keyword
MENU ▼
Read by QxMD icon Read
search

Arthritis histoplasmosis

keyword
https://www.readbyqxmd.com/read/27830097/histoplasmosis-induced-hemophagocytic-lymphohistiocytosis-in-an-adult-patient-a-case-report-and-review-of-the-literature
#1
Ramona Vesna Untanu, Syed Akbar, Stephen Graziano, Neerja Vajpayee
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threating immune dysregulation syndrome characterized by persistent activation of the mononuclear phagocytic system leading to uncontrolled systemic hyperinflammatory response. The proliferation and activation of histiocytes and lymphocytes lead to production of large amounts of cytokines, also called cytokine storm. Hematopoietic and lymphoid tissues are directly involved while other organs are damaged by circulating cytokines. Primary HLH is attributed to genetic defects of the immune system and secondary HLH is usually seen in adults secondary to malignancy, infection, or autoimmune diseases...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27432853/infectious-complications-with-the-use-of-biologic-response-modifiers-in-infants-and-children
#2
H Dele Davies
Biologic response modifiers (BRMs) are substances that interact with and modify the host immune system. BRMs that dampen the immune system are used to treat conditions such as juvenile idiopathic arthritis, psoriatic arthritis, or inflammatory bowel disease and often in combination with other immunosuppressive agents, such as methotrexate and corticosteroids. Cytokines that are targeted include tumor necrosis factor α; interleukins (ILs) 6, 12, and 23; and the receptors for IL-1α (IL-1A) and IL-1β (IL-1B) as well as other molecules...
August 2016: Pediatrics
https://www.readbyqxmd.com/read/26197989/disseminated-histoplasmosis-partially-mimicking-a-dermatomyositis-in-a-patient-with-rheumatoid-arthritis
#3
A S Dussouil, J Allardet-Servent, L Dunogeant, J L Grauer, S Ranque, V Nasser
Histoplasma capsulatum var. capsulatum is a dimorphic fungus endemic to America and subtropical regions. Several cases of this opportunist mycosis have been reported in immunocompromised patients. We report the case of a patient treated with methotrexate and corticosteroid therapy for rheumatoid arthritis and who presented with disseminated histoplasmosis that partially mimicked a dermatomyositis.
September 2015: British Journal of Dermatology
https://www.readbyqxmd.com/read/26119849/histoplasmosis-diagnosed-after-arthroscopy-of-the-knee-case-report
#4
Lorenzo Falster, Maurício B Marin, João Luiz Ellera Gomes
Fungal arthritis is a rare complication of arthroscopic surgeries, but its possibility should always be considered due its deleterious effects on any joint. Infection caused by the fungus Histoplasma capsulatum is the most common cause of respiratory tract infections by fungi, meanwhile histoplasmosis arthritis is more rare than all other fungal infections. However, their atypical forms of arthritis and the importance of early diagnosis and treatment cannot be over-emphasized. Herein we report a case of knee monoarthritis in an immunocompetent patient with histoplasmosis arthritis following an arthroscopic meniscetomy, diagnosed by synovial biopsy and culture performed during a second arthroscopic procedure...
September 2015: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25802128/-disseminated-histoplamosis-in-adolescent-mimicking-granulomatosis-with-polyangiitis
#5
Marlon van Weelden, Gabriela R Viola, Katia T Kozu, Nadia E Aikawa, Claudia M Ivo, Clovis A Silva
INTRODUCTION: Systemic histoplasmosis is an invasive fungal infection that may mimic primary vasculitis, particularly granulomatosis with polyangiitis (GPA), and was rarely described in adult patients. We reported an immunocompetent patient with disseminated histoplasmosis mimicking GPA who fulfilled European League Against Rheumatism (EULAR)/Pediatric Rheumatology International Trials Organisation (PRINTO)/Pediatric Rheumatology European Society (PRES) validated classification criteria...
