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JOURNAL ARTICLE
Alex Martino Cinnera, Giovanni Morone, Marco Iosa, Stefano Bonomi, Rocco Salvatore Calabrò, Paolo Tonin, Antonio Cerasa, Alessandro Ricci, Irene Ciancarelli
BACKGROUND AND AIM: Lumbar spinal stenosis (LSS) is a leading cause of low back pain and lower limbs pain often associated with functional impairment which entails the loss or the impairment of independence in older adults. Conservative treatment is effective in a small percentage of patients, while a significant percentage undergo surgery, even if often without a complete resolution of clinical symptoms and motor deficits. The aim of the study is to identify clinical and demographic prognostic factors characterising the patients who would benefit most from surgical treatment in relation to the functional independence recovery using an innovative approach based on an artificial neural network...
September 2024: Journal of Orthopaedics
#2
JOURNAL ARTICLE
Judith Jud, Harald Stefanits, Ellen Gelpi, Valérie Quinot, Susanne Aull-Watschinger, Thomas Czech, Christian Dorfer, Karl Rössler, Christoph Baumgartner, Gregor Kasprian, Clara Watschinger, Doris Moser, Jonas Brugger, Ekaterina Pataraia
BACKGROUND: We aimed to analyze potentially prognostic factors which could have influence on postoperative seizure, neuropsychological and psychiatric outcome in a cohort of patients with mesial temporal lobe epilepsy (MTLE) due to hippocampal sclerosis (HS) after selective amygdalohippocampectomy (SAHE) via transsylvian approach. METHODS: Clinical variables of 171 patients with drug-resistant MTLE with HS (88 females) who underwent SAHE between 1994 and 2019 were evaluated using univariable and multivariable logistic regression models, to investigate which of the explanatory parameters can best predict the outcome...
April 15, 2024: Journal of Neurology
#3
JOURNAL ARTICLE
Maria Heinrich, Claudia Spies, Friedrich Borchers, Insa Feinkohl, Tobias Pischon, Arjen J C Slooter, Clarissa von Haefen, Norman Zacharias, Georg Winterer, Florian Lammers-Lietz
Past studies have observed that brain atrophy may accelerate after surgical procedures. Furthermore, an association of systemic inflammation with neurodegeneration has been described. We hypothesize that postoperative interleukin (IL) levels in circulation as well as the perioperative change in interleukin levels are associated with increased postoperative atrophy in the Nucleus basalis magnocellularis (of Meynert, NBM) which is the major source of cortical acetylcholine. We analyzed data from the BioCog cohort which included patients ≥ 65 years presenting for elective major surgery (≥ 60min)...
March 14, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
#4
REVIEW
Julia Yu, Matthew R Petersen, Lauren E Meece, Eric I Jeng, Mohammad A Al-Ani, Alex M Parker, Juan R Vilaro, Juan M Aranda, Mustafa M Ahmed
The prognostic implication of cognitive frailty assessment in patients undergoing left ventricular assist device (LVAD) implantation remains unclear. We conducted a systematic review to evaluate assessment strategies and their significance for patients undergoing LVAD implantation. A comprehensive search of PubMed, Embase, and the Cumulative Index to Nursing and Allied Health Literature from inception until September 2022 and a review of meeting proceedings were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
January 10, 2024: Geriatrics & Gerontology International
#5
JOURNAL ARTICLE
Ting-An Cheng, Po-Hsuan Lai, Hao-Chun Chuang, Kai-Lan Hsu, Fa-Chuan Kuan, Wei-Ren Su, Chih-Kai Hong
INTRODUCTION: Geriatric fractures including distal femur and hip fractures are associated with high mortality rates. Currently, prognostic factors for in-hospital postoperative mortality are not identified. We aimed to evaluate overall in-hospital mortality and related potential risk factors in elderly patients who underwent distal femur fracture surgery. MATERIALS AND METHODS: A retrospective cohort study of patients older than 60 years, who underwent distal femur fracture surgery between January 01, 2003, and December 31, 2021, was conducted...
