keyword
MENU ▼
Read by QxMD icon Read
search

Creatinine AND GFR

keyword
https://www.readbyqxmd.com/read/28646178/increased-glomerular-filtration-rate-and-impaired-contractile-function-of-mesangial-cells-in-trpc6-knockout-mice
#1
Weizu Li, Yanfeng Ding, Crystal Smedley, Yanxia Wang, Sarika Chaudhari, Lutz Birnbaumer, Rong Ma
The present study was conducted to determine if TRPC6 regulates glomerular filtration rate (GFR) and the contractile function of glomerular mesangial cells (MCs). GFR was assessed in conscious TRPC6 wild type and knockout mice, and in anesthetized rats with and without in vivo knockdown of TRPC6 in kidneys. We found that GFR was significantly greater, and serum creatinine level was significantly lower in TRPC6 deficient mice. Consistently, local knockdown of TRPC6 in kidney using TRPC6 specific shRNA construct significantly attenuated Ang II-induced GFR decline in rats...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28643485/accuracy-assessment-of-five-equations-used-for-estimating-the-glomerular-filtration-rate-in-korean-adults
#2
Tae Dong Jeong, Eun Jung Cho, Woochang Lee, Sail Chun, Ki Sook Hong, Won Ki Min
BACKGROUND: We aimed to assess the performance of the five creatinine-based equations commonly used for estimates of the glomerular filtration rate (eGFR), namely, the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPIcr), Asian CKD-EPI, revised Lund-Malmö (revised LM), full age spectrum (FAS), and Korean FAS equations, in the Korean population. METHODS: A total of 1,312 patients, aged 20 yr and above who underwent ⁵¹Cr-EDTA GFR measurements (mGFR), were enrolled...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28642453/cystatin-c-based-equation-does-not-accurately-estimate-the-glomerular-filtration-in-japanese-living-kidney-donors
#3
Kazuma Tsujimura, Morihito Ota, Kiyoshi Chinen, Takayuki Adachi, Kiyomitsu Nagayama, Masato Oroku, Morikuni Nishihira, Yoshiki Shiohira, Kunitoshi Iseki, Hideki Ishida, Kazunari Tanabe
BACKGROUND Precise evaluation of a living donor's renal function is necessary to ensure adequate residual kidney function after donor nephrectomy. Our aim was to evaluate the feasibility of estimating glomerular filtration rate (GFR) using serum cystatin-C prior to kidney transplantation. MATERIAL AND METHODS Using the equations of the Japanese Society of Nephrology, we calculated the GFR using serum creatinine (eGFRcre) and cystatin C levels (eGFRcys) for 83 living kidney donors evaluated between March 2010 and March 2016...
June 23, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28623247/evaluation-of-serological-indicators-and-glomerular-filtration-rate-equations-in-chinese-cancer-patients
#4
Yingna Tong, Xiaobin Liu, Mingxiu Guan, Meng Wang, Lufang Zhang, Dong Dong, Ruifang Niu, Fei Zhang, Yunli Zhou
BACKGROUND The performance of estimated glomerular filtration rate (eGFR) have been proved to vary according to the races of the target population. The eGFR equations have not been validated in the Chinese cancer population received chemotherapy. Meanwhile, serum cystatin C (CysC), urea, β2 microglobulin (β2-MG), and creatinine (SCr) were also evaluated in a cohort of Chinese cancer patients. MATERIAL AND METHODS A total of 1000 cancer patients undergoing combination chemotherapy and 108 healthy volunteers were included in this study, and their renal function parameters were evaluated...
June 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28615247/lithium-induced-ndi-acetazolamide-reduces-polyuria-but-does-not-improve-urine-concentrating-ability
#5
Theun de Groot, Joan Doornebal, Birgitte M Christensen, Simone C Cockx, Anne P Sinke, Ruben Baumgarten, Jennifer J Bedford, Robert J Walker, Jack F Wetzels, Peter M T Deen
Lithium is the mainstay treatment for patients with bipolar disorder, but generally causes nephrogenic diabetes insipidus (NDI), a disorder in which the renal urine concentrating ability has become vasopressin-insensitive. Li-NDI is caused by lithium uptake by collecting duct principal cells and downregulation of AQP2 water channels, which are essential for water uptake from pro-urine. Recently, we found that the prophylactic administration of acetazolamide to mice effectively attenuated Li-NDI. To evaluate whether acetazolamide might benefit lithium-treated patients, we administered acetazolamide to mice with established Li-NDI and six patients with a lithium-induced urinary concentrating defect...
