keyword
https://read.qxmd.com/read/38533436/a-large-gastric-splenosis-mimicking-gastrointestinal-stromal-tumor-a-case-report-and-literature-review
#1
Xiaotian Li, Xianwen Hu, Pan Wang, Guiyun Hu, Bin Zhou, Jiong Cai
Splenosis pertains to the phenomenon wherein a segment of the spleen undergoes detachment and becomes embedded in other anatomical regions subsequent to traumatic rupture or therapeutic resection, and then progressively establishing blood circulation to foster the regeneration of splenic tissue. Existing literature posits that splenosis predominantly manifests within the confines of the abdominal and pelvic cavities. The objective of the current study was to present an uncommon case involving the occurrence of splenosis within the gastric myometrium, thereby contributing to the current knowledge regarding splenosis...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38524302/alternative-genome-sequencing-approaches-of-sars-cov-2-using-ion-ampliseq-technology
#2
JOURNAL ARTICLE
Md Shazid Hasan, M Shaminur Rahman, Prosanto Kumar Das, A S M Rubayet Ul Alam, Ovinu Kibria Islam, Hassan M Al-Emran, M Anwar Hossain, Iqbal Kabir Jahid
A thorough understanding of SARS-CoV-2 genetic features is compulsory to track the ongoing pandemic across multiple geographical locations of the world. Thermo Fisher Scientific USA has developed the Ion AmpliSeq SARS-CoV-2 Research Panel for the targeted sequencing of SARS-CoV-2 complete genome with high coverage and lower error rate. In this study an alternative approach of complete genome sequencing has been validated using different commercial sequencing kits to sequence the SARS-CoV-2. Amplification of cDNA with the SARS-CoV-2 primer pool was performed separately using two different master mixes: 2X environmental master mix (EM) and Platinum™ PCR SuperMix High Fidelity master mix (PM) instead of 5X Ion AmpliSeq™ HiFi Mix whereas NEBNext® Fast DNA Library Prep Set for Ion Torrent™ kit was used as an alternative to Ion AmpliSeq Library Kit Plus for other reagents...
June 2024: MethodsX
https://read.qxmd.com/read/38519155/foresight-a-generative-pretrained-transformer-for-modelling-of-patient-timelines-using-electronic-health-records-a-retrospective-modelling-study
#3
JOURNAL ARTICLE
Zeljko Kraljevic, Dan Bean, Anthony Shek, Rebecca Bendayan, Harry Hemingway, Joshua Au Yeung, Alexander Deng, Alfred Baston, Jack Ross, Esther Idowu, James T Teo, Richard J B Dobson
BACKGROUND: An electronic health record (EHR) holds detailed longitudinal information about a patient's health status and general clinical history, a large portion of which is stored as unstructured, free text. Existing approaches to model a patient's trajectory focus mostly on structured data and a subset of single-domain outcomes. This study aims to evaluate the effectiveness of Foresight, a generative transformer in temporal modelling of patient data, integrating both free text and structured formats, to predict a diverse array of future medical outcomes, such as disorders, substances (eg, to do with medicines, allergies, or poisonings), procedures, and findings (eg, relating to observations, judgements, or assessments)...
April 2024: The Lancet. Digital health
https://read.qxmd.com/read/38517818/establishment-and-application-of-drug-utilization-evaluation-applying-the-weighted-topsis-method-a-study-based-on-real-world-data-of-tislelizumab
#4
JOURNAL ARTICLE
Yang Li, Qianxi Chen, Tao Zhu, Shaohuan Lu, Canhua Liang, Guangzhao Wang, Xuefeng Wu, Guangyi Meng
BACKGROUND: How to comprehensively evaluate the rationality of drug use is a challenging issue. OBJECTIVE: To establish the evaluation index of the effective use of tislelizumab, so as to ensure its higher rationality and normalization in clinical application. METHODS: Based on the indications, drug instructions, and relevant guidelines of the National Basic Medical Insurance Restriction Catalogue, a retrospective analysis and evaluation of 286 cases of using tislelizumab injection in our hospital from January to December 2022 were conducted using the weighted technique for order of preference by similarity to ideal solution (TOPSIS) method...
