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https://www.readbyqxmd.com/read/28093116/captive-and-free-living-urban-pigeons-columba-livia-from-brazil-as-carriers-of-multidrug-resistant-pathogenic-escherichia-coli
#1
Clarissa A Borges, Renato P Maluta, Lívia G Beraldo, Marita V Cardozo, Elisabete A L Guastalli, Subhashinie Kariyawasam, Chitrita DebRoy, Fernando A Ávila
Thirty Escherichia coli isolates from captive and free-living pigeons in Brazil were characterised. Virulence-associated genes identified in pigeons included those which occur relatively frequently in avian pathogenic E. coli (APEC) from commercial poultry worldwide. Eleven of 30 E. coli isolates from pigeons, belonging mainly to B1 and B2 phylogenetic groups, had high or intermediate pathogenicity for 1-day-old chicks. The frequency of multi-drug resistant (MDR) E. coli in captive pigeons was relatively high and included one isolate positive for the extended-spectrum β-lactamase (ESBL) gene blaCTX-M-8...
January 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28090315/chronic-mucocutaneous-candidiasis-disease-associated-with-inborn-errors-of-il-17-immunity
#2
REVIEW
Satoshi Okada, Anne Puel, Jean-Laurent Casanova, Masao Kobayashi
Chronic mucocutaneous candidiasis (CMC) is characterized by recurrent or persistent infections affecting the nails, skin and oral and genital mucosae caused by Candida spp., mainly Candida albicans. CMC is an infectious phenotype in patients with inherited or acquired T-cell deficiency. Patients with autosomal-dominant (AD) hyper IgE syndrome (HIES), AD signal transducer and activator of transcription 1 (STAT1) gain-of-function, autosomal-recessive (AR) deficiencies in interleukin (IL)-12 receptor β1 (IL-12Rβ1), IL-12p40, caspase recruitment domain-containing protein 9 (CARD9) or retinoic acid-related orphan receptor γT (RORγT) or AR autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) develop CMC as a major infectious phenotype that is categorized as Syndromic CMC...
December 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28049430/spread-of-avian-pathogenic-escherichia-coli-st117-o78-h4-in-nordic-broiler-production
#3
Troels Ronco, Marc Stegger, Rikke Heidemann Olsen, Camilla Sekse, Anne Bang Nordstoga, Tarja Pohjanvirta, Berit Lilje, Ulrike Lyhs, Paal Skytt Andersen, Karl Pedersen
BACKGROUND: Escherichia coli infections known as colibacillosis constitute a considerable challenge to poultry farmers worldwide, in terms of decreased animal welfare and production economy. Colibacillosis is caused by avian pathogenic E. coli (APEC). APEC strains are extraintestinal pathogenic E. coli and have in general been characterized as being a genetically diverse population. In the Nordic countries, poultry farmers depend on import of Swedish broiler breeders which are part of a breeding pyramid...
January 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28036006/efficiency-of-emission-control-measures-on-particulate-matter-related-health-impacts-and-economic-cost-during-the-2014-asia-pacific-economic-cooperation-meeting-in-beijing
#4
Qichen Liu, Jing Huang, Bin Guo, Xinbiao Guo
Background: The Asia-Pacific Economic Cooperation (APEC) meeting was held from 5 November to 11 November 2014 in Beijing, and comprehensive emission control measures were implemented. The efficiency of these measures on particulate matter-related health impacts and economic cost need to be evaluated. Methods: The influences of emission control measures during APEC on particulate matter were evaluated, and health economic effects were assessed. Results: Average concentrations of PM2.5 and PM10 during APEC were reduced by 57...
December 28, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28030923/microbiological-characterization-of-vegetables-and-their-rhizosphere-soil-in-eastern-poland
#5
Teresa Kłapeć, Angelina Wójcik-Fatla, Alicja Cholewa, Grażyna Cholewa, Jacek Dutkiewicz
The aim of this study was to investigate the bacteriological quality of 5 kinds of vegetables (lettuce, dill, radish, beetroot, carrot) and their rhizosphere soil, originating from conventional farms located in the Lublin Province of Eastern Poland. A total number of 35 samples of fresh vegetables (FV) taken immediately from soil, 35 samples of soil from rhizosphere of these vegetables (SR) and 35 samples of vegetables sold at retail in the markets in Lublin (VR) were examined. The samples were analysed for the content of: aerobic mesophilic bacteria (AMB) grown at 30°C and 37°C, Gram-negative bacteria of Enterobacteriaceae family, faecal coliform (FC) bacteria, Salmonella spp...
