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https://www.readbyqxmd.com/read/28781816/bevacizumab-plus-chemotherapy-continued-beyond-progression-in-patients-with-type-ii-endometrial-cancer-previously-treated-with-bevacizumab-plus-chemotherapy-a-case-report
#1
Emi Sato, Kentaro Nakayama, Kohei Nakamura, Tomoka Ishibashi, Hiroshi Katagiri, Masako Ishikawa, Satoru Kyo
The prognosis of patients with recurrent/persistent endometrial cancer, particularly type II cancer, remains poor, and effective treatment has not yet been established. We herein present the case of a patient with recurrent type II endometrial cancer who received bevacizumab + chemotherapy continued beyond progression, after previously receiving bevacizumab + chemotherapy. This patient experienced recurrence after first- and second-line adjuvant chemotherapy followed by modified radical hysterectomy and she was administered bevacizumab + paclitaxel + carboplatin therapy...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28751235/laparoscopic-uterovaginal-anastomosis-for-cervical-agenesis-a-case-report
#2
Ameya Padmawar, Rizwana Syed, Suyash Naval
STUDY OBJECTIVE: To demonstrate possibility of an innovative surgery for management of cervical agenesis. DESIGN: Step wise description of laparoscopic uterovaginal anastomosis. SETTING: Isolated cervical agenesis occurs in 1 in 80000 to 100000 births. According to the American Fertility Society, cervical agenesis should be classified as a type Ib müllerian anomaly. According to ESHRE/ESGE classification, it is classified in class C4 category...
July 24, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28747229/vaginal-metastasis-as-the-initial-presentation-of-leiomyosarcoma-a-case-report
#3
Cecilia Villalaín-González, Álvaro Tejerizo-García, Patricia Lopez-Garcia, Gregorio López-González, Ma Reyes Oliver-Perez, Jesús S Jiménez-López
BACKGROUND: Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on optimal management strategies. CASE PRESENTATION: A 60-year-old woman with a history of an asymptomatic uterine leiomyoma presented in October 2015 with postmenopausal bleeding and a friable vaginal cyst that bled when palpated. A partial cystectomy was performed, and malignant-like cystic and solid components were identified...
July 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28712200/pregnancy-with-bilateral-metastatic-ovarian-tumour
#4
Sadaqat Jabeen, Maleeha Nisar, Nighat Hussain
Metastatic ovarian tumours are extremely rare. The commonest primary site is usually stomach and the metastasis from this site is termed as krukenberg tumour. It accounts for 1-2% of malignant ovarian tumours. We present a case of 14 weeks' pregnancy with metastatic bilateral malignant ovarian tumour is presented. Diagnosis was made on ultrasound. Tumour markers were insignificant. Patient underwent staging laparotomy with total abdominal hysterectomy and bilateral salpingo oophorectomy and partial omentectomy...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28662703/the-diagnosis-of-a-metastatic-breast-tumor-from-ovarian-cancer-by-the-succession-of-a-p53-mutation-a-case-report
#5
Ryutaro Mori, Manabu Futamura, Kasumi Morimitsu, Chiemi Saigo, Tatsuhiko Miyazaki, Kazuhiro Yoshida
BACKGROUND: Metastatic breast tumors from other organs are very rare. We herein describe the case of a patient with a metastatic breast tumor due to ovarian cancer who was diagnosed by the succession of a p53 mutation. CASE PRESENTATION: The patient was a 59-year-old woman with sigmoid colon stenosis. Diagnostic imaging revealed a pelvic mass, multiple liver tumors, ascites, and multiple swollen para-aortic lymph nodes, suggesting an advanced ovarian tumor. Transverse loop colostomy and partial resection of the greater omentum was performed followed by six cycles of paclitaxel with carboplatin chemotherapy (TC therapy)...
