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IL-33 ST2

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https://www.readbyqxmd.com/read/29774370/il-33-s-st2-ratio-systemic-symptoms-and-basophil-activation-in-pru-p-3-sensitized-allergic-patients
#1
Carina G Uasuf, Caterina Di Sano, Sebastiano Gangemi, Giuseppe Albeggiani, Diego Cigna, Paola Dino, Ignazio Brusca, Mark Gjomarkaj, Elisabetta Pace
BACKGROUND: Although IL-33/ST2 axis is involved in the development of allergic diseases, its contribution in food allergy is still unknown. METHODS: In this study, we assessed the serum levels of IL-33 and its s-ST2 receptor in 53 control patients (without allergic diseases), 47 peach (Pru p 3)-sensitized allergic patients (SAP), and in 68 non-Pru p 3-SAP. Basophil activation test (BAT) was used to assess the basophil activation due to allergen exposure before and after the addition of s-ST2 to the blood samples from 5 Pru p 3-SAP...
May 17, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29763892/interleukin-33-predicts-poor-prognosis-and-promotes-renal-cell-carcinoma-cell-growth-through-its-receptor-st2-and-the-jnk-signaling-pathway
#2
Chang-Wen Wu, Yi-Guo Wu, Cheng Cheng, Zheng-Dong Hong, Zi-Min Shi, Shuang-Quan Lin, Jie Li, Xiao-Yi He, An-Yi Zhu
BACKGROUND/AIMS: Renal cell carcinoma (RCC) is currently the ninth most common cancer in men. Interleukin (IL)-33 expression has previously been associated with a number of cancers; however, its biological role in RCC is poorly understood. In this study, we sought to elucidate the role of IL-33 in RCC. METHODS: Serum IL-33 levels were measured by ELISA. IL-33 expression in clinical RCC samples was examined by immunocytochemistry. The proliferation and apoptosis rate of RCC were determined by CCK8 and flow cytometry...
May 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763370/novel-interleukin-33-and-its-soluble-st2-receptor-as-potential-serum-biomarkers-in-parotid-gland-tumors
#3
Sowa Pawel, Misiolek Maciej, Zielinski Maciej, Mazur Bogdan, Adamczyk-Sowa Monika
An increasing number of patients with parotid gland tumors have been observed in recent years. The relationship between the immune system and tumor formation is thoroughly investigated. However, newly discovered molecules offer a new insight into the pathophysiology of malignancies. It would be ideal to find an easily determinable biomarker of tumor existence, its malignant potential or a biomarker suggesting the probability of disease recurrence. Our study is the first to examine serum concentrations of IL-33 and its sST2 receptor in patients with various types of parotid gland tumors...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29736154/decreased-il-33-production-contributes-to-trophoblast-cell-dysfunction-in-pregnancies-with-preeclampsia
#4
Hong Chen, Xiaobo Zhou, Ting-Li Han, Philip N Baker, Hongbo Qi, Hua Zhang
Preeclampsia (PE) is a life-threatening pregnancy complication which is related to aggradation of risk regarding fetal and maternal morbidity and mortality. Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. Some studies have demonstrated that interleukin-33 (IL-33) is an immunomodulatory cytokine that is associated with the immune regulation of tumor cells. However, little is known whether IL-33 and its receptor ST2/IL-1 R4 could regulate trophoblast cells, which are associated with the pathogenesis of PE...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29729112/the-il-33-st2-myd88-axis-promotes-regulatory-t-cell-proliferation-in-the-murine-liver
#5
Lei Xu, Wei Li, Xiaofan Wang, Lina Zhang, Qianqian Qi, Liyang Dong, Chuan Wei, Yanan Pu, Yalin Li, Jifeng Zhu, Sha Zhou, Feng Liu, Xiaojun Chen, Chuan Su
Hepatic Foxp3+ regulatory T (Treg) cells are crucial for maintaining local immune homeostasis in the liver. However, the environmental cues required for hepatic Treg cell homeostasis are unclear. In this study, we showed that the IL-33 receptor ST2 was preferentially expressed on Treg cells in the mouse liver, but it was more lowly expressed in the spleen, mesenteric lymph nodes, and blood. More importantly, we found that IL-33 promoted the proliferation of hepatic Treg cells through myeloid differentiation factor MyD88 signaling concomitant with increased CDK4 and cyclin D1 expression...