March 4, 2015: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/25334849/endobronchial-valve-use-in-persistent-pneumothorax-bronchopleural-fistula-secondary-to-histoplasmosis
#6
Niral Patel, Andrew Worden, Rajul Patel, Javier Diaz-Mendoza, Lisa Stagner
Bronchology/Interventional Student/Resident Case Report Posters ISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Endobronchial valves (EBV) were marketed for use in severe emphysematous COPD. However, they have demonstrated efficacy in managing persistent Bronchopleural Fistulas (Pneumothoraces). In 2008, the FDA approved the use of the IBV Valve System via the Humanitarian Device Exemption Program. There is still limited literature detailing the use of these valves in treating persistent air leaks, few involving thoracic infections, and none involving fungal infections...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25317874/case-records-of-the-massachusetts-general-hospital-case-32-2014-a-78-year-old-woman-with-chronic-sore-throat-and-a-tonsillar-mass
#7
Marlene L Durand, Derrick T Lin, Amy F Juliano, Peter M Sadow
Presentation of Case. Dr. Pritha Sen (Medicine): A 78-year-old woman with diabetes mellitus and rheumatoid arthritis was admitted to Massachusetts Eye and Ear Infirmary because of pain in the right side of the throat, odynophagia, and a right tonsillar mass. The patient had been in her usual health..
October 16, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/25279472/rupioid-psoriasis-and-other-skin-diseases-with-rupioid-manifestations
#8
Hye J Chung, Daria Marley-Kemp, Matthew Keller
The term rupioid has been used to describe well-demarcated, cone-shaped plaques with thick, dark, lamellate, and adherent crusts on the skin that somewhat resemble oyster or limpet shells. We present a case of rupioid psoriasis that was treated with methotrexate, topical steroids, and intralesional steroid injections. Rupioid manifestations have been clinically observed in a variety of disease settings, including rupioid psoriasis, reactive arthritis, disseminated histoplasmosis, keratotic scabies, secondary syphilis, and photosensitive skin lesions in association with aminoaciduria...
September 2014: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/25043266/nondisseminated-histoplasmosis-of-the-trachea
#9
Nicholas Bhojwani, Jason Brett Hartman, David C Taylor, Mark Herbert, Michael Corriveau
Histoplasma capsulatum can rarely affect the trachea. We report the case of a 68-year-old woman with rheumatoid arthritis on immunosuppressive therapy who presented with fevers, worsening shortness of breath, nonproductive cough and subjective throat hoarseness and fullness. Chest computed tomography demonstrated no tracheal findings. Bronchoscopy found mucosal irregularity, nodularity and vesicular regions in the proximal trachea extending seven centimeters distal to the vocal cords. Also seen was an edematous, exudative left vocal cord with polyps and an ulcerative lesion...
March 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/25013413/histoplasmosis-presenting-as-granulomatous-hepatitis-case-report-and-review-of-the-literature
#10
Nancy A Rihana, Manasa Kandula, Ana Velez, Kumud Dahal, Edward B O'Neill
Background. Histoplasma capsulatum is the most common endemic mycosis in the United States and is a frequent cause of opportunistic infection in immunodeficient hosts. Histoplasmosis is most often self-limiting and goes unrecognized in the immunocompetent population but can progress to disseminated histoplasmosis in patients with an impaired immune system. Liver involvement as a part of disseminated histoplasmosis which usually originates in the lung is well known. However, extrapulmonary hepatic histoplasmosis as a primary manifestation is extremely rare...
2014: Case Reports in Medicine
https://www.readbyqxmd.com/read/24831684/-a-55-year-old-woman-with-cough-fever-swelling-of-joints-and-exanthema-after-a-trip-to-ecuador
#11
I Müller-Stöver, K Tintelnot, J Richter, D Häussinger
A 55-year-old woman presented 18 months after a trip to Ecuador with night sweat, malaise, and an unclear lesion of the lung. Computed tomography of the lung showed a nodular lesion of 14 mm. Antibodies against Histoplasma capsulatum were detected in the complement fixation text (CFT) and IgG western blot. Re-examination of a formalin fixed paraffin embedded (FFPE) lung-biopsy revealed yeasts after silver staining, compatible with H. capsulatum , which was verified by extraction and amplification of DNA from FFPE...
