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https://www.readbyqxmd.com/read/28440488/dipeptidyl-peptidase%C3%A2-4-inhibitor-sitagliptin-prevents-high-glucose%C3%A2-induced-apoptosis-via-activation-of-amp%C3%A2-activated-protein-kinase-in-endothelial-cells
#1
Chao Wu, Shunying Hu, Nanping Wang, Jianwei Tian
Diabetes mellitus (DM), which is a chronic metabolic disorder, is the primary risk factor of life‑threatening vascular complications. Endothelial apoptosis is important in the development of the initial vascular lesion preceding the diabetic disease. Sitagliptin is a dipeptidyl peptidase‑4 (DPP‑4) inhibitor and extensively used in the clinical treatment of DM. DPP‑4 inhibitors have been demonstrated to be beneficial in the improvement of endothelial homeostasis, however the molecular mechanism by which they exhibit these effects remains to be elucidated...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28427557/oxidative-stress-love-and-hate-history-in-central-nervous-system
#2
Genaro Gabriel Ortiz, Fermín P Pacheco Moisés, Mario Mireles-Ramírez, Luis J Flores-Alvarado, Héctor González-Usigli, Víctor J Sánchez-González, Angélica L Sánchez-López, Lorenzo Sánchez-Romero, Eduardo I Díaz-Barba, J Francisco Santoscoy-Gutiérrez, Paloma Rivero-Moragrega
Molecular oxygen is essential for aerobic organisms in order to synthesize large amounts of energy during the process of oxidative phosphorylation and it is harnessed in the form of adenosine triphosphate, the chemical energy of the cell. Oxygen is toxic for anaerobic organisms but it is also less obvious that oxygen is poisonous to aerobic organisms at higher concentrations of oxygen. For instance, oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen at increased partial pressures...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28420694/caffeine-preferentially-protects-against-oxygen-induced-retinopathy
#3
Shuya Zhang, Rong Zhou, Bo Li, Haiyan Li, Yanyan Wang, Xuejiao Gu, Lingyun Tang, Cun Wang, Dingjuan Zhong, Yuanyuan Ge, Yuqing Huo, Jing Lin, Xiao-Ling Liu, Jiang-Fan Chen
Retinopathy of prematurity (ROP) is the leading cause of childhood blindness, but current anti-VEGF therapy is concerned with delayed retinal vasculature, eye, and brain development of preterm infants. The clinical observation of reduced ROP severity in premature infants after caffeine treatment for apnea suggests that caffeine may protect against ROP. Here, we demonstrate that caffeine did not interfere with normal retinal vascularization development but selectively protected against oxygen-induced retinopathy (OIR) in mice...
April 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28420647/incremental-value-of-transthoracic-doppler-echocardiography-assessed-coronary-flow-reserve-in-patients-with-suspected-myocardial-ischemia-undergoing-myocardial-perfusion-scintigraphy
#4
Li-Ming Gan, Sara Svedlund, Ann Wittfeldt, Charlotte Eklund, Sinsia Gao, Göran Matejka, Anders Jeppsson, Per Albertsson, Elmir Omerovic, Amir Lerman
BACKGROUND: Adenosine-assisted transthoracic Doppler-derived coronary flow reserve (TDE-CFR) reflects coronary vascular function. The prognostic and incremental value of left anterior descending coronary artery TDE-CFR above myocardial perfusion scintigraphy in patients with suspected myocardial ischemia has not yet been studied. METHODS AND RESULTS: Three hundred seventy-one patients (mean age, 62.3±8.7 years; 46.8% males) referred to myocardial perfusion scintigraphy attributed to suspected myocardial ischemia were included in the study...
April 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28410617/treatment-with-high-dose-n-3-pufas-has-no-effect-on-platelet-function-coagulation-metabolic-status-or-inflammation-in-patients-with-atherosclerosis-and-type-2-diabetes
#5
Malgorzata Poreba, Magdalena Mostowik, Aleksander Siniarski, Renata Golebiowska-Wiatrak, Krzysztof Piotr Malinowski, Maciej Haberka, Ewa Konduracka, Jadwiga Nessler, Anetta Undas, Grzegorz Gajos
BACKGROUND: Despite numerous studies on cardioprotective effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), there is limited evidence for n-3 PUFA-mediated effects, especially at its higher dose, on cardiovascular risk in patients with type 2 diabetes (DM2) and established atherosclerosis. PURPOSE: To investigate the effect of daily treatment with a higher dose (2 g) of n-3 PUFAs on platelet function, coagulation parameters, fibrin clot properties, markers of systemic inflammation and metabolic status, in patients with atherosclerotic vascular disease and DM2 who receive optimal medical therapy...
