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JOURNAL ARTICLE
Juan David Puerta-Arias, Juan Pablo Isaza Agudelo, Tonny Williams Naranjo Preciado
Immunological assays based on the detection of circulating fungal biomarkers are helpful in clinical practice for diagnosing invasive fungal infections. Some of these targeting antigenic components are common to several different fungi. Histoplasmosis is a mycosis caused by the dimorphic fungus Histoplasma capsulatum , which in recent years has gained significant relevance due to the increase in the population susceptible to developing severe clinical forms, including those living with HIV/AIDS. Immunological tests that detect cell wall polysaccharide antigens are among the most used laboratory techniques for diagnosing this mycosis...
October 26, 2023: Microbiology Spectrum
#22
JOURNAL ARTICLE
Morgane Bourne-Watrin, Antoine Adenis, Gary Doppelt, Magaly Zappa, Loïc Epelboin, Mathieu Nacher, Jeanne Bigot, Kinan Drak Alsibai, Romain Blaizot, Denis Blanchet, Magalie Demar, Geneviève Guillot, Félix Djossou, Pierre Couppié
BACKGROUND: Histoplasmosis is mainly described as a disseminated disease in people living with HIV (PLHIV). Compared to historical descriptions in immunocompetent individuals, knowledge is lacking on the detailed clinical and radiological findings and outcomes of pulmonary histoplasmosis (PH). Overlooked or misdiagnosed with other AIDS-defining condition, prognostic of PLHIV may be at risk because of inappropriate care. METHODS: A retrospective multicentric study was conducted in PLHIV from French Guiana between January 1988 and October 2019...
October 15, 2023: Mycopathologia
#23
JOURNAL ARTICLE
Kishan Ghadiya, Robert Dunn, Gurpal Singh, Hobart Lai, Ralph Garcia-Pacheco
Histoplasma capsulatum is a dimorphic fungus found in certain parts of North, Central, and South America. Transmission is primarily through airborne inoculation from inhaled fungal microconidia. Histoplasmosis is typically a self-limited mycosis; however, in patients with immunodeficiency, disseminated disease can occur and may lead to high disease burden. This report studies a case of disseminated histoplasmosis in a patient newly diagnosed with human immunodeficiency virus. His presentation on admission was consistent with infectious pulmonary granulomatous disease, and further imaging and laboratory results showed evidence of multi-organ involvement...
2023: Journal of Investigative Medicine High Impact Case Reports
#24
Aadhar Oli, Shila Poudel, Abirodh Ranabhat
INTRODUCTION: Histoplasmosis is caused by the environmental fungus Histoplasma capsulatum . In immunocompromised patients, histoplasmosis can present as a disseminated infection that can involve the liver, lymph nodes, lungs, and adrenal glands. Disseminated histoplasmosis affecting the adrenal glands in an immunocompetent individual is a rare infection. CASE PRESENTATION: A 53-year-old male without HIV complained of weight loss of 15 kg in 6 months. Computed tomography (CT) scan of the abdomen was done, which showed bilateral adrenal gland hyperplasia with hepatosplenomegaly...
October 2023: Annals of Medicine and Surgery
#25
REVIEW
HeeEun Kang, John P Uy, Caroline C Ho, Heather B Blunt, Natalie B Riblet, Alessandro C Pasqualotto, Richard A Murphy
BACKGROUND: Evidence for efficacy of single, high-dose liposomal amphotericin B (LAmB) in HIV-associated cryptococcal meningitis and histoplasmosis is growing. No systematic review has examined the safety of this regimen across multiple studies. METHODS: We systematically searched Medline, Scopus, and the Cochrane Library from inception to April 2023 for studies reporting grade 3 and 4 adverse events (AEs) with single high-dose LAmB vs traditional amphotericin regimens for HIV-associated fungal infections...
