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https://www.readbyqxmd.com/read/29458228/efficacy-of-epidural-analgesia-after-laparotomy-in-children
#1
Klarieke Bravenboer-Monster, Claudia Keyzer-Dekker, Monique van Dijk, Lonneke Staals, Tom de Leeuw, Rene Wijnen
BACKGROUND: Epidural analgesia (EDA) is used as postoperative pain treatment in children, but little is known about its efficacy after laparotomy in children. This retrospective study investigated the efficacy of postoperative EDA after laparotomy in children and the frequencies of adverse effects and complications. MATERIALS AND METHODS: Data of all children aged 0 to 18 years undergoing laparotomy and treated with EDA in our hospital from January 2014 to December 2015 were collected...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29458225/-indication-quality-concepts-and-ethical-implications
#2
Andrea Dörries
BACKGROUND: In recent times - also due to new laws - a good "indication quality" has been called for. The aim of this paper is to contribute to the debate about "indication quality" by looking into the meaning of the term "indication" as well as the meaning of an adequate understanding of quality. METHODS: Initially, a conceptual analysis is made of how indication is an integral part of the therapeutic decision-making process between physician and patient, in which, next to evidence-based elements, also normative elements are included (step 1)...
February 19, 2018: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29458217/a-new-two-dimensional-shear-wave-elastography-for-noninvasive-assessment-of-liver-fibrosis-in-healthy-subjects-and-in-patients-with-chronic-liver-disease
#3
Carla Serra, Valentina Grasso, Fabio Conti, Cristina Felicani, Elena Mazzotta, Marco Lenzi, Gabriella Verucchi, Antonietta D'errico, Pietro Andreone
PURPOSE: To assess the performance of two-dimensional shear wave elastography (2D-SWE) on the GE LOGIQ E9 ultrasound system in a cohort of healthy subjects and to investigate its accuracy in the staging of liver fibrosis in patients with chronic liver disease (CLD) using liver biopsy as a reference standard. MATERIALS AND METHODS: From October 2014 to June 2016, 54 healthy subjects and 174 patients with CLD were consecutively enrolled. Liver fibrosis stage was assessed by the METAVIR scoring system...
February 19, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29458213/selective-targeting-and-degradation-of-doxorubicin-loaded-folate-functionalized-dna-nanocages
#4
Sofia Raniolo, Giulia Vindigni, Alessio Ottaviani, Valeria Unida, Federico Iacovelli, Antonio Manetto, Mariangela Figini, Lorenzo Stella, Alessandro Desideri, Silvia Biocca
Selective targeting is a crucial property of nanocarriers used for drug delivery in cancer therapy. We generated biotinylated octahedral DNA nanocages functionalized with folic acid through bio-orthogonal conjugation chemistry. Molecular modelling indicated that a distance of about 2.5 nm between folic acid and DNA nanocage avoids steric hindrance with the folate receptor. HeLa cells, a folate receptor positive tumour cell line, internalize folate-DNA nanocages with efficiency greater than 40 times compared to cells not expressing the folate receptors...
