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https://www.readbyqxmd.com/read/29037887/depression-and-related-risk-factors-among-patients-with-type-2-diabetes-mellitus-jazan-area-ksa-a-cross-sectional-study
#1
Osama B Albasheer, Mohammed S Mahfouz, Yahia Solan, Duaa A Khan, Mohammed A Muqri, Haneen A Almutairi, Ali M Alelyani, Hussain A Alahmed
PURPOSE: To determine the prevalence of depression and related risk factors among type 2 diabetes mellitus patients (T2DM) in Jazan area, Saudi Arabia. METHOD: A cross sectional, self-administered questionnaire study was conducted among T2DM patients in Jazan area, Saudi Arabia. A total of 385 patients were selected at randomly. The Patient Health Questionnaire (PHQ-9) was utilized to measure symptoms and signs of depression. RESULTS: The overall prevalence of depression among T2DM patients was 37...
September 28, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29035088/the-last-25-years-of-obstructive-sleep-apnea-epidemiology-and-the-next-25
#2
Paul E Peppard, Erika W Hagen
Considerable new knowledge regarding the epidemiology of obstructive sleep apnea (OSA) in adults arose from large-scale population-based epidemiologic investigations that initiated in the late 1980s to 1990s; these investigations have continued to produce relevant findings in recent years. In this Perspective, we briefly comment on the past 25 years of adult population-based OSA epidemiology and discuss selected ways in which the field can further progress over the coming decades. Population-based studies have shown that OSA is common in both men and women, and that prevalence is increasing...
October 16, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29034347/using-a-weaning-immunosuppression-protocol-in-liver-transplantation-recipients-with-hepatocellular-carcinoma-a-compromise-between-the-risk-of-recurrence-and-the-risk-of-rejection
#3
REVIEW
Roberta Angelico, Alessandro Parente, Tommaso Maria Manzia
Hepatocellular carcinoma (HCC) recurrence rate after liver transplantation (LT) is still up to 15-20%, despite a careful selection of candidates and optimization of the management within the waiting list. To reduce tumour recurrence, the currently adopted post-transplant strategies are based on the administration of a tailored immunosuppression (IS) regimen. Drug-induced depression of the immune system is essential in preventing graft rejection, however has a well-established association with oncogenesis. The immune system has a key role as a defending mechanism against cancer development, preventing vascular invasion and metastasis...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29026673/endoscopic-management-of-a-cavernous-malformation-on-the-floor-of-third-ventricle-and-aqueduct-of-sylvius-technical-case-report-and-review-of-the-literature
#4
Luis Alberto Ortega-Porcayo, Alexander Perdomo-Pantoja, Isaac Jair Palacios-Ortíz, Salomon Cohen Cohen, Juan Pablo González-Mosqueda, Juan Luis Gómez-Amador
BACKGROUND: Intraventricular cavernous malformations are unusual intracranial vascular malformations; their deep anatomical location complicates their surgical management. Microsurgical approaches are the gold standard approaches for the resection of ventricular lesions, however, they imply considerable neurovascular risks. CASE DESCRIPTION: A 51-year-old patient presented with acute headache, diplopia, vertigo, blurred vision, and a depressed level of consciousness...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29023080/depression-is-linked-to-dementia-in-older-adults
#5
COMMENT
Vyara Valkanova, Klaus P Ebmeier, Charlotte L Allan
Depression and dementia are both common conditions in older people, and they frequently occur together. Late life depression affects about 3.0-4.5% of adults aged 65 and older. Depression occurs in up to 20% of patients with Alzheimer’s disease and up to 45% of patients with vascular dementia. Rather than a risk factor, depression with onset in later life is more likely to be either prodromal to dementia or a condition that unmasks pre-existing cognitive impairment by compromising cognitive reserve. Depression can be a psychological response to receiving a diagnosis of dementia...
January 2017: Practitioner
https://www.readbyqxmd.com/read/28992663/metabolic-analysis-of-the-anti-depressive-effects-of-yangxinshi-tablet-in-a-vascular-depression-model-in-mice
#6
Hongli Du, Hai Zhang, Yahong Zhao, Min Liu, Anni Chen, Shiyu Liu, Dan Xue, Yanjun Liu, Guoqing Zhang
In recent years, vascular depression has become the focus of international attention. Yangxinshi Tablet (YXST) is usually used in clinic for treatment of arrhythmia and heart failure, but we found that it also has anti-depressive effect in this study. The objective of the study was to identify biomarkers related to vascular depression in hippocampus and explore the anti-depressive effects of YXST on the mice model. Untargeted metabolomics based on UHPLC-Q-TOF/MS was applied to identify significant differential biomarkers between model group and control group...
October 9, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28991824/the-%C3%AE-blocker-esmolol-restores-the-vascular-waterfall-phenomenon-after-acute-endotoxemia
#7
Wei Du, Dawei Liu, Yun Long, Xiaoting Wang
BACKGROUND: A vascular waterfall occurs when the critical closing pressure is greater than the mean systemic filling pressure. Because the waterfall phenomenon likely exists in the microcirculation, β1-receptor blockers such as esmolol could have some effect on microcirculation and vascular waterfall. OBJECTIVES: To determine whether a vascular waterfall exists during septic shock and to assess the effects of vasopressors and β-blockers on vascular waterfall. DESIGN: Sixteen mongrel dogs were mounted with ultrasonic flow probes to measure renal blood flow...
