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neurovascular reactivity

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https://www.readbyqxmd.com/read/29878868/effect-of-healthy-ageing-on-cerebral-blood-flow-co-2-reactivity-and-neurovascular-coupling-during-exercise
#1
Daniela Nowak-Flück, Philip N Ainslie, Anthony Richard Bain, Amar Ahmed, Kevin W Wildfong, Laura Emily Morris, Aaron A Phillips, James P Fisher
We sought to make the first comparisons of duplex Doppler ultrasonography derived measures of cerebral blood flow during exercise in young and older individuals, and to assess whether healthy ageing influences the effect of exercise on neurovascular coupling (NVC) and cerebral vascular reactivity to changes in carbon dioxide (CVRCO2 ). In ten healthy young (23{plus minus}2yr; mean{plus minus}SD) and nine healthy older (66{plus minus}3yr) individuals, internal carotid artery (ICA) and vertebral artery (VA) blood flows were concurrently measured, along with middle and posterior cerebral artery mean blood velocity (MCAvmean and PCAvmean)...
June 7, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29777753/characterization-of-impaired-cerebrovascular-structure-in-app-ps1-mouse-brains
#2
Kee-Chan Ahn, Cameron R Learman, Gary L Dunbar, Panchanan Maiti, Won-Cheoul Jang, Hyeon-Cheol Cha, Mee-Sook Song
Alzheimer's disease (AD) is defined by senile plaques, tauopathy and neuronal cell death in specific area of the brain. Recent studies suggest that neurovascular dysfunction may be an integral part of AD pathogenesis, contributing to the onset and development of AD pathologies such as neuronal death, inflammatory response, and breakdown of blood brain barrier (BBB). In addition, vascular complications caused by age-related metabolic diseases such as diabetes and high blood pressure have high incidence in development of dementia and AD...
May 16, 2018: Neuroscience
https://www.readbyqxmd.com/read/29757409/secretogranin-ii-plays-a-critical-role-in-zebrafish-neurovascular-modeling
#3
Binbin Tao, Hongling Hu, Kimberly Mitchell, Ji Chen, Haibo Jia, Zuoyan Zhu, Vance L Trudeau, Wei Hu
Secretoneurin (SN) is a neuropeptide derived from specific proteolytic processing of the precursor secretogranin II (SgII). In zebrafish and other teleosts, there are two paralogs named sgIIa and sgIIb. Our results showed that neurons expressing sgIIb were aligned with central arteries in the hindbrain, demonstrating a close neurovascular association. Both sgIIb-/- and sgIIa-/-/sgIIb-/- mutant embryos were defective in hindbrain central artery development due to impairment of migration and proliferation of central artery cells...
May 11, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29728852/glial-cells-shape-pathology-and-repair-after-spinal-cord-injury
#4
REVIEW
Andrew D Gaudet, Laura K Fonken
Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he correctly surmised that microglia in pathologic central nervous system (CNS) were "voracious monsters" that helped clean the tissue. Although these historical predictions were remarkably accurate, innovative technologies have revealed novel molecular, cellular, and dynamic physiologic aspects of CNS glia. In this review, we integrate recent findings regarding the roles of glia and glial interactions in healthy and injured spinal cord...