June 29, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28656271/role-of-transforming-growth-factor-%C3%AE-%C3%A2-1-in-the-pathogenesis-of-pelvic-organ-prolapse-a-potential-therapeutic-target
#6
Cheng Liu, Ying Wang, Bing-Shu Li, Qing Yang, Jian-Ming Tang, Jie Min, Sha-Sha Hong, Wen-Jun Guo, Li Hong
The present study aimed to reveal the metabolic alterations of the extracellular matrix (ECM) in uterosacral ligament (USL) with pelvic organ prolapse (POP) and to explore the role of transforming growth factor‑β1 (TGF‑β1) in pathogenesis of POP. For this purpse, 60 participants who underwent hysterectomy for benign indications were enrolled, 30 of which had symptomatic POP (grade II, III or IV) and composed the POP group, and the other 30 had asymptomatic POP (grade I or less) and served as the controls...
June 26, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28625456/the-effect-of-ondansetron-on-analgesic-efficacy-of-acetaminophen-after-hysterectomy-a-randomized-double-blinded-placebo-controlled-trial
#7
Onur Koyuncu, Steve Leung, Jing You, Menekse Oksar, Selim Turhanoglu, Cagla Akkurt, Kenan Dolapcioglu, Hanifi Sahin, Daniel I Sessler, Alparslan Turan
OBJECTIVES: To determine that perioperative ondansetron reduces the analgesic efficacy of acetaminophen. DESIGN: Randomized, double-blinded study. PATIENTS: 120 patients ASA I-II who underwent abdominal hysterectomy. INTERVENTIONS: All the patients were given 1g acetaminophen at skin closure. Patients were divided into two groups; ondansetron HCl (8mg, 2ml IV) (Group I, N=60) and saline (2ml IV) (Group II, N=60) at the skin closure...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28600055/recurrent-female-adnexal-tumor-of-probably-wolffian-origin-a-case-report
#8
Tian Qiu, Yincheng Teng, Jianqian Tong, Wenqi Tao, Liang Xu
OBJECTIVE: Wolffian adnexal tumors (WATs) are rare, and metastasis is uncommon. We present the case of a 53-year-old female with a recurrent WAT. CASE REPORT: The patient presented with abdominal distension, and ultrasound revealed heterogeneous echoes (130 × 93 × 116 mm(3)) around the uterus and ascites. Her cancer antigen 125 (CA125) and CA19-9 levels were elevated. Hysterectomy, bilateral oophorectomy, and tumor resection were performed. The histopathological diagnosis was a WAT...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28600047/maternal-outcome-after-conservative-management-of-abnormally-invasive-placenta
#9
Hsiu-Wei Su, Yu-Chiao Yi, Jenn-Jhy Tseng, Wei-Chih Chen, Ya-Fang Chen, Hsiao-Fan Kung, Min-Min Chou
OBJECTIVE: The purpose of this study was to describe our preliminary experience of the efficacy and safety of a conservative strategy for abnormally invasive placenta. MATERIALS AND METHODS: A retrospective review of eight pregnant women with abnormally invasive placenta (one with placenta previa accrete, three with placenta previa increta, and four with previa percreta) was performed. The diagnosis was made by prenatal ultrasonography, and was confirmed by operative and histopathological findings...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28427775/nonoperative-management-of-atypical-endometrial-hyperplasia-and-grade-1-endometrial-cancer-with-the-levonorgestrel-intrauterine-device-in-medically-ill-post-menopausal-women
#10
William D Baker, Stuart R Pierce, Anne M Mills, Paola A Gehrig, Linda R Duska
OBJECTIVE: To assess the endometrial response rates to treatment with the levonorgestrel intrauterine device in post-menopausal women with atypical hyperplasia/endometrial intraepithelial neoplasia and grade 1 endometrioid (AH/EC) endometrial carcinoma who are not surgical candidates. METHODS: Chart review was undertaken of patients with AH/EC who underwent levonorgestrel intrauterine device insertion by a gynecologic oncologist within two academic health systems between 2002 and 2013...
