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https://www.readbyqxmd.com/read/29145093/proteomic-profile-and-toxicity-pathway-analysis-in-zebrafish-embryos-exposed-to-bisphenol-a-and-di-n-butyl-phthalate-at-environmentally-relevant-levels
#1
Xing Dong, Xuchun Qiu, Shunlong Meng, Hai Xu, Xiangyang Wu, Ming Yang
Bisphenol A (BPA) and di-n-butyl phthalate (DBP) are well-known endocrine-disrupting chemicals (EDCs) that have human health risks. Chronic exposure to BPA and DBP increases the occurrence of human disease. Despite the potential for exposure in embryonic development, the mechanism of action of BPA and DBP on vertebrate development and disease still remains unclear. In the present study, we identified proteins and protein networks that are perturbed by BPA and DBP during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to environmentally relevant levels of BPA (10 μg/L) and DBP (50 μg/L) for 96 h...
November 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29102625/reprint-of-role-of-g-protein-coupled-estrogen-receptor-gper-gpr30-in-maintenance-of-meiotic-arrest-in-fish-oocytes
#2
REVIEW
Peter Thomas
An essential role for GPER (formerly known as GPR30) in regulating mammalian reproduction has not been identified to date, although it has shown to be involved in the regulation a broad range of other estrogen-dependent functions. In contrast, an important reproductive role for GPER in the maintenance of oocyte meiotic arrest has been identified in teleost fishes, which is briefly reviewed here. Recent studies have clearly shown that ovarian follicle production of estradiol-17β (E2) maintains meiotic arrest in several teleost species through activation of GPER coupled to a stimulatory G protein (Gs) on oocyte plasma membranes, resulting in stimulation of cAMP production and maintenance of elevated cAMP levels...
November 2, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29055862/juvenile-exposure-to-bisphenol-a-promotes-ovarian-differentiation-but-suppresses-its-growth-potential-involvement-of-pituitary-follicle-stimulating-hormone
#3
Weiting Chen, Shuk-Wa Lau, Yuqin Fan, Rudolf S S Wu, Wei Ge
Bisphenol A (BPA), a plastic monomer and plasticizer, is commonly used in plastics industry, and it has been well documented to be an estrogenic endocrine disrupter. In the present study, we investigated the effect of early (juvenile) exposure to BPA on the hypothalamic-pituitary-gonad (HPG) axis in the zebrafish. Estradiol (E2) and testosterone (T) were also included as positive and negative controls respectively. Juvenile zebrafish were exposed to BPA (1 and 10μM), E2 (10nM) and T (10nM) from 20 to 40 dpf (days post-fertilization), the period of sex/gonadal differentiation, followed by histological and expression analyses at 40 dpf...
October 14, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29027980/the-plasticizer-bisphenol-a-perturbs-the-hepatic-epigenome-a-systems-level-analysis-of-the-mirnome
#4
Ludivine Renaud, Willian A da Silveira, E Starr Hazard, Jonathan Simpson, Silvia Falcinelli, Dongjun Chung, Oliana Carnevali, Gary Hardiman
Ubiquitous exposure to bisphenol A (BPA), an endocrine disruptor (ED), has raised concerns for both human and ecosystem health. Epigenetic factors, including microRNAs (miRNAs), are key regulators of gene expression during cancer. The effect of BPA exposure on the zebrafish epigenome remains poorly characterized. Zebrafish represents an excellent model to study cancer as the organism develops a disease that resembles human cancer. Using zebrafish as a systems toxicology model, we hypothesized that chronic BPA-exposure impacts the miRNome in adult zebrafish and establishes an epigenome more susceptible to cancer development...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/29016128/acute-toxicity-teratogenic-and-estrogenic-effects-of-bisphenol-a-and-its-alternative-replacements-bisphenol-s-bisphenol-f-and-bisphenol-af-in-zebrafish-embryo-larvae
#5
John Moreman, Okhyun Lee, Maciej Trznadel, Arthur David, Tetsuhiro Kudoh, Charles R Tyler
Bisphenol A (BPA), a chemical incorporated into plastics and resins, has estrogenic activity and is associated with adverse health effects in humans and wildlife. Similarly structured BPA analogues are widely used but far less is known about their potential toxicity or estrogenic activity in vivo. We undertook the first comprehensive analysis on the toxicity and teratogenic effects of the bisphenols BPA, BPS, BPF, and BPAF in zebrafish embryo-larvae and an assessment on their estrogenic mechanisms in an estrogen-responsive transgenic fish Tg(ERE:Gal4ff)(UAS:GFP)...