May 5, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29728508/small-molecule-mimetics-of-%C3%AE-helical-domain-of-irak2-attenuate-the-proinflammatory-effects-of-il-33-in-asthma-like-mouse-models
#6
Jinghong Li, Kunio Saruta, Justin P Dumouchel, Jenna M Magat, Joanna L Thomas, Dariush Ajami, Mitra Rebek, Julius Rebek, Timothy D Bigby
IL-33 and its receptor ST2 play important roles in airway inflammation and contribute to asthma onset and exacerbation. The IL-33/ST2 signaling pathway recruits adapter protein myeloid differentiation primary response 88 (MyD88) to transduce intracellular signaling. MyD88 forms a complex with IL-R-associated kinases (IRAKs), IRAK4 and IRAK2, called the Myddosome (MyD88-IRAK4-IRAK2). The myddosome subsequently activates downstream NF-κB and MAPKs p38 and JNK. We established an asthma-like mouse model by intratracheal administration of IL-33...
May 4, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29728120/il-33-st2-plays-a-critical-role-in-endothelial-cell-activation-and-microglia-mediated-neuroinflammation-modulation
#7
Kelei Cao, Xiang Liao, Jiahui Lu, Shu Yao, Fengjiao Wu, Xingxing Zhu, Dongyan Shi, Shuang Wen, Lixin Liu, Hong Zhou
BACKGROUND: Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases. METHODS: In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital microscopy was employed to examine leukocyte-endothelial interactions in the brain vasculature. The degree of neutrophil infiltration was determined by myeloperoxidase (MPO) staining...
May 4, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29722022/an-st2-dependent-role-of-bone-marrow-derived-group-2-innate-lymphoid-cells-in-pulmonary-fibrosis
#8
Yuyue Zhao, Francina Gonzalez De Los Santos, Zhe Wu, Tianju Liu, Sem H Phan
Recent evidence supports that bone marrow (BM)-derived hematopoietic progenitor cells play an important role in lung injury and fibrosis. While these cells give rise to multiple cell types, the ST2 (Il1rl1)-expressing group 2 innate lymphoid cells (ILC2) derived from BM progenitors have been implicated in tissue repair and remodeling, including in lung fibrosis. To further investigate the precise role of BM-derived ILC2 in the pathogenesis of fibrotic lung disease their importance in the bleomycin-induced lung fibrosis model was evaluated by analyzing the effects of selective ST2 deficiency in the BM compartment...
May 3, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29709067/the-pathogenicity-of-il-33-on-steroid-resistant-eosinophilic-inflammation-via-the-activation-of-memory-type-st2-cd4-t-cells
#9
REVIEW
Kiyoshi Hirahara, Naoko Mato, Koichi Hagiwara, Toshinori Nakayama
The lungs are the primary organs of the respiratory system in many animals and have unique epithelial barrier systems to protect the host from continuous invasion of various harmful particles, such as viruses and bacteria. IL-33, a member of the IL-1 family of cytokines, is released from epithelial cells in the mucosal organs and drives the type 2 immune response by activating a number of immune cells in cases of helminth infection. However, IL-33 derived from epithelial cells also causes various allergic diseases via the activation of ST2-positive immune cells, including memory-type (CD62Llow CD44hi ) ST2+ CD4+ T cells in the lung...
April 30, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29694974/il-33-and-its-receptor-st2-after-inhaled-allergen-challenge-in-allergic-asthmatics
#10
Patrick D Mitchell, Brittany M Salter, John Paul Oliveria, Amani El-Gammal, Damian Tworek, Steve G Smith, Roma Sehmi, Gail M Gauvreau, Paul M O Apos Byrne
BACKGROUND: Previous murine models have demonstrated interleukin (IL)-33 to be an important mediator of type-2 inflammation and to promote airway hyperresponsiveness in allergic asthma. A number of inflammatory cells produce IL-33 and eosinophils express ST2 mRNA. The relationship between IL-33 and eosinophils in allergic asthma, however, remains unclear. OBJECTIVE: The aim of this work was to evaluate in vitro the effect of allergen inhalation on IL-33 levels and expression of its receptor (ST2L) on eosinophils in allergic asthmatics, and the effect of IL-33 stimulation on eosinophil activity...
