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pre-engraftment syndrome

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https://www.readbyqxmd.com/read/27907031/in-vitro-pre-clinical-validation-of-suicide-gene-modified-anti-cd33-redirected-chimeric-antigen-receptor-t-cells-for-acute-myeloid-leukemia
#1
Kentaro Minagawa, Muhammad O Jamil, Mustafa Al-Obaidi, Larisa Pereboeva, Donna Salzman, Harry P Erba, Lawrence S Lamb, Ravi Bhatia, Shin Mineishi, Antonio Di Stasi
BACKGROUND: Approximately fifty percent of patients with acute myeloid leukemia can be cured with current therapeutic strategies which include, standard dose chemotherapy for patients at standard risk of relapse as assessed by cytogenetic and molecular analysis, or high-dose chemotherapy with allogeneic hematopoietic stem cell transplant for high-risk patients. Despite allogeneic hematopoietic stem cell transplant about 25% of patients still succumb to disease relapse, therefore, novel strategies are needed to improve the outcome of patients with acute myeloid leukemia...
2016: PloS One
https://www.readbyqxmd.com/read/27762068/procalcitonin-and-cytokine-profiles-in-engraftment-syndrome-in-pediatric-stem-cell-transplantation
#2
Nirali N Shah, Theresa M Watson, Bonnie Yates, David J Liewehr, Seth M Steinberg, David Jacobsohn, Terry J Fry
BACKGROUND: Diagnosis of engraftment syndrome (ES) following allogeneic hematopoietic stem cell transplantation (HSCT) can be a challenge due to the systemic presentation and alternative etiologies. With a goal of establishing biomarkers to more accurately distinguish ES, we prospectively analyzed levels of cytokines during HSCT. PROCEDURES: We performed a prospective study of children ≤21 years who underwent allogeneic HSCT. Blood samples for interleukin (IL)-6, IL-8, IL-10, IL-1b, IL-12p70, interferon-γ, tumor necrosis factor alpha (TNF-α) and procalcitonin were obtained from each subject prior to conditioning, at day 0, and then biweekly through engraftment and at days 30, 60 and 100...
October 20, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27722122/pre-engraftment-syndrome-clinical-significance-and-pathophysiology
#3
Young-Ho Lee, Wee-Jin Rah
No abstract text is available yet for this article.
September 2016: Blood Research
https://www.readbyqxmd.com/read/27449294/preimplantation-factor-pif-therapy-provides-comprehensive-protection-against-radiation-induced-pathologies
#4
Reut Shainer, Osnat Almogi-Hazan, Arye Berger, Liad Hinden, Martin Mueller, Chaya Brodie, Cedric Simillion, Michael Paidas, Eytan R Barnea, Reuven Or
Acute Radiation Syndrome (ARS) may lead to cancer and death and has few effective countermeasures. Efficacy of synthetic PIF treatment was demonstrated in preclinical autoimmune and transplantation models. PIF protected against inflammation and mortality following lethal irradiation in allogeneic bone marrow transplant (BMT) model. Herein, we demonstrate that PIF imparts comprehensive local and systemic protection against lethal and sub-lethal ARS in murine models. PIF treatment 2 h after lethal irradiation led to 100% survival and global hematopoietic recovery at 2 weeks after therapy...
July 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27446080/deficient-neutrophil-extracellular-trap-formation-in-patients-undergoing-bone-marrow-transplantation
#5
Jared W Glenn, Mark J Cody, Meghann P McManus, Michael A Pulsipher, Joshua D Schiffman, Christian Con Yost
Overwhelming infection causes significant morbidity and mortality among patients treated with bone marrow transplantation (BMT) for primary immune deficiencies, syndromes of bone marrow failure, or cancer. The polymorphonuclear leukocyte (PMN; neutrophil) is the first responder to microbial invasion and acts within the innate immune system to contain and clear infections. PMNs contain, and possibly clear, infections in part by forming neutrophil extracellular traps (NETs). NETs are extensive lattices of extracellular DNA and decondensed chromatin decorated with antimicrobial proteins and degradative enzymes, such as histones, myeloperoxidase, and neutrophil elastase...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27376545/umbilical-cord-blood-transplantation-for-adults-using-tacrolimus-with-two-day-very-short-term-methotrexate-for-graft-versus-host-disease-prophylaxis
#6
Bungo Saito, Norimichi Hattori, Kohei Yamamoto, Nana Arai, Yukiko Kawaguchi, Shun Fujiwara, Nobuyuki Kabasawa, Hiroyuki Tsukamoto, Yui Uto, Hirotsugu Ariizumi, Kouji Yanagisawa, Tsuyoshi Nakamaki
Cord blood transplantation (CBT) is an alternative approach to allogeneic stem cell transplantation. However, CBT is associated with issues including pre-engraftment immune reaction (PIR), engraftment syndrome (ES), and graft failure (GF). Tacrolimus (TAC) and short-term methotrexate (sMTX: days 1, 3, 6, and/or 11) are used for graft-versus-host disease (GVHD) prophylaxis during CBT; however, sMTX does not accelerate neutrophil engraftment. Therefore, we hypothesized that lower doses of sMTX [very-short-term MTX (vsMTX): 10 and 7mg/m(2) on days 1 and 3, respectively] with TAC reduce the risk of GF without increasing post-transplantation immune reactions during CBT...
