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https://www.readbyqxmd.com/read/28645476/relation-of-coronary-artery-calcium-score-and-risk-of-cancer-from-a-danish-population-based-follow-up-study-in-patients-who-underwent-cardiac-computed-tomography
#1
Nicklas Vinter, Amanda M S Christesen, Leif S Mortensen, Jes S Lindholt, Søren P Johnsen, Anne Tjønneland, Lars Frost
Evidence of a causal link between atherosclerosis and cancer is sparse and conflicting. Therefore, we examined the association between extent of coronary atherosclerosis determined by coronary artery calcium score (CACS) and risk of cancer. We conducted a historical population-based cohort study of 28,549 cancer-free patients identified in the Western Denmark Heart Registry. All patients underwent cardiac computed tomography for measurement of CACS for suspected coronary artery disease. The outcome was an incident cancer diagnosis: total, tobacco-related, lung, prostate, breast, and colorectal...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28645471/association-of-obstructive-sleep-apnea-with-subclinical-cardiovascular-disease-predicted-by-coronary-artery-calcium-score-in-asymptomatic-subjects
#2
Min Young Seo, Jin-Young Lee, Joo-Yong Hahn, Gwanghui Ryu, Sang Duk Hong, Hun-Jong Dhong, Seung-Kyu Chung, Hyo Yeol Kim
The aim of this study is to determine the association among various sleep parameters for obstructive sleep apnea (OSA) and subclinical cardiovascular disease measured by coronary artery calcium (CAC) score. A cross-sectional study was conducted among 461 patients who underwent both polysomnography (PSG) and coronary artery computed tomography to evaluate CAC score. For each participant, coronary artery computed tomography was conducted within 12 months of PSG. We evaluated the possible association among various PSG parameters by evaluating overnight-attended PSG and CAC...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28637586/soluble-lr11-associates-with-aortic-root-calcification-in-asymptomatic-treated-male-patients-with-familial-hypercholesterolemia
#3
Ranitha Vongpromek, Sven Bos, Gert-Jan R Ten Kate, Hideaki Bujo, Meizi Jiang, Koen Nieman, Wolfgang Schneider, Jeanine E Roeters van Lennep, Adrie J M Verhoeven, Eric J G Sijbrands, Monique T Mulder
BACKGROUND AND AIMS: Despite statin treatment, a high prevalence of severe vascular calcification is found in patients with familial hypercholesterolemia (FH). We assessed the relation between the circulating soluble form of low-density lipoprotein receptor relative with 11 ligand-binding repeats (sLR11), a risk factor for cardiovascular disease, and vascular calcification in asymptomatic statin-treated heterozygous FH patients. METHODS: In 123 asymptomatic heterozygous FH patients (age 40-69 years), aortic root (ARC), aortic valve (AVC) and coronary artery calcification (CAC) were determined with CT-based calcium scoring expressed in Agatston units...
June 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28629567/ct-coronary-calcium-scoring-with-tin-filtration-using-iterative-beam-hardening-calcium-correction-reconstruction
#4
Christian Tesche, Carlo N De Cecco, U Joseph Schoepf, Taylor M Duguay, Moritz H Albrecht, Domenico De Santis, Akos Varga-Szemes, Virginia W Lesslie, Ullrich Ebersberger, Richard R Bayer, Christian Canstein, Ellen Hoffmann, Thomas Allmendinger, John W Nance
OBJECTIVES: To investigate the diagnostic accuracy of CT coronary artery calcium scoring (CACS) with tin pre-filtration (Sn100kVp) using iterative beam-hardening correction (IBHC) calcium material reconstruction compared to the standard 120kVp acquisition. BACKGROUND: Third generation dual-source CT (DSCT) CACS with Sn100kVp acquisition allows significant dose reduction. However, the Sn100kVp spectrum is harder with lower contrast compared to 120kVp, resulting in lower calcium score values...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624402/development-and-validation-of-a-simple-to-use-nomogram-for-predicting-5-10-and-15-year-survival-in-asymptomatic-adults-undergoing-coronary-artery-calcium-scoring
#5
Bríain Ó Hartaigh, Heidi Gransar, Tracy Callister, Leslee J Shaw, Joshua Schulman-Marcus, Wijnand J Stuijfzand, Valentina Valenti, Iksung Cho, Jackie Szymonifka, Fay Y Lin, Daniel S Berman, Hyuk-Jae Chang, James K Min
