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https://www.readbyqxmd.com/read/28367084/interrelationship-between-insulin-resistance-and-portal-haemodynamic-abnormality-in-cirrhosis
#1
Hitoshi Maruyama, Kazufumi Kobayashi, Soichiro Kiyono, Osamu Yokosuka
Background: There are only limited data regarding the effect of impaired portal circulation on the glucose metabolism. The study prospectively examined the interrelationship between insulin resistance (IR) and portal haemodynamic abnormality in cirrhosis. Methods: There were 53 cirrhosis patients (61.6 ± 13.0 years) all presenting gastroesophageal varices. Portal haemodynamics by both hepatic venous catheterisation and Doppler ultrasound were examined with respect to the homeostasis model assessment (HOMA)-IR and HOMA2-IR...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28315648/morphologic-and-doppler-findings-from-hepatic-ultrasonography-of-normal-cynomolgus-monkeys-macaca-fascicularis
#2
Kyo Won Lee, Chan Woo Cho, Ji Eun Lee, Hyojun Park, Gyu-Seong Choi, Woo Kyoung Jeong, Jae Berm Park, Sungjoo Kim
The present study evaluated the anatomic and ultrasonographic features of the liver in normal cynomolgus monkeys (Macaca fascicularis). Healthy, male, cynomolgus monkeys from Cambodia (n = 25; mean age, 58.1 mo) were sedated with ketamine (7 mg/kg) and examined by using 2D and Doppler ultrasonography. We measured the diameters of the vascular structures and bile duct, determined the velocities of the hepatic artery and portal vein, and calculated the resistance index of the hepatic artery. Vessel diameters were: proper hepatic artery, 1...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28294194/phosphodiesterase-5-inhibition-preserves-renal-hemodynamics-and-function-in-mice-with-diabetic-kidney-disease-by-modulating-mir-22-and-bmp7
#3
Riccardo Pofi, Daniela Fiore, Rita De Gaetano, Giuseppe Panio, Daniele Gianfrilli, Carlotta Pozza, Federica Barbagallo, Yang Kevin Xiang, Konstantinos Giannakakis, Susanna Morano, Andrea Lenzi, Fabio Naro, Andrea M Isidori, Mary Anna Venneri
Diabetic Nephropathy (DN) is the leading cause of end-stage renal disease. Preclinical and experimental studies show that PDE5 inhibitors (PDE5is) exert protective effects in DN improving perivascular inflammation. Using a mouse model of diabetic kidney injury we investigated the protective proprieties of PDE5is on renal hemodynamics and the molecular mechanisms involved. PDE5i treatment prevented the development of DN-related hypertension (P < 0.001), the increase of urine albumin creatinine ratio (P < 0...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28257508/longitudinal-changes-of-ocular-blood-flow-using-laser-speckle-flowgraphy-during-normal-pregnancy
#4
Takahiro Sato, Junichi Sugawara, Naoko Aizawa, Noriyuki Iwama, Fumiaki Takahashi, Michiyo Nakamura-Kurakata, Masatoshi Saito, Takashi Sugiyama, Hiroshi Kunikata, Toru Nakazawa, Nobuo Yaegashi
PURPOSE: Innovative laser speckle flowgraphy (LSFG) enables noninvasive evaluation of retinal microcirculation and the usefulness has been reported in the field of ophthalmology. LSFG has allowed us to measure the real time changes of retinal blood flow without pupillary dilatations and contrast media. Herein, we investigated the change of retinal blood flow in normal pregnant women during gestation using LSFG. METHODS: A prospective cohort study was conducted in 53 pregnant women who visited our institution between January, 2013 and July, 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28211310/morphologic-and-doppler-findings-from-hepatic-ultrasonography-of-normal-cynomolgus-monkeys-macaca-fascicularis
#5
Kyo Won Lee Chan Woo Cho Ji Eun Lee Hyojun Park Gyu-Seong Choi Woo Kyoung Jeong Jae Berm Park And Sungjoo Kim
The present study evaluated the anatomic and ultrasonographic features of the liver in normal cynomolgus monkeys (Macacafascicularis). Healthy, male, cynomolgus monkeys from Cambodia (n = 25; mean age, 58.1 mo) were sedated with ketamine (7mg/kg) and examined by using 2D and Doppler ultrasonography. We measured the diameters of the vascular structures and bile duct, determined the velocities of the hepatic artery and portal vein, and calculated the resistance index of the hepatic artery. Vessel diameters were: proper hepatic artery, 1...
