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https://www.readbyqxmd.com/read/29786960/the-atomic-resolution-structure-of-a-class-c-%C3%AE-lactamase-and-of-its-complex-with-avibactam
#1
Stefano Mangani, Cecilia Pozzi, Flavio Di Pisa, Filomena De Luca, Manuela Benvenuti, Jean-Denis Docquier
β-lactamases (BLs) are important antibiotic resistance determinants that significantly compromise the efficacy of valuable β-lactam antibacterial drugs. For that reason, combinations with β-lactamase inhibitor were developed. Avibactam is the first non-β-lactam BL inhibitor introduced in clinical practice. Ceftazidime-avibactam represents one of the few last-resort antibiotics available for the treatment of infections caused by near pandrug-resistant bacteria. TRU-1 is a chromosomally-encoded AmpC-type BL of Aeromonas enteropelogenes, related to the FOX-type BLs and constitutes a good model for class C BLs...
May 22, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29786865/infection-with-phytopathogenic-bacterium-inhibits-melatonin-biosynthesis-decreases-longevity-of-its-vector-and-suppresses-the-free-radical-defense
#2
Yasser Nehela, Nabil Killiny
Vector-borne phytopathogenic bacteria may alter the reproductive fitness, survival, behavior, and metabolism of their vectors. Candidatus Liberibacter asiaticus (CLas) is associated with the Huanglongbing (HLB; also known as citrus greening disease), one of the most destructive citrus diseases worldwide, and transmitted by Asian citrus psyllid, Diaphorina citri (Insecta, Hemiptera, Liviidae). The genome sequencing of CLas revealed that it does not have the ability to synthesize tryptophan, the precursor of melatonin, and it must acquire it from its host plant or insect vector to achieve its biological processes, such as growth and multiplication...
May 22, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29786655/bioactive-pyridone-alkaloids-from-a-deep-sea-derived-fungus-arthrinium-sp-ujnmf0008
#3
Jie Bao, Huijuan Zhai, Kongkai Zhu, Jin-Hai Yu, Yuying Zhang, Yinyin Wang, Cheng-Shi Jiang, Xiaoyong Zhang, Yun Zhang, Hua Zhang
Eight new 4-hydroxy-2-pyridone alkaloids arthpyrones D⁻K ( 1 ⁻ 8 ), along with two known analogues apiosporamide ( 9 ) and arthpyrone B ( 10 ), were isolated from a deep-sea-derived fungus Arthrinium sp. UJNMF0008. The structures of the isolated compounds were elucidated on the basis of spectroscopic methods with that of 1 being established by chemical transformation and X-ray diffraction analysis. Compounds 1 and 2 bore an ester functionality linking the pyridone and decalin moieties first reported in this class of metabolites, while 3 and 4 incorporated a rare natural hexa- or tetrahydrobenzofuro[3,2- c ]pyridin-3(2 H )-one motif...
May 22, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29786436/cytotoxic-and-antibacterial-eremophilane-sesquiterpenes-from-the-marine-derived-fungus-cochliobolus-lunatus-scsio41401
#4
Wei Fang, Jianjiao Wang, Junfeng Wang, Liqiao Shi, Kunlong Li, Xiuping Lin, Yong Min, Bin Yang, Lan Tang, Yonghong Liu, Xuefeng Zhou
Three new eremophilane sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 μM) and three bacterial species (MIC 1.5 to 13 μg/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3...
May 22, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29785743/four-new-diterpenoid-alkaloids-from-the-roots-of-aconitum-carmichaelii
#5
Yu Li, Feng Gao, Ji-Fa Zhang, Xian-Li Zhou
Aconitum carmichaelii, belonging to the Ranunculaceae family, is mainly distributed and cultivated in southwestern China. Its parent and lateral roots, two well-known traditional medicinal materials, are commonly called as "Chuanwu" and "Fuzi" in China, respectively. A. carmichaelii is widely used for the treatment of cadianeuria, neuralgia, and rheumatalgia in Chinese medicine. According to the pharmacology studies, diterpenoid alkaloids accounted for the major effects and toxicity of this plant, such as hypaconitine, mesaconitine, aconitine...
