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https://www.readbyqxmd.com/read/28068755/systematic-quantitation-of-histologic-patterns-shows-accuracy-in-reflecting-cirrhotic-remodeling
#1
Yan Wang, Wei Huang, Ruhua Li, Zhaoqiang Yun, Youfu Zhu, Jinlian Yang, Hailin Liu, Zhipeng Liu, Qianjin Feng, Jinlin Hou
BACKGROUND AND AIM: There still lacks a tool for precisely evaluating cirrhotic remodeling. Histologic distortion characterized in cirrhosis (i.e. cirrhotic patterns) has a validated pathophysiological meaning and the potential relevance to clinical complications. We aimed to establish a new tool for quantify the cirrhotic patterns and test it for reflecting the cirrhotic remodeling. METHODS: We designed a computerized algorithm (qCP) dedicated for the analysis of liver images acquired by second harmonic microscopy...
January 9, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28062999/relationship-between-increased-carotid-artery-stiffness-and-idiopathic-subjective-tinnitus
#2
C Bayraktar, S Taşolar
Tinnitus is defined as perception of sound with no external stimulus, and can separate into pulsatile and non-pulsatile types. Arterial stiffness is a parameter that can predict the cardiovascular event and associated with incidence of stroke. It has been shown that increased arterial stiffness may lead to microvascular damage in brain. Our aim was to assess the arterial stiffness of the carotid system in the development and severity of idiopathic subjective tinnitus. Forty subjective tinnitus patients and 40 age- and sex-matched controls were enrolled in the study...
January 6, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28043350/evaluation-of-changes-in-doppler-ultrasonography-indices-and-levels-of-maternal-serum-angiogenic-factors-throughout-pregnancy-in-ewes
#3
Özge Turna Yilmaz, Mehmet Can Gündüz, Gamze Evkuran Dal, Melih Uçmak, Zeynep Günay Uçmak, Esra Karaçam, Güven Kaşikçi, Mehmet Ragip Kiliçarslan
We evaluated the changes in the pulsatility index (PI) and resistance index (RI) of fetal and maternal vessels and maternal serum angiogenic factors throughout pregnancy in 20 Kivircik ewes. They were examined for pregnancy detection on Day 30 after mating. The PI and RI during the pregnancies were followed using Doppler ultrasonography (USG) of the uterine artery, umbilical artery, fetal aorta, and fetal vena cava. Doppler USG was performed every 15 days beginning from the 40th day after mating. Blood samples were collected every 15 days starting from the day of mating...
February 2017: Theriogenology
https://www.readbyqxmd.com/read/28036119/impact-of-physical-activity-on-cardiovascular-status-in-obesity
#4
Lars Lin, Axel C Carlsson, Agneta Siegbahn, Johan Sundström, Johan Ärnlöv
BACKGROUND: We have recently shown that being physically active (PA) counteracts, but not eliminates the increased risk of future cardiovascular disease in over-weight and obese subjects. To investigate this further, we studied the impact of being normal weight, overweight and obese on multiple markers of subclinical cardiovascular disease in relation to physical activity. MATERIALS AND METHODS: At age 70, 1016 subjects were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28027775/triterpene-derivatives-from-euphorbia-enhance-resistance-against-verticillium-wilt-of-tomato
#5
Amal Smaili, Noureddine Mazoir, Lalla Aicha Rifai, Tayeb Koussa, Kacem Makroum, El Mostafa Kabil, Ahmed Benharref, Mohamed Faize
Oxidation of α-euphorbol and 31-norlanostenol, two triterpenic compounds isolated from the latex of Euphorbia resinifera and Euphorbia officinarum respectively, yielded four products named 3β-tosyloxy-4α,14α-dimethyl-5α-cholesta-7,9-diene; 4α,14α-dimethyl-5α-cholesta-7,9-dien-3β-ol; 24-methylen-elemo-lanosta-8,24-dien-3-one and elemo-lanost-8-en-3,11,24-trione. They were evaluated for protection of tomato plants against Verticillium dahliae in a greenhouse. The four semisynthesized products were phytotoxic at higher concentrations as they completely inhibited tomato germination at 100 and 500 μg/ml...
