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https://www.readbyqxmd.com/read/27909918/review-in-vivo-optical-spectral-tissue-sensing-how-to-go-from-research-to-routine-clinical-application
#1
Lisanne L de Boer, Jarich W Spliethoff, Henricus J C M Sterenborg, Theo J M Ruers
Innovations in optical spectroscopy have helped the technology reach a point where performance previously seen only in laboratory settings can be translated and tested in real-world applications. In the field of oncology, spectral tissue sensing (STS) by means of optical spectroscopy is considered to have major potential for improving diagnostics and optimizing treatment outcome. The concept has been investigated for more than two decades and yet spectral tissue sensing is not commonly employed in routine medical practice...
December 2, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27908833/pilot-evaluation-of-a-method-to-assess-prescribers-information-processing-of-medication-alerts
#2
Alissa L Russ, Brittany L Melton, Joanne K Daggy, Jason J Saleem
BACKGROUND: Prescribers commonly receive alerts during medication ordering. Prescribers work in a complex, time-pressured environment; to enhance the effectiveness of safety alerts, the effort needed to cognitively process these alerts should be minimized. Methods to evaluate the extent to which computerized alerts support prescribers' information processing are lacking. OBJECTIVE: To develop a methodological protocol to assess the extent to which alerts support prescribers' information processing at-a-glance; specifically, the incorporation of information into working memory...
November 28, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27899825/the-role-of-pharmacists-and-pharmacy-education-in-point-of-care-testing
#3
James P Kehrer, Deborah E James
Point-of-care testing (POCT) is defined as laboratory testing conducted close to the site of patient care. Although performed originally primarily by clinical staff for acute conditions, recent advances in technology have made such testing possible for disease screening and prevention across a wide range of conditions in virtually any setting, and often by individuals with little or no training. With the ongoing evolution in POCT, numerous concerns have arisen about the quality and accuracy of the tests, comparability between multiple tests for the same endpoint, interpretation of test results, and whether and how results should be used for therapeutic decisions and included in a patient's medical record...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27876286/clinical-trials-in-a-dish
#4
David G Strauss, Ksenia Blinova
Clinical trials 'in a dish' involve testing medical therapies for safety or effectiveness in the laboratory with human tissue. This has become possible owing to recent biotechnology advances including induced pluripotent stem cells, organs-on-a-chip, and whole-genome sequencing. We provide here an overview of the landscape and highlight steps the FDA is taking to advance the science of clinical trials in a dish and to support the development and validation of new regulatory paradigms to assess drug safety using these new technologies...
November 19, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27842793/use-of-the-clinical-laboratory-in-psychiatric-practice
#5
REVIEW
Christopher Aloezos, Jonathan M Wai, Martin H Bluth, Howard Forman
In this review, the authors address the general principles of prescribing psychiatric medications and discuss how the clinical laboratory can be used to guide prescribing practices. Treatment considerations in different settings and for different medications are discussed. Because the clinical laboratory is advancing in its technology, so should the clinician's knowledge of how to use the clinical laboratory. The authors propose recommendations and a simple algorithm for how to use medication levels in blood and other fluids to guide care in medications without well-defined therapeutic windows...
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27822907/multiple-intra-hospital-transports-during-relocation-to-a-new-critical-care-unit
#6
R-A O'Leary, I Conrick-Martin, C O'Loughlin, M-R Curran, B Marsh
OBJECTIVE: Intra-hospital transport (IHT) of critically ill patients is associated with morbidity and mortality. Mass transfer of patients, as happens with unit relocation, is poorly described. We outline the process and adverse events associated with the relocation of a critical care unit. DESIGN: Extensive planning of the relocation targeted patient and equipment transfer, reduction in clinical pressure prior to the event and patient care during the relocation phase...
November 7, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27810808/biasing-of-capacitive-micromachined-ultrasonic-transducers
#7
Giosue Caliano, Giulia Matrone, Alessandro Stuart Savoia
Capacitive Micromachined Ultrasonic Transducers (CMUTs) represent an effective alternative to piezoelectric transducers for medical ultrasound imaging applications. They are micro-electromechanical (MEMS) devices fabricated using silicon micromachining techniques, developed in the last two decades in many laboratories. The interest for this novel transducer technology relies in its full compatibility with standard integrated circuit technology that makes it possible to integrate on the same chip the transducers and the electronics, thus enabling the realization of extremely low-cost and highperformance devices, including both one- or two-dimensional arrays...
