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https://www.readbyqxmd.com/read/29156685/whole-genome-and-transcriptome-analysis-reveal-maldi-tof-ms-and-sds-page-have-limited-performance-for-the-detection-of-the-key-outer-membrane-protein-in-carbapenem-resistant-klebsiella-pneumoniae-isolates
#1
Naina Adren Pinto, Roshan D'Souza, In Sik Hwang, Jongrak Choi, Yong Ha In, Hyung Soon Park, Choong-Min Ryu, Dongeun Yong, Kyungwon Lee
To detect the outer membrane protein (OMP), which plays a key role in carbapenem resistance, whole-genome and transcriptome analysis of the clinical carbapenem-resistant Klebsiella pneumoniae was carried out. The index strain lacked both OmpK35 and OmpK36, whereas the other strains lacked only OmpK35. After SDS-PAGE, the putative OMP bands were excised and identified as OmpA and OmpK36. MALDI-TOF MS showed peaks at ∼36 and ∼38 kDa that corresponded to OmpA and OmpK36, respectively. In all the strains except YMC2014/03/P345, the ∼38 kDa peaks were present...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155986/prenatal-high-estradiol-exposure-induces-sex-specific-and-dietarily-reversible-insulin-resistance-through-decreased-hypothalamic-insr
#2
Hui-Hui Wang, Cheng-Liang Zhou, Min Lv, Qian Yang, Ju-Xue Li, Min Hou, Jing Lin, Xin-Mei Liu, Yan-Ting Wu, Jian-Zhong Sheng, He-Feng Huang
Adverse intrauterine environment may induce adult disease in offspring, but the mechanisms are not well understood. It is reported that fresh embryo transfer (ET) in assisted reproductive technology presents extra-high maternal estradiol (E2) and prenatal high E2 exposure increases the risk of organ disorders in later life. We found male newborns and children of fresh ET showed increased fasting insulin and the homeostasis model of assessment for insulin resistance index (HOMA-IR). Prenatal high E2 exposed (HE) male mice grew heavier than control and developed insulin resistance, they also showed increased food intake with enhanced orexigenic hypothalamic neuropeptide Y (NPY) expression...
November 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/29155195/unreliability-of-the-duplex-scan-in-diagnosing-corporeal-venous-occlusive-disease-cvod-in-young-healthy-males-with-erectile-deficiency-ed
#3
Giorgio Cavallini, Carlo Maretti
OBJECTIVE: To define the role of cavernosal venous occlusive dysfunction (CVOD) as the only cause of erectile dysfunction (ED). MATERIALS AND METHODS: Patients meeting the CVOD criteria without any risk factors for organic ED were randomized into 2 groups; the end diastolic velocity (EDV), peak systolic velocity (PSV) and resistive index (RI) of their cavernosal arteries were assessed using color duplex Doppler ultrasound (CDDU) after intracavernous injection of Alprostadil 10 mcg (ICI)...
November 16, 2017: Urology
https://www.readbyqxmd.com/read/29154726/comparison-of-apolipoprotein-apob-apoa-1-and-lipoprotein-total-cholesterol-hdl-ratios-in-obese-adolescents
#4
Ramin Alemzadeh, Jessica Kichler
BACKGROUND: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. METHODS: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents...
November 20, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29154426/microvascular-dysfunction-and-cardiac-fibrosis-in-heart-failure-with-preserved-ejection-fraction-a-case-report
#5
Nikhil Narang, Diego Medvedofsky, Kathryn Dryer, Sanjiv J Shah, Charles J Davidson, Amit R Patel, John E A Blair
We report the case of a 55-year-old woman with heart failure with preserved ejection fraction (HFpEF), who presented with hypertensive urgency and pulmonary oedema. The patient was medically optimized and underwent cardiac catheterization revealing pulmonary hypertension, elevated pulmonary capillary wedge pressure, normal cardiac index, and non-obstructive coronary disease. Invasive evaluation of coronary flow revealed blunted coronary flow reserve and increased index of microvascular resistance. Cardiac magnetic resonance imaging demonstrated reduced global myocardial perfusion and diffuse interstitial fibrosis...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153939/serum-concentrations-of-fetuin-b-in-lipodystrophic-patients
#6
Konstanze Miehle, Thomas Ebert, Susan Kralisch, Annett Hoffmann, Jürgen Kratzsch, Haiko Schlögl, Michael Stumvoll, Mathias Fasshauer
OBJECTIVE: Fetuin B is an adipokine/hepatokine which is significantly elevated in insulin resistance/type 2 diabetes mellitus and hepatic steatosis. Regulation of fetuin B in patients with lipodystrophy (LD) - a disease group which is characterized by subcutaneous adipose tissue loss, hypertriglyceridemia, hepatic steatosis, insulin resistance, and dysregulation of several adipokines - has not been elucidated so far. MATERIAL AND METHODS: Serum fetuin B levels were determined in 37 patients with LD, as well as in a control cohort consisting of 37 non-LD participants matched for age, gender, and body mass index...
