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Medical laboratory technology

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https://www.readbyqxmd.com/read/29329957/safety-and-tolerability-of-a-novel-polyclonal-human-anti-mers-coronavirus-antibody-produced-from-transchromosomic-cattle-a-phase-1-randomised-double-blind-single-dose-escalation-study
#1
John H Beigel, Jocelyn Voell, Parag Kumar, Kanakatte Raviprakash, Hua Wu, Jin-An Jiao, Eddie Sullivan, Thomas Luke, Richard T Davey
BACKGROUND: Middle East respiratory syndrome (MERS) is a severe respiratory illness with an overall mortality of 35%. There is no licensed or proven treatment. Passive immunotherapy approaches are being developed to prevent and treat several human medical conditions where alternative therapeutic options are absent. We report the safety of a fully human polyclonal IgG antibody (SAB-301) produced from the hyperimmune plasma of transchromosomic cattle immunised with a MERS coronavirus vaccine...
January 9, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29327339/electronic-registry-for-the-management-of-childhood-obesity-in-greece
#2
Penio Kassari, Panagiotis Papaioannou, Antonis Billiris, Haralampos Karanikas, Stergiani Eleftheriou, Eleftherios Thireos, Yannis Manios, George P Chrousos, Evangelia Charmandari
BACKGROUND: Obesity in childhood and adolescence represents a major health problem in our century. In Greece, more than 30-35% of children and adolescents are either overweight or obese. MATERIALS AND METHODS: Using information and communication technologies, we developed a "National Registry for the Prevention and Management of Overweight and Obesity in Childhood and Adolescence" for guidance and training of Pediatricians and General Practitioners. The application supports interoperability with other national infrastructures and multi-layered security spanning preventive, detective and administrative controls...
January 11, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29320901/if-we-keep-doing-what-we-re-doing-we-ll-keep-getting-what-we-re-getting-a-need-to-rethink-academic-medicine
#3
Michael Wilkes, Christine Cassel, Marc Klau
PURPOSE: For generations there have been warnings of the need to reform medical education at all levels. Today the voices pushing reform are louder, the need is greater, and there is an urgency not seen before. Approaches that have worked in the past to train physicians are no longer as relevant today as demographics, disease patterns, human resources, practice behaviors, technology, and attention to costs demand new collaborative approaches to clinical practice. To prepare for this practice tomorrow's doctors will need a different type of educational model, a different type of learning, in different environments, often taught by different faculty...
January 10, 2018: Medical Teacher
https://www.readbyqxmd.com/read/29317386/the-perceived-ease-of-use-and-usefulness-of-loop-evaluation-and-content-analysis-of-a-web-based-clinical-collaboration-system
#4
Allison M Kurahashi, Jennifer N Stinson, Margaret van Wyk, Stephanie Luca, Trevor Jamieson, Peter Weinstein, Joseph A Cafazzo, Bhadra Lokuge, Eyal Cohen, Adam Rapoport, Amna Husain
BACKGROUND: Patients with complex health care needs require the expertise of many health care providers. Communication, collaboration, and patient-centered care positively impact care quality and patient outcomes. Few technologies exist that facilitate collaboration between providers across settings of care and also engage the patient. We developed a Web-based clinical collaboration system, Loop, to address this gap. The likelihood of a technological system's uptake is associated with its perceived ease of use and perceived usefulness...
January 9, 2018: JMIR Human Factors
https://www.readbyqxmd.com/read/29313034/the-wyss-institute-a-new-model-for-medical-technology-innovation-and-translation-across-the-academic-industrial-interface
#5
REVIEW
Mary Tolikas, Ayis Antoniou, Donald E Ingber
The Wyss Institute for Biologically Inspired Engineering at Harvard University was formed based on the recognition that breakthrough discoveries cannot change the world if they never leave the laboratory. The Institute's mission is to discover the biological principles that Nature uses to build living things, and to harness these insights to create biologically inspired engineering innovations to advance human health and create a more sustainable world. Since its launch in 2009, the Institute has developed a new model for innovation, collaboration, and technology translation within academia, breaking "silos" to enable collaborations that cross institutional and disciplinary barriers...
