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Cognitive prognostication

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https://www.readbyqxmd.com/read/29344836/boost-irradiation-integrated-to-whole-brain-radiotherapy-in-the-management-of-brain-metastases
#1
Ágnes Dobi, Emese Fodor, Anikó Maráz, Zsófia Együd, Adrienne Cserháti, László Tiszlavicz, Zita Reisz, Pál Barzó, Zoltán Varga, Katalin Hideghéty
Our retrospective analysis aimed to evaluate the clinical value of dose intensification schemes: WBRT and consecutive, delayed, or simultaneous integrated boost (SIB) in brain metastasis (BM) management. Clinical data and overall survival (OS) of 468 patients with BM from various primaries treated with 10 × 3 Gy WBRT (n = 195), WBRT+ 10 × 2 Gy boost (n = 125), or simultaneously 15 × 2.2 Gy WBRT+0.7 Gy boost (n = 148) during a 6-year period were statistically analysed. Significant difference in OS could be detected with additional boost to WBRT (3...
January 17, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29331842/predicting-1-year-disability-and-mortality-of-injured-older-adults
#2
Alvin D Jeffery, Mary S Dietrich, Cathy A Maxwell
PURPOSE: The growing incidence of elderly patients injured from falls, combined with a growing understanding of the contribution of cognition and frailty to mortality, prompted this work. Our objective was to develop a clinical risk prediction model for prognosticating disability and mortality among injured older adults 1 year after hospitalization. METHODS: Secondary analysis of prospective longitudinal data from an urban Level 1 trauma center. A proportional odds regression model was used to model mortality and functional status as ordinal outcomes...
January 6, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29325567/identifying-older-adults-at-risk-of-harm-following-elective-surgery-a-systematic-review-and-meta-analysis
#3
Jennifer Watt, Andrea C Tricco, Catherine Talbot-Hamon, Ba' Pham, Patricia Rios, Agnes Grudniewicz, Camilla Wong, Douglas Sinclair, Sharon E Straus
BACKGROUND: Elective surgeries can be associated with significant harm to older adults. The present study aimed to identify the prognostic factors associated with the development of postoperative complications among older adults undergoing elective surgery. METHODS: Medline, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials, and AgeLine were searched for articles published between inception and April 21, 2016. Prospective studies reporting prognostic factors associated with postoperative complications (composite outcome of medical and surgical complications), functional decline, mortality, post-hospitalization discharge destination, and prolonged hospitalization among older adults undergoing elective surgery were included...
January 12, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29314447/prognostic-value-of-psychosocial-factors-for-first-and-recurrent-hospitalizations-and-mortality-in-heart-failure-patients-insights-from-the-opera-hf-study
#4
Ioanna Sokoreli, Steffen C Pauws, Ewout W Steyerberg, Gert-Jan de Vries, Jarno M Riistama, Aleksandra Tesanovic, Syed Kazmi, Pierpaolo Pellicori, John G Cleland, Andrew L Clark
AIMS: Psychosocial factors are rarely collected in studies investigating the prognosis of patients with heart failure (HF), and only time to first event is commonly reported. We investigated the prognostic value of psychosocial factors for predicting first or recurrent events after discharge following hospitalization for HF. METHODS AND RESULTS: OPERA-HF is an observational study enrolling patients hospitalized for HF. In addition to clinical variables, psychosocial variables are recorded...
January 4, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29310988/an-updated-diagnostic-approach-to-subtype-definition-of-vascular-parkinsonism-recommendations-from-an-expert-working-group
#5
REVIEW
Ivan Rektor, Nicolaas I Bohnen, Amos D Korczyn, Viktoria Gryb, Hrishikesh Kumar, Milica G Kramberger, Frank-Erik de Leeuw, Zvezdan Pirtošek, Irena Rektorová, Ilana Schlesinger, Jaroslaw Slawek, Peter Valkovič, Branislav Veselý
This expert working group report proposes an updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic approach intends to provide a comprehensive tool for clinical practice. The preamble for this initiative is that VaP can be diagnosed in individual patients with possible prognostic and therapeutic consequences and therefore should be recognized as a clinical entity...
December 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29306668/a-prognostic-model-of-alzheimer-s-disease-relying-on-multiple-longitudinal-measures-and-time-to-event-data
#6
Kan Li, Richard O'Brien, Michael Lutz, Sheng Luo
INTRODUCTION: Characterizing progression in Alzheimer's disease is critically important for early detection and targeted treatment. The objective was to develop a prognostic model, based on multivariate longitudinal markers, for predicting progression-free survival in patients with mild cognitive impairment. METHODS: The information contained in multiple longitudinal markers was extracted using multivariate functional principal components analysis and used as predictors in the Cox regression models...
