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https://www.readbyqxmd.com/read/27889086/impacts-of-regional-transport-on-black-carbon-in-huairou-beijing-china
#1
Yuqin Wang, Benjamin de Foy, James J Schauer, Michael R Olson, Yang Zhang, Zhengqiang Li, Yuanxun Zhang
The 22(nd) Asia-Pacific Economic Cooperation (APEC) Conference was held near Yanqi Lake, Huairou, in Beijing, China during November 10-11, 2014. To guarantee haze-free days during the APEC Conference, the Beijing government and the governments of the surrounding provinces implemented a series of controls. Three months of Aethalometer 880 nm black carbon (BC) measurements were examined to understand the hourly fluctuations in BC concentrations that resulted from emission controls and meteorology changes. Measurements were collected at the University of Chinese Academy of Sciences near the APEC Conference site and in Central Beijing at the Institute of Remote Sensing and Digital Earth of the Chinese Academy of Sciences...
November 23, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27887603/genetic-elements-associated-with-antimicrobial-resistance-among-avian-pathogenic-escherichia-coli
#2
Amal Awad, Nagah Arafat, Mohamed Elhadidy
BACKGROUND: Avian-pathogenic Escherichia coli (APEC) are pathogenic strains of E. coli that are responsible for one of the most predominant bacterial disease affecting poultry worldwide called avian colibacillosis. This study describes the genetic determinants implicated in antimicrobial resistance among APEC isolated from different broiler farms in Egypt. METHODS: A total of 116 APEC were investigated by serotyping, antimicrobial resistance patterns to 10 antimicrobials, and the genetic mechanisms underlying the antimicrobial-resistant phenotypes...
November 25, 2016: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/27875980/comparative-genomics-of-european-avian-pathogenic-e-coli-apec
#3
Guido Cordoni, Martin J Woodward, Huihai Wu, Mishaal Alanazi, Tim Wallis, Roberto M La Ragione
BACKGROUND: Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which results in significant economic losses to the poultry industry worldwide. However, the diversity between isolates remains poorly understood. Here, a total of 272 APEC isolates collected from the United Kingdom (UK), Italy and Germany were characterised using multiplex polymerase chain reactions (PCRs) targeting 22 equally weighted factors covering virulence genes, R-type and phylogroup. Following these analysis, 95 of the selected strains were further analysed using Whole Genome Sequencing (WGS)...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27811098/complete-genome-sequence-of-the-avian-pathogenic-escherichia-coli-strain-apec-o18
#4
Bryon A Nicholson, Yvonne M Wannemuehler, Catherine M Logue, Ganwu Li, Lisa K Nolan
Avian-pathogenic Escherichia coli (APEC) is the causative agent of colibacillosis, a disease that affects all facets of poultry production worldwide, resulting in multimillion dollar losses annually. Here, we report the genome sequence of an APEC O18 sequence type 95 (ST95) strain associated with disease in a chicken.
November 3, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27810213/comparison-between-avian-pathogenic-apec-and-avian-faecal-afec-escherichia-coli-isolated-from-different-regions-in-brazil
#5
F Silveira, R P Maluta, M R Tiba, J B de Paiva, E A L Guastalli, W D da Silveira
Detection and analysis of virulence-associated genes (VAGs) of avian pathogenic Escherichia coli (APEC) may be helpful to distinguish pathogenic from commensal faecal strains (AFEC). The aim of this study was to characterise 120 isolates of avian Escherichia coli, comprising 91 APEC (from diseased birds) and 29 AFEC (from healthy chickens), collected in Brazil. Phylogenetic analysis and in vivo pathogenicity testing was performed on 38 VAGs. The VAGs iucD, iutA, iroN, fepC, ompT, cvi and hlyF were statistically associated with medium and high pathogenicity (MP/HP) strains...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27795362/novel-mirna-involved-in-host-response-to-avian-pathogenic-escherichia-coli-identified-by-deep-sequencing-and-integration-analysis
#6
Xinzheng Jia, Qinghua Nie, Xiquan Zhang, Lisa K Nolan, Susan J Lamont
Avian pathogenic Escherichia coli (APEC) causes one of the most common bacterial diseases of poultry worldwide. Effective control methods are, therefore, desirable and will be facilitated by a better understanding of the host response to the pathogen. Currently, miRNAs involved in host resistance to APEC are unknown. Here, we applied RNA sequencing to explore the changed miRNAs and deregulated genes in the spleen of broilers from non-challenged (NC), APEC challenged-mild pathology (CM), and APEC challenged-severe pathology (CS) groups...
