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Zebrafish fitness

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https://www.readbyqxmd.com/read/29197232/uptake-tissue-distribution-and-toxicity-of-polystyrene-nanoparticles-in-developing-zebrafish-danio-rerio
#1
Jordan A Pitt, Jordan S Kozal, Nishad Jayasundara, Andrey Massarsky, Rafael Trevisan, Nick Geitner, Mark Wiesner, Edward D Levin, Richard T Di Giulio
Plastic pollution is a critical environmental concern and comprises the majority of anthropogenic debris in the ocean, including macro, micro, and likely nanoscale (less than 100nm in at least one dimension) plastic particles. While the toxicity of macroplastics and microplastics is relatively well studied, the toxicity of nanoplastics is largely uncharacterized. Here, fluorescent polystyrene nanoparticles (PS NPs) were used to investigate the potential toxicity of nanoplastics in developing zebrafish (Danio rerio), as well as to characterize the uptake and distribution of the particles within embryos and larvae...
November 24, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29162049/rna-seq-and-tn-seq-reveal-fitness-determinants-of-vancomycin-resistant-enterococcus-faecium-during-growth-in-human-serum
#2
Xinglin Zhang, Vincent de Maat, Ana M Guzmán Prieto, Tomasz K Prajsnar, Jumamurat R Bayjanov, Mark de Been, Malbert R C Rogers, Marc J M Bonten, Stéphane Mesnage, Rob J L Willems, Willem van Schaik
BACKGROUND: The Gram-positive bacterium Enterococcus faecium is a commensal of the human gastrointestinal tract and a frequent cause of bloodstream infections in hospitalized patients. The mechanisms by which E. faecium can survive and grow in blood during an infection have not yet been characterized. Here, we identify genes that contribute to growth of E. faecium in human serum through transcriptome profiling (RNA-seq) and a high-throughput transposon mutant library sequencing approach (Tn-seq)...
November 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29145436/scrambled-eggs-proteomic-portraits-and-novel-biomarkers-of-egg-quality-in-zebrafish-danio-rerio
#3
Ozlem Yilmaz, Amélie Patinote, Thao Vi Nguyen, Emmanuelle Com, Regis Lavigne, Charles Pineau, Craig V Sullivan, Julien Bobe
Egg quality is a complex biological trait and a major determinant of reproductive fitness in all animals. This study delivered the first proteomic portraits of egg quality in zebrafish, a leading biomedical model for early development. Egg batches of good and poor quality, evidenced by embryo survival for 24 h, were sampled immediately after spawning and used to create pooled or replicated sample sets whose protein extracts were subjected to different levels of fractionation before liquid chromatography and tandem mass spectrometry...
2017: PloS One
https://www.readbyqxmd.com/read/29125897/image-analysis-of-neural-stem-cell-division-patterns-in-the-zebrafish-brain
#4
Valerio Lupperger, Felix Buggenthin, Prisca Chapouton, Carsten Marr
Proliferating stem cells in the adult body are the source of constant regeneration. In the brain, neural stem cells (NSCs) divide to maintain the stem cell population and generate neural progenitor cells that eventually replenish mature neurons and glial cells. How much spatial coordination of NSC division and differentiation is present in a functional brain is an open question. To quantify the patterns of stem cell divisions, one has to (i) identify the pool of NSCs that have the ability to divide, (ii) determine NSCs that divide within a given time window, and (iii) analyze the degree of spatial coordination...
November 10, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29035725/alterations-to-juvenile-zebrafish-danio-rerio-swim-performance-after-acute-embryonic-exposure-to-sub-lethal-exposures-of-hydraulic-fracturing-flowback-and-produced-water
#5
Erik J Folkerts, Tamzin A Blewett, Yuhe He, Greg G Goss
Hydraulic fracturing flowback and produced water (FPW) is a wastewater produced during fracturing activities in an operating well which is hyper saline and chemically heterogeneous in nature, containing both anthropogenic and petrogenic chemicals. Determination of FPW associated toxicity to embryonic fish is limited, while investigation into how embryonic exposures may affect later life stages is not yet studied. Zebrafish embryos (24hrs post fertilization) were acutely exposed to 2.5% and 5% FPW fractions for either 24 or 48hrs and returned to freshwater...
