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IL-33 ST2

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https://www.readbyqxmd.com/read/28316175/-diagnostic-value-of-combining-serum-soluble-st2-and-interleukin-33-for-heart-failure-patients-with-preserved-left-ventricular-ejection-fraction
#1
N S Luo, H F Zhang, P M Liu, Y Q Lin, T C Huang, Y Yang, J F Wang
Objective: Diagnostic efficacy of serum markers is low for heart failure patients with preserved left ventricular ejection fraction (HF-pEF) as compared to heart failure patients with reduced left ventricular ejection fraction.We sought to explore the diagnostic value of serum levels of soluble ST2 (sST2) combined with interleukin-33 (IL-33) for the diagnosis of HF-pEF in this study. Methods: A total of 376 patients with HF-pEF (HF group), 376 matched-control patients without heart failure who shared similar clinical characteristics (non-HF group) were included in the study...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28274612/effects-of-obesity-on-il-33-st2-system-in-heart-adipose-tissue-and-liver-study-in-the-experimental-model-of-zucker-rats
#2
Rosetta Ragusa, Manuela Cabiati, Maria Angela Guzzardi, Andrea D'Amico, Daniela Giannessi, Silvia Del Ry, Chiara Caselli
Suppression of tumorigenicity 2 (ST2) mediates the effect of Interleukin-33 (IL-33). Few data are reported on the relationship between IL-33/ST2 and obesity. We aimed to investigate effects of obesity on IL-33/ST2 system in heart, adipose tissue and liver in a rodent model of obesity. The relationship of cardiac expression of IL-33/ST2 system with natriuretic peptides (NPs) system and inflammatory mediators was also studied. mRNA expression of IL-33/ST2 system was evaluated in cardiac, adipose and hepatic biopsies from obese Zucker rats (O) and controls (CO)...
March 6, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28273074/a-rare-il33-loss-of-function-mutation-reduces-blood-eosinophil-counts-and-protects-from-asthma
#3
Dirk Smith, Hannes Helgason, Patrick Sulem, Unnur Steina Bjornsdottir, Ai Ching Lim, Gardar Sveinbjornsson, Haruki Hasegawa, Michael Brown, Randal R Ketchem, Monica Gavala, Logan Garrett, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Asgeir Sigurdsson, Olafur T Magnusson, Gudmundur I Eyjolfsson, Isleifur Olafsson, Pall Torfi Onundarson, Olof Sigurdardottir, David Gislason, Thorarinn Gislason, Bjorn Runar Ludviksson, Dora Ludviksdottir, H Marike Boezen, Andrea Heinzmann, Marcus Krueger, Celeste Porsbjerg, Tarunveer S Ahluwalia, Johannes Waage, Vibeke Backer, Klaus A Deichmann, Gerard H Koppelman, Klaus Bønnelykke, Hans Bisgaard, Gisli Masson, Unnur Thorsteinsdottir, Daniel F Gudbjartsson, James A Johnston, Ingileif Jonsdottir, Kari Stefansson
IL-33 is a tissue-derived cytokine that induces and amplifies eosinophilic inflammation and has emerged as a promising new drug target for asthma and allergic disease. Common variants at IL33 and IL1RL1, encoding the IL-33 receptor ST2, associate with eosinophil counts and asthma. Through whole-genome sequencing and imputation into the Icelandic population, we found a rare variant in IL33 (NM_001199640:exon7:c.487-1G>C (rs146597587-C), allele frequency = 0.65%) that disrupts a canonical splice acceptor site before the last coding exon...
March 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28266165/il33-and-il1rl1-variants-are-associated-with-asthma-and-atopy-in-a-brazilian-population
#4
G A Queiroz, R S Costa, N M Alcantara-Neves, G Nunes de Oliveira Costa, M L Barreto, V L Carneiro, C A Figueiredo
Atopic asthma is a chronic inflammatory disease in airways resulting from genetic and environmental factors, characterized by production of the Th2 cytokines interleukin-4 (IL-4), interleukin-5 (IL-5) and interleukin-13 (IL-13). Interleukin-33 (IL-33) appears to be a potent inducer of Th2 immune response. This occurs when IL-33 binds and activates its receptor, the membrane ST2 (ST2L) in mast cells, dendritic cells, basophils, eosinophils, innate lymphoids and Th2 cells, leading to the release of these cytokines and intensifying allergic inflammation...