October 6, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28989805/migraine-and-stroke
#8
REVIEW
Yonghua Zhang, Aasheeta Parikh, Shuo Qian
Migraines are generally considered a relatively benign neurological condition. However, research has shown an association between migraines and stroke, and especially between migraine with aura and ischaemic stroke. Patients can also suffer from migrainous infarction, a subset of ischaemic stroke that often occurs in the posterior circulation of younger women. The exact pathogenesis of migrainous infarct is not known, but it is theorised that the duration and local neuronal energy level from cortical spreading depression may be a key factor...
September 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28984595/low-prevalence-and-clinical-effect-of-vascular-risk-factors-in-early-onset-alzheimer-s-disease
#9
Yaohua Chen, Adeline Rollin Sillaire, Jean Dallongeville, Emilie Skrobala, David Wallon, Bruno Dubois, Didier Hannequin, Florence Pasquierthe
BACKGROUND: Determinants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28978136/nanofat-derived-stem-cells-with-platelet-rich-fibrin-improve-facial-contour-remodeling-and-skin-rejuvenation-after-autologous-structural-fat-transplantation
#10
Hua Wei, Shi-Xing Gu, Yi-Dan Liang, Zhi-Jie Liang, Hai Chen, Mao-Guang Zhu, Fang-Tian Xu, Ning He, Xiao-Juan Wei, Hong-Mian Li
Traditional autologous fat transplantation is a common surgical procedure for treating facial soft tissue depression and skin aging. However, the transplanted fat is easily absorbed, reducing the long-term efficacy of the procedure. Here, we examined the efficacy of nanofat-assisted autologous fat structural transplantation. Nanofat-derived stem cells (NFSCs) were isolated, mechanically emulsified, cultured, and characterized. Platelet-rich fibrin (PRF) enhanced proliferation and adipogenic differentiation of NFSCs in vitro...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28976215/mania-following-antidepressant-discontinuation-in-depression-two-case-reports
#11
Cecilia Sze Nga Kwok, Leslie Eng Choon Lim
OBJECTIVE: Antidepressant-induced mania and an antidepressant discontinuation syndrome are well documented, whereas mania occurring after antidepressant cessation has been infrequently reported. METHOD: We describe antidepressant discontinuation-related mania in two Chinese patients, as well as a review of the literature on this phenomenon in unipolar depression. RESULTS: A 72-year-old man and a 65-year-old woman had late-onset depression with vascular risk factors, but no personal or family history of mood disorders...
September 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28974274/subjective-cognitive-decline-modifies-the-relationship-between-cerebral-blood-flow-and-memory-function-in-cognitively-normal-older-adults
#12
Chelsea C Hays, Zvinka Z Zlatar, Laura Campbell, M J Meloy, Christina E Wierenga
OBJECTIVES: Subjective cognitive decline (SCD), or self-reported cognitive decline despite normal neuropsychological test performance, is a risk factor for objective cognitive decline and Alzheimer's disease (AD). While brain mechanisms contributing to SCD are not well defined, studies show associations with vascular risk factors and altered cerebral blood flow (CBF), raising the hypothesis that those with SCD might be experiencing vascular dysregulation, or a disruption in the normal relationship between CBF and cognition...
October 4, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28970278/histopathological-abnormalities-in-the-central-arteries-and-veins-of-fontan-subjects
#13
Brandon S Hays, Michael Baker, Annie Laib, Wei Tan, Sebastian Udholm, Bryan H Goldstein, Stephen P Sanders, Alexander R Opotowsky, Gruschen R Veldtman
OBJECTIVE: Fontan circulations have obligatory venous hypertension, depressed cardiac output and abnormal arterial elastance. Ventriculovascular coupling is known to be abnormal, but the underlying mechanisms are poorly defined. We aim to describe the histopathological features of vascular remodelling encountered in the central arteries and veins in the Fontan circulation as a possible underlying pathological representation of abnormal ventriculovascular coupling. METHODS: Postmortem vasculature (inferior vena cava (IVC), superior vena cava (SVC), pulmonary artery (PA), pulmonary vein (PV) and aorta) of 13 patients with a Fontan circulation (mean age 29...