October 7, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29017090/combinatory-effects-of-low-concentrations-of-17%C3%AE-etinylestradiol-and-citalopram-on-non-reproductive-behavior-in-adult-zebrafish-danio-rerio
#6
Tove Porseryd, Martin Kellner, Nasim Reyhanian Caspillo, Kristina Volkova, Lubna Elabbas, Shahid Ullah, Håkan Olsén, Patrik Dinnétz, Inger Porsch Hällström
Sewage effluents contain pharmaceuticals, personal care products and industrial chemicals, exposing aquatic organisms to complex mixtures. The consequences of exposure to combinations of different classes of drugs in fish are largely unknown. In this study, we exposed adult zebrafish (Danio rerio) males and females for two weeks to low, environmentally relevant concentrations of the endocrine disrupting chemical 17α-etinylestradiol (EE2) and the selective serotonin re-uptake inhibitor (SSRI) citalopram, alone and in combination, and analyzed behaviors of importance for population fitness, scototaxis (light/dark preference), the novel tank test and shoal cohesion...
October 4, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28966088/retrotransposons-mimic-germ-plasm-determinants-to-promote-transgenerational-inheritance
#7
Bhavana Tiwari, Paula Kurtz, Amanda E Jones, Annika Wylie, James F Amatruda, Devi Prasad Boggupalli, Graydon B Gonsalvez, John M Abrams
Retrotransposons are a pervasive class of mobile elements present in the genomes of virtually all forms of life [1, 2]. In metazoans, these are preferentially active in the germline, which, in turn, mounts defenses that restrain their activity [3, 4]. Here we report that certain classes of retrotransposons ensure transgenerational inheritance by invading presumptive germ cells before they are formed. Using sensitized Drosophila and zebrafish models, we found that diverse classes of retrotransposons migrate to the germ plasm, a specialized region of the oocyte that prefigures germ cells and specifies the germline of descendants in the fertilized egg...
October 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28919937/gene-meter-accurate-abundance-calculations-of-gene-expression
#8
Alexander E Pozhitkov, Peter A Noble
We previously reported that thousands of transcripts in the mouse and zebrafish significantly increased in abundance in a time series spanning from life to several days after death. Transcript abundances were determined by: calibrating each microarray probe using a dilution series of pooled RNAs, fitting the probe-responses to adsorption models, and back-calculating abundances using the probe signal intensity of a sample and the best fitting model. The accuracy of the abundance measurements was not assessed in our previous study because individual transcript concentrations in the calibration pool were not known...
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/28838034/fate-and-effects-of-silver-nanoparticles-on-early-life-stage-development-of-zebrafish-danio-rerio-in-comparison-to-silver-nitrate
#9
Sébastien Cambier, Marthe Røgeberg, Anastasia Georgantzopoulou, Tommaso Serchi, Camilla Karlsson, Steven Verhaegen, Tore-Geir Iversen, Cédric Guignard, Marcin Kruszewski, Lucien Hoffmann, Jean-Nicolas Audinot, Erik Ropstad, Arno C Gutleb
The use of silver nanomaterials in everyday products, such as cosmetics, textiles, certain types of packaging, etc. is increasing, leading to their release into the environment, including aquatic ecosystems. This last point initiated this investigation on the toxicological effects of Ag nanoparticles (Ag NPs) in the aquatic model organism Danio rerio. For this purpose, zebrafish larvae were exposed to 20nm bare Ag NPs at different concentrations and AgNO3, used as a positive control for Ag(+) ions toxicity, at the beginning of their foraging behaviour to determine adverse effects on fitness parameters...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28814724/pathogenic-bacteria-enhance-dispersal-through-alteration-of-drosophila-social-communication
#10
Ian W Keesey, Sarah Koerte, Mohammed A Khallaf, Tom Retzke, Aurélien Guillou, Ewald Grosse-Wilde, Nicolas Buchon, Markus Knaden, Bill S Hansson
Pathogens and parasites can manipulate their hosts to optimize their own fitness. For instance, bacterial pathogens have been shown to affect their host plants' volatile and non-volatile metabolites, which results in increased attraction of insect vectors to the plant, and, hence, to increased pathogen dispersal. Behavioral manipulation by parasites has also been shown for mice, snails and zebrafish as well as for insects. Here we show that infection by pathogenic bacteria alters the social communication system of Drosophila melanogaster...
