Maik Pietzner, Burulça Uluvar, Kristoffer J Kolnes, Per B Jeppesen, S Victoria Frivold, Øyvind Skattebo, Egil I Johansen, Bjørn S Skålhegg, Jørgen F P Wojtaszewski, Anders J Kolnes, Giles S H Yeo, Stephen O'Rahilly, Jørgen Jensen, Claudia Langenberg
Surviving long periods without food has shaped human evolution. In ancient and modern societies, prolonged fasting was/is practiced by billions of people globally for religious purposes, used to treat diseases such as epilepsy, and recently gained popularity as weight loss intervention, but we still have a very limited understanding of the systemic adaptions in humans to extreme caloric restriction of different durations. Here we show that a 7-day water-only fast leads to an average weight loss of 5.7 kg (±0...
March 1, 2024: Nature metabolism