November 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28992791/bisphenol-a-and-di-2-ethylhexyl-phthalate-exert-divergent-effects-on-apoptosis-and-the-wnt-%C3%AE-catenin-pathway-in-zebrafish-embryos-a-possible-mechanism-of-endocrine-disrupting-chemical-action
#6
Ünsal Veli Üstündağ, İsmail Ünal, Perihan Seda Ateş, A Ata Alturfan, Türkan Yiğitbaşı, Ebru Emekli-Alturfan
Polyethylene terephthalate (PET) and polycarbonate (PC) are the most commonly used plastics in water bottles. Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in PET plastics, and bisphenol A (BPA) is used to produce PC. Both DEHP and BPA are known for their potential endocrine disrupting effects. The Wnt/β-catenin signaling pathway has important roles in cell proliferation, cell specification and cell fate determination during embryonic development. Recent reports suggest a link between the Wnt/β-catenin signaling pathway and apoptosis...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28946120/bisphenol-s-exposure-impairs-glucose-homeostasis-in-male-zebrafish-danio-rerio
#7
Fei Zhao, Guobin Jiang, Penghao Wei, Hongfang Wang, Shaoguo Ru
Bisphenol S (BPS) is a substitute of the plastic additive bisphenol A (BPA). Its concentrations detected in surface waters and urine samples are on the same order of magnitude as BPA. Human exposure to BPA has been implicated in the development of diabetes mellitus; however, whether BPS can disrupt glucose homeostasis and increase blood glucose concentration remains unclear. We extensively investigated the effects of environmentally relevant concentrations of BPS on glucose metabolism in male zebrafish (Danio rerio) and the underlying mechanisms of these effects...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28943455/assaying-uptake-of-endocrine-disruptor-compounds-in-zebrafish-embryos-and-larvae
#8
J Paige Souder, Daniel A Gorelick
To study the effects of environmental endocrine disruptor compounds (EDCs) on aquatic animals, embryos and larvae are typically incubated in water containing defined concentrations of EDCs. However, the amount of EDC uptake into the animal is often difficult to determine. Using radiolabeled estradiol ([(3)H]E2), we previously developed a rapid, straightforward assay to measure estradiol uptake from water into zebrafish embryos and larvae. Here, we extend this approach to measure the uptake of two additional EDCs, bisphenol A (BPA) and ethinyl estradiol (EE2)...
September 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28793400/enhanced-uptake-of-bpa-in-the-presence-of-nanoplastics-can-lead-to-neurotoxic-effects-in-adult-zebrafish
#9
Qiqing Chen, Daqiang Yin, Yunlu Jia, Sabrina Schiwy, Jessica Legradi, Shouye Yang, Henner Hollert
Plastic particles have been proven to be abundant in the aquatic environment, raising concerns about their potential toxic effects. In the present study, we determined the bioaccumulation potential of bisphenol A (BPA) in adult zebrafish (Danio rerio) in the absence and presence of nano-sized plastic particles (nanoplastics, NPPs). Results show that BPA can accumulate in the viscera, gill, head and muscle of zebrafish with 85, 43, 20, and 3μg/g ww after 1d exposure. NPPs were also found to accumulate in different tissues of the fish...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28780062/metabolic-disruption-of-zebrafish-danio-rerio-embryos-by-bisphenol-a-an-integrated-metabolomic-and-transcriptomic-approach
#10
Elena Ortiz-Villanueva, Laia Navarro-Martín, Joaquim Jaumot, Fernando Benavente, Victoria Sanz-Nebot, Benjamín Piña, Romà Tauler
Although bisphenol A (BPA) is commonly recognized as an endocrine disruptor, the metabolic consequences of its exposure are still poorly understood. In this study, we present a non-targeted LC-MS based metabolomic analysis in combination with a full-genome, high-throughput RNA sequencing (RNA-Seq) to reveal the metabolic effects and the subjacent regulatory pathways of exposing zebrafish embryos to BPA during the first 120 hours post-fertilization. We applied multivariate data analysis methods to extract biochemical information from the LC-MS and RNA-Seq complex datasets and to perform testable predictions of the phenotypic adverse effects...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28765074/estrogenic-effects-associated-with-bisphenol-a-exposure-in-male-zebrafish-danio-rerio-is-associated-with-changes-of-endogenous-17%C3%AE-estradiol-and-gene-specific-dna-methylation-levels
