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Hiv histoplasmosis

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https://www.readbyqxmd.com/read/29862155/progressive-disseminated-histoplasmosis-in-an-immunocompetent-adult-a-case-report
#1
Nitesh Kumar Bauddha, Ranveer Singh Jadon, Saikat Mondal, N K Vikram, Rita Sood
Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum which occurs endemically in some parts of the world like North and Central America particularly in Mississippi and Ohio River valleys, but is uncommon in India. Progressive disseminated form of histoplasmosis (PDH) usually occurs in the immune-compromised hosts especially in HIV positive population. In PDH any organ can be involved like lung, liver, spleen, brain, adrenals etc . Involvement of oral cavity and buccal mucosa in PDH is common but pharyngeal involvement is rare...
May 2018: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29768547/clinical-outcomes-and-risk-factors-for-death-from-disseminated-histoplasmosis-in-patients-with-aids-who-visited-a-high-complexity-hospital-in-campo-grande-ms-brazil
#2
Barbara Cristina Scarcelli Boigues, Anamaria Mello Miranda Paniago, Gláucia Moreira Espíndola Lima, Maina de Oliveira Nunes, Silvia Naomi de Oliveira Uehara
INTRODUCTION: Disseminated histoplasmosis (DH) is a systemic mycosis caused by Histoplasma capsulatum (H. capsulatum) and is characterized by progressive and fatal evolution in immunocompromised patients. Moreover, it is considered an AIDS-defining disease. METHODS: We performed an observational, analytical, retrospective study to identify the clinical outcomes and risk factors for death from DH in patients with AIDS at an infectious diseases service facility in Brazil between September 2011 and July 2016...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29742119/prior-subclinical-histoplasmosis-revealed-in-nigeria-using-histoplasmin-skin-testing
#3
Rita O Oladele, Conchita Toriello, Folasade T Ogunsola, Olusola O Ayanlowo, Philip Foden, Adetona S Fayemiwo, Iriagbonse I Osaigbovo, Anthony A Iwuafor, Shuwaram Shettima, Halimat A Ekundayo, Malcolm D Richardson, David W Denning
OBJECTIVES: Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin. DESIGN: A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria. METHODS: We recruited both healthy non-HIV and HIV-positive adults with CD4 count ≥ 350 cells/mm3 regardless of their ART status from March to May 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29601494/the-burden-of-serious-fungal-infections-in-cameroon
#4
Christine E Mandengue, David W Denning
Fungal infections are frequent in Cameroon, and invasive fungal infections are sometimes detected, usually in HIV-infected patients. For these reasons, we have estimated the burden of fungal infections. Using published literature and population estimates for the at-risk group, we used deterministic modelling to derive national incidence and prevalence estimates for the most serious fungal diseases. HIV infection is common and an estimated 120,000 have CD4 counts <200 × 10⁶/mL and commonly present with opportunistic infection...
March 30, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29592837/a-proposal-of-antifungal-epidemiological-cut-off-values-against-histoplasma-capsulatum-var-capsulatum-based-on-the-susceptibility-of-isolates-from-hiv-infected-patients-with-disseminated-histoplasmosis-in-northeastern-brazil
#5
Raimunda Sâmia Nogueira Brilhante, Glaucia Morgana de Melo Guedes, Maria Lucilene Queiroz da Silva, Débora Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
Epidemiological cutoff values (ECV) have been used as a tool to detect the acquisition of resistance mechanisms to antifungal drugs. In this context, the objective of this study was to determine the epidemiological cutoff values for classic antifungals against Histoplasma capsulatum var. capsulatum isolates from HIV-infected patients with the diagnosis of disseminated histoplasmosis. Initially, the minimum inhibitory concentrations (MIC) for amphotericin B, itraconazole, fluconazole, voriconazole and caspofungin against 138 isolates of H...
