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https://www.readbyqxmd.com/read/29774469/higher-serum-levels-of-uric-acid-are-associated-with-a-reduced-insulin-clearance-in-non-diabetic-individuals
#1
Teresa Vanessa Fiorentino, Franz Sesti, Elena Succurro, Elisabetta Pedace, Francesco Andreozzi, Angela Sciacqua, Marta Letizia Hribal, Francesco Perticone, Giorgio Sesti
AIMS: Decreased insulin clearance has been reported to be associated with insulin resistance-related disorders and incident type 2 diabetes. The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. METHODS: 440 non-diabetic individuals were stratified in tertiles according to serum UA levels. Insulin clearance and skeletal muscle insulin sensitivity were assessed by euglycemic hyperinsulinemic clamp...
May 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29774465/effect-of-inositol-stereoisomers-at-different-dosages-in-gestational-diabetes-an-open-label-parallel-randomized-controlled-trial
#2
Federica Fraticelli, Claudio Celentano, Isaia Al Zecca, Giacoma Di Vieste, Basilio Pintaudi, Marco Liberati, Marica Franzago, Marta Di Nicola, Ester Vitacolonna
AIMS: Gestational diabetes mellitus (GDM) is the most common metabolic disorder of pregnancy. The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. METHODS: Participants were randomly allocated to receive daily: 400 mcg folic acid (control treatment), 4000 mg myo-inositol plus 400 mcg folic acid (MI treatment), 500 mg D-chiro-inositol plus 400 mcg folic acid (DCI treatment) or 1100/27...
May 17, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29774426/plant-physical-and-chemical-defence-variation-along-elevation-gradients-a-functional-trait-based-approach
#3
Alan Kergunteuil, Patrice Descombes, Gaetan Glauser, Loïc Pellissier, Sergio Rasmann
Predicting variation in plant functional traits related to anti-herbivore defences remains a major challenge in ecological research, considering that multiple traits have evolved in response to both abiotic and biotic conditions. Therefore, understanding variation in plant anti-herbivore defence traits requires studying their expression along steep environmental gradients, such as along elevation, where multiple biotic and abiotic factors co-vary. We expand on plant defence theory and propose a novel conceptual framework to address the sources of variations of plant resistance traits at the community level...
May 17, 2018: Oecologia
https://www.readbyqxmd.com/read/29774339/effects-of-oxygen-chemical-potential-on-the-anisotropy-of-the-adsorption-properties-of-zr-surfaces
#4
Hai-Hui Zhang, Yao-Ping Xie, Mei-Yi Yao, Jing-Xiang Xu, Jin-Long Zhang, Li-Juan Hu
The anisotropy of metal oxidation is a fundamental issue, and the oxidation of Zr surfaces also attracts much attention due to the application of Zr alloys as cladding materials for nuclear fuels in nuclear power plants. In this study, we systematically investigate the diagram of O adsorption on low Miller index Zr surfaces by using first-principles calculations based on density functional theory calculations. We find that O adsorption on the basal surface, Zr(0001), is more favourable than that on the prism surfaces, Zr(112[combining macron]0) and Zr(101[combining macron]0), under strong O-reducing conditions, while O adsorption on the prism surface is more favourable than that of the basal surface under weak O-reducing conditions and the O-rich conditions...
May 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29773450/acromioclavicular-joint-septic-arthritis-in-an-immunocompetent-child-a-case-report
#5
Saurabh Dutt, Jeetendra Lodhi, Vinod Kumar, Abhishek Kashyap
Septic arthritis of acromioclavicular (AC) joint is a rare entity. It is generally seen in patients who are immunocompromised. Only 15 cases have been reported till now, with only one case series of 6 patients. We report a case of septic arthritis of AC joint in an immunocompetent child. A 9 years old girl presented with history of pain in left shoulder for 4 days associated with fever. No history suggestive of any immunocompromised state was complained. On local examination, a swelling of around 3 cm in diameter was found over left AC joint region with raised local temperature, tenderness on palpation and positive response in fluctuation test...