December 24, 2016: Phytochemistry
https://www.readbyqxmd.com/read/28007742/invasive-minimal-microvascular-resistance-is-a-new-index-to-assess-microcirculatory-function-independent-of-obstructive-coronary-artery-disease
#6
Guus A de Waard, Sukhjinder S Nijjer, Martijn A van Lavieren, Nina W van der Hoeven, Ricardo Petraco, Tim P van de Hoef, Mauro Echavarría-Pinto, Sayan Sen, Peter M van de Ven, Paul Knaapen, Javier Escaned, Jan J Piek, Justin E Davies, Niels van Royen
BACKGROUND: Coronary microcirculatory dysfunction portends a poor cardiovascular outcome. Invasive assessment of microcirculatory dysfunction by coronary flow reserve (CFR) and hyperemic microvascular resistance (HMR) is affected by coronary artery disease (CAD). In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. METHODS AND RESULTS: We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27998454/-study-on-correlation-between-retinal-vessel-morphology-or-ocular-hemodynamic-parameter-and-internal-carotid-artery-stenosis
#7
H Y Li, H Wang, X J Zhang, Y H Feng, Z C Wang, Y L Wang
Objective: To analyze the correlation between retinal vascular calibers, ocular blood flow parameters and internal carotid artery stenosis and to evaluate the effect of internal carotid artery stenosis on ocular blood vessels comprehensively. Methods: A retrospective case-control study. The clinical data of 141 patients who underwent head-and-neck computed tomography (CT) angiography examinations of the ICA were collected at Beijing Friendship Hospital, Capital Medical University from January 2014 to January 2016...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27993200/a-novel-mouse-model-of-high-flow-induced-pulmonary-hypertension-surgically-induced-by-right-pulmonary-artery-ligation
#8
Anchen Zhang, Hongfei Wang, Shengwei Wang, Xiaofan Huang, Ping Ye, Xinling Du, Jiahong Xia
BACKGROUND: This study sought to establish a new model of high-flow pulmonary hypertension (PH) in mice. This model may be useful for studies seeking to reduce the pulmonary vascular resistance and delay the development of PH caused by congenital heart disease. MATERIALS AND METHODS: The right pulmonary artery was ligated via a right posterolateral thoracotomy. Pulmonary hemodynamics was evaluated by right heart catheterization immediately after ligation and at 2, 4, 8, and 12 wk postoperatively...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27990593/is-the-unaffected-eye-really-unaffected-color-doppler-ultrasound-findings-in-unilaterally-active-central-serous-chorioretinopathy
#9
Iclal Erdem Toslak, Muhammet Kazim Erol, Devrim Toslak, Bulent Cekic, Mehtap Barc Ergun, Jennifer E Lim-Dunham
PURPOSE: To evaluate ocular hemodynamic changes using color Doppler ultrasonography imaging (CDI) with an emphasis on unaffected eyes of patients with central serous chorioretinopathy (CSC). METHODS: Twenty-seven patients with active CSC and 25 controls were analyzed using spectral domain-optical coherence tomography (SD-OCT) and CDI for choroidal imaging and evaluation of retrobulbar vessels, respectively. RESULTS: Resistive index (RI), pulsatility index (PI), and peak systolic velocity (PSV) of the ophthalmic artery (OA) and PSV, end-diastolic velocity (EDV), and mean velocity (Vmean) of the central retinal artery (CRA) in the patient group were less than those in the control group...
December 18, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27932897/effect-of-ovarian-endometrioma-on-uterine-and-ovarian-blood-flow-in-infertile-women
#10
Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27908671/effect-of-gnrh-and-hcg-on-progesterone-concentration-and-ovarian-and-luteal-blood-flow-in-diestrous-mares
#11
L F C Brito, J M Baldrighi, C A Wolf, O J Ginther
The objective of the present study was to investigate the effect of reproductive hormones (GnRH, hCG, LH and progesterone) on the regulation of corpus luteum (CL) and ovarian blood flow. Diestrous mares received a single treatment of saline, 100μg gonadorelin (GnRH), or 1500IU hCG 10days after ovulation. Plasma LH and progesterone concentrations, resistance index (RI) for ovarian artery blood-flow, and percentage of corpus luteum (CL) with color-Doppler signals of blood flow were determined immediately before treatment (hour 0) and at hours 0...
January 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/27879450/human-placental-arterial-distensibility-birth-weight-and-body-size-are-positively-related-to-fetal-homocysteine-concentration
#12
Stephen W D'Souza, Nita Solanky, Jane Guarino, Stuart Moat, Colin P Sibley, Michael Taggart, Jocelyn D Glazier
Methionine demethylation during metabolism generates homocysteine (Hcy) and its remethylation requires folate and cobalamin. Elevated Hcy concentrations are associated with vascular-related complications of pregnancy, including increased vascular stiffness, predictive of clinical vascular disease. Maternal and fetal total Hcy (tHcy) concentrations are positively related, yet the influence of Hcy on fetoplacental vascular function in normal pregnancy has not been examined. We hypothesized that Hcy alters fetoplacental vascular characteristics with influences on fetal growth outcomes...
