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ulcerative colitis sleep

Aleksandra Sobolewska-Włodarczyk, Marcin Włodarczyk, Janusz Szemraj, Krystyna Stec-Michalska, Jakub Fichna, Maria Wiśniewska-Jarosińska
Crohn's disease (CD) and ulcerative colitis (UC) are the main representatives of inflammatory bowel diseases (IBD), a group of chronic, immune system-mediated inflammatory diseases of the gastrointestinal (GI) tract. The pathogenesis of the intestinal lesions in IBD is not entirely identified and understood: excessive activation of the immune system may come as a result of the interaction of various environmental and infectious factors, genetic predisposition, and the mediation of abnormal intestinal flora...
August 2016: Pharmacological Reports: PR
Matthew Geisz, Christina Ha, Michael D Kappelman, Christopher F Martin, Wenli Chen, Kristen Anton, Robert S Sandler, Millie D Long
BACKGROUND: Older individuals with inflammatory bowel disease (IBD) require ongoing medications. We aimed to describe (1) medication use in older and younger IBD patients and (2) medication associations with patient reported outcomes (PROs) in older patients. METHODS: We conducted cross-sectional and longitudinal analyses within CCFA Partners internet-based cohort of patients with self-reported IBD. We assessed medication use by disease sub-type and age. We used bivariate analyses to (1) compare medication use in older and younger patients and (2) determine associations between continued steroid use and patient reported outcomes in older patients...
June 2016: Inflammatory Bowel Diseases
Evangelia Legaki, Maria Gazouli
Idiopathic inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), are multifactorial diseases that are manifested after disruption of a genetic predisposed individual and its intestinal microflora through an environmental stimulus. Urbanization and industrialization are associated with IBD. Epidemiological data, clinical observations and family/immigrants studies indicate the significance of environmental influence in the development of IBD. Some environmental factors have a different effect on the subtypes of IBD...
February 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
Makoto Tanaka, Aki Kawakami, Yasushi Iwao, Tsuneo Fukushima, Noriko Yamamoto-Mitani
The study objective was to investigate the nature and perceived effectiveness of strategies that patients with inflammatory bowel disease (IBD) use in response to worsening symptoms. Questionnaires to investigate the use and perceived effectiveness of 11 types of strategies for coping with possible flare-ups were mailed to 1,641 members of the Crohn's and Colitis Foundation of Japan. The responses were analyzed separately by disease type: ulcerative colitis (UC) and Crohn disease (CD). A total of 400 questionnaires were analyzed from 260 UC and 140 CD patients...
January 2016: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
Ker Kan Tan, Ragavan Manoharan, Saissan Rajendran, Praveen Ravindran, Christopher J Young
INTRODUCTION: The aim of the study was to determine if age at the creation of an ileal pouchanal anastomosis (IPAA) has an impact on the outcomes in patients with ulcerative colitis (UC). MATERIALS AND METHODS: A retrospective review of all patients who underwent IPAA for UC from 1999 to 2011 was performed. Long-term functional outcome was assessed using both the Cleveland Clinic and St Mark's incontinence scores. RESULTS: Eighty-nine patients, with a median age of 46 (range, 16 to 71) years, formed the study group...
March 2015: Annals of the Academy of Medicine, Singapore
Ashwin N Ananthakrishnan
IBD, comprising Crohn's disease and ulcerative colitis, is a chronic immunologically mediated disease at the intersection of complex interactions between genetics, environment and gut microbiota. Established high-prevalence populations of IBD in North America and Europe experienced the steepest increase in incidence towards the second half of the twentieth century. Furthermore, populations previously considered 'low risk' (such as in Japan and India) are witnessing an increase in incidence. Potentially relevant environmental influences span the spectrum of life from mode of childbirth and early-life exposures (including breastfeeding and antibiotic exposure in infancy) to exposures later on in adulthood (including smoking, major life stressors, diet and lifestyle)...
