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Zebrafish bpa

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https://www.readbyqxmd.com/read/27880925/developmental-bisphenol-a-exposure-impairs-sperm-function-and-reproduction-in-zebrafish
#1
Jiangfei Chen, Katerine S Saili, Yueqin Liu, Lelin Li, Yuxin Zhao, Yinhang Jia, Chenglian Bai, Robert L Tanguay, Qiaoxiang Dong, Changjiang Huang
The developmental and reproductive toxicity of bisphenol A (BPA) has been demonstrated in a variety of model systems. Zebrafish (Danio rerio) were waterborne-exposed to BPA during three different developmental stages: embryonic period:6 h post fertilization (hpf) to 5 months post fertilization (mpf); larval period: 6 days post fertilization (dpf) to 5 mpf; and sexually mature period: 3 mpf to 5 mpf. Evaluations included F0 adult growth, reproduction parameters, and F1 offspring development. BPA exposure did not affect zebrafish growth in any of exposure groups...
November 20, 2016: Chemosphere
https://www.readbyqxmd.com/read/27855330/behavioural-effect-of-low-dose-bpa-on-male-zebrafish-tuning-of-male-mating-competition-and-female-mating-preference-during-courtship-process
#2
Xiang Li, Jia-Yu Guo, Xu Li, Hai-Jun Zhou, Shu-Hui Zhang, Xiao-Dong Liu, Dong-Yan Chen, Yong-Chun Fang, Xi-Zeng Feng
The ubiquity of environmental pollution by endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) is progressively considered as a major threat to aquatic ecosystems worldwide. Numerous toxicological studies have proved that BPA are hazardous to aquatic environment, along with alterations in the development and physiology of aquatic vertebrates. However, generally, there is a paucity in knowledge of behavioural and physiological effects of BPA with low concentration, for example, 0.22 nM (50 ng/L) and 2...
November 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27771541/comparison-of-different-advanced-treatment-processes-in-removing-endocrine-disruption-effects-from-municipal-wastewater-secondary-effluent
#3
Jie Sun, Jing Wang, Rui Zhang, Dongyang Wei, Qin Long, Yu Huang, Xianchuan Xie, Aimin Li
In this study, secondary effluent from the Wulongkou (WLK) municipal wastewater plant (Zhengzhou, China) was tested for its toxicity effects before and after five advanced treatment processes (ATPs, i.e. coagulation sedimentation, nan da magnetic polyacrylic anion exchange resin (NDMP) resin adsorption, activated carbon adsorption, ozonation and electro-adsorption). Results showed that estrogen disruption effects (EDEs) were particularly significant for the raw secondary effluent among the studied dioxin-like toxicity effect, androgenic/anti-androgenic response effect, EDEs, and genotoxicity effect...
October 20, 2016: Chemosphere
https://www.readbyqxmd.com/read/27701432/influence-of-endogenous-and-exogenous-estrogenic-endocrine-on-intestinal-microbiota-in-zebrafish
#4
Yukun Liu, Yayun Yao, Huan Li, Fang Qiao, Junlin Wu, Zhen-Yu Du, Meiling Zhang
Gender is one of the factors influencing the intestinal microbial composition in mammals, but whether fish also have gender-specific intestinal microbial patterns remains unknown. In this decade, endocrine disrupting chemicals in surface and ground water of many areas and increasing observation of freshwater male fish displaying female sexual characteristics have been reported. Here we identified the difference in intestinal microbiota between male and female zebrafish, and revealed the influence of endocrine disrupting chemicals on zebrafish intestinal microbiota by using high-throughput sequencing...
2016: PloS One
https://www.readbyqxmd.com/read/27486708/screening-of-toxic-effects-of-bisphenol-a-and-products-of-its-degradation-zebrafish-danio-rerio-embryo-test-and-molecular-docking
#5
Katerina Makarova, Pawel Siudem, Katarzyna Zawada, Justyna Kurkowiak
Bisphenol A (BPA) acts as an endocrine-disrupting compound even at a low concentration. Degradation of BPA could lead to the formation of toxic products. In this study, we compare the toxicity of BPA and seven intermediate products of its degradation. The accuracy of three molecular docking programs (Surflex, Autodock, and Autodock Vina) in predicting the binding affinities of selected compounds to human (ERα, ERβ, and ERRγ) and zebrafish (ERα, ERRγA, and ERRγB) estrogen and estrogen-related receptors was evaluated...
