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https://www.readbyqxmd.com/read/29782159/reduced-zebrafish-transcriptome-atlas-toward-understanding-the-environmental-neurotoxicants
#1
Kun Zhang, Yanbin Zhao
Transcriptomic approaches monitoring gene responses at genome-scale are increasingly used in toxicological research and help to clarify the molecular mechanisms of adverse effects caused by environmental toxicants. However, their applications for chemical assessment are hampered due to high expenses required and more importantly the lack of in-depth data mining and mechanistic perspectives. Here, we described a Reduced Transcriptome Atlas (RTA) approach which integrates transcriptomic datasets and a comprehensive panel of genes generated to represent neurogenesis and the early neuronal development of zebrafish, to determine the potential neurodevelopmental toxicities of environmental chemicals...
May 21, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29763311/thyroid-disruption-by-bisphenol-s-analogues-via-thyroid-hormone-receptor-%C3%AE-in-vitro-in-vivo-and-molecular-dynamics-simulation-study
#2
Liping Lu, Tingjie Zhan, Mei Ma, Chao Xu, Jingpeng Wang, Chunlong Zhang, Weiping Liu, Shulin Zhuang
Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as BPA alternatives. The global usage of BPS and its analogues (BPSs) caused the frequent detection of their residues in multiple environmental media. We investigated their potential endocrine disrupting effects toward thyroid hormone receptor (TR) β. The molecular interaction of BPSs toward TRβ ligand binding domain (LBD) was probed by fluorescence spectroscopy and molecular dynamics (MD) simulations. BPSs caused the static fluorescence quenching of TRβ LBD...
May 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29738667/estrogenic-mechanisms-and-cardiac-responses-following-early-life-exposure-to-bisphenol-a-bpa-and-its-metabolite-4-methyl-2-4-bis-p-hydroxyphenyl-pent-1-ene-mbp-in-zebrafish
#3
John Moreman, Aya Takesono, Maciej Trznadel, Matthew Winter, Alexis Perry, Mark Wood, Nicola Jane Rogers, Tetsuhiro Kudoh, Charles R Tyler
Environmental exposure to Bisphenol A (BPA) has been associated with a range of adverse health effects, including on the cardiovascular system in humans. Lack of agreement on its mechanism(s) of action likely stem from comparisons between in vivo and in vitro test systems and potential multiple effects pathways. In rodents, in vivo, metabolic activation of BPA produces 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), which is reported to be up to 1000 times more potent as an estrogen than BPA. We investigated the estrogenic effects and estrogen receptor signaling pathway(s) of BPA and MBP following early life exposure using a transgenic, estrogen responsive (ERE-TG) zebrafish and a targeted morpholino approach to knockdown the three fish estrogen receptor (ER) subtypes...
May 8, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29723837/effects-of-diethylene-glycol-dibenzoate-and-bisphenol-a-on-the-lipid-metabolism-of-danio-rerio
#4
Stefania Santangeli, Valentina Notarstefano, Francesca Maradonna, Elisabetta Giorgini, Giorgia Gioacchini, Isabel Forner-Piquer, Hamid R Habibi, Oliana Carnevali
Endocrine disrupting chemicals (EDCs) are known to disrupt normal metabolism and can influence the incidence of obesity in animals and humans. EDCs can exert adverse effects at low concentrations, often in a non-monotonic dose-related fashion. Among EDCs, Bisphenol A (BPA) is extensively used in the production of polycarbonate plastic, and is among the most abundant contaminants in the world. Diethylene glycol dibenzoate (DGB), an approved alternative to phthalates in the production of plastic and latex products, however, is less abundant and its effects are almost completely unknown...
April 30, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29689525/role-of-bisphenol-a-on-the-endocannabinoid-system-at-central-and-peripheral-levels-effects-on-adult-female-zebrafish
#5
Isabel Forner-Piquer, Stefania Santangeli, Francesca Maradonna, Roberta Verde, Fabiana Piscitelli, Vincenzo di Marzo, Hamid R Habibi, Oliana Carnevali
Bisphenol A (BPA), a widely used chemical to produce polycarbonate plastics, has become an ubiquitous pollutant due to its extensive use. Its endocrine disrupting properties have been documented in several studies, as well as its potential to induce metabolic and reproductive impairments at environmentally relevant concentrations. Recent insights highlighted the role of the Endocannabinoid System (ECS) in energy homeostasis and lipid metabolism. In fact, disruption of the ECS may induce metabolic alterations among other effects...