May 21, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29785482/characterization-and-antimicrobial-property-of-some-heavy-metals-containing-ayurvedic-drugs
#6
Prasamsha Panta, Tika Ram Bhandari, Bidit Lamsal, Rameshwar Adhikari
Ayurvedic medicines are often used in different formulations, the heavy metals, which are generally referred to as being toxic. In this work, we report on the physicochemical characterization and biological activity of some typical Ayurvedic drugs available in the market that contain arsenic, mercury and lead with the emphasis on their antibacterial performance. Among the formulations studied, some of the drugs with 'amorphous' texture (and higher solubility) were found quite active against some bacterial strains whereas the formulations possessing crystalline texture (and low solubility) were found practically ineffective...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29784887/identification-of-the-thioredoxin-partner-of-vkor-in-mycobacterial-disulfide-bond-formation
#7
Na Ke, Cristina Landeta, Xiaoyun Wang, Dana Boyd, Markus Eser, Jon Beckwith
Disulfide bonds influence stability and activity of many proteins. In Escherichia coli the DsbA and DsbB enzymes promote disulfide bond formation. Other bacteria, including the Actinobacteria, use instead of DsbB the enzyme VKOR (Vitamin K Epoxide Reductase), which is found either fused to or encoded in the same operon as a dsbA -like protein. Mycobacterium tuberculosis and other gram-positive Actinobacteria secrete to the cell envelope many proteins with even numbers of cysteines. These organisms have predicted oxidoreductases and VKOR orthologs...
May 21, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29784878/oxidative-decarboxylation-of-pyruvate-by-1-deoxy-d-xyulose-5-phosphate-synthase-a-central-metabolic-enzyme-in-bacteria
#8
Alicia A DeColli, Natasha S Nemeria, Ananya Majumdar, Gary J Gerfen, Frank Jordan, Caren L Freel Meyers
The underexploited antibacterial target 1-deoxy-D-xyluose 5-phosphate (DXP) synthase, catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and D-glyceraldehyde 3-phosphate (D-GAP). DXP is an essential intermediate in the biosynthesis of ThDP, pyridoxal phosphate, and isoprenoids in many pathogenic bacteria. DXP synthase catalyzes a distinct mechanism in ThDP decarboxylative enzymology in which the first enzyme-bound pre-decarboxylation intermediate, C2α-lactylThDP (LThDP), is stabilized by DXP synthase in the absence of D-GAP, and D-GAP then induces efficient LThDP decarboxylation...
May 21, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29784273/halogenated-trimethoprim-derivatives-as-multidrug-resistant-staphylococcus-aureus-therapeutics
#9
Napon Nilchan, Wanida Phetsang, Taechin Nowwarat, Soraya Chaturongakul, Chutima Jiarpinitnun
Incorporation of halogen atoms to drug molecule has been shown to improve its properties such as enhanced in membrane permeability and increased hydrophobic interactions to its target. To investigate the effect of halogen substitutions on the antibacterial activity of trimethoprim (TMP), we synthesized a series of halogen substituted TMP and tested for their antibacterial activities against global predominant methicillin resistant Staphylococcus aureus (MRSA) strains. Structure-activity relationship analysis suggested a trend in potency that correlated with the ability of the halogen atom to facilitate in hydrophobic interaction to saDHFR...
May 19, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29783786/graphene-based-nanomaterials-for-tissue-engineering-in-the-dental-field
#10
REVIEW
Riccardo Guazzo, Chiara Gardin, Gloria Bellin, Luca Sbricoli, Letizia Ferroni, Francesco Saverio Ludovichetti, Adriano Piattelli, Iulian Antoniac, Eriberto Bressan, Barbara Zavan
The world of dentistry is approaching graphene-based nanomaterials as substitutes for tissue engineering. Apart from its exceptional mechanical strength, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized with several bioactive molecules. They can also be incorporated into different scaffolds used in regenerative dentistry, generating nanocomposites with improved characteristics. This review presents the state of the art of graphene-based nanomaterial applications in the dental field...