January 3, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29306185/pre-stroke-employment-results-in-better-patient-reported-outcomes-after-minor-stroke-short-title-functional-outcomes-after-minor-stroke
#7
Elisabeth B Marsh, Erin Lawrence, Argye E Hillis, Karen Chen, Rebecca F Gottesman, Rafael H Llinas
OBJECTIVE: Individuals with "minor stroke" lack a dense hemiparesis or aphasia; however, commonly endorse persistent cognitive and motor problems despite low NIHSS scores. They also report problems with mood, energy, and the ability to think clearly that are less well characterized. Socioeconomic factors and stroke severity can influence patient-reported outcomes. In this study we explore patient-reported outcomes and the influence of these factors after minor stroke. PATIENTS AND METHODS: Patients returning to clinic post-stroke with an NIHSS of ≤ 4 were administered a scale to quantify problems with daily activities and resulting functional burden, along with measures of fatigue and depression...
December 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29296099/can-information-on-functional-and-cognitive-status-improve-short-term-mortality-risk-prediction-among-community-dwelling-older-people-a-cohort-study-using-a-uk-primary-care-database
#8
Janet Sultana, Andrea Fontana, Francesco Giorgianni, Giorgio Basile, Elisabetta Patorno, Alberto Pilotto, Mariam Molokhia, Robert Stewart, Miriam Sturkenboom, Gianluca Trifirò
Background: Functional and cognitive domains have rarely been evaluated for their prognostic value in general practice databases. The aim of this study was to identify functional and cognitive domains in The Health Improvement Network (THIN) and to evaluate their additional value for the prediction of 1-month and 1-year mortality in elderly people. Materials and methods: A cohort study was conducted using a UK nationwide general practitioner database. A total of 1,193,268 patients aged 65 years or older, of whom 15,300 had dementia, were identified from 2000 to 2012...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29291599/a-2-year-prospective-follow-up-study-of-temporal-changes-associated-with-post-stroke-cognitive-impairment
#9
HyunSoo Oh, JongSuk Park, WhaSook Seo
AIMS: To explore temporal patterns of change in cognitive impairments during the 2 years following stroke and to identify factors that affect these temporal changes. BACKGROUND: Despite the prognostic importance, temporal changes in post-stroke cognitive impairment have not been systematically investigated. DESIGN: A non-experimental, prospective, longitudinal descriptive study design. METHODS: Fifty-two stroke patients were enrolled...
January 1, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29289386/mortality-risk-factors-in-elderly-patients-in-intensive-care-without-limitation-of-therapeutic-effort
#10
S E Giannasi, M S Venuti, A D Midley, N Roux, C Kecskes, E San Román
OUTCOME: To determine mortality prognostic factors in elderly patients who are admitted to intensive care units (ICUs) due to acute critical illness. DESIGN: A prospective cohort study was carried out. SETTING: A polyvalent Intensive Care Unit at a University Hospital in Argentina. PATIENTS OR PARTICIPANTS: We included 249 patients over 65years of age who were consecutively admitted to the ICU and required mechanical ventilation for more than 48hours, between January 2011 and December 2012...
December 27, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29278887/the-diagnostic-and-prognostic-value-of-a-dual-tasking-paradigm-in-a-memory-clinic
#11
Malene Schjnning Nielsen, Anja Hviid Simonsen, Volkert Siersma, Steen Gregers Hasselbalch, Peter Hoegh
BACKGROUND: Daily living requires the ability to perform dual-tasking. As cognitive skills decrease in dementia, performing a cognitive and motor task simultaneously become increasingly challenging and subtle gait abnormalities may even be present in pre-dementia stages. Therefore, a dual-tasking paradigm, such as the Timed Up and Go-Dual Task (TUG-DT), may be useful in the diagnostic assessment of mild cognitive impairment (MCI). OBJECTIVE: To investigate the diagnostic and prognostic ability of a dual-tasking paradigm in patients with MCI or mild Alzheimer's disease (AD) and to evaluate the association between the dual-tasking paradigm and cerebrospinal fluid (CSF) AD biomarkers...
December 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29278641/reduction-of-brain-volumes-after-neonatal-cardiopulmonary-bypass-surgery-in-single-ventricle-congenital-heart-disease-prior-to-fontan-completion
#12
Kristina N Mayer, Walter Knirsch, Beatrice Latal, Ianina Scheer, Kristina Wetterling, Andreas Hahn, Hakan Akintürk, Dietmar Schranz, Ingrid Beck, Ruth ÓGorman Tuura, Bettina Reich
BACKGROUND: Little is known about the relationship between brain volumes and neurodevelopmental outcome at two years of age in children with single ventricle congenital heart disease (CHD). We hypothesized that reduced brain volumes may be associated with adverse neurodevelopmental outcome. METHODS: Volumetric segmentation of cerebral MRI scans was done in 44 patients without genetic comorbidities and in eight controls. Neurodevelopmental outcome was assessed with the Bayley-III scales...