October 2016: Zebrafish
https://www.readbyqxmd.com/read/27362491/uptake-depuration-and-bioconcentration-of-bisphenol-af-bpaf-in-whole-body-and-tissues-of-zebrafish-danio-rerio
#6
Jiachen Shi, Yunjia Yang, Jing Zhang, Yixing Feng, Bing Shao
Bisphenol AF (BPAF) is an analog of Bisphenol A (BPA) and is widely used as a raw material in the plastics industry. However, an understanding of the potential risks posed by BPAF in the aquatic environment is lacking. The bioconcentration factor (BCF) is a measure used to assess the secondary poisoning potential as well as risks to human health. In this work we measured the accumulation and elimination of BPAF in the whole-body and in liver, muscle and gonad tissues of zebrafish. BPAF uptake was relatively rapid with equilibrium concentrations reached after 24-72h of exposure...
October 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27314163/efficacy-of-uv-c-photolysis-of-bisphenol-a-on-transcriptome-alterations-of-genes-in-zebrafish-embryos
#7
Asma Saeed, Imran Hashmi, Ava Zare, Mitra Mehrabani-Zeinabad, Gopal Achari, Hamid R Habibi
The purpose of this study was to investigate the efficacy of UV-C direct photolysis of bisphenol A (BPA) as a remediation method of BPA contamination. We used zebrafish embryos as a model organism to test the toxicity and residual biological activity by measuring cytochrome P4501A1 (CYP1A), aromatase B (Aro B) and heat shock proteins (HSP-70) transcript levels. The mRNA levels of CYP1A gene increased about two fold while exposure of zebrafish embryos at 72 hpf resulted in significant induction (P = 0.048) of Aro B at 100 µg/L of BPA...
September 18, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27231882/endocrine-disrupting-compounds-reduction-and-water-quality-improvement-in-reclaimed-municipal-wastewater-a-field-scale-study-along-jialu-river-in-north-china
#8
Jie Sun, Xiaowen Ji, Rui Zhang, Yu Huang, Ying Liang, Jinhui Du, Xianchuan Xie, Aimin Li
Several ecological restoration projects have been constructed along urban rivers in North China to purify reclaimed municipal wastewater and improve the water quality of urban rivers. These projects attempt to address several environmental issues, including treating water contamination that is not fully remediated through standard wastewater treatment. This study investigated the efficiency of reducing endocrine disrupting compounds (EDCs) and estrogenic activity in reclaimed municipal wastewater along an 18...
August 2016: Chemosphere
https://www.readbyqxmd.com/read/27156127/differential-recruitment-of-co-regulatory-proteins-to-the-human-estrogen-receptor-1-in-response-to-xenoestrogens
#9
L Cody Smith, Jessica C Clark, Joseph H Bisesi, P Lee Ferguson, Tara Sabo-Attwood
The diverse biological effects of xenoestrogens may be explained by their ability to differentially recruit co-regulatory proteins to the estrogen receptor (ER). We employed high-throughput receptor affinity binding and co-regulatory protein recruitment screening assays based on fluorescence polarization and time resolved florescence resonance energy transfer (TR-FRET), respectively, to assess xenoestrogen-specific binding and co-regulatory protein recruitment to the ER. Then we used a functional proteomic assay based on co-immunoprecipitation of ER-bound proteins to isolate and identify intact co-regulatory proteins recruited to a ligand-activated ER...
September 2016: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/27153368/kinetic-determination-of-vitellogenin-induction-in-the-epidermis-of-cyprinid-and-perciform-fishes-evaluation-of-sensitive-enzyme-linked-immunosorbent-assays
#10
Bernhard Allner, Mark Hennies, Cristiano F Lerche, Thomas Schmidt, Klaus Schneider, Marco Willner, Petra Stahlschmidt-Allner
Induction of vitellogenin (VTG) in male and immature fish is a standardized endpoint in endocrine-disruption testing. To establish a nondestructive swab sampling method, VTG induction in the epidermis of Cypriniformes and Perciformes species was investigated. Both VTG and estrogen receptor genes are expressed in epidermal cells. Immunoaffinity and mass fingerprint analyses show induction of identical VTG peptides in liver and epidermis. Induction of VTG by estradiol (E2) and bisphenol A (BPA) in the epidermis was quantified with homolog enzyme-linked immunosorbent assays...