23, 2016: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28012984/virulence-factors-and-antimicrobial-susceptibility-profile-of-extraintestinal-escherichia-coli-isolated-from-an-avian-colisepticemia-outbreak
#6
Jonas Fernandes Maciel, Letícia Beatriz Matter, Michele Martins Trindade, Giovana Camillo, Maristela Lovato, Sônia de Ávila Botton, Agueda Castagna de Vargas
In this study an avian colisepticemia outbreak was investigated. Two isolates from a chicken with colisepticemia were characterized for antimicrobial susceptibility and virulence factors profile. For this purpose 7 antimicrobial and 29 genes (fimH, hrlA/hek, iha, papC, sfa/focCD, tsh, mat, tia, gimB, ibeA, chuA, fyuA, ireA, iroN, irp2, iucD, sitD. chr., sitD. ep., iss, neuC, ompA, traT, astA, hlyA, sat, vat, pic, malX, cvi/cva) were tested. The outbreak happened in a hick chicken breeding located in the northwestern region of Rio Grande do Sul state in South of Brazil and caused 28...
December 21, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27993929/variants-of-asta-gene-among-extra-intestinal-escherichia-coli-of-human-and-avian-origin
#7
Renato Pariz Maluta, Janaína Luisa Leite, Thaís Cabrera Galvão Rojas, Isabel Cristina Affonso Scaletsky, Elisabete Aparecida Lopes Guastalli, Marcelo de Carvalho Ramos, Wanderley Dias da Silveira
Many Escherichia coli strains harbour astA, which is the gene encoding the enteroaggregative E. coli heat-stable enterotoxin (EAST1). This gene is embedded in a putative transposase (ORF1) and presents polymorphism in diarrheagenic strains. Although astA and orf1 are detected in extra-intestinal strains, little is known about polymorphism and differential gene transcription in this pathotype. In the present work, extra-intestinal E. coli from humans (ExPEC) and poultry (APEC) were assayed to verify the presence of astA/orf1 and possible polymorphisms in these genes...
December 18, 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27957331/il-6-specific-autoantibodies-among-apeced-and-thymoma-patients
#8
Jaanika Kärner, Maire Pihlap, Annamari Ranki, Kai Krohn, Katarina Trebusak Podkrajsek, Nina Bratanic, Tadej Battelino, Nick Willcox, Pärt Peterson, Kai Kisand
INTRODUCTION: Both autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and the rare thymoma patients with chronic mucocutaneous candidiasis (CMC) have neutralizing autoantibodies to Th17 cytokines and significant defects in production of IL-22 and IL-17F by their T cells. The cause of these defects is unknown. We hypothesized that they might result from autoimmunity against upstream cytokines normally responsible for generating and maintaining Th17 cells. METHODS: Luciferase immunoprecipitation (LIPS) was used to screen for autoantibodies to IL-6, IL-1β, TGF-β3, IL-21, and IL-23 in patients with APECED or thymoma...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27916941/autoimmune-regulator-expression-in-dc2-4-cells-regulates-the-nf-%C3%AE%C2%BAb-signaling-and-cytokine-expression-of-the-toll-like-receptor-3-pathway
#9
Jitong Sun, Kunwei Niu, Haiying Fu, Haijun Li, Yi Li, Wei Yang
Autoimmune regulator (Aire) mutations result in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), which manifests as multi-organ autoimmunity and chronic mucocutaneous candidiasis (CMC). Indendritic cells (DCs), pattern recognition receptors (PRR), such as Toll-like receptors (TLRs), are closely involved in the recognition of various pathogens, activating the intercellular signaling pathway, followed by the activation of transcription factors and the expression of downstream genes, which take part in mediating the immune response and maintaining immune tolerance...