March 23, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29772661/tensile-property-of-ansi-304-stainless-steel-weldments-subjected-to-cavitation-erosion-based-on-treatment-of-laser-shock-processing
#6
Lei Zhang, Yue-Hua Liu, Kai-Yu Luo, Yong-Kang Zhang, Yong Zhao, Jian-Yun Huang, Xu-Dong Wu, Chuang Zhou
Tensile property was one important index of mechanical properties of ANSI 304 stainless steel laser weldments subjected to cavitation erosion (CE). Laser shock processing (LSP) was utilized to strengthen the CE resistance, and the tensile property and fracture morphology were analyzed through three replicated experiment times. Results showed tensile process of treated weldments was composed of elastic deformation, plastic deformation, and fracture. The elastic limit, elastic modulus, elongation, area reduction, and ultimate tensile strength of tensile sample after CE were higher in view of LSP...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29772523/mhc-b-haplotypes-impact-susceptibility-and-resistance-to-rsv-a-infection
#7
Vishwa Mohini Khare, Vishesh Kumar Saxena, Alka Tomar, Karam Pal Singh, Kunwar Bahadur Singh, Amit Kumar Tiwari
We investigated the impact of haplotype of major histocompatibility complex (MHC)-B on the outcome of infection of Synthetic Dam Line (SDL) broiler strain with Rous Sarcoma Virus (RSV). Genomic analysis of MHC-B haplotypes, revealed a total of 12 known standard haplotypes that constituted to twenty-five different genotypes and one new haplotype of 217 bp size, designated BX . The inoculation of RSV-A in SDL chicks resulted in the development of tumors of progressive or regressive phenotypes with varying tumor profile index (TPI)...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29772102/novel-nomograms-for-castration-resistant-prostate-cancer-and-survival-outcome-in-patients-with-de-novo-bone-metastatic-prostate-cancer
#8
Jinge Zhao, Guangxi Sun, Banghua Liao, Xingming Zhang, Cameron M Armstrong, Xiaoxue Yin, Jiandong Liu, Junru Chen, Yaojing Yang, Peng Zhao, Qidun Tang, Zhenghao Wang, Zhibin Chen, Xiong Li, Qiang Wei, Xiang Li, Ni Chen, Allen C Gao, Pengfei Shen, Hao Zeng
OBJECTIVES: To develop nomograms predicting the incidence of castration resistant prostate cancer (CRPC) and overall survival (OS) for de novo metastatic prostate cancer (mPCa). MATERIALS AND METHODS: Data from 449 de novo mPCa patients were retrospectively analyzed. Patients were randomly divided into the training (n=314, 70%) and validation cohort (n=135, 30%). Predictive factors were selected by Cox-proportional model and further used for building predictive models...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29770339/red-blood-cell-distribution-width-is-associated-with-carotid-atherosclerosis-in-people-with-type-2-diabetes
#9
J S Nam, C W Ahn, S Kang, K R Kim, J S Park
Aims: Red cell distribution width (RDW) has been shown to be associated with cardiovascular diseases (CVD). The relationship between RDW and carotid intima-media thickness (C-IMT), a marker of subclinical atherosclerosis, has been inconsistent in subjects with cardiovascular risk factors. In this study, we investigated the relationship between RDW and carotid atherosclerosis in people with type 2 diabetes. Methods: Four hundred sixty-nine people with type 2 diabetes without history of cardiovascular or cerebrovascular diseases were enrolled...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29770124/does-family-history-of-obesity-cardiovascular-and-metabolic-diseases-influence-onset-and-severity-of-childhood-obesity
#10
Domenico Corica, Tommaso Aversa, Mariella Valenzise, Maria Francesca Messina, Angela Alibrandi, Filippo De Luca, Malgorzata Wasniewska
Objectives: The objectives were to evaluate (1) the metabolic profile and cardiometabolic risk in overweight/obese children at first assessment, stratifying patients according to severity of overweight and age; and (2) to investigate the relationship between family history (FH) for obesity and cardiometabolic diseases and severity of childhood obesity. Methods: In this cross-sectional, retrospective, observational study, 260 children (139 female), aged between 2...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29768966/mood-effects-of-blood-flow-restriction-resistance-exercise-among-basketball-players
#11
Júlio C G Silva, Rodrigo R Aniceto, Leandro S Oliota-Ribeiro, Gabriel R Neto, Leonardo S Leandro, Maria S Cirilo-Sousa