February 16, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28164013/stenotic-flow-reserve-derived-from-quantitative-coronary-angiography-has-modest-but-incremental-value-in-predicting-functionally-significant-coronary-stenosis-as-evaluated-by-fractional-flow-reserve
#6
Elizabeth L Potter, Colin Machado, Yuvaraj Malaiapan, Om Narayan, Brian S H Ko, Peter J Psaltis, Kiran Munnur, James D Cameron, Ian T Meredith, Dennis Thiam Leong Wong
BACKGROUND: Stenotic flow reserve (SFR) derived from quantitative coronary angiography (QCA) has been correlated with myocardial ischaemia as determined by pharmacological stress echocardiography. However, the diagnostic accuracy of SFR in predicting functionally significant coronary stenosis as assessed by the gold standard, fractional flow reserve (FFR), has not been previously characterised. METHODS: Patients who underwent coronary angiography and FFR assessment between January 2010 and February 2012 in a single tertiary centre were retrospectively assessed...
February 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28150225/altered-oscillation-of-doppler-derived-renal-and-renal-interlobar-venous-flow-velocities-in-hypertensive-and-diabetic-patients
#7
Yusuke Kudo, Taisei Mikami, Mutsumi Nishida, Kazunori Okada, Sanae Kaga, Nobuo Masauzi, Satomi Omotehara, Hitoshi Shibuya, Kaoru Kahata, Chikara Shimizu
BACKGROUND AND PURPOSE: Flow velocity oscillation rate (FVOR) of the renal interlobar vein has been reported to be decreased in patients with urinary obstruction or diabetic nephropathy, and increased in those with hypertension during pregnancy. To clarify the clinical role of the renal interlobar venous FVOR, we investigated the flow velocity patterns of the renal vessels in patients with hypertension (HT) and/or diabetes (DM). METHODS AND RESULTS: Pulsed-wave Doppler sonography was performed in 34 patients: 15 with HT, 10 with DM, and nine with both HT and DM (HT-DM)...
February 1, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28115510/abnormal-wave-reflections-and-left-ventricular-hypertrophy-late-after-coarctation-of-the-aorta-repair
#8
Michael A Quail, Rebekah Short, Bejal Pandya, Jennifer A Steeden, Abbas Khushnood, Andrew M Taylor, Patrick Segers, Vivek Muthurangu
Patients with repaired coarctation of the aorta are thought to have increased afterload due to abnormalities in vessel structure and function. We have developed a novel cardiovascular magnetic resonance protocol that allows assessment of central hemodynamics, including central aortic systolic blood pressure, resistance, total arterial compliance, pulse wave velocity, and wave reflections. The main study aims were to (1) characterize group differences in central aortic systolic blood pressure and peripheral systolic blood pressure, (2) comprehensively evaluate afterload (including wave reflections) in the 2 groups, and (3) identify possible biomarkers among covariates associated with elevated left ventricular mass (LVM)...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28114163/doppler-ultrasonography-of-the-central-retinal-vessels-in-children-with-brain-death
#9
Becky J Riggs, Joanna S Cohen, Bhavana Shivakumar, Carmelina Trimboli-Heidler, Jason T Patregnani, Marijean M Miller, Michael C Spaeder, Nathan P Dean
OBJECTIVE: The purpose of this observational study is to explore if bedside Doppler ultrasonography of the central retinal vessels has the potential to become an ancillary study to support the timely diagnosis of brain death in children. DESIGN: Seventeen-month prospective observational cohort. SETTING: Forty-four bed pediatric medical and surgical ICU in an academic teaching hospital. PATIENTS: All children 0-18 years old who were clinically evaluated for brain death at Children's National Health Systems were enrolled and followed until discharge or death...
