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https://www.readbyqxmd.com/read/28644191/yield-of-cytology-surveillance-after-high-grade-vulvar-intraepithelial-neoplasia-or-cancer
#1
Lindsay M Kuroki, Antonina I Frolova, Ningying Wu, Jingxia Liu, Matthew Powell, Premal H Thaker, L Stewart Massad
OBJECTIVES: The aim of the study was to estimate the risk of high-grade cervical and vaginal intraepithelial neoplasia (CIN/VAIN 2+) and cancer among women treated surgically for high-grade vulvar intraepithelial neoplasia (HGVIN) and vulvar cancer. MATERIALS AND METHODS: We performed a retrospective cohort study of women who underwent surgery for HGVIN/vulvar cancer between 2006 and 2010. Univariate and multivariate analyses using stepwise selection were used to identify correlates of abnormal cytology after treatment for VIN and vulvar cancer...
July 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28639874/compression-treatment-of-pelvic-congestion-syndrome
#2
S G Gavrilov, A V Karalkin, O O Turischeva
Aim To study the influence of compression treatment on clinical manifestations and venous hemodynamics of the pelvis in patients with pelvic congestion syndrome. Materials and methods A prospective study of the various options and modes of compression treatment was carried out and included 74 patients with pelvic congestion syndrome in 2008-2015. The patients were divided into three groups. The first group consisted of 48 patients with symptoms of pelvic congestion syndrome and chronic pelvic pain. They used Class II compression shorts...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28638271/proex-c-as-diagnostic-marker-for-detection-of-urothelial-carcinoma-in-urinary-samples-a-review
#3
REVIEW
Gerardo Botti, Maria Gabriella Malzone, Elvira La Mantia, Micaela Montanari, Daniela Vanacore, Sabrina Rossetti, Vincenzo Quagliariello, Carla Cavaliere, Rossella Di Franco, Luigi Castaldo, Gianluca Ametrano, Francesca Cappuccio, Francesco Jacopo Romano, Raffaele Piscitelli, Maria Filomena Pepe, Carmine D'Aniello, Gaetano Facchini
The gold standard for the detection of urothelial carcinoma is represented by urethro-cystoscopy and biopsy. Both procedures are invasive and expensive and therefore cytology is often used as first approach to investigate on a possible neoplasia, being a safe and cost-effective diagnostic modality of evaluation. Because cytology alone is not highly sensitive for detection of low grade urothelial carcinoma and recurrence of the disease, several adjunct markers and urine based tests for urothelial carcinoma have been developed, which can help in the final diagnosis...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28637507/dysregulated-expression-of-long-noncoding-rnas-in-gynecologic-cancers
#4
REVIEW
Elahe Seyed Hosseini, Matthieu Meryet-Figuiere, Hamed Sabzalipoor, Hamed Haddad Kashani, Hossein Nikzad, Zatollah Asemi
Cancers of the female reproductive system include ovarian, uterine, vaginal, cervical and vulvar cancers, which are termed gynecologic cancer. The emergence of long noncoding RNAs (lncRNAs), which are believed to play a crucial role in several different biological processes, has made the regulation of gene expression more complex. Although the function of lncRNAs is still rather elusive, their broad involvement in the initiation and progression of various cancers is clear. They are also involved in the pathogenesis of cancers of the female reproductive system...
June 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28625396/management-of-menopausal-symptoms-in-women-with-gynecologic-cancers
#5
REVIEW
Marcela G Del Carmen, Laurel W Rice
OBJECTIVE: Women with gynecologic malignancies will be cured or may become long-term survivors. Management of menopausal symptoms is important in addressing their quality of life. We review the benefit and safety of hormone therapy use in these patients. METHODS: MEDLINE was searched for studies on menopause management published in English through December of 2016. RESULTS: Available data suggest that short-term use of hormone therapy in gynecologic cancer patients who do not have an estrogen-dependent malignancy do not adversely impact oncologic outcome and results in improvement of menopausal vasomotor and genitourinary symptoms...
June 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28624874/reliable-molecular-differentiation-of-trichuris-ovis-and-trichuris-discolor-from-sheep-ovis-orientalis-aries-and-roe-deer-capreolus-capreolus-and-morphological-characterisation-of-their-females-morphology-does-not-work-sufficiently
#6
Pavel Vejl, Stanislava Nechybová, Pavla Peřinková, Martina Melounová, Vladimíra Sedláková, Jakub Vašek, Daniela Čílová, Kateřina Rylková, Ivana Jankovská, Jaroslav Vadlejch, Iva Langrová
The main aim of the study was to evaluate associations between morphological variability of Trichuris females from sheep and roe deer and their rDNA polymorphism in whipworm populations from the Czech Republic. The results introduced the use of new molecular markers based on the internal transcribed spacer (ITS)1-5.8S RNA-ITS2 region polymorphisms, as useful tools for the unambiguous differentiation of congeners Trichuris ovis and Trichuris discolor. These markers revealed both parasites in roe deer and in sheep; however, T...
