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PDE5 AND nephropathy

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https://www.readbyqxmd.com/read/27113485/phosphodiesterase-type-5-inhibition-reduces-albuminuria-in-subjects-with-overt-diabetic-nephropathy
#1
Wim Scheele, Susan Diamond, Jeremy Gale, Valerie Clerin, Nihad Tamimi, Vu Le, Rosalind Walley, Fernando Grover-Páez, Christelle Perros-Huguet, Timothy Rolph, Meguid El Nahas
Diabetic nephropathy (DN) is the leading cause of ESRD worldwide. Reduced bioavailability or uncoupling of nitric oxide in the kidney, leading to decreased intracellular levels of the nitric oxide pathway effector molecule cyclic guanosine monophosphate (cGMP), has been implicated in the progression of DN. Preclinical studies suggest that elevating the cGMP intracellular pool through inhibition of the cGMP-hydrolyzing enzyme phosphodiesterase type 5 (PDE5) might exert renoprotective effects in DN. To test this hypothesis, the novel, highly specific, and long-acting PDE5 inhibitor, PF-00489791, was assessed in a multinational, multicenter, randomized, double-blind, placebo-controlled, parallel group trial of subjects with type 2 diabetes mellitus and overt nephropathy receiving angiotensin converting enzyme inhibitor or angiotensin receptor blocker background therapy...
November 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26497842/erectile-dysfunction-and-its-management-in-patients-with-diabetes-mellitus
#2
Giuseppe Defeudis, Daniele Gianfrilli, Chiara Di Emidio, Riccardo Pofi, Dario Tuccinardi, Andrea Palermo, Andrea Lenzi, Paolo Pozzilli
Diabetes can be described as a syndrome of multiple closely related conditions induced by a chronic state of hyperglycaemia resulting from defective insulin secretion, insulin action or both. Chronic complications associated with diabetes (including neuropathy, vascular disease, nephropathy and retinopathy) are common, and of these, erectile dysfunction (ED) deserves special attention. ED and its correlation with cardiovascular disease require careful evaluation and appropriate treatment. PDE5 inhibitors (PDE5is) are an important tool for the treatment of ED, with new drugs coming onto the market since the late 90s...
October 26, 2015: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/26242375/phosphodiesterase-type-5-inhibitors-and-kidney-disease
#3
REVIEW
Baris Afsar, Alberto Ortiz, Adrian Covic, Abduzhappar Gaipov, Tarik Esen, David Goldsmith, Mehmet Kanbay
Chronic kidney disease (CKD) represents a worldwide health problem. Traditionally, the nephroprotective treatment for CKD aims to slow progression to end-stage renal disease and includes dietary protein restriction, correction of metabolic acidosis, and renin-angiotensin system blockers. However, current standard therapeutic options may not be enough for preventing CKD progression in a subset of patients making necessary to develop novel therapeutic options to further slow renal function loss. Phosphodiesterase type 5 (PDE5) inhibitors represent a class of drugs traditionally used to treat erectile dysfunction and pulmonary hypertension...
September 2015: International Urology and Nephrology
https://www.readbyqxmd.com/read/25426714/sildenafil-citrate-for-prophylaxis-of-nephropathy-in-an-animal-model-of-contrast-induced-acute-kidney-injury
#4
D Adam Lauver, E Grant Carey, Ingrid L Bergin, Benedict R Lucchesi, Hitinder S Gurm
Contrast-induced acute kidney injury (CIAKI) is one of the commonest complications associated with contrast media (CM). Although the exact etiology of CIAKI remains unclear, one hypothesis involves vasoconstriction of afferent arterioles resulting in renal ischemia. Increased renal blood flow, therefore, might represent an attractive target for the treatment of CIAKI. In this study we evaluated the protective effects of the phosphodiesterase type 5 (PDE5) inhibitor, sildenafil citrate, in a rabbit model of CIAKI...
2014: PloS One
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