October 28, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27787796/gammaretroviral-production-and-t-cell-transduction-to-genetically-retarget-primary-t-cells-against-cancer
#8
Gongbo Li, Kyungho Park, Marco L Davila
Adoptive T cell therapy has demonstrated tremendous outcomes against treatment-refractory leukemias and solid tumor malignancies. As opposed to industry-developed drugs that are manufactured and dispensed to hospitals and/or patients, T cells are produced in academic laboratories for clinical research and are a highly personalized therapy that represents a "living drug." The technology behind genetic modification of primary T cells has been developed and refined by a few academic medical centers. We anticipate that the exciting results generated by these efforts will lead to further investigation by other academic and industry institutions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27762242/the-utility-of-live-video-capture-to-enhance-debriefing-following-transcatheter-aortic-valve-replacement
#9
David P Seamans, Boshra F Louka, F David Fortuin, Bhavesh M Patel, John P Sweeney, Louis A Lanza, Patrick A DeValeria, Kim M Ezrre, Harish Ramakrishna
BACKGROUND: The surgical and procedural specialties are continually evolving their methods to include more complex and technically difficult cases. These cases can be longer and incorporate multiple teams in a different model of operating room synergy. Patients are frequently older, with comorbidities adding to the complexity of these cases. Recording of this environment has become more feasible recently with advancement in video and audio capture systems often used in the simulation realm...
October 2016: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/27762195/electronic-multidimensional-health-assessment-questionnaire-emdhaq-past-present-and-future-of-a-proposed-single-data-management-system-for-clinical-care-research-quality-improvement-and-monitoring-of-long-term-outcomes
#10
Theodore Pincus
An MDHAQ/RAPID3 (multidimensional health assessment questionnaire/routine assessment of patient index data) was developed from the HAQ over 25 years, based on observations made from completion by every patient (with all diagnoses) at every routine rheumatology visit since 1980. Modification of the HAQ was viewed as similar to improving a laboratory test, with a primary focus on clinical value for diagnosis, prognosis, and/or management, as well as feasibility for minimal effect on clinical workflow. Rigorous attention, was also directed to validity, reliability, other methodologic and technological considerations, but after clinical value and feasibility were established...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27757513/parallel-single-cell-analysis-of-active-caspase-3-7-in-apoptotic-and-non-apoptotic-cells
#11
Vojtěch Ledvina, Eva Janečková, Eva Matalová, Karel Klepárník
Analysing the chemical content of individual cells has already been proven to reveal unique information on various biological processes. Single-cell analysis provides more accurate and reliable results for biology and medicine than analyses of extracts from cell populations, where a natural heterogeneity is averaged. To meet the requirements in the research of important biologically active molecules, such as caspases, we have developed a miniaturized device for simultaneous analyses of individual cells. A stainless steel body with a carousel holder enables high-sensitivity parallel detections in eight microvials...
October 18, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27748302/the-making-of-indigenous-vascular-prosthesis
#12
Madathipat Unnikrishnan, Sidharth Viswanathan, K Balasubramaniam, C V Muraleedharan, Arthur Vijayan Lal, P V Mohanan, Meera Mohanty, Tirur Raman Kapilamoorthy
BACKGROUND & OBJECTIVES: Vascular illnesses are on the rise in India, due to increase in lifestyle diseases and demographic transition, requiring intervention to save life, organ or limbs using vascular prosthesis. The aim of this study was to develop indigenous large diameter vascular graft for treatment of patients with vascular pathologies. METHODS: The South India Textile Research Association, at Coimbatore, Tamil Nadu, India, developed seamless woven polyester (Polyethylene terephthalate) graft at its research wing...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27739366/clinical-experience-of-non-invasive-prenatal-chromosomal-aneuploidy-testing-in-190-277-patient-samples
#13
H Hu, H Liu, C Peng, T Deng, X Fu, C Chung, E Zhang, C Lu, K Zhang, Z Liang, Y Yang
OBJECTIVES: To detect trisomy 21, 18, and 13 in 190,277 clinical samples from the medical diagnostic laboratories of ten hospitals. METHODS: The study assessed the clinical performance of non-invasive prenatal testing (NIPT) in detecting trisomy 21, 18, and 13 in 190,277 clinical samples using semiconductor sequencing technology. RESULTS: NIPT participants were at a mean gestation of 17.79 weeks (range, 9-36) and age of 31.12 years (range, 18-46) at the time of testing in average...
October 13, 2016: Current Molecular Medicine
https://www.readbyqxmd.com/read/27732099/the-development-and-implementation-of-an-electronic-health-record-tool-for-monitoring-metabolic-syndrome-indices-in-patients-with-serious-mental-illness
#14
Ken Nash, Frank Ghinassi, Jaspreet S Brar, Abdulkader Alam, Mary Catherine Bohan, Kalyani Gopalan, Amie Carter, K N Roy Chengappa
OBJECTIVES: 1. A quality performance improvement (QI) project to implement an electronic screening and monitoring tool to record components of the metabolic syndrome (e-MSD) during clinic visits by persons with serious mental illness (SMI). 2. To encourage psychiatrists to use this tool in their documentation. METHODS: Working with the information technology staff, five psychiatrists developed, tested, revised and embedded the e-MSD tool into the medication management document within the electronic health record...