November 16, 2017: Cytokine
https://www.readbyqxmd.com/read/29153750/family-history-of-diabetes-is-associated-with-enhanced-adipose-lipolysis-evidence-for-the-implication-of-epigenetic-factors
#7
I Dahlman, M Ryden, P Arner
AIMS: Type 2 diabetes is associated with insulin resistance, adipose hypertrophy and increased lipolysis. The heritability of these traits has been determined by associating them with a family history of diabetes. METHODS: Abdominal subcutaneous fat biopsies were obtained from 581 subjects in a cross-sectional study. Fat cells were isolated, and the difference between measured and expected fat-cell volume was used to determine adipose morphology (degree of hypertrophy or hyperplasia)...
November 11, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29153687/influence-of-non-dipping-pattern-of-blood-pressure-in-gestational-hypertension-on-maternal-cardiac-function-hemodynamics-and-intrauterine-growth-restriction
#8
A Ilic, D J Ilic, S Tadic, M Stefanovic, A Stojsic-Milosavljevic, K Pavlovic, A Redzek, L Velicki
BACKGROUND: An association between gestational hypertension (GH) and changes of maternal cardiac function was previously reported. AIM: The study assessed the effect of non-dipping pattern of blood pressure (BP) in GH on haemodynamic function and intrauterine growth restriction (IUGR). METHODS: This study included 126 women (91 with GH and 35 normotensive controls). Based on the BP values measured by ambulatory blood pressure monitoring (ABPM), all hypertensive women were classified in dipper (46 women) or in non-dipper group (45 women)...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153671/longitudinal-evaluation-of-uterine-perfusion-endothelial-function-and-central-blood-flow-in-early-onset-pre-eclampsia
#9
Ludmila Barcelos Porto, Augusto Henriques Fulgêncio Brandão, Henrique Vítor Leite, Antônio Carlos Vieira Cabral
OBJECTIVES: Physiopathological mechanisms that trigger clinical manifestations in pre-eclampsia (PE) remain unclear, and management is still a challenge. The identification of tools to predict the onset of the disease and prevent its complications is of great interest in medical practice. The present study aims to evaluate uterine perfusion, endothelial function and central nervous system blood flow in pregnant women with high-risk factors for PE, for comparison of the results between the group of patients who developed early onset PE and those who remained normotensive throughout pregnancy...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153568/maternal-obesity-and-cardiac-development-in-the-offspring-study-in-human-neonates-and-minipigs
#10
Maria Angela Guzzardi, Tiziana Liistro, Luna Gargani, Lamia Ait Ali, Gennaro D'Angelo, Silvia Rocchiccioli, Federica La Rosa, Alessandra Kemeny, Elena Sanguinetti, Nadia Ucciferri, Mariarosaria De Simone, Antonietta Bartoli, Pierluigi Festa, Piero A Salvadori, Silvia Burchielli, Rosa Sicari, Patricia Iozzo
OBJECTIVES: The aim of this study was to investigate the consequences of maternal overweight on cardiac development in offspring in infants (short term) and minipigs (short and longer term). BACKGROUND: The epidemic of overweight involves pregnant women. The uterine environment affects organ development, modulating disease susceptibility. Offspring of obese mothers have higher rates of cardiovascular events and mortality. METHODS: Echocardiography was performed in infants born to lean and overweight mothers at birth and at 3, 6, and 12 months of age...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29152657/dihydroartemisinin-treatment-exhibits-antitumor-effects-in-glioma-cells-through-induction-of-apoptosis
#11
Chun-Hua Xu, Yue Liu, Li-Min Xiao, Chang-Gui Guo, Su-Yue Zheng, Er-Ming Zeng, Dong-Hai Li
