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Creatinine AND GFR

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https://www.readbyqxmd.com/read/28523356/evaluation-of-height-dependent-and-height-independent-methods-of-estimating-baseline-serum-creatinine-in-critically-ill-children
#1
Erin Hessey, Rami Ali, Marc Dorais, Geneviève Morissette, Michael Pizzi, Nikki Rink, Philippe Jouvet, Jacques Lacroix, Véronique Phan, Michael Zappitelli
BACKGROUND: Baseline serum creatinine (bSCr) is required for diagnosing acute kidney injury (AKI). In children, bSCr is commonly defined as the lowest measurement within 3 months of admission. Measured values are often missing and estimating bSCr using height-based glomerular filtration rate (GFR) equations is problematic when height is unavailable. METHODS: This is a retrospective cohort study including 538 children admitted to the intensive care unit (ICU) between 2003 and 2005 at two centers in Canada, with measured bSCr, height, and ICU-SCr values...
May 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28522656/comparison-between-different-measures-of-body-fat-with-kidney-function-decline-and-incident-ckd
#2
Magdalena Madero, Ronit Katz, Rachel Murphy, Anne Newman, Kushang Patel, Joachim Ix, Carmen Peralta, Suzanne Satterfield, Linda Fried, Michael Shlipak, Mark Sarnak
BACKGROUND AND OBJECTIVES: Although anthropometric measures of body fat are associated with development of CKD, they may not be able to distinguish between various forms of fat and therefore may be less accurate than computed tomography (CT) measures. We compared the association of CT and anthropometric measures of obesity with kidney outcomes in the Health Aging and Body Composition Study. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Participants were recruited from March of 1997 through July of 1998...
May 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28522299/most-advisable-strategy-in-search-of-asymptomatic-target-organ-damage-in-hypertensive-patients
#3
J Abellán-Huerta, L Prieto-Valiente, L Consuegra-Sánchez, S Montoro-García, A B Salguero-Merino, R Morales-López, J Abellán-Alemán, F Soria-Arcos
OBJECTIVE: To evaluate the diagnostic potential of seven examinations in order to define the most suitable strategy for target organ damage (TOD) search in hypertensive patients. METHODS: This is a descriptive, cross-sectional study. 153 consecutive treated and essential hypertensive patients were enrolled. Patients with established cardiovascular or chronic renal disease (stage ≥4) were excluded. TOD search was assessed by: glomerular filtration rate (GFR), albumin/creatinine ratio (ACR), electrocardiogram (ECG), echocardiogram (ECO), ankle-brachial index (ABI), pulse wave velocity (PWV), and carotid ultrasound (intima media thickness and presence of plaques)...
May 15, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28521564/estimating-glomerular-filtration-rate-gfr-in-children-the-average-between-a-cystatin-c-and-a-creatinine-based-equation-improves-estimation-of-gfr-in-both-children-and-adults-and-enables-diagnosing-shrunken-pore-syndrome
#4
Felicia Leion, Josefine Hegbrant, Emil den Bakker, Magnus Jonsson, Magnus Abrahamson, Ulf Nyman, Jonas Björk, Veronica Lindström, Anders Larsson, Arend Bökenkamp, Anders Grubb
Estimating glomerular filtration rate (GFR) in adults by using the average of values obtained by a cystatin C- (eGFRcystatin C) and a creatinine-based (eGFRcreatinine) equation shows at least the same diagnostic performance as GFR estimates obtained by equations using only one of these analytes or by complex equations using both analytes. Comparison of eGFRcystatin C and eGFRcreatinine plays a pivotal role in the diagnosis of Shrunken Pore Syndrome, where low eGFRcystatin C compared to eGFRcreatinine has been associated with higher mortality in adults...
May 19, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28515176/acute-exercise-does-not-impair-renal-function-in-non-dialysis-chronic-kidney-disease-patients-regardless-of-disease-stage
#5
Davi Alves de Santana, Jacques R Poortmans, Egidio L Dorea, Juliana Bannwart de Andrade Machado, Alan L Fernandes, Ana Lúcia de Sá Pinto, Bruno Gualano, Hamilton Roschel
Exercise has been overlooked as a potential therapy in chronic kidney disease (CKD), mainly due to a lack of understanding on its safety aspects. Notably, there is no data on renal function after exercise in CKD considering its stages. We investigated the acute effects of a 30-minute moderate-intensity aerobic exercise bout on glomerular filtration rate (GFR) and albuminuria in twenty-two non-dialysis CKD patients divided into: CKD stages 1 and 2 (CKD1-2) and; CKD stages 3 and 4 (CKD3-4). Eleven body mass index-, age-, and sex-matched healthy individuals served as control (CON)...
