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Lung lymphangitic

Hean Ooi, Ching-Yuan Chen, Yu-Chun Hsiao, Wen-Sheng Huang, Bor-Tsung Hsieh
AIM: To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes. PATIENTS AND METHODS: We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardized uptake values (SUVmean and SUVmax, respectively), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were evaluated for their effect on overall survival (OS) and progression-free survival (PFS)...
August 2016: Anticancer Research
Ammaiyappan Chockalingam, Ranganathan Duraiswamy, Madhavan Jagadeesan
BACKGROUND: Bronchoalveolar lavage (BAL) has gained acceptance for diagnosis of Interstitial lung disease (ILD). The advent of high-resolution computed tomography (HRCT) has reduced the clinical utility of BAL. This work has utilized the recommendations of the American Thoracic Society (ATS) to optimize BAL and the findings have been associated with clinical examination and HRCT to precisely narrow down the cause of ILD. MATERIALS AND METHODS: BAL was performed on ILD suspects at the target site chosen based on HRCT...
May 2016: Lung India: Official Organ of Indian Chest Society
Jin Zhao, Ruibin Wu, Yingying Gu
Diffuse pulmonary lymphangiomatosis (DPL) is a rare lymphatic disorder characterized by uncontrolled proliferation of lymphatic vessels. Histologically benign, however, it can lead to death because of its progression. In this paper, we would like to present an unusual case of diffuse pulmonary lymphangiomatosis involving a 28-year-old young female who was suffered chest pain and polypnea for one year, and also a lot of chylous effusion in left chest. Lymphoma and lymphangitic metastasis was the primary diagnosis in other hospitals...
March 2016: Annals of Translational Medicine
Yoshihito Iijima, Hirohiko Akiyama, Maiko Atari, Mitsuro Fukuhara, Yuki Nakajima, Hiroyasu Kinosita, Hidetaka Uramoto
BACKGROUND: Pulmonary metastasectomy has come to be recognized as an effective treatment for selected patients with some malignancies. On the other hand, the role of pulmonary metastasectomy for gastric cancer is still unknown. Metastasectomy is rarely indicated in cases of pulmonary metastasis from gastric cancer, because in most cases, the metastasis occurs in the form of lymphangitic carcinomatosis and the lesions are numerous. The purpose of this study was to determine the surgical outcomes and prognostic factors for survival after pulmonary metastasectomy...
August 23, 2016: Annals of Thoracic and Cardiovascular Surgery
Jennifer Fu, Luan Nguyen, Elise Nguyen, Nick Lau, Ping Ji, Samuel W French, William W Stringer
A 58 year old male with a history of cirrhosis (hepatitis B and C), a long smoking history, and a recently diagnosed high-grade transitional cell carcinoma of the bladder wall presented three days after a biopsy procedure with abdominal pain, nausea, and new hypoxemia on room air. The chest radiograph was clear and the CT angiogram showed only a borderline large pulmonary artery, two small nodules (3mm and 4mm) in the right middle lobe of the lung, and emphysematous changes throughout the lung parenchyma. There was no evidence of pulmonary embolism...
April 2016: Experimental and Molecular Pathology
Dong Soo Lee, Yeon Sil Kim, Chul Seung Kay, Sung Hwan Kim, Chang Dong Yeo, Jin Woo Kim, Seung Joon Kim, Young Kyoon Kim, Yoon Ho Ko, Jin Hyoung Kang, Kyo Young Lee
This study was designed to compare the primary patterns of metastases and clinical outcomes between adenocarcinoma (Adenoca) and squamous cell carcinoma (SQ) in initially diagnosed stage IV non-small cell lung cancer (NSCLC).Between June 2007 and June 2013, a total of 427 eligible patients were analyzed. These patients were histologically confirmed as Adenoca or SQ and underwent systemic imaging studies, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography and brain imaging. Synchronous metastatic sites were categorized into 7 areas, and whole-body metastatic scores were calculated from 1 to 7 by summation of each involved region...