September 29, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28968957/a-risk-prediction-model-for-post-stroke-depression-in-chinese-stroke-survivors-based-on-clinical-and-socio-psychological-features
#14
Rui Liu, Yingying Yue, Haitang Jiang, Jian Lu, Aiqin Wu, Deqin Geng, Jun Wang, Jianxin Lu, Shenghua Li, Hua Tang, Xuesong Lu, Kezhong Zhang, Tian Liu, Yonggui Yuan, Qiao Wang
BACKGROUND: Post-stroke depression (PSD) is a frequent complication that worsens rehabilitation outcomes and patient quality of life. This study developed a risk prediction model for PSD based on patient clinical and socio-psychology features for the early detection of high risk PSD patients. RESULTS: Risk predictors included a history of brain cerebral infarction (odds ratio [OR], 3.84; 95% confidence interval [CI], 2.22-6.70; P < 0.0001) and four socio-psychological factors including Eysenck Personality Questionnaire with Neuroticism/Stability (OR, 1...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967365/hypermobility-the-ehlers-danlos-syndromes-and-chronic-pain
#15
REVIEW
Delfien Syx, Inge De Wandele, Lies Rombaut, Fransiska Malfait
Chronic widespread pain is a common complaint among individuals affected by generalised joint hypermobility. In the absence of other conditions that cause chronic pain, these individuals are usually diagnosed with joint hypermobility syndrome (JHS). JHS is a multifactorial trait with a strong genetic basis, but no specific genetic markers. Clinical overlap of JHS is seen with heritable connective tissue disorders, particularly with the Ehlers-Danlos syndrome, hypermobile type (hEDS). The Ehlers-Danlos syndromes (EDS) comprise a heterogeneous group of rare monogenic conditions that are characterised by joint hypermobility, skin and vascular fragility and generalised connective tissue friability, and are caused by genetic defects in an array of extracellular matrix genes...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28958051/psychosocial-pathways-to-racial-ethnic-inequalities-in-late-life-memory-trajectories
#16
Laura B Zahodne, Ketlyne Sol, Zarina Kraal
Objectives: Blacks and Hispanics are at increased risk for dementia, even after socioeconomic and vascular factors are taken into account. This study tests a comprehensive model of psychosocial pathways leading to differences in longitudinal cognitive outcomes among older blacks and Hispanics, compared to non-Hispanic whites. Methods: Using data from 10,173 participants aged 65 and older in the Health and Retirement Study, structural equation models tested associations among race/ethnicity, perceived discrimination, depressive symptoms, external locus of control, and 6-year memory trajectories, controlling for age, sex, educational attainment, income, wealth, and chronic diseases...
September 6, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28957372/social-network-composition-of-vascular-patients-and-its-associations-with-health-behavior-and-clinical-risk-factors
#17
Naomi Heijmans, Jan van Lieshout, Michel Wensing
BACKGROUND: This study aimed to explore linkages of patients' social network composition with health behaviors and clinical risk factors. METHODS/DESIGN: This observational study was embedded in a project aimed at improving cardiovascular risk management (CRVM) in primary care. 657 vascular patients (227 with cardiovascular disease, 380 at high vascular risk), mean age 72.4 (SD 9.4) years, were recruited as were individuals patients considered important for dealing with their disease, so called alters (n = 487)...
2017: PloS One
https://www.readbyqxmd.com/read/28954594/subjective-memory-change-mood-and-cerebrovascular-risk-factors-in-older-african-americans
#18
Scott A Sperling, Siny Tsang, Ishan C Williams, Moon Ho Park, Ira M Helenius, Carol A Manning
OBJECTIVE: Subjective memory change (SMC) in older individuals may represent a harbinger of cognitive decline. This study examined the factors associated with SMC in older African Americans (AA), who have greater risk of developing dementia. We predicted that symptoms of depression and anxiety, as well as the total number of cerebrovascular risk factors (tCVRFs), but not performances on objective memory measures, would be positively associated with SMC. METHODS: Ninety-six AA completed brief cognitive testing and answered questions about mood and memory at their primary care appointment...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28944745/obesity-a-possible-risk-factor-for-restless-legs-syndrome
#19
Demet Yildiz, Nilufer Buyukkoyuncu, Ahmet Kasim Kilic, Soner Cander, Abdülmecit Yıldız, Aygul Gunes, Meral Seferoglu, Sevda Erer Ozbek
AIM/BACKGROUND: Restless legs syndrome (RLS) is a frequent neurological and sleep disorder. Metabolic disorders are known to be related to sleep disorders. We prospectively evaluated whether obesity and its possible cofactors were related to the presence of RLS. MATERIALS AND METHODS: The study included 143 obese and 94 non-obese individuals. Obese patients had a BMI of 30 and over, while non-obese patients had a BMI lower than 30. Patients with arthritis and pregnancy were excluded but not those with diabetes mellitus...
September 25, 2017: Neurological Research
https://www.readbyqxmd.com/read/28936936/-treatment-of-dementia
#20
K Blom, G A H van den Elsen, H L Koek, J B Sanders, H C Kruithof, J A H R Claassen
- Treatment options for patients with dementia are limited. This article provides an overview of possible interventions, both pharmaceutical and non-pharmaceutical, for Alzheimer's disease, vascular dementia and mixed dementia.- Pharmaceutical treatment options include cholinesterase inhibitors, memantine and experimental medication. Cholinesterase inhibitors are only recommended for Alzheimer's disease and mixed dementia, not for vascular dementia or mild cognitive impairment. There is no proof of effectiveness for the other pharmaceutical options...
2017: Nederlands Tijdschrift Voor Geneeskunde
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