2023: SICOT-J
#6
COMMENT
Evangelia Liouta, Christos Koutsarnakis, Spyridon Komaitis, Aristotelis V Kalyvas, Evangelos Drosos, Juan M García-Gómez, Javier Juan-Albarracín, Vasileios Katsaros, Lampis Stavrinou, George Stranjalis
BACKGROUND: Aim of the present study is to investigate whether preoperative neurocognitive status is prognostically associated with overall survival (OS) in newly diagnosed glioblastoma (GBM) patients. METHODS: Ninety patients with dominant-hemisphere IDH-wild-type GBM were assessed by Mini Mental Status Exam (MMSE), Trail Making Test (TMT) A and B parts, and Control Word Association Test (COWAT) phonemic and semantic subtests. Demographics, Karnofsky Performance Scale, tumor parameters, type of surgery, and adjuvant therapy data were available for patients...
December 2023: Neuro-oncology Practice
#7
REVIEW
César Fernández-de-Las-Peñas, Lidiane L Florencio, Ana I de-la-Llave-Rincón, Ricardo Ortega-Santiago, Margarita Cigarán-Méndez, Stella Fuensalida-Novo, Gustavo Plaza-Manzano, Lars Arendt-Nielsen, Juan A Valera-Calero, Marcos J Navarro-Santana
Knee and hip osteoarthritis are highly prevalent in the older population. Management of osteoarthritis-related pain includes conservative or surgical treatment. Although knee or hip joint replacement is associated with positive outcomes, up to 30% of patients report postoperative pain in the first two years. This study aimed to synthesize current evidence on prognostic factors for predicting postoperative pain after knee or hip replacement. An umbrella review of systematic reviews was conducted to summarize the magnitude and quality of the evidence for prognostic preoperative factors predictive of postoperative chronic pain (>6 months after surgery) in patients who had received knee or hip replacement...
October 19, 2023: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Behnam Sadeghirad, Benjamin T Dodsworth, Nayeli Schmutz Gelsomino, Nicolai Goettel, Jessica Spence, Tayler A Buchan, Holly N Crandon, Mohammad R Baneshi, Robert A Pol, Baukje Brattinga, Ui Jun Park, Masanori Terashima, Louise B D Banning, Barbara L Van Leeuwen, Bjørn E Neerland, Alwin Chuan, Felipe T Martinez, Jeroen L A Van Vugt, Y Raja Rampersaud, Shingo Hatakeyama, Enrico Di Stasio, Koen Milisen, Bastiaan Van Grootven, Lijckle van der Laan, Linda Thomson Mangnall, Sarah J Goodlin, Diana Lungeanu, Kris Denhaerynck, Vibhawari Dhakharia, Elizabeth L Sampson, Michael G Zywiel, Lisa Falco, Anna-Lisa V Nguyen, Stephana J Moss, Karla D Krewulak, Natalia Jaworska, Kara Plotnikoff, Supun Kotteduwa-Jayawarden, Ryan Sandarage, Jason W Busse, Lawrence Mbuagbaw
IMPORTANCE: Postoperative delirium (POD) is a common and serious complication after surgery. Various predisposing factors are associated with POD, but their magnitude and importance using an individual patient data (IPD) meta-analysis have not been assessed. OBJECTIVE: To identify perioperative factors associated with POD and assess their relative prognostic value among adults undergoing noncardiac surgery. DATA SOURCES: MEDLINE, EMBASE, and CINAHL from inception to May 2020...
October 2, 2023: JAMA Network Open
#9
JOURNAL ARTICLE
Yan Long, Xiao-Lu Zhou, Cheng-Long Zhang, Ya-Nan Wang, Wen-Sheng Pan
BACKGROUND: Preoperative anemia is associated with increased postoperative morbidity and mortality and increased perioperative transfusion risk. For surgical patients, this affects physical and cognitive ability and quality of life, but it is an important and modifiable risk factor. AIM: To determine the effect of preoperative anemia on the prognosis of gastric cancer (GC) patients and generate a prognostic nomogram to predict the postoperative overall survival (OS) of GC patients with preoperative anemia...