June 14, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28602971/new-developments-in-hepatorenal-syndrome
#6
Ayse L Mindikoglu, Stephen C Pappas
Hepatorenal Syndrome (HRS) continues to be one of the major complications of decompensated cirrhosis leading to death in the absence of liver transplantation. Challenges in precisely evaluating renal function in the patient with cirrhosis remain due to the limitations of serum creatinine (Cr) alone in estimating glomerular filtration rate (GFR); current GFR estimating models appear to underestimate renal function. Newer models incorporating renal biomarkers, such as the Cr-Cystatin C GFR Equation for Cirrhosis appear to more accurately estimate true GFR...
June 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28601669/the-diagnostic-value-of-rescaled-renal-biomarkers-serum-creatinine-and-serum-cystatin-c-and-their-relation-with-measured-glomerular-filtration-rate
#7
Hans Pottel, Laurence Dubourg, Elke Schaeffner, Bjørn Odvar Eriksen, Toralf Melsom, Edmund J Lamb, Andrew D Rule, Stephen T Turner, Richard J Glassock, Vandréa De Souza, Luciano Selistre, Karolien Goffin, Steven Pauwels, Christophe Mariat, Martin Flamant, Sebastjan Bevc, Pierre Delanaye, Natalie Ebert
BACKGROUND: Serum creatinine (Scr) is the major contributing variable in glomerular filtration rate (GFR) estimating equations. Serum cystatin C (ScysC) based GFR estimating (eGFR)-equations have also been developed. The present study investigates the relation between 'rescaled' levels of these renal biomarkers (with reference interval of [0.67-1.33]) and measured GFR (mGFR). METHODS: We evaluated the diagnostic ability to detect impaired kidney function of the rescaled renal biomarkers in 8584 subjects from 12 cohorts with measured GFR, standardized Scr and ScysC...
June 7, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28601121/relationship-between-subendocardial-viability-ratio-and-hemoglobin-in-patients-with-chronic-kidney-disease
#8
Robert Ekart, Sebastjan Bevc, Nina Hojs, Tina Stropnik Galuf, Martin Hren, Benjamin Dvoršak, Maša Knehtl, Eva Jakopin, Igor Krajnc, Radovan Hojs
AIMS: Pulse wave analysis (PWA) uses the technique of applanation tonometry to obtain a peripheral pulse pressure waveform from which central hemodynamic information is derived. Using PWA, subendocardial viability ratio (SEVR) can be measured. SEVR represents a noninvasive measure of myocardial perfusion. It is related to the work of the heart, the oxygen consumption, and the energy supply of the heart. Anemia is a common complication of chronic kidney disease (CKD). A complex relationship exists between CKD, cardiovascular disease (CVD), and anemia...
June 9, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28589217/a-prospective-randomized-comparison-of-micropercutaneous-nephrolithotomy-microperc-and-retrograde-intrarenal-surgery-rirs-for-the-management-of-lower-pole-kidney-stones
#9
Abdulkadir Kandemir, Selcuk Guven, Mehmet Balasar, Mehmet Giray Sonmez, Hakan Taskapu, Recai Gurbuz
OBJECTIVE: To make a comparison between the safety and efficacy of micropercutaneous nephrolithotomy (microperc) and retrograde intrarenal surgery (RIRS) for the management of lower pole kidney stones up to 15 mm. PATIENTS AND METHODS: 60 patients presenting with solitary lower pole kidney stones up to 15 mm were included in the study between March 2013 and December 2015. Patients were randomized into Microperc or RIRS groups with computer-generated numbers. RESULTS: The mean stone size was 10...
June 6, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28587950/anemia-considerations-when-assessing-natriuretic-peptide-levels-in-ed-patients
#10
Inanc Karakoyun, Ayfer Colak, Fatma Demet Arslan, Aybike Gunaslan Hasturk, Can Duman
INTRODUCTION: The incidence of heart failure (HF) has reached epidemic levels in western populations, and the majority of these patients are admitted to hospitals through the emergency department (ED). We aimed to aid clinicians assessing natriuretic peptide (NP) levels in cases with suspected HF. In this study, we investigated the effect of anemia on amino-terminal pro-BNP (NT-proBNP) and on B-type natriuretic peptide (BNP) levels. METHODS: This retrospective study examined patients who were admitted to the ED with suspected HF...