April 14, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28396834/toxic-effects-of-dimethyl-sulfoxide-on-red-blood-cells-platelets-and-vascular-endothelial-cells-in-vitro
#6
Xiaoyang Yi, Minxia Liu, Qun Luo, Hailong Zhuo, Hui Cao, Jiexi Wang, Ying Han
Dimethyl sulfoxide (DMSO) is widely used in biological studies as a cryoprotective agent for cells and tissues, and also for cryopreserved platelets (PLTs). However, few data on the toxic effects of DMSO following intravenous infusion of cryopreserved PLTs are available. The aim of this study was to explore dose-related effects of DMSO on red blood cells (RBCs), PLTs and vascular endothelial cells in vitro. The results showed that DMSO treatments had significant effects on RBCs, affecting osmotic fragility and increasing hemolysis...
April 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/28389406/simultaneous-overexpression-of-human-e5nt-and-entpd1-protects-porcine-endothelial-cells-against-h2o2-induced-oxidative-stress-and-cytotoxicity-in-vitro
#7
Elisa Chisci, Marco De Giorgi, Elisa Zanfrini, Angela Testasecca, Elena Brambilla, Alessandro Cinti, Laura Farina, Barbara Kutryb-Zajac, Cristina Bugarin, Chiara Villa, Emanuela Grassilli, Romina Combi, Giuseppe Gaipa, Maria Grazia Cerrito, Ilaria Rivolta, Ryszard Tomasz Smolenski, Marialuisa Lavitrano, Roberto Giovannoni
Ischemia-reperfusion injury (IRI) and oxidative stress still limit the survival of cells and organs in xenotransplantation models. Ectonucleotidases play an important role in inflammation and IRI in transplantation settings. We tested the potential protective effects derived by the co-expression of the two main vascular ectonucleotidases, ecto-5'-nucleotidase (E5NT) and ecto nucleoside triphosphate diphosphohydrolase 1 (ENTPD1), in an in vitro model of H2O2-induced oxidative stress and cytotoxicity. We produced a dicistronic plasmid (named pCX-DI-2A) for the co-expression of human E5NT and ENTPD1 by using the F2A technology...
April 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28386096/a-facile-method-to-probe-the-vascular-permeability-of-nanoparticles-in-nanomedicine-applications
#8
Yan Teck Ho, Giulia Adriani, Sebastian Beyer, Phan-Thien Nhan, Roger D Kamm, James Chen Yong Kah
The effectiveness of nanoparticles (NP) in nanomedicine depends on their ability to extravasate from vasculature towards the target tissue. This is determined by their permeability across the endothelial barrier. Unfortunately, a quantitative study of the diffusion permeability coefficients (Pd) of NPs is difficult with in vivo models. Here, we utilize a relevant model of vascular-tissue interface with tunable endothelial permeability in vitro based on microfluidics. Human umbilical vein endothelial cells (HUVECs) grown in microfluidic devices were treated with Angiopoietin 1 and cyclic adenosine monophosphate (cAMP) to vary the Pd of the HUVECs monolayer towards fluorescent polystyrene NPs (pNPs) of different sizes, which was determined from image analysis of their fluorescence intensity when diffusing across the monolayer...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28383515/abc-transport-proteins-in-cardiovascular-disease-a-brief-summary
#9
REVIEW
Toni Schumacher, Ralf A Benndorf
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in cholesterol homeostasis, blood pressure regulation, endothelial function, vascular inflammation, as well as platelet production and aggregation. In this regard, ABC transporters, such as ABCA1, ABCG5 and ABCG8, were initially found to be responsible for genetically-inherited syndromes like Tangier diseases and sitosterolemia. These findings led to the understanding of those transporter's function in cellular cholesterol efflux and thereby also linked them to atherosclerosis and cardiovascular diseases (CVD)...
April 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28373136/decreased-vasorelaxation-induced-by-iloprost-during-acute-inflammation-in-human-internal-mammary-artery
#10
Nabil Foudi, Gulsev Ozen, Yasmine Amgoud, Liliane Louedec, Christine Choqueux, Aouatef Badi, Larissa Kotelevets, Eric Chastre, Dan Longrois, Xavier Norel
Cyclooxygenase-2 (COX-2) induction in human internal mammary arteries (IMA) under inflammatory conditions has been associated with attenuated norepinephrine (NE)-induced vasoconstriction. This effect was associated with increased prostaglandin (PG) E2 and prostacyclin (PGI2) releases. The present study was designed to assess the role of these PG and their receptors (EP and IP, respectively) on the vascular reactivity during acute inflammation. Isolated IMA were cultured in the absence (Control conditions) or presence (Inflammatory conditions) of both interleukin-1 beta (IL-1β) and lipopolysaccharide (LPS)...
