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https://www.readbyqxmd.com/read/29333124/long-term-results-of-radiotherapy-in-vulvar-cancer-patients-in-slovenia-between-1997-2004
#1
Helena Barbara Zobec Logar
Background: The aim of this retrospective single institution study was to analyse long term results of vulvar cancer treatment with conventional 2D radiotherapy in Slovenia between years 1997-2004. Patients and methods: Fifty-six patients, median age 74.4 years +/- 9.7 years, mainly stage T2 or T3, were included in the study. All patients were treated with radiotherapy, which was combined with surgery (group A), used as the primary treatment (group B) or at the time of relapse (group C)...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29327306/strengthening-the-case-for-gender-neutral-and-the-nonavalent-hpv-vaccine
#2
REVIEW
Justin M Hintze, James P O'Neill
PURPOSE: The purpose of this review is to highlight the benefits of gender-neutral and the nonavalent human papillomavirus vaccination. Human papillomavirus infection is the most commonly sexually transmitted disease and is known to cause several types of cancers, including cervical, vulvar, vaginal, penile, oropharyngeal, anal, and rectal. 5% of cancers every year are attributable to human papillomavirus infection, with cervical cancer the most common and oropharyngeal cancer estimated to surpass the incidence of cervical cancer by 2020...
January 11, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29324620/diagnosis-and-treatment-of-vulvar-dermatoses
#3
Colleen K Stockdale, Lori Boardman
Vulvar symptoms of pain, dyspareunia, and pruritus are common and may significantly affect a woman's sense of well-being and sexual function. Despite this, vulvar symptoms are often underreported by women. When identified, however, vulvovaginal symptoms should be addressed by health care providers to optimize care. The evaluation of patients with vulvovaginal complaints begins with a thorough history and physical examination. Biopsy is indicated when concern exists for malignancy or the diagnosis is uncertain...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324545/the-role-of-pathological-margin-distance-and-prognostic-factors-after-primary-surgery-in-squamous-cell-carcinoma-of-the-vulva
#4
Macit Arvas, Ilker Kahramanoglu, Tugan Bese, Hasan Turan, Isik Sozen, Sennur Ilvan, Fuat Demirkiran
OBJECTIVE: The aim of this study was to determine the impact of clear surgical margin distance and other factors associated with the recurrence and survival of patients with squamous cell carcinoma of the vulva. METHODS/MATERIALS: A total of 107 patients operated for vulvar carcinoma from 1996 to 2016 were included in the analysis. Patients were divided into subgroups with clear pathological margin of 2 mm or less, greater than 2 to less than 8 mm, and 8 mm or greater for the analysis of the prognostic impact of the clear margin distance...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29309324/complications-after-vulvar-and-perineal-reconstruction-with-a-lotus-petal-flap
#5
Joke Hellinga, Patrick C K H Khoe, Martin W Stenekes, Yassir Eltahir
BACKGROUND: Lotus petal flaps are often used to reconstruct defects in the vulvoperineal area. Wound complications occur more often after surgery in the vulvoperineal area than in other areas of the body. Postoperative complications have a great impact on patients' well-being, length of hospital stay, care needed, and return to participation in daily life. Therefore, it is important to determine which patients are more prone to develop complications. METHODS: All lotus petal flap reconstructions in our center between January 2004 and August 2014 were retrospectively reviewed...
January 5, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29307625/prognostic-role-of-tumoral-pdl1-expression-and-peritumoral-foxp3-lymphocytes-in-vulvar-melanomas
#6
Agata Chłopik, M Angelica Selim, Yan Peng, Cheng-Lin Wu, Gemma Tell-Marti, Kristen M Paral, Sara C Shalin, Stefan Kraft, Chao-Kai Hsu, Christopher R Shea, Susana Puig, Maria-Teresa Fernandez-Figueras, Wojciech Biernat, Janusz Ryś, Andrzej Marszalek, Mai P Hoang
Prognostic role of PDL1 expression, CD8+ and FoxP3+ lymphocytes in vulvar melanomas has not been studied. We correlated PDL1 expression, and CD8+ and FoxP3+ immune infiltrates with clinicopathologic variables and patient outcomes in a series of 75 vulvar melanomas. Tumoral PDL1 expression (>5%) was seen in 23% of cases. By Fisher's Exact test, PDL1 expression and peritumoral FoxP3+ lymphocytes significantly correlated with less disease-specific death. By linear regression analysis, correlations between tumoral PDL1 expression with the density of tumoral CD8+ and peritumoral CD8+ lymphocytes; tumoral FoxP3+ with tumoral CD8+ lymphocytes; and peritumoral FoxP3+ with peritumoral CD8+ lymphocytes were observed...