June 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28624154/lymphedema-following-gynecological-cancer-results-from-a-prospective-longitudinal-cohort-study-on-prevalence-incidence-and-risk-factors
#7
Sandra C Hayes, Monika Janda, Leigh C Ward, Hildegard Reul-Hirche, Megan L Steele, Johnathan Carter, Michael Quinn, Bruce Cornish, Andreas Obermair
OBJECTIVE: Cancer-related lymphedema is a debilitating condition that adversely influences function, health and quality of life. The purpose of this study was to assess the prevalence, incidence, and risk factors of lower-limb lymphedema pre- through to 24months post-surgery for gynecological cancer. METHODS: A clinic-based sample of women (n=408) with gynecological cancer participated in a prospective, longitudinal study (2008-2011) using self-reported measures (swelling in one or both legs) and objectively measured lymphedema (bioimpedance spectroscopy) at baseline (pre-surgery), six weeks-three months, 6-12months, and 15-24months post-surgery...
June 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28608762/limiting-the-morbidity-of-inguinofemoral-lymphadenectomy-in-vulvar-cancer-patients-a-review
#8
Anne-Floor W Pouwer, Henriette J Arts, Jacobus van der Velden, Joanne A de Hullu
Inguinofemoral lymphadenectomy (IFL) is performed in the treatment for vulvar cancer. One or more complications after IFL is reported in up to 85% of the patients. This review presents an overview of surgical techniques and peri- and post-operative care that has been studied in order to reduce the morbidity associated with IFL in vulvar cancer patients. Areas covered: Current knowledge on post-operative complications after different surgical techniques and peri- and post-operative protocols were discussed. A systematic literature review was conducted using MEDLINE, EMBASE and the Cochrane library on 20 February 2017...
June 13, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28602173/clinical-significance-and-prognostic-value-of-femoral-lymph-node-metastasis-in-figo-stage-iii-vulvar-carcinoma
#9
H Tu, P Sun, H F Gu, X K Zhang, H Huang, T Wan, J H Liu
OBJECTIVES: To determine the clinical significance and prognostic value of femoral lymph node metastasis (FLNM) in patients with International Federation of Gynecology and Obstetrics (FIGO) stage III vulvar carcinoma. METHODS: The medical records of patients with vulvar carcinoma who underwent inguinofemoral lymphadenectomy between 1990 and 2013 were retrospectively reviewed. RESULTS: Of 66 patients with stage III vulvar carcinoma, 42 had superficial lymph node metastasis (SLNM) only and 24 had FLNM...
May 31, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28600034/the-video-endoscopy-inguinal-lymphadenectomy-for-vulvar-cancer-a-pilot-study
#10
Angelica Naldini, Cristiano Rossitto, Fabio Pacelli, Giuseppe Vizzielli, Giuseppe Campagna, Maria Cristina Moruzzi, Giovanni Scambia
OBJECTIVE: This prospective pilot study aims to validate feasibility, efficacy and safeness of the innovative technique of video endoscopy inguinal lymphadenectomy (VEIL) and compare it to open inguinal lymphadenectomy (OIL) in the staging and treatment of vulvar cancer (VC). MATERIAL AND METHODS: All patients affected by VC suitable for bilateral inguinal-femoral lymphadenectomy were prospectively enrolled and submitted to VEIL on one side and OIL contralaterally, sparing the saphenous vein...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28598450/lower-genital-tract-trauma-in-a-tertiary-care-centre-in-mid-western-nepal
#11
A K Adhikari, M Dutta, C R Das
INTRODUCTION: The study of lower genital tract trauma has become important in gynaecological practice. There is paucity of reports on this clinical entity from our settings. The main aim of this study is to document injuries in female lower genital tract in Mid-Western Nepal. METHODS: Sixty female patients admitted to the hospital with genital tract injuries caused by coitus or accidents were included in the study. Details of the causes of trauma clinical presentations and management were recorded...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28593367/vulvar-lichen-sclerosus-in-women-is-associated-with-lower-urinary-tract-symptoms
#12
Corina Christmann-Schmid, Melanie Hediger, Sabine Gröger, Jörg Krebs, Andreas R Günthert
INTRODUCTION AND HYPOTHESIS: Lichen sclerosus (LS) is thought to be primarily a disease of postmenopausal women. Little is reported about lower urinary tract symptoms (LUTS) in association with LS. The aims of this study were to evaluate the odds of having LS-associated LUTS and to identify the predominant type of LS-associated bladder dysfunction. METHODS: This was a cross-sectional study with two cohorts investigating the association between LS and LUTS and the predominant type of LS-associated bladder dysfunction...
June 7, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28590952/role-of-human-papillomavirus-in-vulvar-cancer
#13
Natalia Rakislova, Adela Saco, Adriana Sierra, Marta Del Pino, Jaume Ordi
Human papillomavirus (HPV) is involved in one of the at least 2 pathways leading to vulvar squamous cell carcinoma (VSCC). Inactivation of p53 and retinoblastoma by the viral products E6 and E7 is involved in malignant transformation. The percentage of HPV-positive VSCCs ranges from 18% to 75%, depending on the geographical area. HPV-associated tumors affect relatively young women and arise from high-grade intraepithelial lesions, identical to other HPV-associated premalignant lesions of the anogenital tract...