The present study aimed to investigate the effect of dihydroartemisinin on the proliferation of chemotherapy‑resistant C6 rat glioma cells. The results revealed that incubation of C6 glioma cells with a range of dihydroartemisinin concentrations for 48 h led to a significant (P<0.02) reduction in the cell number. There was a ‑0.8-fold reduction in the cell count following treatment with 20 µM dihydroartemisinin when compared with the control cultures. Analysis of DNA synthesis using bromodeoxyuridine (BrdU) staining demonstrated a reduction in the BrdU‑labeling index (LI) following treatment with 20 µM dihydroartemisinin...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29152245/metabolic-syndrome-and-inflammation-in-adipose-tissue-occur-at-different-times-in-animals-submitted-to-a-high-sugar-fat-diet
#12
Fabiane Valentini Francisqueti, André Ferreira Nascimento, Igor Otávio Minatel, Marcos Correa Dias, Renata de Azevedo Melo Luvizotto, Carolina Berchieri-Ronchi, Ana Lúcia A Ferreira, Camila Renata Corrêa
Obesity is associated with low-grade inflammation, triggered in adipose tissue, which may occur due to an excess of SFA from the diet that can be recognised by Toll-like receptor-4. This condition is involved in the development of components of the metabolic syndrome associated with obesity, especially insulin resistance. The aim of the study was to evaluate the manifestation of the metabolic syndrome and adipose tissue inflammation as a function of the period of time in which rats were submitted to a high-sugar/fat diet (HSF)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29152230/rare-fungal-infectious-agents-a-lurking-enemy
#13
REVIEW
Anna Skiada, Ioannis Pavleas, Maria Drogari-Apiranthitou
In the expanding population of immunocompromised patients and those treated in intensive care units, rare fungal infectious agents have emerged as important pathogens, causing invasive infections associated with high morbidity and mortality. These infections may present either as de novo or as breakthrough invasive infections in high-risk patients with hematologic malignancies receiving prophylactic or empirical antifungal therapy or in patients with central venous catheters. Diagnosis and treatment are challenging...
2017: F1000Research
https://www.readbyqxmd.com/read/29152121/longitudinal-evaluation-of-myocardial-glucose-metabolism-and-contractile-function-in-obese-type-2-diabetic-db-db-mice-using-small-animal-dynamic-18-f-fdg-pet-and-echocardiography
#14
Kuan-Yin Ko, Yen-Wen Wu, Cheng-Wei Liu, Mei-Fang Cheng, Ruoh-Fang Yen, Wei-Shiung Yang
The aim was to evaluate sequential changes of myocardial glucose utilization and LV systolic function in db/db mice. Eight db/db and eight wild-type mice underwent plasma substrate analysis and dynamic (18)F-FDG PET at week 8 (W8), W10, W12, W14, and W16. (18)F-FDG uptake constant Ki and the rate of myocardial glucose uptake (MRGlu) were derived via Patlak graphic analysis. Another 8 db/db and 8 wild-type mice received echocardiography at W8, W12, and W16 and LV structure and function were measured. The db/db mice showed increased weights and glucose levels as they aged...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151980/synbiotic-effects-of-%C3%AE-glucans-from-cauliflower-mushroom-and-lactobacillus-fermentum-on-metabolic-changes-and-gut-microbiome-in-estrogen-deficient-rats
#15
Seong-Yeop Jeong, Suna Kang, Cao Shi Hua, Zhang Ting, Sunmin Park
Background: We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopausal symptoms in ovariectomized (OVX) rats and explored their mechanisms of action, including changes in gut microbiota. Methods: OVX rats were fed with high-fat diets containing 1% dextrin (control), 1% lyophilized cauliflower mushroom extract (CFM), 0...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/29151928/serum-pre-albumin-predicts-the-clinical-outcome-in-metastatic-castration-resistant-prostate-cancer-patients-treated-with-abiraterone
#16
Liancheng Fan, Chenfei Chi, Sanwei Guo, Yanqing Wang, Wen Cai, Xiaoguang Shao, Fan Xu, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Hongyang Qian, Shaowei Xie, Rui Wang, Lixin Zhou, Baijun Dong, Wei Xue