2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27710702/state-of-the-art-advances-in-radiation-biodosimetry-for-mass-casualty-events-involving-radiation-exposure
#15
Mary Sproull, Kevin Camphausen
With the possibility of large-scale terrorist attacks around the world, the need for modeling and development of new medical countermeasures for potential future chemical, biological, radiological and nuclear (CBRN) has been well established. Project Bioshield, initiated in 2004, provided a framework to develop and expedite research in the field of CBRN exposures. To respond to large-scale population exposures from a nuclear event or radiation dispersal device (RDD), new methods for determining received dose using biological modeling became necessary...
November 2016: Radiation Research
https://www.readbyqxmd.com/read/27706407/-south-south-cooperation-to-strengthen-the-medicines-control-laboratories-of-the-caribbean-community-caricom
#16
José María Parisi, José Luis Castro, María Celina Luque, Marta Spinetto, Patricia Saidón, James Fitzgerald
Objective To describe the benefits obtained through South-South and triangular cooperation as a potential tool for strengthening medicine quality control in official medicines control laboratories (OMCLs) of the Region of the Americas. Methods Descriptive study of the project for strengthening drug quality control in OMCLs of the Caribbean community (CARICOM). Results Staff members of Argentina's National Administration for Drugs, Food, and Medical Technology (ANMAT) provided training to professionals from Guyana, Jamaica, Suriname, and Trinidad and Tobago...
May 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/27703855/accuracy-of-conventional-identification-methods-used-for-enterobacteriaceae-isolates-in-three-nigerian-hospitals
#17
Christiana Jesumirhewe, Peter Oladejo Ogunlowo, Mitsan Olley, Burkhard Springer, Franz Allerberger, Werner Ruppitsch
BACKGROUND: Enterobacteriaceae are ubiquitously present in nature and can be found in the intestinal tract of humans and animals as commensal flora. Multidrug-resistant Enterobacteriaceae are increasingly reported and are a threat to public health implicating a need for accurate identification of the isolates to species level. In developing countries, identification of bacteria basically depends on conventional methods: culture and phenotypic methods that hamper the accurate identification of bacteria...
2016: PeerJ
https://www.readbyqxmd.com/read/27689969/an-international-randomised-controlled-trial-to-compare-targeted-intraoperative-radiotherapy-targit-with-conventional-postoperative-radiotherapy-after-breast-conserving-surgery-for-women-with-early-stage-breast-cancer-the-targit-a-trial
#18
Jayant S Vaidya, Frederik Wenz, Max Bulsara, Jeffrey S Tobias, David J Joseph, Christobel Saunders, Chris Brew-Graves, Ingrid Potyka, Stephen Morris, Hrisheekesh J Vaidya, Norman R Williams, Michael Baum
BACKGROUND: Based on our laboratory work and clinical trials we hypothesised that radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In collaboration with the industry we developed a new radiotherapy device and a new surgical operation for delivering single-dose radiation to the tumour bed - the tissues at highest risk of local recurrence. We named it TARGeted Intraoperative radioTherapy (TARGIT). From 1998 we confirmed its feasibility and safety in pilot studies...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27689831/noninvasive-physiologic-vascular-studies-a-guide-to-diagnosing-peripheral-arterial-disease
#19
Robert C Sibley, Stephen P Reis, Jarrod J MacFarlane, Mark A Reddick, Sanjeeva P Kalva, Patrick D Sutphin
Noninvasive physiologic vascular studies play an important role in the diagnosis and characterization in peripheral arterial disease (PAD) of the lower extremity. These studies evaluate the physiologic parameters of blood flow through segmental arterial pressures, Doppler waveforms, and pulse volume recordings. Collectively, they comprise a powerful toolset for defining the functionality of the arterial system, localizing the site of disease, and providing prognostic data. This technology has been widely adopted by diverse medical specialty practitioners, including radiologists, surgeons, cardiologists, and primary care providers...
September 30, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27670682/the-impact-of-automating-laboratory-request-forms-on-the-quality-of-healthcare-services
#20
Majed Al Dogether, Yahya Al Muallem, Mowafa Househ, Basema Saddik, Mohamed Khalifa
In recent decades, healthcare organizations have undergone a significant transformation with the integration of Information and Communication Technologies within healthcare operations to improve healthcare services. Various technologies such as Hospital Information Systems (HIS), Electronic Health Records (EHR) and Laboratory Information Systems (LIS) have been incorporated into healthcare services. The aim of this study is to evaluate the completeness of outpatients' laboratory paper based request forms in comparison with a electronic laboratory request system...
September 23, 2016: Journal of Infection and Public Health
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