OBJECTIVES: The purpose of this study was to develop and validate a simple-to-use nomogram for prediction of 5-, 10-, and 15-year survival among asymptomatic adults. BACKGROUND: Simple-to-use prognostication tools that incorporate robust methods such as coronary artery calcium scoring (CACS) for predicting near-, intermediate- and long-term mortality are warranted. METHODS: In a consecutive series of 9,715 persons (mean age: 53.4 ± 10.5 years; 59...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28616562/coronary-calcification-compromises-myocardial-perfusion-irrespective-of-luminal-stenosis
#6
Michael Y Henein, Tarek Bengrid, Rachel Nicoll, Ying Zhao, Bengt Johansson, Axel Schmermund
AIM: The aim of this study was to evaluate the relationship between coronary artery calcification (CAC) assessed by multi-detector computed tomography (MDCT) and myocardial perfusion assessed by cardiac magnetic resonance imaging (CMR) in a group of symptomatic patients. METHOD: Retrospective analysis of 120 patients (age 65.1 ± 8.9 years, 88 males) who presented with atypical chest pain to Bethanien Hospital, Frankfurt, Germany, between 2007 and 2010 and who underwent CAC scoring using MDCT, CMR, and conventional coronary angiography...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28614421/zero-calcium-score-as-a-filter-for-further-testing-in-patients-admitted-to-the-coronary-care-unit-with-chest-pain
#7
Luis Cláudio Lemos Correia, Fábio P Esteves, Manuela Carvalhal, Thiago Menezes Barbosa de Souza, Nicole de Sá, Vitor Calixto de Almeida Correia, Felipe Kalil Beirão Alexandre, Fernanda Lopes, Felipe Ferreira, Márcia Noya-Rabelo
Background: The accuracy of zero coronary calcium score as a filter in patients with chest pain has been demonstrated at the emergency room and outpatient clinics, populations with low prevalence of coronary artery disease (CAD). Objective: To test the gatekeeping role of zero calcium score in patients with chest pain admitted to the coronary care unit (CCU), where the pretest probability of CAD is higher than that of other populations. Methods: Patients underwent computed tomography for calcium scoring, and obstructive CAD was defined by a minimum 70% stenosis on invasive angiography...
June 12, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28607763/in%C3%A2-vitro-evaluation-of-a-new-iterative-reconstruction-algorithm-for-dose-reduction-in-coronary-artery-calcium-scoring
#8
Tobias Gassenmaier, Thomas Allmendinger, Andreas S Kunz, Maike Veyhl-Wichmann, Süleyman Ergün, Thorsten A Bley, Bernhard Petritsch
BACKGROUND: Coronary artery calcium (CAC) scoring is a widespread tool for cardiac risk assessment in asymptomatic patients and accompanying possible adverse effects, i.e. radiation exposure, should be as low as reasonably achievable. PURPOSE: To evaluate a new iterative reconstruction (IR) algorithm for dose reduction of in vitro coronary artery calcium scoring at different tube currents. MATERIAL AND METHODS: An anthropomorphic calcium scoring phantom was scanned in different configurations simulating slim, average-sized, and large patients...
May 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28600674/-value-of-cardiac-ct-in-the-diagnostic-work-up-of-coronary-artery-disease-update-2017
#9
M Meyer, T Henzler
The quantification of coronary calcifications using noncontrast-enhanced computed tomography (CT) as well as coronary CT angiography (cCTA) have rapidly evolved in the recent years. Nowadays, both techniques are increasingly clinically accepted regarding risk stratification and accurate exclusion of significant coronary artery disease (CAD). The higher acceptance of cCTA is mainly based on the higher robustness, lower radiation exposure through continuous technical innovations as well as by the growing scientific evidence...
June 9, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28597124/relative-atherosclerotic-plaque-volume-by-ct-coronary-angiography-trumps-conventional-stenosis-assessment-for-identifying-flow-limiting-lesions
#10
Nahoko Kato, Satoru Kishi, Armin Arbab-Zadeh, Frank J Rybicki, Shuzou Tanimoto, Jiro Aoki, Mika Watanabe, Yu Horiuchi, Koichi Furui, Kazuhiro Hara, Kenji Ibukuro, Joao A C Lima, Kengo Tanabe
The new methods for diagnosing the ischemia with coronary computed tomographic angiography (CTA) as a noninvasive test have been investigated. To compare the relative plaque volume to quantitative CTA and quantitative coronary angiography (QCA) for detecting flow-limiting coronary artery stenoses. We studied 49 patients with 55 intermediate lesions (30-69% diameter stenosis) who underwent CTA, coronary angiography (CAG), and FFR. CTA and QCA measures included lesion length, percent diameter stenosis (%DS), minimal lumen diameter (MLD), target main vessel percent plaque volume (%PV), lesion %PV, target main vessel percent lumen volume (%LV), and lesion %LV...