June 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28362840/aspirin-triggered-resolvin-d1-attenuates-pdgf-induced-vascular-smooth-muscle-cell-migration-via-the-cyclic-adenosine-monophosphate-protein-kinase-a-camp-pka-pathway
#11
Giorgio Mottola, Anuran Chatterjee, Bian Wu, Mian Chen, Michael S Conte
BACKGROUND AND OBJECTIVES: Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator that has been previously shown to attenuate vascular smooth muscle cell (VSMC) migration, a key process in the development of intimal hyperplasia. We sought to investigate the role of the cAMP/PKA pathway in mediating the effects of the aspirin-triggered epimer 17R-RvD1 (AT-RvD1) on VSMC migration. METHODS: VSMCs were harvested from human saphenous veins. VSMCs were analyzed for intracellular cAMP levels and PKA activity after exposure to AT-RvD1...
2017: PloS One
https://www.readbyqxmd.com/read/28359053/platelets-as-a-novel-source-of-pro-inflammatory-chemokine-cxcl14
#12
Alexander Witte, Madhumita Chatterjee, Florian Lang, Meinrad Gawaz
OBJECTIVE: Platelets are a major source of chemokines. Here, we demonstrate for the first time that platelets express significant amounts of CXCL14 and disclose powerful effects of platelet-derived CXCL14 on monocyte and endothelial migration. METHODS: The expression of CXCL14 in platelets and in the supernatant of activated platelets was analysed by immunoblotting, ELISA, and flow cytometry. The effect of platelet-derived CXCL14 on monocyte migration was evaluated using a modified Boyden chamber...
March 29, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28346055/a-to-i-editing-in-disease-is-not-fake-news
#13
Prajakta Bajad, Michael F Jantsch, Liam Keegan, Mary O'Connell
Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited with up to one hundred percent efficiency, leading to the production of alternative protein variants. However, the majority of editing events occur within longer stretches of dsRNA formed by pairing of repetitive sequences. Here, many different adenosine bases are potential targets but editing efficiency is usually much lower...
March 27, 2017: RNA Biology
https://www.readbyqxmd.com/read/28343356/development-of-a-novel-strategy-to-target-cd39-antithrombotic-activity-to-the-endothelial-platelet-microenvironment-in-kidney-ischemia-reperfusion-injury
#14
Maithili Sashindranath, Karen M Dwyer, Shala Dezfouli, Carly Selan, Sandra Crikis, Bo Lu, Yuping Yuan, Michael J Hickey, Karlheinz Peter, Simon C Robson, Peter J Cowan, Harshal H Nandurkar
Kidney ischemia-reperfusion injury (IRI) is common during transplantation. IRI is characterised by inflammation and thrombosis and associated with acute and chronic graft dysfunction. P-selectin and its ligand PSGL-1 are cell adhesion molecules that control leukocyte-endothelial and leukocyte-platelet interactions under inflammatory conditions. CD39 is the dominant vascular nucleotidase that facilitates adenosine generation via extracellular ATP/ADP-phosphohydrolysis. Adenosine signalling is protective in renal IRI, but CD39 catalytic activity is lost with exposure to oxidant stress...
March 25, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28319748/modulation-of-vascular-function-and-anti-aggregation-effect-induced-by-1%C3%A2-3-1%C3%A2-6-%C3%AE-d-glucan-of-saccharomyces-cerevisiae-and-its-carboxymethylated-derivative-in-rats
#15
Lorena Soares Bezerra, Marciane Magnani, Raul Jorge Hernan Castro-Gomez, Hassler Clementino Cavalcante, Tays Amanda Felisberto da Silva, Renata Layne Paixão Vieira, Isac Almeida de Medeiros, Robson Cavalcante Veras
BACKGROUND: β-d-Glucans are polysaccharides found in the cell walls of yeasts, such as Saccharomyces cerevisiae, and they have been studied because of their beneficial effects on health, mainly in terms of immunomodulation. However, information on the action of these polymers on vascular and platelet function is still scarce. This study evaluate the effect of (1→3) (1→6) β-d-glucan (βG-Sc) and its carboxymethylated derivative (CM-G) on vascular and platelet function in rats. METHODS: The animals received daily oral treatments with βG-Sc (20mg/kg) and CM-G (20mg/kg) for eight days...
