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https://www.readbyqxmd.com/read/28591361/doppler-velocimetry-in-fetal-rats-exposed-to-enoxaparin-and-unfractionated-heparin-ufh-during-pregnancy
#1
Flavio Renato de Almeida Senefonte, Ricardo Dutra Aydos, Vanessa Marcon de Oliveira, Marco Antonio Costa Bósio, Ernesto Antonio Figueiró-Filho
Purpose: To evaluate the effects of enoxaparin and unfractionated heparin (UFH) administered in prophylactic and therapeutic doses on fetal vessels in healthy pregnant Wistar rats, according to Doppler velocimetry measurements. Methods: Fifty animals were assigned to one of five groups: controls (saline), prophylactic and therapeutic enoxaparin (1 and 2 mg/kg/day, respectively), and prophylactic and therapeutic UFH (72 and 400 UI/kg/day, respectively). Uterine horns were examined by ultrasound for identification of live fetuses...
May 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28587605/evaluation-of-arterial-digital-blood-flow-using-doppler-ultrasonography-in-healthy-dairy-cows
#2
H Müller, M Heinrich, N Mielenz, S Reese, A Steiner, A Starke
BACKGROUND: Local circulatory disturbances have been implicated in the development of foot disorders in cattle. The goals of this study were to evaluate the suitability of the interdigital artery in the pastern region in both hind limbs using pulsed-wave (PW) Doppler ultrasonography and to investigate quantitative arterial blood flow variables at that site in dairy cows. An Esaote MyLabOne ultrasound machine with a 10-MHz linear transducer was used to assess blood flow in the interdigital artery in the pastern region in both hind limbs of 22 healthy German Holstein cows...
June 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28577964/rp5063-a-novel-multimodal-serotonin-receptor-modulator-prevents-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats
#3
Laxminarayan Bhat, Jon Hawkinson, Marc Cantillon, Dasharatha G Reddy, Seema R Bhat, Charles E Laurent, Annie Bouchard, Marzena Biernat, Dany Salvail
Pulmonary arterial hypertension (PAH), a condition characterized by pulmonary vasculature constriction and remodeling, involves dysregulation of the serotonin (5-HT) receptors 5-HT2A and 5-HT2B. A rat model of monocrotaline (MCT)-induced PAH was used to examine the potential beneficial effects of RP5063, a 5-HT receptor modulator. After a single 60mg/kg dose of MCT, rats were gavaged twice-daily (b.i.d.) with vehicle, RP5063 (1, 3, or 10mg/kg), or sildenafil (50mg/kg) for 28 days. RP5063 at a dose as low as 1mg/kg, b...
May 31, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28577226/pet-measurements-of-myocardial-blood-flow-post-myocardial-infarction-relationship-to-invasive-and-cardiac-magnetic-resonance-studies-and-potential-clinical-applications
#4
Henry Gewirtz
This review focuses on clinical studies concerning assessment of coronary microvascular and conduit vessel function primarily in the context of acute and sub acute myocardial infarction (MI). The ability of quantitative PET measurements of myocardial blood flow (MBF) to delineate underlying pathophysiology and assist in clinical decision making in this setting is discussed. Likewise, considered are physiological metrics fractional flow reserve, coronary flow reserve, index of microvascular resistance (FFR, CFR, IMR) obtained from invasive studies performed in the cardiac catheterization laboratory, typically at the time of PCI for MI...
June 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28537863/severe-pellagra-masked-by-concurrent-plaque-psoriasis-a-case-report-of-a-hidden-diagnosis
#5
Elizabeth A Wang, Jason Kao, Michelle Y Cheng, Chelsea Ma, Soneet Dhillon, Thomas Konia, Emanual Maverakis, Cindy J Chambers
Despite characteristic features, psoriasis can mimic other dermatologic conditions, such as seborrheic dermatitis, lichen simplex chronicus, and certain nutritional deficiencies such as pellagra. We present a patient with a longstanding history of severe plaque psoriasis who presented with disfiguring scaly plaques involving greater than 80% body surface area. The patient's disease was minimally responsive to multiple therapies. Repeat punch biopsies demonstrated parakeratosis, psoriasiform hyperplasia, and dilated blood vessels consistent with psoriasis...