August 2014: Der Internist
https://www.readbyqxmd.com/read/24029651/temporal-trends-clinical-characteristics-and-outcomes-of-histoplasmosis-in-a-tertiary-care-center-in-kentucky-2000-to-2009
#12
Thein Myint, Majdi N Al-Hasan, Julie A Ribes, Brian S Murphy, Richard N Greenberg
The impact of highly active antiretroviral therapy (HAART) on the epidemiology of AIDS-associated histoplasmosis in the past decade is poorly defined. Among 100 patients with histoplasmosis in an endemic region between 2000 and 2009, 42 patients were immunocompetent, 32 were infected with HIV, and 26 were non-HIV-immunocompromised patients. The percentage with HIV decreased 67% in 2000-2001 to 18% in 2008-2009 (P = .004), while the proportion of non-HIV immunocompromised patients increased, 8% to 41% (P = ...
March 2014: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/23279234/prolonged-fever-and-splinter-hemorrhages-in-an-immunocompetent-traveler-with-disseminated-histoplasmosis
#13
Roni Bitterman, Ilana Oren, Yuval Geffen, Hannah Sprecher, Eli Schwartz, Ami Neuberger
We present a case of progressive disseminated histoplasmosis in an immunocompetent traveler. Histoplasmosis was acquired in South America; its manifestations included prolonged fever, splinter hemorrhages, erythema multiforme, arthritis, and mediastinal lymphadenopathy. To the best of our knowledge no splinter hemorrhages had previously been reported in a patient with histoplasmosis.
January 2013: Journal of Travel Medicine
https://www.readbyqxmd.com/read/22042634/fatal-histoplasma-capsulatum-mitral-endocarditis-in-a-french-patient-treated-for-rheumatoid-arthritis
#14
Lorraine Letranchant, Anne Debourgogne, Thanh Doco-Lecompte, Nelly Contet-Audonneau, Thierry May, Marie Machouart
Histoplasmosis is an infectious disease caused by the inhalation of Histoplasma capsulatum spores, a fungus encountered in many diverse areas around the world. Although this infection is often asymptomatic, it may become dramatic in immunocompromised patients. In November 2005, an endocarditis due to Histoplasma capsulatum was diagnosed in a French woman treated for rheumatoid arthritis and who had traveled to South America 2 years earlier. We confirmed the biological diagnosis by mycological, serological, and histological methods...
March 2012: Mycopathologia
https://www.readbyqxmd.com/read/21605439/histoplasmosis-infection-in-patients-with-rheumatoid-arthritis-1998-2009
#15
Timothy C Olson, Tim Bongartz, Cynthia S Crowson, Glenn D Roberts, Robert Orenstein, Eric L Matteson
BACKGROUND: Patients with rheumatic diseases including rheumatoid arthritis (RA) are at increased risk for infections related to both the disease and its treatments. These include uncommonly reported infections due to histoplasmosis. METHODS: Medical record review of all patients with a diagnosis of RA who developed new histoplasmosis infection in an endemic region between Jan 1, 1998 and Jan 30, 2009 and who were seen at Mayo Clinic in Rochester, Minnesota was performed...
2011: BMC Infectious Diseases
https://www.readbyqxmd.com/read/21453973/recurrent-fever-of-unknown-origin-fuo-aseptic-meningitis-hepatosplenomegaly-pericarditis-and-a-double-quotidian-fever-due-to-juvenile-rheumatoid-arthritis-jra
#16
Burke A Cunha, Jean E Hage, Yelda Nouri
BACKGROUND: Fever of unknown origin (FUO) has been defined as a fever of ≥101°F that persists for 3 weeks or more. It is not readily diagnosed after 1 week of intensive in-hospital testing or after intensive outpatient or inpatient testing. Fevers of unknown origin may be caused by infectious diseases, malignancies, collagen vascular diseases, or a variety of miscellaneous disorders. The relative distribution of causes of FUOs is partly age-related. In the elderly, the preponderance of FUOs is attributable to neoplastic and infectious etiologies, whereas in children, collagen vascular diseases, neoplasms, and viral infectious disease predominate...
