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Manita Subedi, Rebanta Kumar Bhattarai, Bhuminand Devkota, Sarita Phuyal, Himal Luitel
The original article [1] contains errors in author panels and their contributions, errors in both the Methodology and the Results sections, and errors with respect to funding sources. The affected sections of the manuscript and their respective regions of corrected text can be viewed ahead.
May 22, 2018: BMC Veterinary Research
Dezhi Li, Fang Tang, Feng Xue, Jianluan Ren, Yun Liu, Dehong Yang, Jianjun Dai
Bacterial acquisition of prophages reflects natural selection. Phage DNA has been shown to constitute up to 20% if bacterial genomes. However, prophages' role in Avian Pathogenic Escherichia coli (APEC) is unclear. In this study, APEC strain DE142 harboring prophage phiv142-3, was subjected to deletion and the WT and deletion mutant were characterized under a range of conditions. Prophage deletion mutant DE142Δphiv142-3 was constructed and characterized. The DE142Δphiv142-3 colonies were much smaller than those of the wild-type, and the mutant cells were elongated...
May 2018: Veterinary Microbiology
Yangzhi Mo, Jun Li, Bin Jiang, Tao Su, Xiaofei Geng, Junwen Liu, Haoyu Jiang, Chengde Shen, Ping Ding, Guangcai Zhong, Zhineng Cheng, Yuhong Liao, Chongguo Tian, Yingjun Chen, Gan Zhang
Humic-like substances (HULIS) are a class of high molecular weight, light-absorbing compounds that are highly related to brown carbon (BrC). In this study, the sources and compositions of HULIS isolated from fine particles collected in Beijing, China during the 2014 Asia-Pacific Economic Cooperation (APEC) summit were characterized based on carbon isotope (13 C and 14 C) and Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS) analyses, respectively. HULIS were the main light-absorbing components of water-soluble organic carbon (WSOC), accounting for 80...
April 16, 2018: Environmental Pollution
Jose Antonio Tavares de Albuquerque, Pinaki Prosad Banerjee, Angela Castoldi, Royce Ma, Nuria Bengala Zurro, Leandro Hideki Ynoue, Christina Arslanian, Marina Uchoa Wall Barbosa-Carvalho, Joya Emilie de Menezes Correia-Deur, Fernanda Guimarães Weiler, Magnus Regios Dias-da-Silva, Marise Lazaretti-Castro, Luis Alberto Pedroza, Niels Olsen Saraiva Câmara, Emily Mace, Jordan Scott Orange, Antonio Condino-Neto
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene ( AIRE ). Patients with AIRE mutations are susceptible to Candida albicans infection and present with autoimmune disorders. We previously demonstrated that cytoplasmic AIRE regulates the Syk-dependent Dectin-1 pathway. In this study, we further evaluated direct contact with fungal elements, synapse formation, and the response of macrophage-like THP-1 cells to C...
2018: Frontiers in Immunology
Sanjay Miglani, Hyeon-Cheol Henry Kim
No abstract text is available yet for this article.
April 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
Lu-Yuan Peng, Meng Yuan, Zhen-Qiang Cui, Zong-Mei Wu, Zhen-Jiang Yu, Ke Song, Bo Tang, Ben-Dong Fu
The study aimed to investigate whether rutin affects the quorum sensing (QS) of avian pathogenic Escherichia coli (APEC). In this study, APEC-O78 was selected as the test strain. We mainly examined the effects of rutin on the AI-2 secretion by bioluminescence assay, biofilm formation through a crystal violet staining method, and expression of virulence genes of APEC by qRT-PCR. We found that rutin can significantly interfering with QS through reducing the secretion of AI-2, inhibited the biofilm formation, and reduced the expression of virulence genes of APEC...
April 5, 2018: Microbial Pathogenesis
Sajid Umar, Ana Triana Maiyah, Mehwish Shareef, Hajra Qadir, Qamarun Nisa, Seema Abbas
Antibiotic resistance in avian pathogenic Escherichia coli (APEC) is a common problem in the Indonesian poultry industry. Zoo birds have been postulated as sentinels, reservoirs, and potential spreaders of antibiotic resistance, although much is still unknown about the strains of zoo birds. Disinfection can reduce the infection burden. However, little is known about the presence of resistance against these products. Sixty one APEC strains were isolated from Indonesian zoo birds. The resistance to different classes of antibiotics as well as the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of five disinfectants most often used in the poultry industry was determined...