September 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29298450/a-statewide-medication-management-system-health-information-exchange-to-support-drug-therapy-optimization-by-pharmacists-across-the-continuum-of-care
#6
Karen Pellegrin, Francis Chan, Natalie Pagoria, Sheena Jolson-Oakes, Reece Uyeno, Andrew Levin
BACKGROUND:  While evidence generally supports the use of medication management technology, systems are typically implemented and evaluated piecemeal rather than as part of a comprehensive model for medication management. Systems to support drug therapy optimization, increasingly a key role of pharmacists in our healthcare system, have not yet been reported. OBJECTIVE:  Our objective is to describe the design, implementation, and use of health information technology to support the hospital and community pharmacists' management of medications for high-risk patients statewide in the "Pharm2Pharm" model of care...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29296502/automated-multimodal-spectral-histopathology-for-quantitative-diagnosis-of-residual-tumour-during-basal-cell-carcinoma-surgery
#7
Radu Boitor, Kenny Kong, Dustin Shipp, Sandeep Varma, Alexey Koloydenko, Kusum Kulkarni, Somaia Elsheikh, Tom Bakker Schut, Peter Caspers, Gerwin Puppels, Martin van der Wolf, Elena Sokolova, T E C Nijsten, Brogan Salence, Hywel Williams, Ioan Notingher
Multimodal spectral histopathology (MSH), an optical technique combining tissue auto-fluorescence (AF) imaging and Raman micro-spectroscopy (RMS), was previously proposed for detection of residual basal cell carcinoma (BCC) at the surface of surgically-resected skin tissue. Here we report the development of a fully-automated prototype instrument based on MSH designed to be used in the clinic and operated by a non-specialist spectroscopy user. The algorithms for the AF image processing and Raman spectroscopy classification had been first optimised on a manually-operated laboratory instrument and then validated on the automated prototype using skin samples from independent patients...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29289168/hybrid-setup-for-micro-and-nano-computed-tomography-in-the-hard-x-ray-range
#8
Christian Fella, Andreas Balles, Randolf Hanke, Arndt Last, Simon Zabler
With increasing miniaturization in industry and medical technology, non-destructive testing techniques are an area of ever-increasing importance. In this framework, X-ray microscopy offers an efficient tool for the analysis, understanding, and quality assurance of microscopic samples, in particular as it allows reconstructing three-dimensional data sets of the whole sample's volume via computed tomography (CT). The following article describes a compact X-ray microscope in the hard X-ray regime around 9 keV, based on a highly brilliant liquid-metal-jet source...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29286493/twenty-five-years-of-the-national-academy-of-medical-sciences-of-ukraine-progress-and-priorities-for-future-of-radiation-medicine-and-biology
#9
D Bazyka
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population. It was extremely needed for the minimization of Chornobyl medical consequences. This choice was related to a growing recognition of the scientific research in fulfilling the Сenter's mission - study of the effects of low dose radiation on human body and radiation protection of the exposed population...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29275579/-risk-factors-associated-with-massive-drainage-after-posterior-spinal-orthopaedic-surgery-for-adolescent-scoliosis
#10
N Li, R Jia, X P Gu, Z L Ma
Objective: To identify risk factors that influence the massive drainage after posterior spinal orthopaedic surgery for adolescent scoliosis. Methods: A total of 1 461 patients from 11 to 18 years old diagnosed with adolescent scoliosis who underwent first posterior spinal orthopaedic surgery in affiliated Drum Tower Hospital, Medical School of Nanjing University between November 2010 and October 2015 were retrospectively reviewed. Patients were categorized on the basis of massive or normal drainage, with the boundary 30(th) percentile of drainage/estimated blood volume...
November 28, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29273576/opinion-redefining-the-role-of-the-physician-in-laboratory-medicine-in-the-context-of-emerging-technologies-personalised-medicine-and-patient-autonomy-4p-medicine
#11
REVIEW
Matthias Orth, Maria Averina, Stylianos Chatzipanagiotou, Gilbert Faure, Alexander Haushofer, Vesna Kusec, Augusto Machado, Siraj A Misbah, Wytze Oosterhuis, Kari Pulkki, Patrick J Twomey, Eberhard Wieland
The role of clinical pathologists or laboratory-based physicians is being challenged on several fronts-exponential advances in technology, increasing patient autonomy exercised in the right to directly request tests and the use of non-medical specialists as substitutes. In response, clinical pathologists have focused their energies on the pre-analytical and postanalytical phases of Laboratory Medicine thus emphasising their essential role in individualised medical interpretation of complex laboratory results...
December 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29250700/ethical-dilemmas-in-communicating-bad-news-following-histopathology-examination
#12
Dan Alexandru Constantin, IonuŢ Horia Cioriceanu, Marilena Monica ţânŢu, Daniela Popa, Dana Bădău, Victoria Burtea, Gabriela CodruŢa Nemet, Liliana Marcela Rogozea
PURPOSE: The study proposes an analysis of the ethical aspects that occur in communicating bad news following histopathology laboratory tests in medical practice, in particular in the case of the anatomical pathology diagnosis confirming a medical condition of poor prognosis. BACKGROUND: Over the last decades, the progress of science and technology in the medical field, as well as the explosive increase of specialist information available on the Internet have led to unprecedented ethical issues related to the communication modality of histopathology test results to patients...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29240341/finland-establishing-the-internet-of-genomics-and-health-data
#13
Aarno Palotie, Samuli Ripatti
Genomic data, i.e. measurement of variation in the complete genome has revolutionized genetic research and changed our understanding of the pathogenetic mechanisms of diseases. Genomic data in combination with Finnish special strengths - population history, the nation's comprehensive health records and a strong research tradition in genetic epidemiology - has made Finland a testing laboratory for diseases of public health importance. At the same time, genomic research has changed into statistical evaluation of large masses of data - big data...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29229513/modelling-drug-release-from-polymer-free-coronary-stents-with-microporous-surfaces
#14
Tuoi T N Vo, Sarah Morgan, Christopher McCormick, Sean McGinty, Sean McKee, Martin Meere
Traditional coronary drug-eluting stents (DES) are made from metal and are coated with a permanent polymer film containing an anti-proliferative drug. Subsequent to stent deployment in a diseased coronary artery, the drug releases into the artery wall and helps prevent restenosis by inhibiting the proliferation of smooth muscle cells. Although this technology has proven to be remarkably successful, there are ongoing concerns that the presence of a polymer in the artery can lead to deleterious medical complications, such as late stent thrombosis...
