Adam Stafford, Stephanie Rimmer, Mark Gilchrist, Kristi Sun, Ella P Davies, Claire S Waddington, Christopher Chiu, Darius Armstrong-James, Thomas Swaine, Frances Davies, Carlos H M Gómez, Vagish Kumar, Ahmad ElHaddad, Zaid Awad, Christopher Smart, Borja Mora-Peris, David Muir, Paul Randell, Joanna Peters, Meera Chand, Clare E Warrell, Tommy Rampling, Graham Cooke, Sara Dhanji, Vivienne Campbell, Carys Davies, Sana Osman, Aula Abbara
A 48-year-old man with poorly controlled HIV presented with severe human monkeypox virus (hMPXV) infection, having completed 2 weeks of tecovirimat at another hospital. He had painful, ulcerating skin lesions on most of his body and oropharyngeal cavity, with subsequent Ludwig's angina requiring repeated surgical interventions. Despite commencing a second, prolonged course of tecovirimat, he did not objectively improve, and new lesions were still noted at day 24. Discussion at the UK National Health Service England High Consequence Infectious Diseases Network recommended the use of 3% topical and then intravenous cidofovir, which was given at 5 mg/kg; the patient made a noticeable improvement after the first intravenous dose...
February 8, 2023: Lancet Infectious Diseases