February 16, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29458209/dermal-anti-oxidant-anti-inflammatory-and-anti-aging-effects-of-compritol-ato-based-resveratrol-colloidal-carriers-prepared-using-mixed-surfactants
#5
Haidy Abbas, Rabab Kamel, Nesrine El-Sayed
In this study, Compritol ATO-based Resveratrol colloidal carriers (CCCs) were prepared. In most formulae, the use of a binary-mixture of surfactants improved the physicochemical properties. CCC6 (containing P407/P188 as bi-surfactants) attained the highest drug loading, release efficiency during 24 hr and occlusive effect for 48 hr; in addition to, a uniform particle size distribution within the desired range. In-vivo studies were done based on the analysis of anti-oxidant markers [catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD)], anti-inflammatory markers [interleukin 6 (IL-6), interleukin 8 (IL-8) and rat Nuclear factor-kappa B (NF-κB)] and anti-wrinkling markers [matrix metalloproteinase (MMP-1) and Granulocyte-macrophage colony-stimulating factor (GM-CSF)], after UVB-irradiation...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458176/grp78-promotes-hepatocellular-carcinoma-proliferation-by-increasing-fat10-expression-through-the-nf-%C3%AE%C2%BAb-pathway
#6
Chenglin Luo, Haixia Xiong, Leifeng Chen, Xiuxia Liu, Shubing Zou, Jiafu Guan, Kai Wang
Glucose-regulated protein 78(GRP78) and the ubiquitin-like protein FAT10 each promote proliferation in hepatocellular carcinoma(HCC). However, the relationship of GRP78 and FAT10 in HCC proliferation are still not known. In this study, we found that GRP78 and FAT10 were significantly overexpressed in HCC tissues compare with adjacent non-cancerous tissues, and a positive correlation was found between their expression and associated proliferation characteristics. High expression of GRP78 and FAT10 were positively correlated with tumor proliferation and poor prognosis in HCC...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458175/maintenance-of-hematopoietic-stem-and-progenitor-cells-in-fetal-intra-aortic-hematopoietic-clusters-by-the-sox17-notch1-hes1-axis
#7
Kiyoka Saito, Ikuo Nobuhisa, Kaho Harada, Satomi Takahashi, Maha Anani, Heiko Lickert, Masami Kanai-Azuma, Yoshiakira Kanai, Tetsuya Taga
The aorta-gonad-mesonephros region, from which definitive hematopoiesis first arises in midgestation mouse embryos, has intra-aortic hematopoietic clusters (IAHCs) containing hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). We previously reported expression of the transcription factor Sox17 in IAHCs, and overexpression of Sox17 in CD45low c-KIThigh cells comprising IAHCs maintains the formation of cell clusters and their multipotency in vitro over multiple passages. Here, we demonstrate the importance of NOTCH1 in IAHC formation and maintenance of the HSC/HPC phenotype...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458174/networks-that-link-cytoskeletal-regulators-and-diaphragm-proteins-underpin-filtration-function-in-drosophila-nephrocytes
#8
Simi Muraleedharan, Aksah Sam, Helen Skaer, Maneesha S Inamdar
Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They possess an exceptional macromolecular assembly, the nephrocyte diaphragm (ND), which serves as a filtration barrier and helps maintain tissue homeostasis by filtering out wastes and toxic products. However, the elements that maintain nephrocyte architecture and the ND are not understood. We show that Drosophila nephrocytes have a unique cytoplasmic cluster of F-actin, which is maintained by the microtubule cytoskeleton and Rho-GTPases...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458172/modelling-human-myoblasts-survival-upon-xenotransplantation-into-immunodeficient-mouse-muscle
#9
Christophe Praud, Karine Vauchez, Pascal Zongo, Jean-Thomas Vilquin
Cell transplantation has been challenged in several clinical indications of genetic or acquired muscular diseases, but therapeutic success were mitigated. To understand and improve the yields of tissue regeneration, we aimed at modelling the fate of CD56-positive human myoblasts after transplantation. Using immunodeficient severe combined immunodeficiency (SCID) mice as recipients, we assessed the survival, integration and satellite cell niche occupancy of human myoblasts by a triple immunohistochemical labelling of laminin, dystrophin and human lamin A/C...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458147/sessein-and-isosessein-with-anti-inflammatory-antibacterial-and-antioxidant-activity-isolated-from-salvia-sessei-benth
#10
Abraham Gómez-Rivera, Manasés González-Cortazar, Maribel Herrera-Ruíz, Alejandro Zamilpa, Verónica Rodríguez-López
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia sessei Benth, popularly known as "pipilolxochitl" or "sabanito", is a plant utilized in Mexico in traditional medicine for the treatment of erysipela. To date, only one report, to our knowledge, has been found in which a royleanone-type diterpene of the aerial parts of the species was isolated but, again to our knowledge, studies have not been conducted on the pharmacological activity of extracts and compounds isolated from this plant...