January 22, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38517441/intraoperative-evaluation-of-breast-tissues-during-breast-cancer-operations-using-the-masspec-pen
#5
JOURNAL ARTICLE
Kyana Y Garza, Mary E King, Chandandeep Nagi, Rachel J DeHoog, Jialing Zhang, Marta Sans, Anna Krieger, Clara L Feider, Alena V Bensussan, Michael F Keating, John Q Lin, Min Woo Sun, Robert Tibshirani, Christopher Pirko, Kirtan A Brahmbhatt, Ahmed R Al-Fartosi, Alastair M Thompson, Elizabeth Bonefas, James Suliburk, Stacey A Carter, Livia S Eberlin
IMPORTANCE: Surgery with complete tumor resection remains the main treatment option for patients with breast cancer. Yet, current technologies are limited in providing accurate assessment of breast tissue in vivo, warranting development of new technologies for surgical guidance. OBJECTIVE: To evaluate the performance of the MasSpec Pen for accurate intraoperative assessment of breast tissues and surgical margins based on metabolic and lipid information. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study conducted between February 23, 2017, and August 19, 2021, the mass spectrometry-based device was used to analyze healthy breast and invasive ductal carcinoma (IDC) banked tissue samples from adult patients undergoing breast surgery for ductal carcinomas or nonmalignant conditions...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38516992/transforming-diagnostics-the-implementation-of-digital-pathology-in-clinical-laboratories
#6
REVIEW
Christine Bruce, Ioannis Prassas, Mark Mokhtar, Blaise Clarke, Elaria Youssef, Catherine Wang, George M Yousef
Digital pathology (DP) has emerged as a cutting-edge technology that promises to revolutionise diagnostics in clinical laboratories. This perspective article explores the implementation planning and considerations of DP in a single multicentre institution in Canada, the University Health Network, discussing benefits, challenges, potential implications and considerations for future adopters. We examine the transition from traditional microscopy to digital slide scanning and its impact on pathology practice, patient care and medical research...
March 22, 2024: Histopathology
https://read.qxmd.com/read/38510932/enhancement-of-handwritten-text-recognition-using-ai-based-hybrid-approach
#7
JOURNAL ARTICLE
Supriya Mahadevkar, Shruti Patil, Ketan Kotecha
Handwritten text recognition (HTR) within computer vision and image processing stands as a prominent and challenging research domain, holding significant implications for diverse applications. Among these, it finds usefulness in reading bank checks, prescriptions, and deciphering characters on various forms. Optical character recognition (OCR) technology, specifically tailored for handwritten documents, plays a pivotal role in translating characters from a range of file formats, encompassing both word and image documents...
June 2024: MethodsX
https://read.qxmd.com/read/38510279/smart-hospital-achieving-interoperability-and-raw-data-collection-from-medical-devices-in-clinical-routine
#8
JOURNAL ARTICLE
Eimo Martens, Hans-Ulrich Haase, Giulio Mastella, Andreas Henkel, Christoph Spinner, Franziska Hahn, Congyu Zou, Augusto Fava Sanches, Julia Allescher, Daniel Heid, Elena Strauss, Melanie-Maria Maier, Mark Lachmann, Georg Schmidt, Dominik Westphal, Tobias Haufe, David Federle, Daniel Rueckert, Martin Boeker, Matthias Becker, Karl-Ludwig Laugwitz, Alexander Steger, Alexander Müller
INTRODUCTION: Today, modern technology is used to diagnose and treat cardiovascular disease. These medical devices provide exact measures and raw data such as imaging data or biosignals. So far, the Broad Integration of These Health Data into Hospital Information Technology Structures-Especially in Germany-is Lacking, and if data integration takes place, only non-Evaluable Findings are Usually Integrated into the Hospital Information Technology Structures. A Comprehensive Integration of raw Data and Structured Medical Information has not yet Been Established...
2024: Frontiers in digital health
https://read.qxmd.com/read/38501624/gis-technologies-in-the-study-of-natural-results-especially-dangerous-diseases-in-kazakhstan
#9
JOURNAL ARTICLE
M Syzdykov, L Yeralieva, Z Zhumadilova, S Daulbaeva, V Sadovskaya, A Kussainova, A Rysbayev, N Kadyrmanov
This study explores the application of GIS technologies in analyzing and visualizing spatial structures of especially dangerous infections (EPI) in Kazakhstan. International collaborations have facilitated projects studying the focal patterns of diseases, improving data analysis and visualization. Extensive electronic databases resulting from field research on EPI foci have elevated the study's depth. The dynamics of natural foci, influenced by intraspecific structures of infection carriers, are impacted by industrial and agricultural developments, urban expansions, and climate change...
January 2024: Georgian Medical News
https://read.qxmd.com/read/38501164/progesterone-in-pregnancy-evidence-based-strategies-to-reduce-miscarriage-and-enhance-assisted-reproductive-technology
#10
JOURNAL ARTICLE
Ting-Jung Lai, Sen-Wen Teng, Cheng-Kun Chang, Chen-Yu Huang
The incidence of miscarriage in early pregnancy, between 5-20 weeks, is common, with a prevalence of between 5-22% of all pregnancies. Miscarriage can have physical, social, and mental health impacts on women and their families. In societies such as Taiwan, where the birth rate is falling and life expectancy is increasing, there is concern that factors that reduce birth rates will have detrimental economic and societal effects. Progesterone has a significant role in maintaining early and successful pregnancy to term...
