Read by QxMD icon Read


C Keller, B Mück
We report on an endoscopic triple neurectomy in a female patient with vulvar carcinoma metastasized to the left groin with refractory neuropathic inguinodynia. Using a retroperitoneoscopic approach we resected the ilioinguinal, iliohypogastric, and genitofemoral nerves. The inguinodynia improved significantly; especially the reduced ability to walk was enhanced considerably. Endoscopic triple neurectomy could be a useful therapeutic option in refractory inguinal pain caused by local tumor manifestation.
March 14, 2018: Der Schmerz
Tiffany Zigras, Allan Covens
No abstract text is available yet for this article.
March 9, 2018: Lancet Oncology
Michael Höckel, Sophia Trott, Nadja Dornhöfer, Lars-Christian Horn, Bettina Hentschel, Benjamin Wolf
BACKGROUND: The incidence of vulvar cancer is increasing, but surgical treatment-the current standard of care-often leads to unsatisfactory outcomes, especially in patients with node-positive disease. Preliminary results at our centre showed that locoregional spread of vulvar carcinoma occurs within tissue domains defined by stepwise embryonic and fetal development (ontogenetic cancer fields and associated lymph node regions). We propose that clinical translation of these insights into practice could improve outcomes of surgical treatment of vulvar cancer...
March 9, 2018: Lancet Oncology
Ivan Mañero, Trinidad Labanca
BACKGROUND: Clitoral reconstruction after genital mutilation is a feasible and effective strategy to reduce clitoral pain, improve sexual pleasure, and restore vulvar appearance. TECHNIQUE: We describe a novel surgical technique for clitorolabial reconstruction using a vaginal graft. EXPERIENCE: We present a series of 32 consecutive women who underwent this procedure at Iván Mañero Clinic, Barcelona, Spain, and were prospectively followed...
March 8, 2018: Obstetrics and Gynecology
Emily A Dell, Rachel Y N Miest, Christine M Lohse, Rochelle R Torgerson
Lichen sclerosus (LS) is a chronic inflammatory disease most commonly affecting the genital area of women. LS-associated vulvar neoplasms are known to occur (1). Treatment of LS is thought to possibly reduce malignancy risk. However, whether medical treatment of LS can prevent vulvar neoplasms is unclear (2,3). We performed a single-institution, retrospective chart review to identify vulvar neoplasm occurrence in women with biopsy-proven genital LS and to determine whether a correlation exists between LS treatments and vulvar neoplasm occurrence...
March 10, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Amélie Levesque, Thibault Riant, Stéphane Ploteau, Jérôme Rigaud, Jean-Jacques Labat
Background: The evaluation of chronic pelvic and perineal pain (CPP) is often complex. The patient's description of the pain often appears to be disproportionate to the limited findings on physical examination and/or complementary investigations. The concept of central sensitization may allow better understanding and management of patients with CPP. Objective: The aim of this study was to elaborate a clinical evaluation tool designed to simply identify sensitization in pelvic pain...
March 7, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Aiwen Le, Jie Xiong, Zhonghai Wang, Xiao Yun Dai, Tian Hui Xiao, Rong Zhuo, Ya Hong Xu, Rui Yuan
OBJECTIVE: To explore the feasibility and efficiency of video endoscopic inguinal lymphadenectomy (VEIL) for vulvar cancer. METHODS: We evaluated 46 patients with vulvar cancer. Treatment included VEIL using the hypogastric subcutaneous approach (VEIL-H, 17 patients), VEIL with the limb subcutaneous surgical approach (VEIL-L, 8 patients), and open inguinal lymphadenectomy (OIL, 21 patients). All patients underwent radical vulvectomy; we evaluated operative time, the amount of bleeding, SF score, recurrence rate, etc...
