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https://www.readbyqxmd.com/read/29785390/platelet-rich-plasma-prp-for-the-treatment-of-vulvar-lichen-sclerosus-in-a-premenopausal-woman-a-case-report
#1
D Franic, Z Iternička, M Franić-Ivanišević
The use of platelet-rich plasma (PRP) for the treatment of lichen sclerosus (LS) in a 38-year-old premenopausal woman is reported. The diagnosis was confirmed histologically and the symptoms documented using the ICIQ Vaginal Symptoms Questionnaire (ICIQ-VS) and the Female Sexual Function Index (FSFI) questionnaire. PRP was prepared from autologous blood using the Regen Cellular Matrix Kit. PRP was administered twice over two months. Histology at follow-up one month after the second administration showed the epidermis was nearly normal and upper dermal cellularity had been restored...
April 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29785335/raised-vulvar-lesions-be-aware
#2
Fernanda S Resende, Claudio Conforti, Roberta Giuffrida, Mayara Hamilko de Barros, Iris Zalaudek
Vulvar melanoma is a rare and deadly cancer in women, and the prognosis is often poor. There are limited studies on the dermoscopic features of vulvar melanoma. Described criteria include the presence of blue, gray, or white colors. Herein we present the clinical and dermoscopic characteristics of a hypopigmented and heavily pigmented nodule in a 92-year-old and an 80-year-old woman. Dermoscopy in the former revealed structureless milky-red to white areas, remnants of brown pigmentation at the base and polymorphic vessels, while the latter displayed structureless blue-gray areas with black dots and peripheral lines at the base...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29778480/relationship-between-herd-size-and-measures-of-animal-welfare-on-dairy-cattle-farms-with-freestall-housing-in-germany
#3
Daniel Gieseke, Christian Lambertz, Matthias Gauly
The objective of this study was to examine the association of herd size with animal welfare in dairy cattle herds. Therefore, 80 conventional dairy cattle farms were classified by the number of cows into 4 herd size classes, C1 (<100 cows), C2 (100-299 cows), C3 (300-499 cows), and C4 (≥500 cows), and assessed using multiple animal-based measures of the Welfare Quality Assessment protocol for dairy cattle. Data were recorded from April 2014 to September 2016 by an experienced single assessor in Northern Germany...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29767492/solitary-vulvar-neurofibroma-in-a-patient-without-neurofibromatosis
#4
Filomena Russo, Virginia Mancini, Paolo Taddeucci, Michele Fimiani
No abstract text is available yet for this article.
August 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29761782/-vulvar-intraepithelial-neoplasia
#5
Signe Østergård, Christina Steen Vorbeck, Mette Meinert
Vulvar intraepithelial neoplasia (VIN) is a rare but premalig-nant condition. VIN has two aetiological pathways: a human papillomavirus (HPV)-dependent pathway, which is a vulvar high-grade squamous intraepithelial lesion (HSIL), and an HPV-independent pathway, called differentiated VIN (d-VIN), associated with lichen sclerosus. d-VIN is more aggressive than vulvar HSIL. In case of symptoms, a biopsy should be performed. The recurrence risk is high: 25-50% regardless of treatment type. We recommend treatment with imiquimod as first choice to avoid mutilating surgery...
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29752211/treatment-of-vulvar-mycosis-fungoides-tumors-with-localized-radiotherapy
#6
Shamir Geller, Ken Pitter, Alison Moskowitz, Steven M Horwitz, Joachim Yahalom, Patricia L Myskowski
No abstract text is available yet for this article.
May 4, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29750709/classic-vulvar-intraepithelial-neoplasia-with-superimposed-lichen-simplex-chronicus-a-unique-variant-mimicking-differentiated-vulvar-intraepithelial-neoplasia
#7
Jaclyn C Watkins, Eric Yang, Christopher P Crum, Michael Herfs, Tarik Gheit, Massimo Tommasino, Marisa R Nucci
High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC)...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29745285/p16-expression-in-extramammary-paget-s-disease-of-the-vulva-and-scrotum-is-not-human-papillomavirus-related
#8
Khaleel I Al-Obaidy, Chia-Sui Kao, Muhammad T Idrees
INTRODUCTION: Extramammary Paget disease (EMPD) of the vulva has been shown to express p16 by immunohistochemistry (IHC), however, p16 expression in the vulva and scrotum has not been extensively studied in relation to human papillomavirus (HPV) within EMPD of both the vulva and scrotum. DESIGN: Twenty-two cases of EMPD (vulva, 16; scrotum, 6) were found in our laboratory information system. P16 and HPV IHC were performed. Any p16 reactivity less than 10% was considered negative...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29745269/biophysical-and-photobiological-basics-of-water-filtered-infrared-a-hyperthermia-of-superficial-tumors
#9
Peter Vaupel, Helmut Piazena, Werner Müller, Markus Notter
Thermography-controlled, water-filtered infrared-A (wIRA) is a novel, effective and approved heating technique listed in the ESHO quality assurance guidelines for superficial hyperthermia clinical trials (2017). In order to assess the special features and the potential of wIRA-hyperthermia (wIRA-HT), detailed and updated information about its physical and photobiological background is presented. wIRA allows for (a) application of high irradiances without skin pain and acute grade 2-4 skin toxicities, (b) prolonged, therapeutically relevant exposure times using high irradiances (150-200 mW/cm2 ) and (c) faster and deeper heat extension within tissues...