May 20, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29783167/removing-escherichia-coli-from-water-using-zinc-oxide-coated-zeolite
#11
Lingling Wang, Wenlin Wu, Xiaolan Xie, Hongbin Chen, Jianming Lin, Dionysios D Dionysiou
The removal of Escherichia coli (E. coli) from water by zinc oxide-coated zeolite (ZOCZ) and ZOCZ's antibacterial properties were examined in laboratory experiments using plate counting method and tests of cell apoptosis. Batch experiments showed that ZOCZ has a maximum removal capacity for E. coli of about 4.34 × 106  CFU g-1  at 25 °C. Element mappings confirm that zinc ions accumulate in the E. coli cells causing cell death. Pseudo-second-order kinetics and Freundlich isotherms were found to best describe the removal of E...
May 11, 2018: Water Research
https://www.readbyqxmd.com/read/29782987/chitin-silk-fibroin-tio-2-bio-nanocomposite-as-a-biocompatible-wound-dressing-bandage-with-strong-antimicrobial-activity
#12
Mojtaba Ghanbari Mehrabani, Ramin Karimian, Rasul Rakhshaei, Farzaneh Pakdel, Hosein Eslami, Vahid Fakhrzadeh, Mahdi Rahimi, Roya Salehi, Hossein Samadi Kafil
Interconnected microporous biodegradable and biocompatible chitin/silk fibroin/TiO2 nanocomposite wound dressing with high antibacterial, blood clotting and mechanical strength properties were synthesized using freeze-drying method. The prepared nanocomposite dressings were characterized using SEM, FTIR, and XRD analysis. The prepared nanocomposite dressings showed high porosity above 90% with well-defined interconnected porous construction. Swelling and water uptake of the dressing were 93%, which is great for wound dressing applications...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782965/membrane-cholesterol-delays-cellular-apoptosis-induced-by-ginsenoside-rh2-a-steroid-saponin
#13
Sandrine L Verstraeten, Marie Albert, Adrien Paquot, Giulio G Muccioli, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq
Saponins exhibit several biological and pharmacological activities, such as antibacterial, anti-inflammatory and anticancer effects. Many studies attribute their activities to their interactions with cholesterol. In this study, we focus on the steroid saponin ginsenoside Rh2, one of the active principles of Panax ginseng root. Some evidence suggests that lipid rafts, defined as nanodomains enriched in cholesterol and sphingolipids, could be involved in the Rh2-induced apoptosis. However, the role of membrane lipids, especially cholesterol, in this process is still poorly understood...
May 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29782890/novel-dental-adhesive-resin-with-crack-self-healing-antimicrobial-and-remineralization-properties
#14
Shichao Yue, Junling Wu, Qiang Zhang, Ke Zhang, Michael D Weir, Satoshi Imazato, Yuxing Bai, Hockin H K Xu
OBJECTIVES: Secondary caries at the tooth-restoration margins is a primary reason for restoration failure. Cracks at the margins lead to leakage which can trap bacteria, producing acids to cause caries. To date, there has been no report on developing an adhesive resin that has self-healing, antibacterial and remineralizing capabilities. The objectives of this study were to: (1) develop the first self-healing adhesive with antimicrobial and remineralizing capabilities, and (2) investigate the effects of incorporating microcapsules, dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP) for the first time...
May 18, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29782792/antimicrobial-properties-of-2d-mno-2-and-mos-2-nanomaterials-vertically-aligned-on-graphene-materials-and-ti-3-c-2-mxene
#15
Farbod Alimohammadi, Mohammad Sharifian Gh, Nuwan H Attanayake, Akila C Thenuwara, Yury Gogotsi, Babak Anasori, Daniel R Strongin
Two dimensional (2D) nanomaterials have attracted considerable attention in biomedical and environmental applications due to their antimicrobial activity. In the interest of investigating the primary antimicrobial mode-of-action of 2D nanomaterials, we studied the antimicrobial properties of MnO2 and MoS2 , toward Gram-positive and Gram-negative bacteria. Bacillus subtilis and Escherichia coli bacteria were treated individually with 100 μg/mL of randomly oriented and vertically aligned nanomaterials for 3 h in the dark...