February 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29458145/the-c-ebp%C3%AE-linc01133-axis-promotes-cell-proliferation-in-pancreatic-ductal-adenocarcinoma-through-upregulation-of-ccng1
#11
Chen-Song Huang, Junjun Chu, Xiao-Xu Zhu, Jian-Hui Li, Xi-Tai Huang, Jian-Peng Cai, Wei Zhao, Xiao-Yu Yin
Long non-coding RNAs (lncRNAs) are emerging as important regulators and prognostic markers of multiple cancers. Our aim was to determine functional involvement of lncRNAs in pancreatic ductal adenocarcinoma (PDAC). In this study, we report that LINC01133 expression is higher in PDAC tissues compared to adjacent non-cancerous tissues, and this overexpression is associated with poorer prognosis among the patients. In vitro, a knockdown of LINC01133 substantially decreased PDAC cell proliferation. Tumorigenicity of PDAC cells with the LINC01133 knockdown was significantly impaired in a xenograft model assay...
February 16, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29458136/changes-in-anatomic-position-of-root-canal-orifices-in-pluriradicular-teeth-following-re-location-during-endodontic-treatment
#12
Darian Rusu, Petra Surlin, Stratul Stefan-Ioan, Marius Boariu, Calniceanu Horia, Adrian Kasaj, Cosmin Sinescu, Didilescu Andreea
Direct access to the root canals in posterior teeth for endodontic treatment is most frequently facilitated by the straightening of the coronal parts of the root canals, having as a consequence the relocation of the canal orifices on the map of the floor of the pulp chamber (Christie & Thompson, 1994). This procedure intentionally moves the coronal aspect of a canal away from the center of the chamber, while simultaneously removing internal dentin from the pulp chamber walls. The aim of this study was to evaluate the displacement resulting from the relocation of root canal orifices during the initial phase of rotary root canal treatment in molars using the dental operating microscope (DOM) and digital image processing...
February 16, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29458128/aggregation-prone-regions-in-hypk-help-it-to-form-sequestration-complex-for-toxic-protein-aggregates
#13
Debasish Kumar Ghosh, Ajit Roy, Akash Ranjan
Protein aggregates result from altered structural conformations and they can perturb cellular homeostasis. Prevention mechanisms, which function against protein aggregation by modulatory processes, are diverse and redundant. In this study, we have characterized Huntingtin interacting protein K (HYPK) as a global aggregation-regulatory protein. We report the mechanistic details of how HYPK's aggregation-prone regions allow it to sense and prevent other toxic protein's aggregation by forming unique annular-shaped sequestration complexes...
February 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29458116/junk-food-advertising-moderates-the-indirect-effect-of-reward-sensitivity-and-food-consumption-via-the-urge-to-eat
#14
Chloe Kidd, Natalie J Loxton
The current study aimed to identify how underlying individual differences increases vulnerability to television food advertising. In particular, this study examined how reward sensitivity, a biologically-based predisposition to approach rewards (such as appetitive foods) in the environment, influenced participants' vulnerability to television food advertising and subsequent food consumption. Ninety-eight participants were randomly assigned to a cue condition (food cues versus non-food cues) and then viewed a 30 min documentary interrupted by advertising featuring a mix of food and neutral advertising (food cue condition) or only neutral advertising (non-food cue condition)...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458113/poorer-positive-affect-in-response-to-self-paced-exercise-among-the-obese
#15
Hassan M Elsangedy, Paulo H D Nascimento, Daniel G S Machado, Kleverton Krinski, Sarah J Hardcastle, Sérgio G DaSilva
We aimed to investigate the association between body mass index (BMI) and affective response, ratings of perceived exertion (RPE), and physiological responses during self-paced exercise. Sixty-six women were divided into three groups accordingly with the BMI: obese (n = 22: 33.5 ± 8.5 yr; 34.9 ± 4.1 kg∙m-2 ), overweight (n = 22: 34.8 ± 8.6 yr; 26.4 ± 1.3 kg∙m-2 ), and normal-weight (n = 22: 30.8 ± 9.3 yr; 22.0 ± 1.6 kg∙m-2 ). They underwent a graded exercise test and a 20-min self-paced walking session on a treadmill...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458112/compatible-osmolytes-modulate-mitochondrial-function-in-a-marine-osmoconformer-crassostrea-gigas-thunberg-1793
#16
Eugene P Sokolov, Inna M Sokolova
Salinity is an important environmental factor affecting physiology of marine organisms. Osmoconformers such as marine mollusks maintain metabolic function despite changes of the osmolarity and composition of the cytosol during salinity shifts. Currently, metabolic responses to the salinity-induced changes of the intracellular milieu are not well understood. We studied the effects of osmolarity (450 vs. 900 mOsm) and compatible osmolytes (70-590 mM of taurine or betaine) on isolated gill mitochondria of a marine osmoconformer, the Pacific oyster Crassostrea gigas...
