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https://www.readbyqxmd.com/read/29448091/evidence-and-prospective-of-plant-derived-flavonoids-as-antiplatelet-agents-strong-candidates-to-be-drugs-of-future
#1
Harron Khan, Mohammad Jawad, Mohammad Ajmal Kamal, Alessandra Baldi, Jianbo Xiao, Seyed Mohammad Nabavi, Maria Daglia
Platelets are involved in hemostasis, inflammation, and thrombosis processes. Following a vascular damage, the endothelium releases protein factors, allowing the adhesion of subendothelium to platelets. Then platelets are activated, leading to the secretion of biologically-active ligands including thromboxane A2, adenosine diphosphate and serotonin. Aspirin, clopidogrel and warfarin are the most common drugs used to meet the challenges of platelet aggregation. However, these agents face issues with aspirin resistance and bleeding...
February 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29443732/curcumin-induces-apoptosis-and-inhibits-proliferation-in-infantile-hemangioma-endothelial-cells-via-downregulation-of-mcl-1-and-hif-1%C3%AE
#2
Suhui Lou, Yanfang Wang, Zujiang Yu, Kelei Guan, Quancheng Kan
BACKGROUND: Curcumin has been used as an alternative medicine for the treatment of infantile hemangiomas (IHs); however, the mechanism underlying the effectiveness of curcumin in IHs remains largely unclear. METHODS: In this study, we isolated primary human hemangioma endothelial cells (HemECs) from fresh surgical specimens of 3 patients. We treated HemECs by curcumin and investigated the alterations in proliferative and apoptotic signaling pathways with cell counting kit-8, flow cytometry, western blotting, immunofluorescence, and real-time polymerase chain reaction...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29439388/inhibitory-effect-of-flavonolignans-on-the-p2y12-pathway-in-blood-platelets
#3
Michal Bijak, Rafal Szelenberger, Angela Dziedzic, Joanna Saluk-Bijak
Adenosine diphosphate (ADP) is the major platelet agonist, which is important in the shape changes, stability, and growth of the thrombus. Platelet activation by ADP is associated with the G protein-coupled receptors P2Y1 and P2Y12. The pharmacologic blockade of the P2Y12 receptor significantly reduces the risk of peripheral artery disease, myocardial infarction, ischemic stroke, and vascular death. Recent studies demonstrated the inhibition of ADP-induced blood platelet activation by three major compounds of the flavonolignans group: silybin, silychristin, and silydianin...
February 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29439317/lumbar-sympathectomy-reduces-vascular-permeability-possibly-through-decreased-adenosine-receptor-a2a-expression-in-the-hind-plantar-skin-of-rats
#4
Zhifang Zheng, Yishu Liu, Lulu Zhu, Jianbing Tang, Wenhua Huang, Biao Cheng
BACKGROUND: The effect of lumbar sympathectomy for the treatment of lower limb ischemia remains a matter of controversy. METHODS: Sprague-Dawley rats were subjected to lumbar sympathectomy, after which Evans blue dye was injected into the hind plantar skin. Extravasation of dye was measured and compared with rats undergoing sham operation. Hind plantar skin was processed for HE staining, immunohistochemistry, and Western blot. RESULTS: In sympathectomized rats, blue stained areas in hind plantar skin and concentrations of Evans blue were significantly less than that of sham sympathectomy (control) rats, both 2 weeks and 3 months after surgery...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29433561/pregnancy-outcome-in-a-pregnant-patient-with-idiopathic-pulmonary-arterial-hypertension-a-case-report-and-review-of-the-literature
#5
Farid Rashidi, Hossein Sate
BACKGROUND: Idiopathic pulmonary arterial hypertension is a rare and progressive condition which is aggravated by the physiologic changes during pregnancy. Because of high mortality rate, most physicians recommend early termination of pregnancy in patients with idiopathic pulmonary arterial hypertension. CASE PRESENTATION: Here we describe a case of a 30-year-old primigravida Caucasian housewife with functional class 1 idiopathic pulmonary arterial hypertension and a positive vasoreactive response to adenosine who had a full-term non-complicated delivery...