This study compared the acute effects of resistance exercise with and without blood flow restriction (BFR) on basketball players' mood states. A total of 11 male basketball players (mean age = 19.9, SD = 2.8 years; mean height = 180.8, SD = 7.8 cm; mean weight = 71.1, SD = 9.1 kg; mean body mass index = 22.1, SD = 1.9 kg/m2 ) were randomly assigned to two experimental conditions: (a) low-load resistance exercise with BFR (LLRE + BFR) and high-load resistance exercise (HLRE) without BFR...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29768720/bis-cyclic-guanidine-as-a-novel-class-of-compounds-potent-against-clostridium-difficile
#12
Chunhui Li, Peng Teng, Zhong Peng, Peng Sang, Xingmin Sun, Jianfeng Cai
Clostridium difficile infection (CDI) symptoms range from diarrhea to severe toxic megacolon and even death. Due to its rapid acquisition of resistance, C. difficile is listed as an urgent antibiotic-resistant threat, and has surpassed methicillin-resistant Staphylococcus aureus (MRSA) as the most common hospital-acquired infections in the USA. To combat the pathogen, the new structural class of pseudo peptides that exhibit antimicrobial activities could play an important role. Herein, we report that bis-cyclic guanidine compounds that exhibit potent antibacterial activity against C...
May 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29768692/prevalence-of-subclinical-hypothyroidism-in-obese-children-or-adolescents-and-association-between-thyroid-hormone-and-the-components-of-metabolic-syndrome
#13
Hye Young Jin
AIM: Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free thyroxine (fT4), and its clinical significance is unclear. The purpose of this study is to investigate the prevalence of subclinical hypothyroidism in children and adolescents and determine the relationship between lipid profiles, insulin resistance and thyroid hormones. METHODS: A retrospective, cross-sectional study was performed using data from a subset of the KNHANES VI...
May 16, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29768288/caffeine-sodium-benzoate-for-electroconvulsive-therapy-augmentation
#14
Kevin M Bozymski, Teresa G Potter, Vasu Venkatachalam, Ananda K Pandurangi, Ericka L Crouse
OBJECTIVES: Because of an ongoing manufacturer shortage of injectable caffeine sodium benzoate (CSB), patients at our health system were given CSB compounded in-house to increase seizure response during electroconvulsive therapy (ECT). Therefore, we aimed to evaluate its effectiveness and safety as an ECT augmentation agent. METHODS: Medical records of patients who received compounded CSB at Virginia Commonwealth University Health System were reviewed to identify adults receiving it as part of an index ECT treatment course between June 2012 and December 2016...
May 15, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29767680/propensity-for-adverse-pregnancy-outcomes-in-african-american-women-may-be-explained-by-low-energy-expenditure-in-early-pregnancy
#15
Jasper Most, L Anne Gilmore, Abby D Altazan, Marshall St Amant, Robbie A Beyl, Eric Ravussin, Leanne M Redman
Background: African-American (AA) women have poorer pregnancy outcomes and studies in nonpregnant women suggest a different etiology of weight gain in AA compared with white women. We hypothesized that physiologic factors such as low energy expenditure and physical activity would be present in AA compared with white women in pregnancy. Objective: We aimed to identify physiologic risk factors for disordered energy balance in AA and white women early in pregnancy...
May 14, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29767350/inverse-relationship-between-changes-of-maximal-aerobic-capacity-and-changes-in-walking-economy-after-weight-loss
#16
Juliano H Borges, Stephen J Carter, Harshvardhan Singh, Gary R Hunter
PURPOSE: The aims of this study were to: (1) determine the relationships between maximum oxygen uptake ([Formula: see text]O2max ) and walking economy during non-graded and graded walking among overweight women and (2) examine potential differences in [Formula: see text]O2max and walking economy before and after weight loss. METHODS: One-hundred and twenty-four premenopausal women with a body mass index (BMI) between 27 and 30 kg/m2 were randomly assigned to one of three groups: (a) diet only; (b) diet and aerobic exercise training; and (c) diet and resistance exercise training...
