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https://www.readbyqxmd.com/read/29239294/demographics-interests-and-quality-of-life-of-canadian-neurosurgery-residents
#1
Christian Iorio-Morin, Syed Uzair Ahmed, Mark Bigder, Ayoub Dakson, Cameron Elliott, Daipayan Guha, Michelle Kameda-Smith, Pascal Lavergne, Serge Makarenko, Michael S Taccone, Michael K Tso, Bill Wang, Alexander Winkler-Schwartz, David Fortin
BACKGROUND: Neurosurgical residents face a unique combination of challenges, including long duty hours, technically challenging cases, and uncertain employment prospects. We sought to assess the demographics, interests, career goals, self-rated happiness, and overall well-being of Canadian neurosurgery residents. METHODS: A cross-sectional survey was developed and sent through the Canadian Neurosurgery Research Collaborative to every resident enrolled in a Canadian neurosurgery program as of April 1, 2016...
December 14, 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29238393/influence-of-severe-carotid-stenosis-on-cognition-depressive-symptoms-and-quality-of-life
#2
Elina Pucite, Ildze Krievina, Evija Miglane, Renars Erts, Dainis Krievins
Background: Carotid artery disease is not just a causal risk factor of ischemic stroke, but may predispose patients to depressive symptoms and low health related quality of life (HRQoL). Objectives: The objectives of the present study were to assess the association between severe carotid artery stenosis (CAS) and cognitive impairment, frequency of depressive symptoms and status of HRQoL. Methods: Cross - sectional study involved 55 patients with severe CAS and 54 patients with lower extremity peripheral artery disease (PAD)...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29228215/mitochondria-are-critical-for-bdnf-mediated-synaptic-and-vascular-plasticity-of-hippocampus-following-repeated-electroconvulsive-seizures
#3
Fenghua Chen, Maryam Ardalan, Betina Elfving, Gregers Wegener, Torsten M Madsen, Jens R Nyengaard
Background: Electroconvulsive therapy (ECT) is a fast acting and efficient treatment of depression used in the clinic. The underlying mechanism of its therapeutic effect is still unclear. However, recovery of synaptic connections and synaptic remodeling is thought to play a critical role for the clinical efficacy obtained from a rapid antidepressant response. Here, we investigated the relationship between, synaptic changes and concomitant non-neuronal changes in microvasculature and mitochondria, and it relationship to Brain-derived neurotrophic factor (BDNF) level changes after repeated electroconvulsive seizures (ECS), an animal model of ECT...
December 8, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29221780/short-sleep-is-associated-with-more-depressive-symptoms-in-a-multi-ethnic-cohort-of-older-adults
#4
Suzanne Lippman, Hannah Gardener, Tatjana Rundek, Azizi Seixas, Mitchell S V Elkind, Ralph L Sacco, Clinton B Wright, Alberto R Ramos
OBJECTIVES: To evaluate cross-sectional and prospective associations between short and long sleep duration and depressive symptoms in older adults (aged >65 years). METHODS: The data from a subsample of the racially/ethnically diverse Northern Manhattan Study were analyzed. Depressive symptoms were assessed twice with the Center for Epidemiologic Studies Depression Scale (CES-D), approximately 5 years apart. The presence of depressive symptoms was defined as a CES-D score ≥16 or use of antidepressants...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29220371/the-impact-of-different-anti-vascular-endothelial-growth-factor-treatment-regimens-on-reducing-burden-for-caregivers-and-patients-with-wet-age-related-macular-degeneration-in-a-single-center-real-world-japanese-setting
#5
Tsukasa Hanemoto, Yusuke Hikichi, Norimasa Kikuchi, Tadahiko Kozawa
OBJECTIVE: To describe the burden associated with different anti-vascular endothelial growth factor (VEGF) treatment strategies for wet age-related macular degeneration (wAMD) in a real-word setting in Japan. METHODS: Single-center, cross-sectional survey of caregivers of patients with wAMD performed in a hospital in Mito-City, a rural area in Japan. Caregiver burden was evaluated using the Burden Index of Caregivers (BIC-11), and depressive symptoms were assessed by the Center for Epidemiologic Studies Depression scale...
