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https://www.readbyqxmd.com/read/28239141/chronic-myeloid-leukemia-associated-hypercalcemia-a-case-report-and-literature-review
#1
David Toro-Tobón, Sarimar Agosto, Sara Ahmadi, Maureen Koops, Jan M Bruder
BACKGROUND Hypercalcemia associated with chronic myeloid leukemia (CML) is an ominous sign. Although rare, several cases have been reported and multiple pathophysiologic mechanisms have been independently proposed. We present a patient case and a literature review of the clinical presentation and mechanisms of CML-associated hypercalcemia. CASE REPORT A 58-year-old male with a past medical history of CML diagnosed six years earlier, presented to the emergency department with one week of acute confusion, disorientation, polyuria, and polydipsia...
February 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28238454/moving-toward-a-shared-process-the-impact-of-parent-experiences-on-perinatal-palliative-care
#2
Susan L Hasegawa, Jessica T Fry
Perinatal palliative care programs seek to support parents expecting a baby diagnosed with a serious medical condition. Clinicians have increasingly recognized the importance of parental perspectives on the medical care mothers and their fetuses and live-born children receive, especially regarding factors influencing individual choices and knowledge of the medical community. We describe, using literature on trisomy 13 and trisomy 18, how information shared between parents and providers can improve perinatal counseling and family support...
February 23, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28237697/heart-transplantation-in-adults-with-congenital-heart-disease
#3
REVIEW
Lucile Houyel, Ngoc-Tram To-Dumortier, Yannick Lepers, Jérôme Petit, Régine Roussin, Mohamed Ly, Emmanuel Lebret, Elie Fadel, Jürgen Hörer, Sébastien Hascoët
With the advances in congenital cardiac surgery and postoperative care, an increasing number of children with complex congenital heart disease now reach adulthood. There are already more adults than children living with a congenital heart defect, including patients with complex congenital heart defects. Among these adults with congenital heart disease, a significant number will develop ventricular dysfunction over time. Heart failure accounts for 26-42% of deaths in adults with congenital heart defects. Heart transplantation, or heart-lung transplantation in Eisenmenger syndrome, then becomes the ultimate therapeutic possibility for these patients...
February 22, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28237294/automatic-planning-on-hippocampal-avoidance-whole-brain-radiotherapy
#4
Shuo Wang, Dandan Zheng, Chi Zhang, Rongtao Ma, Nathan R Bennion, Yu Lei, Xiaofeng Zhu, Charles A Enke, Sumin Zhou
Mounting evidence suggests that radiation-induced damage to the hippocampus plays a role in neurocognitive decline for patients receiving whole-brain radiotherapy (WBRT). Hippocampal avoidance whole-brain radiotherapy (HA-WBRT) has been proposed to reduce the putative neurocognitive deficits by limiting the dose to the hippocampus. However, urgency of palliation for patients as well as the complexities of the treatment planning may be barriers to protocol enrollment to accumulate further clinical evidence. This warrants expedited quality planning of HA-WBRT...
April 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28237193/evaluating-frameworks-that-provide-value-measures-for-health-care-interventions
#5
Jeanne S Mandelblatt, Scott D Ramsey, Tracy A Lieu, Charles E Phelps
The recent acceleration of scientific discovery has led to greater choices in health care. New technologies, diagnostic tests, and pharmaceuticals have widely varying impact on patients and populations in terms of benefits, toxicities, and costs, stimulating a resurgence of interest in the creation of frameworks intended to measure value in health. Many of these are offered by providers and/or advocacy organizations with expertise and interest in specific diseases (e.g., cancer and heart disease). To help assess the utility of and the potential biases embedded in these frameworks, we created an evaluation taxonomy with seven basic components: 1) define the purpose; 2) detail the conceptual approach, including perspectives, methods for obtaining preferences of decision makers (e...
February 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28236771/looking-back-and-to-the-future-%C3%A2-are-we-improving-cure-in-non-small-cell-lung-cancer
#6
David Walder, Mary O'Brien
In surgical series, cancer-free survival at 5 years is often referred to as a cure. In recent years, attempts to improve cure rates in non-small cell lung cancer (NSCLC) have focussed on earlier diagnosis through cost-effective screening programs. Systemic therapies have historically added only a small benefit to overall survival in both the adjuvant and palliative setting. However, in the last two decades, the development of new treatment options has added incremental improvements in NSCLC survival rates. Patients with a targetable sensitising mutation including epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase rearrangements have significantly better prognosis, and many will survive beyond 5 years...
