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https://www.readbyqxmd.com/read/28920554/a-pulmonary-embolism-response-team-s-initial-20-month-experience-treating-87-patients-with-submassive-and-massive-pulmonary-embolism
#1
Akhilesh K Sista, Oren A Friedman, Eda Dou, Brendan Denvir, Gulce Askin, Jamie Stern, Jaclyn Estes, Arash Salemi, Ronald S Winokur, James M Horowitz
Pulmonary Embolism Response Teams (PERTs) have emerged to provide rapid multidisciplinary assessment and treatment of PE patients. However, descriptive institutional experience and preliminary outcomes data from such teams are sparse. PERT activations were identified through a retrospective review. Only confirmed submassive or massive PEs were included in the data analysis. In addition to baseline variables, the therapeutic intervention, length of stay (LOS), in-hospital mortality, and bleeding rate/severity were recorded...
September 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/28919427/age-dependent-atrial-arrhythmic-phenotype-secondary-to-mitochondrial-dysfunction-in-pgc-1%C3%AE-deficient-murine-hearts
#2
Haseeb Valli, Shiraz Ahmad, Karan Chadda, Ali Al-Hadithi, Andrew A Grace, Kamalan Jeevaratnam, Christopher L-H Huang
INTRODUCTION: Ageing and several age-related chronic conditions including obesity, insulin resistance and hypertension are associated with mitochondrial dysfunction and represent independent risk factors for atrial fibrillation (AF). MATERIALS AND METHODS: Atrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) and aged (>12 month), wild type (WT) and peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(-/-)) murine hearts modeling age-dependent chronic mitochondrial dysfunction during regular pacing and programmed electrical stimulation (PES)...
September 14, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28917987/development-and-characterisation-of-electrospun-timolol-maleate-loaded-polymeric-contact-lens-coatings-containing-various-permeation-enhancers
#3
Prina Mehta, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Despite exponential growth in research relating to sustained and controlled ocular drug delivery; anatomical and chemical barriers of the eye still pose formulation challenges. Nanotechnology integration into the pharmaceutical industry has aided efforts in potential ocular drug device development. Here, the integration and in vitro effect of four different permeation enhancers (PEs) on the release of anti-glaucoma drug timolol maleate (TM) from polymeric nanofiber formulations is explored. Electrohydrodynamic (EHD) engineering, more specifically electrospinning, was used to engineer nanofibers (NFs) which coated the exterior of contact lenses...
September 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28917915/synergistic-effect-of-chitosan-zinc-oxide-hybrid-nanoparticles-on-antibiofouling-and-water-disinfection-of-mixed-matrix-polyethersulfone-nanocomposite-membranes
#4
Iqra Munnawar, Sadia S Iqbal, Muhammad N Anwar, Mehwish Batool, Sheraz Tariq, Nosheen Faitma, Asim L Khan, Asad U Khan, Umair Nazar, Tahir Jamil, Nasir M Ahmad
Antifouling polyethersulfone (PES) membranes for water disinfection were fabricated by incorporating varying concentrations of carbohydrate polymer chitosan and Zinc oxide hybrid nanoparticles (CS-ZnO HNPS). The CS-ZnO HNPS were prepared using chemical precipitation method and were characterized using SEM, XRD and FTIR. The membranes were then fabricated by incorporating nanoparticles of CS-ZnO HNPS with three different concentrations of 5%, 10% and 15% w/w in the casting solution of PES through phase inversion method...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917135/failing-to-learn-from-negative-prediction-errors-obesity-is-associated-with-alterations-in-a-fundamental-neural-learning-mechanism
#5
David Mathar, Jane Neumann, Arno Villringer, Annette Horstmann
Prediction errors (PEs) encode the difference between expected and actual action outcomes in the brain via dopaminergic modulation. Integration of these learning signals ensures efficient behavioral adaptation. Obesity has recently been linked to altered dopaminergic fronto-striatal circuits, thus implying impairments in cognitive domains that rely on its integrity. 28 obese and 30 lean human participants performed an implicit stimulus-response learning paradigm inside an fMRI scanner. Computational modeling and psycho-physiological interaction (PPI) analysis was utilized for assessing PE-related learning and associated functional connectivity...