May 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28531788/association-of-dietary-factors-with-severity-of-coronary-artery-disease
#6
Namita Mahalle, M K Garg, S S Naik, M V Kulkarni
BACKGROUND: Cardiovascular disease has taken epidemic proportions during past decades. Cardiovascular risk factors contribute to progression of coronary lesions, worsening the patient's prognosis. This study was planned to analyze the association of dietary factors with severity of coronary artery disease (CAD) in Indian patients. METHODS: Three hundred patients with known coronary disease above the age of 25 years were included in this study. Blood samples were collected for biochemical markers...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28526406/trastuzumab-emtansine-suppresses-the-growth-of-her2-positive-small-cell-lung-cancer-in-preclinical-models
#7
Osamu Morimura, Toshiyuki Minami, Takashi Kijima, Shohei Koyama, Tomoyuki Otsuka, Yuhei Kinehara, Akio Osa, Masayoshi Higashiguchi, Kotaro Miyake, Izumi Nagatomo, Haruhiko Hirata, Kota Iwahori, Takayuki Takimoto, Yoshito Takeda, Hiroshi Kida, Atsushi Kumanogoh
Overcoming chemoresistance is essential for achieving better prognoses in SCLC. Previously, we reported that HER2 is upregulated when HER2-positive SCLC cells acquire chemoresistance. HER2-upregulated cisplatin- or etoposide-resistant SCLC cells were sensitive to trastuzumab-mediated ADCC. However, irinotecan-resistant SCLC cells, such as SBC-3/SN-38, were refractory to trastuzumab despite high HER2 expression. To address this issue, we examined the antitumor efficacy of trastuzumab emtansine (T-DM1) on trastuzumab-resistant HER2-positive SCLC...
May 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28525354/the-relationship-between-insulin-resistance-and-endothelial-dysfunction-in-obese-adolescents
#8
Preneet Cheema Brar, Payal Patel, Stuart Katz
BACKGROUND: Insulin resistance and endothelial dysfunction share a reciprocal relationship that links the metabolic and cardiovascular sequelae of obesity. We characterized the brachial artery reactivity testing (BART) and carotid artery-intima media thickness (CIMT) in adolescents categorized as obese insulin resistant (OIR) and obese not insulin resistant (ONIR). Lipoprotein particle (p) analysis and inflammatory cytokines in OIR and ONIR groups were also analyzed. METHODS: Obese adolescents (n=40; mean body mass index [BMI] 35...
May 24, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28511778/elevated-cranial-ultrasound-resistive-indices-are-associated-with-improved-neurodevelopmental-outcomes-one-year-after-pediatric-cardiac-surgery-a-single-center-pilot-study
#9
Christopher L Jenks, Ana Hernandez, Peter L Stavinoha, Michael C Morris, Fenghua Tian, Hanli Liu, Parvesh Garg, Joseph M Forbess, Joshua Koch
OBJECTIVE: To determine if a non-invasive, repeatable test can be used to predict neurodevelopmental outcomes in patients with congenital heart disease. METHODS: This was a prospective study of pediatric patients less than two months of age undergoing congenital heart surgery at the Children's Health Children's Medical Center at Dallas. Multichannel near-infrared spectroscopy (NIRS) was utilized during the surgery, and ultrasound (US) resistive indices (RI) of the major cranial vessels were obtained prior to surgery, immediately post-operatively, and prior to discharge...