March 2012: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/20120426/atypical-presentation-of-histoplasmosis-in-a-patient-with-psoriasis-and-psoriatic-arthritis-on-infliximab-therapy
#17
Qurat ul Ain Kamili, Alan Menter
Infliximab is a chimeric monoclonal antibody to TNF-alpha which acts on both the soluble and transmembrane forms of TNF-alpha. It has been used successfully for the treatment of psoriasis and psoriatic arthritis, rheumatoid arthritis, Crohn's disease and ankylosing spondylitis either as monotherapy or in combination with drugs such as methotrexate. To date, over 20,440 patients with moderate-to-severe psoriasis have been treated with infliximab worldwide. Opportunistic infections and reactivation of underlying latent infections are an area of concern with the use of infliximab particularly when used in conjunction with other immunosuppresants...
January 2010: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/20032102/safety-tolerability-and-clinical-outcomes-after-intraarticular-injection-of-a-recombinant-adeno-associated-vector-containing-a-tumor-necrosis-factor-antagonist-gene-results-of-a-phase-1-2-study
#18
RANDOMIZED CONTROLLED TRIAL
Philip J Mease, Nathan Wei, Edward J Fudman, Alan J Kivitz, Joy Schechtman, Robert G Trapp, Kathryn F Hobbs, Maria Greenwald, Antony Hou, Stephen A Bookbinder, Galen E Graham, Craig W Wiesenhutter, Larry Willis, Eric M Ruderman, Joseph Z Forstot, Michael J Maricic, Kathryn H Dao, Charles H Pritchard, Darrell N Fiske, Francis X Burch, H Malin Prupas, Pervin Anklesaria, Alison E Heald
OBJECTIVE: To assess safety and clinical outcomes in patients with inflammatory arthritis after intraarticular (IA) injection of rAAV2-TNFR:Fc, a recombinant adeno-associated viral vector containing the human tumor necrosis factor (TNF) receptor-immunoglobulin (IgG1) Fc fusion (TNFR:Fc) gene. METHODS: In this phase 1/2 randomized study, adults with persistent moderate or severe inflammation in a target joint, being treated with or without systemic anti-TNF therapy, received a single IA injection of either rAAV2-TNFR:Fc (1 x 10(11), 1 x 10(12), or 1 x 10(13) DNase-resistant particles/ml joint volume) or placebo, followed by open-label rAAV2-TNFR:Fc 12-30 weeks later, depending on when the target joint met predetermined criteria for reinjection...
April 2010: Journal of Rheumatology
https://www.readbyqxmd.com/read/19674266/imported-histoplasmosis-two-distinct-profiles-in-travelers-and-immigrants
#19
Francesca F Norman, Pilar Martín-Dávila, Jesús Fortún, Fernando Dronda, Carmen Quereda, Aurora Sánchez-Sousa, Rogelio López-Vélez
BACKGROUND: Histoplasmosis is acquiring importance in nonendemic areas due to the increase in travel and immigration, being the most common systemic mycosis acquired by European travelers. Epidemiological studies show that the incidence of Histoplasma infection in these patients may be higher than previously believed and a wide clinical spectrum of disease may be observed. METHODS: Cases of histoplasmosis diagnosed at a Tropical Medicine Referral Unit in Madrid, Spain, during the period January 1996 to December 2006 were reviewed...
July 2009: Journal of Travel Medicine
https://www.readbyqxmd.com/read/19587341/investigation-of-the-cause-of-death-in-a-gene-therapy-trial
#20
Karen M Frank, D Kyle Hogarth, Jonathan L Miller, Saptarshi Mandal, Philip J Mease, R Jude Samulski, Glen A Weisgerber, John Hart
We present a case of disseminated histoplasmosis, complicated by retroperitoneal bleeding and leading to death, in a patient who was receiving systemic immunosuppressive therapy for rheumatoid arthritis and who was enrolled in a gene-therapy trial. This trial was designed to evaluate intraarticular delivery of a tumor necrosis factor alpha (TNF-alpha) antagonist, through an adeno-associated virus (AAV) type 2 delivery system, for inflammatory arthritis. The patient's receipt of concurrent anti-TNF-alpha therapy and other immunosuppressive therapy while she was living in an area where histoplasmosis was endemic was thought to be the most likely explanation for the infection; the evidence presented suggests that this fatal infection was unlikely to have been related to exposure to the agent administered in the gene-therapy trial...
July 9, 2009: New England Journal of Medicine
keyword
keyword
92566
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"