April 25, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29674622/il-33-st2-axis-mediates-hyperplasia-of-intrarenal-urothelium-in-obstructive-renal-injury
#11
Wei-Yu Chen, Jenq-Lin Yang, Yi-Hsiu Wu, Lung-Chih Li, Ru-Fang Li, Ya-Ting Chang, Lo-Hsin Dai, Wan-Chen Wang, Ya-Jen Chang
The monolayered intrarenal urothelium covers the renal papilla and ureteropelvic junction (UPJ). In response to increased renal pressure during obstruction or ischemic injuries, intrarenal urothelial cells begin to proliferate and form a multilayered urothelium. Little is known regarding the mechanism and pathophysiological role of urothelium hyperplasia during renal obstruction. In this study, we investigated the expression of interleukin (IL)-33, an IL-1 family cytokine, in kidneys with unilateral ureteral obstruction (UUO)-induced obstructive injury...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29670241/%C3%AE-%C3%AE-t-cells-producing-interleukin-17a-regulate-adipose-regulatory-t-cell-homeostasis-and-thermogenesis
#12
Ayano C Kohlgruber, Shani T Gal-Oz, Nelson M LaMarche, Moto Shimazaki, Danielle Duquette, Hung N Nguyen, Amir I Mina, Tyler Paras, Ali Tavakkoli, Ulrich von Andrian, Alexander S Banks, Tal Shay, Michael B Brenner, Lydia Lynch
γδ T cells are situated at barrier sites and guard the body from infection and damage. However, little is known about their roles outside of host defense in nonbarrier tissues. Here, we characterize a highly enriched tissue-resident population of γδ T cells in adipose tissue that regulate age-dependent regulatory T cell (Treg ) expansion and control core body temperature in response to environmental fluctuations. Mechanistically, innate PLZF+ γδ T cells produced tumor necrosis factor and interleukin (IL) 17 A and determined PDGFRα+ and Pdpn+ stromal-cell production of IL-33 in adipose tissue...
May 2018: Nature Immunology
https://www.readbyqxmd.com/read/29663450/increased-serum-levels-of-il-33-and-soluble-st2-in-neonates-with-human-cytomegalovirus-infection
#13
Yanru Chen, Jihong Qian
Interleukin 33 (IL-33) and soluble form of ST2 (sST2) are involved in inflammation. This study aimed to assess the role of serum IL-33 and sST2 in neonates with HCMV infection. The concentration of serum IL-33 and sST2 in 20 patients and 16 healthy controls were measure by enzyme-linked immune-sorbent assay (ELISA). The clinical and laboratory data were described. Our results showed serum sST2 and IL-33 levels were significantly higher in the HCMV group than the control group. Significant positive correlation was observed between sST2 and IL-33 (r = 0...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29656959/genetic-variants-in-il-33-st2-pathway-with-the-susceptibility-to-hepatocellular-carcinoma-in-a-chinese-population
#14
Zhong-Heng Wei, Yue-Yong Li, Shi-Qing Huang, Zhong-Qiu Tan
Interleukin (IL)-33/ST2 pathway plays a pivotal role in tumorigenesis through influencing cancer stemness, tumor growth, metastasis, angiogenesis, and accumulation of regulatory T cells in tumor microenvironments. The aim of this study was to investigate the association of IL-33 rs7025417 and ST2 rs3821204 with the risk of hepatocellular carcinoma (HCC). Genotyping of IL-33 rs7025417 and ST2 rs3821204 was carried out using a Taqman assay. IL-33 and ST2 mRNA was examined using real-time PCR and plasma IL-33 and sST2 levels were measured using enzyme-linked immunosorbent assay...
April 12, 2018: Cytokine
https://www.readbyqxmd.com/read/29645082/soluble-st2-sst2-regulation-by-rhinovirus-rv-and-25-oh-vitamin-d3-in-the-blood-of-asthmatic-children
#15
Patricia Haag, Himanshu Sharma, Manfred Rauh, Theodor Zimmermann, Tytti Vuorinen, Nikolaos G Papadopoulos, Scott T Weiss, Susetta Finotto
Paediatric asthma exacerbations are often caused by Rhinovirus (RV). Moreover, 25(OH)-Vitamin D3 (=25(OH) VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible modulation by 25(OH) VitD3 serum levels in a preschool cohort of children with and without asthma. The innate lymphoid cell type 2 (ILC2)-associated marker, ST2 was found upregulated in the blood cells of asthmatic children with low serum levels of 25(OH)VitD3 in the absence of RV in their airways...