October 2023: Open Forum Infectious Diseases
#26
Krishna Divyashree, Harpreet Singh, Mayur Parkhi, Indrani Karmakar, Man Updesh Singh Sachdeva, Vikas Suri, Ashish Bhalla
Hemophagocytic lymphohistiocytosis is usually considered a rapidly progressive fatal illness with poor outcomes. It is of two types: primary or familial and secondary. In patients with HIV, opportunistic infections are the secondary triggers of HLH. First line of management of infection associated HLH is treatment of the underlying infection. Here, we present a case of HLH in HIV infection due to disseminated histoplasmosis managed with liposomal amphotericin B, who required immunosuppressive therapy with intravenous immunoglobulin and dexamethasone due to nonresponse to primary therapy...
2023: Journal of Global Infectious Diseases
#27
JOURNAL ARTICLE
Panarat Noiperm, Pirun Saelue
OBJECTIVE: Bone marrow (BM) examination is valuable for identifying the cause of fever of unknown origin (FUO) in human immunodeficiency virus (HIV)-infected patients. Based on the outcomes of BM examination of patients with FUO, we aimed to develop a predictive model for identifying the factors that can increase the diagnostic yield of BM examination. DESIGN: For this retrospective cohort study, we enrolled HIV-infected patients, aged >15 years and diagnosed with FUO, at Songklanakarind Hospital in Southern Thailand, between January 2009 and December 2019...
October 4, 2023: AIDS
#28
JOURNAL ARTICLE
Carolina Rodríguez Laboccetta, María A Toscanini, Agustín Videla Garrido, Gladys B Posse, Paula Capece, Ruth M Valdez, Yone A Chacón, Daniel González Maglio, Alejandro D Nusblat, María L Cuestas
Among people living with HIV (PLHIV), progressive disseminated histoplasmosis (PDH) represents an important cause of mortality. Since antigen detection allows a rapid diagnosis and the instauration of a specific treatment this study aimed to evaluate the analytical performance of the Hcp100 dot blot, an in-house assay that detects the Histoplasma capsulatum 100-kilodalton antigen in urine and compare it with 2 commercially available assays the Histoplasma Urine Antigen Lateral Flow Assay (MVD-LFA) (MiraVista® Diagnostics) and the Clarus Histoplasma Galactomannan EIA (Clarus HGM) (IMMY)...
August 19, 2023: Diagnostic Microbiology and Infectious Disease
#29
REVIEW
Jorge Andrés Potosí, Yina Marcela Gutiérrez, Fabiola Eugenia González
Histoplasmosis is an endemic mycosis in Colombia. Here we present two cases in the Cauca department, to indicate the clinical impact of histoplasmosis delayed diagnosis and treatment when its epidemiology is unknown. Informed consent was requested to review patients’ medical records and case report publication. The first case was a patient diagnosed with human immunodeficiency virus and generalized presence of skin lesions. Initially, these lesions were diagnosed as herpes, but a postmortem diagnosis confirmed histoplasmosis through fungal cultures of tissues from the skin lesions...
August 31, 2023: Biomédica: Revista del Instituto Nacional de Salud
#30
Mohammad Usman, Ashley C Calise, Arsh N Patel, Austin Huang, Laurence Stolzenberg, Mohammad Ibrahim, Navneet Kaur
Histoplasmosis is a fungal infection that, if left untreated, can result in very serious health outcomes, especially in patient populations that are immunocompromised. While the manifestations of the disease are very diverse and highly dependent on the individual health conditions of the patient, in severe cases, it can lead to serious pneumonia, acute respiratory distress syndrome, and death if rapid medical intervention is not performed. Here, we present the case of a patient with acquired immunodeficiency syndrome who suffered from histoplasmosis pneumonia with suspected superimposed Pneumocystis pneumonia...
August 2023: Curēus
#31
Regina Maria Raffaele, Mario Eduardo Baldo, Mariana Bernardoni Grimm, Luana Campos, Luiz Felipe Palma
BACKGROUND: Secondary infections of leishmaniasis and histoplasmosis in patients with advanced HIV are still a concern in low- and middle-income countries. The most common drugs for the treatment of both infections may be problematic mainly due to their toxicity. AIM AND CASE REPORT: The present study aimed to report a case in which a concurrent oral manifestation of leishmaniasis and histoplasmosis in a hospitalized patient with HIV was managed with a combination of photobiomodulation therapy (PBMT) and antimicrobial photodynamic therapy (aPDT) as an adjuvant treatment...
