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neurovascular reactivity

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https://www.readbyqxmd.com/read/28152241/invalidation-of-fmri-experiments-secondary-to-neurovascular-uncoupling-in-patients-with-cerebrovascular-disease
#1
Andrea E Para, Kevin Sam, Julien Poublanc, Joseph A Fisher, Adrian P Crawley, David J Mikulis
PURPOSE: Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is a technique used to infer neuronal activity from the observed changes in blood flow. Cerebrovascular reactivity (CVR) is the ability of arterioles to increase blood flow in response to vasodilatory stimulus. We hypothesize that in areas of disease where there is exhausted vascular reserve and impaired CVR there will be diminished blood flow response following neuronal activation, and that these areas would appear as false-negative tests on BOLD fMRI...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28112024/inversion-of-neurovascular-coupling-after-subarachnoid-hemorrhage-in%C3%A2-vivo
#2
Matilde Balbi, Masayo Koide, George C Wellman, Nikolaus Plesnila
Subarachnoid hemorrhage (SAH) induces acute changes in the cerebral microcirculation. Recent findings ex vivo suggest neurovascular coupling (NVC), the process that increases cerebral blood flow upon neuronal activity, is also impaired after SAH. The aim of the current study was to investigate whether this occurs also in vivo. C57BL/6 mice were subjected to either sham surgery or SAH by filament perforation. Twenty-four hours later NVC was tested by forepaw stimulation and CO2 reactivity by inhalation of 10% CO2...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28057519/col4a1-mutation-generates-vascular-abnormalities-correlated-with-neuronal-damage-in-a-mouse-model-of-hanac-syndrome
#3
Alix Trouillet, Henri Lorach, Elisabeth Dubus, Brahim El Mathari, Ivana Ivkovic, Julie Dégardin, Manuel Simonutti, Michel Paques, Xavier Guillonneau, Florian Sennlaub, José-Alain Sahel, Pierre Ronco, Emmanuelle Plaisier, Serge Picaud
: The HANAC syndrome is caused by mutations in the gene coding for collagen4a1, a major component of blood vessel basement membranes. Ocular symptoms include an increase in blood vessel tortuosity and occasional hemorrhages. To examine how vascular defects can affect neuronal function, we analyzed the retinal phenotype of a HANAC mouse model. Heterozygous mutant mice displayed both a thinning of the basement membrane in retinal blood vessels and in Bruch's membrane resulting in vascular leakage...
January 3, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28047432/su-g-iep1-11-resting-state-fluctuation-of-bold-signal-amplitude-for-mapping-cerebrovascular-reactivity-in-presurgical-functional-mri
#4
P Wang, P Hou, S Kesler, R Colen, A Kumar, S Prabhu, H Liu
PURPOSE: Cerebrovascular reactivity (CVR) MRI with hypercapnia challenges, such as a breath-hold (BH) task, has been proposed to indicate areas with neurovascular uncoupling potentials for presurgical functional MRI (fMRI). This study aimed to explore the use of resting-state (RS) fMRI, in particular, the RS fluctuation of amplitude (RSFA) for detecting the impaired CVR and compare with BH MRI in patients with gliomas. METHODS: The BH and RS fMRI from six patients as part of their presurgical fMRI studies were analyzed...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28038898/demographic-and-systemic-hemodynamic-influences-in-mechanisms-of-cerebrovascular-regulation-in-healthy-adults
#5
João Madureira, Pedro Castro, Elsa Azevedo
OBJECTIVES: A competent cerebrovascular regulation maintains an adequate cerebral blood flow by 3 major mechanisms: cerebral autoregulation (CA), vasomotor reactivity (VMR), namely to CO2, and neurovascular coupling (NVC). However, most studies generalize their results based on a response to a single parameter. Using a full battery of neurovascular stress tests, our study aims to evaluate the relationships among grades of CA, VMR, and NVC, and how their interplay is influenced by demographic and systemic hemodynamic factors...