December 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27889086/impacts-of-regional-transport-on-black-carbon-in-huairou-beijing-china
#10
Yuqin Wang, Benjamin de Foy, James J Schauer, Michael R Olson, Yang Zhang, Zhengqiang Li, Yuanxun Zhang
The 22(nd) Asia-Pacific Economic Cooperation (APEC) Conference was held near Yanqi Lake, Huairou, in Beijing, China during November 10-11, 2014. To guarantee haze-free days during the APEC Conference, the Beijing government and the governments of the surrounding provinces implemented a series of controls. Three months of Aethalometer 880 nm black carbon (BC) measurements were examined to understand the hourly fluctuations in BC concentrations that resulted from emission controls and meteorology changes. Measurements were collected at the University of Chinese Academy of Sciences near the APEC Conference site and in Central Beijing at the Institute of Remote Sensing and Digital Earth of the Chinese Academy of Sciences...
February 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27887603/genetic-elements-associated-with-antimicrobial-resistance-among-avian-pathogenic-escherichia-coli
#11
Amal Awad, Nagah Arafat, Mohamed Elhadidy
BACKGROUND: Avian-pathogenic Escherichia coli (APEC) are pathogenic strains of E. coli that are responsible for one of the most predominant bacterial disease affecting poultry worldwide called avian colibacillosis. This study describes the genetic determinants implicated in antimicrobial resistance among APEC isolated from different broiler farms in Egypt. METHODS: A total of 116 APEC were investigated by serotyping, antimicrobial resistance patterns to 10 antimicrobials, and the genetic mechanisms underlying the antimicrobial-resistant phenotypes...
November 25, 2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27875980/comparative-genomics-of-european-avian-pathogenic-e-coli-apec
#12
Guido Cordoni, Martin J Woodward, Huihai Wu, Mishaal Alanazi, Tim Wallis, Roberto M La Ragione
BACKGROUND: Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which results in significant economic losses to the poultry industry worldwide. However, the diversity between isolates remains poorly understood. Here, a total of 272 APEC isolates collected from the United Kingdom (UK), Italy and Germany were characterised using multiplex polymerase chain reactions (PCRs) targeting 22 equally weighted factors covering virulence genes, R-type and phylogroup. Following these analysis, 95 of the selected strains were further analysed using Whole Genome Sequencing (WGS)...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27811098/complete-genome-sequence-of-the-avian-pathogenic-escherichia-coli-strain-apec-o18
#13
Bryon A Nicholson, Yvonne M Wannemuehler, Catherine M Logue, Ganwu Li, Lisa K Nolan
Avian-pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis, a disease that affects all facets of poultry production worldwide, resulting in multimillion dollar losses annually. Here, we report the genome sequence of an APEC O18 sequence type 95 (ST95) strain associated with disease in a chicken.
November 3, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27810213/comparison-between-avian-pathogenic-apec-and-avian-faecal-afec-escherichia-coli-isolated-from-different-regions-in-brazil
#14
F Silveira, R P Maluta, M R Tiba, J B de Paiva, E A L Guastalli, W D da Silveira
Detection and analysis of virulence-associated genes (VAGs) of avian pathogenic Escherichia coli (APEC) may be helpful to distinguish pathogenic from commensal faecal strains (AFEC). The aim of this study was to characterise 120 isolates of avian Escherichia coli, comprising 91 APEC (from diseased birds) and 29 AFEC (from healthy chickens), collected in Brazil. Phylogenetic analysis and in vivo pathogenicity testing was performed on 38 VAGs. The VAGs iucD, iutA, iroN, fepC, ompT, cvi and hlyF were statistically associated with medium and high pathogenicity (MP/HP) strains...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27795362/novel-microrna-involved-in-host-response-to-avian-pathogenic-escherichia-coli-identified-by-deep-sequencing-and-integration-analysis
#15
Xinzheng Jia, Qinghua Nie, Xiquan Zhang, Lisa K Nolan, Susan J Lamont
Avian pathogenic Escherichia coli (APEC) causes one of the most common bacterial diseases of poultry worldwide. Effective control methods are therefore desirable and will be facilitated by a better understanding of the host response to the pathogen. Currently, microRNAs (miRNAs) involved in host resistance to APEC are unknown. Here, we applied RNA sequencing to explore the changed miRNAs and deregulated genes in the spleen of three groups of broilers: nonchallenged (NC), APEC-challenged with mild pathology (CM), and APEC-challenged with severe pathology (CS)...