January 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28306357/asthma-causes-inflammation-of-human-pulmonary-arteries-and-decreases-vasodilatation-induced-by-prostaglandin-i2-analogs
#16
Nabil Foudi, Aouatef Badi, Mounira Amrane, Wassim Hodroj
OBJECTIVE: Asthma is a chronic inflammatory disease associated with increased cardiovascular events. This study assesses the presence of inflammation and the vascular reactivity of pulmonary arteries in patients with acute asthma. METHODS: Rings of human pulmonary arteries obtained from non-asthmatic and asthmatic patients were set up in organ bath for vascular tone monitoring. Reactivity was induced by vasoconstrictor and vasodilator agents. Protein expression of inflammatory markers was detected by western blot...
February 21, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28292763/oxygen-delivery-and-the-restoration-of-the-muscle-energetic-balance-following-exercise-implications-for-delayed-muscle-recovery-in-patients-with-copd
#17
Gwenael Layec, Corey R Hart, Joel D Trinity, Oh-Sung Kwon, Matthew J Rossman, Ryan M Broxterman, Yann Le Fur, Eun-Kee Jeong, Russell S Richardson
Patients with chronic obstructive pulmonary disease (COPD) experience a delayed recovery from skeletal muscle fatigue following exhaustive exercise that likely contributes to their progressive loss of mobility. As this phenomenon is not well understood, this study sought to examine post-exercise peripheral oxygen (O2) transport and muscle metabolism dynamics in patients with COPD, two important determinants of muscle recovery. Twenty four subjects, 12 non-hypoxemic patients with COPD and 12 healthy subjects with a sedentary lifestyle, performed dynamic plantar flexion exercise at 40% of maximal work rate (WRmax) with phosphorus magnetic resonance spectroscopy ((31)P-MRS), near-infrared spectroscopy (NIRS), and vascular Doppler ultrasound assessments...
March 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28290914/-nonplatelet-effects-of-ticagrelor
#18
V V Boiko, G N Soboleva
This review summarizes current knowledge concerning "nonplatelet effects of P2Y12 receptor antagonist ticagrelor. We show the experimental and clinical evidence that ticagrelor increases plasma concentration of adenosine as a potential mechanism of additive effects of ticagrelor. In addition, we sought to compare the clinical profile of ticagrelor with pharmacological effects of adenosine and discuss from this point of view the effects of ticagrelor on vascular tone, cardiac electrophysiology, ischemia/reperfusion injury, immunity and inflammatory reactions, peripheral nerves...
July 2016: Kardiologiia
https://www.readbyqxmd.com/read/28288160/efficient-and-robust-differentiation-of-endothelial-cells-from-human-induced-pluripotent-stem-cells-via-lineage-control-with-vegf-and-cyclic-amp
#19
Takeshi Ikuno, Hidetoshi Masumoto, Kohei Yamamizu, Miki Yoshioka, Kenji Minakata, Tadashi Ikeda, Ryuzo Sakata, Jun K Yamashita
Blood vessels are essential components for many tissues and organs. Thus, efficient induction of endothelial cells (ECs) from human pluripotent stem cells is a key method for generating higher tissue structures entirely from stem cells. We previously established an EC differentiation system with mouse pluripotent stem cells to show that vascular endothelial growth factor (VEGF) is essential to induce ECs and that cyclic adenosine monophosphate (cAMP) synergistically enhances VEGF effects. Here we report an efficient and robust EC differentiation method from human pluripotent stem cell lines based on a 2D monolayer, serum-free culture...
2017: PloS One
https://www.readbyqxmd.com/read/28278315/biochemical-effects-of-exercise-on-a-fasciocutaneous-flap-in-a-rat-model
#20
Edita Aksamitiene, Adam L Baker, Sudeep Roy, Salini Hota, Li-Hui Zhang, Julianna Rodin, Kealan Hobelmann, Jan B Hoek, Edmund A Pribitkin
Importance: An overwhelming amount of data suggest that cardiovascular exercise has a positive effect on the mind and body, although the precise mechanism is not always clear. Objective: To assess the clinical and biochemical effects of voluntary cardiovascular exercise on pedicled flaps in a rodent model. Design, Setting, and Participants: Eighteen adult Sprague-Dawley male rats were randomized into a resting animal group (RAG) (n=9) and an exercise animal group (EAG) (n=9) for 14 days (July 23, 2013, through July 30, 2013)...
March 9, 2017: JAMA Facial Plastic Surgery
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