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non-coding RNA AND nasopharyngeal

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https://www.readbyqxmd.com/read/29138808/the-biology-and-function-of-extracellular-vesicles-in-nasopharyngeal-carcinoma-review
#1
Bo You, Ying Shan, Lili Bao, Jing Chen, Liu Yang, Qicheng Zhang, Wei Zhang, Zhenxin Zhang, Jie Zhang, Si Shi, Yiwen You
Extracellular vesicles are a heterogeneous group of membrane-enclosed vesicles, which play an important role in intercellular communication. Increasing number of studies have shown that tumor-derived extracellular vesicles might be involved in the transfer of oncogenic cargo (proteins, lipids, messenger RNA, microRNA, non-coding RNAs and DNA) through which cancer cells could shape the tumor microenvironment and influence tumor progression. Nasopharyngeal carcinoma-derived extracellular vesicles have also reported to facilitate tumor proliferation, metastasis and immune escape...
November 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29057544/afap1-as1-a-novel-oncogenic-long-non-coding-rna-in-human-cancers
#2
REVIEW
Fuyou Zhang, Jianfa Li, Huizhong Xiao, Yifan Zou, Yuchen Liu, Weiren Huang
Long non-coding RNAs (lncRNAs), a group of non-protein-coding RNAs with more than 200 nucleotides in length, are involved in multiple biological processes, such as the proliferation, apoptosis, migration and invasion. Moreover, numerous studies have shown that lncRNAs play important roles as oncogenes or tumour suppressor genes in human cancers. In this paper, we concentrate on actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a well-known long non-coding RNA that is overexpressed in various tumour tissues and cell lines, including oesophageal cancer, pancreatic ductal adenocarcinoma, nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, ovarian cancer, colorectal cancer, biliary tract cancer and gastric cancer...
October 22, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29050268/long-non-coding-rna-neat1-regulates-epithelial-membrane-protein-2-expression-to-repress-nasopharyngeal-carcinoma-migration-and-irradiation-resistance-through-mir-101-3p-as-a-competing-endogenous-rna-mechanism
#3
Yujia Wang, Chunting Wang, Can Chen, Fengbo Wu, Pengfei Shen, Peng Zhang, Gu He, Xiang Li
The altered expression of long non-coding RNAs (lncRNAs) is often related to carcinogenesis, metastasis and resistance to radiation or chemotherapy. In the current study, cDNA microarray analysis found that NEAT1 expression was reduced in nasopharyngeal carcinoma (NPC) patients and that it regulated NPC progression. However, the detailed mechanisms of NEAT1 in NPC were unclear. NEAT1 repressed NPC cell growth, invasion and radiation resistance in vitro and tumor metastasis in vivo. In addition, the results of an approach integrating bioinformatics, luciferase reporter assays and RNA immunoprecipitation indicated that NEAT1 antagonized miR-101-3p through a competing endogenous RNA (ceRNA) mechanism and that the interaction between NEAT1 and EMP2 was miR-101-3p dependent...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977945/genetic-polymorphisms-of-long-non-coding-rna-gas5-predict-platinum-based-concurrent-chemoradiotherapy-response-in-nasopharyngeal-carcinoma-patients
#4
Zhen Guo, Youhong Wang, Yu Zhao, Yi Jin, Liang An, Bin Wu, Zhaoqian Liu, Xiaoping Chen, Honghao Zhou, Hui Wang, Wei Zhang
LncRNA GAS5 plays a tumor suppressive role in a variety of human cancers and promises to be a novel diagnostic biomarker, therapy target, as well as prognostic biomarker. However, the role of GAS5 in nasopharyngeal carcinoma (NPC) remains elusive. The objective of the present study was to evaluate the effect of single nucleotide polymorphisms (SNPs) in GAS5 on treatment efficacy and toxicity in NPC patients receiving chemoradiotherapy. Three potentially functional SNPs of GAS5 were genotyped in 267 NPC patients and validated in another 238 NPC patients treated with chemoradiotherapy from southern China...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28951465/super-enhancers-promote-transcriptional-dysregulation-in-nasopharyngeal-carcinoma
#5
Jiang Yuan, Yan-Yi Jiang, Anand Mayakonda, Moli Huang, Ling-Wen Ding, Han Lin, Fenggang Yu, Yanan Lu, Thomas Kwok Seng Loh, Marilynn Chow, Samantha L Savage, Jeffrey W Tyner, De-Chen Lin, H Phillip Koeffler
Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southeast Asia and Southern China. The pathogenic mechanisms of NPC, particularly those involving epigenetic dysregulation, remain largely elusive, hampering clinical management of this malignancy. To identify novel druggable targets, we carried out an unbiased high-throughput chemical screening and observed that NPC cells were highly sensitive to inhibitors of cyclin-dependent kinases (CDK), especially THZ1, a covalent inhibitor of CDK7...