March 8, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38501148/assessing-the-efficacy-of-active-learning-to-support-student-performance-across-undergraduate-programmes-in-biomedical-science
#11
JOURNAL ARTICLE
D J Lees-Murdock, D Khan, R Irwin, J Graham, V Hinch, B O'Hagan, S McClean
Introduction: Active learning is a useful tool to enhance student engagement and support learning in diverse educational situations. We aimed to assess the efficacy of an active learning approach within a large interprofessional first year Medical Cell Biology module taken by six healthcare programmes across the School of Biomedical Sciences at Ulster University, United Kingdom. Materials and methods: An active learning approach was developed for weekly formative assessment using Smartwork to design a weekly interactive multiple-choice quiz to reinforce key concepts specifically for each lecture...
2024: British Journal of Biomedical Science
https://read.qxmd.com/read/38500254/comparative-accuracy-of-intraoral-and-extraoral-digital-workflows-for-short-span-implant-supported-fixed-partial-denture-fabrication-an-in-vitro-study
#12
JOURNAL ARTICLE
Manawar Ahmad Mansoor, Mohammed E Sayed, Hina Naim Abdul, Meshal Saleh Zaidan, Thamer Mohammad Hakami, Mohammed Abdullah Dighriri, Saeed M Alqahtani, Mohammed A Alfaifi, Majed S Altoman, Hossam F Jokhadar, Saad Saleh AlResayes, Mohammed H AlWadei, Asayil Ibrahim Jundus, Abeer Mohammed Komosany, Hind Ziyad AlNajjar
BACKGROUND The advent of digital impressions using computer-aided design and manufacturing technology (CAD/CAM) has simplified and improved the fabrication of implant prostheses in dentistry. The conventional impression has several drawbacks, including tray selection, material type, impression technique, impression disinfection, and cast model storage. The inaccuracies caused by distortion and contraction of impression material can be minimized with digital impressions. This study aimed to compare digital dental impressions of 10 working casts made using the Pindex laser removable die system to fabricate parallel drill channels vs 10 working casts made using the Di-Lok plastic tray removable die system...
March 19, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38499605/dynamic-associations-between-glucose-and-ecological-momentary-cognition-in-type-1-diabetes
#13
JOURNAL ARTICLE
Z W Hawks, E D Beck, L Jung, L M Fonseca, M J Sliwinski, R S Weinstock, E Grinspoon, I Xu, R W Strong, S Singh, H P A Van Dongen, M R Frumkin, J Bulger, M J Cleveland, K Janess, Y C Kudva, R Pratley, M R Rickels, S R Rizvi, N S Chaytor, L T Germine
Type 1 diabetes (T1D) is a chronic condition characterized by glucose fluctuations. Laboratory studies suggest that cognition is reduced when glucose is very low (hypoglycemia) and very high (hyperglycemia). Until recently, technological limitations prevented researchers from understanding how naturally-occurring glucose fluctuations impact cognitive fluctuations. This study leveraged advances in continuous glucose monitoring (CGM) and cognitive ecological momentary assessment (EMA) to characterize dynamic, within-person associations between glucose and cognition in naturalistic environments...
March 18, 2024: NPJ Digital Medicine
https://read.qxmd.com/read/38487974/implementing-virtual-reality-technology-to-teach-medical-college-systemic-anatomy-a-pilot-study
#14
JOURNAL ARTICLE
Meng-Lin Liao, Chi-Chuan Yeh, June-Horng Lue, Ming-Fong Chang
It can be difficult for some students to learn three-dimensional anatomical structure concepts. While virtual reality (VR) systems have been reported as helpful for learning, there has been scarce research on either VR teaching strategies or the influence of visually induced motion sickness (VIMS) in the context of large anatomy classes (i.e., over 100 students). The study thus aimed to (1) establish a VR anatomy instruction video for a large class; (2) determine how many students experience VIMS when watching a VR anatomy instruction video; (3) evaluate the influence of VIMS on VR anatomy video-based learning; and (4) examine whether a small screen size alleviates VIMS...
