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https://www.readbyqxmd.com/read/27882833/evaluation-of-real-world-experience-with-tofacitinib-compared-with-adalimumab-etanercept-and-abatacept-in-ra-patients-with-1-previous-biologic-dmard-data-from-a-u-s-administrative-claims-database
#1
James Harnett, Robert Gerber, David Gruben, Andrew S Koenig, Connie Chen
BACKGROUND: Real-world data comparing tofacitinib with biologic disease-modifying antirheumatic drugs (bDMARDs) are limited. OBJECTIVE: To compare characteristics, treatment patterns, and costs of patients with rheumatoid arthritis (RA) receiving tofacitinib versus the most common bDMARDs (adalimumab [ADA], etanercept [ETN], and abatacept [ABA]) following a single bDMARD in a U.S. administrative claims database. METHODS: This study was a retrospective cohort analysis of patients aged ≥ 18 years with an RA diagnosis (ICD-9-CM codes 714...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27764096/a-large-genome-wide-association-study-of-age-related-hearing-impairment-using-electronic-health-records
#2
Thomas J Hoffmann, Bronya J Keats, Noriko Yoshikawa, Catherine Schaefer, Neil Risch, Lawrence R Lustig
Age-related hearing impairment (ARHI), one of the most common sensory disorders, can be mitigated, but not cured or eliminated. To identify genetic influences underlying ARHI, we conducted a genome-wide association study of ARHI in 6,527 cases and 45,882 controls among the non-Hispanic whites from the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. We identified two novel genome-wide significant SNPs: rs4932196 (odds ratio = 1.185, p = 4.0x10-11), 52Kb 3' of ISG20, which replicated in a meta-analysis of the other GERA race/ethnicity groups (1,025 cases, 12,388 controls, p = 0...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27737326/effects-of-vitamin-d-supplementation-on-pulmonary-function-in-postmenopausal-women-following-an-aquatic-exercise-program
#3
Rodrigo Nolasco, Linda D F Moreira, Danilo S Bocalini, Fernanda C A O Fronza, Rosangela Villa Marin, Marise Lazaretti-Castro
Objective: This study sought to investigate the effects of vitamin D supplementation and aquatic exercise on pulmonary function in postmenopausal women. Materials and methods: This prospective and controlled study included 104 women (62 ± 6.5 years) divided into three groups: a control group lacking vitamin D and calcium supplementation which remained sedentary (CG; n = 17); a control group receiving vitamin D and calcium supplementation which remained sedentary (CDG, n = 33); and a group that completed aquatic exercises three times a week and received vitamin D and calcium supplementation (DTG, n = 54)...
October 10, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27634245/basis-set-convergence-of-ccsd-t-equilibrium-geometries-using-a-large-and-diverse-set-of-molecular-structures
#4
Peter R Spackman, Dylan Jayatilaka, Amir Karton
We examine the basis set convergence of the CCSD(T) method for obtaining the structures of the 108 neutral first- and second-row species in the W4-11 database (with up to five non-hydrogen atoms). This set includes a total of 181 unique bonds: 75 H-X, 49 X-Y, 43 X=Y, and 14 X≡Y bonds (where X and Y are first- and second-row atoms). As reference values, geometries optimized at the CCSD(T)/aug'-cc-pV(6+d)Z level of theory are used. We consider the basis set convergence of the CCSD(T) method with the correlation consistent basis sets cc-pV(n+d)Z and aug'-cc-pV(n+d)Z (n = D, T, Q, 5) and the Weigend-Ahlrichs def2-n ZVPP basis sets (n = T, Q)...
September 14, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27472763/chondrocyte-morphology-in-stiff-and-soft-agarose-gels-and-the-influence-of-foetal-calf-serum
#5
A Karim, A C Hall
Changes to chondrocyte volume/morphology may have deleterious effects on extracellular matrix (ECM) metabolism potentially leading to cartilage deterioration and osteoarthritis (OA). The factors controlling chondrocyte properties are poorly understood however pericellular matrix (PCM) weakening may be involved. We have studied the density, volume, morphology and clustering of cultured bovine articular chondrocytes within stiff (2%w/v) and soft (0.2%w/v) 3-dimensional agarose gels. Gels with encapsulated chondrocytes were cultured in Dulbecco's Modified Eagle's Medium (DMEM; foetal calf serum (FCS) 1-10%;380mOsm) for up to 7d...
