Mia Y Masuda, Grace C Pyon, Huijun Luo, William E LeSuer, Arina Putikova, Adelyn Dao, Danna R Ortiz, Aliviya R Schulze, Nicholas Fritz, Takao Kobayashi, Koji Iijima, Andres J Klein-Szanto, Masataka Shimonosono, Samuel Flashner, Masaki Morimoto, Rish K Pai, Matthew A Rank, Hiroshi Nakagawa, Hirohito Kita, Benjamin L Wright, Alfred D Doyle
BACKGROUND: Eosinophilic esophagitis (EoE) is an increasingly common inflammatory condition of the esophagus; however, the underlying immunologic mechanisms remain poorly understood. The epithelium-derived cytokine IL-33 is associated with type 2 immune responses and elevated in esophageal biopsies from EoE subjects. OBJECTIVE: We hypothesized that overexpression of IL-33 by the esophageal epithelium would promote the immunopathology of EoE. METHODS: We evaluated the functional consequences of esophageal epithelial overexpression of a secreted and active form of IL-33 (saIL-33) in a novel transgenic mouse, EoE33...
February 2, 2024: Journal of Allergy and Clinical Immunology