July 27, 2023: World Journal of Gastrointestinal Surgery
#10
MULTICENTER STUDY
Iain J McCullagh, Barbara Salas, Andrew Teodorczuk, Mark Callaghan
BACKGROUND: Post-operative delirium (POD) is an acute brain failure which may occur following major surgery, with serious implications for participants and caregivers. Evidence regarding optimal anaesthetic management for older participants at higher risk of POD is conflicting. We conducted a feasibility study of our protocol in 5 centres to guide sample size estimation and inform future recruitment strategies for a larger cohort study. METHODS: Participants aged over 65 and scheduled for major surgery were recruited...
July 15, 2023: BMC Geriatrics
#11
JOURNAL ARTICLE
Juwei Zhang, Jinsong Zhou, Yue Huang, Zheng Lin, Suhong Zhang, Minglian Qiu, Zhisheng Xiang, Zhijian Hu
OBJECTIVE: Dietary antioxidants are associated with risk of death in cancer patients, and they were used to evaluate the prognosis of cancer patients. Dietary antioxidant index (DAI) can be used to evaluate dietary antioxidant content comprehensively; this study aimed to investigate the effect of preoperative DAI on health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC). METHODS: Data on dietary intakes were collected using a validated food-frequency questionnaire (FFQ)...
June 21, 2023: Nutrients
#12
JOURNAL ARTICLE
Steen Gregers Hasselbalch, Jonathan Frederik Carlsen, Mohamed Moussa Alaouie, Tina Nørgaard Munch, Anders Vedel Holst, Sarah Taudorf, Christina Rørvig-Løppentien, Marianne Juhler, Gunhild Waldemar
BACKGROUND AND PURPOSE: Idiopathic normal pressure hydrocephalus (iNPH) is a potentially treatable disorder, but prognostic tests or biomarkers are lacking. The aim was to study the predictive power of clinical, neuroimaging and lumbar infusion test parameters (resistance to outflow Rout , cardiac-related pulse amplitude PA and the PA to intracranial pressure ICP ratio). METHODS: In all, 127 patients diagnosed with iNPH who had a lumbar infusion test, a subsequent ventriculo-peritoneal shunt operation and at least 2 months of postoperative follow-up were retrospectively included...
October 2023: European Journal of Neurology
#13
JOURNAL ARTICLE
Anna Dorothea Kuhlmann, Claudia Spies, Erika Schulte, Maximilian Jara, Clarissa von Haefen, Mandy Mertens, Laura Anouk Süß, Nathalie Winkler, Gunnar Lachmann, Cornelia Lachmann
OBJECTIVES: Preoperative hypoalbuminaemia is associated with adverse outcome, including increased postoperative mortality in cardiovascular surgery, neurosurgery, trauma and orthopaedic surgery. However, much less is known about the association between preoperative serum albumin and clinical outcomes after liver surgery. In this study, we sought to determine whether hypoalbuminaemia before partial hepatectomy is associated with a worse postoperative outcome. DESIGN: Observational study...
May 18, 2023: BMJ Open
#14
JOURNAL ARTICLE
Maartje Belt, Bart Robben, José M H Smolders, B W Schreurs, Gerjon Hannink, Katrijn Smulders
To map literature on prognostic factors related to outcomes of revision total knee arthroplasty (rTKA), to identify extensively studied factors and to guide future research into what domains need further exploration. We performed a systematic literature search in MEDLINE, Embase, and Web of Science. The search string included multiple synonyms of the following keywords: "revision TKA", "outcome" and "prognostic factor". We searched for studies assessing the association between at least one prognostic factor and at least one outcome measure after rTKA surgery...