July 29, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27390994/post-operative-atrial-fibrillation-is-associated-with-a-pre-existing-structural-and-electrical-substrate-in-human-right-atrial-myocardium
#6
Junaid A B Zaman, Leanne Harling, Hutan Ashrafian, Ara Darzi, Nigel Gooderham, Thanos Athanasiou, Nicholas S Peters
BACKGROUND: Post-operative atrial fibrillation (POAF) is a major health economic burden. However, the precise mechanisms in POAF remain unclear. In other forms of AF, sites of high dominant frequency (DF) in sinus rhythm (SR) may harbour 'AF nests'. We studied AF inducibility in relation to substrate changes using epicardial electrograms and cardiomyocyte calcium handling in the atria of AF naïve patients. METHOD: Bipolar electrograms were recorded from the lateral right atrial (RA) wall in 34 patients undergoing coronary surgery using a high-density array in sinus rhythm (NSR)...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27318111/hematological-differences-among-malaria-patients-in-rural-and-urban-ghana
#7
Shareen A Iqbal, Felix Botchway, Kingsley Badu, Nana O Wilson, Yvonne Dei-Adomakoh, Carmen M Dickinson-Copeland, Helena Chinbuah, Andrew A Adjei, Michael Wilson, Jonathan K Stiles, Adel Driss
BACKGROUND: Scarce studies have addressed hematological differences of malaria in urban and rural regions. METHODS: Full or complete blood cell counts from 46 and 75 individuals (age range from < 1 to 92 years) with uncomplicated malaria infection living in urban (Accra) and rural (Dodowa) Ghana, respectively, were assessed. Sickle cell trait and patients were excluded from the study. RESULTS: Between overall groups, patients from Accra had significantly lower parasite count (p < 0...
June 17, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27312738/relation-of-cerebral-vessel-disease-to-alzheimer-s-disease-dementia-and-cognitive-function-in-elderly-people-a-cross-sectional-study
#8
Zoe Arvanitakis, Ana W Capuano, Sue E Leurgans, David A Bennett, Julie A Schneider
BACKGROUND: Few data on the pathology of cerebral vessel disease, dementia, and cognition are available. We examined the association of cerebral atherosclerosis and arteriolosclerosis neuropathology with probable and possible Alzheimer's disease dementia and cognitive function. METHODS: This cross-sectional study included men and women aged 65 years or older who had yearly clinical assessments and had agreed to brain autopsy at the time of death, as part of one of two cohort studies of ageing (The Religious Orders Study and the Rush Memory and Aging Project)...
August 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27220593/pulmonary-artery-pressure-guided-heart-failure-management-reduces-30-day-readmissions
#9
Philip B Adamson, William T Abraham, Lynne Warner Stevenson, Akshay S Desai, JoAnn Lindenfeld, Robert C Bourge, Jordan Bauman
BACKGROUND: This study examines the impact of pulmonary artery pressure-guided heart failure (HF) care on 30-day readmissions in Medicare-eligible patients. METHODS AND RESULTS: The CardioMicroelectromechanical system (CardioMEMS) Heart Sensor Allows Monitoring of Pressures to Improve Outcomes in New York Heart Association Class III Heart Failure Patients (CHAMPION) Trial included 550 patients implanted with a permanent MEMS-based pressure sensor in the pulmonary artery...
June 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27180576/genetic-identification-of-spirometra-decipiens-plerocercoids-in-terrestrial-snakes-from-korea-and-china
#10
Hyeong-Kyu Jeon, Hansol Park, Dongmin Lee, Seongjun Choe, Kyu-Heon Kim, Woon-Mok Sohn, Keeseon S Eom
Human sparganosis is a zoonotic disease caused by infection with larval forms (procercoid/plerocercoid) of Spirometra spp. The purpose of this study was to identify Spirometra spp. of infected snakes using a multiplex PCR assay and phylogenetic analysis of mitochondrial DNA sequence data from the spargana of terrestrial snakes obtained from Korea and China. A total of 283 snakes were obtained that included 4 species of Colubridae comprising Rhabdophis tigrinus tigrinus (n=150), Dinodon rufozonatum rufozonatum (n=64), Elaphe davidi (n=2), and Elaphe schrenkii (n=7), and 1 species of Viperidae, Agkistrodon saxatilis (n=60)...