August 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28913521/solvation-of-li-by-argon-how-important-are-three-body-forces
#6
Frederico V Prudente, Jorge M C Marques, Francisco B Pereira
A new analytical potential for Li(+)Ar2 including three-body interactions has been modeled by employing ab initio energies that were calculated within the CCSD(T) framework and a quadruple-zeta basis-set (i.e., cc-pVQZ for lithium and aug-cc-pVQZ for argon) and, then, corrected for the basis-set superposition error (BSSE) with the counterpoise method. Departing from this function, we have constructed the potential energy surface for Li(+)Arn clusters by summing over all two-body and three-body terms. We have employed our evolutionary algorithm (EA) to perform a global geometry optimization that allows for the study of a Li(+) ion microsolvated with argon atoms...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28913384/anatomical-repair-of-stener-like-lesion-of-medial-collateral-ligament-a-case-series-and-technical-note
#7
Sohrab Keyhani, Mohsen Mardani-Kivi
Medial collateral ligament tears usually will be treated through non-surgical methods, but, in some cases such as those with tears at the distal insertion where the reduction could be blocked by the pes anserine tendons (Stener-like lesion), surgery will be performed. Here, we present a surgical technique in such cases. In this retrospective case series, we describe six patients diagnosed with Stener-like lesion based on clinical evaluation and imaging results. In the one-year follow-up visit, there was no complaining of pain or joint instability and full range of motion and negative valgus stress test were reported in all cases...
July 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28910324/effect-of-dialyzer-membrane-materials-on-survival-in-chronic-hemodialysis-patients-results-from-the-annual-survey-of-the-japanese-nationwide-dialysis-registry
#8
Masanori Abe, Takayuki Hamano, Atsushi Wada, Shigeru Nakai, Ikuto Masakane
BACKGROUND: Little information is available regarding which type of dialyzer membrane results in good prognosis in patients on chronic hemodialysis. Therefore, we conducted a cohort study from a nationwide registry of hemodialysis patients in Japan to establish the association between different dialyzer membranes and mortality rates. METHODS: We followed 142,412 patients on maintenance hemodialysis (female, 39.1%; mean age, 64.8 ± 12.3 years; median dialysis duration, 7 [4-12] years) for a year from 2008 to 2009...
2017: PloS One
https://www.readbyqxmd.com/read/28903330/inhibition-of-hsf1-suppresses-the-growth-of-hepatocarcinoma-cell-lines-in-vitro-and-akt-driven-hepatocarcinogenesis-in-mice
#9
Antonio Cigliano, Chunmei Wang, Maria G Pilo, Marta Szydlowska, Stefania Brozzetti, Gavinella Latte, Giovanni M Pes, Rosa M Pascale, Maria A Seddaiu, Gianpaolo Vidili, Silvia Ribback, Frank Dombrowski, Matthias Evert, Xin Chen, Diego F Calvisi
Upregulation of the heat shock transcription factor 1 (HSF1) has been described as a frequent event in many cancer types, but its oncogenic role in hepatocellular carcinoma (HCC) remains poorly delineated. In the present study, we assessed the function(s) of HSF1 in hepatocarcinogenesis via in vitro and in vivo approaches. In particular, we determined the importance of HSF1 on v-Akt murine thymoma viral oncogene homolog (AKT)-induced liver cancer development in mice. We found that knockdown of HSF1 activity via specific siRNA triggered growth restraint by suppressing cell proliferation and inducing massive cell apoptosis in human HCC cell lines...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28892160/are-litter-decomposition-and-fire-linked-through-plant-species-traits
#10
REVIEW
Johannes H C Cornelissen, Saskia Grootemaat, Lieneke M Verheijen, William K Cornwell, Peter M van Bodegom, René van der Wal, Rien Aerts
Contents I. II. III. IV. V. VI. VII. References SUMMARY: Biological decomposition and wildfire are connected carbon release pathways for dead plant material: slower litter decomposition leads to fuel accumulation. Are decomposition and surface fires also connected through plant community composition, via the species' traits? Our central concept involves two axes of trait variation related to decomposition and fire. The 'plant economics spectrum' (PES) links biochemistry traits to the litter decomposability of different fine organs...