May 4, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29687902/impact-of-metabolic-diseases-on-cerebral-circulation-structural-and-functional-consequences
#5
Maha Coucha, Mohammed Abdelsaid, Rebecca Ward, Yasir Abdul, Adviye Ergul
Metabolic diseases including obesity, insulin resistance, and diabetes have profound effects on cerebral circulation. These diseases not only affect the architecture of cerebral blood arteries causing adverse remodeling, pathological neovascularization, and vasoregression but also alter the physiology of blood vessels resulting in compromised myogenic reactivity, neurovascular uncoupling, and endothelial dysfunction. Coupled with the disruption of blood brain barrier (BBB) integrity, changes in blood flow and microbleeds into the brain rapidly occur...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29681886/importance-of-collateralization-in-patients-with-large-artery-intracranial-occlusive-disease-long-term-longitudinal-assessment-of-cerebral-hemodynamic-function
#6
Larissa McKetton, Lakshmikumar Venkatraghavan, Julien Poublanc, Olivia Sobczyk, Adrian P Crawley, Casey Rosen, Frank L Silver, James Duffin, Joseph A Fisher, David J Mikulis
Patients with large artery intracranial occlusive disease (LAICOD) are at risk for both acute ischemia and chronic hypoperfusion. Collateral circulation plays an important role in prognosis, and imaging plays an essential role in diagnosis, treatment planning, and prognosis of patients with LAICOD. In addition to standard structural imaging, assessment of cerebral hemodynamic function is important to determine the adequacy of collateral supply. Among the currently available methods of assessment of cerebral hemodynamic function, measurement of cerebrovascular reactivity (CVR) using blood oxygen level-dependent (BOLD) MRI and precisely controlled CO2 has shown to be a safe, reliable, reproducible, and clinically useful method for long-term assessment of patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29593520/iclinfmri-software-for-integrating-functional-mri-techniques-in-presurgical-mapping-and-clinical-studies
#7
Ai-Ling Hsu, Ping Hou, Jason M Johnson, Changwei W Wu, Kyle R Noll, Sujit S Prabhu, Sherise D Ferguson, Vinodh A Kumar, Donald F Schomer, John D Hazle, Jyh-Horng Chen, Ho-Ling Liu
Task-evoked and resting-state (rs) functional magnetic resonance imaging (fMRI) techniques have been applied to the clinical management of neurological diseases, exemplified by presurgical localization of eloquent cortex, to assist neurosurgeons in maximizing resection while preserving brain functions. In addition, recent studies have recommended incorporating cerebrovascular reactivity (CVR) imaging into clinical fMRI to evaluate the risk of lesion-induced neurovascular uncoupling (NVU). Although each of these imaging techniques possesses its own advantage for presurgical mapping, a specialized clinical software that integrates the three complementary techniques and promptly outputs the analyzed results to radiology and surgical navigation systems in a clinical format is still lacking...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29580963/neurovascular-coupling-during-visual-stimulation-in-multiple-sclerosis-a-meg-fmri-study
#8
Rachael Stickland, Marek Allen, Lorenzo Magazzini, Krish D Singh, Richard G Wise, Valentina Tomassini
The process of neurovascular coupling ensures that increases in neuronal activity are fed by increases in cerebral blood flow. Evidence suggests that neurovascular coupling may be impaired in Multiple Sclerosis (MS) due to a combination of brain hypoperfusion, altered cerebrovascular reactivity and oxygen metabolism, and altered levels of vasoactive compounds. Here, we tested the hypothesis that neurovascular coupling is impaired in MS. We characterized neurovascular coupling as the relationship between changes in neuronal oscillatory power within the gamma frequency band (30-80 Hz), as measured by magnetoencephalography (MEG), and associated hemodynamic changes (blood oxygenation level dependent, BOLD, and cerebral blood flow, CBF) as measured by functional MRI...
March 23, 2018: Neuroscience
https://www.readbyqxmd.com/read/29570780/effects-of-ischemic-post-conditioning-on-neuronal-vegf-regulation-and-microglial-polarization-in-a-rat-model-of-focal-cerebral-ischemia
#9
Elga Esposito, Kazuhide Hayakawa, Bum Ju Ahn, Su Jing Chan, Changhong Xing, Anna C Liang, Kyu-Won Kim, Ken Arai, Eng H Lo
Ischemic postconditioning is increasingly being investigated as a therapeutic approach for cerebral ischemia. However, the majority of studies are focused on the acute protection of neurons per se. Whether and how postconditioning affects multiple cells in the recovering neurovascular unit remains to be fully elucidated. Here, we asked whether postconditioning may modulate help-me signaling between injured neurons and reactive microglia. Rats were subjected to 100 min of focal cerebral ischemia, then randomized into a control versus postconditioning group...
March 23, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29553570/skeletal-muscle-neurovascular-coupling-oxidative-capacity-and-microvascular-function-with-one-stop-shop-near-infrared-spectroscopy
#10
Ryan Rosenberry, Susie Chung, Michael D Nelson
Exercise represents a major hemodynamic stress that demands a highly coordinated neurovascular response in order to match oxygen delivery to metabolic demand. Reactive hyperemia (in response to a brief period of tissue ischemia) is an independent predictor of cardiovascular events and provides important insight into vascular health and vasodilatory capacity. Skeletal muscle oxidative capacity is equally important in health and disease, as it determines the energy supply for myocellular processes. Here, we describe a simple, non-invasive approach using near-infrared spectroscopy to assess each of these major clinical endpoints (reactive hyperemia, neurovascular coupling, and muscle oxidative capacity) during a single clinic or laboratory visit...