July 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28424084/durable-complete-remission-with-aromatase-inhibitor-therapy-in-a-patient-with-metastatic-uterine-carcinosarcoma-with-poor-performance-status-and-coagulation-disorders-a-case-report
#11
P Martin-Romano, M Jurado, M A Idoate, L Arbea, J L Hernandez-Lizoain, D Cano, J A Paramo, S Martin-Algarra
BACKGROUND: Chemotherapy is considered the most appropriate treatment for metastatic uterine sarcoma, despite its limited efficacy. No other treatment has been conclusively proved to be a real alternative, but some reports suggest that anti-hormonal therapy could be active in a small subset of patients. We report the case of a patient with metastatic uterine carcinosarcoma with positive hormonal receptors and a complete pathological response. CASE PRESENTATION: A 54-year-old white woman presented to our emergency room with hypovolemic shock and serious vaginal bleeding...
April 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28390819/ywhae-rearranged-high-grade-endometrial-stromal-sarcoma-two-center-case-series-and-response-to-chemotherapy
#12
MULTICENTER STUDY
Matthew L Hemming, Andrew J Wagner, Marisa R Nucci, Sarah Chiang, Lu Wang, Martee L Hensley, Suzanne George
OBJECTIVES: YWHAE-rearranged high-grade endometrial stromal sarcoma (HG-ESS) is a rare, recently defined uterine sarcoma harboring t(10;17)(q22;p13) resulting in YWHAE-NUTM2A/B fusion. Chemotherapy sensitivity of metastatic YWHAE-rearranged HG-ESS is unknown. We reviewed the response to chemotherapy in women with YWHAE-rearranged HG-ESS to provide guidance for clinical management. METHODS: We retrospectively identified patients diagnosed with YWHAE-rearranged HG-ESS who received treatment for metastatic disease at our institutions...
June 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28384936/transvaginal-sonography-versus-cystoscopy-for-detecting-urinary-bladder-invasion-in-early-stage-cervical-cancer
#13
Vijay Zutshi, Binni Makkar, Anju Garg, Swaraj Batra
INTRODUCTION: Cervical cancer is a major cause of mortality from cancer among women. In it's early stage pre operative staging with cystoscopy is a standard procedure for the detection of urinary bladder involvement. AIM: The present study was conducted with the aim to compare the efficacy of Transvaginal Sonography (TVS) and cystoscopy in diagnosing bladder involvement in early stage cervical cancer patients by confirming it intraoperatively and further by histopathologic examination...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28377901/unusual-presentation-of-invasive-mole-a-case-report
#14
Soheila Aminimoghaddam, Andisheh Maghsoudnia
BACKGROUND: Invasive mole is responsible for most cases of localized gestational trophoblastic neoplasia. Gestational trophoblastic disease describes a number of gynecologic tumors that originate in trophoblastic layer including hydatidiform mole (complete or partial), invasive mole, choriocarcinoma, placental site trophoblastic tumor and epitheloid trophoblastic tumor. Invasive mole may arise from any pregnancy event although in most cases is diagnosed after molar pregnancy. Overall cure rate in low risk patients is nearly 100% and in high-risk patient 90%...
January 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/28365166/-i-was-close-to-death-abortion-and-medical-risk-on-american-television-2005-2016
#15
Gretchen Sisson, Brenly Rowland
OBJECTIVES: To examine the portrayal of complications and long-term health consequences associated with abortion on television, recognizing the impact that fictional stories can have on public beliefs about abortion's safety. STUDY DESIGN: Using a systematic online search, we identified all instances of abortion on US television from 2005 to 2016. We qualitatively coded these plotlines to identify any occurrences of complications, interventions or long-term health consequences associated with abortion care, with 95% intercoder reliability...