May 6, 2016: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/27120497/bisphenol-a-causes-reproductive-toxicity-decreases-dnmt1-transcription-and-reduces-global-dna-methylation-in-breeding-zebrafish-danio-rerio
#11
L V Laing, J Viana, E L Dempster, M Trznadel, L A Trunkfield, T M Uren Webster, R van Aerle, G C Paull, R J Wilson, J Mill, E M Santos
Bisphenol A (BPA) is a commercially important high production chemical widely used in epoxy resins and polycarbonate plastics, and is ubiquitous in the environment. Previous studies demonstrated that BPA activates estrogenic signaling pathways associated with adverse effects on reproduction in vertebrates and that exposure can induce epigenetic changes. We aimed to investigate the reproductive effects of BPA in a fish model and to document its mechanisms of toxicity. We exposed breeding groups of zebrafish (Danio rerio) to 0...
July 2, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27107150/adverse-morphological-development-in-embryonic-zebrafish-exposed-to-environmental-concentrations-of-contaminants-individually-and-in-mixture
#12
Cassandra D Kinch, Deborah M Kurrasch, Hamid R Habibi
Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders. In addition, there is evidence linking environmental contaminants and endocrine disruption to abnormal developmental rate, defects in heart and eye morphology, and alterations in behavior. Notably, these effects could not be explained by interaction with a single hormone receptor. Here, using a whole-organism approach, we investigated morphological changes to developing zebrafish caused by exposure to a number of environmental contaminants, including bisphenol A (BPA), di(2-ethylhexyl)phthalate (DEHP), nonylphenol, and fucosterol at concentrations measured in a local water body (Oldman River, AB), individually and in mixture...
June 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/27101439/global-dna-methylation-in-gonads-of-adult-zebrafish-danio-rerio-under-bisphenol-a-exposure
#13
Yan Liu, Yingying Zhang, Shiyu Tao, Yongjing Guan, Ting Zhang, Zaizhao Wang
Altered DNA methylation is pervasively associated with changes in gene expression and signal transduction after exposure to a wide range of endocrine disrupting chemicals. As a weak estrogenic chemical, bisphenol A (BPA) has been extensively studied for reproductive toxicity. In order to explore the effects of BPA on epigenetic modification in gonads of zebrafish Danio rerio, we measured the global DNA methylation together with the gene expression of DNA methyltransferase (dnmts), glycine N-methyltransferase (gnmt), and ten-eleven translocation (tets) in gonads of D...
August 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27047331/estrogenic-effects-of-several-bpa-analogs-in-the-developing-zebrafish-brain
#14
Joel Cano-Nicolau, Colette Vaillant, Elisabeth Pellegrini, Thierry D Charlier, Olivier Kah, Pascal Coumailleau
Important set of studies have demonstrated the endocrine disrupting activity of Bisphenol A (BPA). The present work aimed at defining estrogenic-like activity of several BPA structural analogs, including BPS, BPF, BPAF, and BPAP, on 4- or 7-day post-fertilization (dpf) zebrafish larva as an in vivo model. We measured the induction level of the estrogen-sensitive marker cyp19a1b gene (Aromatase B), expressed in the brain, using three different in situ/in vivo strategies: (1) Quantification of cyp19a1b transcripts using RT-qPCR in wild type 7-dpf larva brains exposed to bisphenols; (2) Detection and distribution of cyp19a1b transcripts using in situ hybridization on 7-dpf brain sections (hypothalamus); and (3) Quantification of the cyp19a1b promoter activity in live cyp19a1b-GFP transgenic zebrafish (EASZY assay) at 4-dpf larval stage...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27014939/bisphenol-a-induces-fatty-liver-by-an-endocannabinoid-mediated-positive-feedback-loop
#15
Andrea Martella, Cristoforo Silvestri, Francesca Maradonna, Giorgia Gioacchini, Marco Allarà, Giuseppe Radaelli, Darryl R Overby, Vincenzo Di Marzo, Oliana Carnevali
The xenoestrogen bisphenol A (BPA) is a widespread plasticizer detectable within several ecosystems. BPA is considered a metabolic disruptor, affecting different organs; however, little is known about its mechanism of action in the liver, in which it triggers triglyceride accumulation. Adult zebrafish (Danio rerio) exposed to BPA developed hepatosteatosis, which was associated with an increase in the liver levels of the obesogenic endocannabinoids 2-arachidonoylglycerol and anandamide and a concomitant decrease in palmitoylethanolamide...