December 27, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27882947/arginase-2-promotes-neurovascular-degeneration-during-ischemia-reperfusion-injury
#6
Esraa Shosha, Zhimin Xu, Harumasa Yokota, Alan Saul, Modesto Rojas, R William Caldwell, Ruth B Caldwell, S Priya Narayanan
Retinal ischemia is a major cause of visual impairment and blindness and is involved in various disorders including diabetic retinopathy, glaucoma, optic neuropathies and retinopathy of prematurity. Neurovascular degeneration is a common feature of these pathologies. Our lab has previously reported that the ureahydrolase arginase 2 (A2) is involved in ischemic retinopathies. Here, we are introducing A2 as a therapeutic target to prevent neurovascular injury after retinal ischemia/reperfusion (I/R) insult. Studies were performed with mice lacking both copies of A2 (A2(-/-)) and wild-type (WT) controls (C57BL6J)...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27876394/postnatal-irradiation-induced-hippocampal-neuropathology-cognitive-impairment-and-aging
#7
REVIEW
Feng Ru Tang, Weng Keong Loke, Boo Cheong Khoo
Irradiation of the brain in early human life may set abnormal developmental events into motion that last a lifetime, leading to a poor quality of life for affected individuals. While the effect of irradiation at different early developmental stages on the late human life has not been investigated systematically, animal experimental studies suggest that acute postnatal irradiation with ⩾0.1Gy may significantly reduce neurogenesis in the dentate gyrus and endotheliogenesis in cerebral vessels and induce cognitive impairment and aging...
November 19, 2016: Brain & Development
https://www.readbyqxmd.com/read/27869302/brain-function-is-linked-to-ldl-cholesterol-in-older-adults-with-cardiovascular-risk
#8
Liesel-Ann C Meusel, Nicole D Anderson, Matthew D Parrott, William Yuen, Ekaterina Tchistiakova, Bradley J MacIntosh, Sid Feldman, Carol E Greenwood
OBJECTIVES: To determine how cardiovascular risk is associated with working memory task performance and task-related suppression of default-mode network (DMN) activity in cognitively intact older adults. DESIGN: A cross-sectional functional magnetic resonance imaging study of older adults with cardiovascular risk factors. SETTING: Rotman Research Institute, Baycrest Health Sciences. PARTICIPANTS: Thirty older adults with cardiovascular risk factors...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27865779/impairment-of-neurovascular-coupling-in-type-1-diabetes-mellitus-in-rats-is-prevented-by-pancreatic-islet-transplantation-and-reversed-by-a-semi-selective-pkc-inhibitor
#9
Francesco Vetri, Meirigeng Qi, Haoliang Xu, Jose Oberholzer, Chanannait Paisansathan
Streptozotocin (STZ)-induced chronic hyperglycemia has a detrimental effect on neurovascular coupling, linked to increased PKC-mediated phosphorylation and PKC isoform expression changes. Here, we sought to determine whether: 1) selective PKC-α/β/γ inhibitor, GF109203X, could reverse the effects of chronic hyperglycemia on cerebrovascular reactivity; 2) pancreatic islet transplantation could prevent the development of cerebrovascular impairment seen in a rat model of Type 1 Diabetes. We studied the effect of GF109203X in diabetic (DM), non-diabetic (ND), and transplanted (TR) Lewis rats during either sciatic nerve stimulation (SNS) or the topical applications of the large-conductance Ca(2+)-operated K(+)(BKCa) channel opener, NS1619, or the K(+) inward rectifier (Kir) channel agonist, KCl...
January 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27864848/age-related-small-vessel-disease-a-potential-contributor-to-neurodegeneration-in-multiple-sclerosis
#10
REVIEW
Ruth Geraldes, Margaret M Esiri, Gabriele C DeLuca, Jacqueline Palace
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system wherein, after an initial phase of transient neurological defects, slow neurological deterioration due to progressive neuronal loss ensues. Age is a major determinant of MS progression onset and disability. Over the past years, several mechanisms have been proposed to explain the key drivers of neurodegeneration and disability accumulation in MS. However, the effect of commonly encountered age-related cerebral vessel disease, namely small vessel disease (SVD), has been largely neglected and constitutes the aim of this review...