April 2015: Nature Reviews. Gastroenterology & Hepatology
M Storr
No abstract text is available yet for this article.
December 15, 2014: MMW Fortschritte der Medizin
Andrei Keidar, David Hazan, Eran Sadot, Hanoch Kashtan, Nir Wasserberg
BACKGROUND: Bariatric surgery is considered as being contraindicated for morbidly obese patients who also have inflammatory bowel disease (IBD). The aim of our study was to report the outcomes of bariatric surgery in morbidly obese IBD patients. METHODS: The prospectively collected data of all the patients diagnosed as having IBD who underwent bariatric operations in 2 medical centers between October 2006 and January 2014 were retrieved and analyzed. RESULTS: One male and 9 female morbidly obese IBD patients (8 with Crohn's disease and 2 with ulcerative colitis) underwent bariatric surgery...
January 2015: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Parth J Parekh, Edward C Oldfield Iv, Vaishnavi Challapallisri, J Catsby Ware, David A Johnson
Sleep dysfunction is a highly prevalent condition that has long been implicated in accelerating disease states characterized by having an inflammatory component such as systemic lupus erythematosus, HIV, and multiple sclerosis. Inflammatory bowel disease (IBD) is a chronic, debilitating disease that is characterized by waxing and waning symptoms, which are a direct result of increased circulating inflammatory cytokines. Recent studies have demonstrated sleep dysfunction and the disruption of the circadian rhythm to result in an upregulation of inflammatory cytokines...
April 2015: American Journal of Gastroenterology
Aoibhlinn O'Toole, Joshua Korzenik
The fundamental elucidation of how environmental influences provoke the initiation of disease as well as flares of inflammatory bowel disease (IBD) remains incomplete. The current understanding of these diseases suggests that ulcerative colitis (UC) and Crohn's disease (CD) result from poorly defined interactions between genetic and environmental factors which culminate in the pathologic effects and clinical manifestations of these diseases. The genetic variant appears not sufficient itself to lead to the development of the clinical disease, but likely must combine with the environmental factors...
2014: Current Gastroenterology Reports
Ashwin N Ananthakrishnan, Hamed Khalili, Gauree G Konijeti, Leslie M Higuchi, Punyanganie de Silva, Charles S Fuchs, James M Richter, Eva S Schernhammer, Andrew T Chan
BACKGROUND & AIMS: Sleep deprivation is associated with production of inflammatory cytokines. Disturbed sleep quality has been associated with increased risk of disease flare in patients with Crohn's disease (CD) or ulcerative colitis (UC). However, the association between sleep and risk of incident CD and UC has not been previously examined. METHODS: We conducted a prospective study of women who were enrolled in the Nurses' Health Study (NHS) I since 1976 and NHS II since 1989 and followed through detailed biennial questionnaires with >90% follow-up...
November 2014: Clinical Gastroenterology and Hepatology
Branislav R Filipovic, Branka F Filipovic
Ulcerative colitis and Crohn's disease, commonly known as inflammatory bowel disease (IBD), draw attention from specialists of various disorders, including gastroenterology, psychiatry, and radiology. The involvement of a cortical influence in the brain-gut axis as well as the interaction of the hypothalamic-pituitary-adrenal axis and the peripheral nervous system provide an initial explanation of the psychological symptoms associated with IBD. The involvement of structures the limbic system, such as the anterior cingulate cortex, the prefrontal cortex, and the amygdala, paves the way for the discovery of the mechanisms underlying depression depression, anxiety, alexithymia, personality traits, and other psychological impairments following the onset of IBD...
April 7, 2014: World Journal of Gastroenterology: WJG
Eric K Nakakura
No abstract text is available yet for this article.