March 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28068755/systematic-quantitation-of-histologic-patterns-shows-accuracy-in-reflecting-cirrhotic-remodeling
#10
Yan Wang, Wei Huang, Ruhua Li, Zhaoqiang Yun, Youfu Zhu, Jinlian Yang, Hailin Liu, Zhipeng Liu, Qianjin Feng, Jinlin Hou
BACKGROUND AND AIM: There still lacks a tool for precisely evaluating cirrhotic remodeling. Histologic distortion characterized in cirrhosis (i.e. cirrhotic patterns) has a validated pathophysiological meaning and the potential relevance to clinical complications. We aimed to establish a new tool for quantify the cirrhotic patterns and test it for reflecting the cirrhotic remodeling. METHODS: We designed a computerized algorithm (qCP) dedicated for the analysis of liver images acquired by second harmonic microscopy...
January 9, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28062999/relationship-between-increased-carotid-artery-stiffness-and-idiopathic-subjective-tinnitus
#11
C Bayraktar, S Taşolar
Tinnitus is defined as perception of sound with no external stimulus, and can separate into pulsatile and non-pulsatile types. Arterial stiffness is a parameter that can predict the cardiovascular event and associated with incidence of stroke. It has been shown that increased arterial stiffness may lead to microvascular damage in brain. Our aim was to assess the arterial stiffness of the carotid system in the development and severity of idiopathic subjective tinnitus. Forty subjective tinnitus patients and 40 age- and sex-matched controls were enrolled in the study...
January 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28043350/evaluation-of-changes-in-doppler-ultrasonography-indices-and-levels-of-maternal-serum-angiogenic-factors-throughout-pregnancy-in-ewes
#12
Özge Turna Yilmaz, Mehmet Can Gündüz, Gamze Evkuran Dal, Melih Uçmak, Zeynep Günay Uçmak, Esra Karaçam, Güven Kaşikçi, Mehmet Ragip Kiliçarslan
We evaluated the changes in the pulsatility index (PI) and resistance index (RI) of fetal and maternal vessels and maternal serum angiogenic factors throughout pregnancy in 20 Kivircik ewes. They were examined for pregnancy detection on Day 30 after mating. The PI and RI during the pregnancies were followed using Doppler ultrasonography (USG) of the uterine artery, umbilical artery, fetal aorta, and fetal vena cava. Doppler USG was performed every 15 days beginning from the 40th day after mating. Blood samples were collected every 15 days starting from the day of mating...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28036119/impact-of-physical-activity-on-cardiovascular-status-in-obesity
#13
Lars Lind, Axel C Carlsson, Agneta Siegbahn, Johan Sundström, Johan Ärnlöv
BACKGROUND: We have recently shown that being physically active (PA) counteracts, but not eliminates the increased risk of future cardiovascular disease in over-weight and obese subjects. To investigate this further, we studied the impact of being normal weight, overweight and obese on multiple markers of subclinical cardiovascular disease in relation to physical activity. MATERIALS AND METHODS: At age 70, 1016 subjects were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28027775/triterpene-derivatives-from-euphorbia-enhance-resistance-against-verticillium-wilt-of-tomato
#14
Amal Smaili, Noureddine Mazoir, Lalla Aicha Rifai, Tayeb Koussa, Kacem Makroum, El Mostafa Kabil, Ahmed Benharref, Mohamed Faize
Oxidation of α-euphorbol and 31-norlanostenol, two triterpenic compounds isolated from the latex of Euphorbia resinifera and Euphorbia officinarum respectively, yielded four products named 3β-tosyloxy-4α,14α-dimethyl-5α-cholesta-7,9-diene; 4α,14α-dimethyl-5α-cholesta-7,9-dien-3β-ol; 24-methylen-elemo-lanosta-8,24-dien-3-one and elemo-lanost-8-en-3,11,24-trione. They were evaluated for protection of tomato plants against Verticillium dahliae in a greenhouse. The four semisynthesized products were phytotoxic at higher concentrations as they completely inhibited tomato germination at 100 and 500 μg/ml...