May 21, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29782697/fewer-defects-in-the-surface-slows-the-hydrolysis-rate-decreases-the-ros-generation-potential-and-improves-the-non-ros-antimicrobial-activity-of-mgo
#16
Nemanja Anicˇić, Marija Vukomanović, Tilen Koklicˇ, Danilo Suvorov
Magnesium oxide (MgO) is recognised as exhibiting a contact-based antibacterial activity. However, a comprehensive study of the impact of atomic-scale surface features on MgO's antibacterial activity is lacking. In this study, the nature and abundance of the native surface defects on different MgO powders are thoroughly investigated. Their impacts on the hydrolysis kinetics, antibacterial activity against Escherichia coli (ATCC 47076), Staphylococcus epidermidis and Pseudomonas aeruginosa and the reactive oxygen species (ROS) generation potential are determined and explained...
May 21, 2018: Small
https://www.readbyqxmd.com/read/29782695/dual-ag-zno-decorated-micro-nanoporous-sulfonated-polyetheretherketone-with-superior-antibacterial-capability-and-biocompatibility-via-layer-by-layer-self-assembly-strategy
#17
Yi Deng, Lei Yang, Xiaobing Huang, Junhong Chen, Xiuyuan Shi, Weizhong Yang, Min Hong, Yuan Wang, Matthew S Dargusch, Zhi-Gang Chen
Polyetheretherketone is attractive for dental and orthopedic applications due to its mechanical attributes close to that of human bone; however, the lack of antibacterial capability and bioactivity of polyetheretherketone has substantially impeded its clinical applications. Here, a dual therapy implant coating is developed on the 3D micro-/nanoporous sulfonated polyetheretherketone via layer-by-layer self-assembly of Ag ions and Zn ions. Material characterization studies have indicated that nanoparticles consisting of elemental Ag and ZnO are uniformly incorporated on the porous sulfonated polyetheretherketone surface...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29782651/pharmacokinetic-and-metabolism-studies-of-bavachinin-through-ultra-high-performance-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry
#18
Jun Qian, Fan Xie, Yanhong Shi, Jinhang Li, Liuqiang Zhang, Yiming Li, Fujiang Guo, Rui Wang
Bavachinin (BVC), one of the main bioactive prenylated flavonoids derived from Psoralea corylifolia Linn, has a wide variety of pharmacological effects, such as antiangiogenic, antitumour, antiallergic, anti-inflammatory, and antibacterial activities, especially as a pan-peroxisome proliferator-activated receptors (PPARs) agonist. A rapid and sensitive method for quantifying BVC in rat plasma was developed and validated through ultra-high-performance liquid chromatography coupled with electrospray-ionization tandem mass spectrometry...
May 21, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29782471/new-approach-in-acne-therapy-a-specific-bacteriocin-activity-and-a-targeted-anti-il-8-property-in-just-1-probiotic-strain-the-l-salivarius-ls03
#19
Francesca Deidda, Angela Amoruso, Stefania Nicola, Teresa Graziano, Marco Pane, Luca Mogna
GOALS: The aim of this research was to assess the antibacterial activity of Lactobacillus salivarius LS03 (DSM 22776) against Propionibacterium acnes and its anti-inflammatory properties by inhibiting P. acnes-induced interleukin-8 (IL-8) release. BACKGROUND: Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics, have limited use. Thus, development of novel agents to treat this disease is needed...
May 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29782305/tatami-mats-a-source-of-pitted-keratolysis-in-a-martial-arts-athlete
#20
Anamaria Balić, Zrinka Bukvić Mokos, Branka Marinović, Daniela Ledić Drvar
Dear Editor, Pitted keratolysis (PK), also known as keratosis plantaris sulcatum, is a non-inflammatory, bacterial, superficial cutaneous infection, characterized by many discrete superficial crateriform ''pits'' and erosions in the thickly keratinized skin of the weight-bearing regions of the soles of the feet (1). The disease often goes unnoticed by the patient, but when it is noticed it is because of the unbearable malodor and hyperhidrosis of the feet, which are socially unacceptable and cause great anxiety to many of the patients...
April 2018: Acta Dermatovenerologica Croatica: ADC
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