May 31, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28586363/preoperative-serum-cystatin-c-as-a-potential-biomarker-for-prognosis-of-renal-cell-carcinoma
#11
Shengjie Guo, Yunfei Xue, Qiuming He, Xiaobo He, Kunbin Guo, Pei Dong, Kai Yao, Guangwei Yang, Dong Chen, Zaishang Li, Xiangdong Li, Zike Qin, Zhuowei Liu, Wenjie Cheng, Chao Guo, Meng Zhang, Hui Han, Fangjian Zhou
PURPOSE: The prognostic value of serum cystatin-C (Cys-C) in renal cell carcinoma (RCC) remains unknown. The purpose of this study is to explore the prognostic value of Cys-C for RCC patients. PATIENTS AND METHODS: The levels of preoperative Cys-C, creatinine (CRE) and estimated glomerular filtration rate (e-GFR) were retrospectively collected in 325 RCC patients undergoing surgery. The cutoff values of Cys-C, CRE and e-GFR were determined by the standardized Cutoff Finder algorithm...
2017: PloS One
https://www.readbyqxmd.com/read/28583565/role-of-urinary-neutrophil-gelatinase-associated-lipocalin-for-predicting-the-severity-of-renal-functions-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#12
K Vareesangthip, K Vareesangthip, C Limwongse, K Reesukumal
BACKGROUND: Autosomal-dominant polycystic kidney disease (ADPKD) has a feature of disruption of tubular integrity with increased cellular proliferation and apoptosis. There are several known tubular membrane proteins in the pathogenesis of ADPKD, and one of these proteins is the neutrophil gelatinase-associated lipocalin (NGAL). NGAL is a protein expressed on renal tubular cells of which production is markedly increased in response to harmful stimuli such as ischemia or toxicity. OBJECTIVE: We aim to study whether urinary NGAL levels could be used as a marker to identify the severity of ADPKD in patients...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28583518/cystatin-c-based-equation-for-predicting-the-glomerular-filtration-rate-in-kidney-transplant-recipients
#13
Y Yang, K Y Kim, I Hwang, T Yim, W Do, M J Kim, S Lee, H-Y Jung, J-Y Choi, S-H Park, Y-L Kim, C-D Kim, J-H Cho
BACKGROUND: Precise monitoring of the glomerular filtration rate (GFR) is needed to estimate the allograft function in kidney transplant recipients (KTRs). The GFR is widely estimated with the use of formulas based on serum cystatin C (SCys) and serum creatinine (SCr) levels. We compared the efficacy of SCys-based equations with that of SCr-based equations to predict the allograft function. METHODS: We calculated the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI Cr), CKD-EPI creatinine-cystatin C (CKD-EPI Cr/Cys), and CKD-EPI cystatin C (CKD-EP ICys) equations in 70 KTRs...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28581186/prevalence-of-chronic-kidney-disease-in-patients-with-chronic-hepatitis-b-a-cross-sectional-survey
#14
Ling Ning, Weiyin Lin, Xiaoyun Hu, Fan Rong, Xieer Liang, Yaobo Wu, Sheng Shen, Rui Yu, Jian Sun, Jinlin Hou
Renal safety is a major concern during long-term antiviral treatment for chronic hepatitis B (CHB). This study aimed to investigate the prevalence of chronic kidney disease (CKD) in patients with CHB that had been treated with antiviral therapy. This was a single center, cross-sectional study in a real-life cohort in which all patients received antiviral treatment. Serum creatinine-based equations from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) were used to estimate the glomerular filtration rate (GFR)...