April 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/28262704/il-33-st2-immune-responses-to-respiratory-bacteria-in-pediatric-asthma
#5
Isabell Hentschke, Anna Graser, Volker O Melichar, Alexander Kiefer, Theodor Zimmermann, Bettina Kroß, Patricia Haag, Paraskevi Xepapadaki, Nikolaos G Papadopoulos, Christian Bogdan, Susetta Finotto
Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the EU-wide study PreDicta. In this cohort of pre-school asthmatic children, nasopharyngeal colonization with Gram-negative bacteria such as Haemophilus influenzae and Moraxella catarrhalis was found to be associated with the highest interferon beta (IFNβ) and IL-33 levels in the nasal pharyngeal fluids (NPF). IL33R-ST2 was found induced in the blood of asthmatic children with additional Gram + bacteria in the nasopharynx (Gr+/-)...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28259547/clock-dependent-temporal-regulation-of-il-33-st2-mediated-mast-cell%C3%A2-response
#6
Takahiro Kawauchi, Kayoko Ishimaru, Yuki Nakamura, Nobuhiro Nakano, Mutsuko Hara, Hideoki Ogawa, Ko Okumura, Shigenobu Shibata, Atsuhito Nakao
BACKGROUND: Interleukin-33 (IL-33) is an alarmin cytokine that binds to the interleukin 1 receptor-like 1 protein ST2. Clock is a key circadian gene that is essential for endogenous clockworks in mammals. This study investigated whether Clock temporally regulated IL-33-mediated responses in mast cells. METHODS: The kinetics of IL-33-mediated IL-6, IL-13, and TNF-α productions were compared between bone marrow-derived mast cells (BMMCs) from wild-type and Clock-mutated mice (Clock(Δ19/Δ19) mice)...
March 2, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28258042/il-33-induces-both-regulatory-b-cells-and-regulatory-t-cells-in-dextran-sulfate-sodium-induced-colitis
#7
Junfeng Zhu, Ying Xu, Chunyu Zhu, Jian Zhao, Xinrui Meng, Siyao Chen, Tianqi Wang, Xue Li, Li Zhang, Changlong Lu, Hongsheng Liu, Xun Sun
Interleukin (IL)-33 is a member of the IL-1 family. Serum levels of IL-33 are increased in inflammatory bowel diseases (IBD), suggesting that IL-33 is involved in the pathogenesis of IBD, although its role is not clear. In this study, we investigated the role of IL-33 in the regulation of T-helper (Th) cell and B cell responses in mesenteric lymph nodes (MLN) in mice with dextran sulfate sodium (DSS)-induced colitis. Here, we showed that IL-33-treated mice were susceptible to DSS-induced colitis as compared with PBS-treated mice...
February 28, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28252235/toll-like-receptor-induced-expression-of-epithelial-cytokine-receptors-on-hemopoietic-progenitors-is-altered-in-allergic-asthma
#8
Damian Tworek, Delia Heroux, Seamus N O'Byrne, Patrick Mitchell, Paul M O'Byrne, Judah A Denburg
BACKGROUND: Hemopoietic progenitor cells (HPC) migrate to sites of allergic inflammation where, upon stimulation with epithelial cytokines, they produce Th2 cytokines and differentiate into mature eosinophils and basophils. They also express Toll-like receptors (TLR) involved in anti-microbial responses. OBJECTIVE: The objective of this study was to compare TLR expression on peripheral blood HPC and TLR-induced responses, in particular changes in epithelial cytokine receptors, in healthy and asthmatic subjects at baseline and following allergen challenge...