July 2017: Contraception
https://www.readbyqxmd.com/read/28314289/dose-dense-paclitaxel-and-carboplatin-based-neoadjuvant-chemotherapy-followed-by-surgery-or-concurrent-chemo-radiotherapy-in-cervical-cancer-a-preliminary-analysis
#16
Angiolo Gadducci, Cecilia Barsotti, Concetta Laliscia, Stefania Cosio, Antonio Fanucchi, Roberta Tana, Maria Grazia Fabrini
AIM: To assess preliminary results with dose-dense neoadjuvant chemotherapy (NACT) prior to surgery or concurrent chemo-radiotherapy (CCRT) in cervical cancer. PATIENTS AND METHODS: Thirty patients received weekly paclitaxel (80 mg/m(2)) plus carboplatin (AUC2) for 6 cycles followed by radical hysterectomy in 16 (stage Ib2-IIb), conisation in one (stage Ib1), and CCRT in 13 (stage Ib2-IIb). Median follow-up of survivors was 12 months (range=3-22). RESULTS: Among the surgically treated patients, clinical overall response rate (RR) was 82...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28272244/management-of-patients-with-placenta-accreta-in-association-with-fever-following-vaginal-delivery
#17
Liuying Zhong, Dunjin Chen, Mei Zhong, Yutian He, Chunhong Su
This study aims to analyze the clinical characteristics and to manage patients with retained placenta left in situ accompanied by fever following vaginal delivery.Twenty-one patients with retained placenta in association with fever following vaginal delivery were enrolled and managed at the maternity department of our university hospital between 2012 and 2014.All patients had risk factors for development of placenta accreta: previous cesarean sections (4/21), previous curettage (15/21), or uterine malformations (7/21)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28250728/case-report-of-ovarian-torsion-mimicking-ovarian-cancer-as-an-uncommon-late-complication-of-laparoscopic-supracervical-hysterectomy
#18
Michał Ciebiera, Arkadiusz Baran, Aneta Słabuszewska-Jóźwiak, Grzegorz Jakiel
Laparoscopic supracervical hysterectomy (LSH) is an example of a partial hysterectomy, performed due to benign gynaecological complaints. Better endoscopic instruments and operational techniques have led to a great reduction in the number of abdominal hysterectomies. It is believed that LSH is a safe and minimally invasive hysterectomy technique. The Cochrane Database meta-analysis proves the benefits of minimally invasive surgery compared with abdominal gynaecological surgery, including decreased pain, surgical-site infections and hospital stay, quicker return to activity, and fewer postoperative adhesions...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28228433/case-of-primary-bilateral-diffuse-large-b-cell-lymphoma-of-the-ovary-with-plasmablastic-features-in-an-hiv-negative-female-patient
#19
Suvarna L Guvvala, Sailaja Sakam, Masooma Niazi, Yevgeniy Skaradinskiy
A 37-year-old woman from Puerto Rico presented to our clinic with symptoms of an abdominal distension progressively worsening over 1 year. A CT of an abdomen and pelvis with contrast was performed and revealed bilateral large heterogeneous pelvic adnexal masses with large ascites and right pleural effusion. Tumour markers CA 125 was 766 U/mL and lactate dehydrogenase was 654 U/L. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy with pelvic lymph node dissection and partial omentectomy...
February 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28187089/clinical-outcome-of-neoadjuvant-radiochemotherapy-in-locally-advanced-cervical-cancer-results-of-an-open-prospective-multicenter-phase-2-study-of-the-north-eastern-german-society-of-gynecological-oncology
#20
Dominique Koensgen, Jalid Sehouli, Antje Belau, Martin Weiss, Matthias B Stope, Vivien Grokopf, Michael Eichbaum, Peter Ledwon, Werner Lichtenegger, Marek Zygmunt, Günter Köhler, Alexander Mustea
OBJECTIVE: The aim of this study was to determine the response rate, toxicity, operability, and surgical complication rate of neoadjuvant concomitant radiochemotherapy (cRCH) (ifosfamide + carboplatin) followed by radical hysterectomy plus external-beam radiotherapy with curative intention in locally advanced primary inoperable stages IIB and IIIB squamous cell cervical cancer. METHODS: Patients with cervical cancer from 8 departments were enrolled. Patients received 3 cycles of ifosfamide 1...
March 2017: International Journal of Gynecological Cancer
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