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https://www.readbyqxmd.com/read/28698674/insight-into-synergetic-mechanisms-of-tetracycline-and-the-selective-serotonin-reuptake-inhibitor-sertraline-in-a-tetracycline-resistant-strain-of-escherichia-coli
#1
Lili Li, Sofie Kromann, John Elmerdahl Olsen, Søren Wedel Svenningsen, Rikke Heidemann Olsen
Sertraline, an antidepressive drug, has been reported to inhibit general bacterial efflux pumps. In the present study, we report for the first time a synergistic effect of sertraline and tetracycline in a TetA-encoded tetracycline-resistant strain of Escherichia coli. Synergy between sertraline and tetracycline in an E. coli strain with TetA-mediated tetracycline resistance (E. coli APEC_O2) was assessed by the MIC and checkerboard assays. The global transcriptome of E. coli APEC_O2 exposed to ½ MIC concentrations of sertraline and/or tetracycline was analyzed to elucidate the interaction mechanism between sertraline and tetracycline...
July 12, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28690981/fnr-regulates-the-expression-of-important-virulence-factors-contributing-to-the-pathogenicity-of-avian-pathogenic-escherichia-coli
#2
Nicolle L Barbieri, Jessica A Vande Vorde, Alison R Baker, Fabiana Horn, Ganwu Li, Catherine M Logue, Lisa K Nolan
Avian pathogenic Escherichia coli (APEC) is the etiologic agent of colibacillosis, an important cause of morbidity and mortality in poultry. Though, many virulence factors associated with APEC pathogenicity are known, their regulation remains unclear. FNR (fumarate and nitrate reduction) is a well-known global regulator that works as an oxygen sensor and has previously been described as a virulence regulator in bacterial pathogens. The goal of this study was to examine the role of FNR in the regulation of APEC virulence factors, such as Type I fimbriae, and processes such as adherence and invasion, type VI secretion, survival during oxidative stress, and growth in iron-restricted environments...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28683959/-oral-diseases-in-auto-immune-polyendocrine-syndrome-type-1
#3
Emmanuelle Proust-Lemoine, Sylvie Guyot
Auto-immune polyendocrine syndrome type 1 (APS1) also called Auto-immune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare monogenic childhood-onset auto-immune disease. This autosomal recessive disorder is caused by mutations in the auto-immune regulator (AIRE) gene, and leads to autoimmunity targeting peripheral tissues. There is a wide variability in clinical phenotypes in patients with APSI, with auto-immune endocrine and non-endocrine disorders, and chronic mucocutaneous candidiasis...
July 3, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28671990/evaluation-of-escherichia-coli-isolates-from-healthy-chickens-to-determine-their-potential-risk-to-poultry-and-human-health
#4
Zachary R Stromberg, James R Johnson, John M Fairbrother, Jacquelyn Kilbourne, Angelica Van Goor, Roy Curtiss, Melha Mellata
Extraintestinal pathogenic Escherichia coli (ExPEC) strains are important pathogens that cause diverse diseases in humans and poultry. Some E. coli isolates from chicken feces contain ExPEC-associated virulence genes, so appear potentially pathogenic; they conceivably could be transmitted to humans through handling and/or consumption of contaminated meat. However, the actual extraintestinal virulence potential of chicken-source fecal E. coli is poorly understood. Here, we assessed whether fecal E. coli isolates from healthy production chickens could cause diseases in a chicken model of avian colibacillosis and three rodent models of ExPEC-associated human infections...
2017: PloS One
https://www.readbyqxmd.com/read/28669198/pathological-and-microbiological-investigations-into-cases-of-bacterial-chondronecrosis-and-osteomyelitis-in-broiler-poultry
#5
Dinidu S Wijesurendra, Anthony Neal Chamings, Rhys Nathan Bushell, Denise O' Rourke, Mark Stevenson, Marc Serge Marenda, Amir H Noormohammadi, Andrew Stent
Bacterial chondronecrosis and osteomyelitis (BCO) is increasingly recognised as a major cause of lameness in commercial broilers chickens worldwide, but the pathogenesis of the condition is incompletely understood. This was a longitudinal study of 20 commercial broiler farms in Victoria, Australia to investigate the etiology and pathology of BCO. Thorough postmortem examination was performed on culled and dead birds (n=325) from 20 different flocks at either 1 week, 4 weeks or 5 weeks of age and samples were analysed by conventional bacteriology, molecular identification of infectious organisms detected, serology and histopathology...