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28508095/estimation-of-glomerular-filtration-rate-in-cancer-patients-with-abnormal-body-composition-and-relation-with-carboplatin-toxicity
#6
M Bretagne, A Jouinot, J P Durand, O Huillard, P Boudou Rouquette, C Tlemsani, J Arrondeau, G Sarfati, F Goldwasser, J Alexandre
PURPOSE: Carboplatin clearance is correlated with glomerular filtration rate (GFR) and usually estimated with creatinine clearance using Cockcroft-Gault (CG) formula. Because plasma creatinine level is highly correlated with muscle mass, we hypothesized that an abnormal body composition with a low lean body mass (LBM) percentage [(LBM/weight) × 100] may result in inadequate carboplatin dosing. Serum cystatin C is an alternative marker of GFR, not affected by muscle mass. We aimed to investigate the influence of total LBM and LBM percentage on GFR calculation, using creatinine (CrCl) or cystatin C (GFRcysC-creat) in cancer patients...
May 15, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28507917/systemic-meta-analysis-assessing-the-short-term-applicability-of-early-conversion-to-mammalian-target-of-rapamycin-inhibitors-in-kidney-transplant
#7
Jayant Kumar, Isabella Reccia, Tomokazu Kusano, Bridson M Julie, Ajay Sharma, Ahmed Halawa
AIM: To consolidate the present evidence of effectiveness in renal functioning and graft survival following early introduction of mammalian target of rapamycin (mTOR) inhibitors with or without calcineurin inhibitors (CNIs) in renal transplant recipients. METHODS: We analysed the current literature following PROSPERO approval describing the role of immunosuppressive agent, mTOR inhibitors as an alternative to CNI within six months of renal transplant by searching the PubMed, EMBASE, Cochrane, Crossref, and Scopus using MeSH terms...
April 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28507057/benefit-of-ezetimibe-added-to-simvastatin-in-reduced-kidney-function
#8
John W Stanifer, David M Charytan, Jennifer White, Yuliya Lokhnygina, Christopher P Cannon, Matthew T Roe, Michael A Blazing
Efficacy of statin-based therapies in reducing cardiovascular mortality in individuals with CKD seems to diminish as eGFR declines. The strongest evidence supporting the cardiovascular benefit of statins in individuals with CKD was shown with ezetimibe plus simvastatin versus placebo. However, whether combination therapy or statin alone resulted in cardiovascular benefit is uncertain. Therefore, we estimated GFR in 18,015 individuals from the IMPROVE-IT (ezetimibe plus simvastatin versus simvastatin alone in individuals with cardiovascular disease and creatinine clearance >30 ml/min) and examined post hoc the relationship of eGFR with end points across treatment arms...
May 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28505377/performance-of-glomerular-filtration-rate-estimating-equations-in-a-community-based-sample-of-blacks-and-whites-the-multiethnic-study-of-atherosclerosis
#9
Lesley A Inker, Andrew S Levey, Hocine Tighiouart, Tariq Shafi, John H Eckfeldt, Craig Johnson, Aghogho Okparavero, Wendy S Post, Josef Coresh, Michael G Shlipak
Background.: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations are recommended for glomerular filtration rate (GFR) estimation in the general population. They have not been evaluated in community-based populations, including Blacks at higher levels of GFR, but are commonly applied in such populations. Methods.: In an ancillary study of Multi-Ethnic Study of Atherosclerosis conducted at one site, we evaluated the performance of the CKD-EPI equations for creatinine (eGFRcr), cystatin C (eGFRcys) or the combination (eGFRcr-cys) compared with GFR measured as plasma clearance of iohexol...