February 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29424319/caffeine-inhibits-angiogenesis-in-human-glioblastoma-cells-via-hifs-modulation
#6
Grazia Maugeri, Agata Grazia D Amico, Daniela Maria Rasa, Salvatore Saccone, Concetta Federico, Gaetano Magro, Sebastiano Cavallaro, Velia D Agata
Caffeine represents the most used psychoactive drug in the world acting as a non-selective adenosine receptor antagonist. It exerts an anti-cancer role in glioblastoma multiforme (GBM). This neoplasia is characterized by extensive hypoxic foci triggering hypoxia-inducible factors (HIFs) expression. Among these factors, HIF-1α performs a crucial role in the induction of vascular endothelium growth factor (VEGF), a key player in angiogenesis and cell migration. In this work, we have investigated whether caffeine counteracts GBM progression by modulating hypoxic event...
February 9, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29417848/triiodothyronine-stimulates-vegf-expression-and-secretion-via-steroids-and-hif-1%C3%AE-in-murine-leydig-cells
#7
Bodhana Dhole, Surabhi Gupta, Senthil Kumar Venugopal, Anand Kumar
Leydig cells are the principal steroidogenic cells of the testis. Leydig cells also secrete a number of growth factors including vascular endothelial growth factor (VEGF) which has been shown to regulate both testicular steroidogenesis and spermatogenesis. The thyroid hormone, T3, is known to stimulate steroidogenesis in Leydig cells. T3 has also been shown to stimulate VEGF production in a variety of cell lines. However, studies regarding the effect of T3 on VEGF synthesis and secretion by the Leydig cells were lacking...
February 8, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29415954/antiplatelet-therapy-in-acs-patients-comparing-appropriate-p2y12-inhibition-by-clopidogrel-to-the-use-of-new-p2y12-inhibitors
#8
Jessica Ristorto, Nathan Messas, Benjamin Marchandot, Marion Kibler, Sébastien Hess, Nicolas Meyer, Michael Schaeffer, Nicolas Tuzin, Patrick Ohlmann, Laurence Jesel, Olivier Morel
AIM: In percutaneous coronary intervention (PCI)-treated acute coronary syndrome (ACS) patients on clopidogrel therapy, high on-treatment platelet adenosine diphosphate (ADP) reactivity was observed in numerous studies, with significant increases in non-fatal myocardial infarction, definite/probable stent thrombosis, or cardiovascular mortality. Compared to clopidogrel, prasugrel and ticagrelor provide more potent platelet inhibition. Whether new P2Y12 inhibitors reduce thrombotic events in a similar manner compared to the rate observed with appropriate P2Y12 inhibition by clopidogrel must still be determined...
February 8, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29402837/protective-effects-of-oxymatrine-on-vascular-endothelial-cells-from-high-glucose-induced-cytotoxicity-by-inhibiting-the-expression-of-a2b-receptor
#9
Yun Yi, Yulin Shen, Qin Wu, Jingan Rao, Shu Guan, Shenqiang Rao, Liping Huang, Mengxia Tan, Lingkun He, Lijuan Liu, Guodong Li, Shangdong Liang, Wei Xiong, Yun Gao
BACKGROUND/AIMS: Diabetes mellitus (DM) has become an increasingly epidemic metabolic disease. Vascular endothelial cells play a key role in developing the cardiovascular complications of DM. The A2B receptor is expressed in vascular endothelial cells, and may help regulate the function of endothelial cells. The aim of this study was to investigate the protective effects of oxymatrine (OMT) on human umbilical vein endothelial cells (HUVECs) from high glucose-induced cytotoxicity. METHODS: Homology modeling and molecular docking analysis were used to detect the binding sites between the adenosine A2B receptor and OMT...
January 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29401137/differential-effects-of-selective-and-nonselective-potassium-channel-inhibitors-in-ovine-endotoxemic-shock-macrocirculation-and-in-a-rat-model-of-septic-shock-microcirculation
#10
Michael Hessler, Bernardo B Pinto, Philip-Helge Arnemann, Tim-Gerald Kampmeier, Laura Seidel, Andrea Morelli, Hugo Van Aken, Martin Westphal, Sebastian Rehberg, Christian Ertmer
BACKGROUND: Potassium-(K)-channel inhibitors may increase systemic vascular resistance in vasodilatory shock states. OBJECTIVE: The purpose of the present study was to compare the macro- and microvascular effects of the adenosine triphosphate-sensitive K-channel-(KATP)-inhibitor glipizide and the nonselective K-channel inhibitor tetraethylammonium (TEA) in ovine endotoxemic shock and septic shock in rats. DESIGN: Two randomized, controlled laboratory studies...