May 16, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29766465/effects-of-fenoldopam-on-renal-blood-flow-in-hypertensive-chronic-kidney-disease
#17
Valentina Rovella, Michele Ferrannini, Manfredi Tesauro, Giulia Marrone, Andrea Busca, Roberto Sorge, Simone Manca di Villahermosa, Maurizio Casasco, Nicola Di Daniele, Annalisa Noce
BACKGROUND AND AIM: The synthetic drug fenoldopam mesylate (FM) may have a renoprotective role, and a "renal dose" of 0.1 µg/kg/min intravenous (IV) infusion of FM has been reported as able to increase renal blood flow without affecting systemic blood pressure. But conclusive data are still lacking. We aimed to investigate by color-Doppler ultrasonography the effects of IV administration of FM at this dosage in hypertensive chronic kidney disease (CKD) patients, and verify whether it may induce any systemic hemodynamic alteration...
May 15, 2018: Journal of Nephrology
https://www.readbyqxmd.com/read/29766049/interleukin-1%C3%AE-deficient-mice-have-an-altered-gut-microbiota-leading-to-protection-from-dextran-sodium-sulfate-induced-colitis
#18
Moran Nunberg, Nir Werbner, Hadar Neuman, Marina Bersudsky, Alex Braiman, Moshe Ben-Shoshan, Meirav Ben Izhak, Yoram Louzoun, Ron N Apte, Elena Voronov, Omry Koren
Inflammatory bowel diseases (IBD) are a group of chronic inflammatory disorders of the intestine, with as-yet-unclear etiologies, affecting over a million people in the United States alone. With the emergence of microbiome research, numerous studies have shown a connection between shifts in the gut microbiota composition (dysbiosis) and patterns of IBD development. In a previous study, we showed that interleukin 1α (IL-1α) deficiency in IL-1α knockout (KO) mice results in moderate dextran sodium sulfate (DSS)-induced colitis compared to that of wild-type (WT) mice, characterized by reduced inflammation and complete healing, as shown by parameters of weight loss, disease activity index (DAI) score, histology, and cytokine expression...
May 2018: MSystems
https://www.readbyqxmd.com/read/29765813/isolation-and-characterization-of-fusarium-wilt-resistance-gene-analogs-in-radish
#19
Xiaona Yu, Dong Hyun Kang, Su Ryun Choi, Yinbo Ma, Lu Lu, Sang Heon Oh, Sushil Satish Chhapekar, Yong Pyo Lim
The resistance gene analog (RGA)-based marker strategy is an effective supplement for current marker reservoir of radish disease-resistance breeding. In this study, we identified RGAs based on the conserved nucleotide-binding site (NBS) and S-receptor-like kinase (SRLK) domains. A total of 68 NBS-RGAs and 46 SRLK-RGAs were isolated from two FW-resistant radish inbred lines, B2 and YR31, and one susceptible line, YR15. A BLASTx search revealed that the NBS-RGAs contained six conserved motifs (i.e., P loop, RNBS-A, Kinase-2, RNBS-B, RNBS-C, and GLPL) and the SRLK-RGAs, contained two conserved motifs (i...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29765510/correlation-between-metabolic-syndrome-and-sleep-apnea
#20
REVIEW
Alejandro Castaneda, Edgar Jauregui-Maldonado, Iqbal Ratnani, Joseph Varon, Salim Surani
The so-called "metabolic syndrome" (MS), constitutes a cluster of metabolic and cardiovascular abnormalities, including fasting glucose, blood pressure, triglycerides, high density lipoprotein cholesterol (HDL-C), and waist circumference that arise from insulin resistance. Obstructive sleep apnea (OSA) syndrome is characterized by recurrent episodes of partial or complete obstruction of the upper airway, involving cessation or significant decreased airflow, with intermittent hypoxemia, frequent arousals from sleep and recurrent oxyhemoglobin desaturations that interfere with normal sleep patterns generating difficulty falling asleep, unrefreshing sleep and loud snoring...
April 15, 2018: World Journal of Diabetes
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