December 2023: Photodiagnosis and Photodynamic Therapy
#32
Erika Reina-Bautista, Omar Esteban Valencia-Ledezma, María Guadalupe Frías-De-León, Gustavo Acosta-Altamirano, Carlos Alberto Castro-Fuentes
HIV-associated hemophagocytic lymphohistiocytosis (HLH) is mainly due to infections caused by viruses, fungi, and, to a lesser extent, bacteria, often with fatal results. Case presentation: A 15-year-old pediatric patient from another institution was admitted to our hospital with a fever of unknown origin (FUO). Clinical analysis and laboratory studies diagnosed HIV infection. The approach to an FUO in a patient with AIDS is much more complex due to the search for common etiologies and opportunistic infections...
August 8, 2023: Pathogens
#33
REVIEW
Kenneth Villareal, Austin Price, Alessandro C Pasqualotto, Nathan C Bahr
Histoplasmosis is caused by Histoplasma capsulatum and, although endemic in large parts of the world, is often underrecognized in many locations. In addition to underrecognition, inadequate availability of diagnostic tests is a major contributor to poor outcomes in disseminated disease in people with HIV. For those with advanced HIV and disseminated disease, antibody testing is less useful. Culture and histopathology can be useful in this situation, but each has limitations, including variable sensitivity by site and, in the case of culture, the need for a biosafety level three laboratory and a long period of growth...
July 28, 2023: Journal of Fungi (Basel, Switzerland)
#34
JOURNAL ARTICLE
Radha Rajasingham, Narda Medina, Gabriel T Mousquer, Diego H Caceres, Alexander Jordan, Mathieu Nacher, Diego R Falci, Ayanna Sebro, Alessandro C Pasqualotto, Omar Sued, Tom Chiller, Freddy Perez
Histoplasma antigen can be detected in people with advanced HIV disease (AHD), allowing for early and accurate diagnosis of histoplasmosis. The aim of this analysis was to assess the cost-effectiveness of routine histoplasmosis screening using antigen detection, among people with AHD. We developed a decision analytic model to evaluate Histoplasma antigen screening among people with AHD. The model estimated the costs, effectiveness, and cost-effectiveness of routine screening for Histoplasma antigen compared to the current practice of no routine Histoplasma antigen screening...
2023: PLOS Glob Public Health
#35
Luca Pipitò, Alice Annalisa Medaglia, Marcello Trizzino, Alessandro Mancuso, Bianca Catania, Salvatrice Mancuso, Cinzia Calà, Ada Maria Florena, Antonio Cascio
Here, we describe the case of a naïve HIV late presenter female African patient with progressive disseminated histoplasmosis and a severe life-threatening clinical picture in a non-endemic area. She had not visited Africa in the past decade. She developed a reactive hemophagocytic lymphohistiocytosis and an acute psychiatric disorder. Histoplasmosis was diagnosed after two bone marrow biopsies. Therapy with liposomal amphotericin B resulted in rapid and progressive improvements in blood examinations and clinical conditions, including the disappearance of psychiatric disorders...
August 2023: Heliyon
#36
JOURNAL ARTICLE
Preethiya Sekar, Elizabeth Nalintya, Richard Kwizera, Claudine Mukashyaka, Godfrey Niyonzima, Loryndah Olive Namakula, Patricia Nerima, Ann Fieberg, Biyue Dai, Jayne Ellis, David R Boulware, David B Meya, Nathan C Bahr, Radha Rajasingham
In sub-Saharan Africa, an estimated 25% of people with HIV present with advanced HIV and are at high risk of opportunistic infections. Whereas histoplasmosis has occasionally been seen in Uganda, the understanding of the local risk of acute infection is limited. We sought to determine the prevalence of Histoplasma antigenuria using an enzyme immunoassay (EIA, clarus Histoplasma GM EIA, IMMY; Norman, OK, USA) in a cohort of outpatients with advanced HIV disease in Kampala, Uganda. Among the persons with positive urine Histoplasma antigen tests, we assessed their clinical presentation and outcomes...
