tone or AMPA-R stimulation in mPFC subdivisions. The current study investigates the behavioral and neurochemical consequences of glutamate transporter-1 (GLT-1) blockade or s-AMPA microinfusion in the infralimbic (IL) and prelimbic (PrL) cortex...
February 21, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28221112/variegated-squirrel-bornavirus-1-in-squirrels-germany-and-the-netherlands
#12
Kore Schlottau, Maria Jenckel, Judith van den Brand, Christine Fast, Christiane Herden, Dirk Höper, Timo Homeier-Bachmann, Jens Thielebein, Niels Mensing, Bert Diender, Donata Hoffmann, Rainer G Ulrich, Thomas C Mettenleiter, Marion Koopmans, Dennis Tappe, Jonas Schmidt-Chanasit, Chantal B E M Reusken, Martin Beer, Bernd Hoffmann
We screened squirrels in Germany and the Netherlands for the novel zoonotic variegated squirrel bornavirus 1 (VSBV-1). The detection of VSBV-1 in 11 squirrels indicates a considerable risk for transmission to humans handling those animals. Therefore, squirrels in contact with humans should routinely be tested for VSBV-1.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28220384/human-exposure-to-perfluoroalkyl-substances-near-a-fluorochemical-industrial-park-in-china
#13
Jia Bao, Li Liu, Xin Wang, Yi-He Jin, Guang-Hui Dong
Severe perfluoroalkyl substance (PFAS) contaminations have been observed in both surface water and groundwater in the vicinity of Fuxin, China, over the past years, attributing to the fast-growing fluorochemical industries locally. However, little is known about the overall daily intake of PFAS contaminations by Fuxin residents recently. In the present study, ten target PFAS analytes in the blood serum samples collected from 100 non-occupationally exposed healthy residents in Fuxin, with an average age of 47...
February 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28220124/in-vivo-efficacy-of-umbilical-cord-blood-stem-cell-derived-nk-cells-in-the-treatment-of-metastatic-colorectal-cancer
#14
John P Veluchamy, Silvia Lopez-Lastra, Jan Spanholtz, Fenna Bohme, Nina Kok, Daniëlle A M Heideman, Henk M W Verheul, James P Di Santo, Tanja D de Gruijl, Hans J van der Vliet
Therapeutic monoclonal antibodies against the epidermal growth factor receptor (EGFR) act by inhibiting EGFR downstream signaling and by eliciting a natural killer (NK) cell-mediated antitumor response. The IgG1 mAb cetuximab has been used for treatment of RAS(wt) metastatic colorectal cancer (mCRC) patients, showing limited efficacy. In the present study, we address the potential of adoptive NK cell therapy to overcome these limitations investigating two allogeneic NK cell products, i.e., allogeneic activated peripheral blood NK cells (A-PBNK) and umbilical cord blood stem cell-derived NK cells (UCB-NK)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28219984/motor-neurons-tune-premotor-activity-in-a-vertebrate-central-pattern-generator
#15
Kristy J Lawton, Wick M Perry, Ayako Yamaguchi, Erik Zornik
Central patterns generators (CPGs) are neural circuits that drive rhythmic motor output without sensory feedback. Vertebrate CPGs are generally believed to operate in a top-down manner in which premotor interneurons activate motor neurons that in turn drive muscles. In contrast, the frog (Xenopus laevis) vocal CPG contains a functionally unexplored neuronal projection from the motor nucleus to the premotor nucleus, indicating a recurrent pathway that may contribute to rhythm generation. In this study we characterized the function of this bottom-up connection...
February 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28219828/treating-cognitive-impairment-with-transcranial-low-level-laser-therapy
#16
Jack C de la Torre
This report examines the potential of low level laser therapy (LLLT) to alter brain cell function and neurometabolic pathways using red or near infrared (NIR) wavelengths transcranially for the prevention and treatment of cognitive impairment. Although laser therapy on human tissue has been used for a number of medical conditions since the late 1960s, it is only recently that several clinical studies have shown its value in raising neurometabolic energy levels that can improve cerebral hemodynamics and cognitive abilities in humans...
February 13, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28219432/personalized-heterogeneous-deformable-model-for-fast-volumetric-registration
#17
Weixin Si, Xiangyun Liao, Qiong Wang, Pheng Ann Heng
BACKGROUND: Biomechanical deformable volumetric registration can help improve safety of surgical interventions by ensuring the operations are extremely precise. However, this technique has been limited by the accuracy and the computational efficiency of patient-specific modeling. METHODS: This study presents a tissue-tissue coupling strategy based on penalty method to model the heterogeneous behavior of deformable body, and estimate the personalized tissue-tissue coupling parameters in a data-driven way...
February 20, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28218439/the-effects-of-exogenous-fatty-acids-and-niacin-on-human-monocyte-macrophage-plasticity
#18
Sergio Montserrat-de la Paz, Dolores Rodriguez, Magdalena P Cardelo, Maria C Naranjo, Beatriz Bermudez, Rocio Abia, Francisco J G Muriana, Sergio Lopez
SCOPE: Macrophage plasticity allows adapting to different environments, having a dual activity in inflammatory-related diseases. Our hypothesis is that the type of dietary fatty acids into human postprandial triglyceride-rich lipoproteins (TRLs), alone or in combination with niacin (vitamin B3), could modulate the plasticity of monocytes-macrophages. METHODS AND RESULTS: We isolated TRLs at the postprandial peak from blood samples of healthy volunteers after the ingestion of a meal rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) or MUFAs plus omega-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28216670/intraluminal-pressure-patterns-in-the-human-colon-assessed-by-high-resolution-manometry
#19
Ji-Hong Chen, Yuanjie Yu, Zixian Yang, Wen-Zhen Yu, Wu Lan Chen, Hui Yu, Marie Jeong-Min Kim, Min Huang, Shiyun Tan, Hesheng Luo, Jianfeng Chen, Jiande D Z Chen, Jan D Huizinga
Assessment of colonic motor dysfunction is rarely done because of inadequate methodology and lack of knowledge about normal motor patterns. Here we report on elucidation of intraluminal pressure patterns using High Resolution Colonic Manometry during a baseline period and in response to a meal, in 15 patients with constipation, chronically dependent on laxatives, 5 healthy volunteers and 9 patients with minor, transient, IBS-like symptoms but no sign of constipation. Simultaneous pressure waves (SPWs) were the most prominent propulsive motor pattern, associated with gas expulsion and anal sphincter relaxation, inferred to be associated with fast propagating contractions...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216610/pulmonary-kaposi-sarcoma-with-osseous-metastases-in-an-human-immunodeficiency-virus-hiv-patient-a-remarkable-response-to-highly-active-antiretroviral-therapy
#20
Ahmed Dirweesh, Muhammad Yasir Khan, Shaikh Fawad Hamiz, Nigahus Karabulut
BACKGROUND Kaposi sarcoma (KS) is known to involve the mucocutaneous tissues and the aero-digestive tracts. In acquired immune deficiency syndrome (AIDS) patients, KS has an aggressive course and carries poor prognosis. We present a case of pulmonary KS with osseous metastases as the first presentation of human immunodeficiency virus (HIV) infection in a young male. The lesions impressively decreased in size and numbers following initiation of highly active antiretroviral therapy (HAART). CASE REPORT A 34-year-old heterosexual male presented with a one month history of cough and 15-20 pound weight loss within six months...
February 20, 2017: American Journal of Case Reports
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