September 11, 2017: New Phytologist
https://www.readbyqxmd.com/read/28889739/photoelectron-spectroscopy-and-density-functional-theory-studies-of-iron-sulfur-fes-m-m-2-8-cluster-anions-co-existing-multiple-spin-states
#11
Shi Yin, Elliot R R Bernstein
Iron sulfur cluster anions (FeS)m- (m = 2 - 8) are studied by photoelectron spectroscopy (PES) at 3.492 eV (355 nm) and 4.661 eV (266 nm) photon energies, and by density functional theory (DFT) calculations. The most probable structures and ground state spin multiplicities for (FeS)m- (m = 2 - 8) clusters are tentatively assigned through a comparison of their theoretical and experiment first vertical detachment energy (VDE) values. Many spin states lie within 0.5 eV of the ground spin state for the larger (FeS)m- (m ≥ 4) clusters...
September 11, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28885843/theoretical-kinetics-analysis-for-%C3%A1-atom-addition-to-1-3-butadiene-and-related-reactions-on-the-%C3%A4-4h7-potential-energy-surface
#12
Yang Li, Stephen J Klippenstein, Chong-Wen Zhou, Henry J Curran
As the simplest conjugated hydrocarbon, 1,3-butadiene oxidation chemistry can provide a first step in understanding the role of poly-unsaturated hydrocarbons in combustion and, in particular, an understanding of their contribution towards soot formation. Based on our previous work on propene and the butene isomers (1-, 2- and isobutene), it was found that the reaction kinetics of H-atom addition to the C=C double bond plays a significant role in fuel consumption kinetics and influences the predictions of high-temperature ignition delay times, product species concentrations and flame speed measurements...
September 8, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28884053/pes-anserinus-bursitis-due-to-tibial-spurs-in-children
#13
Vivek Tiwari, Venkatesan Sampath Kumar, Rishi R Poudel, Ashok Kumar, Shah Alam Khan
Osteochondromas are the most common bone tumours. Although these tumors are relatively common in the long bones of children, the varied clinical and radiographic presentation of such neoplasms around the knee joint can cause diagnostic delays, especially when not associated with a palpable swelling. Proximal tibial osteochondromas can sometimes unusually present as spurs/ rose thorns leading to pes anserinus bursitis and vague knee pain. We describe the clinico-radiographic features of such proximal tibial metaphyseal osteochondromas giving rise to pes anserinus bursitis in three children, including bilaterally symmetrical osteochondroma in one of the cases, who were treated conservatively with good outcomes...
July 5, 2017: Curēus
https://www.readbyqxmd.com/read/28883689/lateral-column-lengthening-for-adolescent-idiopathic-pes-planovalgus-deformity-systematic-review
#14
REVIEW
Sanjay Kumar, S V Sonanis
Pes planovalgus is the commonest foot deformity in children and presents with wide range of severity and symptoms. Surgery is mostly indicated for significant malalignment, resistant to non-surgical management. Lateral column lengthening is considered an appealing option as does not involve arthrodesis and allows for further growth and foot development. METHODS: We conducted a systematic review on lateral column lengthening for pes planovalgus deformity in line with PRISMA-P Checklist...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28881302/nanoparticulation-of-bovine-serum-albumin-and-poly-d-lysine-through-complex-coacervation-and-encapsulation-of-curcumin
#15
L Maldonado, R Sadeghi, J Kokini
Soluble coacervate nanoparticles were fabricated by mixing bovine serum albumin (BSA) and poly-d-lysine with low (LMW-PDL) and high molecular weights (HMW-PDL). The particle size was influenced by molecular weight, mass ratio of polyelectrolytes (PEs), and salt concentration. The smallest nanoparticles had a diameter of 212±11nm which was achieved with LMW-PDL dissolved with 0.1M NaCl at pH 7 and a mass ratio of 2.0 (BSA: PDL). SEM images showed that coacervate nanoparticles of LMW-PDL are relatively spherical in shape, while nanoparticles of HMW-PDL were irregular...