May 10, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29743937/epidemiologic-and-economic-burden-of-hpv-diseases-in-spain-implication-of-additional-5-types-from-the-9-valent-vaccine
#10
Noelia López, Aureli Torné, Agustín Franco, María San-Martin, Elisabet Viayna, Carmen Barrull, Nuria Perulero
Background: A new nonavalent human papillomavirus (HPV) vaccine that includes genotypes 6/11/16/18/31/33/45/52/58 has been recently approved in Spain. A previous study has shown that attributable fraction of HPV related diseases in Spain is consistent with that reported in European and global studies. The aim of the present study was to estimate the annual direct costs associated to the following HPV-related diseases: genital warts, high grade precancerous lesions and cancer of cervix, vulva, vagina, anus and penis and head and neck cancer, caused by genotypes included in the nonavalent (9vHPV) and quadrivalent vaccines (4vHPV), in Spanish men and women...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29742925/widowed-status-increases-the-risk-of-death-in-vulvar-cancer
#11
San-Gang Wu, Qing-Jiang Lin, Feng-Yan Li, Jia-Yuan Sun, Zhen-Yu He, Juan Zhou
AIM: To evaluate the effect of marital status on survival of patients with vulvar cancer. MATERIALS & METHODS: A total of 4001 patients with vulvar cancer were included from the Surveillance, Epidemiology, and End Results database. Statistical analyses were performed using χ2 test, Kaplan-Meier method, Cox regression proportional hazards and a 1:1 propensity score-matching. RESULTS: The 8-year vulvar cancer-related survival in married, divorced, single and widowed patients were 78...
May 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29742673/trends-in-place-of-death-among-patients-with-gynecologic-cancer-in-the-united-states
#12
Katherine Hicks-Courant, Alexander Melamed, Michael J Worley, Young Bae Kim, John O Schorge, J Alejandro Rauh-Hain
OBJECTIVE: To describe the change over time in place of death (hospital, home, hospice) among all women in the United States who died of gynecologic malignancies and compare them with other leading causes of female cancer deaths. METHODS: This is a retrospective cross-sectional study using national death certificate data from the Mortality Multiple Cause-of-Death Public Use Record Data. All women who died from gynecologic, breast, lung, and colorectal cancers were identified according to International Classification of Diseases, 10 Revision, cause of death from 2003 to 2015...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742668/effects-of-the-affordable-care-act-on-young-women-with-gynecologic-cancers
#13
Anna Jo Bodurtha Smith, Amanda N Fader
OBJECTIVE: To evaluate the effects of the dependent coverage mandate of the 2010 Affordable Care Act (ACA) on insurance status, stage at diagnosis, and receipt of fertility-sparing treatment among young women with gynecologic cancer. METHODS: We used a difference-in-differences design to assess insurance status, stage at diagnosis (stage I-II vs III-IV), and receipt of fertility-spearing treatment before and after the 2010 ACA among young women aged 21-26 years vs women aged 27-35 years...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742173/photodynamic-diagnosis-with-methyl-5-aminolevulinate-in-squamous-intraepithelial-lesions-of-the-vulva-experimental-research
#14
Lea Leufflen, Aurelie Francois, Julia Salleron, Catherine Barlier, Gilles Dolivet, Frederic Marchal, Lina Bezdetnaya
The incidence of the High-grade Squamous Intraepithelial Lesion of the vulva, formerly vulvar intra-epithelial neoplasia is progressively increasing. Today, an early detection and a precise localization of vulvar lesions are still problematic issues, due to the lack of accuracy of the available diagnostic tool. A new approach is the photodynamic diagnosis based on the fluorescence detection of protoporphyrin IX (PpIX) in cancer cells after topical application of a cream of methyl amino-levulinic acid. This study aimed to evaluate the effectiveness of photodiagnosis in order to discriminate the intensity of PpIX fluorescence between vulvar tumor and healthy skin...
