Saurav Ranjitkar, Dylan Krajewski, Chelsea Garcia, Caitlin Tedeschi, Stephanie H Polukort, Jeffrey Rovatti, Mohamed Mire, Christopher N Blesso, Evan Jellison, Sallie S Schneider, John J Ryan, Clinton B Mathias
Mast cells (MCs) play critical roles in the establishment of allergic diseases. We recently demonstrated an unexpected, proinflammatory role for IL-10 in regulating MC responses. IL-10 enhanced MC activation and promoted IgE-dependent responses during food allergy. However, whether these effects extend to IgE-independent stimuli is not clear. In this article, we demonstrate that IL-10 plays a critical role in driving IL-33-mediated MC responses. IL-10 stimulation enhanced MC expansion and degranulation, ST2 expression, IL-13 production, and phospho-relA upregulation in IL-33-treated cells while suppressing TNF-α...
March 18, 2024: Journal of Immunology