August 2016: Leukemia Research
https://www.readbyqxmd.com/read/27263776/cord-blood-transplantation-in-japan
#7
Naoyuki Uchida
Cord blood transplantation (CBT) has increasingly been used in Japan and the annual number of CBT now exceeds 1,200. The cumulative number of CBT reached 12,853 in 2015, accounting for almost 1/3 of total CBT performed worldwide. It is true that smaller body size and lower costs, as compared to western countries, have been advantages for Japanese people in using CB as graft alternative. In addition, several novel findings regarding serious issues following CBT have been obtained, which further enhanced the use of CB...
May 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/26760806/allogeneic-hematopoietic-stem-cell-transplantation-in-children-with-primary-immunodeficiencies-hospital-israelita-albert-einstein-experience
#8
Juliana Folloni Fernandes, Fabio Rodrigues Kerbauy, Andreza Alice Feitosa Ribeiro, Jose Mauro Kutner, Luis Fernando Aranha Camargo, Adalberto Stape, Eduardo Juan Troster, Gabriele Zamperlini-Netto, Alessandra Milani Prandini de Azambuja, Bruna Carvalho, Mayra de Barros Dorna, Marluce Dos Santos Vilela, Cristina Miuki Abe Jacob, Beatriz Tavares Costa-Carvalho, Jose Marcos Cunha, Magda Maria Carneiro-Sampaio, Nelson Hamerschlak
OBJECTIVE: To report the experience of a tertiary care hospital with allogeneic hematopoietic stem cell transplantation in children with primary immunodeficiencies. METHODS: Seven pediatric patients with primary immunodeficiencies (severe combined immunodeficiency: n = 2; combined immunodeficiency: n = 1; chronic granulomatous disease: n = 1; hyper-IgM syndrome: n = 2; and IPEX syndrome: n = 1) who underwent eight hematopoietic stem cell transplants in a single center, from 2007 to 2010, were studied...
June 2011: Einstein
https://www.readbyqxmd.com/read/26725351/-genetic-heterogeneity-in-transient-abnormal-myelopoiesis
#9
REVIEW
Satoshi Saida
Leukemia arises through an evolutionary process of somatic mutation and selection. Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder that progresses to myeloid leukemia of Down syndrome (ML-DS) through the accumulation of genetic alterations. To investigate the mechanism underlying leukemogenesis, a xenograft model of TAM was established using NOG mice. Serial engraftment after cell transplantation from a TAM patient who developed ML-DS a year later showed the self-renewal capacity of these cells...
December 2015: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/26526424/graft-versus-host-disease-gvhd-prophylaxis-by-using-methotrexate-decreases-pre-engraftment-syndrome-and-severe-acute-gvhd-and-accelerates-engraftment-after-cord-blood-transplantation
#10
Akihiro Iguchi, Yukayo Terashita, Minako Sugiyama, Junjiro Ohshima, Tomonobu Z Sato, Yuko Cho, Ryoji Kobayashi, Tadashi Ariga
GVHD and graft failure are serious problems in CBT. PES after CBT also occurs frequently and is associated with transplantation-related complications such as acute GVHD. We reviewed medical records for 70 consecutive child CBT recipients between December 1997 and April 2015. Forty-nine patients received prophylaxis against GVHD with CsA or Tac in combination with mPSL from day +7 (mPSL group), and 21 patients received CsA or Tac with MTX on day +1 and day +3 (MTX group). Neutrophil engraftment was detected in 59 patients (84...