2017: PloS One
https://www.readbyqxmd.com/read/29210983/the-potential-pathogenic-contributions-of-endothelial-barrier-and-arterial-contractile-dysfunction-to-shock-due-to-b-anthracis-lethal-and-edema-toxins
#6
REVIEW
Dante A Suffredini, Xizhong Cui, Wanying Xu, Yan Li, Peter Q Eichacker
Shock with B. anthracis infection is particularly resistant to conventional cardiovascular support and its mortality rate appears higher than with more common bacterial pathogens. As opposed to many bacteria that lack exotoxins directly depressing hemodynamic function, lethal and edema toxin (LT and ET respectively) both cause shock and likely contribute to the high lethality rate with B. anthracis. Selective inhibition of the toxins is protective in infection models, and administration of either toxin alone in animals produces hypotension with accompanying organ injury and lethality...
December 6, 2017: Toxins
https://www.readbyqxmd.com/read/29210283/the-contribution-of-supplementary-tests-in-the-differential-diagnosis-of-dementia
#7
F Moulin de Moraes, P Ferreira Bertolucci
INTRODUCTION: Supplementary tests are part of the clinical approach to diagnose cognitive impairment. We aimed to determine the role of supplementary examinations, except for biomarkers, on diagnostic stability of dementia over time and to identify reversible dementias. METHODS: We identified 432 patients with dementia who performed 2 clinical evaluations and the supplementary examinations recommended by the American Academy of Neurology in a follow-up period of 1 year...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29204738/the-association-between-myocardial-fibrosis-and-depressed-capillary-density-in-rat-model-of-left-ventricular-hypertrophy
#8
Ying Xiao, Yinjie Liu, Jiaming Liu, Y James Kang
Myocardial fibrogenesis is initiated once the coordination between oxygen supply and demand is disrupted in pressure overload-induced cardiac hypertrophy. Clinical observations showed that myocardial fibrosis did not evenly occur in the hypertrophic myocardium. The present study was undertaken to specifically address differential vulnerabilities to fibrogenesis of different regions in the myocardium subjected to pressure overload-induced hypertrophy. SD rats were divided into two groups, sham-operated control and ascending artery constriction-induced cardiac hypotrophy...
December 4, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29203753/-definition-and-treatment-of-stroke-over-the-centuries
#9
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Mariusz Gąsior, Marek Gierlotka
Stroke was already diagnosed in the ancient times. For hundreds of years the treatment of this disease has changed radically. According to the current WHO definition, stroke is a clinical syndrome caused by focal or generalized brain injury that lasts more than 24 hours or leads to death and has no other cause than vascular. Stroke constitutes a big social and economic problem, as it can lead to death or disability. In the highly developed countries stroke is the third most common cause of adult deaths, the second leading cause of dementia, and the most common cause of disability...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29197532/vascular-risk-factor-burden-and-new-onset-depression-in-the-community
#10
Shayna Adams, Sarah Conner, Jayandra J Himali, Alexa Beiser, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase
Depression is associated with an increased likelihood of cardiac events and stroke. We hypothesized that the vascular risk factor burden might itself predispose to both cardiovascular events and depression. Therefore, we examined whether aggregate scores of vascular risk factor burden were associated with the new-onset of depression in the community. We studied 2023 depression- and dementia-free Framingham Heart Study (Framingham, USA) Offspring participants who attended both examination cycles 7 (1998-2001) and 8 (2005-2008)...