June 8, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28575097/influence-of-the-definition-of-metabolically-healthy-obesity-on-the-progression-of-coronary-artery-calcification
#11
Ji Won Yoon, Chan-Hyeon Jung, Min-Kyung Kim, Hyo Eun Park, Kyong Soo Park, Hak Chul Jang, Min Kyong Moon, Su-Yeon Choi, Bo Kyung Koo
OBJECTIVES: Debates whether metabolically healthy obesity (MHO) increases the cardiovascular risk might be due to the metabolic instability of MHO or the absence of a perfect definition of MHO. Therefore, we aimed to investigate the influence of the MHO phenotype on the coronary artery calcium score (CACS) progression according to definition of MHO. METHODS: We analyzed a retrospective cohort with a CACS of 0 at baseline and available serial CACS measurements taken ≥ 12 months apart (n = 1,218)...
2017: PloS One
https://www.readbyqxmd.com/read/28574346/generative-adversarial-networks-for-noise-reduction-in-low-dose-ct
#12
Jelmer M Wolterink, Tim Leiner, Max A Viergever, Ivana Isgum
Noise is inherent to low-dose CT acquisition. We propose to train a convolutional neural network (CNN) jointly with an adversarial CNN to estimate routine-dose CT images from low-dose CT images and hence reduce noise. A generator CNN was trained to transform low-dose CT images into routine-dose CT images using voxel-wise loss minimization. An adversarial discriminator CNN was simultaneously trained to distinguish the output of the generator from routinedose CT images. The performance of this discriminator was used as an adversarial loss for the generator...
May 26, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28572221/the-2016-update-to-nice-cg95-guideline-for-the-investigation-of-new-onset-stable-chest-pain-more-innovation-but-at-a-cost
#13
Khaled Alfakih, John P Greenwood, Sven Plein
The National Institute for Health and Care Excellence (NICE) published an update on its guideline on chest pain of recent onset in 2016. The new guideline makes three key changes to the 2010 version. NICE recommend that the previously proposed pre-test probability risk score should no longer be used. They also recommend that a calcium score of zero should no longer be used to rule out coronary artery disease in patients with low pre-test probability. However, the most radical change is that NICE now recommend that all patients with new onset chest pain should be investigated with a computerised tomography coronary angiogram as a first-ine investigation...
June 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28549614/validation-and-comparison-of-four-models-to-calculate-pretest-probability-of-obstructive-coronary-artery-disease-in-a-chinese-population-a-coronary-computed-tomographic-angiography-study
#14
Jia Zhou, Yujie Liu, Lingyu Huang, Yahang Tan, Xingchen Li, Hong Zhang, Yanhe Ma, Ying Zhang
OBJECTIVE: We sought to compare the performance of the updated Diamond-Forrester method (UDFM), Duke clinical score (DCS), Genders clinical model (GCM) and Genders extended model (GEM) in a Chinese population referred to coronary computed tomography angiography (coronary CTA). BACKGROUND: The reliability of existing models to calculate the pretest proability (PTP) of obstructive coronary artery disease (CAD) have not been fully investigated, especially in a Chinese population...
July 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28547671/is-coronary-calcium-scoring-too-late-total-body-arterial-calcium-burden-in-patients-without-known-cad-and-normal-mpi
#15
Adel H A Allam, Randall C Thompson, Michael A Eskander, Mohamed A Mandour Ali, Ayman Sadek, Chris J Rowan, M Linda Sutherland, James D Sutherland, Bruno Frohlich, David E Michalik, Caleb E Finch, Jagat Narula, Gregory S Thomas, L Samuel Wann
BACKGROUND: Patients with normal myocardial perfusion imaging (MPI) have a good prognosis. However, pre-clinical coronary and extracoronary atherosclerosis may exist in the absence of myocardial ischemia. METHODS: 154 Egyptian patients (mean age 53 years) underwent whole-body non-contrast CT following normal MPI. RESULTS: Atherosclerosis in the form of calcification was observed in ≥1 vascular bed in 115 of 154 (75%) patients. This included the iliofemoral (62%), abdominal aorta (53%), thoracic aorta (47%), coronary (47%), and carotid (25%) vascular beds...
