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https://www.readbyqxmd.com/read/29352386/glucose-homeostasis-in-major-depression-and-schizophrenia-a-comparison-among-drug-na%C3%A3-ve-first-episode-patients
#1
Johann Steiner, Brisa S Fernandes, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Sabine Westphal, Katrin Borucki, Kolja Schiltz, Zoltán Sarnyai, Hans-Gert Bernstein
There is evidence for insulin resistance in drug-naïve first-episode schizophrenia (Sz) patients. We have tested whether impaired insulin homeostasis is also present in first-episode patients with major depression (MD) and if this can be discerned from stress-related and medication effects. Homeostatic model assessment of insulin resistance (HOMA-IR) was determined in a cross-sectional cohort study of acute first-episode drug-naïve patients with MD (n = 18) or Sz (n = 24), and healthy controls (C, n = 43)...
January 19, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29352359/unilateral-lichtenstein-tension-free-mesh-hernia-repair-and-testicular-perfusion-a-prospective-control-study
#2
J Aguilar-García, H A Cano-González, M A Martínez-Jiménez, F de la Rosa-Zapata, M Sánchez-Aguilar
PURPOSE: Compare testicular perfusion between the herniated and the healthy side pre- and post-surgery. MATERIALS AND METHODS: Our study was done on patients with unilateral inguinal hernia. A Doppler ultrasound study was performed in the healthy and herniated side before surgery and 3 months after it. RESULTS: 31 patients were included, 74.2% on the right and 25.8% on the left side. When comparing the pre-surgical values of testicular resistance index from the healthy side with those on the herniated side, there was a significant difference at the spermatic cord levels (0...
January 19, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29352146/effects-of-renal-denervation-on-cardiac-structural-and-functional-abnormalities-in-patients-with-resistant-hypertension-or-diastolic-dysfunction
#3
Shiying Wang, Suxia Yang, Xinxin Zhao, Jun Shi
The aim of the present study is to systematically evaluate the impact of RDN on cardiac structure and function in patients with resistant hypertension (RH) or diastolic dysfunction. We retrieved Pubmed, Embase and Cocharane Library databases, from inception to April 1st, 2016. Studies reporting left ventricular mass (LVMI) or left ventricular (LV) diastolic function (reflected by the ratio of mitral inflow velocity to annular relaxation velocity [E/e']) responses to RDN were included. Two randomized controlled trials (RCTs), 3 controlled studies and 11 uncontrolled studies were finally identified...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351564/steatosis-in-south-african-women-how-much-and-why
#4
Nitien H Naran, Mark Haagensen, Nigel J Crowther
BACKGROUND: Globally, steatosis is the commonest type of liver pathology and is closely associated with obesity and the metabolic syndrome. Obesity is common in urban African females but no data is available on hepatic fat content in this population group when compared to other ethnic groups. The aim of this study was therefore to compare hepatic fat content in woman from different ethnic groups in South Africa and to characterise the principle determinants of liver fat. MATERIALS AND METHODS: A convenience sample of 106 (48 Indian, 29 African and 29 Caucasian) female volunteers aged 20-60 years and having no history of cardiometabolic disorders were recruited...
2018: PloS One
https://www.readbyqxmd.com/read/29351481/regulation-of-glucose-metabolism-in-non-diabetic-metabolically-obese-normal-weight-asians
#5
Cherlyn Ding, Zhiling Chan, Yu Chung Chooi, John Choo, Suresh Anand Sadananthan, Amanda Chang, S Sasikala, Navin Michael, S Sendhil Velan, Faidon Magkos
Type 2 diabetes in Asia occurs largely in the absence of obesity. The metabolically-obese normal-weight (MONW) phenotype refers to lean subjects with metabolic dysfunction that is typically observed in people with obesity, and is associated with increased risk for diabetes. Previous studies evaluated MONW subjects who had greater BMI or total body fat than respective control groups, making interpretation of the results difficult. We evaluated insulin sensitivity (hyperinsulinemic-euglycemic clamp), insulin secretion (mixed meal with oral minimal modeling), intra-abdominal, muscle, and liver fat contents (magnetic resonance), and fasting and postprandial glucose and insulin concentrations in 18 MONW subjects and 18 metabolically-healthy controls matched for age (43{plus minus}3 and 40{plus minus}3 y; P=0...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351260/fatty-acid-based-microemulsions-to-combat-ophthalmia-neonatorum-caused-by-neisseria-gonorrhoeae-and-staphylococcus-aureus
#6
Ummara Butt, Amr ElShaer, Lori A S Snyder, Ali A Al-Kinani, Adam Le Gresley, Raid G Alany
The bacterial species Neisseria gonorrhoeae (N. gonorrhoeae) and Staphylococcus aureus (S. aureus) are amongst the main microorganisms that cause ophthalmia neonatorum. The current treatment involves the use of various antibiotics such as ciprofloxacin, cephalosporin, ceftriaxone and cefotaxime. However, this treatment strategy is becoming more ineffective due to the antibiotic resistance in N. gonorrhoeae. The current study explores the potential use of fatty acid based microemulsions (ME) to prevent N. gonorrhoeae and S...