January 4, 2018: Human Pathology
https://www.readbyqxmd.com/read/29305965/pediatric-granular-cell-tumors-of-the-vulva-a-report-of-four-cases-and-a-review-of-the-literature
#7
Beryl L Manning-Geist, Antonio R Perez-Atayde, Marc R Laufer
BACKGROUND: Granular cell tumors (GCTs) are rare soft tissue lesions that can involve the female genital tract, including the vulva. While malignant tumors are aggressive and uncommon, benign and atypical lesions still have associated risks, including recurrence and multi-site development. CASES: Four cases of pediatric vulvar GCT are presented, including one atypical and three benign tumors. The atypical lesion occurred in a 3-year-old girl, the youngest reported patient with GCT of the vulva...
January 3, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29303100/-vulvar-angioedema-during-pregnancy
#8
E P Olthof, M R van de Scheur, A E Weis-Potters
BACKGROUND: Angioedema is a condition of acute and extensive fluid accumulation in skin or mucosae due to increased blood vessel permeability. Angioedema can have several causes, including pregnancy. CASE DESCRIPTION: A healthy 33-year-old pregnant woman had acute, substantial swelling of the labia minora with no other symptoms. Based on clinical criteria, angioedema was diagnosed. Laboratory testing did not find any C1 inhibitor deficiency and hereditary angioedema was excluded for that reason...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29302697/-laser-and-light-therapy-for-treatment-of-radiation-dermatitis
#9
REVIEW
H-J Laubach, J Robijns
Radiation dermatitis (RD), an inflammatory skin disease that can be an unwanted side effect of medical radiation therapy (RT), most commonly occurs in patients undergoing cancer of the ENT, anal, and vulvar regions. The side effects on the skin and mucous membranes occur within a few weeks after the initiation of RT; however, late side effects can develop months to years after the RT. Therapeutically, various treatment approaches are considered such as pentoxifylline, hyperbaric oxygen therapy, laser therapy, and PBMT...
January 4, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29299981/normalizers-for-microrna-quantification-in-plasma-of-patients-with-vulvar-intraepithelial-neoplasia-lesions-and-vulvar-carcinoma
#10
Kamil Zalewski, Marcin Misiek, Artur Kowalik, Elwira Bakuła-Zalewska, Janusz Kopczyński, Aleksandra Zielińska, Mariusz Bidziński, Jakub Radziszewski, Stanisław Góźdź, Magdalena Kowalewska
The role of circulating microRNAs as a promising tool for diagnosing cancer and monitoring anticancer therapies has been widely studied in the past decades. To date, no suitable reference microRNAs for normalizing quantitative real-time polymerase chain reaction assays has been identified in vulvar intraepithelial neoplasia lesions and vulvar squamous cell carcinoma. The purpose of this study was to select appropriate references for gene expression studies in plasma of patients with these lesions. Expression levels of six microRNAs-hsa-miR-425-5p, hsa-miR-191-5p, hsa-miR-93-5p, hsa-miR-423-5p, hsa-miR-103a-3p, and hsa-miR-16-5p-were analyzed by quantitative reverse transcription polymerase chain reaction in plasma samples obtained from 17 patients with vulvar intraepithelial neoplasia lesion and 27 patients with vulvar squamous cell carcinoma...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29295880/evaluation-of-ajcc-and-an-alternative-tumor-classification-system-for-primary-vulvar-squamous-cell-carcinoma
#11
Sarah T Le, Pritesh S Karia, Beverley J Vollenhoven, Robert J Besaw, Colleen M Feltmate, Chrysalyne D Schmults
Background: Currently, no studies have attempted to validate the AJCC tumor (T) class for vulvar cancer or examine its performance via clinical data. The goal of this study was to identify risk factors associated with poor outcomes in vulvar squamous cell carcinoma (vSCC) and compare prognostic discrimination of these outcomes between the AJCC T-classification system and the newly developed Brigham and Women's Vulvar Tumor Classification system (BWVTC). Methods: A 15-year, 2-center retrospective cohort study of primary vSCCs (N=226) was undertaken...
January 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29290220/diagnosis-and-management-of-vulvodynia-in-postmenopausal-women
#12
REVIEW
Pedro Vieira-Baptista, Gilbert Donders, Lynnette Margesson, Libby Edwards, Hope K Haefner, Faustino R Pérez-López
Vulvodynia, defined as vulvar pain or burning sensation for more than 3 months, without an identifiable cause, can occur at any age. In this paper, the authors address the classification, epidemiology, etiology, diagnosis, and treatment of this condition, focusing on postmenopausal women. In postmenopausal women, vulvar pain and dyspareunia can often be attributed to low levels of estrogen resulting in vulvovaginal atrophy. While correction of vulvovaginal atrophy is an important part of the management of these patients, it will usually be insufficient to manage vulvodynia...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29277630/vulvar-vesicles-in-an-elderly-female-cutaneous-manifestation-of-a-past-malignancy
#13
Anuradha Bishnoi, Davinder Parsad, Debajyoti Chatterjee
No abstract text is available yet for this article.