May 2016: Endocrinology
https://www.readbyqxmd.com/read/26994444/bis-gma-affects-craniofacial-development-in-zebrafish-embryos-danio-rerio
#16
Alexander G Kramer, Jompobe Vuthiganon, Christopher S Lassiter
Estrogen is a steroid hormone that is vital in vertebrate development and plays a role in a variety of developmental processes including cartilage and craniofacial formation. The effects of estrogen can be mimicked by other compounds found in the environment known as xenoestrogens. Bisphenol-A (BPA) is a known xenoestrogen and is combined with glycidyl methacrylate to make Bisphenol A glycidyl methacrylate (Bis-GMA), a major component in dental resin based composites (RBCs). Bis-GMA based RBCs can release their components into the saliva and bloodstream...
April 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/26957022/hazard-identification-and-risk-characterization-of-bisphenols-a-f-and-af-to-aquatic-organisms
#17
Tatjana Tišler, Alja Krel, Urška Gerželj, Boštjan Erjavec, Marija Sollner Dolenc, Albin Pintar
Production of bisphenol A (BPA) analogues such as bisphenol F (BPF) and bisphenol AF (BPAF) has recently increased, due to clear evidence of adverse effects of BPA on humans and wildlife. Bisphenols (BPs) have already been released into aquatic environment without previous available information about potential adverse effects of BPs and their potential risk to aquatic ecosystems. In this study, lethal and sublethal effects of BPF and BPAF to bacteria, algae, crustacea and fish embryos were investigated and the results were compared to the adverse effects obtained for BPA...
May 2016: Environmental Pollution
https://www.readbyqxmd.com/read/26911650/bpa-induced-deregulation-of-epigenetic-patterns-effects-on-female-zebrafish-reproduction
#18
Stefania Santangeli, Francesca Maradonna, Giorgia Gioacchini, Gilda Cobellis, Chiara Carla Piccinetti, Luisa Dalla Valle, Oliana Carnevali
Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related to reproduction are caused by histone modifications, BPA concentrations consistent with environmental exposure were administered to zebrafish for three weeks. Effects on oocyte growth and maturation, autophagy and apoptosis processes, histone modifications, and DNA methylation were assessed by Real-Time PCR (qPCR), histology, and chromatin immunoprecipitation combined with qPCR analysis (ChIP-qPCR)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26712470/zebrafish-embryos-as-a-screen-for-dna-methylation-modifications-after-compound-exposure
#19
Manon C Bouwmeester, Sander Ruiter, Tobias Lommelaars, Josefine Sippel, Hennie M Hodemaekers, Evert-Jan van den Brandhof, Jeroen L A Pennings, Jorke H Kamstra, Jaroslav Jelinek, Jean-Pierre J Issa, Juliette Legler, Leo T M van der Ven
Modified epigenetic programming early in life is proposed to underlie the development of an adverse adult phenotype, known as the Developmental Origins of Health and Disease (DOHaD) concept. Several environmental contaminants have been implicated as modifying factors of the developing epigenome. This underlines the need to investigate this newly recognized toxicological risk and systematically screen for the epigenome modifying potential of compounds. In this study, we examined the applicability of the zebrafish embryo as a screening model for DNA methylation modifications...
January 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26694738/enhanced-bioconcentration-of-bisphenol-a-in-the-presence-of-nano-tio2-can-lead-to-adverse-reproductive-outcomes-in-zebrafish
#20
Qi Fang, Qipeng Shi, Yongyong Guo, Jianghuan Hua, Xianfeng Wang, Bingsheng Zhou
Titanium dioxide nanoparticles (n-TiO2) and bisphenol A (BPA) are widespread environmental contaminants in the aquatic environment. We hypothesized that n-TiO2 may adsorb BPA, and thus modify its bioavailability and toxicity to aquatic organisms. In this study, the bioavailability and toxicity of BPA (0, 2, 20, 200 μg/L) was investigated in the presence of n-TiO2 (100 μg/L). The n-TiO2 sorbed BPA and the resulting nanoparticles were taken up by zebrafish, where they translocated to the liver, brain, and gonad tissues...
January 19, 2016: Environmental Science & Technology
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