January 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29350476/investigating-the-mechanisms-underlying-phytoprotection-by-plant-growth-promoting-rhizobacteria-in-spartina-densiflora-under-metal-stress
#7
K Paredes-Páliz, R Rodríguez-Vázquez, B Duarte, M A Caviedes, E Mateos-Naranjo, S Redondo-Gómez, Isabel Caçador, Ignacio D Rodríguez-Llorente, E Pajuelo
Pollution of coasts by toxic metals and metalloids is a worldwide problem for which phytoremediation using halophytes and associated microbiomes is getting relevance. Metal(loid)s excess is a constraint for plant establishment and development, and plant growth promoting rhizobacteria (PGPR) mitigate plant stress under these conditions. However, mechanisms underlying this effect remain elusive. In this paper, the effect of toxic metal(loid)s on the activity of ROS-scavenging enzymes in roots of the halophyte Spartina densiflora grown on real polluted sediments in a green house experiment, was investigated...
January 19, 2018: Plant Biology
https://www.readbyqxmd.com/read/29350442/role-of-ethylene-and-related-gene-expression-in-the-interaction-between-strawberry-plants-and-the-plant-growth-promoting-bacterium-azospirillum-brasilense
#8
J M Elías, M F Guerrero-Molina, M G Martínez-Zamora, J C Díaz-Ricci, R O Pedraza
• The induced systemic resistance (ISR) is one of the indirect mechanisms of growth promotion exerted by plant growth-promoting bacteria, and can be mediated by ethylene (ET). We assessed the ET production and the expression of related genes in the Azospirillum-strawberry plant interaction. • ET production was evaluated by gas chromatography in plants inoculated or not with A. brasilense REC3. Also, plants were treated with AgNO3 , an inhibitor of ET biosynthesis; with 1-aminocyclopropane-1-carboxylic-acid (ACC), a precursor of ET biosynthesis; and with indole acetic acid (IAA)...
January 19, 2018: Plant Biology
https://www.readbyqxmd.com/read/29350334/the-triglyceride-glucose-index-an-insulin-resistance-marker-in-newborns
#9
Eva Gesteiro, Sara Bastida, Laura Barrios, Francisco J Sánchez-Muniz
The study aims to assess the utility of the triglyceride-glucose index (TyG) as a marker of insulin resistance (IR) in neonates. TyG and the homeostatic model assessment (HOMA-IR) values were compared in 196 singleton, term normoweight and without distress newborns. A Decision Tree procedure (CHAID) was used to classify cases into groups or predict values of a dependent (Ln HOMA-IR) variable. Three nodes were drawn for TyG: ≤ 6.7, > 6.7-7.8 and > 7.8 (p < 0.0001; F = 20.52). The predictability of those TyG values vs HOMA-IR was statistically significant (p < 0...
January 19, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29349944/investigation-of-clinical-and-pathological-relationships-between-adult-and-pediatric-type-nash-in-korean-children
#10
Jungmin Yoon, Byung Han Park, Ja Hye Kim, Jin Hwa Moon, Young Ho Lee, Se Min Jang, Yong Joo Kim
BACKGROUND: Histologically, nonalcoholic steatohepatitis (NASH) is categorized into adult-type (type 1) and pediatric-type (type 2). The origination of the histological difference between the two types and how they differ clinically remain uncertain. We aimed to understand the incidence and clinical characteristics of the two types of NASH in Korean children, and to investigate the association between their pathological type and clinical characteristics, using anthropometric and laboratory data...