August 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28804037/the-longitudinal-effects-of-early-developmental-cadmium-exposure-on-conditioned-place-preference-and-cardiovascular-physiology-in-zebrafish
#11
Marissa Wold, Myranda Beckmann, Shelby Poitra, Ana Espinoza, Robert Longie, Erik Mersereau, Diane C Darland, Tristan Darland
Cadmium (Cd) is a naturally occurring trace metal that is widely considered to be highly toxic to aquatic organisms and a significant health hazard to humans (Amzal et al., 2009; Bernhoft 2013; Burger, 2008; Satarug et al., 2009). The zebrafish (Danio rerio) has been used as a model organism for toxicological studies with Cd (Banni et al., 2011; Blechinger et al., 2007; Chow et al., 2009; Chow et al., 2008; Favorito et al., 2011; Kusch et al., 2007; Matz et al., 2007; Wang and Gallagher, 2013). We asked what the lasting longitudinal effects would be from short early developmental Cd exposure (between 24 and 96h post-fertilization) in a range that larvae might experience living atop typical Cd-containing surface sediments (0, 0...
August 3, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28698378/haploid-selection-within-a-single-ejaculate-increases-offspring-fitness
#12
Ghazal Alavioon, Cosima Hotzy, Khriezhanuo Nakhro, Sandra Rudolf, Douglas G Scofield, Susanne Zajitschek, Alexei A Maklakov, Simone Immler
An inescapable consequence of sex in eukaryotes is the evolution of a biphasic life cycle with alternating diploid and haploid phases. The occurrence of selection during the haploid phase can have far-reaching consequences for fundamental evolutionary processes including the rate of adaptation, the extent of inbreeding depression, and the load of deleterious mutations, as well as for applied research into fertilization technology. Although haploid selection is well established in plants, current dogma assumes that in animals, intact fertile sperm within a single ejaculate are equivalent at siring viable offspring...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28696918/gold-nanorods-induce-early-embryonic-developmental-delay-and-lethality-in-zebrafish-danio-rerio
#13
Bárbara Mesquita, Isabel Lopes, Susana Silva, Maria João Bessa, Maksim Starykevich, Jorge Carneiro, Tiago L P Galvão, Mário G S Ferreira, João Tedim, João Paulo Teixeira, Sónia Fraga
Due to their unique electronic and optical features, gold nanoparticles (AuNP) have received a great deal of attention for application in different fields such as catalysis, electronics, and biomedicine. The large-volume manufacturing predicted for future decades and the inevitable release of these substances into the environment necessitated an assessment of potential adverse human and ecological risks due to exposure to AuNP. Accordingly, this study aimed to examine the acute and developmental toxicity attributed to a commercial suspension of Au nanorods stabilized with cetyltrimethylammonium bromide (CTAB-AuNR) using early embryonic stages of zebrafish (Danio rerio), a well-established model in ecotoxicology...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28673261/paternal-personality-and-social-status-influence-offspring-activity-in-zebrafish
#14
Susanne Zajitschek, James E Herbert-Read, Nasir M Abbasi, Felix Zajitschek, Simone Immler
BACKGROUND: Evidence for the transmission of non-genetic information from father to offspring is rapidly accumulating. While the impact of chemical and physical factors such as toxins or diet on the fitness of the parents and their offspring have been studied extensively, the importance of behavioural and social circumstances has only recently been recognised. Behavioural traits such as personality characteristics can be relatively stable, and partly comprise a genetic component but we know little about the non-genetic transmission of plastic behavioural traits from parents to offspring...
July 3, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28663543/nr3c1-null-mutant-zebrafish-are-viable-and-reveal-dna-binding-independent-activities-of-the-glucocorticoid-receptor
#15
N Facchinello, T Skobo, G Meneghetti, E Colletti, A Dinarello, N Tiso, R Costa, G Gioacchini, O Carnevali, F Argenton, L Colombo, L Dalla Valle
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish line with partially silenced gr (gr (s357/s357) ). Homozygous gr (-/-) larvae are morphologically inconspicuous and, in contrast to GR (-/-) knockout mice, viable through adulthood, although with reduced fitness and early life survival...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28657312/molecular-dynamics-flexible-fitting-simulations-identify-new-models-of-the-closed-state-of-the-cystic-fibrosis-transmembrane-conductance-regulator-protein
#16
Luba Simhaev, Nael A McCarty, Robert C Ford, Hanoch Senderowitz
Cystic fibrosis (CF) is a lethal, genetic disease found in particular in humans of European origin which is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. The search for CF therapies acting by modulating the impaired function of mutant CFTR will be greatly advanced by high resolution structures of CFTR in different states. To date, two medium resolution electron microscopy (EM) structures of CFTR are available (one of a distant zebrafish (Danio rerio) CFTR ortholog and one of human CFTR)...