November 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29196576/apathy-is-associated-with-incident-dementia-in-community-dwelling-older-people
#11
Jan Willem van Dalen, Lennard L Van Wanrooij, Eric P Moll van Charante, Edo Richard, Willem A van Gool
OBJECTIVE: To assess whether apathy and depressive symptoms are independently associated with incident dementia during 6-year follow-up in a prospective observational population-based cohort study. METHODS: Participants were community-dwelling older people in the Prevention of Dementia by Intensive Vascular Care trial, aged 70-78 years, without dementia at baseline. Apathy and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS-15)...
December 1, 2017: Neurology
https://www.readbyqxmd.com/read/29190502/nacl-changes-stem-morphology-anatomy-and-phloem-structure-in-lucerne-medicago-sativa-cv-gab%C3%A3-s-comparison-of-upper-and-lower-internodes
#12
Riheb Ben Nja, Bruno Merceron, Mireille Faucher, Pierrette Fleurat-Lessard, Emile Béré
In M. sativa cv. Gabès plants treated with 150mM NaCl, the height of the stem is decreased and the internode number, length and diameter are reduced. This depressive effect on growth, but also on photosynthetic activity and water balance, is accompanied by structural changes. In the upper internodes, NaCl treatment increases cambium development, so that the vascular ring is initiated earlier than in controls. In the lower internodes, the number of lignified phloem fibers is increased by NaCl, and their wall thickness is augmented, compared to controls; in the phloem complex, the nacreous layer is enlarged, the number of internal wall ingrowths is increased, but companion cells are damaged...
October 18, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29190292/tnf-%C3%AE-blockade-suppresses-pericystic-inflammation-following-anthelmintic-treatment-in-porcine-neurocysticercosis
#13
Siddhartha Mahanty, Miguel A Orrego, Carla Cangalaya, M Paz Adrianzen, Gianfranco Arroyo, Juan Calcina, Armando E Gonzalez, Héctor H García, Cristina Guerra-Giraldez, Theodore E Nash
BACKGROUND: Neurocysticercosis (NCC) is an infection of the brain with the larval cyst of the tapeworm, Taenia solium. Cysticidal treatment induces parasite killing resulting in a post inflammatory response and seizures, which generally requires corticosteroid treatment to control inflammation. The nature of this response and how to best control it is unclear. We investigated the anti-inflammatory effects of pretreatment with etanercept (ETN), an anti-tumor necrosis factor agent, or dexamethasone (DEX), a high potency corticosteroid, on the post treatment inflammatory response in naturally infected pigs with neurocysticercosis after a single dose of the cysticidal drug praziquantel (PZQ)...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29190102/integrative-proteomics-metabolomics-strategy-for-pathological-mechanism-of-vascular-depression-mouse-model
#14
Hongxia Zhao, Hongli Du, Min Liu, Songyan Gao, Na Li, Yufan Chao, Ruiqing Li, Wei Chen, Ziyang Lou, Xin Dong
Vascular depression (VD), a subtype of depression, is caused by vascular diseases or cerebrovascular risk factors. Recently, the proportion of VD patients has increased significantly, which severely affects their quality of life. However, the current pathogenesis of VD has not yet been fully understood, and the basic research is not adequate. In this study, on the basis of the combination of LC-MS-based proteomics and metabolomics, we aimed to establish a protein metabolism regulatory network in a murine VD model to elucidate a more comprehensive impact of VD on organisms...