February 2016: Medicine (Baltimore)
Sree Harsha Tirumani, Daniel Souza, Katherine M Krajewski, Jyothi P Jagannathan, Nikhil H Ramaiya, Atul B Shinagare
PURPOSE: To compare the metastatic pattern and outcome of clear cell RCC (ccRCC) and papillary RCC (pRCC), and to assess the impact of sarcomatoid transformation on the disease spread and prognosis. MATERIALS AND METHODS: This IRB-approved, HIPAA-compliant retrospective study included 149 consecutive patients (108 men; mean age 58 years; range 25-86) with metastatic RCC (ccRCC = 116, pRCC = 33), identified from imaging database. All available imaging studies and electronic records of these patients were reviewed to document pathological features, distribution and timing of metastasis, and survival...
February 2016: Abdominal Radiology
Patrick Hensley, Talal Hilal, Janna Neltner, Bharat Kumar
An elderly woman with a history of pulmonary tuberculosis reportedly diagnosed and treated 30 years prior to presentation was found unresponsive at home. Chest imaging revealed innumerable pulmonary nodules worrisome for an infectious process, specifically tuberculosis. The patient deteriorated rapidly and in accordance with her wishes, aggressive interventions were withheld. She died within 48 h from respiratory failure. A limited chest autopsy was performed and revealed the cause of death as lymphangitic spread of cancer from a primary lung adenocarcinoma...
2015: BMJ Case Reports
Chen Zhang, Kevin M Chan, Lindsay A Schmidt, Jeffrey L Myers
BACKGROUND: Pathologic features of end-stage pulmonary sarcoidosis (ESPS) are not well defined; anecdotal reports have suggested that ESPS may mimic usual interstitial pneumonia (UIP). We hypothesized that ESPS has distinct histologic features. METHODS: Twelve patients who received a diagnosis of pulmonary sarcoidosis and underwent lung transplantation were included. Control subjects were 10 age- and sex-matched lung transplant patients with UIP. Hematoxylin and eosin-stained tissue sections were examined for the following features: extent/pattern of fibrosis; presence and quantity (per 10 high-power fields) of fibroblast foci and granulomas; distribution and morphology of granulomas; and presence and extent of honeycomb change...
February 2016: Chest
R Ruffolo, S Suster, M Sivina, M J Robinson
A case of angiosarcoma of the heart with predominant involvement of the pericardium and diffuse bilateral lymphangitic spread to both lungs is presented. The patient was a 32-year-old man admitted for cough, dyspnea, and intermittent hemoptysis. Chest x-ray and computed tomography scans revealed bilateral pulmonary infiltrates and pericardial effusion. An echocardiogram showed a large oval mass overlying and compressing the right atrium and ventricle. At autopsy, multiple hemorrhagic tumor nodules were present in the pericardial sac, and an 8-cm hemorrhagic tumor mass was found overlying and compressing the right atrial appendage and infiltrating the heart muscle...
January 1993: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
Arsineh Khachekian, Sean Shargh, Sarkis Arabian
Pulmonary lymphangitic carcinomatosis (PLC) is the diffuse infltration of lymphatic systems by adenocarcinomas. Because of its vague clinical symptoms and absence of malignant features, confrmatory diagnosis requires transbronchial or open-lung biopsy. Tumor spread is postulated to occur by means of retrograde lymphatic permeation with tumor growth along the lymphatic channels and involvement of vascular endothelial growth factor-C in a signaling pathway. The authors describe the case of a 45-year-old woman whose presentation with cough and dyspnea led to diagnosis of pulmonary lymphangitic carcinomatosis with superimposed pulmonary hypertension, tumor thrombotic microangiopathy, and ultimately metastatic signet ring cell gastric adenocarcinoma...
May 2015: Journal of the American Osteopathic Association
Abhishek Biswas, Peruvemba S Sriram
No abstract text is available yet for this article.
August 2015: American Journal of Medicine
Chang-Min Choi, Mi Young Kim, Hye Jeon Hwang, Jung Bok Lee, Woo Sung Kim
PURPOSE: To study the differences in computed tomographic (CT) characteristics between patients with advanced lung adenocarcinoma who have anaplastic lymphoma kinase (ALK) gene rearrangement and those who have epidermal growth factor receptor (EGFR) mutations. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board. Informed consent was waived. Patients with stage IV adenocarcinoma (n = 198) were enrolled from November 2004 to December 2013, including 68 patients with ALK rearrangement and 130 with EGFR mutation...