March 2017: Phytochemistry
https://www.readbyqxmd.com/read/28007742/invasive-minimal-microvascular-resistance-is-a-new-index-to-assess-microcirculatory-function-independent-of-obstructive-coronary-artery-disease
#15
Guus A de Waard, Sukhjinder S Nijjer, Martijn A van Lavieren, Nina W van der Hoeven, Ricardo Petraco, Tim P van de Hoef, Mauro Echavarría-Pinto, Sayan Sen, Peter M van de Ven, Paul Knaapen, Javier Escaned, Jan J Piek, Justin E Davies, Niels van Royen
BACKGROUND: Coronary microcirculatory dysfunction portends a poor cardiovascular outcome. Invasive assessment of microcirculatory dysfunction by coronary flow reserve (CFR) and hyperemic microvascular resistance (HMR) is affected by coronary artery disease (CAD). In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. METHODS AND RESULTS: We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27998454/-study-on-correlation-between-retinal-vessel-morphology-or-ocular-hemodynamic-parameter-and-internal-carotid-artery-stenosis
#16
H Y Li, H Wang, X J Zhang, Y H Feng, Z C Wang, Y L Wang
Objective: To analyze the correlation between retinal vascular calibers, ocular blood flow parameters and internal carotid artery stenosis and to evaluate the effect of internal carotid artery stenosis on ocular blood vessels comprehensively. Methods: A retrospective case-control study. The clinical data of 141 patients who underwent head-and-neck computed tomography (CT) angiography examinations of the ICA were collected at Beijing Friendship Hospital, Capital Medical University from January 2014 to January 2016...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27993200/a-novel-mouse-model-of-high-flow-induced-pulmonary-hypertension-surgically-induced-by-right-pulmonary-artery-ligation
#17
Anchen Zhang, Hongfei Wang, Shengwei Wang, Xiaofan Huang, Ping Ye, Xinling Du, Jiahong Xia
BACKGROUND: This study sought to establish a new model of high-flow pulmonary hypertension (PH) in mice. This model may be useful for studies seeking to reduce the pulmonary vascular resistance and delay the development of PH caused by congenital heart disease. MATERIALS AND METHODS: The right pulmonary artery was ligated via a right posterolateral thoracotomy. Pulmonary hemodynamics was evaluated by right heart catheterization immediately after ligation and at 2, 4, 8, and 12 wk postoperatively...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27990593/is-the-unaffected-eye-really-unaffected-color-doppler-ultrasound-findings-in-unilaterally-active-central-serous-chorioretinopathy
#18
Iclal Erdem Toslak, Muhammet Kazim Erol, Devrim Toslak, Bulent Cekic, Mehtap Barc Ergun, Jennifer E Lim-Dunham
PURPOSE: To evaluate ocular hemodynamic changes using color Doppler ultrasonography imaging (CDI) with an emphasis on unaffected eyes of patients with central serous chorioretinopathy (CSC). METHODS: Twenty-seven patients with active CSC and 25 controls were analyzed using spectral domain-optical coherence tomography (SD-OCT) and CDI for choroidal imaging and evaluation of retrobulbar vessels, respectively. RESULTS: Resistive index (RI), pulsatility index (PI), and peak systolic velocity (PSV) of the ophthalmic artery (OA) and PSV, end-diastolic velocity (EDV), and mean velocity (Vmean) of the central retinal artery (CRA) in the patient group were less than those in the control group...
April 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27932897/effect-of-ovarian-endometrioma-on-uterine-and-ovarian-blood-flow-in-infertile-women
#19
Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27908671/effect-of-gnrh-and-hcg-on-progesterone-concentration-and-ovarian-and-luteal-blood-flow-in-diestrous-mares
#20
L F C Brito, J M Baldrighi, C A Wolf, O J Ginther
The objective of the present study was to investigate the effect of reproductive hormones (GnRH, hCG, LH and progesterone) on the regulation of corpus luteum (CL) and ovarian blood flow. Diestrous mares received a single treatment of saline, 100μg gonadorelin (GnRH), or 1500IU hCG 10days after ovulation. Plasma LH and progesterone concentrations, resistance index (RI) for ovarian artery blood-flow, and percentage of corpus luteum (CL) with color-Doppler signals of blood flow were determined immediately before treatment (hour 0) and at hours 0...
January 2017: Animal Reproduction Science
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