November 19, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27817869/prevalence-and-risk-of-migraine-in-patients-with-rosacea-a-population-based-cohort-study
#11
Alexander Egeberg, Messoud Ashina, David Gaist, Gunnar H Gislason, Jacob P Thyssen
BACKGROUND: Rosacea features increased neurovascular reactivity; migraine is a complex neurologic disorder characterized by recurrent episodes of headache associated with nausea and increased sensitivity to light and sound. OBJECTIVE: We evaluated the prevalence and risk of new-onset migraine in patients with rosacea. METHODS: All Danish individuals 18 years of age or older were linked in nationwide registers. Adjusted hazard ratios (HRs) were estimated by Cox regression...
November 3, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27729477/blood-brain-barrier-disruption-and-neurovascular-unit-dysfunction-in-diabetic-mice-protection-with-the-mitochondrial-carbonic-anhydrase-inhibitor-topiramate
#12
Therese S Salameh, Gul N Shah, Tulin O Price, Melvin R Hayden, William A Banks
All forms of diabetes mellitus are characterized by chronic hyperglycemia, resulting in the development of a number of microvascular and macrovascular pathologies. Diabetes is also associated with changes in brain microvasculature, leading to dysfunction and ultimately disruption of the blood-brain barrier (BBB). These changes are correlated with a decline in cognitive function. In diabetes, BBB damage is associated with increased oxidative stress and reactive oxygen species. This occurs because of the increased oxidative metabolism of glucose caused by hyperglycemia...
December 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27664828/neurovascular-unit-remodelling-in-the-subacute-stage-of-stroke-recovery
#13
Evelyn M R Lake, Paolo Bazzigaluppi, James Mester, Lynsie A M Thomason, Rafal Janik, Mary Brown, JoAnne McLaurin, Peter L Carlen, Dale Corbett, Greg J Stanisz, Bojana Stefanovic
Brain plasticity following focal cerebral ischaemia has been observed in both stroke survivors and in preclinical models of stroke. Endogenous neurovascular adaptation is at present incompletely understood yet its potentiation may improve long-term functional outcome. We employed longitudinal MRI, intracranial array electrophysiology, Montoya Staircase testing, and immunofluorescence to examine function of brain vessels, neurons, and glia in addition to forelimb skilled reaching during the subacute stage of ischemic injury progression...
September 21, 2016: NeuroImage
https://www.readbyqxmd.com/read/27619153/binaural-blood-flow-control-by-astrocytes-listening-to-synapses-and-the-vasculature
#14
Anusha Mishra
Astrocytes are the most common glial cells in the brain with fine processes and endfeet that intimately contact both neuronal synapses and the cerebral vasculature. They play an important role in mediating neurovascular coupling (NVC) via several astrocytic Ca(2+) -dependent signalling pathways such as K(+) release through BK channels, and the production and release of arachidonic acid metabolites. They are also involved in maintaining the resting tone of the cerebral vessels by releasing ATP and COX-1 derivatives...
September 13, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27617449/vascular-endothelial-dysfunction-caused-by-oxidative-stress-is-a-predictor-factor-for-complications-of-obstructive-sleep-apnea-syndrome
#15
K Kilic, B Aktan, M Sedat-Sakat, A Kızıltunç, O Yoruk
Objective: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of upper airway obstruction that occur during sleep which leads to cardiovascular, neurovascular and metabolic diseases. The mechanisms of complications in these patients are unclear. In this report, we aimed to determine the cause of oxidative imbalance in patients with OSAS and to evaluate the vascular endothelial dysfunction as a suspect for complications of the disease. Materials and Methods: Fifty patients diagnosed as moderate or severe OSAS (AHI > 15) by polysomnography and 50 healthy volunteers are included in the study...