May 2014: JAMA Surgery
Francisco J Martínez-Orozco, José L Vicario, Isabel Villalibre-Valderrey, Clara De Andrés, Miguel Fernández-Arquero, Rosa Peraita-Adrados
Evidence suggests that autoimmune diseases tend to co-occur so that patients with an autoimmune disorder are at higher risk of a second autoimmune disease. The association between allergic and autoimmune diseases is also of considerable interest. There are no reports on the association between sporadic or familial narcolepsy with cataplexy and other non-neurological immune-mediated diseases. This study reported on the comorbid immunopathological diseases associated with narcolepsy. One-hundred and fifty six narcoleptic patients with a mean age at diagnosis of 39...
August 2014: Journal of Sleep Research
Pan Yan, Ouyang Qin
OBJECTIVE: To investigate the efficacy and mechanisms of Bawei Xilei Powder (BXP) in treating ulcerative colitis (UC). METHODS: Totally 103 patients with left hemicolon mild to moderate UC in the active phase at the outpatient clinics of West China Hospital from June 2009 to October 2010 were randomly assigned to the treatment group (55 cases) and the control group (48 cases). Patients in the treatment group were treated with BXP (adding 1 g in 60 mL worm boiled water) and those in the control group received by 50 mg/60 mL hydrocortisone edema solution (once every evening before sleep)...
January 2014: Chinese Journal of Integrated Traditional and Western Medicine
Tomohisa Takagi, Yutaka Inada, Yuji Naito
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic and recurrent inflammatory disorder of the intestinal tract. It has been demonstrated that sleep disturbances are involved in the pathogenesis of the patients with IBD. In addition, it has been shown that melatonin, which is a hormone produced by the pineal gland and maintains circadian rhythm, plays an important role as regulators of inflammation as well as a player in proper immune system and antioxidant system in the intestinal disorders...
December 2013: Nihon Rinsho. Japanese Journal of Clinical Medicine
Daniel R van Langenberg, Peter R Gibson
BACKGROUND: Fatigue commonly impairs quality of life in patients with Crohn's disease (CD). This study aimed to evaluate the prevalence and severity of fatigue in CD (compared with ulcerative colitis [UC] and healthy controls) and to identify potentially modifiable factors associated with global, physical, and cognitive dimensions of fatigue. METHODS: Clinic attendees with confirmed CD or UC and healthy volunteers were surveyed on fatigue (Fatigue Impact Scale, FIS), psychological comorbidity, sleep quality, medication, and other clinical information...
January 2014: Inflammatory Bowel Diseases
Michael D Kappelman, Millie D Long, Christopher Martin, Darren A DeWalt, Patricia M Kinneer, Wenli Chen, James D Lewis, Robert S Sandler
BACKGROUND & AIMS: Patient-reported outcomes (PROs) convey important aspects of health status, complementing physician-reported measures. The PRO Measurement Information System (PROMIS) provides valid, widely available measures applicable to patients with chronic illness and the general population. We sought to evaluate these measures in a large cohort of patients with inflammatory bowel disease (IBD). METHODS: By using data from the Crohn's and Colitis Foundation Association Partners internet cohort, we performed cross-sectional and longitudinal analyses to evaluate associations between PROMIS measures and validated disease activity indices (Short Crohn's Disease Activity Index and Simple Clinical Colitis Activity Index) and the Short IBD Questionnaire quality-of-life instrument...
August 2014: Clinical Gastroenterology and Hepatology
Tauseef Ali, Mohammad F Madhoun, William C Orr, David T Rubin
PURPOSE: Poor sleep quality is associated with adverse health consequences. Sleep disturbances can impact the immune function and process of inflammation. The relationship between sleep quality and the inflammatory bowel disease (IBD) has not been well studied. METHODS: A prospective observational cohort study was performed to assess the correlation of the quality of sleep and disease activity in IBD. We used the Pittsburgh Sleep Quality Index (PSQI) to measure sleep quality...
October 2013: Inflammatory Bowel Diseases
Charles N Bernstein, Eran Israeli
No abstract text is available yet for this article.
August 2013: Clinical Gastroenterology and Hepatology
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