February 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28236265/the-longitudinal-course-of-depression-symptomatology-following-a-palliative-rehabilitation-program
#7
Andrea Feldstain, Sophie Lebel, Martin R Chasen
PURPOSE: Patients with advanced cancer have increased life expectancy but suffer from ongoing burden. Depressive symptomatology is their most common mental health concern. The Ottawa Palliative Rehabilitation Program (PRP) offers rehabilitation for this population. It offers 8 weeks of individualized interdisciplinary rehabilitation, post cancer treatment. Interventions include medical (physician and nurse), physiotherapy, occupational therapy, dietary, and social work using a general self-efficacy framework...
February 24, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28236065/glioblastoma-spheroids-produce-infiltrative-gliomas-in-the-rat-brainstem
#8
Zhiping Zhou, Neal Luther, Ranjodh Singh, John A Boockvar, Mark M Souweidane, Jeffrey P Greenfield
PURPOSE: Diffuse intrinsic pontine glioma (DIPG) is universally fatal without proven therapy other than radiation therapy for palliation. Representative animal models will play an essential role in the preclinical stage of future therapy development. To address the shortage of representative models, we created a novel infiltrative brainstem glioma model in rats based on glioblastoma spheroids. METHODS: Cells dissociated from glioblastoma spheroids grown from surgical specimens were implanted into the brainstem of NIH nude rats...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28236016/fully-covered-stents-are-similar-to-semi-covered-stents-with-regard-to-migration-in-palliative-treatment-of-malignant-strictures-of-the-esophagus-and-gastric-cardia-results-of-a-randomized-controlled-trial
#9
Jan Persson, Ulrika Smedh, Åse Johnsson, Bo Ohlin, Magnus Sundbom, Magnus Nilsson, Lars Lundell, Berit Sund, Erik Johnsson
INTRODUCTION: Stent migration is a significant clinical problem in palliation of malignant strictures in the esophagus and gastro-esophageal junction (GEJ). We have compared a newer design of a fully-covered stent to a widely used semi-covered stent using migration >20 mm as the primary outcome variable. Effects on dysphagia, quality of life (QoL) and re-intervention frequency were also investigated. METHODS: Patients with dysphagia due to non-curable esophagus/GEJ cancer were randomized to receive either a more recent design of a fully-covered stent (n = 48) or a conventional semi-covered stent (n = 47)...
February 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28236011/the-controversial-role-of-electrochemotherapy-in-head-and-neck-cancer-a-systematic-review-of-the-literature
#10
REVIEW
Riccardo Lenzi, Luca Muscatello, Alberto Maria Saibene, Giovanni Felisati, Carlotta Pipolo
Electroporation, also known as electrochemotherapy, combines an antineoplastic agent with electroporation, causing localized progressive necrosis in the treated area. Today it is primarily used in the palliative treatment of cutaneous and subcutaneous metastases and has been found to be safe and efficacious in head and neck cancer recurrences. Despite the steady increase in the number of published studies this treatment is not universally available and used systematically in head and neck carcinomas. To shed light on its limitations and analyze treatment outcome we have, therefore, reviewed all available literature regarding this topic...
February 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28235727/acceptable-regret-model-in-the-end-of-life-setting-patients-require-high-level-of-certainty-before-forgoing-management-recommendations
#11
Athanasios Tsalatsanis, Iztok Hozo, Benjamin Djulbegovic
BACKGROUND: The acceptable regret model postulates that under some circumstances decision-makers may tolerate wrong decisions. The purpose of this work is to empirically evaluate the acceptable regret model of decision-making in the end-of-life care setting, where terminally ill patients consider seeking curative treatment versus accepting hospice/palliative care. METHODS: We conducted interviews with 48 terminally ill patients to assess their preferences about end-of-life treatment choices...
February 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28235223/-constipation-in-patients-with-incurable-cancer-recommendations-of-the-german-s3-guideline-palliative-medicine
#12
Stefan Wirz, Steffen T Simon, Thomas Frieling, Claudia Bausewein, Raymond Voltz, Anne Pralong, Stefan Mönig, Markus Follmann, Martin Holtmann, Gerhild Becker
No abstract text is available yet for this article.
February 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28235145/cardiac-transplantation-in-a-neonate-first-case-in-switzerland-and-european-overview
#13
Martin Schweiger, Brian Stiasny, F Immer, Christoph Bürki, M Schmiady, Hitendu Dave, Anna Cavigelli-Brunner, Oliver Kretschmar, Vincenzo Cannizzaro, Michael Hübler
Twenty-four percent of pediatric heart transplantations (pHTx) are carried out in infants. Neonatal heart transplantation is both rarely performed and challenging. We report on a newborn baby girl suffering from cardiac failure due to a huge tumor (24x52 mm) within the free wall of the left ventricle (LV) and subtotal obstruction of the main left bronchus. Following a surgical tumor resection, a Berlin Heart EXCOR left ventricular assist device was implanted as the bridge to the transplantation. In spite of an organ donor/recipient mismatch of >200%, both heart transplantation and the post-operative course were successful...