2018: PloS One
https://www.readbyqxmd.com/read/29736798/pd-l1-receptor-expression-in-vulvar-carcinomas-is-hpv-independent
#15
M Choschzick, A Gut, D Fink
PD-L1 (programmed cell death 1 ligand) is expressed on many cancer cells and prevents tumor cell death by blocking T cell activity. PD-L1 overexpression has been reported in squamous cell carcinomas of head and neck and lung cancer. To better understand the role of PD-L1 expression in vulvar cancer, we analyzed PD-L1 expression by immunohistochemistry in 55 well-characterized squamous cell carcinomas of vulva. PD-L1 was found in 72.7% of tumors. 27.3% of vulvar carcinomas showed moderate or strong PD-L1 expression...
May 8, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29736362/preoperative-elevated-platelet-count-as-a-prognostic-factor-in-vulvar-squamous-cell-cancer-a-mini-review
#16
REVIEW
Ahmed Abu-Zaid, Osama Alomar, Hany Salem
Preoperative thrombocytosis has been shown to be a marker of advanced disease and poor survival in gynecologic malignancies, specifically endometrial, ovarian, and cervical cancers. The aim of this study is to provide a focused mini-review on all the existing literature concerning the role of preoperative thrombocytosis as a prognostic factor in vulvar squamous cell cancer (SCC). A PubMed search (until February 20, 2018) of all peer-reviewed and English-published articles was conducted using the following keywords: platelet, thrombocytosis, and vulvar cancer...
March 6, 2018: Curēus
https://www.readbyqxmd.com/read/29731205/antenatal-vulvar-pain-management-labour-management-and-postpartum-care-of-women-with-vulvodynia-a-survey-of-physicians-and-midwives
#17
Kelly B Smith, Rosemary Basson, Leslie A Sadownik, Jordanna Isaacson, Lori A Brotto
OBJECTIVE: To examine maternity providers' recommendations for pregnant women with vulvodynia regarding management of vulvar pain and postpartum care, and to examine if, and how, a woman's chronic vulvar pain affects providers' examination and management during labour. METHODS: This research was part of a larger study that invited physicians and midwives to answer a questionnaire regarding pregnancy and childbirth care in women with vulvodynia. To achieve the current objectives, the questionnaire included both dichotomous (yes or no) and open-ended items...
May 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29729932/robotic-video-endoscopic-inguinal-lymphadenectomy-r-veil-for-vulvar-cancer-with-sentinel-node-mapping-using-indocyanine-green-and-near-infrared-fluorescence-imaging-technology
#18
Angelica Naldini, Giuseppe Vizzielli, Emanuele Perrone, Valerio Gallotta, Giovanni Scambia
No abstract text is available yet for this article.
May 3, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29728261/melanoma-of-the-lower-genital-tract-prognostic-factors-and-treatment-modalities
#19
REVIEW
Angiolo Gadducci, Silvestro Carinelli, Maria Elena Guerrieri, Giovanni Damiano Aletti
Primary melanomas originating from the gynecological tract are rare and aggressive cancers. The vulva is the most frequent site (70%), followed by vagina and more rarely by cervix. The clinical outcome of patients with female genital tract melanoma is very poor, with a 5-year overall survival (OS) of 37-50% for vulvar, 13-32% for vaginal, and approximately 10% for cervical melanoma. In this systematic review, we analyzed the pathogenesis and the different factors influencing the prognosis of melanomas of the lower genital tract, with particular emphasis on biologic variables that may influence new therapeutic approaches...
May 1, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29723364/most-frequent-dermatoses-at-a-vulvar-pathology-outpatient-clinic
#20
Gabriella Cerazi Sartori, Rafaela Tricca Wicher, Flávia Regina Ferreira, Valéria Holmo Batista
The vulva corresponds to the external female genitalia. Special features of this region favor a wide range of diseases, whose knowledge allows for better clinical management, impacting on the quality of life. This is a cross-sectional and descriptive study carried out at a vulvar pathology outpatient clinic, between May and December/ 2015. Data obtained from a standard form included demographic parameters, habits, and vulvar dermatosis and allowed to identify the epidemiological profile of patients with vulvar dermatosis treated in this outpatient clinic and to determine the most prevalent dermatoses...
March 2018: Anais Brasileiros de Dermatologia
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