September 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28857668/malat1-mir-124-capn4-axis-regulates-proliferation-invasion-and-emt-in-nasopharyngeal-carcinoma-cells
#6
Baoyuan Shi, Yandan Wang, Fengfang Yin
BACKGROUND: Long non-coding RNA MALAT1 (Metastasis-associated lung Adenocarcinoma transcript-1) has been demonstrated to play a critical role in the regulation of cancer progression and metastasis. However, little is known about MALAT1 in nasopharyngeal carcinoma (NPC) pathogenesis and progression. METHODS: Quantitative real-time PCR (qRT-PCR) was conducted to measure the expression of MALAT1, miR-124 and Capn4 mRNA in NPC cell lines. The protein level of Capn4 was examined by western blot analysis...
October 3, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28810605/microrna-19a-promotes-nasopharyngeal-carcinoma-by-targeting-transforming-growth-factor-%C3%AE-receptor-2
#7
Fang Ma, Zhiyuan Wang, Jingjing Wang, Xianling Liu, Chunhong Hu
MicroRNA (miR), a class of small non-coding RNA, function as key regulators in gene expression through directly binding to the 3' untranslated region of their target mRNA, which further leads to translational repression or mRNA degradation. miR-19a, a member of miR-17-92 cluster, has an oncogenic role in a variety of malignant tumors. However, the exact role of miR-19a in nasopharyngeal carcinoma (NPC) has not previously been studied. The present study aimed to investigate the function and mechanism of miR-19a in regulating the viability and invasion of NPC cells...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28728844/long-non-coding-rna-pcat7-regulates-elf2-signaling-through-inhibition-of-mir-134-5p-in-nasopharyngeal-carcinoma
#8
Yejun Liu, Zezhang Tao, Jining Qu, Xuhong Zhou, Chenghong Zhang
While some long noncoding RNAs (lncRNAs) might promote nasopharyngeal carcinoma (NPC) initiation and progression, the involved molecular mechanisms remain largely unclear. Here, we discovered the novel LncRNA, prostate cancer associated transcript 7 (PCAT7), which was overexpressed and associated with worse prognosis in NPC. Decreased PCAT7 expression was found to significantly suppress tumor cell proliferation in vitro, and inhibited tumor growth and reduced the expression of proliferation antigen Ki-67 in vivo...
September 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28670387/down-regulation-of-long-non-coding-rna-afap1-as1-inhibits-tumor-cell-growth-and-invasion-in-lung-adenocarcinoma
#9
Yi Zhuang, Hanyi Jiang, Hui Li, Jinhong Dai, Yin Liu, Yan Li, Liyun Miao, Hourong Cai, Yonglong Xiao, Hongping Xia, Yongsheng Wang, Mingke Shi
An increasing number of deregulated long non-coding RNAs (lncRNA) have been implicated in cancer in humans, suggesting that lncRNAs may be involved in tumorigenesis or tumor progression. In previous investigations, lncRNA, AFAP1-AS1 has been found to be associated with several cancers, including nasopharyngeal carcinoma, lung cancer and esophageal adenocarcinoma. However, the function of AFAP1-AS1 in lung cancer has not been reported. In our present study, we found that AFAP1-AS1 was overexpressed in lung adenocarcinoma and associated with survival time...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28402230/downregulation-of-lncrna-anril-inhibits-proliferation-induces-apoptosis-and-enhances-radiosensitivity-in-nasopharyngeal-carcinoma-cells-through-regulating-mir-125a
#10
Xigang Hu, Huijuan Jiang, Xiaojun Jiang
Increasing evidence demonstrated that long non-coding RNA ANRIL serves as a fatal oncogene in many cancers, including nasopharyngeal carcinoma (NPC). However, little is known whether ANRIL regulated NPC cell radioresistance. Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA ANRIL and miR-125a in NPC tissues and cell lines. MTT assay was conducted to measure the cell viability of CNE2 and HONE1 cells. The apoptotic rate of CNE2 and HONE1 cells was determined by flow cytometry analysis...