March 2018: Pakistan Journal of Pharmaceutical Sciences
Qingqing Yu, Weiqiang Yang, Ming Zhu, Bo Gao, Sheng Li, Guanghui Li, Hua Fang, Huaishan Zhou, Huina Zhang, Zhenfeng Wu, Wei Song, Jihua Tan, Yanli Zhang, Xinhui Bi, Laiguo Chen, Xinming Wang
For human health benefits it is crucial to see if carcinogenic air pollutants like polycyclic aromatic hydrocarbons (PAHs) are reduced accordingly along with the control of the criteria pollutants including fine particles (PM2.5 ). A number of studies documented that enhanced temporary emission control during the 2014 Asia-Pacific Economic Cooperation summit (APEC) in Beijing resulted in substantial drops of observed ambient PM2.5 , as well as PAHs, in urban areas of Beijing, yet it is not clear whether PM2...
March 29, 2018: Environmental Pollution
Jiale Ma, Min Sun, Zihao Pan, Wenchao Song, Chengping Lu, Huochun Yao
Type VI secretion systems (T6SSs) contribute to the pathogenicity of avian pathogenic Escherichia coli (APEC), one of the leading causative agents of sepsis and meningitis in poultry. The Hcp protein is a core component of the T6SS tail tube and acts as an exported receptor and a chaperone of effectors. In this study, four distinct Hcp types (Ia, Ib, IIa, and IIb) were designated in Gram-negative bacteria, three of which were widely distributed in APEC. We detected divergence in transcription levels among three hcp clusters in 50% duck serum and demonstrated that hcp1 was upregulated by relieving Fur repression...
March 29, 2018: Emerging Microbes & Infections
Manita Subedi, Himal Luitel, Bhuminanda Devkota, Rebanta Kumar Bhattarai, Sarita Phuyal, Prabhat Panthi, Anil Shrestha, Dhiraj Kumar Chaudhary
BACKGROUND: Avian pathogenic Escherichia coli (APEC) are causative agent of extraintestinal infections, collectively known as colibacillosis, which results significant losses in poultry industries. The extraintestinal survival of E. coli is facilitated by numerous virulence factors which are coded by virulence genes. This study was conducted to find out the pattern of antibiotic resistance and virulence genes content in the APEC strains isolated from broiler chickens at National Avian Disease Investigation Laboratory and Veterinary Teaching Hospital, Rampur, Chitwan, Nepal...
March 27, 2018: BMC Veterinary Research
Hakimeh Ebrahimi-Nik, Mohammad Reza Bassami, Mehrdad Mohri, Mehrnaz Rad, Mazhar I Khan
Avian Colibacillosis is among the major causes of economic loss in the poultry industry worldwide, with a more vivid impact on developing countries. The involvement of several bacteria has made it challenging to develop effective vaccines for this disease, particularly because it is notoriously difficult to make a vaccine that contains all the contributing pathogenic bacteria. Here, we report the design and fabrication of a bacterial ghost (BG) of E. coli O78:K80, which is among the major bacterial serotypes responsible for this disease...
2018: PloS One
Feng Zhu, Yinling Hu
A pathogenic connection between autoreactive T cells, fungal infection, and carcinogenesis has been demonstrated in studies of human autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) as well as in a mouse model in which kinase-dead Ikkα knock-in mice develop impaired central tolerance, autoreactive T cell-mediated autoimmunity, chronic fungal infection, and esophageal squamous cell carcinoma, which recapitulates APECED. IκB kinase α (IKKα) is one subunit of the IKK complex required for NF-κB activation...
April 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Priscila Regina Guerra, Ana Herrero-Fresno, Susanne Elisabeth Pors, Shahana Ahmed, Dan Wang, Ida Thøfner, Fabio Antenucci, John Elmerdahl Olsen
Over the last few years, polyamines have been described as key-signal of virulence in pathogenic bacteria. In the current study, we investigated whether the knockout of genes related to polyamine biosynthesis and putrescine transport affected the virulence of an avian pathogenic E. coli (APEC) strain. One-week-old White Leghorn chickens were infected intratracheally with mutants in polyamine biosynthesis (ΔspeB/C and ΔspeD/E) and transport genes (ΔpotE) of a well-characterized APEC strain of ST117 (O83: H4)...
March 2018: Veterinary Microbiology
Xiangjun Song, Chunxiao Li, Kezong Qi, Jian Tu, Hongmei Liu, Ting Xue
Avian pathogenic Escherichia coli (APEC) are important pathogens that cause serious economic losses to the poultry industry worldwide. The PhoP/Q system is essential for APEC pathogenicity, and its mutation leads to a decrease in ybjX gene expression, but whether ybjX regulated by PhoP/Q plays a role in pathogenicity remains unclear. The role of ybjX in APEC pathogenicity was investigated using a ybjX mutant strain constructed from APEC strain AE17 by the Red recombination method. The mutant strain displayed significantly reduced adherence to and invasion of chicken embryo fibroblast cell line (DF-1) cells...