February 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/26458456/-human-herpesvirus-6-associated-with-hematopoietic-stem-cell-transplantation
#11
Masao Ogata
Reactivation of human herpesvirus (HHV)-6B is a relatively common occurrence after allogeneic stem cell transplantation (SCT), and it is associated with the development of various post-transplant complications. HHV-6 encephalitis appears to be a significant, life-threatening complication caused by HHV-6B reactivation. HHV-6 encephalitis typically develops 2-6 weeks after SCT, and the symptoms are characterized by memory loss, seizures, and consciousness loss. Magnetic resonance imaging typically shows limbic encephalitis...
October 2015: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/26445329/salvaged-single-unit-cord-blood-transplantation-for-26-patients-with-hematologic-malignancies-not-in-remission
#12
W Yao, C C Zheng, H L Liu, L Q Geng, B L Tang, J Tong, X Y Zhu, K D Song, P Qiang, Z M Sun
Treatments for patients with hematologic malignancies not in remission are limited, but a few clinical studies have investigated the effects of salvaged unrelated cord blood transplantation (CBT). We retrospectively studied 19 patients with acute leukemia, 5 with myelodysplastic syndrome (MDS with refractory anemia with excess blasts [RAEB]), and 2 with non-Hodgkin's lymphoma who received 1 CBT unit ≤ 2 loci human leukocyte antigen (HLA)-mismatched after undergoing myeloablative conditioning regimens between July 2005 and July 2014...
October 2015: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/26134011/-combination-of-busulfan-with-increased-dose-of-fludarabine-as-conditioning-regimen-for-mds-and-mds-aml-patients-with-allo-hsct
#13
Jing Yuan, Hanyun Ren, Zhixiang Qiu, Yuan Li, Mangju Wang, Wei Liu, Weilin Xu, Yuhua Sun, Lihong Wang, Zeyin Liang, Yujun Dong, Jinping Ou, Wensheng Wang, Yue Yin, Xinan Cen, Qian Wang
OBJECTIVE: To investigate the safety and efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS) and secondary acute myelogenous leukemia (MDS-AML) using conditioning regimen with busulfan (Bu) and increased-dose of fludarabine (ID-Flu). METHODS: A total of 49 patients with MDS or MDS-AML were treated by allo-HSCT, the clinical data was analyzed retrospectively. RESULTS: All patients achieved hematopoietic reconstitution...
June 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/25962528/successful-haploidentical-donor-hematopoietic-stem-cell-transplant-and-restoration-of-stat3-function-in-an-adolescent-with-autosomal-dominant-hyper-ige-syndrome
#14
N C Patel, J L Gallagher, T R Torgerson, A L Gilman
PURPOSE: Autosomal dominant hyper-IgE syndrome (AD-HIES), caused by mutations in Signal Transducer and Activator of Transcription 3 (STAT3) is associated with defective STAT3 signaling and Th17 differentiation and recurrent bacterial and fungal infections. Most patients suffer significant morbidity and premature mortality. Hematopoietic stem cell transplantation (HSCT) has been reported in a small number of cases, with mixed outcomes. We report successful haploidentical donor HSCT in a patient with AD-HIES...
July 2015: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/25831204/salvaged-single-unit-cord-blood-transplantation-for-26-patients-with-hematologic-malignancies-not-in-remission
#15
W Yao, C C Zheng, H L Liu, L Q Geng, B L Tang, J Tong, X Y Zhu, K D Song, P Qiang, Z M Sun
Treatments for patients with hematologic malignancies not in remission are limited, but a few clinical studies have investigated the effects of salvaged unrelated cord blood transplantation (CBT). We retrospectively studied 19 patients with acute leukemia, 5 with myelodysplastic syndrome (MDS with refractory anemia with excess blasts [RAEB]), and 2 with non-Hodgkin's lymphoma who received 1 CBT unit ≤2 loci human leukocyte antigen (HLA)-mismatched after undergoing myeloablative conditioning regimens between July 2005 and July 2014...