August 28, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28620015/genetic-editing-of-the-androgen-receptor-contributes-to-impaired-male-courtship-behavior-in-zebrafish
#17
Lengxob Yong, Zayer Thet, Yong Zhu
Elucidating the genes that contribute to behavioral variation has become an important endeavor in behavioral studies. While advances in genomics have narrowed down the list of candidate genes, functional validation of them has lagged behind, partly because of challenges associated with rapid gene manipulations. Consequently, few studies have demonstrated causal genetic changes linked to behaviors. The 'gene editing revolution' has offered unprecedented opportunities to investigate candidate genes responsible for critical behaviors...
September 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28601762/warming-modulates-the-effects-of-the-endocrine-disruptor-progestin-levonorgestrel-on-the-zebrafish-fitness-ovary-maturation-kinetics-and-reproduction-success
#18
P G Cardoso, D Rodrigues, T V Madureira, N Oliveira, M J Rocha, E Rocha
Interactive effects between multiple stressors, namely climate drivers (e.g., temperature) and chemical pollution (e.g., endocrine disruptors) are poorly studied. Here, it was for the first time evaluated the combinatory effects of temperature and a synthetic progestin, levonorgestrel (LNG), on the fitness and reproductive-related endpoints of zebrafish (Danio rerio). A multi-factorial design was implemented by manipulating both temperature [setting as baseline an ambient temperature of 27 °C, against warming (+3 °C)] and LNG levels (10 ngL(-1) and 1000 ngL(-1))...
October 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28512313/a-rapid-capillary-pressure-driven-micro-channel-to-demonstrate-newtonian-fluid-behavior-of-zebrafish-blood-at-high-shear-rates
#19
Juhyun Lee, Tzu-Chieh Chou, Dongyang Kang, Hanul Kang, Junjie Chen, Kyung In Baek, Wei Wang, Yichen Ding, Dino Di Carlo, Yu-Chong Tai, Tzung K Hsiai
Blood viscosity provides the rheological basis to elucidate shear stress underlying developmental cardiac mechanics and physiology. Zebrafish is a high throughput model for developmental biology, forward-genetics, and drug discovery. The micro-scale posed an experimental challenge to measure blood viscosity. To address this challenge, a microfluidic viscometer driven by surface tension was developed to reduce the sample volume required (3μL) for rapid (<2 min) and continuous viscosity measurement. By fitting the power-law fluid model to the travel distance of blood through the micro-channel as a function of time and channel configuration, the experimentally acquired blood viscosity was compared with a vacuum-driven capillary viscometer at high shear rates (>500 s(-1)), at which the power law exponent (n) of zebrafish blood was nearly 1 behaving as a Newtonian fluid...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28346357/comparison-of-the-in-vivo-biotransformation-of-two-emerging-estrogenic-contaminants-bp2-and-bps-in-zebrafish-embryos-and-adults
#20
Vincent Le Fol, François Brion, Anne Hillenweck, Elisabeth Perdu, Sandrine Bruel, Selim Aït-Aïssa, Jean-Pierre Cravedi, Daniel Zalko
Zebrafish embryo assays are increasingly used in the toxicological assessment of endocrine disruptors. Among other advantages, these models are 3R-compliant and are fit for screening purposes. Biotransformation processes are well-recognized as a critical factor influencing toxic response, but major gaps of knowledge exist regarding the characterization of functional metabolic capacities expressed in zebrafish. Comparative metabolic studies between embryos and adults are even scarcer. Using ³H-labeled chemicals, we examined the fate of two estrogenic emerging contaminants, benzophenone-2 (BP2) and bisphenol S (BPS), in 4-day embryos and adult zebrafish...
March 25, 2017: International Journal of Molecular Sciences
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