December 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29221539/partnership-conference
#15
John A Bartlett, Sarah Cao, Blandina Mmbaga, Xu Qian, Michael Merson, Randall Kramer
BACKGROUND: The Duke Global Health Institute (DGHI) was founded in 2006 with a goal to foster interdisciplinary global health education and research across Duke University and Duke Medical Center. Critical to achieving this goal is the need to develop and sustain strong international partnerships. OBJECTIVE: To host a conference with multiple international partners and strengthen existing relationships. METHODS: After a deliberate year-long planning process, DGHI convened a Partnership Conference with its international partners on the Duke University campus in conjunction with its 10th Anniversary Celebration...
May 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29207568/recent-advances-in-fluorescence-lifetime-analytical-microsystems-contact-optics-and-cmos-time-resolved-electronics
#16
REVIEW
Liping Wei, Wenrong Yan, Derek Ho
Fluorescence spectroscopy has become a prominent research tool with wide applications in medical diagnostics and bio-imaging. However, the realization of combined high-performance, portable, and low-cost spectroscopic sensors still remains a challenge, which has limited the technique to the laboratories. A fluorescence lifetime measurement seeks to obtain the characteristic lifetime from the fluorescence decay profile. Time-correlated single photon counting (TCSPC) and time-gated techniques are two key variations of time-resolved measurements...
December 4, 2017: Sensors
https://www.readbyqxmd.com/read/29199153/retrospective-assessment-of-an-assisted-reproductive-technology-method
#17
Siham Aboulmakarim, Amal Benbella, Houyam Hardizi, Rachid Bezad
The validation of methods in medical biology is a fundamental step in which the laboratory defines its analytical objectives, characterizes the performance of the technique according to the level of quality it fixes and discusses the results obtained. The objective of this work is to contribute to respect the requirements of ISO 15189 in terms of performance verification of a manual qualitative technique of medically assisted procreation (PMA): morphological identification of the oocyte, the zygote and the embryo, harmonization of professional practices and assessment of competences by associating the bibliographic approach and above all by justifying its choices...
December 4, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29198733/virtual-medicine-utilization-of-the-advanced-cardiac-imaging-patient-avatar-for-procedural-planning-and-facilitation
#18
REVIEW
Jerold S Shinbane, Leslie A Saxon
Advances in imaging technology have led to a paradigm shift from planning of cardiovascular procedures and surgeries requiring the actual patient in a "brick and mortar" hospital to utilization of the digitalized patient in the virtual hospital. Cardiovascular computed tomographic angiography (CCTA) and cardiovascular magnetic resonance (CMR) digitalized 3-D patient representation of individual patient anatomy and physiology serves as an avatar allowing for virtual delineation of the most optimal approaches to cardiovascular procedures and surgeries prior to actual hospitalization...
November 16, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29196473/cell-scientist-to-watch-lukas-kapitein
#19
(no author information available yet)
Lukas Kapitein studied physics at the VU University in Amsterdam and graduated with a master's degree in experimental physics. He went on to do his PhD in the research groups of Christoph Schmidt and Erwin Peterman on the motility of mitotic kinesins, and in 2007, he won the biannual best thesis award from the Dutch society for Biophysics and Biomedical Technology. Lukas then joined the laboratory of Casper Hoogenraad at the Erasmus Medical Center in Rotterdam to work on the cytoskeleton and polarised cargo transport in neurons...
December 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29194998/emerging-technologies-for-home-based-semen-analysis
#20
REVIEW
S Yu, M Rubin, S Geevarughese, J S Pino, H F Rodriguez, W Asghar
With about 70 million cases of infertility worldwide, half of which are caused by male factors, sperm analysis is critical to determine male fertility potential. Conventional semen analysis methods involve complex and manual inspection with a microscope, and these methods are labor intensive and can take several days. Due to unavailability of rapid, convenient, and user-friendly semen analysis tools, many men do not seek medical evaluation, especially in resource-constrained settings. Furthermore, as conventional methods have to be conducted in the laboratories, many men are unwilling to be tested as a result of social stigma in certain regions of the world...
December 1, 2017: Andrology
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