#11
Fei Zhao, Penghao Wei, Jun Wang, Miao Yu, Xiaona Zhang, Hua Tian, Wei Wang, Shaoguo Ru
The binding affinity of bisphenol A (BPA) to estrogen receptors (ERs) is much lower than that of 17β-estradiol (E2), and whether there are other molecular mechanisms responsible for the estrogenic action of BPA in vivo currently remains unknown. The objective of this study was to explore the potential association between the estrogenic effect induced by bisphenol A in vivo and changes of endogenous E2 and gene specific DNA methylation levels. After a waterborne exposure of male zebrafish to 500, 1000, or 1500μg/L of BPA for 21d, vitellogenin (VTG) concentration in whole body homogenate, plasma E2 and testosterone levels, hepatic ERs mRNA expressions, gonadal cyp19a1a and cyp17a1 mRNA expressions, and methylation levels of hepatic esr1 and gonadal cyp19a1a's promoters were determined...
October 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28741210/effects-of-bpf-on-steroid-hormone-homeostasis-and-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis-of-zebrafish
#12
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish...
September 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28734242/environmental-estrogen-s-induced-swimming-behavioural-alterations-in-adult-zebrafish-danio-rerio
#13
Basavaraj B Goundadkar, Pancharatna Katti
The present study is an attempt to investigate the effects of long-term (75days) exposure to environmental estrogens (EE) on the swimming behaviour of zebrafish (Danio rerio). Adult zebrafish were exposed semi-statically to media containing commonly detected estrogenic water contaminants (EE2, DES and BPA) at a concentration (5ng/L) much lower than environmentally recorded levels. Time spent in swimming, surface preference, patterns and path of swimming were recorded (6mins) for each fish using two video cameras on day 15, 30 60 and 75...
July 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28551540/bisphenol-a-alternatives-in-thermal-paper-from-the-netherlands-spain-sweden-and-norway-screening-and-potential-toxicity
#14
Maria K Björnsdotter, Willem Jonker, Jessica Legradi, Jeroen Kool, Ana Ballesteros-Gómez
Thermal paper contains potentially toxic additives, such as bisphenol A (BPA), as a common color developer. Because of its known endocrine disrupting effects, structural analogues to BPA, such as bisphenol S (BPS), D-8 and Pergafast 201, have been used as alternatives, but little is known about the presence and toxicological effects of alternatives other than BPS. In this study, thermal paper is screened by direct probe ambient mass spectrometry (rapid pre-screening method not requiring sample preparation) and by liquid chromatography (LC) with high resolution time-of flight (TOF-MS) mass spectrometry...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28529144/toxicant-induced-behavioural-aberrations-in-larval-zebrafish-are-dependent-on-minor-methodological-alterations
#15
Thomas W K Fraser, Abdolrahman Khezri, Juan G H Jusdado, Anna M Lewandowska-Sabat, Theodore Henry, Erik Ropstad
Alterations in zebrafish motility are used to identify neurotoxic compounds, but few have reported how methodology may affect results. To investigate this, we exposed embryos to bisphenol A (BPA) or tetrabromobisphenol A (TBBPA) before assessing larval motility. Embryos were maintained on a day/night cycle (DN) or in constant darkness, were reared in 96 or 24 well plates (BPA only), and behavioural tests were carried out at 96, 100, or 118 (BPA only) hours post fertilisation (hpf). We found that the prior photo-regime, larval age, and/or arena size influence behavioural outcomes in response to toxicant exposure...