June 5, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28578426/prevalence-of-chronic-kidney-disease-markers-evidence-from-a-three-million-married-population-with-fertility-desire-in-rural-china
#15
Ye Du, Shikun Zhang, Mei Hu, Qiaomei Wang, Haiping Shen, Yiping Zhang, Donghai Yan, Yuanyuan Li, Man Zhang, Qun Meng
We aimed to assess the prevalence of chronic kidney diseases (CKD) markers among the married residents with fertility desire in rural China. Demographic and clinical data were collected from the National Free Pre-Conception Health Examination Project. Estimated glomerular filtration rate (eGFR) < 60 mL/min//1.73 m(2), proteinuria, and hematuria were defined as markers of CKD. GFR was evaluated by using serum creatinine level and the Asian-modified CKD epidemiology collaboration equation. Automated urine dry chemical and microscopic analyses were employed to identify proteinuria and hematuria...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28573537/derivation-of-new-equations-to-estimate-glomerular-filtration-rate-in-pediatric-oncology-patients
#16
Vanessa E Millisor, Jessica K Roberts, Yilun Sun, Li Tang, Vinay M Daryani, David Gregornik, Shane J Cross, Deborah Ward, Jennifer L Pauley, Alejandro Molinelli, Rachel C Brennan, Clinton F Stewart
BACKGROUND AND OBJECTIVE: Monitoring renal function is critical in treating pediatric patients, especially when dosing nephrotoxic agents. We evaluated the validity of the bedside Schwartz and Brandt equations in pediatric oncology patients and developed new equations for estimated glomerular filtration rate (eGFR) in these patients. METHODS: A retrospective analysis was conducted comparing eGFR using the bedside Schwartz and Brandt equations to measured GFR (mGFR) from technetium-99m diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) between January 2007 and August 2013...
June 2, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28573142/advances-in-the-diagnosis-and-treatment-of-acute-kidney-injury-in-cirrhosis-patients
#17
REVIEW
Lei Lei, Liangping Li, Hu Zhang
Liver cirrhosis is a common progressive and chronic clinical liver disease. Due to the strong compensation ability of the liver, no obvious symptoms develop in the early stage. However, multiple systems are involved in decompensation of the liver. Acute kidney injury (AKI) is one of the most serious complications, characterized by a sharp drop in the glomerular filtration rate (GFR); a rapid increase in Scr and BUN, as well as sodium and water storage; and a disturbance of acid-base balance. The mortality rate is high, and the prognosis is very poor...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28571128/association-between-serum-cystatin-c-and-creatinine-in-chronic-kidney-disease-subjects-attending-a-tertiary-health-care-centre
#18
Janice DSa, Sukanya Shetty, Roopa Rani Bhandary, Ashalatha V Rao
INTRODUCTION: Chronic Kidney Disease (CKD) is an emerging health problem due to the increasing prevalence of conditions like diabetes mellitus and hypertension. Most patients are diagnosed during the later stages of CKD when the clinical symptoms become apparent. There is a need for early diagnosis to prevent disease progression and associated morbidities. Serum Creatinine (SCr) is commonly used among clinicians to determine renal function. However, SCr is affected by several factors and cannot be entirely relied upon...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28570649/antioxidant-agents-for-delaying-diabetic-kidney-disease-progression-a-systematic-review-and-meta-analysis
#19
Davide Bolignano, Valeria Cernaro, Guido Gembillo, Rossella Baggetta, Michele Buemi, Graziella D'Arrigo
BACKGROUND: Oxidative stress is a key player in the genesis and worsening of diabetic kidney disease (DKD). We aimed at collecting all available information on possible benefits of chronic antioxidant supplementations on DKD progression. STUDY DESIGN: Systematic review and meta-analysis. POPULATION: Adults with DKD (either secondary to type 1 or 2 diabetes mellitus). SEARCH STRATEGY AND SOURCES: Cochrane CENTRAL, Ovid-MEDLINE and PubMed were searched for randomized controlled trials (RCTs) or quasi-RCTs without language or follow-up restriction...
2017: PloS One
https://www.readbyqxmd.com/read/28569557/effects-of-acute-blood-pressure-elevation-on-biochemical-metabolic-parameters-in-individuals-with-hypertensive-crisis
#20
Days Oliveira Andrade, Sara Patrícia O Santos, Marcela Augusta S Pinhel, Flávia Mariana Valente, Marcela Cavichiolo Giannini, Michele Lima Gregório, Moacir Fernandes De Godoy, Dorotéia Rossi S Souza, José Fernando Vilela-Martin
Hypertensive crisis is a common clinical situation that presents a high rate of morbidity and mortality and it is characterized by symptomatic rise of blood pressure (BP), systolic (SBP) ≥ 180 mmHg and/or diastolic (DBP) ≥ 120 mmHg. It is classified as emergency (HE) or hypertensive urgency (HU). There is no description of laboratory findings in patients who present acute BP elevation. Thus, this study had the objective to assess the biochemical-metabolic parameters of patients with HC. We studied 74 normotensive individuals (NT), 74 controlled hypertensive patients (ContrHT), 50 subjects with HU, and 78 with HE for evaluating biochemical-metabolic parameters...
June 1, 2017: Clinical and Experimental Hypertension: CHE
keyword
keyword
92626
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"