February 20, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29466947/stroke-as-an-atypical-initial-presentation-of-giant-cell-arteritis
#11
Tharsika Kuganesan, Allen R Huang
BACKGROUND: Giant cell arteritis (GCA) is an immune mediated inflammatory disease of medium and large arteries which afflicts older people. The classical presentation features include: headache, visual disturbances, and jaw claudication. Patients diagnosed with GCA have also been observed to be at higher risk for the subsequent development of strokes. CASE PRESENTATION: We describe a case of an 84-year old right-handed man who presented to hospital with dysarthria, dysphagia, right-sided facial drop, a history of generalized weakness and multiple falls...
February 21, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29447850/impact-of-baseline-co-2-on-blood-oxygenation-level-dependent-mri-measurements-of-cerebrovascular-reactivity-and-task-evoked-signal-activation
#12
Christiaan Hendrik Bas van Niftrik, Marco Piccirelli, Oliver Bozinov, Nicolai Maldaner, Catherine Strittmatter, Athina Pangalu, Antonios Valavanis, Luca Regli, Jorn Fierstra
Neurovascular coupling describes the cascade between neuronal activity and subsequent Blood-Oxygenation-Level-Dependent (BOLD) signal increase. Based on this premise, the correlation of this BOLD signal increase with a particular task, such as finger-tapping, is used to map neuronal activation. This signal increase may be dampened in brain areas exhibiting impaired cerebrovascular reactivity (BOLD-CVR), leading to false negative activation. Blood-oxygenation-level-dependent (BOLD) cerebrovascular reactivity (CVR) has also been used to optimize task evoked BOLD signal changes...
June 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29432609/impaired-cerebral-hemodynamics-and-frailty-in-patients-with-cardiovascular-disease
#13
Miri Lutski, Salo Haratz, Galit Weinstein, Uri Goldbourt, David Tanne
Background: Recent studies suggest that impaired cerebrovascular reactivity (CVR), a marker of cerebral microvascular damage, is associated with a higher risk of stroke, cognitive decline and mortality. We tested whether abnormal cerebrovascular status is associated with late-life frailty among men with pre-existing cardiovascular disease. Methods: A subset of 327 men (mean age at baseline 56.7±6.5 years) who previously participated in the Bezafibrate Infarction Prevention (BIP) trial (1990-1997) and then in the BIP Neurocognitive study underwent a neurovascular evaluation 14...
February 8, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29405550/treatment-with-the-mitochondrial-targeted-antioxidant-peptide-ss-31-rescues-neurovascular-coupling-responses-and-cerebrovascular-endothelial-function-and-improves-cognition-in-aged-mice
#14
Stefano Tarantini, Noa M Valcarcel-Ares, Andriy Yabluchanskiy, Gabor A Fulop, Peter Hertelendy, Tripti Gautam, Eszter Farkas, Aleksandra Perz, Peter S Rabinovitch, William E Sonntag, Anna Csiszar, Zoltan Ungvari
Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to age-related decline of higher cortical functions. There is increasing evidence showing that mitochondrial oxidative stress plays a critical role in a range of age-related cellular impairments, but its role in neurovascular uncoupling remains unexplored...
