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https://www.readbyqxmd.com/read/29301900/complete-genome-sequence-of-escherichia-coli-phage-apc_jm3-2-isolated-from-a-chicken-cecum
#1
Jayne Mullally, Stephen R Stockdale, Muireann K Smith, Lorraine A Draper, Paul R Ross, Colin Hill
Avian pathogenic Escherichia coli (APEC) bacteria are a significant challenge to the poultry industry. Bacteriophages (phages) have the potential to control APEC strains, increasing animal welfare and economic productivity. Here, we report the isolation of an E. coli-infecting phage, APC_JM3.2, isolated from the cecum of a broiler chicken in Ireland.
January 4, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29250890/asian-pacific-endodontic-confederation-apec-report
#2
Sanjay Miglani
No abstract text is available yet for this article.
December 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29184361/phenotypic-and-genotypic-characterization-of-antimicrobial-susceptibility-of-avian-pathogenic-escherichia-coli-isolated-from-broiler-chickens
#3
Gamal Younis, Amal Awad, Nada Mohamed
Aim: Avian pathogenic Escherichia coli (APEC) is pathogenic strains of E. coli that are responsible for one of the most common bacterial diseases affecting poultry worldwide. This study was designed to determine the occurrence, antibiotic resistance profile, and antibiotic resistance genes of E. coli isolated from diseased and freshly dead broilers. Materials and Methods: In that context, a total of 200 broilers samples were examined by standard microbiological techniques for isolation of E...
October 2017: Veterinary World
https://www.readbyqxmd.com/read/29164427/virulence-traits-of-avian-pathogenic-apec-and-fecal-afec-e-coli-isolated-from-broiler-chickens-in-algeria
#4
Lounis Mohamed, Zhao Ge, Li Yuehua, Gao Yubin, Kaidi Rachid, Oumouna Mustapha, Wang Junwei, Oumouna Karine
Avian pathogenic E. coli (APEC) is the etiologic agent of avian colibacillosis, the most common disease responsible for chicken morbidity in the world. Although multiple virulence-associated factors were identified, their prevalence in Algeria is still poorly known. In the present research, 92 avian pathogenic E. coli (APEC) isolates were recovered from broilers with clinical signs and lesions of colibacillosis. In addition, 32 E. coli isolates collected from feces of healthy birds (AFEC) were included for comparison...
November 21, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29150834/il-22-neutralizing-autoantibodies-impair-fungal-clearance-in-murine-oropharyngeal-candidiasis-model
#5
Rudolf Bichele, Jaanika Kärner, Kai Truusalu, Imbi Smidt, Reet Mändar, Heather R Conti, Sarah L Gaffen, Pärt Peterson, Martti Laan, Kai Kisand
Protection against mucocutaneous candidiasis depends on the T helper (Th)17 pathway, as gene defects affecting its integrity result in inability to clear Candida albicans infection on body surfaces. Moreover, autoantibodies neutralizing Th17 cytokines have been related to chronic candidiasis in a rare inherited disorder called autoimmune polyendocriopathy candidiasis ectodermal dystrophy (APECED) caused by mutations in autoimmune regulator (AIRE) gene. However, the direct pathogenicity of these autoantibodies has not yet been addressed...
November 17, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29129473/dominant-negative-loss-of-function-arises-from-a-second-more-frequent-variant-within-the-sand-domain-of-autoimmune-regulator-aire
#6
Jordan K Abbott, Yu-San Huoh, Paul R Reynolds, Liping Yu, Marian Rewers, Monica Reddy, Mark S Anderson, Sun Hur, Erwin W Gelfand
A genetic variant in the SAND domain of autoimmune regulator (AIRE), R247C, was identified in a patient with type I diabetes mellitus (T1DM) and his mother with rheumatoid arthritis. In vitro, the variant dominantly inhibited AIRE; however, typical features of Autoimmune Polyendocrinopathy Candidiasis and Ectodermal Dysplasia (APECED) were not seen in the subjects. Rather, early manifestation of autoimmunity appeared to be dependent on additional genetic factors. On a population level, diverse variants were identified in this region...
November 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29111323/the-role-of-the-ptsi-gene-on-ai-2-internalization-and-pathogenesis-of-avian-pathogenic-escherichia-coli
#7
Xiaoka Wu, Xiaolong Lv, Jinye Lu, Shengqing Yu, Yawei Jin, Jiangang Hu, Jiakun Zuo, Rongsheng Mi, Yan Huang, Kezong Qi, Zhaoguo Chen, Xiangan Han
The LuxS/AI-2 quorum sensing mechanism can regulate the physiological functions of avian pathogenic Escherichia coli (APEC) through internalization of the small molecule autoinducer-2 (AI-2). The ptsI gene encodes enzyme I, which participates in the phosphotransferase system (PTS) that regulates the virulence and AI-2 internalization of bacteria. The aim of the present study was to determine the effect of ptsI on AI-2 internalization and other pathogenesis process in APEC using a ptsI mutant of the APEC strain DE17 (serotype O2), namely DE17ΔptsI...