May 13, 2017: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/28505975/reduced-cardiovascular-functions-in%C3%A2-patients-with-alzheimer-s-disease
#10
Wang-Sheng Jin, Xian-Le Bu, Ye-Ran Wang, Ling Li, Wei-Wei Li, Yu-Hui Liu, Chi Zhu, Xiu-Qing Yao, Yang Chen, Chang-Yue Gao, Tao Zhang, Hua-Dong Zhou, Fan Zeng, Yan-Jiang Wang
Previous studies have suggested that cardiovascular functions might play a critical role in Alzheimer's disease (AD) pathogenesis. However, the relationship among heart function, blood flow of cerebral vessels, and AD remains unclear. In the present study, AD patients (n = 34) and age- and gender-matched cognitively normal controls (n = 34) were recruited. Demographic and comorbidity information was collected. The ejection fraction was measured using echocardiography, and the mean velocity, pulsatility index (PI), and resistance index (RI) of the basilar artery (BA), left terminal internal carotid artery (LTICA), and right terminal internal carotid artery (RTICA) were measured using transcranial Doppler...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28485281/influence-of-the-amount-of-myocardium-subtended-to-a-coronary-stenosis-on-the-index-of-microcirculatory-resistance-implications-for-the-invasive-assessment-of-microcirculatory-function-in-ischemic-heart-disease
#11
Mauro Echavarría-Pinto, Tim P van de Hoef, Sukhjinder Nijjer, Nieves Gonzalo, Luis Nombela-Franco, Borja Ibañez, Sayan Sen, Ricardo Petraco, Pilar Jimenez-Quevedo, Ivan J Nuñez-Gil, Enrico Cerrato, Pablo Salinas, Alicia Quirós, Hector M Garcia-Garcia, Antonio Fernandez-Ortiz, Carlos Macaya, Justin Davies, Jan Piek, Javier Escaned
AIMS: The index of microcirculatory resistance (IMR) is growingly used to quantify microcirculatory function. However, in normal coronary arteries, resistance increases with the branching structure of the coronary tree, which suggest that IMR could be influenced by the amount of downstream myocardial mass (MM). We aimed to evaluate the influence of the amount of MM subtended to an intermediate stenosis on the IMR. METHODS AND RESULTS: IMR, fractional flow reserve and coronary flow reserve (CFR) were measured in 123 coronary arteries (102 patients) with intermediate stenosis...
May 9, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28461816/a-review-of-plant-based-compounds-and-medicinal-plants-effective-on-atherosclerosis
#12
REVIEW
Mehrnoosh Sedighi, Mahmoud Bahmani, Sedigheh Asgary, Fatemeh Beyranvand, Mahmoud Rafieian-Kopaei
Atherosclerosis is one of the most important cardiovascular diseases that involve vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis through affecting the involved factors. The main purpose of this review article is to investigate and introduce medicinal plants and their potential activities regarding antioxidant properties, effective on lipids level and development of plaque, atherosclerosis, and progression of atherosclerosis as well as the development of cardiovascular disease and ischemia...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28454806/assessing-micro-vascular-resistances-via-imr-to-predict-outcome-in-stemi-patients-with-multivessel-disease-undergoing-primary-pci-amicro-rationale-and-design-of-a-prospective-multicenter-clinical-trial
#13
Massimo Fineschi, Edoardo Verna, Giuseppe Mezzapelle, Davide Bartolini, Giovanni Turiano, Antonio Manari, Katia Lucarelli, Lucia Uguccioni, Alessandra Repetto, Giuseppe Tarantini
BACKGROUND: In STEMI patients treated with primary percutaneous coronary angioplasty (PPCI) the evaluation of coronary microcirculatory resistance index (IMR) predict the extent of microvascular damage and left ventricular (LV) remodeling. However, the impact of IMR on the clinical outcome after PPCI in patients with multivessel disease (MVD) remains unsettled. AIM: We designed a prospective multicenter controlled clinical trial to evaluate the prognostic value of IMR in terms of clinical outcome and left ventricular remodeling in STEMI patients with MVD undergoing PPCI...
May 2017: American Heart Journal
https://www.readbyqxmd.com/read/28367084/interrelationship-between-insulin-resistance-and-portal-haemodynamic-abnormality-in-cirrhosis
#14
Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Osamu Yokosuka
Background: There are only limited data regarding the effect of impaired portal circulation on the glucose metabolism. The study prospectively examined the interrelationship between insulin resistance (IR) and portal haemodynamic abnormality in cirrhosis. Methods: There were 53 cirrhosis patients (61.6 ± 13.0 years) all presenting gastroesophageal varices. Portal haemodynamics by both hepatic venous catheterisation and Doppler ultrasound were examined with respect to the homeostasis model assessment (HOMA)-IR and HOMA2-IR...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28315648/morphologic-and-doppler-findings-from-hepatic-ultrasonography-of-normal-cynomolgus-monkeys-macaca-fascicularis