May 10, 2023: Bone & joint open
#15
JOURNAL ARTICLE
Abner Sergooris, Jonas Verbrugghe, Thomas Matheve, Maaike Van Den Houte, Bruno Bonnechère, Kristoff Corten, Katleen Bogaerts, Annick Timmermans
BACKGROUND: Large heterogeneity exists in the clinical manifestation of hip osteoarthritis (OA). It is therefore not surprising that pain and disability in individuals with hip OA and after total hip arthroplasty (THA) cannot be explained by biomedical variables alone. Indeed, also maladaptive pain-related cognitions and emotions can contribute to pain and disability, and can lead to poor treatment outcomes. Traumatic experiences, mental disorders, self-efficacy and social support can influence stress appraisal and strategies to cope with pain, but their influence on pain and disability has not yet been established in individuals with hip OA undergoing THA...
March 25, 2023: BMC Musculoskeletal Disorders
#16
JOURNAL ARTICLE
Sergio Sandrucci
Despite the clear clinical significance of frailty in surgical populations, there is no consensus on how best to define or measure frailty, even within the geriatric literature. A diversity of measures exists to measure some or all these domains, but only research-focused tools have been validated in surgical populations. These tools are too resource-intensive for rapid, cost-effective, preoperative screening of entire populations considering elective surgery. This narrative review deals with the definition of frailty and the different assessment methods of the phenotypic definition and the accumulation of deficits definition...
March 5, 2023: European Journal of Surgical Oncology
#17
JOURNAL ARTICLE
Emma Kofoed Lauridsen, Urszula Maria Ciochon, Anders Tolver, Mark Bech Knudsen, Laura Giraldi, Jacob Bertram Springborg, Lars Bøgeskov, Lars Poulsgaard, Tiit Mathiesen, Karin Piil, Kåre Fugleholm
OBJECTIVE: Subfrontal meningiomas grow insidiously in areas with high cerebral compliance and a relative scarcity of eloquent function. Symptoms develop progressively, are nonspecific, and include anosmia, changes in personality and cognition, depressive symptoms, headaches, visual disturbances, and seizures. Patients with subfrontal meningiomas carry the highest risk of developing psychological symptoms, which makes patient-reported outcome in terms of long-term health-related quality of life (HRQOL), anxiety, and depression of particular importance...
November 11, 2022: Journal of Neurosurgery
#18
JOURNAL ARTICLE
Ann-Kathrin Bruzsa, Katrin Walther, Burkhard S Kasper, Stefanie Gollwitzer, Hajo Hamer, Michael Schwarz
BACKGROUND: Epilepsy surgery offers an effective treatment to achieve seizure freedom in refractory temporal lobe epilepsy. Since left temporal lobe surgery can be associated with verbal memory deterioration, control of cognitive decline is a main goal of therapy. This study analyzes the prognostic value of intracarotid amobarbital procedure (Wada test) in addition to specific neuropsychological and clinical variables for postoperative memory changes. METHOD: Between 2013 and 2021 thirty-six patients (18 females, 18 males, mean age 41...
December 29, 2022: Clinical Neurology and Neurosurgery
#19
JOURNAL ARTICLE
Wenbin Lu, Keqin Zhang, Xinning Chang, Xiya Yu, Jinjun Bian
Purpose: Postoperative cognitive decline (POCD) is highly prevalent in elderly patients who received surgery. The systemic immune-inflammation index (SII) has been shown to be an independent predictor of many diseases associated with inflammation, but the relationship between the SII and POCD is unknown. We aimed to investigate the association between POCD and SII levels to examine the potential of SII in predicting POCD in elderly patients. Patients and Methods: The present study was carried out among elderly patients who underwent elective orthopedics operation in our hospital, and SII, neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) were calculated from the admission blood sample...
2022: Clinical Interventions in Aging
#20
JOURNAL ARTICLE
Hélène Levassort, Stéphanie Benyahia, Marion Pépin, Marinella Guido, Tristan Cudennec
With the ageing of the population and the increase in the incidence of cancer in the population over 75 years of age, a partnership between geriatricians and oncologists is becoming necessary to optimise the management of these patients. There is great variability in the profiles of elderly patients and age cannot be the only criterion of the decision making. Thus, it is necessary to identify patients who will benefit from an in-depth geriatric assessment (IGA) and the G8 screening tool used in oncology consultations allows to do so...
March 2022: Soins. Gérontologie
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