October 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29102113/different-activated-methyl-cycle-pathways-affect-the-pathogenicity-of-avian-pathogenic-escherichia-coli
#8
Da Xu, Jiakun Zuo, Zhaoguo Chen, Xiaolong Lv, Jiangang Hu, Xiaoka Wu, Kezong Qi, Rongsheng Mi, Yan Huang, Jingfeng Miao, Wei Jiang, Shaohui Wang, Chengming Wang, Xiangan Han
The activated methyl cycle (AMC) regulates the cellular levels of S-adenosyl-l-homocysteine (SAH) in bacteria, which plays a crucial role in bacterial pathogenicity. There are two AMC pathways in bacteria: one is a two-step reaction pathway (named the LuxS/Pfs pathway) in which LuxS and Pfs catalyze the conversion of SAH to l-homocysteine and autoinducer-2 (AI-2), and the other is a one-step reaction (named the SahH pathway) mediated by S-adenosyl-l-homocysteine hydrolase (SahH), which completes this cycle without producing AI-2...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29075235/commentary-comparative-analysis-of-phylogenetic-assignment-of-human-and-avian-expec-and-fecal-commensal-escherichia-coli-using-the-previous-and-revised-clermont-phylogenetic-typing-methods-and-its-impact-on-avian-pathogenic-escherichia-coli-apec-classification
#9
COMMENT
https://www.readbyqxmd.com/read/29040287/antimicrobial-activity-of-carbon-monoxide-releasing-molecule-mn-co-3-tpa-%C3%AE%C2%BA3n-br-versus-multidrug-resistant-isolates-of-avian-pathogenic-escherichia-coli-and-its-synergy-with-colistin
#10
Jonathan Betts, Christopher Nagel, Ulrich Schatzschneider, Robert Poole, Robert M La Ragione
Antimicrobial resistance is a growing global concern in human and veterinary medicine, with an ever-increasing void in the arsenal of clinicians. Novel classes of compounds including carbon monoxoide-releasing molecules (CORMs), for example the light-activated metal complex [Mn(CO)3(tpa-κ3N)]Br, could be used as alternatives/to supplement traditional antibacterials. Avian pathogenic Escherichia coli (APEC) represent a large reservoir of antibiotic resistance and can cause serious clinical disease in poultry, with potential as zoonotic pathogens, due to shared serotypes and virulence factors with human pathogenic E...
2017: PloS One
https://www.readbyqxmd.com/read/28924584/an-evaluation-of-the-virulence-and-adherence-properties-of-avian-pathogenic-escherichia-coli
#11
Kyle LeStrange, Sarah M Markland, Dallas G Hoover, Manan Sharma, Kalmia E Kniel
Avian pathogenic E. coli (APEC) cause disease primarly in poultry; however, the link between APEC and infections in humans is questionable. In this current study, a total of 100 APEC strains isolated from chickens in Delmarva were evaluated for the presence of virulence genes to investigate their zoonotic potential in humans. A total of 28 isolates possessed one Enterohaemorrhagic E. coli (EHEC) virulence factor each and 87 isolates possessed up to 5 extraintestinal pathogenic E. coli (ExPEC) virulence factors...
December 2017: One Health
https://www.readbyqxmd.com/read/28911037/a-biologically-conjugated-polysaccharide-vaccine-delivered-by-attenuated-salmonella-typhimurium-provides-protection-against-challenge-of-avian-pathogenic-escherichia-coli-o1-infection
#12
Yue Han, Qing Liu, Jie Yi, Kang Liang, Yunan Wei, Qingke Kong
Avian pathogenic Escherichia coli (APEC) causes avian airsacculitis and colibacillosis, resulting in significant economic loss to the poultry industry. O1, O2 and O78 are the three predominant serotypes. O-antigen of lipopolysaccharide is serotype determinant and highly immunogenic, and O-antigen polysaccharide-based vaccines have great potential for preventing bacterial infections. In this study, we utilized a novel yeast/bacterial shuttle vector pSS26 to clone the 10.8 kb operon synthesizing APEC O1 O-antigen polysaccharide...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28895515/escherichia-coli-type-iii-secretion-system-2-regulator-etra-promotes-virulence-of-avian-pathogenic-escherichia-coli
#13
Shaohui Wang, Xuan Xu, Xin Liu, Dong Wang, Hua Liang, Xiaojun Wu, Mingxing Tian, Chan Ding, Guijun Wang, Shengqing Yu
The Escherichia coli type III secretion system 2 (ETT2) is found in most E. coli strains, including pathogenic and commensal strains. Although many ETT2 gene clusters carry multiple genetic mutations or deletions, ETT2 is known to be involved in bacterial virulence. In enterohaemorrhagic E. coli (EHEC), ETT2 affects adhesion through the regulator EtrA, which regulates transcription and secretion of the type III secretion system (T3SS) encoded by the locus of enterocyte effacement (LEE). To date, no studies have been conducted on the role of EtrA in the virulence of avian pathogenic E...