March 27, 2015: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/25639769/131i-metaiodobenzylguanidine-with-intensive-chemotherapy-and-autologous-stem-cell-transplantation-for-high-risk-neuroblastoma-a-new-approaches-to-neuroblastoma-therapy-nant-phase-ii-study
#16
MULTICENTER STUDY
Gregory A Yanik, Judith G Villablanca, John M Maris, Brian Weiss, Susan Groshen, Araz Marachelian, Julie R Park, Denice Tsao-Wei, Randall Hawkins, Barry L Shulkin, Hollie Jackson, Fariba Goodarzian, Hiro Shimada, Jesse Courtier, Raymond Hutchinson, Daphne Haas-Koga, C Beth Hasenauer, Scarlett Czarnecki, Howard M Katzenstein, Katherine K Matthay
(131)I-Metaiodobenzylguanidine ((131)I-MIBG) has been used as a single agent or in combination with chemotherapy for the treatment of high-risk neuroblastoma. The activity and toxicity of (131)I-MIBG when combined with carboplatin, etoposide, and melphalan (CEM) and autologous stem cell transplantation (SCT) are now investigated in a phase II multicenter study. Fifty patients with MIBG-avid disease were enrolled into 2 cohorts, stratified by response to induction therapy. The primary study endpoint was response of patients with refractory (n = 27) or progressive disease (n = 15)...
April 2015: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/25482740/survey-of-antifungal-prophylaxis-and-fungal-diagnostic-tests-employed-in-malignant-haematology-and-haemopoietic-stem-cell-transplantation-hsct-in-australia-and-new-zealand
#17
REVIEW
S J van Hal, N M Gilroy, C O Morrissey, L J Worth, J Szer, C S Tam, S C Chen, K A Thursky, M A Slavin
This article reports the findings of a survey developed to assess the current use of antifungal prophylaxis among haematology and infectious disease clinicians across Australia and New Zealand, and their alignment with existing consensus guidelines for the use of antifungal agents in the haematology/oncology setting (published 2008). Surveyed clinicians largely followed the current recommendations for prophylaxis in the setting of induction chemotherapy for acute myeloid leukaemia, as well as autologous and low-risk allogeneic haemopoietic stem cell transplantation (HSCT)...
December 2014: Internal Medicine Journal
https://www.readbyqxmd.com/read/25016195/nonmyeloablative-peripheral-blood-haploidentical-stem-cell-transplantation-for-refractory-severe-aplastic-anemia
#18
Jennifer Clay, Austin G Kulasekararaj, Victoria Potter, Francesco Grimaldi, Donal McLornan, Kavita Raj, Hugues de Lavallade, Michelle Kenyon, Antonio Pagliuca, Ghulam J Mufti, Judith C W Marsh
New transplant approaches are urgently needed for patients with refractory severe aplastic anemia (SAA) who lack a matched sibling or unrelated donor (UD) or who have failed UD or cord blood transplant. Patients with refractory SAA are at risk of later clonal evolution to myelodysplastic syndrome and acute leukemia. We report our pilot findings with haploidentical hematopoietic stem cell transplantation (haploHSCT) using uniform reduced-intensity conditioning with postgraft high-dose cyclophosphamide in 8 patients with refractory SAA or patients who rejected a prior UD or cord blood transplant...
November 2014: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/24951122/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematologic-malignancies-2014-update-of-the-recommendations-of-the-infectious-diseases-working-party-of-the-german-society-for-haematology-and-oncology
#19
REVIEW
Daniela Tacke, Dieter Buchheidt, Meinolf Karthaus, Stefan W Krause, Georg Maschmeyer, Silke Neumann, Helmut Ostermann, Olaf Penack, Christina Rieger, Markus Ruhnke, Michael Sandherr, Katharina E Schweer, Andrew J Ullmann, Oliver A Cornely
Invasive fungal infections cause substantial morbidity and mortality in immunocompromised patients, particularly in those with haematological malignancies and recipients of allogeneic haematopoietic stem cell transplantation. Difficulties in diagnosing invasive fungal infections and subsequent delays in treatment initiation lead to unfavourable outcomes and emphasise the importance of prophylaxis. Since the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology in 2009, results of 14 additional clinical studies have been published comprising 2,899 patients and initiating this update...
September 2014: Annals of Hematology
https://www.readbyqxmd.com/read/24346710/pulmonary-manifestations-of-the-pre-engraftment-syndrome-after-umbilical-cord-blood-transplantation
#20
Kyle R Brownback, Steven Q Simpson, Joseph P McGuirk, Tara L Lin, Sunil Abhyankar, Siddhartha Ganguly, Omar S Aljitawi
Pre-engraftment syndrome (PES) is a condition occurring after umbilical cord blood transplantation (UCBT) characterized by fever and erythematous skin rash prior to neutrophil engraftment. We sought to determine the incidence and characterize the pulmonary manifestations of PES. A retrospective review of patients who underwent UCBT at the University of Kansas Medical Center over a 5-year period was performed. Data collected included patient baseline characteristics, presence of PES, pulmonary findings, treatments, and survival...
May 2014: Annals of Hematology
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