May 4, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28380458/co-expression-of-afap1-as1-and-pd-1-predicts-poor-prognosis-in-nasopharyngeal-carcinoma
#11
Yanyan Tang, Yi He, Lei Shi, Liting Yang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Can Guo, Shanshan Zhang, Zhaojian Gong, Xiayu Li, Fang Xiong, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Nasopharyngeal carcinoma (NPC) carries a high potential for metastasis and immune escape, with a great risk of relapse after primary treatment. Through analysis of whole genome expression profiling data in NPC samples, we found that the expression of a long non-coding RNA (lncRNA), actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), is significantly correlated with the immune escape marker programmed death 1 (PD-1). We therefore assessed the expression of AFAP1-AS1 and PD-1 in a cohort of 96 paraffin-embedded NPC samples and confirmed that AFAP1-AS1 and PD-1 are co-expressed in infiltrating lymphocytes in NPC tissue...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28358263/lncrna-ccat1-modulates-the-sensitivity-of-paclitaxel-in-nasopharynx-cancers-cells-via-mir-181a-cpeb2-axis
#12
Qiaosu Wang, Wenjing Zhang, Shaojuan Hao
Recent studies reported that long non-coding RNA (lncRNA) might play critical roles in regulating chemo-resistant of multiple types of cancer. This study aimed to investigate whether long non-coding RNA CCAT1 was involved in Paclitaxel resistance in nasopharyngeal carcinoma (NPC). qRT-PCR was used for testing the expression of CCAT1, miR-181a and CPEB2 in tumor tissues and NPC cancers. NPC cells were transfected with siRNAs to suppress the mRNA level of CCAT1 in NPC cells. MTT assays and flow cytometry analysis were used to assess the sensitivity of paclitaxel in NPC cells...
April 18, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28328537/long-non-coding-rna-loc100129148-functions-as-an-oncogene-in-human-nasopharyngeal-carcinoma-by-targeting-mir-539-5p
#13
Kai-Yu Sun, Tao Peng, Zhe Chen, Peng Song, Xu-Hong Zhou
Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including human nasopharyngeal carcinoma (NPC). The correlation between lncRNAs expression and NPC development has not been well identified in the recent literature. Recently, high-through put analysis reveals that LOC100129148 is highly expressed in NPC. However, whether the aberrant expression of LOC100129148 in NPC is corrected with tumorigenesis or prognosis has not been investigated. Herein, we identified that LOC100129148 was up-regulated in NPC tissues and cell lines, and higher expression of LOC100129148 resulted in a markedly poorer survival time...
March 21, 2017: Aging
https://www.readbyqxmd.com/read/28245169/long-non-coding-rna-linc0086-functions-as-a-tumor-suppressor-in-nasopharyngeal-carcinoma-by-targeting-mir-214
#14
Jie Guo, Jinqi Ma, Guosheng Zhao, Guocai Li, Yunfeng Fu, Yanwei Luo
Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, occurring at high frequency in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression, including NPC. Here, we established a comprehensive lncRNA profiles in NPC and found that 35 lncRNAs were differentially expressed in NPC. We found that LINC0086 decreased in NPC patient serum samples and tissues. The Kaplan-Meier survival cure showed that the patients with high LINC0086 expression had higher survival rate than those with low LINC0086 expression...
February 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28117929/downregulation-of-lncrna-anril-represses-tumorigenicity-and-enhances-cisplatin-induced-cytotoxicity-via-regulating-microrna-let-7a-in-nasopharyngeal-carcinoma
#15
Yandan Wang, Nan Cheng, Junpeng Luo
Many studies have demonstrated that upregulation of long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) plays an oncogenic role in various tumors, including nasopharyngeal carcinoma (NPC). The aim of this study is to explore the effect of ANRIL in NPC progression and cisplatin (DDP)-induced cytotoxicity. The results showed that ANRIL was highly expressed and let-7a was downregulated in NPC tissues and cells. Luciferase assay revealed that ANRIL could negatively regulate miR-let-7a expression...