January 29, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29349498/plasma-metabolites-associated-with-type-2-diabetes-in-a-swedish-population-a-case-control-study-nested-in-a-prospective-cohort
#11
Lin Shi, Carl Brunius, Marko Lehtonen, Seppo Auriola, Ingvar A Bergdahl, Olov Rolandsson, Kati Hanhineva, Rikard Landberg
AIMS/HYPOTHESIS: The aims of the present work were to identify plasma metabolites that predict future type 2 diabetes, to investigate the changes in identified metabolites among individuals who later did or did not develop type 2 diabetes over time, and to assess the extent to which inclusion of predictive metabolites could improve risk prediction. METHODS: We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort...
January 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29348994/the-association-of-mediterranean-diet-and-exercise-modifications-with-anthropometric-parameters-in-a-psychiatric-community-population-a-pilot-study
#12
Rosaria Di Lorenzo, Jessica Pedretti, Letizia Grossi, Benedetta Cuoghi, Cinzia Varni, Giulia Landi, Ludovica Spattini, Chiara Visentini, Paola Ferri, Francesca Carubbi
Weight gain and related metabolic syndrome (MS) are major current issues in public health. MS consists of abdominal fat, atherogenic dyslipidemia, hypertension, hyperglycemia, insulin resistance, pro-inflammatory and pro-thrombotic state, and accounts for both cardiovascular diseases and type II diabetes mellitus risk factors. Patients affected by psychiatric illness present a prevalence of 35-40% of MS. Many studies have shown that Mediterranean diet is associated with the reduction of mortality due to cardiovascular and malignant diseases, potentially preventing both obesity and type II diabetes mellitus...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29348487/h1-phgfk1-nanoparticles-exert-anti-tumoural-and-radiosensitising-effects-by-inhibition-of-met-in-glioblastoma
#13
Wenyan Zhang, Rui Duan, Jian Zhang, William K C Cheung, Xiaoge Gao, Raymond Zhang, Qing Zhang, Mengxue Wei, Gang Wang, Qian Zhang, Peng-Jin Mei, Hong-Lin Chen, Hsiangfu Kung, Marie C Lin, Zan Shen, Junnian Zheng, Longzhen Zhang, Hong Yao
BACKGROUND: The therapeutic resistance to ionising radiation (IR) and anti-angiogenesis mainly impair the prognosis of patients with glioblastoma. The primary and secondary MET aberrant activation is one crucial factor for these resistances. The kringle 1 domain of hepatocyte growth factor (HGFK1), an angiogenic inhibitor, contains a high-affinity binding domain of MET; however, its effects on glioblastoma remain elusive. METHODS: We formed the nanoparticles consisting of a folate receptor-targeted nanoparticle-mediated HGFK1 gene (H1/pHGFK1) and studied its anti-tumoural and radiosensitive activities in both subcutaneous and orthotopic human glioma cell-xenografted mouse models...
January 18, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29348480/association-between-plasma-concentrations-of-branched-chain-amino-acids-and-adipokines-in-japanese-adults-without-diabetes
#14
Ryoko Katagiri, Atsushi Goto, Sanjeev Budhathoki, Taiki Yamaji, Hiroshi Yamamoto, Yumiko Kato, Motoki Iwasaki, Shoichiro Tsugane
Previous studies have consistently reported an association between circulating levels of branched-chain amino acids (BCAAs) or adipokines and insulin resistance; however, the association between BCAA and adipokine levels remains to be clarified. In this cross-sectional study involving 678 participants (435 men) without diabetes, plasma BCAA (valine, leucine, and isoleucine), adipokine (total and high molecular weight [HMW] adiponectin, leptin, and tumor necrosis factor-α [TNF-α]) concentrations, and an updated homeostasis model assessment of insulin resistance (HOMA2-IR) were measured...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347957/high-parasite-burden-increases-the-surfacing-and-mortality-of-the-manila-clam-ruditapes-philippinarum-in-intertidal-sandy-mudflats-on-the-west-coast-of-korea-during-hot-summer
#15
Ki-Woong Nam, Hee-Do Jeung, Jae-Hee Song, Kwan-Ha Park, Kwang-Sik Choi, Kyung-Il Park
BACKGROUND: Over the past few decades, mass mortality events of Manila clams have been reported from several tidal flats on the west coast of Korea during hot summers. During such mortality events, once clams simultaneously surface, they fail to re-burrow, perishing within a week. The present study aimed to identify the possible causes of the mass mortality of this clam species by investigating the Perkinsus olseni parasite burden and immune parameters of surfaced clams (SC) and normal buried clams (NBCs) when sea water or sediment temperature in the study area varied from 25 °C to 34 °C from late July through mid-August 2015...