March 8, 2018: Archives of Gynecology and Obstetrics
Xiu-Hua Yang, Feng Guo
The incidence of vulvar squamous cell carcinoma (VSCC) has increased annually over the last decade. MicroRNAs (miRNAs/miRs) serve an important role in tumor progression and development. Our previous microarray studies have revealed that miR‑3147 was overexpressed in VSCC. However, its function and underlying mechanism in VSCC remain unknown. In the present study, it was confirmed by reverse transcription‑quantitative polymerase chain reaction that the expression of miR‑3147 was markedly upregulated in VSCC tissues...
March 7, 2018: Molecular Medicine Reports
Kelly M Tucker, Keshav Godha, Sebastian Mirkin, David F Archer
OBJECTIVE: The aim of the study was to determine the utility of vaginal pH as a marker of menopause and vulvar and vaginal atrophy (VVA) before and after local estrogen treatment. METHODS: Vaginal pH was determined using standard pH paper strips in two clinical trials involving postmenopausal women with signs and symptoms of VVA evaluated before and after intervention with vaginal estradiol in softgel capsules. The utility of vaginal pH was evaluated as a screening method for VVA due to menopause and correlations were analyzed between vaginal pH and VVA symptoms, physical changes, and maturation of the vaginal epithelium...
March 5, 2018: Menopause: the Journal of the North American Menopause Society
Natalia Rakislova, Laia Alemany, Omar Clavero, Marta Del Pino, Adela Saco, Beatriz Quirós, Belen Lloveras, Maria Alejo, Gordana Halec, Wim Quint, Silvia de Sanjosé, Jaume Ordi
Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs) originate from high-grade squamous intraepithelial lesions, also named usual type vulvar intraepithelial neoplasia. However, growing evidence suggests that morphologic studies have limitations in predicting HPV status in vulvar lesions. We aimed to evaluate adjacent intraepithelial lesions in a series of DNA HPV-positive VSCCs, focusing on unusual histologic patterns mimicking differentiated vulvar intraepithelial neoplasia (dVIN) or lichen sclerosus (LS)...
March 2, 2018: American Journal of Surgical Pathology
A Le Fouler, A Hamy, J Barbieux, V Souday, P Bigot, P Le Naoures, R Jaouen, C Brochard, Aurélien Venara
PURPOSE: For survivors of perineal gangrene (PG), quality of life and functional prognosis of pelvic functions are probably overestimated. The aim of this study was to report long-term anal and urinary sphincter dysfunctions, sexual sequelae, and patients' quality of life after treatment of perineal gangrene. METHODS: This retrospective observational study was conducted in one university hospital over 16 years. Seventy-three patients experienced PG; 22 were subject to long-term follow-up...
March 2, 2018: International Journal of Colorectal Disease
X Fritel, B Gachon, D Desseauve, T Thubert
Our main objectives were to identify risk factors, methods for early diagnosis, and prevention of obstetric anal sphincter injuries (OASIs), using a literature review. The main risk factors for OASIs are nulliparity, instrumental delivery, posterior presentation, median episiotomy, prolonged second phase of labor and fetal macrosomia. Asian origin, short ano-vulvar distance, ligamentous hyperlaxity, lack of expulsion control, non-visualization of the perineum or maneuvers for shoulder dystocia also appear to be risk factors...
February 27, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Brandon A Dyer, Abriel Jenshus, Jyoti S Mayadev
INTRODUCTION: Radiation therapy (RT) plays a definitive role in locally advanced vulvar cancer, and in the adjuvant setting with high risk postoperative features after wide local excision. There is significant morbidity associated with traditional, large RT fields using 2D or 3D techniques, and the use of intensity-modulated radiation therapy (IMRT) in vulvar cancer is increasing. However, there remains a paucity of technical information regarding the prevention of a marginal miss during the treatment planning process...
February 28, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Viviane Sant' Anna, Marcelle Railbolt, Aleksandra Oliveira-Menezes, Theodora Calogeropoulou, Jairo Pinheiro, Wanderley de Souza
Alkylphospholipid analogs were initially developed as anticancer agents and were later found to antiparasitic activity. Miltefosine is the prototype alkylphosphocholine and is the first oral treatment against visceral leishmaniasis. Here we investigated the effects of miltefosine and two ring-substituted alkylphosphocholine derivatives, TCAN26 and TC70, on the viability, morphology, and ultrastructure of the life stages of Caenorhabditis elegans and infective larvae of the parasite Strongyloides venezuelensis...