May 13, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28504869/kidney-outcomes-in-patients-with-liver-cirrhosis-and-chronic-kidney-disease-receiving-an-orthotopic-liver-transplant-alone
#10
Neeraj Singh, Shahab Ahmadzadeh, Hosein Shokouh-Amiri, Yasir Qazi, Adrian Sequeira, Hrishikesh Samant, Robert McMillan, Gazi B Zibari
Kidney transplant in patients with liver cirrhosis and non-dialysis chronic kidney disease (CKD) is controversial. We report 14 liver cirrhotic patients who had persistently low MDRD-6 estimated-glomerular filtration rate (e-GFR) < 40 ml/min/1.73m2 for ≥ 3 months and underwent either liver transplant alone (LTA) (n=9) or simultaneous liver-kidney transplant (SLKT) (n=5). Pre-transplant, patients with LTA compared with SLKT had lower serum creatinine (2.5±0.73 vs. 4.6±0.52 mg/dl, P= 0.001), higher MDRD-6 e-GFR (21...
May 15, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28501912/idiopathic-retroperitoneal-fibrosis-clinical-features-and-long-term-renal-function-outcome
#11
Mohamed H Zahran, Yasser Osman, Mohamed A Soltan, Ahmed Elhussein Abolazm, Mostafa K Ghazy, Ahmed M Harraz, Ahmed A Shokeir, Hassan Abol-Enein, Bedeir Ali-El-Dein
PURPOSE: To evaluate the long-term renal function outcome of management of retroperitoneal fibrosis (RPF)-induced ureteral obstruction. METHODS: Thirty-six patients with idiopathic RPF-induced ureteral obstruction were classified according to the management type into two groups, group A; managed by indwelling JJ stent and group B managed by ureterolysis and omental wrapping (UOR). The primary outcome was to define the long-term outcome of management on RF. It was evaluated by changes in serum creatinine and estimated GFR (eGFR) using Modification of Diet in Renal Disease equation where 20% changes in eGFR is considered significant...
May 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28497087/renal-function-in-patients-with-diabetic-foot-infection-does-antibiotherapy-affect-it
#12
Roghayeh Akbari, Mostafa Javaniyan, Amir Fahimi, Mahmood Sadeghi
Introduction: Antibiotic treatment (antibiotherapy) of diabetic foot ulcers has been proven to have toxic effect on renal function. Objectives: This study aimed to evaluate renal function in patients with diabetic foot infection. Patients and Methods: This cross-sectional retrospective study was performed on 142 patients with diabetic foot ulcers hospitalized in Shahid Yahyanejad hospital of Babol during 2013. After referring to profile of the patients, they were assigned to participate in two groups: group A consisted of patients receiving antibiotics with a low risk renal toxicity and patients who received antibiotics with a higher risk of renal toxicity were placed in group B...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28497081/relationship-between-serum-irisin-glycemic-indices-and-renal-function-in-type-2-diabetic-patients
#13
Leila Mahmoodnia, Maryam Sadoughi, Ali Ahmadi, Marzieh Kafeshani
Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA1C), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28483464/urinary-albumin-excretion-and-chronic-kidney-disease-in-children-with-vesicoureteral-reflux
#14
Romaine de Sépibus, François Cachat, Blaise J Meyrat, Gezim Dushi, Ariane Boubaker, Mohamed Faouzi, Eric Girardin, Hassib Chehade
BACKGROUND: Albuminuria is a potential biomarker of chronic kidney disease (CKD) in various glomerular diseases. Vesicoureteral reflux (VUR) often progresses to CKD, and study is required of use of albuminuria as a biomarker for this condition. The aim of this study was to evaluate the association between albuminuria and glomerular filtration rate (GFR) or filtration fraction (FF) in children with VUR. STUDY DESIGN: In this retrospective study, renal parameters of 141 children with VUR were investigated, using inulin clearance, FF, and albuminuria...
April 26, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28482048/neither-creatinine-nor-cystatin-c-estimated-glomerular-filtration-rate-is-optimal-in-oncology-patients-treated-with-targeted-agents
#15
Tijl Vermassen, Karen Geboes, Marc De Man, Stéphanie Laurent, Elsie Decoene, Nicolaas Lumen, Joris Delanghe, Sylvie Rottey
Background.: In the last decade, there has been an increase in the use of anti-angiogenic drugs as treatment for metastatic malignancies. However, use of these targeted therapies could induce both glomerular and tubular damage. Also during targeted therapy, the lysosomal protease cathepsin D is released from the tumour, which is inhibited by the protease inhibitor cystatin C. The aim of this study is to determine if use of cystatin C-estimated glomerular filtration rate (eGFR) is applicable to a patient cohort treated with targeted agents...