April 2015: Radiology
Pelin Cinar, Sarah M Calkins, Alan P Venook, Robin K Kelley
BACKGROUND: Overexpression of the human epidermal growth factor 2 (HER2) is associated with an aggressive metastatic phenotype in patients with breast cancer but its prognostic impact is not well-characterized in gastroesophageal adenocarcinoma. PATIENTS AND METHODS: This is a retrospective series of three cases of HER2-positive gastroesophageal cancer. RESULTS: In this case series, we describe three patients presenting with widespread metastatic disease prior to development of symptoms from the primary tumor...
December 2014: Anticancer Research
Sanjay Mukhopadhyay, Nathan A Pennell, Siraj M Ali, Jeffrey S Ross, Patrick C Ma, Vamsidhar Velcheti
Oncogenic rearrangements of the RET gene have recently been described in 1% to 2% of lung adenocarcinomas. We report five cases of RET-rearranged lung adenocarcinoma with an unusual constellation of clinical and histologic features that has not previously been described in tumors with this genomic alteration. The age at diagnosis of the five patients (4F, 1M) ranged from 44 to 77 years. All were never-smokers. Radiologically, four tumors showed lymphangitic spread within the lungs at presentation; three of these had multiple bilateral lung nodules...
November 2014: Journal of Thoracic Oncology
Ayse Bahadir, Mediha Ortakoylu, Aysun Olcmen, Hasan Akin, Sinem Iliaz, Ibrahim Dincer, Naciye Arda
Bronchology/Interventional Global Case ReportsSESSION TYPE: Global Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Chondrosarcomas are the second most frequent primary malignant bone tumors, after osteosarcomas . They are also the most common primary malignant chest wall tumors. 5-15% of chondrosarcomas are located in the thoracic wall .The most frequent site of metastasis are the lungs; other sites include the bones, brain, regional lymph nodes, and liver . Although, most pulmonary metastases present with multiple peripheral, round nodules of varying size on roentgenograms, certain metastatic sarcomas such as osteosarcomas may have unusual presentation i...
October 1, 2014: Chest
Nabamita Bisen, Vikram Bisen, Subhraleena Das, Robert Lenox
SESSION TITLE: Cancer Case Report Posters ISESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Pulmonary lymphangitic carcinomatosis (PLC) is a rare metastatic lung disease, characterized by infiltration of the pulmonary lymphatic system by tumor cells. We present a case where lymphangitic spread in lungs manifesting as dyspnea and cough, was the primary presentation in a patient with metastatic pancreatic cancer. CASE PRESENTATION: A 61 y...
October 1, 2014: Chest
Rachel Le, Sherry-Ann Brown, Omar Abou-Ezzedine, Darlene Nelson
Miscellaneous Case Report Posters IIISESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Pulmonary hypertension (PH) is the final common pathway for a number of small vessel pulmonary vascular disorders. Defining the underlying mechanism is essential to guide therapies.CASE PRESENTATION: A 43 year old woman with a past medical history of recurrent left breast carcinoma was noted to have an insidious cough, hypoxemia and rapid progression of dyspnea on exertion prompting emergency evaluation...
October 1, 2014: Chest
W-R Lin, R-S Lai
No abstract text is available yet for this article.
November 2014: QJM: Monthly Journal of the Association of Physicians
Li Zhuang, Xiangyan Liu, Chen Hu, Lin Zhang, Guoping Jiang, Jian Wu, Shusen Zheng
Primary liver carcinoma is the most important malignant disease. The nodular metastatic foci of liver carcinoma are usually found in the lung, adrenal gland or abdomen after resection or transplantation. Pulmonary lymphangitic carcinomatosis (PLC) accounts for approximately 6% to 8% of metastatic cancer in the lung. The occurrence of PLC is extremely rare in liver carcinoma. Herein we report the case of a patient with PLC after liver transplantation due to liver carcinoma. PLC was confirmed by clinical manifestations, imaging studies and cytologic examination of exfoliated cells in the pleural effusion...
2014: World Journal of Surgical Oncology
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