October 17, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27789334/clustered-regularly-interspaced-short-palindromic-repeat-crispr-diversity-and-virulence-factor-distribution-in-avian-escherichia-coli
#7
Qiang Fu, Zhixin Su, Yuqiang Cheng, Zhaofei Wang, Shiyu Li, Heng'an Wang, Jianhe Sun, Yaxian Yan
In order to investigate the diverse characteristics of clustered, regularly interspaced short palindromic repeat (CRISPR) arrays and the distribution of virulence factor genes in avian Escherichia coli, 80 E.coli isolates obtained from chickens with avian pathogenic E.coli (APEC) or avian fecal commensal E. coli (AFEC) were identified. Using the multiplex polymerase chain reaction (PCR), five genes were subjected to phylogenetic typing and examined for CRISPR arrays to study genetic relatedness among the strains...
October 24, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27780749/efficacy-tolerability-and-biomarker-analyses-of-once-every-2-weeks-cetuximab-plus-first-line-folfox-or-folfiri-in-patients-with-kras-or-all-ras-wild-type-metastatic-colorectal-cancer-the-phase-2-apec-study
#8
Ann-Lii Cheng, Gerardo Cornelio, Lin Shen, Timothy Price, Tsai-Sheng Yang, Ik Joo Chung, Guang-Hai Dai, Jen-Kou Lin, Atul Sharma, Kun-Huei Yeh, Brigette Ma, Adel Zaatar, Zhongzhen Guan, Nehal Masood, Vichien Srimuninnimit, Thomas Yau, Peter Gibbs, Xiuwen Wang, Dinesh Chandra Doval, Seung-Taek Oh, Byoung Yong Shim, Charity Gorospe, Hwei-Ming Wang, Ekaphop Sirachainan, Andrew Hill, Kwang Wook Suh, Frank Beier, Sudipto Chatterjee, Robert Lim
BACKGROUND: In patients with KRAS wild-type (wt) metastatic colorectal cancer (mCRC), outcomes with first-line chemotherapies are improved by adding weekly cetuximab. The APEC study investigated first-line once-every-2-weeks cetuximab plus chemotherapy for patients with KRAS wt mCRC; additional biomarker subgroups were also analyzed. PATIENTS AND METHODS: APEC was a nonrandomized phase 2 trial conducted in the Asia-Pacific region. Patients (n = 289) received once-every-2-weeks cetuximab with investigator's choice of chemotherapy (FOLFOX or FOLFIRI)...
September 7, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27738580/apec-business-ethics-for-smes-forum
#9
Masami Ishii
No abstract text is available yet for this article.
July 2016: Japan Medical Association Journal: JMAJ
https://www.readbyqxmd.com/read/27702916/evaluation-of-the-efficacy-of-chitosan-nanoparticles-loaded-%C3%AE-kaz14-bacteriophage-in-the-biological-control-of-colibacillosis-in-chickens
#10
A A Kaikabo, S M AbdulKarim, F Abas
Disease inflicted by avian pathogenic Escherichia coli (APEC) causes economic losses and burden to the poultry industry worldwide. In this study, the efficacy of chitosan nanoparticles loaded ΦKAZ14 (C-ΦKAZ14 NPs) as an oral biological therapy for Colibacillosis was evaluated. C-ΦKAZ14 NPs containing 10(7) PFU/ml of ΦKAZ14 (Myoviridae; T4-like coliphage) bacteriophage were used to treat experimentally APEC-infected COBB 500 broiler chicks. C-ΦKAZ14 NPs and ΦKAZ14 bacteriophage were administered orally in a single dose...
October 4, 2016: Poultry Science
https://www.readbyqxmd.com/read/27688120/characterisation-of-a-new-highly-effective-method-for-detecting-nematode-eggs-ascaris-spp-toxocara-spp-trichuris-spp-in-sewage-sludge-containing-flocculants
#11
Jolanta Zdybel, Jacek Karamon, Mirosław Różycki, Ewa Bilska-Zając, Teresa Kłapeć, Tomasz Cencek
Because traditional methods used for sewage sludge parasitological examinations have low sensitivity, a new, highly effective method (own method - OM) was devised. The principle of this method is to eliminate the flocculent effect on the structure of sewage sludge by mechanically damaging floccules in the presence of surfactants and to increase the effectiveness of egg isolation processes in large volumes of liquids. The objective of this study was to estimate the effectiveness of the OM in detecting nematode eggs in sewage sludge samples containing flocculants...