February 2, 2018: Shock
https://www.readbyqxmd.com/read/29389548/optimal-conditions-for-cordycepin-production-in-surface-liquid-cultured-cordyceps-militaris-treated-with-porcine-liver-extracts-for-suppression-of-oral-cancer
#11
Liang-Tzung Lin, Ying-Jang Lai, She-Ching Wu, Wei-Hsuan Hsu, Chen-Jei Tai
Cordycepin is one of the most crucial bioactive compounds produced by Cordyceps militaris and has exhibited antitumor activity in various cancers. However, industrial production of large amounts of cordycepin is difficult. The porcine liver is abundant in proteins, vitamins, and adenosine, and these ingredients may increase cordycepin production and bioconversion during C. militaris fermentation. We observed that porcine liver extracts increased cordycepin production. In addition, air supply (2 h/d) significantly increased the cordycepin level in surface liquid-cultured C...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29382667/inhibiting-integrin-%C3%AE-5-cytoplasmic-domain-signaling-reduces-atherosclerosis-and-promotes-arteriogenesis
#12
Madhusudhan Budatha, Jiasheng Zhang, Zhen W Zhuang, Sanguk Yun, James E Dahlman, Daniel G Anderson, Martin A Schwartz
BACKGROUND: Fibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which inhibits anti-inflammatory cyclic adenosine monophosphate and protein kinase A. Replacing the α5 cytoplasmic domain with that of α2 resulted in smaller atherosclerotic plaques. Here, we further assessed plaque phenotype and compensatory vascular remodeling in this model...
January 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29373539/acute-limb-ischemia-much-more-than-just-a-lack-of-oxygen
#13
REVIEW
Florian Simon, Alexander Oberhuber, Nikolaos Floros, Albert Busch, Markus Udo Wagenhäuser, Hubert Schelzig, Mansur Duran
Acute ischemia of an extremity occurs in several stages, a lack of oxygen being the primary contributor of the event. Although underlying patho-mechanisms are similar, it is important to determine whether it is an acute or chronic event. Healthy tissue does not contain enlarged collaterals, which are formed in chronically malperfused tissue and can maintain a minimum supply despite occlusion. The underlying processes for enhanced collateral blood flow are sprouting vessels from pre-existing vessels (via angiogenesis) and a lumen extension of arterioles (via arteriogenesis)...
January 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29372854/adenosine-induced-cardiac-standstill-for-endovascular-treatment-of-pediatric-vein-of-galen-malformations
#14
Nam K Yoon, Jonathan P Scoville, Philipp Taussky
Vein of Galen malformations are congenital high-flow vascular malformations that often present with heart failure, hydrocephalus, developmental delay, and intracranial hemorrhage. Because open surgical treatment is associated with high morbidity and mortality, endovascular embolization is increasingly becoming the preferred method of intervention. However, embolization of these lesions can be difficult because of their high-flow nature. The use of adenosine-induced cardiac standstill for treatment of vein of Galen malformations has not been previously described in neonates...
January 26, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29371134/pericytes-constrict-blood-vessels-after-myocardial-ischemia
#15
REVIEW
Matheus A Costa, Ana E Paiva, Julia P Andreotti, Marcus V Cardoso, Carlos D Cardoso, Akiva Mintz, Alexander Birbrair
No-reflow phenomenon is defined as the reduced blood flow after myocardial ischemia. If prolonged it leads to profound damages in the myocardium. The lack of a detailed knowledge about the cells mediating no-reflow restricts the design of effective therapies. Recently, O'Farrell et al. (2017) by using state-of-the-art technologies, including high-resolution confocal imaging in combination with myocardial ischemia/reperfusion mouse model, reveal that pericytes contribute to the no-reflow phenomenon post-ischemia in the heart...
January 22, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29367584/cyclic-nucleotide-directed-protein-kinases-in-cardiovascular-inflammation-and-growth
#16
REVIEW
Nathan A Holland, Jake T Francisco, Sean C Johnson, Joshua S Morgan, Troy J Dennis, Nishitha R Gadireddy, David A Tulis
Cardiovascular disease (CVD), including myocardial infarction (MI) and peripheral or coronary artery disease (PAD, CAD), remains the number one killer of individuals in the United States and worldwide, accounting for nearly 18 million (>30%) global deaths annually. Despite considerable basic science and clinical investigation aimed at identifying key etiologic components of and potential therapeutic targets for CVD, the number of individuals afflicted with these dreaded diseases continues to rise. Of the many biochemical, molecular, and cellular elements and processes characterized to date that have potential to control foundational facets of CVD, the multifaceted cyclic nucleotide pathways continue to be of primary basic science and clinical interest...