February 16, 2018: Mitochondrion
https://www.readbyqxmd.com/read/29458109/modulation-of-cyp1a1-metabolism-from-adverse-health-effects-to-chemoprevention-and-therapeutic-options
#17
Melina Mescher, Thomas Haarmann-Stemmann
The human cytochrome P450 (CYP) 1A1 gene encodes a monooxygenase that metabolizes multiple exogenous and endogenous substrates. CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens. CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins...
February 16, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29458103/zinc-oxide-nanorod-clusters-deposited-seaweed-cellulose-sheet-for-antimicrobial-activity
#18
Priyank L Bhutiya, Mayur S Mahajan, M Abdul Rasheed, Manoj Pandey, S Zaheer Hasan, Nirendra Misra
Seaweed cellulose was isolated from green seaweed Ulva fasciata using a common bleaching agent. Sheet containing porous mesh was prepared from the extracted seaweed crystalline cellulose along with zinc oxide (ZnO) nanorod clusters grown over the sheet by single step hydrothermal method. Seaweed cellulose and zinc oxide nanorod clusters deposited seaweed cellulose sheet was characterized by FT-IR, XRD, TGA, and SEM-EDX. Morphology showed that the diameter of zinc oxide nanorods were around 70 nm. Zinc oxide nanorod clusters deposited on seaweed cellulose sheet gave remarkable antibacterial activity towards gram-positive (Staphylococcus aureus, Bacillus ceresus, Streptococcus thermophilis) and gram-negative (Escherichia coli, Pseudomonas aeruginous) microbes...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458093/protective-efficacy-of-mucuna-pruriens-l-seed-meal-enriched-diet-on-growth-performance-innate-immunity-and-disease-resistance-in-oreochromis-mossambicus-against-aeromonas-hydrophila
#19
Mohamed Saiyad Musthafa, Syed Mohideen Asgari, Amitha Kurian, Elumalai Preetham, Abdul Rahman Jawahar Ali, Bilal Ahmad Paray, Mohammad K Al-Sadoon
The impact of Mucuna pruriens (L.) seed meal diet on growth performance, innate immune response, and disease resistance in Oreochromis mossambicus against Aeromonas hydrophila is reported for the first time. Infected O. mossambicus was fed with 2 g kg-1 , 4 g kg-1 , and 6 g kg-1 of M. pruriens seed meal diets significantly increased initial body weight (IBW) and final body weight (FBW) over control, for a period of 4 weeks. At 4 g kg-1 and 6 g kg-1 the enriched diet significantly (P < 0.05) enhanced the survival rate, weight gain (WG), protein efficiency ratio (PER), specific growth rate (SGR), feed conversion ratio (FCR), and feed efficiency (FE) when compared to the control; besides, from weeks 2-4 these diets significantly (P < 0...
February 16, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29458087/ngf-fak-signal-pathway-is-implicated-in-angiogenesis-after-acute-cerebral-ischemia-in-rats
#20
Hai-Ting Zhao, Yu-Hu Zhang, Ying-Hui Zhang, Yue Shen, Yi-Dan Zhang, Fang-Fang Bi, Bo Xiao, Hao Zhang, Wen Ye, Hong-Hai Zhang, Yi-Wei Liao
Neurogenesis in the cerebral infarction after an ischemic event is important to the rehabilitation of patients. However, the mechanism of angiogenesis around cerebral ischemia is not clear. Our study designed to test whether the nerve growth factor (NGF)-P-focal adhesion kinase (FAK) signaling pathway for associations with angiogenesis plays a key role in post-acute cerebral ischemia of rats. Firstly, we implanted the Matrigel, a carrier of basement membrane matrix, into the abdominal skin of rats to identify the relevant components of the NGF-P-FAK signaling pathway related to angiogenesis...
February 16, 2018: Neuroscience Letters
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