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https://www.readbyqxmd.com/read/28535166/adult-height-prevalent-coronary-calcium-score-and-incident-cardiovascular-outcomes-in-a-multi-ethnic-cohort
#1
Joseph Yeboah, Michael J Blaha, Erin D Michos, Waqas Qureshi, Michael Miedema, Peter Flueckiger, Carlos J Rodriguez, Moyses Szklo, Alain G Bertoni
We assessed the relationships among adult height, coronary artery calcium (CAC) scores, incident atherosclerotic cardiovascular disease (ASCVD) events, and atrial fibrillation (Afib) in a multi-ethnic cohort. We used race/ethnicity -specific height (dichotomized by median and quartiles) as the predictor variable within the four race/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (N = 6,814). After a mean of 10.2 years of follow-up (2000-2012), 556 ASCVD events (8.2%) and 539 afib events (7.9%) occurred...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28528881/impact-of-calcium-score-on-agreement-between-multidetector-computed-tomography-and-invasive-coronary-angiography
#2
José Alberto de Agustín, José Juan Gómez de Diego, Pedro Marcos-Alberca, Patricia Mahía, José Luis Rodrigo, María Luaces, Iván Javier Núñez-Gil, Joaquín Ferreiros, Ana Bustos, Beatriz Cabeza, Miguel Ángel García-Fernández, Carlos Macaya, Leopoldo Pérez de Isla
INTRODUCTION AND OBJECTIVES: Multidetector computed tomography (MDCT) has been demonstrated as a feasible alternative to invasive coronary angiography (ICA). However, contradictory results have been reported regarding the effect of coronary artery calcium score (CS) on the diagnostic accuracy of MDCT. Our aim was to assess the agreement of MDCT and ICA and to evaluate the influence of CS on this agreement. METHODS: We enrolled 266 consecutive patients who underwent evaluation with 64-slice MDCT and ICA...
May 18, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28528743/-18-f-sodium-fluoride-positron-emission-tomography-for-molecular-imaging-of-coronary-atherosclerosis-based-on-computed-tomography-analysis
#3
Toshiro Kitagawa, Hideya Yamamoto, Shinya Toshimitsu, Ko Sasaki, Atsuhiro Senoo, Yumiko Kubo, Fuminari Tatsugami, Kazuo Awai, Yutaka Hirokawa, Yasuki Kihara
BACKGROUND AND AIMS: We aimed at evaluating the relation of (18)F-sodium fluoride ((18)F-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT). METHODS: Thirty-two patients with one or more coronary atherosclerotic lesions detected on cardiac CT underwent (18)F-NaF PET/CT. Each coronary atherosclerotic lesion was evaluated on CT angiography for plaque types (calcified plaque [CP], non-calcified plaque [NCP], partially calcified plaque [PCP]), and the presence of CT-based high-risk features (minimum CT density <30 Hounsfield units and vascular remodeling index >1...
April 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28523594/the-relationship-between-coronary-artery-calcium-scores-and-left-atrium-size-in-hemodialysis-patients
#4
Ismail Baloglu, Kultigin Turkmen, H Zeki Tonbul, N Yılmaz Selcuk
PURPOSE: Hemodialysis patients have extremely increased cardiovascular mortality. The coronary artery calcification score (CACS) in uremic patients receiving hemodialysis reflects the severity of atherosclerotic vascular disease and predicts the cardiovascular events. In cardiac conditions, left atrial (LA) size has a prognostic importance. In this study, relationship between coronary artery calcification and left atrial size was investigated. METHODS: This was a cross-sectional study involving 32 hemodialysis patients (16 females, 16 males; mean age, 52...
May 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28521653/matrix-metalloproteinase-3-gene-polymorphism-rs3025058-affects-markers-atherosclerosis-in-type-2-diabetes-mellitus
#5
Aleš Pleskovič, Marija Šantl Letonja, Andreja Cokan Vujkovac, Jovana Nikolajević Starčević, Martin Caprnda, Eduard Curilla, Ioana Mozos, Peter Kruzliak, Robert Prosecky, Daniel Petrovič
BACKGROUND: The study was designed to test the possible association between either polymorphisms of the matrix metalloproteinase-9 (MMP-9) gene (rs17576, rs3918242) or the MMP-3 5A/6A gene polymorphism (rs3025058) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The second aim of the study was to demonstrate an association between either the rs17576, rs3918242 or rs3025058 and subclinical markers of coronary artery disease in the same subset of patients with T2DM...