August 2018: Chemosphere
https://www.readbyqxmd.com/read/29660719/assessment-of-endocrine-disruptors-effects-on-zebrafish-danio-rerio-embryos-by-untargeted-lc-hrms-metabolomic-analysis
#6
Elena Ortiz-Villanueva, Joaquim Jaumot, Rubén Martínez, Laia Navarro-Martín, Benjamin Piña, Romà Tauler
Bisphenol A (BPA), perfluorooctane sulfonate (PFOS), and tributyltin (TBT) are emerging endocrine disruptors (EDCs) with still poorly defined mechanisms of toxicity and metabolic effects in aquatic organisms. We used an untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomic approach to study the effects of sub-lethal doses of these three EDCs on the metabolic profiles of zebrafish embryos exposed from 48 to 120hpf (hours post fertilization). Advanced chemometric data analysis methods were used to reveal effects on the subjacent regulatory pathways...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29559645/modeling-environmentally-induced-motor-neuron-degeneration-in-zebrafish
#7
Jessica R Morrice, Cheryl Y Gregory-Evans, Christopher A Shaw
Zebrafish have been used to investigate motor neuron degeneration, including as a model system to examine the pathogenesis of amyotrophic lateral sclerosis (ALS). The use of zebrafish for this purpose has some advantages over other in vivo model systems. In the current paper, we show that bisphenol A (BPA) exposure in zebrafish embryos results in motor neuron degeneration with affected motor function, reduced motor axon length and branching, reduced neuromuscular junction integrity, motor neuron cell death and the presence of activated microglia...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29549734/hypothalamic-pituitary-ovarian-axis-perturbation-in-the-basis-of-bisphenol-a-bpa-reproductive-toxicity-in-female-zebrafish-danio-rerio
#8
Ana Molina, Nieves Abril, Noelia Morales-Prieto, José Monterde, Nahúm Ayala, Antonio Lora, Rosario Moyano
Thousands of safety-related studies have been published on bisphenol A (BPA), an ubiquitous environmental pollutant with estrogenic activity and many other potential biological effects. In recent years, BPA exposure has been shown to cause anovulation and infertility through irreversible alteration of the hypothalamic-pituitary-gonadal axis in several organisms, including fish and mammals. Recently, the European Chemical Agency classified BPA as a "substance of very high concern" because of its endocrine-disrupting properties, which have serious effects on human health...
July 30, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29454160/vascular-parameters-continue-to-decrease-post-exposure-with-simultaneous-but-not-individual-exposure-to-bpa-and-hypoxia-in-zebrafish-larvae
#9
Alysha D Cypher, Bryce Fetterman, Brian Bagatto
How fish respond to hypoxia, a common stressor, can be altered by simultaneous exposure to pollutants like bisphenol A (BPA), a plasticizer. BPA is cardiotoxic and interferes with the hypoxia inducible factor pathway (HIF-1α), therefore disrupting the hypoxic response. Co-exposure to hypoxia and BPA also causes severe bradycardia and reduced cardiac output in zebrafish larvae. The purpose of this work was to determine how the cardiovascular effects of co-exposure vary with BPA concentration and persist beyond exposure...
April 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29409039/the-affinity-of-brominated-phenolic-compounds-for-human-and-zebrafish-thyroid-receptor-%C3%AE-influence-of-chemical-structure
#10
Erin M Kollitz, Lauren De Carbonnel, Heather M Stapleton, P Lee Ferguson
Brominated phenolic compound (BPCs) are found in the environment, and in human and wildlife tissues, and some are considered to have endocrine disrupting activities. The goal of this study was to determine how structural differences of three BPC classes impact binding affinities for the thyroid receptor beta (TRβ) in humans and zebrafish. BPC classes included halogenated bisphenol A (BPA) derivatives, halogenated oxidative transformation products of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), and brominated phenols...