July 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28411468/nine-co-localized-cytochrome-p450-genes-of-the-cyp2n-cyp2ad-and-cyp2p-gene-families-in-the-mangrove-killifish-kryptolebias-marmoratus-genome-identification-and-expression-in-response-to-b-%C3%AE-p-bpa-op-and-np
#16
Jayesh Puthumana, Bo-Mi Kim, Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Jee-Hyun Jung, Il-Chan Kim, Un-Ki Hwang, Jae-Seong Lee
The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K...
June 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28407500/in-vitro-and-in-vivo-estrogenic-activity-of-bpa-bpf-and-bps-in-zebrafish-specific-assays
#17
Vincent Le Fol, Selim Aït-Aïssa, Manoj Sonavane, Jean-Marc Porcher, Patrick Balaguer, Jean-Pierre Cravedi, Daniel Zalko, François Brion
Bisphenol A (BPA) is a widely used chemical that has been extensively studied as an endocrine-disrupting chemical (EDC). Other bisphenols sharing close structural features with BPA, are increasingly being used as alternatives, increasing the need to assess associated hazards to the endocrine system. In the present study, the estrogenic activity of BPA, bisphenol S (BPS) and bisphenol F (BPF) was assessed by using a combination of zebrafish-specific mechanism-based in vitro and in vivo assays. The three bisphenols were found to efficiently transactivate all zebrafish estrogen receptor (zfER) subtypes in zebrafish hepatic reporter cell lines (ZELH-zfERs)...
August 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28080214/-1-h-nmr-based-metabolomic-studies-of-bisphenol-a-in-zebrafish-danio-rerio
#18
Changshin Yoon, Dahye Yoon, Junghee Cho, Siwon Kim, Heonho Lee, Hyeonsoo Choi, Suhkmann Kim
Proton nuclear magnetic resonance ((1)H-NMR) spectroscopy was used to study the response of zebrafish (Danio rerio) to increasing concentrations of bisphenol A (4,4'-(propane-2,2-diyl)diphenol, BPA). Orthogonal partial least squares discriminant analysis (OPLS-DA) was applied to detect aberrant metabolomic profiles after 72 h of BPA exposure at all levels tested (0.01, 0.1, and 1.0 mg/L). The OPLS-DA score plots showed that BPA exposure caused significant alterations in the metabolome. The metabolomic changes in response to BPA exposure generally exhibited nonlinear patterns, with the exception of reduced levels of several metabolites, including glutamine, inosine, lactate, and succinate...
April 3, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28007532/role-of-g-protein-coupled-estrogen-receptor-gper-gpr30-in-maintenance-of-meiotic-arrest-in-fish-oocytes
#19
REVIEW
Peter Thomas
An essential role for GPER (formerly known as GPR30) in regulating mammalian reproduction has not been identified to date, although it has shown to be involved in the regulation a broad range of other estrogen-dependent functions. In contrast, an important reproductive role for GPER in the maintenance of oocyte meiotic arrest has been identified in teleost fishes, which is briefly reviewed here. Recent studies have clearly shown that ovarian follicle production of estradiol-17β (E2) maintains meiotic arrest in several teleost species through activation of GPER coupled to a stimulatory G protein (Gs) on oocyte plasma membranes resulting in stimulation of cAMP production and maintenance of elevated cAMP levels...
March 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27880925/developmental-bisphenol-a-exposure-impairs-sperm-function-and-reproduction-in-zebrafish
#20
Jiangfei Chen, Katerine S Saili, Yueqin Liu, Lelin Li, Yuxin Zhao, Yinhang Jia, Chenglian Bai, Robert L Tanguay, Qiaoxiang Dong, Changjiang Huang
The developmental and reproductive toxicity of bisphenol A (BPA) has been demonstrated in a variety of model systems. Zebrafish (Danio rerio) were waterborne-exposed to BPA during three different developmental stages: embryonic period:6 h post fertilization (hpf) to 5 months post fertilization (mpf); larval period: 6 days post fertilization (dpf) to 5 mpf; and sexually mature period: 3 mpf to 5 mpf. Evaluations included F0 adult growth, reproduction parameters, and F1 offspring development. BPA exposure did not affect zebrafish growth in any of exposure groups...
February 2017: Chemosphere
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