May 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28480028/a-comparison-of-renal-responses-to-sevoflurane-and-isoflurane-in-patients-undergoing-donor-nephrectomy-a-randomized-controlled-trial
#16
Lady Christine L Ong Sio, Richard Glenn C Dela Cruz, Alexander F Bautista
Sevoflurane and isoflurane are volatile halogenated ether widely used in anesthesia. Both have comparable potency and easy titratability but sevoflurane has lower pungency and results in faster patient recovery. Isoflurane, however, is more affordable. The nephrotoxicity of sevoflurane is undisputed but studies on isoflurane nephrotoxicity are lacking. The objective of this paper is to determine the overall nephrotoxicity profile of sevoflurane and isoflurane in donor nephrectomy patients using the renal function markers - nuclear glomerular filtration rate (GFR), serum creatinine, urine protein-to-creatinine ratio, proteinuria, and glucosuria...
January 2017: Medical Gas Research
https://www.readbyqxmd.com/read/28474735/assessment-of-glomerular-filtration-rate-in-health-and-disease-a-state-of-the-art-review-state-of-the-art-review-for-clinical-pharmacology-and-therapeutics
#17
Andrew S Levey, Lesley A Inker
Acute and chronic kidney diseases affect pharmacokinetics and pharmacodynamics. There has been substantial progress in the past 20 years in the use of GFR estimating equations. In principle, use of a single equation for each filtration marker (creatinine, cystatin C or the combination) for detection, evaluation and management of kidney disease and for drug development and dosing would facilitate clinical practice. We review the principles for assessment of GFR, provide historical perspective and updates regarding use of GFR estimating equations, including assay methods for filtration markers, performance of estimating equations, and recommendations by clinical practice guideline groups and regulatory agencies...
May 5, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28457398/serum-magnesium-and-related-factors-in-long-term-renal-transplant-recipients-an-observational-study
#18
N Rodrigues, A Santana, J Guerra, M Neves, C Nascimento, J Gonçalves, A G da Costa
BACKGROUND: Low serum magnesium (MgS) is a known risk factor for cardiovascular and mineral bone disease. In renal transplant recipients (RTRs), low MgS levels have been related to higher glomerular filtration rates (GFR) and with calcineurin inhibitors, particularly tacrolimus. We aimed to evaluate MgS in renal transplant recipients with over 1 year of follow-up to establish related risk factors and the impact of the use of cyclosporine versus tacrolimus. METHODS: Cross-sectional study of 94 RTRs with more than 12 months of follow-up...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28457076/improvement-in-creatinine-clearance-after-open-heart-surgery-in-infants-as-an-early-indicator-of-surgical-success
#19
Amit Dagan, Ovadia Dagan
BACKGROUND: Early surgical correction of congenital heart malformations in neonates and small infants may be complicated by acute kidney injury (AKI), which is associated with higher morbidity and mortality rates, especially in patients who require dialysis. Glomerular filtration rate (GFR) is considered the best measurement of renal function which, in neonates and infants, is highly dependent on heart function. OBJECTIVES: To determine whether measurements of creatinine clearance after open heart surgery in neonates and young infants can serve as an early indicator of surgical success or AKI...
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28449702/quantification-of-renal-function-following-stereotactic-body-radiotherapy-for-pancreatic-cancer-secondary-dosimetric-analysis-of-a-prospective-clinical-trial
#20
Vivek Verma, Abhijeet R Bhirud, Kyle A Denniston, Nathan R Bennion, Chi Lin
BACKGROUND: This is the first known study examining renal function following stereotactic body radiotherapy (SBRT) for pancreatic head adenocarcinoma. METHODS: Thirty-eight borderline-resectable/unresectable patients, part of an ongoing prospective trial, underwent 3 cycles of gemcitabine/5-fluorouracil followed by SBRT (5 daily fractions of 5/6/7/8 Gy) and concurrent nelfinavir. Thereafter, in resectable cases, surgery was performed within 4-8 weeks. The last available pre-SBRT creatinine was recorded, along with the highest post-SBRT value...
April 27, 2017: Radiation Oncology
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