February 26, 2018: Experimental Parasitology
Megha K Trivedi, Carina M Woodruff, Rachel Kornik, Nina Botto
No abstract text is available yet for this article.
February 28, 2018: Dermatitis
Jennifer Muigai, Louis Jacob, Konstantinos Dinas, Karel Kostev, Matthias Kalder
The goal of this study was to estimate a potential delay in the diagnosis of vulvar cancer and identify associated risk factors in women treated in gynecological practices in Germany. The current study sample included 1,652 women from 218 gynecological practices who received an initial diagnosis of vulvar cancer (ICD 10: C51) between January 2000 and December 2015 (index date). After applying several exclusion criteria, 505 non-cancer controls were matched (1:1) to 505 vulvar cancer cases based on age, health insurance status, and index date...
February 2, 2018: Oncotarget
Eric Sven Kroeber, Assefa Mathewos, Tigeneh Wondemagegnehu, Abreha Aynalem, Tufa Gemechu, Swantje Piszczan, Genebo Timotewos, Adamu Addissie, Andreas Wienke, Susanne Unverzagt, Christoph Thomssen, Ahmedin Jemal, Eva Johanna Kantelhardt
Vulvar cancer (VC) is strongly associated with human papilloma virus (HPV) infections and immunosuppression (e.g., HIV). However, there is limited information on VC patient characteristics and survival in parts of sub-Saharan Africa, including Ethiopia, where chronic HPV and HIV infections are prevalent. The aim of this study is to provide a first view on VC patient characteristics in a sub-Saharan African setting.We present a retrospective analysis of records of 86 VC patients diagnosed between January 2010 and October 2015 at Addis Ababa University Hospital and other major health facilities in Ethiopia...
March 2018: Medicine (Baltimore)
Carol Emi Bretschneider, Sarah M Share, Marie Fidela R Paraiso
BACKGROUND: Severe labial agglutination can be refractory to outpatient management and can lead to voiding dysfunction in postmenopausal women. Labial agglutination is often a sequela of long-standing inflammatory processes, which include untreated lichen planus, lichen sclerosus, and atrophic vaginitis. CASE: An 82-year-old parous woman presented with severe labial agglutination and complete obstruction of her vaginal introitus, causing obstructive voiding symptoms...
February 27, 2018: Female Pelvic Medicine & Reconstructive Surgery
Setareh Akhavan, Jila Agah, Fatemeh Nili
A G2L2 33-year-old woman presented to our clinic with large verrucous warty masses in labia major, perinea and the end portion of her spine measuring about 15 × 7, 9 × 7 and 8 × 8 cm, which had been enlarged following puberty and pregnancy. Her right upper and left lower limbs had gross congenital lymphedema. The masses were removed by superficial partial vulvectomy with a qualified margin and repaired without skin graft. Pathology report showed lymphangioma circumscriptum. Several months of follow up revealed normal healing and no recurrence...
February 27, 2018: Journal of Obstetrics and Gynaecology Research
Ilker Kahramanoglu, Hasan Turan, Yahya Ozgun Oner, Tugan Bese, Sennur Ilvan, Macit Arvas, Fuat Demirkiran
Carcinoma of the vulva is usually regarded as a disease of older women, with the typical age of 65-85 years. There are a limited number of reports of vulvar cancer cases younger than 30 years. These patients have usually risk factors such as human papillomavirus (HPV) infection and immunosuppression. Herein, we present a case of invasive squamous vulvar cancer in an 18-year-old patient without any risk factor. Vulvar radical local excision and bilateral inguinal sentinel lymph node biopsies were performed. The clitoris was preserved during the surgery...
2018: Case Reports in Obstetrics and Gynecology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"