Objective To determine the prognostic utility of serum pre-albumin in metastatic castration-resistant prostate cancer (mCRPC) patients treated with abiraterone (AA). Patients and Methods 112 chemotherapy pretreated or chemotherapy-naive patients were scheduled for systemic treatment with AA. Serum pre-albumin levels were measured before and after 3 months of AA treatment. Univariate and multivariate analyses were performed to determine prognostic factors that were associated with PSA progression-free survival (PSA-PFS), radiographic PFS (rPFS) and overall survival (OS)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151789/discriminative-role-of-brachial-artery-doppler-parameters-in-correlation-with-hemodialysis-arteriovenous-fistula
#17
Burak Mehmet Çildağ, Kutsi Ömer Faruk Köseoğlu
Purpose: The aim of this study was to evaluate the flow volume and resistive index parameters of the brachial artery in the functioning and dysfunctioning radiocephalic and brachiocephalic hemodialysis arteriovenous fistula (AVF). Methods: 82 patients were distributed into three groups according to their hemodialysis function - as normal function, decreased pump flow and increased venous pressure. Flow volumes and resistive indexes (RI) of the brachial artery of radiocephalic and brachiocephalic AVFs were measured by Doppler ultrasound...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29151647/7-10-epoxyoctadeca-7-9-dienoic-acid-a-small-molecule-adjuvant-that-potentiates-%C3%AE-lactam-antibiotics-against-multidrug-resistant-staphylococcus-aureus
#18
Chakradhar Dasagrandhi, Young-Soon Kim, In-Hwan Kim, Ching T Hou, Hak-Ryul Kim
The emergence of methicillin-resistant Staphylococcus aureus (MRSA) infections with multi-drug resistance needs effective and alternative control strategies. In this study we investigated the adjuvant effect of a novel furan fatty acid, 7,10-epoxyoctadeca-7,9-dienoic acid (7,10-EODA) against multidrug-resistant S. aureus (MDRSA) strain 01ST001 by disc diffusion, checker board and time kill assays. Further the membrane targeting action of 7,10-EODA was investigated by spectroscopic and confocal microscopic studies...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29151386/dysregulation-in-children-origins-and-implications-from-age-5-to-age-28
#19
Maureen E McQuillan, Ebru C Kultur, John E Bates, Lauren M O'Reilly, Kenneth A Dodge, Jennifer E Lansford, Gregory S Pettit
Research shows that childhood dysregulation is associated with later psychiatric disorders. It does not yet resolve discrepancies in the operationalization of dysregulation. It is also far from settled on the origins and implications of individual differences in dysregulation. This study tested several operational definitions of dysregulation using Achenbach attention, anxious/depressed, and aggression subscales. Individual growth curves of dysregulation were computed, and predictors of growth differences were considered...
November 20, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29151361/magnesium-sulfate-and-ophthalmic-artery-doppler-velocimetry-in-patients-with-severe-preeclampsia-a-case-series
#20
Cristiane Alves Oliveira, Renato Augusto Moreira de Sa, Karina Vieira Zamprogno, Fabio Gutierrez da Matta, Flávia do Vale Araújo
BACKGROUND: In the present study, we used Doppler velocimetry in the ophthalmic artery to evaluate the hemodynamic status of the intracranial vasculature. This is the first time in the literature that indices of ophthalmic artery Doppler sonography of women with preeclampsia were evaluated before and after the use of magnesium sulfate to prevent eclampsia. CASE PRESENTATION: Indices of ophthalmic artery Doppler sonography of six women with severe preeclampsia at 27 to 33 weeks of gestational age were evaluated before and after the use of magnesium sulfate (10 minutes, 30 minutes, and 60 minutes after the magnesium sulfate loading dosage...
November 20, 2017: Journal of Medical Case Reports
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