July 18, 2023: Journal of Fungi (Basel, Switzerland)
#37
JOURNAL ARTICLE
Luisa F López, Ángela M Tobón, Diego H Cáceres, Tom Chiller, Anastasia P Litvintseva, Lalitha Gade, Ángel González, Beatriz L Gómez
Histoplasmosis is a fungal infection caused by the thermally dimorphic fungus Histoplasma capsulatum. This infection causes significant morbidity and mortality in people living with HIV/AIDS, especially in countries with limited resources. Currently used diagnostic tests rely on culture and serology but with some limitations. No molecular assays are commercially available and the results from different reports have been variable. We aimed to evaluate quantitative real-time PCR (qPCR) targeting three protein-coding genes of Histoplasma capsulatum (100-kDa, H and M antigens) for detection of this fungus in formalin-fixed paraffin-embedded (FFPE) samples from patients with proven histoplasmosis...
June 25, 2023: Journal of Fungi (Basel, Switzerland)
#38
REVIEW
Zeinab Mohseni Afshar, Azadeh Goodarzi, Seyed Naser Emadi, Ronak Miladi, Safoura Shakoei, Alireza Janbakhsh, Zeinab Aryanian, Parvaneh Hatami
Dermatological disorders are among the most prevalent manifestations of HIV infection/acquired immunodeficiency syndrome (AIDS). In this review, we aimed to characterize the various dermatologic presentations among HIV-infected patients with a detailed categorization of the mucocutaneous signs and symptoms, their etiopathogenic factors, and clinical management. In fact, cutaneous manifestations of HIV are quite various, ranging from AIDS-specific skin eruptions (xerosis, pruritic papular eruptions, eosinophilic folliculitis, and acne), opportunistic infections (herpes simplex, molluscum contagiosum, cutaneous leishmaniasis, bacillary angiomatosis, disseminated histoplasmosis, disseminated cryptococcosis, and zoster) to AIDS-related malignancies (Kaposi's sarcoma, lymphoma, and nonmelanoma skin cancers) and antiretroviral therapy (ART)-associated drug eruptions...
2023: International Journal of Microbiology
#39
JOURNAL ARTICLE
Loïc Epelboin, Philippe Abboud, Karim Abdelmoumen, Frédégonde About, Antoine Adenis, Théo Blaise, Romain Blaizot, Timothée Bonifay, Morgane Bourne-Watrin, Mathilde Boutrou, Gabriel Carles, Pierre-Yves Carlier, Jean-François Carod, Luisiane Carvalho, Pierre Couppié, Bertrand De Toffol, François Delon, Magalie Demar, Justin Destoop, Maylis Douine, Jean-Pierre Droz, Narcisse Elenga, Antoine Enfissi, Yves-Kénol Franck, Alexis Fremery, Mélanie Gaillet, Hatem Kallel, Arsène Amadouhé Kpangon, Anne Lavergne, Paul Le Turnier, Lucas Maisonobe, Céline Michaud, Rémi Mutricy, Mathieu Nacher, Richard Naldjinan-Kodbaye, Margot Oberlis, Guillaume Odonne, Lindsay Osei, Jean Pujo, Sébastien Rabier, Brigitte Roman-Laverdure, Cyril Rousseau, Dominique Rousset, Nadia Sabbah, Vincent Sainte-Rose, Roxane Schaub, Karamba Sylla, Marc-Alexandre Tareau, Victor Tertre, Camille Thorey, Véronique Vialette, Gaëlle Walter, Magaly Zappa, Félix Djossou, Nicolas Vignier
Source of many myths, French Guiana represents an exceptional territory due to the richness of its biodiversity and the variety of its communities. The only European territory in Amazonia, surrounded by the Brazilian giant and the little-known Suriname, Ariane 6 rockets are launched from Kourou while 50% of the population lives below the poverty line. This paradoxical situation is a source of health problems specific to this territory, whether they be infectious diseases with unknown germs, intoxications or chronic pathologies...
March 31, 2023: Med Trop Sante Int
#40
(no author information available yet)
[This corrects the article doi: 10.1590/S1678-9946202365028].
June 23, 2023: Revista do Instituto de Medicina Tropical de São Paulo
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