August 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28880040/analysis-of-the-vibronic-structure-of-the-trans-stilbene-fluorescence-and-excitation-spectra-the-s0-and-s1-pes-along-the-ce-double-bond-length-as-m-dash-ce-and-ce-cph-torsions
#16
Giorgio Orlandi, Marco Garavelli, Francesco Zerbetto
We analyze the highly resolved vibronic structure of the low energy (≤200 cm(-1)) region of the fluorescence and fluorescence excitation spectra of trans-stilbene in supersonic beams. In this spectral region the vibronic structure is associated mainly with vibrational levels of the Ce-Ce torsion (τ) and the au combination of the two Ce-Cph bond twisting (ϕ). We base this analysis on the well-established S0(τ, ϕ) two-dimensional potential energy surface (PES) and on a newly refined S1(τ, ϕ) PES. We obtain vibrational eigenvalues and eigenvectors of the anharmonic S0(τ, ϕ) and S1(τ, ϕ) PES using a numerical procedure based on the Meyer's flexible model [R...
September 7, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28875278/investigation-of-peri-implant-tissue-conditions-and-peri-implant-tissue-stability-in-implants-placed-with-simultaneous-augmentation-procedure-a-3-year-retrospective-follow-up-analysis-of-a-newly-developed-bone-level-implant-system
#17
Jonas Lorenz, Henriette Lerner, Robert A Sader, Shahram Ghanaati
BACKGROUND: Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure. METHODS: A total of 47 implants, which were placed simultaneously with a GBR procedure with a synthetic bone substitute material in 20 patients, were investigated clinically and radiologically at least 3 years after loading...
September 5, 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28873757/the-effect-of-adding-a-commercial-phytosterol-ester-mixture-on-the-phase-behavior-of-palm-oil
#18
Eva Daels, Imogen Foubert, Bart Goderis
The objective of this study was to investigate in depth the non-isothermal crystallization and melting behavior of binary blends of palm oil (PO) with a commercial, multi-component phytosterol ester (PE) mixture. DSC and time-resolved synchrotron X-ray diffraction (XRD) experiments were conducted on blends with a PE concentration from 0 to 100% at intervals of 10% for DSC and 20% for XRD. Based on XRD, two different ordered structures were identified in pure the PEs. The structure designated as PEx was truly crystalline and needed a very high degree of supercooling for its nucleation from the melt...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28872713/ultrahigh-efficiency-green-pholeds-with-a-voltage-under-3-v-and-a-power-efficiency-of-nearly-110-lm-w-1-at-luminance-of-10-000-cd-m-2
#19
Dongdong Zhang, Juan Qiao, Deqiang Zhang, Lian Duan
Maintaining high power efficiency (PE) under high brightness is still a pressing problem for the practical application of organic light-emitting diodes (OLEDs). Here, ultrahigh-efficiency green phosphorescent OLEDs (PHOLEDs) with a record-low voltage at luminance above 5000 cd m(-2) are fabricated, by developing a novel anthracene/pyridine derivative as the electron-transporting material (ETM) combined with a material displaying thermally activated delayed fluorescence as the host. The pyridine units of the ETM not only facilitate charge injection, but also enhance the electron-transporting mobility, profiting from the closely packed molecules caused by the intermolecular H-bonding...
September 5, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28868810/five-year-follow-up-of-the-endothelial-progenitor-cell-capturing-stent-versus-the-paxlitaxel-eluting-stent-in-de-novo-coronary-lesions-with-a-high-risk-of-coronary-restenosis
#20
Pier Woudstra, Deborah N Kalkman, Marcel A Beijk, Margo Klomp, Peter Damman, Karel T Koch, Jose P S Henriques, Jan Baan, Marije M Vis, Jan J Piek, Jan G P Tijssen, Robbert J de Winter
OBJECTIVES: To assess the long-term safety and clinical efficacy of the Genous endothelial progenitor cell capturing stent (ECS) compared with the TAXUS Liberté paclitaxel-eluting stent (PES) in lesions with a high risk of restenosis. BACKGROUND: Instead of the use of cytotoxic or cytostatic drugs in drug-eluting stents, a "pro-healing" approach in ECS may overcome impeded healing response due to delayed functional endothelialization of the stent struts. METHODS: In the prospective, randomized TRIAS pilot study 193 patients with coronary artery lesions carrying a high risk of restenosis were included (ECS: n = 98, PES: n = 95)...
September 4, 2017: Catheterization and Cardiovascular Interventions
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