May 25, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28535166/adult-height-prevalent-coronary-calcium-score-and-incident-cardiovascular-outcomes-in-a-multi-ethnic-cohort
#16
Joseph Yeboah, Michael J Blaha, Erin D Michos, Waqas Qureshi, Michael Miedema, Peter Flueckiger, Carlos J Rodriguez, Moyses Szklo, Alain G Bertoni
We assessed the relationships among adult height, coronary artery calcium (CAC) scores, incident atherosclerotic cardiovascular disease (ASCVD) events, and atrial fibrillation (Afib) in a multi-ethnic cohort. We used race/ethnicity -specific height (dichotomized by median and quartiles) as the predictor variable within the four race/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (N = 6,814). After a mean of 10.2 years of follow-up (2000-2012), 556 ASCVD events (8.2%) and 539 afib events (7.9%) occurred...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28528881/impact-of-calcium-score-on-agreement-between-multidetector-computed-tomography-and-invasive-coronary-angiography
#17
José Alberto de Agustín, José Juan Gómez de Diego, Pedro Marcos-Alberca, Patricia Mahía, José Luis Rodrigo, María Luaces, Iván Javier Núñez-Gil, Joaquín Ferreiros, Ana Bustos, Beatriz Cabeza, Miguel Ángel García-Fernández, Carlos Macaya, Leopoldo Pérez de Isla
INTRODUCTION AND OBJECTIVES: Multidetector computed tomography (MDCT) has been demonstrated as a feasible alternative to invasive coronary angiography (ICA). However, contradictory results have been reported regarding the effect of coronary artery calcium score (CS) on the diagnostic accuracy of MDCT. Our aim was to assess the agreement of MDCT and ICA and to evaluate the influence of CS on this agreement. METHODS: We enrolled 266 consecutive patients who underwent evaluation with 64-slice MDCT and ICA...
May 18, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28528743/-18-f-sodium-fluoride-positron-emission-tomography-for-molecular-imaging-of-coronary-atherosclerosis-based-on-computed-tomography-analysis
#18
Toshiro Kitagawa, Hideya Yamamoto, Shinya Toshimitsu, Ko Sasaki, Atsuhiro Senoo, Yumiko Kubo, Fuminari Tatsugami, Kazuo Awai, Yutaka Hirokawa, Yasuki Kihara
BACKGROUND AND AIMS: We aimed at evaluating the relation of (18)F-sodium fluoride ((18)F-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT). METHODS: Thirty-two patients with one or more coronary atherosclerotic lesions detected on cardiac CT underwent (18)F-NaF PET/CT. Each coronary atherosclerotic lesion was evaluated on CT angiography for plaque types (calcified plaque [CP], non-calcified plaque [NCP], partially calcified plaque [PCP]), and the presence of CT-based high-risk features (minimum CT density <30 Hounsfield units and vascular remodeling index >1...
April 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28523594/the-relationship-between-coronary-artery-calcium-scores-and-left-atrium-size-in-hemodialysis-patients
#19
Ismail Baloglu, Kultigin Turkmen, H Zeki Tonbul, N Yılmaz Selcuk
PURPOSE: Hemodialysis patients have extremely increased cardiovascular mortality. The coronary artery calcification score (CACS) in uremic patients receiving hemodialysis reflects the severity of atherosclerotic vascular disease and predicts the cardiovascular events. In cardiac conditions, left atrial (LA) size has a prognostic importance. In this study, relationship between coronary artery calcification and left atrial size was investigated. METHODS: This was a cross-sectional study involving 32 hemodialysis patients (16 females, 16 males; mean age, 52...
May 18, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28521653/matrix-metalloproteinase-3-gene-polymorphism-rs3025058-affects-markers-atherosclerosis-in-type-2-diabetes-mellitus
#20
Aleš Pleskovič, Marija Šantl Letonja, Andreja Cokan Vujkovac, Jovana Nikolajević Starčević, Martin Caprnda, Eduard Curilla, Ioana Mozos, Peter Kruzliak, Robert Prosecky, Daniel Petrovič
BACKGROUND: The study was designed to test the possible association between either polymorphisms of the matrix metalloproteinase-9 (MMP-9) gene (rs17576, rs3918242) or the MMP-3 5A/6A gene polymorphism (rs3025058) with markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The second aim of the study was to demonstrate an association between either the rs17576, rs3918242 or rs3025058 and subclinical markers of coronary artery disease in the same subset of patients with T2DM...
May 19, 2017: VASA. Zeitschrift Für Gefässkrankheiten
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