April 2018: Aging Cell
https://www.readbyqxmd.com/read/29382846/a-novel-human-induced-pluripotent-stem-cell-blood-brain-barrier-model-applicability-to-study-antibody-triggered-receptor-mediated-transcytosis
#15
Maria Ribecco-Lutkiewicz, Caroline Sodja, Julie Haukenfrers, Arsalan S Haqqani, Dao Ly, Peter Zachar, Ewa Baumann, Marguerite Ball, Jez Huang, Marina Rukhlova, Marzia Martina, Qing Liu, Danica Stanimirovic, Anna Jezierski, Mahmud Bani-Yaghoub
We have developed a renewable, scalable and transgene free human blood-brain barrier model, composed of brain endothelial cells (BECs), generated from human amniotic fluid derived induced pluripotent stem cells (AF-iPSC), which can also give rise to syngeneic neural cells of the neurovascular unit. These AF-iPSC-derived BECs (i-BEC) exhibited high transendothelial electrical resistance (up to 1500 Ω cm2 ) inducible by astrocyte-derived molecular cues and retinoic acid treatment, polarized expression of functional efflux transporters and receptor mediated transcytosis triggered by antibodies against specific receptors...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29373286/trpc-proteins-contribute-to-development-of-diabetic-retinopathy-and-regulate-glyoxalase-1-activity-and-methylglyoxal-accumulation
#16
Robin Sachdeva, Andrea Schlotterer, Dagmar Schumacher, Christin Matka, Ilka Mathar, Nadine Dietrich, Rebekka Medert, Ulrich Kriebs, Jihong Lin, Peter Nawroth, Lutz Birnbaumer, Thomas Fleming, Hans-Peter Hammes, Marc Freichel
OBJECTIVE: Diabetic retinopathy (DR) is induced by an accumulation of reactive metabolites such as ROS, RNS, and RCS species, which were reported to modulate the activity of cation channels of the TRPC family. In this study, we use Trpc1/4/5/6-/- compound knockout mice to analyze the contribution of these TRPC proteins to diabetic retinopathy. METHODS: We used Nanostring- and qPCR-based analysis to determine mRNA levels of TRPC channels in control and diabetic retinae and retinal cell types...
March 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29320772/a-perfect-storm-the-role-of-the-mammalian-target-of-rapamycin-mtor-in-cerebrovascular-dysfunction-of-alzheimer-s-disease-a-mini-review
#17
Candice E Van Skike, Veronica Galvan
Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has a key role in the regulation of metabolism, but some mTOR-dependent mechanisms are uniquely specific to the regulation of cerebrovascular function...
2018: Gerontology
https://www.readbyqxmd.com/read/29285816/arterialized-collateral-capillaries-progress-from-nonreactive-to-capable-of-increasing-perfusion-in-an-ischemic-arteriolar-tree
#18
Kenneth H Gouin, Sara K Hellstrom, Lindsay E Clegg, Josh Cutts, Feilim Mac Gabhann, Trevor R Cardinal
OBJECTIVE: CCA, outward remodeling of capillaries that anastomose 2 arteriolar trees with different parent feed arteries, may represent a therapeutic target for patients who lack collaterals. ACCs can reperfuse an ischemic tree, but their functional capacity is unknown. Therefore, we determined whether ACCs mature into resistance vessels that regulate blood flow following arterial occlusion. METHODS: We ligated the lateral spinotrapezius feed artery in Balb/C mice, which induces CCA...
April 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29162554/sustained-administration-of-corticosterone-at-stress-like-levels-after-stroke-suppressed-glial-reactivity-at-sites-of-thalamic-secondary-neurodegeneration
#19
Katarzyna Zalewska, Giovanni Pietrogrande, Lin Kooi Ong, Mahmoud Abdolhoseini, Murielle Kluge, Sarah J Johnson, Frederick R Walker, Michael Nilsson
Secondary neurodegeneration (SND) is an insidious and progressive condition involving the death of neurons in regions of the brain that were connected to but undamaged by the initial stroke. Our group have published compelling evidence that exposure to psychological stress can significantly exacerbate the severity SND, a finding that has considerable clinical implications given that stroke-survivors often report experiencing high and unremitting levels of psychological stress. It may be possible to use one or more targeted pharmacological approaches to limit the negative effects of stress on the recovery process but in order to move forward with this approach the most critical stress signals have to be identified...
March 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29123083/identification-of-a-peptide-recognizing-cerebrovascular-changes-in-mouse-models-of-alzheimer-s-disease
#20
Aman P Mann, Pablo Scodeller, Sazid Hussain, Gary B Braun, Tarmo Mölder, Kadri Toome, Rajesh Ambasudhan, Tambet Teesalu, Stuart A Lipton, Erkki Ruoslahti
Cerebrovascular changes occur in Alzheimer's disease (AD). Using in vivo phage display, we searched for molecular markers of the neurovascular unit, including endothelial cells and astrocytes, in mouse models of AD. We identified a cyclic peptide, CDAGRKQKC (DAG), that accumulates in the hippocampus of hAPP-J20 mice at different ages. Intravenously injected DAG peptide homes to neurovascular unit endothelial cells and to reactive astrocytes in mouse models of AD. We identified connective tissue growth factor (CTGF), a matricellular protein that is highly expressed in the brain of individuals with AD and in mouse models, as the target of the DAG peptide...
November 10, 2017: Nature Communications
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