April 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27160558/simultaneous-measurement-of-friction-and-wear-in-hip-simulators
#11
Hani Haider, Joel N Weisenburger, Kevin L Garvin
We propose and have evaluated a method to measure hip friction during wear testing on a popular multi-station hip simulator. A 6-degree-of-freedom load cell underneath the specimen sensed forces and torques during implant wear testing of simulated walking. This included internal-external and adduction-abduction rotations which are often neglected during friction testing on pendulum-type machines. Robust mathematical analysis and data processing provided friction estimates in three simultaneous orthogonal rotations, over extended multi-million cycle wear tests...
May 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/26981606/mechanical-properties-of-orthodontic-thermoplastics-petg-pc2858-after-blending
#12
COMPARATIVE STUDY
Yan Song Ma, Dong Yu Fang, Ning Zhang, Xue Jia Ding, Kun Ya Zhang, Yu Xing Bai
OBJECTIVE: To characterise and compare the tensile characteristics after multi-proportional blending, to determine the proper blending ratio for new thermoplastic material and to compare its mechanical performance with commercial thermoplastics. METHODS: PETG and PC2858 aggregates were blended in five different ratios. Standard specimens of each ratio were molded and tested to determine their mechanical performance. Then the new material with the proper blending ratio was chosen and compared against commercial thermoplastics...
March 2016: Chinese Journal of Dental Research
https://www.readbyqxmd.com/read/26960368/association-between-dentin-matrix-protein-1-rs10019009-polymorphism-and-ankylosing-spondylitis-in-a-chinese-han-population-from-shandong-province
#13
Jian-Min Liu, Ya-Zhou Cui, Geng-Lin Zhang, Xiao-Yan Zhou, Jing-Xiang Pang, Xue-Zheng Wang, Jin-Xiang Han
BACKGROUND: Ankylosing spondylitis (AS) is the most common rheumatic condition that is slowly progressive and predominantly affects adolescents. Pathological bone formation associated with AS is an important cause of disability. The aim of the study was to investigate the possible involvement of the genes related to endochondral ossification and ectopia ossification in genetic susceptibility to AS in a Chinese Han population. METHODS: Sixty-eight single nucleotide polymorphisms (SNPs) from 13 genes were genotyped in discovery cohorts including 300 AS patients and 180 healthy controls...
March 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/26948379/increased-amyloidogenic-app-processing-in-apoe-%C3%A9-4-negative-individuals-with-cerebral-%C3%AE-amyloidosis
#14
Niklas Mattsson, Philip S Insel, Sebastian Palmqvist, Erik Stomrud, Danielle van Westen, Lennart Minthon, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Increased APP (amyloid precursor protein) processing causes β-amyloid (Aβ) accumulation in autosomal dominant Alzheimer's disease (AD), but it is unclear if it also affects sporadic Aβ accumulation. We tested healthy controls and patients with mild cognitive symptoms (N=331) in the BioFINDER study, using cerebrospinal fluid (CSF) Aβ40 as a surrogate for amyloidogenic APP processing. We find that levels of brain Aβ fibrils (measured by 18F-flutemetamol PET) are independently associated with high CSF Aβ40 (P<0...
March 7, 2016: Nature Communications
https://www.readbyqxmd.com/read/26851024/high-ptprq-expression-and-its-relationship-to-expression-of-ptprz1-and-the-presence-of-kras-mutations-in-colorectal-cancer-tissues
#15
Izabela Laczmanska, Pawel Karpinski, Justyna Gil, Lukasz Laczmanski, Marek Bebenek, Maria M Sasiadek
BACKGROUND: The risk of sporadic colorectal cancer (CRC) is strongly influenced by Iifestyle, environmental and genetic factors. Protein tyrosine phosphatases belong to a group of enzymes whose role in CRC has not yet been intensively studied. They play an important role in activation/de-activation of many enzymes, influencing cell biology by catalyzing reactions opposing those catalyzed by kinases. Protein tyrosine phosphatase receptor-like type Q (PTPRQ) and protein tyrosine phosphatase receptor-like type Z polypeptide 1 (PTPRZ1) have both been shown to be important in development of many cancer types including CRC...