April 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29625134/il-17-producing-st2-ilc2-plays-a-pathogenic-role-in-lung-inflammation
#16
Ting Cai, Jinxin Qiu, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng, Lei Shen, Ju Qiu
BACKGROUND: IL-17 plays a pathogenic role in asthma. ST2- iILC2s (inflammatory group 2 innate lymphoid cells) driven by IL-25 can produce IL-17, while ST2+ nILC2s (natural ILC2s) produce few IL-17. OBJECTIVE: We characterized the ST2+ IL-17+ ILC2s during lung inflammation and determined the pathogenesis and molecular regulation of ST2+ IL-17+ ILC2s. METHODS: Lung inflammation was induced by papain or IL-33. IL-17 production by lung ILC2s from wild-type, Rag1-/- , Rorcgfp/gfp and Ahr-/- mice was examined by flow cytometry...
April 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29593738/prostaglandin-e-2-inhibits-group-2-innate-lymphoid-cell-activation-and-allergic-airway-inflammation-through-e-prostanoid-4-cyclic-adenosine-monophosphate-signaling
#17
Yu Zhou, Wei Wang, Conghui Zhao, Yan Wang, Haoming Wu, Xiuyuan Sun, Youfei Guan, Yu Zhang
Evidence is accumulating that group 2 innate lymphoid cells (ILC2) play an important role in allergic airway inflammation by producing a large amount of type 2 cytokines. But it remains poorly understood how its activities are properly controlled in vivo . Here, we demonstrated that prostaglandin E2 (PGE2 ) had a profound inhibitory effect on IL-33-induced ILC2 expansion and IL-5 and IL-13 production in vitro . This effect was mimicked by PGE1 -alcohol but attenuated by ONO-AE3-208, indicating a selective action through the E-prostanoid 4 (EP4) receptor...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29581139/regulation-of-the-il-33-st2-pathway-contributes-to-the-anti-inflammatory-effect-of-acupuncture-in-the-ovalbumin-induced-murine-asthma-model
#18
Ming Dong, Cheng Ma, Wen-Qian Wang, Juan Chen, Ying Wei
BACKGROUND: Bronchial asthma is a chronic airway inflammatory disease which has three main pathological features: airway hyperresponsiveness (AHR), airway remodelling, and chronic inflammation. Acupuncture is known to be an effective integrative medical therapy that has been used in the treatment of several chronic diseases, including bronchial asthma. The aim of the current study was to evaluate the effects of acupuncture on inflammation and regulation of the IL-33/ST2 pathway in a mouse model of asthma...
March 26, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29540770/il-33-st2-signalling-and-crosstalk-with-fc%C3%AE%C2%B5ri-and-tlr4-is-targeted-by-the-parasitic-worm-product-es-62
#19
Dimity H Ball, Lamyaa Al-Riyami, William Harnett, Margaret M Harnett
ES-62 is a secreted parasitic worm-derived immunomodulator that exhibits therapeutic potential in allergy by downregulating aberrant MyD88 signalling to normalise the inflammatory phenotype and mast cell responses. IL-33 plays an important role in driving mast cell responses and promoting type-2 allergic inflammation, particularly with respect to asthma, via MyD88-integrated crosstalk amongst the IL-33 receptor (ST2), TLR4 and FcεRI. We have now investigated whether ES-62 targets this pathogenic network by subverting ST2-signalling, specifically by characterising how the functional outcomes of crosstalk amongst ST2, TLR4 and FcεRI are modulated by the worm product in wild type and ST2-deficient mast cells...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29540209/celastrol-treatment-protects-against-acute-ischemic-stroke-induced-brain-injury-by-promoting-an-il-33-st2-axis-mediated-microglia-macrophage-m2-polarization
#20
Mei Jiang, Xinghui Liu, Denghai Zhang, Ying Wang, Xiaoxia Hu, Fengxia Xu, Mingming Jin, Fanfan Cao, Limin Xu
BACKGROUND: Acute ischemic stroke (AIS) is the most common type of cerebrovascular disease and is a leading cause of disability and death worldwide. Recently, a study suggested that transformation of microglia from the pro-inflammatory M1 state to the anti-inflammatory and tissue-reparative M2 phenotype may be an effective therapeutic strategy for ischemic stroke. Celastrol, a traditional oriental medicine, may have anti-inflammatory and neuroprotective effects. However, the underlying mechanisms remain unknown...
March 14, 2018: Journal of Neuroinflammation
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