February 2, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29397701/developmental-effects-and-estrogenicity-of-bisphenol-a-alternatives-in-a-zebrafish-embryo-model
#11
Xiyan Mu, Ying Huang, Xuxing Li, Yunlei Lei, Miaomiao Teng, Xuefeng Li, Chengju Wang, Yingren Li
In order to understand the negative effects of bisphenol A (BPA) alternatives comprehensively, zebrafish embryos were used to assess the lethality, developmental effects, and estrogenic activity of bisphenol analogues. The in silico estrogenic activities of bisphenol analogues were assayed by binding simulation. According to our results, the lethality of bisphenol analogues decreased in order of bisphenol AF (BPAF) > BPA > bisphenol F (BPF) > bisphenol S (BPS). BPAF and BPF induced significant effects on zebrafish embryos, including decreased heart rate, hatching inhibition, and teratogenic effects...
March 6, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29258955/evaluation-of-toxicological-endpoints-in-female-zebrafish-after-bisphenol-a-exposure
#12
Ana M Molina, Nieves Abril, Noelia Morales-Prieto, José G Monterde, Antonio J Lora, Nahúm Ayala, Rosario Moyano
Given the importance of bisphenol A (BPA) as a xenoestrogen and its potential effects on human and animal health, we evaluated BPA exposure's short-term effects on follicular development, yolk protein vitellogenin (VTG) production and aromatase expression in female zebrafish. Histological modifications were observed along with increased presence of atretic follicles. Whole-body VTG concentration increased with the dose of BPA exposure. In contrast, expression of Cyp19a mRNA in the ovaries of BPA-exposed fish exhibited an apparent non-monotonic response curve, marked by downregulation at 1 μg/L BPA, upregulation at 10 μg/L BPA, and a return to downregulation at 100 μg/L BPA and higher doses...
February 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29241697/opening-the-black-box-of-endocrine-disruption-of-brain-development-lessons-from-the-characterization-of-bisphenol-a
#13
REVIEW
Dinushan Nesan, Laronna C Sewell, Deborah M Kurrasch
Bisphenol A (BPA) is among the best-studied endocrine disrupting chemicals, known to act via multiple steroid hormone receptors to mediate a myriad of cellular effects. Pre-, peri-, and postnatal BPA exposure have been linked to a variety of altered behaviors in multiple model organisms, ranging from zebrafish to frogs to mammalian models. Given that BPA can cross the human placental barrier and has been found in the serum of human fetuses during gestation, BPA has been postulated to adversely affect ongoing neurodevelopment, ultimately leading to behavioral disorders later in life...
January 3, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29224359/a-reduced-transcriptome-approach-to-assess-environmental-toxicants-using-zebrafish-embryo-test
#14
Pingping Wang, Pu Xia, Jianghua Yang, Zhihao Wang, Ying Peng, Wei Shi, Daniel L Villeneuve, Hongxia Yu, Xiaowei Zhang
Omics approaches can monitor responses and alterations of biological pathways at genome-scale, which are useful to predict potential adverse effects by environmental toxicants. However, high throughput application of transcriptomics in chemical assessment is limited due to the high cost and lack of "standardized" toxicogenomic methods. Here, a reduced zebrafish transcriptome (RZT) approach was developed to represent the whole transcriptome and to profile bioactivity of chemical and environmental mixtures in zebrafish embryo...
January 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29199129/evaluating-estrogenic-and-anti-estrogenic-effect-of-endocrine-disrupting-chemicals-edcs-by-zebrafish-danio-rerio-embryo-based-vitellogenin-1-vtg1-mrna-expression
#15
Minjie Chen, Jie Zhang, Shaochen Pang, Chang Wang, Ling Wang, Yonghua Sun, Maoyong Song, Yong Liang
By measuring the vitellogenin 1 (vtg1) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17β-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect of the tested chemicals was ranked as: DES>E2 >E3 >OP>BPA, which is consistent with various in vivo and in vitro models...