July 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28577297/prevalence-and-type-distribution-of-human-papillomavirus-in-squamous-cell-carcinoma-and-intraepithelial-neoplasia-of-the-vulva
#14
Mette T Faber, Freja L Sand, Vanna Albieri, Bodil Norrild, Susanne K Kjaer, Freija Verdoodt
In this updated systematic review and meta-analysis, we estimate the pooled prevalence of human papillomavirus (HPV) DNA and HPV type distribution in squamous cell carcinoma of the vulva (vulvar cancer) and vulvar intraepithelial neoplasia (VIN). PubMed, Embase and Cochrane Library databases were used to identify studies published between 1990 and 2015 and using a PCR-based or hybrid capture test to evaluate the presence of HPV DNA in vulvar cancer or VIN. Pooled estimates of the HPV prevalence with corresponding 95% confidence intervals (CI) were calculated based on a random effects model...
June 2, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28574130/hpv-related-vulvar-diseases-and-perspectives-of-p16ink4a-immunochemistry-a-review-of-the-literature
#15
Angela Carrone, Lucia Riganelli, Delia Savone, Assunta Casorelli, Lucia Merlino, Francesco Pecorini, Irene Pecorella, Pasquale Mancino, Maria Grazia Piccioni, Pierluigi Benedetti Panici
INTRODUCTION: Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap...
May 26, 2017: Tumori
https://www.readbyqxmd.com/read/28570452/comparison-of-v-y-advancement-flap-versus-lotus-petal-flap-for-plastic-reconstruction-after-surgery-in-case-of-vulvar-malignancies-a-retrospective-single-center-experience
#16
Pier Luigi Confalonieri, Roberta Gilardi, Luca Carlo Rovati, Anna Ceccherelli, Ji Hye Lee, Sonia Magni, Massimo Del Bene, Alessandro Buda
Vulvoperineal defects after demolitive surgery for preneoplastic or malignant vulvar lesions require a reconstruction to restore good sexual functions and to offer a satisfactory cosmetic result. Several techniques of reconstruction have been described in the past, leading to a more conservative and localized treatment. This study retrospectively reviewed patients with primary or recurrent vulvar malignancies that had undergone vulvoperineal reconstruction between 2010 and 2016 using the V-Y advancement flap and the 2 variant of the lotus petal flap (LPF) in terms of surgical outcome and postoperative complications...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28570256/the-vulva-an-uncommon-presentation-of-a-pressure-ulcer
#17
Elena Conde Montero, José María Martínez Gómiz, Pablo de la Cueva Dobao
Pressure ulcers may develop in different locations. Vulvar pressure ulcers can be easily misdiagnosed and, moreover, have been rarely reported in the literature. Surgical procedures that involve prolonged pressure on this area may trigger these lesions. CASE REPORT: The authors present a case of a vulvar pressure ulcer secondary to the use of a perineal post to provide countertraction during surgical repair of a hip fracture. Diagnosis was made after excluding other possible causes with anatomopathological and microbiological analysis...
May 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28565920/vulvar-basal-cell-carcinoma-four-case-reports-with-immunohistochemical-study
#18
Mª Reyes García-de-la-Fuente, Maria Santacana, Felip Vilardell, R M Pujol, Eloi Gari, J M Casanova
Basal cell carcinomas (BCC) are the most frequent tumours in humans and normally appear in photoexposed areas of the skin. It is widely accepted that BCCs originate at follicular stem cells and consequently are very rare in nonhairy areas. Here, we report 4 cases of vulvar BCC, 3 of which were located in a vulvar semimucous area, a nonphotoexposed area, and a nonhairy area. We have determined the CK7 and CK19 profile of all cases; both are markers of simple epithelium with glandular differentiation. Interestingly, all cases were positively stained for CK7 and CK19...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28556593/comparative-molecular-profiling-of-hpv-induced-squamous-cell-carcinomas
#19
Robert F Koncar, Rebecca Feldman, El Mustapha Bahassi, Nooshin Hashemi Sadraei
Approximately 5% of all cancer incidences result from human papillomavirus (HPV) infection. HPV infection most commonly leads to cancers of the anogenital region or oropharynx. It is unknown whether different HPV-mediated cancers collectively share a molecular signature and it is important to determine if there are targetable alterations common to different types of HPV-positive tumors. We analyzed 743 p53 wild-type samples of anal, cervical, oropharyngeal, and vulvar squamous cell carcinomas which underwent multiplatform testing at a commercial molecular profiling service...
May 29, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28551932/-hormone-replacement-therapy-after-gynecological-malignancies
#20
REVIEW
Nadav Michaan, Dan Grisaru
Treatment of gynecological malignancies can cause an abrupt onset of menopausal symptoms along with associated long term morbidity. Hormone replacement therapy (HRT) is the most effective treatment to alleviate these symptoms but the safety of HRT among gynecologic oncology patients remains controversial. We conducted a review of the published literature on the risk of recurrent disease among gynecologic cancer patients using HRT. Our research revealed a shortage of prospective, randomized trials on this important subject...
March 2017: Harefuah
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