June 2018: Avian Pathology: Journal of the W.V.P.A
Nianliang Cheng, Ziyue Chen, Feng Sun, Ruiwen Sun, Xin Dong, Xiaoming Xie, Chunxue Xu
Based on ozone observation data from urban stations and the Dingling (DL) background station, we investigated the trend of ozone concentrations in Beijing during 2004-2015. For urban stations, both O3 _1 h and O3 _8 h increased stably with a clear and significant linear pattern and the increase rate was notably higher during the period of May to Sep. Meanwhile, the variation of O3 _1 h and O3 _8 h for the DL station did not demonstrate a regular pattern. During this period, the differences between the diurnal peak of ozone concentrations at the DL background station and urban stations decreased significantly due to the rapid urbanization of Beijing...
June 2018: Environmental Pollution
Sun-Ting Ma, Guo-Jie Ding, Xue-Wei Huang, Zi-Wei Wang, Li Wang, Mei-Ling Yu, Wen Shi, Yan-Ping Jiang, Li-Jie Tang, Yi-Gang Xu, Yi-Jing Li
PURPOSE: Avian colibacillosis is responsible for economic losses to poultry producers worldwide. To combat this, we aimed to develop an effective oral vaccine for chicken against O78 avian pathogenic Escherichia coli (APEC) infection through a Lactobacillus delivery system. METHODOLOGY: Eight Lactobacillus strains isolated from the intestines of broiler chickens were evaluated based on their in vitro adherence ability to assess their potential as a delivery vector...
March 2018: Journal of Medical Microbiology
Erica Sanford, Kelly Watkins, Shareef Nahas, Michael Gottschalk, Nicole Coufal, Lauge Farnaes, David Dimmock, Stephen Kingsmore, Rcigm Investigators
Autoimmune polyendocrine syndrome type 1 (APS1; OMIM #240300), also referred to as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is a rare monogenic disorder caused by mutations in the autoimmune regulator (AIRE) gene. APS1 is classically characterized by a triad of chronic mucocutaneous candidiasis, autoimmune hypoparathyroidism, and autoimmune adrenocortical insufficiency. We report a five-year-old female who presented with symptoms of tetany due to hypocalcemia and was subsequently found to be secondary to hypoparathyroidism...
February 1, 2018: Cold Spring Harbor Molecular Case Studies
Giuseppina Conteduca, Francesco Indiveri, Gilberto Filaci, Simone Negrini
The autoimmune regulator gene (AIRE) is a transcription factor expressed both in the thymus, by medullary thymic epithelial cells, and in secondary lymphoid organs. AIRE controls the local transcription of organ- specific proteins typically expressed in peripheral tissues, thus allowing the negative selection of self- reactive T cells. The crucial role played by AIRE in central immune tolerance emerged in the studies on the pathogenesis of Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy, a rare inherited polyendocrine/autoimmune disease...
April 2018: Autoimmunity Reviews
Lumin Yu, Wenchang Li, Ming Zhang, Yunmei Cui, Xiaolin Chen, Jingtian Ni, Li Yu, Fei Shang, Ting Xue
Avian pathogenic Escherichia coli (APEC) causes airsacculitis, polyserositis, septicemia, and other mainly extraintestinal diseases in chickens, ducks, geese, pigeons, and other avian species, and is responsible for great economic losses in the avian industry. The autoinducer 2 (AI-2) quorum sensing system is widely present in many species of gram-negative and gram-positive bacteria and has been proposed to be involved in interspecies communication. In clinical APEC strains, whether or not AI-2 affects the expression of antibiotic-related genes has not been reported...
February 9, 2018: MicrobiologyOpen
Biyun Sun, Hannah M Southam, Jonathan A Butler, Robert K Poole, Alexandre Burgun, Andrew Tarzia, F Richard Keene, J Grant Collins
A series of mononuclear ruthenium(ii) complexes containing the tetradentate ligand bis[4(4'-methyl-2,2'-bipyridyl)]-1,7-heptane have been synthesised and their biological properties examined. In the synthesis of the [Ru(phen')(bb7 )]2+ complexes (where phen' = 1,10-phenanthroline and its 5-nitro-, 4,7-dimethyl- and 3,4,7,8-tetramethyl- derivatives), both the symmetric cis-α and non-symmetric cis-β isomers were formed. However, upon standing for a number of days (or more quickly under harsh conditions) the cis-β isomer converted to the more thermodynamically stable cis-α isomer...
February 13, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
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