July 3, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28615126/unveiling-the-participation-of-avian-kinin-ornithokinin-and-its-receptors-in-the-chicken-inflammatory-response
#6
Rodrigo Guabiraba, Damien Garrido, Geoffrey Bailleul, Angélina Trotereau, Mélanie Pinaud, Anne-Christine Lalmanach, Nathalie K Chanteloup, Catherine Schouler
Vasoactive peptides are key early mediators of inflammation released through activation of different enzymatic systems. The mammalian kinin-kallikrein (K-KLK) system produces bradykinin (BK) through proteolytic cleavage of a kininogen precursor by enzymes named kallikreins. BK acts through specific ubiquitous G-protein coupled receptors (B1R and B2R) to participate in physiological processes and inflammatory responses, such as activation of mononuclear phagocytes. In chickens, the BK-like nonapeptide ornithokinin (OK) has been shown to promote intracellular calcium increase in embryonic fibroblasts and to be vasodilatory in vivo...
June 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28599670/whole-genome-sequencing-of-an-expec-that-caused-fatal-pneumonia-at-a-pig-farm-in-changchun-china
#7
Ling-Cong Kong, Xia Guo, Zi Wang, Yun-Hang Gao, Bo-Yan Jia, Shu-Ming Liu, Hong-Xia Ma
BACKGROUND: In recent years, highly frequent swine respiratory diseases have been caused by extraintestinal pathogenic Escherichia coli (ExPEC) in China. Due to this increase in ExPECs, this bacterial pathogen has become a threat to the development of the Chinese swine industry. To investigate ExPEC pathogenesis, we isolated a strain (named SLPE) from lesioned porcine lungs from Changchun in China, reported the draft genome and performed comparative genomic analyses. RESULTS: Based on the gross post-mortem examination, bacterial isolation, animal regression test and 16S rRNA gene sequence analysis, the pathogenic bacteria was identified as an ExPEC...
June 9, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28594893/pandemic-extra-intestinal-pathogenic-escherichia-coli-expec-clonal-group-o6-b2-st73-as-a-cause-of-avian-colibacillosis-in-brazil
#8
Marcos Paulo Vieira Cunha, Andre Becker Saidenberg, Andrea Micke Moreno, Antonio José Piantino Ferreira, Mônica Aparecida Midolli Vieira, Tânia Aparecida Tardelli Gomes, Terezinha Knöbl
Extra-intestinal pathogenic Escherichia coli (ExPEC) represent an emerging pathogen, with pandemic strains increasingly involved in cases of urinary tract infections (UTIs), bacteremia, and meningitis. In addition to affecting humans, the avian pathotype of ExPEC, avian pathogenic E. coli (APEC), causes severe economic losses to the poultry industry. Several studies have revealed overlapping characteristics between APEC and human ExPEC, leading to the hypothesis of a zoonotic potential of poultry strains. However, the description of certain important pandemic clones, such as Sequence Type 73 (ST73), has not been reported in food sources...