November 21, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27790544/diagnostic-accuracy-of-b-mode-usg-and-doppler-scan-for-ovarian-lesions
#13
Mamta Goyal, Vinish Kumar Agarwal
INTRODUCTION: Ultrasonography (USG) is considered as the primary imaging modality for confirmation of ovarian mass and to differentiate them in to benign or malignant. AIM: The present study was conducted with the aim to evaluate accuracy of B- mode USG and Doppler scan (Colour Doppler + Spectral Doppler) for ovarian lesions. MATERIALS AND METHODS: The patients included in the study were from those referred with either palpable adnexal mass or incidentally detected adnexal masses...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27766047/microrna-in-atherothromobosis-is-it-useful-as-a-disease-marker
#14
Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi, Nobuyuki Ohte
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can become a serious complication of atherosclerosis leading to acute cardiovascular events such as myocardial infarction and stroke. Clinical applications to use this knowledge remain scarce. The plasma levels of vascular endothelium-enriched microRNA (miRNAs) in patients with atherosclerotic vascular disease could serve as a disease marker...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27763874/effects-of-body-position-on-exercise-capacity-and-pulmonary-vascular-pressure-flow-relationships
#15
Kevin Forton, Yoshiki Motoji, Gael Deboeck, Vitalie Faoro, Robert Naeije
There has been revival of in interest in exercise testing of the pulmonary circulation for the diagnosis of pulmonary vascular disease, but there still is uncertainty about body position and the most relevant measurements. Doppler echocardiography pulmonary hemodynamic measurements were performed at progressively increased workload in 26 healthy adult volunteers in supine, semi-recumbent and upright positions which were randomly assigned at 24 hours intervals. Mean pulmonary artery pressure (mPAP) was estimated from the maximum tricuspid regurgitation jet velocity...
October 7, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27754150/os-29-02-circadian-blood-pressure-profile-abnormalities-and-autonomic-dysfunction
#16
Oleg Mamontov, Mikhail Bogachev, Andrey Kozlenoc
OBJECTIVE: To assess the autonomic regulation in patients with various circadian blood pressure profile (CBPP) anomalies that persisted despite of combined antihypertensive therapy. DESIGN AND METHOD: We studied 114 hypertensives aged 56,8 ± 17,9 years receiving combined antihypertensive therapy divided into two groups, with adequate (n = 61) and inadequate (n = 53) CBPP. Groups were comparable in terms of age and number of drugs intake per day (2.8 ± 1...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27703060/quantitative-assessment-of-parent-vessel-and-distal-intracranial-hemodynamics-following-pipeline-flow-diversion
#17
Sophia F Shakur, Victor A Aletich, Sepideh Amin-Hanjani, Ahmed E Hussein, Fady T Charbel, Ali Alaraj
BACKGROUND: Pipeline embolization devices (PEDs) are commonly used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intraparenchymal hemorrhage. Although intra-aneurysmal hemodynamic changes have been studied, parent vessel and intracranial hemodynamics after PED use are unknown. We examine the impact of flow diversion on parent artery and distal intracranial hemodynamics. METHOD: Patients with internal carotid cerebral aneurysms treated with PED who had flow volume rate, flow velocities, pulsatility index, resistance index, Lindegaard ratio, and wall shear stress (WSS) obtained after treatment using quantitative magnetic resonance angiography were reviewed...
October 4, 2016: Interventional Neuroradiology
https://www.readbyqxmd.com/read/27698790/glioblastoma-multiforme-effect-of-hypoxia-and-hypoxia-inducible-factors-on-therapeutic-approaches
#18
Wen-Juan Huang, Wei-Wei Chen, Xia Zhang
Central nervous system-based cancers have a much higher mortality rate with the 2016 estimates at 6.4 for incidence and 4.3 for deaths per 100,000 individuals. Grade IV astrocytomas, known as glioblastomas are highly aggressive and show a high proliferation index, diffused infiltration, angiogenesis, microvascular proliferation and pleomorphic vessels, resistance to apoptosis, and pseudopalisading necrosis. Extensive hypoxic regions in glioblastomas contribute to the highly malignant phenotype of these tumors...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27688688/incidence-of-insulin-resistance-and-diabetes-in-patients-with-portosystemic-shunts-without-liver-dysfunction
#19
Ying Li, Gao Yang, Jinwei Qiang, Songqi Cai, Hao Zhou
OBJECTIVE: To investigate the incidence of insulin resistance (IR) and diabetes in patients with chronic hepatic schistosomiasis japonica (HSJ) and portosystemic shunts (PSS). METHODS: Pre- and post-contrasted computed tomography images obtained from patients with HSJ and control subjects were reviewed by two radiologists who identified and graded any shunting vessels. Anthropometric measurements, hepatic enzymes, lipid profile, blood levels of albumin, glucose, insulin and homeostasis model assessment (HOMA-2) index of all participants were also assessed...
September 29, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27685989/hemodynamics-in-coronary-arterial-tree-of-serial-stenoses
#20
Xi Chen, Yang Gao, Bin Lu, Xinwei Jia, Liang Zhong, Ghassan S Kassab, Wenchang Tan, Yunlong Huo
Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field...
2016: PloS One
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