May 19, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28504047/intravascular-ultrasound-validation-of-contemporary-angiographic-scores-evaluating-the-severity-of-calcification-in-peripheral-arteries
#6
Da Yin, Akiko Maehara, Thomas M Shimshak, Joseph J Ricotta, Venkatesh Ramaiah, Malcolm T Foster, Thomas P Davis, Mitsuaki Matsumura, Gary S Mintz, William A Gray
PURPOSE: To validate 3 angiographic scoring systems for peripheral artery calcification using intravascular ultrasound (IVUS) as the gold standard. METHODS: The study employed preprocedure angiography and IVUS data from 47 patients (median age 72 years; 34 men) in the 55-patient JetStream G3 Calcium Study ( ClinicalTrials.gov identifier NCT01273623) to validate the 3 angiographic scoring systems [Peripheral Academic Research Consortium (PARC), Peripheral Arterial Calcium Scoring System (PACSS), and the DEFINITIVE Ca(++) trial]...
May 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28502500/the-association-between-dietary-cholesterol-intake-and-subclinical-atherosclerosis-in-korean-adults-the-kangbuk-samsung-health-study
#7
Eun-Jung Rhee, Seungho Ryu, Jong-Young Lee, Sung Ho Lee, EunSun Cheong, Se Eun Park, Cheol-Young Park, Yu Sam Won, Joon Mo Kim, Dong-Sik Cho, Hye-Kyung Chung, Ki Chul Sung
BACKGROUND: The Scientific Report of the Dietary Guidelines Advisory Committee (2015) concluded that restriction of dietary cholesterol is unnecessary in most adults for the prevention of cardiovascular disease. OBJECTIVE: We aimed to assess the risk for subclinical atherosclerosis according to coronary artery calcium score (CACS), based on dietary cholesterol intake in apparently healthy Korean adults. METHODS: This was a cross-sectional study performed in 30,068 participants (mean age 40...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28501727/methods-to-evaluate-arterial-structure-and-function-in-children-state-of-the-art-knowledge
#8
REVIEW
Piotr Skrzypczyk, Małgorzata Pańczyk-Tomaszewska
BACKGROUND: With increasing rates of hypertension, obesity, and diabetes in the pediatric population, wide available, and reproducible methods are necessary to evaluate arterial structure and function in children and adolescents. METHODS: MEDLINE/Pubmed was searched for articles published in years 2012-2017 on methodology of, current knowledge on, and limitations of the most commonly used methods to evaluate central, proximal and coronary arteries, as well as endothelial function in pediatric patients...
May 11, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28500370/long-term-prognostic-performance-of-low-dose-coronary-computed-tomography-angiography-with-prospective-electrocardiogram-triggering
#9
Olivier F Clerc, Basil P Kaufmann, Mathias Possner, Riccardo Liga, Jan Vontobel, Fran Mikulicic, Christoph Gräni, Dominik C Benz, Tobias A Fuchs, Julia Stehli, Aju P Pazhenkottil, Oliver Gaemperli, Philipp A Kaufmann, Ronny R Buechel
OBJECTIVES: To assess long-term prognosis after low-dose 64-slice coronary computed tomography angiography (CCTA) using prospective electrocardiogram-triggering. METHODS: We included 434 consecutive patients with suspected or known coronary artery disease referred for low-dose CCTA. Patients were classified as normal, with non-obstructive or obstructive lesions, or previously revascularized. Coronary artery calcium score (CACS) was assessed in 223 patients. Follow-up was obtained regarding major adverse cardiac events (MACE): cardiac death, myocardial infarction and elective revascularization...
May 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28493399/diagnosis-of-fatty-liver-by-computed-tomography-coronary-artery-calcium-score
#10
Sarah E Kerut, John T Balart, Edmund K Kerut, Michael R McMullan
Nonalcoholic fatty liver disease may range from simple steatosis to fibrosis and cirrhosis. It is associated with the development of coronary artery calcification and appears to be an independent predictor of future adverse cardiovascular events. As the presence of a fatty liver appears to portray an independent increased risk, it may be beneficial to note this on coronary artery calcium scoring reports. Determination of fatty liver is relatively easy to perform. We discuss the method used by the Multi-Ethnic Study of Atherosclerosis (MESA) study for determination of fatty liver from CT coronary artery calcium scoring acquisitions, which may be implemented in clinical analysis...