February 24, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28234799/detecting-synaptic-autoantibodies-in-psychoses-need-for-more-sensitive-methods
#14
Joseph C Masdeu
PURPOSE OF REVIEW: Schizophrenic psychosis affects near 1% of the population. It typically starts in the first three decades of life, leading most often to chronic disability: antipsychotic treatment is palliative, not curative. The neurobiological abnormalities underlying psychoses are likely to differ across patients, ranging from autosomal dominant genetic disease to substance abuse, but a decreased function of the N-methyl-D-aspartate (NMDA) receptor seems to be a common theme. Emerging evidence suggests that decreased NMDA receptor function may be caused by auto-antibodies against this receptor in some patients currently being diagnosed as having schizophrenia...
February 22, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28234165/does-surgical-bypass-or-palliative-resections-offer-the-better-palliative-treatment-for-advanced-pancreatic-cancer-a-meta-analysis
#15
Zhipeng Xu, Qinghui Fu, Xiaoqian Luo, Weina Lu
No abstract text is available yet for this article.
December 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28233535/meta-analysis-of-the-effectiveness-of-heart-transplantation-in-patients-with-a-failing-fontan
#16
Nazlee Tabarsi, Meijiao Guan, Jacob Simmonds, Mustafa Toma, Marla Kiess, Victor Tsang, Peter Ruygrok, Igor Konstantinov, William Shi, Jasmine Grewal
The Fontan procedure is increasingly being used to palliate univentricular physiology. It is a complex anatomic and physiologic repair that can fail at any age, often leaving heart transplantation as the only remaining solution. A meta-analysis was performed to achieve the aim of systematically evaluating the existing evidence for survival after heart transplantation in patients who have undergone a Fontan palliation. MEDLINE, Embase, PubMed, and Web of Science were searched for original research studies. The primary outcome was mortality at 1 and 5 years after transplantation...
January 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28233450/different-subtypes-of-epithelioid-sarcoma-and-their-clinical-implication-long-term-multi-institutional-experience-with-a-rare-sarcoma
#17
Chan Kim, Kwai Han Yoo, Min Hwan Kim, Hong Jae Chon, Soon Il Lee, Hyo Jin Lee, Sujin Koh, Ha Yeon Lee, Hye Ran Lee, Kyung Sik Kim, Young Deuk Choi, Sun Young Rha, Su Jin Lee, Hyo Song Kim
Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence...
March 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28232515/home-palliative-care-works-but-how-a-meta-ethnography-of-the-experiences-of-patients-and-family-caregivers
#18
REVIEW
Vera P Sarmento, Marjolein Gysels, Irene J Higginson, Barbara Gomes
OBJECTIVE: To understand patients and family caregivers' experiences with home palliative care services, in order to identify, explore and integrate the key components of care that shape the experiences of service users. METHODS: We performed a meta-ethnography of qualitative evidence following PRISMA recommendations for reporting systematic reviews. The studies were retrieved in 5 electronic databases (MEDLINE, EMBASE, PsycInfo, BNI, CINAHL) using 3 terms and its equivalents ('Palliative', 'Home care', 'Qualitative research') combined with 'AND', complemented with other search strategies...
February 23, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28232262/prevalence-predictors-and-outcomes-of-advance-directives-in-implantable-cardioverter-defibrillator-recipients
#19
Faisal M Merchant, Zachary Binney, Adarsh Patel, Jennifer Li, Lakshmi P Peddareddy, Mikhael F El-Chami, Angel R Leon, Tammie Quest
BACKGROUND: Little is known about advance directive (AD) utilization among implantable cardioverter defibrillator (ICD) recipients. OBJECTIVE: To define prevalence and predictors of ADs among patients with ICDs METHODS: We identified ICD recipients with ADs at our institution. The primary endpoint was the prevalence of an AD documented up to 1 year after device implant and the secondary endpoint was the cumulative prevalence of an AD. RESULTS: Out of 2,549 patients with ICDs, 701 were followed for at least one year after device implant and among them 164 (23...
February 20, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28231821/patient-centeredness-to-anticipate-and-organize-an-end-of-life-project-for-patients-receiving-at-home-palliative-care-a-phenomenological-study
#20
Agnès Oude Engberink, Mélanie Badin, Philippe Serayet, Sylvain Pavageau, François Lucas, Gérard Bourrel, Joanna Norton, Grégory Ninot, Pierre Senesse
BACKGROUND: The development of end-of-life primary care is a socio-medical and ethical challenge. However, general practitioners (GPs) face many difficulties when initiating appropriate discussion on proactive shared palliative care. Anticipating palliative care is increasingly important given the ageing population and is an aim shared by many countries. We aimed to examine how French GPs approached and provided at-home palliative care. We inquired about their strategy for delivering care, and the skills and resources they used to devise new care strategies...
February 23, 2017: BMC Family Practice
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