January 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29195089/immunotoxicity-of-bisphenol-s-and-f-are-similar-to-that-of-bisphenol-a-during-zebrafish-early-development
#16
Wenhui Qiu, Haiyang Shao, Penghui Lei, Chunmiao Zheng, Cunxin Qiu, Ming Yang, Yi Zheng
Bisphenol S (BPS) and bisphenol F (BPF) have been increasingly used as alternatives to bisphenol A (BPA) owing to health concerns. The present study aims to evaluate the impact of these two BPA analogs on oxidative stress and the immune system during zebrafish embryonic and larval development. Environmentally relevant levels of BPS and BPF exposure could increase reactive oxygen species (ROS) content, nitric oxide (NO) content, nitric oxide synthase (NOS) activity, and the expression of immunity-related genes in concentration dependent manners during the early developmental stages in zebrafish...
March 2018: Chemosphere
https://www.readbyqxmd.com/read/29190539/dysbiosis-of-gut-microbiota-by-chronic-coexposure-to-titanium-dioxide-nanoparticles-and-bisphenol-a-implications-for-host-health-in-zebrafish
#17
Lianguo Chen, Yongyong Guo, Chenyan Hu, Paul K S Lam, James C W Lam, Bingsheng Zhou
Gut microbiota is of critical relevance to host health. However, toxicological understanding of environmental pollutants on gut microbiota is limited, not to mention their combined effects. In the present study, adult zebrafish (Danio rerio) were exposed to titanium dioxide nanoparticles (nano-TiO2 ; 100 μg/L), bisphenol A (BPA; 0, 2, and 20 μg/L) or their binary mixtures for three months. Sequencing of 16S rRNA amplicons found that nano-TiO2 and BPA coexposure shifted the intestinal microbial community, interacting in an antagonistic manner when the BPA concentration was low but in a synergistic manner at a higher BPA concentration...
March 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29145093/proteomic-profile-and-toxicity-pathway-analysis-in-zebrafish-embryos-exposed-to-bisphenol-a-and-di-n-butyl-phthalate-at-environmentally-relevant-levels
#18
Xing Dong, Xuchun Qiu, Shunlong Meng, Hai Xu, Xiangyang Wu, Ming Yang
Bisphenol A (BPA) and di-n-butyl phthalate (DBP) are well-known endocrine-disrupting chemicals (EDCs) that have human health risks. Chronic exposure to BPA and DBP increases the occurrence of human disease. Despite the potential for exposure in embryonic development, the mechanism of action of BPA and DBP on vertebrate development and disease still remains unclear. In the present study, we identified proteins and protein networks that are perturbed by BPA and DBP during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to environmentally relevant levels of BPA (10 μg/L) and DBP (50 μg/L) for 96 h...
February 2018: Chemosphere
https://www.readbyqxmd.com/read/29102625/reprint-of-role-of-g-protein-coupled-estrogen-receptor-gper-gpr30-in-maintenance-of-meiotic-arrest-in-fish-oocytes
#19
REVIEW
Peter Thomas
An essential role for GPER (formerly known as GPR30) in regulating mammalian reproduction has not been identified to date, although it has shown to be involved in the regulation a broad range of other estrogen-dependent functions. In contrast, an important reproductive role for GPER in the maintenance of oocyte meiotic arrest has been identified in teleost fishes, which is briefly reviewed here. Recent studies have clearly shown that ovarian follicle production of estradiol-17β (E2 ) maintains meiotic arrest in several teleost species through activation of GPER coupled to a stimulatory G protein (Gs ) on oocyte plasma membranes, resulting in stimulation of cAMP production and maintenance of elevated cAMP levels...
February 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29055862/juvenile-exposure-to-bisphenol-a-promotes-ovarian-differentiation-but-suppresses-its-growth-potential-involvement-of-pituitary-follicle-stimulating-hormone
#20
Weiting Chen, Shuk-Wa Lau, Yuqin Fan, Rudolf S S Wu, Wei Ge
Bisphenol A (BPA), a plastic monomer and plasticizer, is commonly used in plastics industry, and it has been well documented to be an estrogenic endocrine disrupter. In the present study, we investigated the effect of early (juvenile) exposure to BPA on the hypothalamic-pituitary-gonad (HPG) axis in the zebrafish. Estradiol (E2) and testosterone (T) were also included as positive and negative controls respectively. Juvenile zebrafish were exposed to BPA (1 and 10μM), E2 (10nM) and T (10nM) from 20 to 40 dpf (days post-fertilization), the period of sex/gonadal differentiation, followed by histological and expression analyses at 40 dpf...
December 2017: Aquatic Toxicology
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