September 12, 2017: Microbiology
https://www.readbyqxmd.com/read/28878764/molecular-cloning-characterization-and-anti-avian-pathogenic-escherichia-coli-innate-immune-response-of-the-cherry-valley-duck-ciita-gene
#14
Rong Li, Mengjiao Guo, Jing Lin, Tongjie Chai, Liangmeng Wei
Class II major histocompatibility complex (MHC-II) transactivator (CIITA) is a member of the pattern recognition receptor in cytoplasm, which is involved in host innate immune responses. In this study, the full-length cDNA of Cherry Valley duck CIITA (duCIITA) was cloned from the spleen of healthy Cherry Valley ducks for the first time. The CDs of duCIITA have 3648 bp and encode 1215 amino acids. The homology analysis of CIITAs amino acid sequence showed that the duCIITA has the highest identity with the Anas platyrhynchos (94...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28871661/update-on-aire-and-thymic-negative-selection
#15
REVIEW
Geraldo Aleixo Passos, Cesar A Speck-Hernandez, Amanda Freire Assis, Daniella A Mendes-da-Cruz
Twenty years ago, the autoimmune regulator (Aire) gene was associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), cloned and sequenced. Its importance goes beyond its link with human autoimmune disease. Aire identification opened new perspectives to better understand the molecular basis of central tolerance and self-non-self-distinction, the main properties of the immune system. During these two last decades, a growing number of immunologists and molecular geneticists have made important discoveries about the function of Aire, which is essentially a pleiotropic gene...
September 4, 2017: Immunology
https://www.readbyqxmd.com/read/28865220/frequency-of-iss-and-irp2-genes-by-pcr-method-in-escherichia-coli-isolated-from-poultry-with-colibacillosis-in-comparison-with-healthy-chicken-in-poultry-farms-of-zabol-south-east-of-iran
#16
M S Sadeghi Bonjar, S Salari, M Jahantigh, A Rashki
There is no special trait for differentiation of Avian Pathogenic Escherichia coli from Avian Fecal Escherichia coli. This investigation is aimed, as a case control study, to evaluate and compare the frequency of iss and irp2 in 43 AFEC strains and also 40 and 56 E. coli strains isolated from the liver and kidney of chickens with colibacillosis, respectively, farmed in Zabol, as a border region of Iran, by PCR. 86.9% and 37.2% of isolates collected from chickens with colibacillosis and feces samples obtained from healthy chickens were positive for iss gene, respectively (P<0...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28862690/variations-in-the-rate-of-infestations-of-dogs-with-zoonotic-nematodes-and-the-contamination-of-soil-in-different-environments
#17
Maria Bernadeta Studzińska, Marta Demkowska-Kutrzepa, Anna Borecka, Michał Meisner, Krzysztof Tomczuk, Monika Roczeń-Karczmarz, Teresa Kłapeć, Zahrai Abbass, Alicja Cholewa
Companion animals are an important aspect in human life. However, they may also be considered a source of pathogens. An example of zoonotic parasitoses is toxocarosis or cutaneous larva migrans (CLM). The aim of the study was to detect zoonotic nematodes of dogs living in different areas and the intensity of contamination in parasite polluted environments that are hazardous to human health. The fecal samples were examined using standard flotation and decantation methods as well as McMaster's quantitative technique...
September 1, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28861084/autoantibody-repertoire-in-apeced-patients-targets-two-distinct-subgroups-of-proteins
#18
Dmytro Fishman, Kai Kisand, Christina Hertel, Mike Rothe, Anu Remm, Maire Pihlap, Priit Adler, Jaak Vilo, Aleksandr Peet, Antonella Meloni, Katarina Trebusak Podkrajsek, Tadej Battelino, Øyvind Bruserud, Anette S B Wolff, Eystein S Husebye, Nicolas Kluger, Kai Krohn, Annamari Ranki, Hedi Peterson, Adrian Hayday, Pärt Peterson
High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies, including some which are pathognomonic for major autoimmune diseases. AIRE deficiency severely reduces thymic expression of gene-products ordinarily restricted to discrete peripheral tissues, and developing T cells reactive to those gene-products are not inactivated during their development...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28837660/a-recombinant-multi-antigen-vaccine-with-broad-protection-potential-against-avian-pathogenic-escherichia-coli
#19
Angelica Van Goor, Zachary R Stromberg, Melha Mellata
Chickens are a major source of protein worldwide, yet infectious diseases continue to threaten the poultry industry. Avian pathogenic Escherichia coli (APEC), a subgroup of extraintestinal pathogenic E. coli (ExPEC), causes colibacillosis in chickens resulting in economic loss because of treatment, condemnation of products, and death. In this study, we evaluated a recombinant antigens (rAg) vaccine combining common ExPEC surface proteins EtsC, OmpA, OmpT, and TraT for broad protective potential against APEC infections in chickens...
2017: PloS One
https://www.readbyqxmd.com/read/28833960/apec-news-june-2017
#20
Sanjay Miglani, Hyeon-Cheol Henry Kim, James Brichko
No abstract text is available yet for this article.
August 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
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