December 22, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29274828/mean-medical-costs-associated-with-vaginal-and-vulvar-cancers-for-commercially-insured-patients-in-the-united-states-and-texas
#14
Shuangshuang Fu, David R Lairson, Wenyaw Chan, Chi-Fang Wu, Lois Ramondetta
OBJECTIVE: To estimate the average medical costs for vaginal and vulvar cancers in a commercially insured population in the U.S. and Texas. METHODS: 2011-2014U.S. MarketScan databases were used to estimate the average medical costs associated with vaginal and vulvar cancers. Women with newly diagnosed vaginal or vulvar cancer were matched to a comparison group without cancer using propensity score. Year 1 and year 2 costs after index diagnosis date were estimated...
December 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29258952/5-aminolevulinic-acid-photodynamic-therapy-in-refractory-vulvar-lichen-sclerosus-et-atrophicus-series-of-ten-cases
#15
Ting Lan, Yongzhen Zou, Michael R Hamblin, Rui Yin
BACKGROUND: Vulvar lichen sclerosus et atrophicus (VLSA) is a chronic inflammatory skin disease of unknown etiology that mainly affects postmenopausal and perimenopausal women. The primary clinical symptoms of VLSA are itching, burning pain, and dyspareunia that can results in decreased quality of life. Existing therapies including topical corticosteroid ointment, topical calcineurin inhibitors, estrogens, are not very effective for treatment of VLSA. OBJECTIVE: To evaluate the effectiveness and safety of 5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) in the treatment of VLSA...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29249126/dyspareunia-in-vulvar-lichen-sclerosus-an-overview-of-a-distressing-symptom
#16
Monica Corazza, Annarosa Virgili, Sara Minghetti, Alessandro Borghi
BACKGROUND: Dyspareunia is a symptom of vulvar lichen sclerosus (VLS). This study specifically addressed prevalence and severity of dyspareunia in patients affected with VLS as well as the factors that can influence its occurrence. Changes in the severity of dyspareunia with treatment were also explored. METHODS: In this retrospective, cohort study we included VLS patients who had undergone any topical treatment for 12 weeks, between January 2011 and March 2016, at our Vulva Unit; demographics, history and clinical features recorded at baseline and at treatment completion were elaborated...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29248223/reliability-of-sampling-strategies-for-measuring-dairy-cattle-welfare-on-commercial-farms
#17
Jennifer M C Van Os, Christoph Winckler, Julia Trieb, Soraia V Matarazzo, Terry W Lehenbauer, John D Champagne, Cassandra B Tucker
Our objective was to evaluate how the proportion of high-producing lactating cows sampled on each farm and the selection method affect prevalence estimates for animal-based measures. We assessed the entire high-producing pen (days in milk <100; range = 81-241 cows) on 10 California farms using measures from the Welfare Quality Protocol for Cattle. Cows were restrained in head locks and visually evaluated for body condition, dirtiness, skin alterations (hair loss, lesions, or swelling), discharge (ocular, nasal, vulvar), diarrhea, and impaired respiration...
December 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29240072/-varicose-veins-of-small-pelvis-as-a-cause-of-vulvar-varicosity-and-varicose-veins-of-lower-extremities
#18
REVIEW
S G Gavrilov, M D Temirbolatov
The article is a literature review presenting modern data on applied anatomy of the pelvic veins, diagnosis and treatment of pelvic varicose veins, pelviperineal reflux and vulvar varicosity, lower limb varicose veins, which were caused by pathological reflux from varicose pelvic veins. Presented is the information on tactical approaches in treatment of combined varicose veins of the pelvis and lower limbs, surgical decision-making for correction of pelviperineal reflux, methods of operative and phlebosclerosing interventions on pelvic and superficial veins of the perineum and lower limbs...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29237218/-cylindric-abdominoperineal-rectum-exstirpation-with-partial-vulvar-and-vaginal-resection-as-well-as-perineal-and-vaginal-defect-reconstruction-by-a-vertical-rectus-abdominis-myocutaneous-vram-flap
#19
Christian Krautz, Klaus Weber, Roland Croner, Axel Denz, Matthias Maak, Raymund E Horch, Robert Grützmann
Introduction Patients with low rectal cancer or anal cancer undergoing abdominoperineal excision (APE) benefit from extended surgery and the subsequent avoidance of surgical "waisting" at the level of the puborectalis muscle. The method of cylindrical APE was introduced by T. Holm and led to a reduction of intraoperative perforations and involvement of circumferential resection margins, and subsequently reduced the risk of local recurrence. The use of myocutaneous flaps reduces perineal wound complications, which occur in up to 60% of patients with primary closure of perineal defects, especially following neoadjuvant radiochemotherapy...
December 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29234717/vulvar-lichen-planus-pemphigoides
#20
J Loyal, S Rashtak
Lichen planus pemphigoides (LPP) is a rare blistering disease with features of both lichen planus and bullous pemphigoid. LPP typically appears on the extremities and occasionally involves the oral mucosa. Herein, we describe a case of LPP of the vulva of an 80-year-old woman, an uncommon location for this disease process. This clinical scenario can be confused with a number of similarly appearing entities such as erosive vulvar lichen planus, mucous membrane pemphigoid, and erosive lichen sclerosus et atrophicus...
December 2017: International Journal of Women's Dermatology
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