March 1, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28249897/il-33-promotes-colon-cancer-cell-stemness-via-jnk-activation-and-macrophage-recruitment
#9
Min Fang, Yongkui Li, Kai Huang, Shanshan Qi, Jian Zhang, Witold Zgodzinski, Marek Majewski, Grzegorz Wallner, Stanislaw Gozdz, Pawel Macek, Artur Kowalik, Marcin Pasiarski, Ewelina Grywalska, Linda Vatan, Nisha Nagarsheth, Wei Li, Lili Zhao, Ilona Kryczek, Guobin Wang, Zheng Wang, Weiping Zou, Lin Wang
The expression and biological role of IL-33 in colon cancer is poorly understood. In this study, we show that IL-33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of human IL-33 and overexpression of murine IL-33 enhanced human and murine colon cancer cell growth in vivo, respectively. IL-33 stimulated cell sphere formation and prevented chemotherapy-induced tumor apoptosis. Mechanistically, IL-33 activated core stem cell genes NANOG, NOTCH3, and OCT3/4 via the ST2 signaling pathway, and induced phosphorylation of c-Jun N-terminal kinase activation (JNK), and enhanced binding of c-Jun to the promoters of the core stem cell genes...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28205524/interleukin-33-produced-by-m2-macrophages-and-other-immune-cells-contributes-to-th2-immune-reaction-of-igg4-related-disease
#10
Sachiko Furukawa, Masafumi Moriyama, Kensuke Miyake, Hitoshi Nakashima, Akihiko Tanaka, Takashi Maehara, Mana Iizuka-Koga, Hiroto Tsuboi, Jun-Nosuke Hayashida, Noriko Ishiguro, Masaki Yamauchi, Takayuki Sumida, Seiji Nakamura
IgG4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and marked infiltration of IgG4-positive cells in multiple organs. Interleukin-33 (IL-33) is a recently described cytokine that is secreted by damaged epithelial cells, macrophages, and dendritic cells, and potently activates helper T type 2 (Th2) immune responses, which have been suggested to play a major role in IgG4 production of IgG4-RD. Here, we assessed the expression of IL-33 and related molecules in the salivary glands (SGs) of patients with IgG4-RD versus that in patients with Sjögren's syndrome (SS) and controls...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28198366/th17-cells-express-st2-and-are-controlled-by-the-alarmin-il-33-in-the-small-intestine
#11
A Pascual-Reguant, J Bayat Sarmadi, C Baumann, R Noster, D Cirera-Salinas, C Curato, P Pelczar, S Huber, C E Zielinski, M Löhning, A E Hauser, E Esplugues
TH17 cells are major drivers of inflammation and involved in several autoimmune diseases. Tissue inflammation is a beneficial host response to infection, but it can also contribute to autoimmunity. The crosstalk between a tissue and the immune system during an inflammatory response is key for preserving tissue integrity and restoring physiological processes. However, how the inflamed tissue regulates the magnitude of an immune response by controlling pro-inflammatory T cells is not well characterized so far...
February 15, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28196875/a-signalling-cascade-of-il-33-to-il-13-regulates-metaplasia-in-the-mouse-stomach
#12
Christine P Petersen, Anne R Meyer, Carlo De Salvo, Eunyoung Choi, Cameron Schlegel, Alec Petersen, Amy C Engevik, Nripesh Prasad, Shawn E Levy, R Stokes Peebles, Theresa T Pizarro, James R Goldenring
OBJECTIVE: Alternatively activated macrophages (M2) are associated with the progression of spasmolytic polypeptide-expressing metaplasia (SPEM) in the stomach. However, the precise mechanism(s) and critical mediators that induce SPEM are unknown. DESIGN: To determine candidate genes important in these processes, macrophages from the stomach corpus of mice with SPEM (DMP-777-treated) or advanced SPEM (L635-treated) were isolated and RNA sequenced. Effects on metaplasia development after acute parietal cell loss induced by L635 were evaluated in interleukin (IL)-33, IL-33 receptor (ST2) and IL-13 knockout (KO) mice...
February 14, 2017: Gut
https://www.readbyqxmd.com/read/28196763/il-33-dysregulates-regulatory-t-cells-and-impairs-established-immunologic-tolerance-in-the-lungs
#13
Chien-Chang Chen, Takao Kobayashi, Koji Iijima, Fan-Chi Hsu, Hirohito Kita
BACKGROUND: Airway exposure to environmental antigens generally leads to immunologic tolerance. A fundamental question remains: Why is airway tolerance compromised in patients with allergic airway diseases? IL-33 promotes innate and adaptive type 2 immunity and might provide the answer to this question. OBJECTIVE: The goal of this study was to investigate the roles played by IL-33 in altering regulatory T (Treg) cells in the lungs and in affecting previously established airway immunologic tolerance...