January 23, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29367551/the-potential-of-a-novel-class-of-epac-selective-agonists-to-combat-cardiovascular-inflammation
#17
REVIEW
Graeme Barker, Euan Parnell, Boy van Basten, Hanna Buist, David R Adams, Stephen J Yarwood
The cyclic 3',5'-adenosine monophosphate (cAMP) sensor enzyme, EPAC1, is a candidate drug target in vascular endothelial cells (VECs) due to its ability to attenuate proinflammatory cytokine signalling normally associated with cardiovascular diseases (CVDs), including atherosclerosis. This is through the EPAC1-dependent induction of the suppressor of cytokine signalling gene, SOCS3, which targets inflammatory signalling proteins for ubiquitinylation and destruction by the proteosome. Given this important role for the EPAC1/SOCS3 signalling axis, we have used high throughput screening (HTS) to identify small molecule EPAC1 regulators and have recently isolated the first known non-cyclic nucleotide (NCN) EPAC1 agonist, I942...
December 5, 2017: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29357431/vascular-endothelial-cell-changes-in-post-cardiac-surgery-acute-kidney-injury
#18
Saqib H Qureshi, Nishith N Patel, Gavin J Murphy
BACKGROUND: Acute Kidney Injury (AKI) is common complication of cardiac surgery however the phenotype of this condition is poorly defined. The aim of this study was to characterize changes in endothelial structure and function that underlie post cardiopulmonary bypass (CPB) AKI. METHODS: Adult pigs (N=16) were randomised to undergo following procedures; (n=8 per group); Group 1: sham operation-neck dissection with 2.5hr of general anesthesia and Group 2: CPB-2.5hr of cardiopulmonary bypass...
December 20, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29353318/diagnostic-value-of-vascular-endothelial-growth-factor-transforming-growth-factor-%C3%AE-interleukin-8-and-the-ratio-of-lactate-dehydrogenase-to-adenosine-deaminase-in-pleural-effusion
#19
Takeshi Saraya, Kosuke Ohkuma, Takayasu Watanabe, Sunao Mikura, Fumi Kobayashi, Junpei Aso, Hiroki Nunokawa, Kojiro Honda, Yukari Ogawa, Masaki Tamura, Mitsuru Sada, Miku Oda, Manami Inoue, Takuma Yokoyama, Daisuke Kurai, Haruyuki Ishii, Hirokazu Kimura, Hajime Takizawa
PURPOSE: We studied the diagnostic value of cytokines, including vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and interleukin-8 (IL-8), and the ratio of lactate dehydrogenase (LDH) to adenosine deaminase (ADA) in pleural fluid. METHODS: Prospective analysis of 44 inpatients or outpatients with pleural fluid, from December 2016 to March 2017 was conducted. RESULTS: We enrolled patients with malignant pleural effusion (MPE, N = 15), empyema (N = 11), parapneumonic effusion (PPE, N = 7), chronic renal failure (CRF)/chronic heart failure (CHF) (N = 7), and tuberculous pleural effusion (TBPE, N = 4)...
January 20, 2018: Lung
https://www.readbyqxmd.com/read/29353219/blocking-mitochondrial-cyclophilin-d-ameliorates-tsh-impaired-defensive-barrier-of-artery
#20
Xiaojing Liu, Heng Du, Qiang Chai, Qing Jia, Lu Liu, Meng Zhao, Jun Li, Hui Tang, Wenbin Chen, Lifang Zhao, Li Fang, Ling Gao, Jiajun Zhao
AIMS: Endothelial cells (ECs) constitute the defensive barrier of vasculature, which maintains the vascular homeostasis. Mitochondrial oxidative stress (mitoOS) in ECs significantly affects the initiation and progression of vascular diseases. The higher serum thyroid stimulating hormone (TSH) level is being recognized as a nonconventional risk factor responsible for the increased risk of cardiovascular diseases in subclinical hypothyroidism (SCH). However, effects and underlying mechanisms of elevated TSH on ECs are still ambiguous...
January 9, 2018: Redox Biology
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