2017: PloS One
https://www.readbyqxmd.com/read/28567288/gad-antibody-associated-limbic-encephalitis-in-a-young-woman-with-apeced
#9
Anna Kopczak, Adrian-Minh Schumacher, Sandra Nischwitz, Tania Kümpfel, Günter K Stalla, Matthias K Auer
The autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a genetic disorder caused by a mutation in the autoimmune regulator (AIRE) gene. Immune deficiency, hypoparathyroidism and Addison's disease due to autoimmune dysfunction are the major clinical signs of APECED. We report on a 21-year-old female APECED patient with two inactivating mutations in the AIRE gene. She presented with sudden onset of periodic nausea. Adrenal insufficiency was diagnosed by means of the ACTH stimulation test...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28536675/an-overview-of-two-component-signal-transduction-systems-implicated-in-extra-intestinal-pathogenic-e-coli-infections
#10
REVIEW
Erin J Breland, Allison R Eberly, Maria Hadjifrangiskou
Extra-intestinal pathogenic E. coli (ExPEC) infections are common in mammals and birds. The predominant ExPEC types are avian pathogenic E. coli (APEC), neonatal meningitis causing E. coli/meningitis associated E. coli (NMEC/MAEC), and uropathogenic E. coli (UPEC). Many reviews have described current knowledge on ExPEC infection strategies and virulence factors, especially for UPEC. However, surprisingly little has been reported on the regulatory modules that have been identified as critical in ExPEC pathogenesis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28496941/chromosomal-features-of-escherichia-coli-serotype-o2-k2-an-avian-pathogenic-e-coli
#11
Steffen L Jørgensen, Egle Kudirkiene, Lili Li, Jens P Christensen, John E Olsen, Lisa Nolan, Rikke H Olsen
Escherichia coli causing infection outside the gastrointestinal system are referred to as extra-intestinal pathogenic E. coli. Avian pathogenic E. coli is a subgroup of extra-intestinal pathogenic E. coli and infections due to avian pathogenic E. coli have major impact on poultry production economy and welfare worldwide. An almost defining characteristic of avian pathogenic E. coli is the carriage of plasmids, which may encode virulence factors and antibiotic resistance determinates. For the same reason, plasmids of avian pathogenic E...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28479276/viability-assessment-of-ascaris-suum-eggs-stained-with-fluorescent-dyes-using-digital-colorimetric-analysis
#12
Magdalena Włodarczyk, Jolanta Zdybel, Marek Próchniak, Zbigniew Osiński, Jacek Karamon, Teresa Kłapeć, Tomasz Cencek
The aim of the study was to develop a method for the colorimetric evaluation of nematode eggs using appropriate instruments. The materials for the study were live and dead (inactivated) eggs of the Ascaris suum. Viability of the eggs was assessed using four different kits for fluorescent staining (for each technique, a series of photos were taken). Images of stained eggs were analysed using graphic software with RGB (red-green-blue) function. The viability of the eggs was assessed according to the relative positions of the distributions of colour intensities of live or dead eggs - distributions area's overlap index (DAOI), and distributions area's separation index (DASI) were calculated...
July 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28473898/phylogenetic-typing-and-molecular-detection-of-virulence-factors-of-avian-pathogenic-escherichia-coli-isolated-from-colibacillosis-cases-in-japanese-quail
#13
Hesam Alizade, Reza Ghanbarpour, Maziar Jajarami, Asma Askari
Colibacillosis caused by avian pathogenic Escherichia coli (APEC) is an economic threat to the poultry industry throughout the world. Some of the virulence genes may enhance the ability of E. coli isolates to grow in the tissues of broilers. The APEC strains are assigned to a few distinct phylogenetic groups. The purpose of the present study was to detect the virulence genes and phylogenetic groups of E. coli isolates from colibacillosis cases in Japanese quail in 2014 in Kerman, Iran. In the present study, one hundred and two E...
2017: Veterinary Research Forum
https://www.readbyqxmd.com/read/28458664/childhood-polyarthritis-as-early-manifestation-of-autoimmune-polyendocrinopathy-with-candidiasis-and-ectodermal-dystrophy-syndrome
#14
Maria J Gutierrez, Julieta Gilson, Jamie Zacharias, Faoud Ishmael, C April Bingham
Autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) is a rare disorder of immune dysregulation caused by mutations in the autoimmune regulator (AIRE) gene. Individuals affected with APECED develop a clinical syndrome characterized by ectodermal abnormalities, autoantibody production, and organ-specific autoimmune manifestations. Inflammatory arthritis is usually not described as a part of the syndrome, and only sporadic cases are reported. We describe the case of a preschool-age girl who presented with hypoparathyroidism, hepatitis, interstitial pneumonitis, and chronic polyarthritis at 4 years of age and was found to have two compound heterozygous disease-associated mutations in the AIRE gene...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28438362/bypass-of-an-anesthesiologist-directed-preoperative-evaluation-clinic-results-in-greater-first-case-tardiness-and-turnover-times
#15
Richard H Epstein, Franklin Dexter, Eric S Schwenk, Thomas A Witkowski
STUDY OBJECTIVE: We evaluated 4 hypotheses related to bypass of an anesthesiologist-directed preoperative evaluation clinics (APEC): 1) first-case tardiness and turnover times increased; 2) turnover times increased more than first-case tardiness; and higher American Society of Anesthesiologists Physical Status (ASA PS) resulted in both an ordered increase among ASA PS and within ASA PS in 3) first-case tardiness; and 4) turnover times. DESIGN: Retrospective observational study using electronic health records...