February 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28194023/interleukin-33-drives-hepatic-fibrosis-through-activation-of-hepatic-stellate-cells
#14
Zhongming Tan, Qianghui Liu, Runqiu Jiang, Long Lv, Siamak S Shoto, Isabelle Maillet, Valerie Quesniaux, Junwei Tang, Wenjie Zhang, Beicheng Sun, Bernhard Ryffel
Liver fibrosis is a consequence of chronic liver disease, causing morbidity and mortality. Interleukin-33 (IL-33) is a critical mediator of inflammation, which may be involved in the development of liver fibrosis. Here, we investigated the role of IL-33 in human patients and experimental bile-duct ligation (BDL)-induced fibrosis in mice. We report increased hepatic IL-33 expression in the murine BDL model of fibrosis and in surgical samples obtained from patients with liver fibrosis. Liver injury, inflammatory cell infiltration and fibrosis were reduced in the absence of the IL-33/ST2 receptor, and the activation of hepatic stellate cells (HSCs) was decreased in ST2-deficient mice...
February 13, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28176939/factors-associated-with-plasma-il-33-levels-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Sei Won Kim, Chin Kook Rhee, Ki Uk Kim, Sang Haak Lee, Hun Gyu Hwang, Yu Il Kim, Deog Kyeom Kim, Sang Do Lee, Yeon-Mok Oh, Hyoung Kyu Yoon
BACKGROUND: Interleukin (IL)-33 promotes T helper (Th)2 immunity and systemic inflammation. The role of IL-33 in asthma has been widely investigated. IL-33 has also been suggested to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the clinical significance and usefulness of plasma IL-33 level in patients with COPD. METHODS: A total of 307 patients with stable COPD from 15 centers, who were in the Korean Obstructive Lung Disease cohort, were enrolled in this study...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28172971/p498-emerging-role-of-the-il-33-st2-axis-in-predicting-mucosal-response-to-anti-tnf-therapy-in-ulcerative-colitis
#16
L R Lopetuso, V Petito, C Graziani, D Scannone, F Scaldaferri, T T Pizarro, A Gasbarrini
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172456/op027-il-33-st2-axis-sustains-gut-mucosal-wound-healing-and-cancerogenesis-in-colitis-associated-colorectal-cancer
#17
L R Lopetuso, C De Salvo, L Di Martino, W Goodman, F Scaldaferri, A Gasbarrini, T T Pizarro
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169287/il-10-producing-st2-expressing-foxp3-t-cells-in-multiple-sclerosis-brain-lesions
#18
Stephanie Elizabeth Johanna Zandee, Richard Anthony O'Connor, Iris Mair, Melanie Dawn Leech, Anna Williams, Stephen Mark Anderton
CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function...
February 7, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28168040/role-of-the-il-33-st2-axis-in-sepsis
#19
REVIEW
Hui Xu, Heth R Turnquist, Rosemary Hoffman, Timothy R Billiar
Sepsis remains a major clinical problem with high morbidity and mortality. As new inflammatory mediators are characterized, it is important to understand their roles in sepsis. Interleukin 33 (IL-33) is a recently described member of the IL-1 family that is widely expressed in cells of barrier tissues. Upon tissue damage, IL-33 is released as an alarmin and activates various types of cells of both the innate and adaptive immune system through binding to the ST2/IL-1 receptor accessory protein complex. IL-33 has apparent pleiotropic functions in many disease models, with its actions strongly shaped by the local microenvironment...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28149862/prospects-to-translate-the-biology-of-il-33-and-st2-during-organ-transplantation-into-therapeutics-to-treat-graft-versus-host-disease
#20
EDITORIAL
Ian C Scott, Kirsty F Houslay, E Suzanne Cohen
No abstract text is available yet for this article.
December 2016: Annals of Translational Medicine
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