February 15, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27604741/determination-of-vascular-reactivity-of-middle-cerebral-arteries-from-stroke-and-spinal-cord-injury-animal-models-using-pressure-myography
#16
Mohammad A Anwar, Ali H Eid
Stroke and other neurovascular derangements are main causes of global death. They, along with spinal cord injuries, are responsible for being the principal cause of disability due to neurological and cognitive problems. These problems then lead to a burden on scarce financial resources and societal care facilities as well as have a profound effect on patients' families. The mechanism of action in these debilitating diseases is complex and unclear. An important component of these problems arises from derangement of blood vessels, such as blockage due to clotting/embolism, endothelial dysfunction, and overreactivity to contractile agents, as well as alteration in endothelial permeability...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27583476/effect-of-linagliptin-on-vascular-function-a-randomized-placebo-controlled-study
#17
Dimitrios Baltzis, Jody R Dushay, Jordan Loader, Jim Wu, Robert L Greenman, Matthieu Roustit, Aristidis Veves
CONTEXT: The dipeptidyl peptidase-4 inhibitor, linagliptin, possesses pleiotropic vasodilatory, antioxidant, and anti-inflammatory properties in animals, independent of its glucose-lowering properties. Although large, randomized clinical trials are being conducted to better evaluate the efficacy and safety of linagliptin on cardiovascular outcomes, little is known about its effects on vascular function in humans. OBJECTIVE: This study sought to evaluate the effect of linagliptin on surrogates of vascular and mitochondrial function...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27572110/impact-of-abnormal-cerebrovascular-reactivity-on-bold-fmri-a-preliminary-investigation-of-moyamoya-disease
#18
Erin L Mazerolle, Yuhan Ma, David Sinclair, G Bruce Pike
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies of patients with cerebrovascular disease have largely ignored the confounds associated with abnormal cerebral blood flow, vascular reactivity and neurovascular coupling. We studied BOLD fMRI activation and cerebrovascular reactivity in moyamoya disease. To characterize the impact of remote vascular demands on BOLD fMRI measurements, we varied the vascular territories engaged by manipulating the experimental task performed by the participants...
August 30, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27558201/fingolimod-fty720-reduces-cortical-infarction-and-neurological-deficits-during-ischemic-stroke-through-potential-maintenance-of-microvascular-patency
#19
Michael K Schuhmann, Miloš Krstić, Christoph Kleinschnitz, Felix Fluri
Fingolimod (FTY720) a functional sphingosine-1-phosphate receptor 1 (S1P1) antagonist reduces infarct volume and improves neurological deficits in different rodent stroke models by modulating inflammatory and immune processes. However, studies on FTY720 regarding its non-immunological efficacy on ischemic cerebral tissue are sparse. Here we investigated whether FTY720 has cytoprotective and restorative properties following ischemic stroke in mice. Male C57Bl/6 mice received FTY720 (1mg/kg) or a vehicle solution intraperitoneally immediately prior to transient middle cerebral artery occlusion (tMCAO; 30 min...
August 23, 2016: Current Neurovascular Research
https://www.readbyqxmd.com/read/27485237/effects-of-sildenafil-on-cerebrovascular-reactivity-in-patients-with-becker-muscular-dystrophy
#20
Ulrich Lindberg, Nanna Witting, Stine Lundgaard Jørgensen, John Vissing, Egill Rostrup, Henrik Bo Wiberg Larsson, Christina Kruuse
Patients suffering from Becker muscular dystrophy (BMD) have dysfunctional dystrophin proteins and are deficient in neuronal nitric oxide synthase (nNOS) in muscles. This causes functional ischemia and contributes to muscle wasting. Similar functional ischemia may be present in brains of patients with BMD, who often have mild cognitive impairment, and nNOS may be important for the regulation of the microvascular circulation in the brain. We hypothesized that treatment with sildenafil, a phosphodiesterase type 5 inhibitor that potentiates nitric oxide responses, would augment both the blood oxygen level-dependent (BOLD) response and cerebral blood flow (CBF) in patients with BMD...
January 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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