January 18, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29346779/predictors-of-recoverability-of-renal-function-after-pyeloplasty-in-adults-with-ureteropelvic-junction-obstruction
#16
Xiao-Dong Li, Yu-Peng Wu, Yong Wei, Shao-Hao Chen, Qing-Shui Zheng, Hai Cai, Xue-Yi Xue, Ning Xu
BACKGROUND: This study aimed to identify factors predicting the recoverability of renal function after pyeloplasty in adult patients with ureteropelvic junction obstruction. METHODS: We retrospectively reviewed 138 adults with unilateral renal obstruction-induced hydronephrosis and who underwent Anderson-Hynes dismembered pyeloplasty from January 2013 to January 2016. Hydronephrosis was classified preoperatively according to the Society for Fetal Urology (SFU) grading system...
January 18, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29346609/decreased-serum-levels-of-ghrelin-and-brain-derived-neurotrophic-factor-in-premenopausal-women-with-metabolic-syndrome
#17
Masoumeh Jabbari, Sorayya Kheirouri, Mohammad Alizadeh
Objective: We aimed to investigate the association between serum levels of ghrelin and brain-derived neurotrophic factor (BDNF) with MetS and its components in premenopausal women. Methods: 43 patients with MetS and 43 healthy controls participated in this study. Participants' body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high density lipoprotein cholesterol (LDL-C and HDL-C), fasting blood sugar (FBS), insulin, BDNF and ghrelin determined...
January 12, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29344840/design-and-rationale-for-comparison-between-ticagrelor-and-clopidogrel-on-microcirculation-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention-pleio-trial
#18
Kyungil Park, Young-Rak Cho, Jong-Sung Park, Tae-Ho Park, Moo-Hyun Kim, Young-Dae Kim
It has been previously demonstrated that ticagrelor can reduce mortality compared to clopidogrel in acute coronary syndrome (ACS) patients. However, the mechanism for this mortality reduction remains uncertain. The objective of the present study is to assess the impact of chronic ticagrelor treatment on microvascular circulation. A total of 120 participants aged 20-85 years with clinical diagnosis of ACS will be randomized in a 1:1 fashion to the following two groups: ticagrelor 90 mg twice daily; clopidogrel 75 mg once daily...
January 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29344622/barriers-to-and-facilitators-of-implementing-enhanced-recovery-pathways-using-an-implementation-framework-a-systematic-review
#19
Alexander B Stone, Christina T Yuan, Michael A Rosen, Michael C Grant, Lauren E Benishek, Elizabeth Hanahan, Lisa H Lubomski, Clifford Ko, Elizabeth C Wick
Importance: Enhanced recovery pathways (ERPs) have the potential to reduce length of hospital stay, costs, and complications following surgery but can be challenging to implement. Objective: To examine the body of literature on ERPs to assess how authors describe barriers and facilitators of ERP implementation and identify, in aggregate, the best practices that should be considered utilizing the Consolidated Framework for Implementation Research (CFIR) to extract these elements and summarize common barriers and facilitators according to its 5 major domains: (1) intervention characteristics, (2) inner setting, (3) outer setting, (4) characteristics of the individuals, and (5) the process of implementation...
January 17, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29344030/optimal-cutoff-points-for-anthropometric-variables-to-predict-insulin-resistance-in-polycystic-ovary-syndrome
#20
Hossein Hatami, Seyed Ali Montazeri, Nazanin Hashemi, Fahimeh Ramezani Tehrani
Background: Insulin resistance (IR) is a major cardiometabolic risk factor in females with polycystic ovary syndrome (PCOS). The euglycemic clamp is the gold standard method to measure IR. However, considering the time and cost that it takes, surrogate markers of IR are now widely used. The current study aimed at evaluating the cutoff points of even less invasive anthropometric and body composition variables to predict IR in females with PCOS. Methods: The current cross sectional study selected 224 females with PCOS, using Rotterdam criteria, referred to reproductive endocrinology research center; 88 of which were diagnosed with insulin resistance...
October 2017: International Journal of Endocrinology and Metabolism
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