September 28, 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/27687932/bioluminescent-avian-pathogenic-escherichia-coli-for-monitoring-colibacillosis-in-experimentally-infected-chickens
#12
Leon H Oosterik, Huruma N Tuntufye, Jessica Tsonos, Tom Luyten, Sam Noppen, Sandra Liekens, Rob Lavigne, Patrick Butaye, Bruno M Goddeeris
Avian pathogenic Escherichia coli (APEC) are responsible for significant economic losses in the poultry industry. In this study, a model for investigating the pathogenesis of APEC infections was established. APEC strain CH2 (O78) was marked with the luciferase operon (luxCDABE) using a Tn7 transposon and tissues of experimentally infected chickens were analysed for a correlation between the bioluminescent signal and the number of bacteria. Transposition of the lux operon into the chromosome of the APEC isolate did not affect sensitivity to lytic bacteriophages and there was no effect on virulence in an intratracheal infection model in 1-day-old chicks, although results with a subcutaneous infection model were inconclusive...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27682444/%C3%AE-defensin-cnv-is-not-associated-with-susceptibility-to-c-albicans-infections-in-sardinian-aps-i-patients
#13
Federica Incani, Carla Cossu, Alessandra Meloni, Valeria Faà, Maria Luisa Serra, Federico Dettori, Antonella Meloni, Maria Cristina Rosatelli
OBJECTIVE: he aim of this study was to investigate whether a variation in the genomic copy number (CNV) of the β-defensin cluster could be associated with the predisposition to Chronic Mucocutaneous Candidiasis (CMC) in Sardinian APECED patients. SUBJECTS AND METHODS: The β-defensin copy number variation was determined by MLPA analysis in 18 Sardinian APECED patients with CMC and in 21 Sardinian controls. Statistical analyses were performed with ANOVA-one way test...
September 28, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27680499/a-paradox-for-air-pollution-controlling-in-china-revealed-by-apec-blue-and-parade-blue
#14
Haoran Liu, Cheng Liu, Zhouqing Xie, Ying Li, Xin Huang, Shanshan Wang, Jin Xu, Pinhua Xie
A series of strict emission control measures were implemented in Beijing and surrounding regions to ensure good air quality during the 2014 Asia-Pacific Economic Cooperation (APEC) summit and 2015 Grand Military Parade (Parade), which led to blue sky days during these two events commonly referred to as "APEC Blue" and "Parade Blue". Here we calculated Multi-Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) and Ozone Monitoring Instrument (OMI) NO2 and HCHO results based on well known DOAS trace gas fitting algorithm and WRF-Chem model (with measured climatology parameter and newest emission inventor) simulated trace gases profiles...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27650964/mortality-benefits-of-vigorous-air-quality-improvement-interventions-during-the-periods-of-apec-blue-and-parade-blue-in-beijing-china
#15
Hualiang Lin, Tao Liu, Fang Fang, Jianpeng Xiao, Weilin Zeng, Xing Li, Lingchuan Guo, Linwei Tian, Mario Schootman, Katherine A Stamatakis, Zhengmin Qian, Wenjun Ma
Vigorous air pollution control measures were implemented during the 2014 Asia-Pacific Economic Cooperation and a large-scale military parade (described here as "APEC Blue" and "Parade Blue" periods) in Beijing, China. A natural experiment was conducted in a health impact assessment framework to estimate the number of deaths attributable to PM2.5, using concentration-response functions derived from previous studies conducted in Beijing, combined with the differences in PM2.5 concentrations between intervention and reference periods...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27630634/escherichia-coli-type-iii-secretion-system-2-atpase-eivc-is-involved-in-the-motility-and-virulence-of-avian-pathogenic-escherichia-coli
#16
Shaohui Wang, Xin Liu, Xuan Xu, Denghui Yang, Dong Wang, Xiangan Han, Yonghong Shi, Mingxing Tian, Chan Ding, Daxin Peng, Shengqing Yu
Type III secretion systems (T3SSs) are crucial for bacterial infections because they deliver effector proteins into host cells. The Escherichia coli type III secretion system 2 (ETT2) is present in the majority of E. coli strains, and although it is degenerate, ETT2 regulates bacterial virulence. An ATPase is essential for T3SS secretion, but the function of the ETT2 ATPase has not been demonstrated. Here, we show that EivC is homologous to the β subunit of F0F1 ATPases and it possesses ATPase activity. To investigate the effects of ETT2 ATPase EivC on the phenotype and virulence of avian pathogenic Escherichia coli (APEC), eivC mutant and complemented strains were constructed and characterized...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27622939/altered-b-cell-homeostasis-and-toll-like-receptor-9-driven-response-in-patients-affected-by-autoimmune-polyglandular-syndrome-type-1-altered-b-cell-phenotype-and-dysregulation-of-the-b-cell-function-in-apeced-patients
#17
Valentina Perri, Elena Gianchecchi, Riccardo Scarpa, Mariella Valenzise, Maria Manuela Rosado, Ezio Giorda, Antonino Crinò, Marco Cappa, Susi Barollo, Silvia Garelli, Corrado Betterle, Alessandra Fierabracci
APECED is a T-cell mediated disease with increased frequencies of CD8+ effector and reduction of FoxP3+ T regulatory cells. Antibodies against affected organs and neutralizing to cytokines are found in the peripheral blood. The contribution of B cells to multiorgan autoimmunity in Aire-/- mice was reported opening perspectives on the utility of anti-B cell therapy. We aimed to analyse the B cell phenotype of APECED patients compared to age-matched controls. FACS analysis was conducted on PBMC in basal conditions and following CpG stimulation...