December 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29180214/thioredoxin-1-attenuates-sepsis-induced-cardiomyopathy-after-cecal-ligation-and-puncture-in-mice
#15
Rickesha L Wilson, Vaithinathan Selvaraju, Rajesh Lakshmanan, Mahesh Thirunavukkarasu, Jacob Campbell, David W McFadden, Nilanjana Maulik
BACKGROUND: Sepsis is a leading cause of mortality among patients in intensive care units across the USA. Thioredoxin-1 (Trx-1) is an essential 12 kDa cytosolic protein that, apart from maintaining the cellular redox state, possesses multifunctional properties. In this study, we explored the possibility of controlling adverse myocardial depression by overexpression of Trx-1 in a mouse model of severe sepsis. METHODS: Adult C57BL/6J and Trx-1Tg/+ mice were divided into wild-type sham (WTS), wild-type cecal ligation and puncture (WTCLP), Trx-1Tg/+sham (Trx-1Tg/+S), and Trx-1Tg/+CLP groups...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29169581/vitamin-d-status-is-associated-with-executive-function-a-decade-later-data-from-the-women-s-healthy-ageing-project
#16
Alicia M Goodwill, Stephen Campbell, Steven Simpson, Maria Bisignano, Cherie Chiang, Lorraine Dennerstein, Cassandra Szoeke
OBJECTIVES: Vitamin D deficiency has been associated with cognitive decline and dementia in older adults. However, there is a paucity of studies assessing whether this association manifests from midlife. Given the long prodromal stage of dementia, we investigated the association between midlife vitamin D and cognition 10 years later. STUDY DESIGN: 252 participants (aged 55-67 years) from the Women's Healthy Ageing Project had baseline (2002) vitamin D and neuropsychological measures assessed...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29156413/anterior-posterior-gradient-differences-in-lobar-and-cingulate-cortex-cerebral-blood-flow-in-late-life-depression
#17
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
Vascular pathology is common in late-life depression, contributing to changes in cerebral function. We examined whether late-life depression was associated with differences in cerebral blood flow (CBF) and whether such differences were related to vascular risk and cerebrovascular pathology, specifically white matter hyperintensity (WMH) volumes. Twenty-three depressed elders and 20 age- and sex-matched elders with no psychiatric history completed cranial 3T MRI. MRI procedures included a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition obtained while on room air and during a hypercapnia challenge allowing for calculation of cerebrovascular reactivity (CVR)...
November 11, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29146648/economic-evaluation-of-an-e-mental-health-intervention-for-patients-with-retinal-exudative-diseases-who-receive-intraocular-anti-vegf-injections-e-pseye-protocol-for-a-randomised-controlled-trial
#18
Hilde P A van der Aa, Ger H M B van Rens, Frank D Verbraak, Machteld Bosscha, Marc A Koopmanschap, Hannie C Comijs, Pim Cuijpers, Ruth M A van Nispen
INTRODUCTION: Because of the great potential of vascular endothelial growth factor inhibitors (anti-VEGF) for retinal exudative diseases, an increased number of patients receives this treatment. However, during this treatment, patients are subjected to frequent invasive intravitreal injections, and the effects on reversing the process of vision loss are uncertain, which may have negative consequences for patients' mental health. One in three patients experience at least mild symptoms of depression/anxiety...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146553/impact-of-marital-status-on-outcomes-following-st-segment-elevation-myocardial-infarction
#19
Moo Hyun Kim, Kwang Min Lee, Soo Jin Kim, So Yeon Kim, Jong Seong Park, Young Rak Cho, Kyungil Park, Tae Ho Park, Young Dae Kim, Victor Serebruany
BACKGROUND: Mood disorders, depression, and loneliness are established risk factors for thrombotic occlusions. Social relationships in general, and marital status in particular may play a role in predicting cardiovascular outcomes and survival after ST-segment elevation myocardial infarction (STEMI), but the evidence is inconclusive especially in Asians. METHODS: The Korean patients presented with STEMI (n=980) constituted married (n=780); or widowed, divorced, or single (WDS, n=200) groups...
July 22, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29145183/catastrophe-reaction-and-emotionalism
#20
Antonio Carota, Julien Bogousslavsky
The catastrophic reaction (CR; a disruptive and uncontrolled behavior triggered by anger, irritability, and hostility) and emotionalism (a condition of uncontrolled crying or laughing) are disorders of the emotional regulation and expression, the prevalence of which is underestimated in neurology. Their occurrence is an additional factor of poor outcome for neurologic patients. Although they have been recognized and completely described in their clinical manifestations more than a century ago, many issues remain unsolved regarding their pathogenesis and the respective role of the brain damage and psychological factors...
2018: Frontiers of Neurology and Neuroscience
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