May 11, 2017: Echocardiography
https://www.readbyqxmd.com/read/28492571/-teamwork-for-cardiac-imaging-coronary-computed-tomography-angiography-and-low-dose-radiation-exposure-a-cardiology-center-experience
#11
Massimo Magnacca, Rosa Poddighe, Jacopo Del Meglio, Alessio Lilli, Marco Tullio Baratto, Maria Laura Canale, Carlo Tessa, Luca Salvatori, Alessandra Niespolo, Claudio Vignali, Giancarlo Casolo
BACKGROUND: Multidetector coronary computed tomography angiography (CCTA) is increasingly used for noninvasive imaging of the coronary arteries. Radiation exposure, however, is a potential limitation to a more extensive use of this imaging modality. We aimed to demonstrate that a professional teamwork approach, including a cardiologist and a radiologist in performing CCTA, may allow to obtain best quality exams with very low radiation doses. METHODS: A total of 998 consecutive patients underwent CCTA in accordance with the most recent guidelines...
April 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28491082/altered-serum-level-of-cartilage-oligomeric-matrix-protein-and-its-association-with-coronary-calcification-in-patients-with-coronary-heart-disease
#12
Fang-Fang Wang, Lahati Ha, Hai-Yi Yu, Lin Mi, Jiang-Li Han, Wei Gao
BACKGROUND: Cartilage oligomeric matrix protein (COMP) is mainly found in the skeletal system and vascular smooth muscle cells. Recent researches showed that it had a protective function on blood vessels and could also inhibit vascular calcification. We investigated the serum COMPs in coronary heart disease (CHD) patients, and the relationship between serum COMP and the calcification of coronary artery. METHODS: A total of 233 consecutive chest pain patients who first underwent coronary angiography followed by multi-slice computed tomography (MSCT) within six months were recruited and divided into two groups according to the coronary angiography luminal diameter narrowing percentages: CHD group (diameter narrowing ≥ 50%, n = 194) and control group (diameter narrowing < 50%, n = 39)...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28487137/clinical-risk-factors-alone-are-inadequate-for-predicting-significant-coronary-artery-disease
#13
Frederick K Korley, Constantine Gatsonis, Bradley S Snyder, Richard T George, Thura Abd, Stefan L Zimmerman, Harold I Litt, Judd E Hollander
OBJECTIVE: We sought to derive and validate a model for identifying suspected ACS patients harboring undiagnosed significant coronary artery disease (CAD). METHODS: This was a secondary analysis of data from a randomized control trial (RCT). Patients randomized to the CTA arm of an RCT examining a CTA-based strategy for ruling-out acute coronary syndrome (ACS) constitute the derivation cohort, which was randomly divided into a training dataset (2/3, used for model derivation) and a test dataset (1/3, used for internal validation (IV))...
April 27, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28483581/prognostic-value-of-segment-involvement-score-compared-to-other-measures-of-coronary-atherosclerosis-by-computed-tomography-a-systematic-review-and-meta-analysis
#14
Chadi Ayoub, Fernanda Erthal, Mahmoud A Abdelsalam, M Hassan Murad, Zhen Wang, Patricia J Erwin, Graham S Hillis, Leonard Kritharides, Benjamin J W Chow
BACKGROUND: The segment involvement score (SIS) is a semiquantitative measure of the extent of atherosclerosis burden by coronary computed tomography angiography (CTA). We sought to evaluate by meta-analysis the prognostic value of SIS, and to compare it with other CTA measures of coronary artery disease (CAD). METHODS: Electronic databases from 1946 to January 2016 were searched. Studies reporting SIS, or an equivalent measure by coronary CTA, and clinical outcomes were included...
May 3, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28480672/coronary-artery-calcium-score-where-do-we-stand-current-uses-and-implications-in-asymptomatic-patients
#15
Nili Schamroth, Ariel Gutstein, Ran Kornowski
No abstract text is available yet for this article.