January 24, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27855392/the-emerging-roles-of-long-noncoding-rna-ror-lincrna-ror-and-its-possible-mechanisms-in-human-cancers
#16
REVIEW
Yan Pan, Chen Li, Jing Chen, Kai Zhang, Xiaoyuan Chu, Rui Wang, Longbang Chen
To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing technology, lncRNAs have gained extended attentions nowadays and are found to play important roles in tumorigenesis and progression of human cancers...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27816050/long-non-coding-rna-ewsat1-promotes-human-nasopharyngeal-carcinoma-cell-growth-in-vitro-by-targeting-mir-326-330-5p
#17
Peng Song, Shu-Cheng Yin
Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). However, whether the aberrant expression of EWSAT1 in NPC is corrected with malignancy or prognosis has not been expounded. Herein, we identified that EWSAT1 was up-regulated in NPC tissues and cell lines, and higher expression of EWSAT1 resulted in a markedly poorer survival time...
November 3, 2016: Aging
https://www.readbyqxmd.com/read/27597634/downregulation-of-long-non-coding-rna-meg3-in-nasopharyngeal-carcinoma
#18
Wing-Po Chak, Raymond Wai-Ming Lung, Joanna Hung-Man Tong, Sylvia Yat-Yee Chan, Samantha Wei-Man Lun, Sai-Wah Tsao, Kwok-Wai Lo, Ka-Fai To
In our previous whole-transcriptome sequencing analysis, downregulation of a long non-coding RNA, maternally expressed gene 3 (MEG3), was identified in NPC samples. This finding suggests the possible role of MEG3 as a tumor suppressor in this distinctive disease. In the present study, two MEG3 variants, AF119863 (MEG3-AF) and BX247998 (MEG3-BX), were found abundantly expressed in a normal nasopharyngeal epithelial cell line, NP69. Significant downregulation of MEG3-AF was further verified in a panel of NPC samples including xenografts and primary biopsies...
March 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27584792/epstein-barr-virus-encoded-mir-bart6-3p-inhibits-cancer-cell-metastasis-and-invasion-by-targeting-long-non-coding-rna-loc553103
#19
Baoyu He, Weiming Li, Yingfen Wu, Fang Wei, Zhaojian Gong, Hao Bo, Yumin Wang, Xiayu Li, Bo Xiang, Can Guo, Qianjin Liao, Pan Chen, Xuyu Zu, Ming Zhou, Jian Ma, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Epstein-Barr virus (EBV) infection is causatively related to a variety of human cancers, including nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 mature miRNAs, a number of which have been proven to promote carcinogenesis by targeting host genes or self-viral genes. However, in this study, we found that an EBV-encoded microRNA, termed EBV-miR-BART6-3p, inhibited EBV-associated cancer cell migration and invasion including NPC and GC by reversing the epithelial-mesenchymal transition (EMT) process...
September 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27584791/rbm24-suppresses-cancer-progression-by-upregulating-mir-25-to-target-malat1-in-nasopharyngeal-carcinoma
#20
Wen-Feng Hua, Qian Zhong, Tian-Liang Xia, Qi Chen, Mei-Yin Zhang, Ai-Jun Zhou, Zi-Wei Tu, Chen Qu, Man-Zhi Li, Yun-Fei Xia, Hui-Yun Wang, Dan Xie, Francois-Xavier Claret, Er-Wei Song, Mu-Sheng Zeng
Abnormal interaction between non-coding RNAs has been demonstrated to be a common molecular event in various human cancers, but its significance and underlying mechanisms have not been well documented. RNA-binding proteins (RBPs) are key regulators of RNA transcription and post-transcriptional processing. In this study, we found that RNA-binding protein 24 (RBM24) was frequently downregulated in nasopharyngeal carcinoma (NPC). The restoration of RBM24 expression suppressed NPC cellular proliferation, migration and invasion and impeded metastatic colonization in mouse models...
September 1, 2016: Cell Death & Disease
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