September 9, 2016: Immunobiology
https://www.readbyqxmd.com/read/27616446/the-yfco-fimbriae-gene-enhances-adherence-and-colonization-abilities-of-avian-pathogenic-escherichia-coli-in%C3%A2-vivo-and-in%C3%A2-vitro
#18
Yaxin Li, Haojin Wang, Jianluan Ren, Ling Chen, Xiangkai Zhuge, Lin Hu, Dezhi Li, Fang Tang, Jianjun Dai
Chaperone-usher (CU) fimbriae, which are adhesive surface organelles found in many Gram-negative bacteria, mediate tissue tropism through the interaction of fimbrial adhesins with specific receptors expressed on the host cell surface. A CU fimbrial gene yfcO, was identified in avian pathogenic E. coli (APEC) strain DE205B via gene functional analysis. In this study, yfcO was found in 13.41% (11/82) of E. coli strains, including phylogenetic groups A, B1, B2 and D, with the highest percentage in group B2. The expression of yfcO in biofilm forming bacteria was significantly higher (P < 0...
September 9, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27597936/novel-findings-into-aire-genetics-and-functioning-clinical-implications
#19
REVIEW
Lucia De Martino, Donatella Capalbo, Nicola Improda, Paola Lorello, Carla Ungaro, Raffaella Di Mase, Emilia Cirillo, Claudio Pignata, Mariacarolina Salerno
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), formerly known as autoimmune polyendocrine syndrome type 1, is a paradigm of a monogenic autoimmune disease caused by mutations of a gene, named autoimmune regulator (AIRE). AIRE acts as a transcription regulator that promotes immunological central tolerance by inducing the ectopic thymic expression of many tissue-specific antigens. Although the syndrome is a monogenic disease, it is characterized by a wide variability of the clinical expression with no significant correlation between genotype and phenotype...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27588307/redefined-clinical-features-and-diagnostic-criteria-in-autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy
#20
Elise M N Ferre, Stacey R Rose, Sergio D Rosenzweig, Peter D Burbelo, Kimberly R Romito, Julie E Niemela, Lindsey B Rosen, Timothy J Break, Wenjuan Gu, Sally Hunsberger, Sarah K Browne, Amy P Hsu, Shakuntala Rampertaap, Muthulekha Swamydas, Amanda L Collar, Heidi H Kong, Chyi-Chia Richard Lee, David Chascsa, Thomas Simcox, Angela Pham, Anamaria Bondici, Mukil Natarajan, Joseph Monsale, David E Kleiner, Martha Quezado, Ilias Alevizos, Niki M Moutsopoulos, Lynne Yockey, Cathleen Frein, Ariane Soldatos, Katherine R Calvo, Jennifer Adjemian, Morgan N Similuk, David M Lang, Kelly D Stone, Gulbu Uzel, Jeffrey B Kopp, Rachel J Bishop, Steven M Holland, Kenneth N Olivier, Thomas A Fleisher, Theo Heller, Karen K Winer, Michail S Lionakis
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare primary immunodeficiency disorder typically caused by homozygous AIRE mutations. It classically presents with chronic mucocutaneous candidiasis and autoimmunity that primarily targets endocrine tissues; hypoparathyroidism and adrenal insufficiency are most common. Developing any two of these classic triad manifestations establishes the diagnosis. Although widely recognized in Europe, where nonendocrine autoimmune manifestations are uncommon, APECED is less defined in patients from the Western Hemisphere...
August 18, 2016: JCI Insight
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