February 2016: Anticancer Research
https://www.readbyqxmd.com/read/26807242/clinical-characteristics-and-prognostic-analysis-of-krukenberg-tumor
#16
Fang Wu, Xiaoai Zhao, Baibing Mi, L U Feng, N A Yuan, Fuxi Lei, Min Li, Xinhan Zhao
Krukenberg tumor is a rare metastastic tumor of the ovary, characterized by poor prognosis. In order to analyze the clinical characteristics and prognostic factors, we retrospectively investigated 128 patients who were diagnosed with Krukenberg tumor between January, 1990 and December, 2010. The median patient age was 48 years. The median overall survival (OS) of Krukenberg tumor for all patients was 16 months (95% CI: 15-19 months). The median OS among patients with Krukenberg tumors of gastric, colorectal, breast and other origins (including appendix, gallbladder, small intestine and unknown primary) was 11, 21...
November 2015: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/26803710/electroconvulsive-therapy-clinical-database-influence-of-age-and-gender-on-the-electrical-charge
#17
Javier Salvador Sánchez, Mónica Delia David, Aurora Torrent Setó, Montserrat Martínez Alonso, Maria J Portella Moll, Josep Pifarré Paredero, Eduard Vieta Pascual, María Mur Laín
INTRODUCTION: The influence of age and gender in the electrical charge delivered in a given population was analysed using an electroconvulsive therapy (ECT) clinical database. MATERIAL AND METHOD: An observational, prospective, longitudinal study with descriptive analysis was performed using data from a database that included total bilateral frontotemporal ECT carried out with a Mecta spECTrum 5000Q(®) in our hospital over 6 years. From 2006 to 2012, a total of 4,337 ECT were performed on 187 patients...
January 20, 2016: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/26568740/surgeon-personality-is-associated-with-recommendation-for-operative-treatment
#18
Teun Teunis, Stein J Janssen, Thierry G Guitton, Ana-Maria Vranceanu, Bert Goos, David Ring
PURPOSE: When surgeons disagree about the role of surgery, patient values and preferences should drive decision-making, but there is evidence that surgeon preferences have substantial influence. Surgeon preferences may relate to surgeon personality. Our primary null hypothesis is that specific personality characteristics (work styles) are not associated with the recommendation for operative treatment accounting for surgeon demographics. PATIENTS AND METHODS: We invited members of the Science of Variation Group to assess images of 15 upper extremity injuries with debatable indications for surgery, recommended operative or non-operative treatment, and grade their confidence in this decision (n = 270); subsequently, participants completed the validated Octogram Work and Leadership Style Test (n = 223)...
December 2015: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/26529042/quantifying-ocular-surface-inflammation-and-correlating-it-with-inflammatory-cell-infiltration-in-vivo-a-novel-method
#19
Giulio Ferrari, Alessandro Rabiolo, Fabio Bignami, Federico Sizzano, Alessio Palini, Chiara Villa, Paolo Rama
PURPOSE: The purpose of this study was to develop a novel, objective, and semiautomated method to quantify conjunctival redness by correlating measured redness with standard clinical redness and symptom scales and inflammatory cell infiltration. METHODS: Eleven outpatients presenting with mild to severe conjunctival hyperemia were included in the study. Clinical examination included patient history; visual analogue score (VAS) for ocular symptoms; 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ 25) for quality of life/vision; photographs of the anterior segment graded for conjunctival hyperemia, using Efron, relative redness of image (RRI), and edge feature (EF) scales; and conjunctival impression cytology analyzed by flow cytometry...
November 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26505550/survival-prediction-in-patients-undergoing-open-heart-mitral-valve-operation-after-previous%C3%A2-failed-mitraclip-procedures
#20
Stephan Geidel, Peter Wohlmuth, Michael Schmoeckel
BACKGROUND: The objective of this study was to analyze the results of open heart mitral valve operations for survival prediction in patients with previously unsuccessful MitraClip procedures. METHODS: Thirty-three consecutive patients who underwent mitral valve surgery in our institution were studied. At a median of 41 days, they had previously undergone one to five futile MitraClip implantations. At the time of their operations, patients were 72.6 ± 10.3 years old, and the calculated risk, using the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II, was a median of 26...
March 2016: Annals of Thoracic Surgery
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