January 2017: Infection and Immunity
https://www.readbyqxmd.com/read/27789334/clustered-regularly-interspaced-short-palindromic-repeat-crispr-diversity-and-virulence-factor-distribution-in-avian-escherichia-coli
#16
Qiang Fu, Zhixin Su, Yuqiang Cheng, Zhaofei Wang, Shiyu Li, Heng'an Wang, Jianhe Sun, Yaxian Yan
In order to investigate the diverse characteristics of clustered, regularly interspaced short palindromic repeat (CRISPR) arrays and the distribution of virulence factor genes in avian Escherichia coli, 80 E.coli isolates obtained from chickens with avian pathogenic E.coli (APEC) or avian fecal commensal E. coli (AFEC) were identified. Using the multiplex polymerase chain reaction (PCR), five genes were subjected to phylogenetic typing and examined for CRISPR arrays to study genetic relatedness among the strains...
October 24, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27780749/efficacy-tolerability-and-biomarker-analyses-of-once-every-2-weeks-cetuximab-plus-first-line-folfox-or-folfiri-in-patients-with-kras-or-all-ras-wild-type-metastatic-colorectal-cancer-the-phase-2-apec-study
#17
Ann-Lii Cheng, Gerardo Cornelio, Lin Shen, Timothy Price, Tsai-Sheng Yang, Ik Joo Chung, Guang-Hai Dai, Jen-Kou Lin, Atul Sharma, Kun-Huei Yeh, Brigette Ma, Adel Zaatar, Zhongzhen Guan, Nehal Masood, Vichien Srimuninnimit, Thomas Yau, Peter Gibbs, Xiuwen Wang, Dinesh Chandra Doval, Seung-Taek Oh, Byoung Yong Shim, Charity Gorospe, Hwei-Ming Wang, Ekaphop Sirachainan, Andrew Hill, Kwang Wook Suh, Frank Beier, Sudipto Chatterjee, Robert Lim
BACKGROUND: In patients with KRAS wild-type (wt) metastatic colorectal cancer (mCRC), outcomes with first-line chemotherapies are improved by adding weekly cetuximab. The APEC study investigated first-line once-every-2-weeks cetuximab plus chemotherapy for patients with KRAS wt mCRC; additional biomarker subgroups were also analyzed. PATIENTS AND METHODS: APEC was a nonrandomized phase 2 trial conducted in the Asia-Pacific region. Patients (n = 289) received once-every-2-weeks cetuximab with investigator's choice of chemotherapy (FOLFOX or FOLFIRI)...
September 7, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27738580/apec-business-ethics-for-smes-forum
#18
Masami Ishii
No abstract text is available yet for this article.
July 2016: Japan Medical Association Journal: JMAJ
https://www.readbyqxmd.com/read/27702916/evaluation-of-the-efficacy-of-chitosan-nanoparticles-loaded-%C3%AE-kaz14-bacteriophage-in-the-biological-control-of-colibacillosis-in-chickens
#19
A A Kaikabo, S M AbdulKarim, F Abas
Disease inflicted by avian pathogenic Escherichia coli (APEC) causes economic losses and burden to the poultry industry worldwide. In this study, the efficacy of chitosan nanoparticles loaded ΦKAZ14 (C-ΦKAZ14 NPs) as an oral biological therapy for Colibacillosis was evaluated. C-ΦKAZ14 NPs containing 10(7) PFU/ml of ΦKAZ14 (Myoviridae; T4-like coliphage) bacteriophage were used to treat experimentally APEC-infected COBB 500 broiler chicks. C-ΦKAZ14 NPs and ΦKAZ14 bacteriophage were administered orally in a single dose...
October 4, 2016: Poultry Science
https://www.readbyqxmd.com/read/27688120/characterisation-of-a-new-highly-effective-method-for-detecting-nematode-eggs-ascaris-spp-toxocara-spp-trichuris-spp-in-sewage-sludge-containing-flocculants
#20
Jolanta Zdybel, Jacek Karamon, Mirosław Różycki, Ewa Bilska-Zając, Teresa Kłapeć, Tomasz Cencek
Because traditional methods used for sewage sludge parasitological examinations have low sensitivity, a new, highly effective method (own method - OM) was devised. The principle of this method is to eliminate the flocculent effect on the structure of sewage sludge by mechanically damaging floccules in the presence of surfactants and to increase the effectiveness of egg isolation processes in large volumes of liquids. The objective of this study was to estimate the effectiveness of the OM in detecting nematode eggs in sewage sludge samples containing flocculants...
November 2016: Experimental Parasitology
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