#15
Kyo Won Lee, Chan Woo Cho, Ji Eun Lee, Hyojun Park, Gyu-Seong Choi, Woo Kyoung Jeong, Jae Berm Park, Sungjoo Kim
The present study evaluated the anatomic and ultrasonographic features of the liver in normal cynomolgus monkeys (Macaca fascicularis). Healthy, male, cynomolgus monkeys from Cambodia (n = 25; mean age, 58.1 mo) were sedated with ketamine (7 mg/kg) and examined by using 2D and Doppler ultrasonography. We measured the diameters of the vascular structures and bile duct, determined the velocities of the hepatic artery and portal vein, and calculated the resistance index of the hepatic artery. Vessel diameters were: proper hepatic artery, 1...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28294194/phosphodiesterase-5-inhibition-preserves-renal-hemodynamics-and-function-in-mice-with-diabetic-kidney-disease-by-modulating-mir-22-and-bmp7
#16
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M Isidori, Mary Anna Venneri
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P < 0.001), the increase of urine albumin creatinine ratio (P < 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28257508/longitudinal-changes-of-ocular-blood-flow-using-laser-speckle-flowgraphy-during-normal-pregnancy
#17
Takahiro Sato, Junichi Sugawara, Naoko Aizawa, Noriyuki Iwama, Fumiaki Takahashi, Michiyo Nakamura-Kurakata, Masatoshi Saito, Takashi Sugiyama, Hiroshi Kunikata, Toru Nakazawa, Nobuo Yaegashi
PURPOSE: Innovative laser speckle flowgraphy (LSFG) enables noninvasive evaluation of retinal microcirculation and the usefulness has been reported in the field of ophthalmology. LSFG has allowed us to measure the real time changes of retinal blood flow without pupillary dilatations and contrast media. Herein, we investigated the change of retinal blood flow in normal pregnant women during gestation using LSFG. METHODS: A prospective cohort study was conducted in 53 pregnant women who visited our institution between January, 2013 and July, 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28211310/morphologic-and-doppler-findings-from-hepatic-ultrasonography-of-normal-cynomolgus-monkeys-macaca-fascicularis
#18
Kyo Won Lee Chan Woo Cho Ji Eun Lee Hyojun Park Gyu-Seong Choi Woo Kyoung Jeong Jae Berm Park And Sungjoo Kim
The present study evaluated the anatomic and ultrasonographic features of the liver in normal cynomolgus monkeys (Macacafascicularis). Healthy, male, cynomolgus monkeys from Cambodia (n = 25; mean age, 58.1 mo) were sedated with ketamine (7mg/kg) and examined by using 2D and Doppler ultrasonography. We measured the diameters of the vascular structures and bile duct, determined the velocities of the hepatic artery and portal vein, and calculated the resistance index of the hepatic artery. Vessel diameters were: proper hepatic artery, 1...
February 16, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28164013/stenotic-flow-reserve-derived-from-quantitative-coronary-angiography-has-modest-but-incremental-value-in-predicting-functionally-significant-coronary-stenosis-as-evaluated-by-fractional-flow-reserve
#19
Elizabeth L Potter, Colin Machado, Yuvaraj Malaiapan, Om Narayan, Brian S H Ko, Peter J Psaltis, Kiran Munnur, James D Cameron, Ian T Meredith, Dennis Thiam Leong Wong
BACKGROUND: Stenotic flow reserve (SFR) derived from quantitative coronary angiography (QCA) has been correlated with myocardial ischaemia as determined by pharmacological stress echocardiography. However, the diagnostic accuracy of SFR in predicting functionally significant coronary stenosis as assessed by the gold standard, fractional flow reserve (FFR), has not been previously characterised. METHODS: Patients who underwent coronary angiography and FFR assessment between January 2010 and February 2012 in a single tertiary centre were retrospectively assessed...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28150225/altered-oscillation-of-doppler-derived-renal-and-renal-interlobar-venous-flow-velocities-in-hypertensive-and-diabetic-patients
#20
Yusuke Kudo, Taisei Mikami, Mutsumi Nishida, Kazunori Okada, Sanae Kaga, Nobuo Masauzi, Satomi Omotehara, Hitoshi Shibuya, Kaoru Kahata, Chikara Shimizu
BACKGROUND AND PURPOSE: Flow velocity oscillation rate (FVOR) of the renal interlobar vein has been reported to be decreased in patients with urinary obstruction or diabetic nephropathy, and increased in those with hypertension during pregnancy. To clarify the clinical role of the renal interlobar venous FVOR, we investigated the flow velocity patterns of the renal vessels in patients with hypertension (HT) and/or diabetes (DM). METHODS AND RESULTS: Pulsed-wave Doppler sonography was performed in 34 patients: 15 with HT, 10 with DM, and nine with both HT and DM (HT-DM)...
February 1, 2017: Journal of Medical Ultrasonics
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