March 15, 2024: Anatomical Sciences Education
https://read.qxmd.com/read/38482747/cell-free-dna-screening-for-single-gene-disorders
#15
JOURNAL ARTICLE
Brighton S Goodhue, Sky E Danity, Neeta Vora, Jeffrey A Kuller, Matthew R Grace
IMPORTANCE: In pregnancy, cell-free DNA (cfDNA) represents short fragments of placental DNA released into the maternal blood stream through natural cell death. Noninvasive prenatal screening with cfDNA is commonly used in pregnancy to screen for common aneuploidies. This technology continues to evolve, and laboratories now offer cfDNA screening for single-gene disorders. OBJECTIVE: This article aims to review cfDNA screening for single-gene disorders including the technology, current syndromes for which screening may be offered, limitations, and current recommendations...
March 2024: Obstetrical & Gynecological Survey
https://read.qxmd.com/read/38482624/advances-in-the-treatment-of-kidney-disorders-using-mesenchymal-stem-cells
#16
JOURNAL ARTICLE
Shivam Rajput, Rishabha Malviya, Prerna Uniyal
Renal disease is a medical condition that poses a potential threat to the life of an individual and is related to substantial morbidity and mortality rates in clinical environments. The aetiology of this condition is influenced by multiple factors, and its incidence tends to increase with progressive aging. Although supportive therapy and kidney transplantation have potential advantages, they also have limitations in terms of mitigating the progression of KD. Despite significant advancements in the domain of supportive therapy, mortality rates in patients continue to increase...
March 13, 2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38480838/first-use-of-silicon-carbide-detectors-with-graphene-enhanced-contacts-for-medical-dosimetry
#17
JOURNAL ARTICLE
Ivan Lopez Paz, Celeste Fleta, Faustino Gomez, Diego Miguel González, Giulio Pellegrini
Silicon Carbide (SiC) is a radiation hard wide bandgap semiconductor, which makes it an interesting alternative for radiation detector fabrication, with potential applications such as High Energy Physics, synchrotron and radiotherapy instrumentation. In addition, by reducing the amount of metal over the active area of said detectors (typically used for electrical connectivity with the implant of the pn-junction) unwanted effects from secondary interactions which can affect the accuracy of the measurement can be diminished, essential to meet the medical standards of precision...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479404/ultrasound-guided-high-intensity-focused-ultrasound-ablation-for-uterine-arteriovenous-fistula-a-case-series
#18
JOURNAL ARTICLE
Fang Li, Hua Tao, Jing Chen, Li Wang, Yini Wei, Xiajuan Wu, Yu Zhang, Dingyuan Zeng
PURPOSE: To evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) ablation in the treatment of uterine arteriovenous fistula (UAVF). MATERIALS AND METHODS: This case series included three patients diagnosed with acquired UAVF. All patients underwent routine laboratory tests, electrocardiography (ECG), chest X-ray, ultrasound, and pelvic contrast-enhanced magnetic resonance imaging (MRI). HIFU treatment was performed under sedation and analgesia using a Model JC Focused Ultrasound Tumor Therapeutic System (made by Chongqing Haifu Medical Technology Co...
2024: International Journal of Hyperthermia
https://read.qxmd.com/read/38472203/numerosity-estimation-of-virtual-humans-as-a-digital-robotic-marker-for-hallucinations-in-parkinson-s-disease
#19
JOURNAL ARTICLE
Louis Albert, Jevita Potheegadoo, Bruno Herbelin, Fosco Bernasconi, Olaf Blanke
Hallucinations are frequent non-motor symptoms in Parkinson's disease (PD) associated with dementia and higher mortality. Despite their high clinical relevance, current assessments of hallucinations are based on verbal self-reports and interviews that are limited by important biases. Here, we used virtual reality (VR), robotics, and digital online technology to quantify presence hallucination (vivid sensations that another person is nearby when no one is actually present and can neither be seen nor heard) in laboratory and home-based settings...
March 12, 2024: Nature Communications
https://read.qxmd.com/read/38470938/validation-of-touchb-a-non-invasive-haemoglobin-estimation-effective-for-normal-ranges-needs-improvement-for-anaemia-detection
#20
JOURNAL ARTICLE
Yogish Channa Basappa, Sumanth Mallikarjuna Majgi, Shashidhar Byrappa Shashidhar, Prashanth Nuggehalli Srinivas
Non-invasive methods for haemoglobin estimation hold enormous potential for early detection and treatment of anaemia, especially in limited resource settings. We sought to validate the diagnostic accuracy of ToucHb, a non-invasive haemoglobin estimation device available in the Indian market. We prospectively evaluated the diagnostic performance of the ToucHb device using the Automated complete blood count (CBC) method as the gold standard. Persons referred for haemoglobin estimation to the central laboratory of the government medical college hospital in Mysore, southern India were included in the study...
2024: PLOS Glob Public Health
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