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28479451/prognostic-value-of-aortoiliac-calcification-score-in-kidney-transplantation-recipients
#16
Bertrand Chavent, Nicolas Maillard, Claire Boutet, Jean-Noël Albertini, Ambroise Duprey, Jean-Pierre Favre
BACKGROUND: Kidney recipients are increasingly older with arterial disease and extended arterial calcifications. In a kidney transplantation population, the prognosis value of aortic and iliac calcifications remains poorly explored. We aimed to assess the impact of pre-transplantation Aortoiliac vascular calcifications on patients, grafts survival and cardiovascular events. METHODS: This retrospective study included kidney transplantation patients from 2006 to 2012 for whom we had available pre-surgery abdominal computed tomography results (n=100)...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28473443/relationship-of-autoantibodies-to-mda-ldl-and-apob-immune-complexes-to-sex-ethnicity-subclinical-atherosclerosis-and-cardiovascular-events
#17
Anand Prasad, Paul Clopton, Colby Ayers, Amit Khera, James A de Lemos, Joseph L Witztum, Sotirios Tsimikas
OBJECTIVE: Modifications of lipid constituents within atherosclerotic lesions generate neoepitopes that activate innate and adaptive immune responses. We aimed to define the prevalence, distribution, and relationship of autoantibody titers of oxidized lipoproteins to subclinical atherosclerosis and major adverse cardiovascular events (MACE) in different ethnic groups. APPROACH AND RESULTS: IgG and IgM autoantibodies to malondialdehyde-modified low-density lipoprotein (MDA-LDL) and apolipoprotein B-100-immune complexes were measured in 3509 individuals (1814 blacks, 1031 whites, 589 Hispanics, and 85 no race identifier) from the Dallas Heart Study with median 10...
May 4, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28457624/high-mir-124-3p-expression-identifies-smoking-individuals-susceptible-to-atherosclerosis
#18
Maurice W J de Ronde, Maayke G M Kok, Perry D Moerland, Jan Van den Bossche, Annette E Neele, Amalia Halliani, Ingeborg van der Made, Menno P J de Winther, Joost C M Meijers, Esther E Creemers, Sara-Joan Pinto-Sietsma
BACKGROUND AND AIMS: The risk of developing cardiovascular disease (CVD) is twice as high among smoking individuals compared to non-smokers. Monocytes are involved in smoking-related atherosclerotic plaque formation. In this study, we investigated whether smokers with an increased risk of developing CVD can be identified on the basis of monocyte-derived miRNA expression levels. METHODS: We performed a miRNA microarray experiment on isolated monocytes from smoking, former smoking and non-smoking individuals in a cohort of patients with premature CVD and healthy controls (Cohort I, n = 76)...
April 5, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28453572/assessment-of-coronary-artery-calcium-by-chest-ct-compared-with-ekg-gated-cardiac-ct-in-the-multicenter-aids-cohort-study
#19
Divay Chandra, Aman Gupta, Joseph K Leader, Meghan Fitzpatrick, Lawrence A Kingsley, Eric Kleerup, Sabina A Haberlen, Matthew J Budoff, Mallory Witt, Wendy S Post, Frank C Sciurba, Alison Morris
RATIONALE: Individuals with HIV are at increased risk for coronary artery disease (CAD). Early detection of subclinical CAD by assessment of coronary artery calcium (CAC) may help risk stratify and prevent CAD events in these individuals. However, the current standard to quantify CAC i.e. Agatston scoring requires EKG-gated cardiac CT imaging. OBJECTIVE: To determine if the assessment of CAC using non-EKG-gated chest CT and the Weston scoring system is a useful surrogate for Agatston scores in HIV-infected and HIV-uninfected individuals...
2017: PloS One
https://www.readbyqxmd.com/read/28449466/higher-coronary-artery-calcification-score-is-associated-with-adverse-prognosis-in-patients-with-stable-angina-pectoris
#20
Renrong Wang, Xiaoxiao Liu, Chunxia Wang, Xinhe Ye, Xin Xu, Chengjian Yang
BACKGROUND: Coronary artery calcification (CAC) indicates the presence of atherosclerotic lesions and serves as a marker of prognosis in patients with coronary artery disease (CAD). This study evaluated the value of the CAC score for determining the prognosis of patients with stable angina pectoris (SAP). METHODS: A total of 106 consecutive patients with SAP were enrolled in this study from January 2011 to June 2014; from these patients, 640 multi-slice computer tomography (MSCT) samples were used to obtain CAC scores...
March 2017: Journal of Thoracic Disease
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