April 21, 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28419339/effect-of-chlorine-treatment-on-inhibition-of-e-coli-serogroup-o2-incorporation-into-7-day-old-biofilm-on-polyvinylchloride-surface
#16
P Maharjan, S Dey, G Huff, W Zhang, G K Phillips, S Watkins
Poultry waterlines are constructed using polyvinylchloride (PVC) material on which bacterial biofilm can easily form. Biofilm can harbor pathogens including avian pathogenic E. coli (APEC) strains. An in vitro evaluation was performed to determine if E. coli sero group O2 (avian pathogenic) could attach on a PVC surface that had pre-formed biofilm and if this phenomenon could be affected when water was treated with chlorine. Initially, biofilm growth was induced in PVC test coupons (15.16 cm2) for a 7-day period mimicking the waterline scenario in the first wk of poultry brooding; and then this biofilm was challenged with E...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28407484/autoreactive-t-cells-and-chronic-fungal-infection-drive-esophageal-carcinogenesis
#17
Feng Zhu, Jami Willette-Brown, Na-Young Song, Dakshayani Lomada, Yongmei Song, Liyan Xue, Zane Gray, Zitong Zhao, Sean R Davis, Zhonghe Sun, Peilin Zhang, Xiaolin Wu, Qimin Zhan, Ellen R Richie, Yinling Hu
Humans with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a T cell-driven autoimmune disease caused by impaired central tolerance, are susceptible to chronic fungal infection and esophageal squamous cell carcinoma (ESCC). However, the relationship between autoreactive T cells and chronic fungal infection in ESCC development remains unclear. We find that kinase-dead Ikkα knockin mice develop APECED-like phenotypes, including impaired central tolerance, autoreactive T cells, chronic fungal infection, and ESCCs expressing specific human ESCC markers...
April 12, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28398866/genome-wide-survey-of-genes-under-positive-selection-in-avian-pathogenic-escherichia-coli-strains
#18
Thaís Cabrera Galvão Rojas, Francisco Pereira Lobo, Jorge Augusto Hongo, Renato Vicentini, Renu Verma, Renato Pariz Maluta, Wanderley Dias da Silveira
The ability to obtain bacterial genomes from the same host has allowed for comparative studies that help in the understanding of the molecular evolution of specific pathotypes. Avian pathogenic Escherichia coli (APEC) is a group of extraintestinal strains responsible for causing colibacillosis in birds. APEC is also suggested to possess a role as a zoonotic agent. Despite its importance, APEC pathogenesis still has several cryptic pathogenic processes that need to be better understood. In this work, a genome-wide survey of eight APEC strains for genes with evidence of recombination revealed that ∼14% of the homologous groups evaluated present signs of recombination...
May 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28378963/division-of-methods-for-counting-helminths-eggs-and-the-problem-of-efficiency-of-these-methods
#19
Katarzyna Jaromin-Gleń, Teresa Kłapeć, Grzegorz Łagód, Jacek Karamon, Jacek Malicki, Agata Skowrońska, Andrzej Bieganowski
From the sanitary and epidemiological aspects, information concerning the developmental forms of intestinal parasites, especially the eggs of helminths present in our environment in: water, soil, sandpits, sewage sludge, crops watered with wastewater are very important. The methods described in the relevant literature may be classified in various ways, primarily according to the methodology of the preparation of samples from environmental matrices prepared for analysis, and the sole methods of counting and chambers/instruments used for this purpose...
March 21, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28376430/characteristics-and-emission-reduction-measures-evaluation-of-pm2-5-during-the-two-major-events-apec-and-parade
#20
Gang Wang, Shuiyuan Cheng, Wei Wei, Xiaowen Yang, Xiaoqi Wang, Jia Jia, Jianlei Lang, Zhe Lv
The measurement of PM2.5 was conducted from 20th October to 25th November 2014, and 15th August to 15th September 2015 at Beijing, Shijiazhuang, and Tangshan, China, covering two important events of Asia-Pacific Economic Cooperation (APEC) and Grand Military Parade (Parade). A series of stringent emission-reduction measures were implemented in Beijing and neighbouring regions to ensure good air quality in Beijing. PM2.5 concentrations and major components (water-soluble ions and carbonaceous aerosol) were analyzed and compared between the two events...
October 1, 2017: Science of the Total Environment
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