August 21, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29278290/identification-of-prognostic-factors-for-activities-of-daily-living-in-elderly-patients-after-hospitalization-for-acute-infectious-disease-in-japan-a-6-month-follow-up-study
#13
Ryohei Goto, Hiroki Watanabe, Junji Haruta, Madoka Tsutsumi, Shoji Yokoya, Tetsuhiro Maeno
AIM: We investigated factors that predict the prognosis of activities of daily living (ADL) in elderly patients who had undergone rehabilitation during hospitalization for acute infectious disease. METHODS: The present prospective cohort study included 131 patients who were hospitalized due to acute infectious disease and who had undergone rehabilitation during hospitalization. Patient characteristics collected from medical records included age, sex and comorbidity score...
December 26, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29278101/bayesian-hidden-markov-models-for-delineating-the-pathology-of-alzheimer-s-disease
#14
Kai Kang, Jingheng Cai, Xinyuan Song, Hongtu Zhu
Alzheimer's disease is a firmly incurable and progressive disease. The pathology of Alzheimer's disease usually evolves from cognitive normal, to mild cognitive impairment, to Alzheimer's disease. The aim of this paper is to develop a Bayesian hidden Markov model to characterize disease pathology, identify hidden states corresponding to the diagnosed stages of cognitive decline, and examine the dynamic changes of potential risk factors associated with the cognitive normal-mild cognitive impairment-Alzheimer's disease transition...
January 1, 2017: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29262435/neuroprognostication-of-cardiac-arrest-patients-outcomes-of-importance
#15
Tobias Cronberg
During the last two decades, survival rates after cardiac arrest have increased while the fraction of patients surviving with a severe neurological disability or vegetative state has decreased in many countries. While improved survival is due to improvements in the whole "chain of survival," improved methods for prognostication of neurological outcome may be of major importance for the lower disability rates. Patients who are resuscitated and treated in intensive care will die mainly from the withdrawal of life-sustaining (WLST) therapy due to presumed poor chances of meaningful neurological recovery...
December 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29237697/triple-a-syndrome-a-wide-spectrum-of-adrenal-dysfunction
#16
Florence Roucher-Boulez, Aude Brac de la Perrière, Aude Jacquez, Delphine Chau, Laurence Guignat, Christophe Vial, Yves Morel, Marc Nicolino, Gerald Raverot, Michel Pugeat
Objective: Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: Alacrima, Achalasia and Adrenal Insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. Methods: A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center...
December 13, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29233607/the-concept-of-frailty-in-intensive-care
#17
Fakhri Athari, Ken M Hillman, Steven A Frost
Our population is ageing and this is also reflected in the ageing of the hospital and intensive care population. Along with ageing, there is also an increase in age-related chronic health conditions or co-morbidities, which in turn affects the patient's functional state. There is an increasing need to describe a patient's clinical condition in terms of their functional capacity, such as frailty. Frailty is an age-related syndrome which reduces physiological and cognitive reserves. As a result, frailty increases people's vulnerability to insults such as infection and trauma...
December 9, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29233469/olfactory-dysfunctions-in-drug-na%C3%A3-ve-parkinson-s-disease-with-mild-cognitive-impairment
#18
Jin-Woo Park, Do-Young Kwon, Ji Ho Choi, Moon-Ho Park, Ho-Kyoung Yoon
BACKGROUND: Evaluation of olfactory function is valuable for the detection of pre-motor state of Parkinson's disease (PD). PD patients have an increased risk of associated dementia and one-third of PD patients have mild cognitive impairment (MCI) at the time of diagnosis. However, the characteristics of olfactory dysfunction in PD-MCI patients are unclear. This study examined the relationship between olfactory dysfunction and cognitive function in drug-naïve PD at the time of diagnosis with the patterns of olfactory function in PD-MCI patients using the Korean version of the Sniffin' stick test II (KVSS II)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29224694/chronic-musculoskeletal-pain-and-its-impact-on-older-people
#19
REVIEW
Fiona M Blyth, Naomi Noguchi
Musculoskeletal conditions are the leading cause of disability worldwide and also have a large impact on many other aspects of older people's health such as low physical activity level, poor mobility, frailty, depression, cognitive impairment, falls and poor sleep quality. Clustering of musculoskeletal pain with other pain conditions is also common, and the number of pain sites is an important prognostic factor. While musculoskeletal pain is usually nociceptive in origin, older people with musculoskeletal conditions may also experience neuropathic pain and central pain syndromes...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29223603/factors-predicting-quality-of-life-and-societal-participation-after-survival-of-a-cardiac-arrest-a-prognostic-longitudinal-cohort-study
#20
Daan Verberne, Veronique Moulaert, Jeanine Verbunt, Caroline van Heugten
AIM: For those patients who suffer unfavourable outcome after survival of cardiac arrest, it is important to know whether this can be predicted at an early stage. Support can subsequently be provided. This study aimed to identify early prognostic factors of quality of life (QOL) and societal participation at one year post-cardiac arrest. METHODS: The design was a prospective longitudinal cohort study following cardiac arrest survivors up to one year. Prognostic personal, injury-related, function-related and subjective outcome factors were selected and entered into a hierarchical regression model to assess whether they were predictive of QOL and societal participation at one year post-cardiac arrest...
December 6, 2017: Resuscitation
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