March 25, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29588907/disseminated-toxoplasmosis-in-a-patient-with-advanced-acquired-immunodeficiency-syndrome
#6
Ricardo Garcia Pastorello, Anderson da Costa Lino Costa, Marcio Valente Yamada Sawamura, Antonio Carlos Nicodemo, Amaro Nunes Duarte-Neto
Extracerebral toxoplasmosis, with pulmonary involvement and shock, is a rare form of toxoplasmosis in patients with advanced AIDS. It can mimic pneumocystosis, histoplasmosis, and disseminated tuberculosis, and should be considered in the differential diagnosis of causes of respiratory failure and fulminant disease in this group of individuals, especially in areas where the Toxoplasma gondii infection is highly prevalent and in those without proper use of antimicrobial prophylaxis. We report the case of a 46-year-old male patient who presented to the emergency department with uremia, requiring urgent dialysis...
January 2018: Autopsy & case reports
https://www.readbyqxmd.com/read/29563205/multicenter-validation-of-commercial-antigenuria-reagents-to-diagnose-progressive-disseminated-histoplasmosis-in-people-living-with-hiv-aids-in-two-latin-american-countries
#7
Diego H Cáceres, Blanca E Samayoa, Narda G Medina, Angela M Tobón, Brenda J Guzmán, Danicela Mercado, Angela Restrepo, Tom Chiller, Eduardo E Arathoon, Beatriz L Gómez
Histoplasmosis is an important cause of mortality in patients with AIDS, especially in countries with limited access to antiretroviral therapies and diagnostic tests. However, many disseminated infections in Latin America go undiagnosed. A simple, rapid method to detect Histoplasma capsulatum infection in regions where histoplasmosis is endemic would dramatically decrease the time to diagnosis and treatment, reducing morbidity and mortality. The aim of this study was to validate a commercial monoclonal Histoplasma galactomannan (HGM) enzyme-linked immunosorbent assay (Immuno-Mycologics [IMMY], Norman, OK, USA) in two cohorts of people living with HIV/AIDS (PLHIV)...
June 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#8
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29535767/gastrointestinal-histoplasmosis-presenting-as-an-acute-abdomen-with-jejunal-perforation
#9
Bryan R Anderson, Jaron Marriott, Chinthaka Bulathsinghala, Humayun Anjum, Salim Surani
Introduction: Gastrointestinal histoplasmosis (GH) is a well-described albeit uncommon disease. It is found almost exclusively in the immunocompromised host, especially those with untreated HIV and low CD4 counts. Presentation with intestinal perforation is seen mostly commonly in the colon. We present a patient with jejunal perforation, and there have been only 3 previous cases reported in the literature. Case: A 39-year-old male with known, untreated HIV presented to the ED with an acute abdomen after experiencing worsening intermittent abdominal pain for 2 months before that was associated with nausea, vomiting, diarrhea, and weight loss...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29519625/disseminated-histoplasmosis-diagnosed-in-the-bone-marrow-of-an-hiv-infected-patient-first-case-imported-in-tunisia
#10
N Fakhfakh, R Abdelmlak, S Aissa, A Kallel, Y Boudawara, S Bel Hadj, N Ben Romdhane, H Touiri Ben Aissa, K Kallel
Histoplasmosis is a fungal infection caused by a dimorphic fungus, Histoplasma capsulatum. We report a first case of disseminated histoplasmosis in a 34-year-old woman, infected with human immunodeficiency virus (HIV), originating from Ivory Coast and living in Tunisia for 4 years. She was complaining from fever, chronic diarrhoea and pancytopenia. The Histoplasma capsulatum var. capsulatum was identified by direct microscopic examination of the bone marrow. She was treated by Amphotericin B, relayed by itraconazole...
March 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29515346/ileum-histoplasmosis-mimicking-intestinal-tuberculosis-and-crohn-s-disease
#11
Xin-Bo Ai, Zhen-Jiang Wang, Qi-Chao Dong, Xu Lin, Yu-Ping Chen, Fei-Yue Gong, Hui Liang
Gastrointestinal histoplasmosis (GIH) without pulmonary and bone marrow involvement is very rare worldwide. It can be misdiagnosed as intestinal tuberculosis or Crohn's disease. There are just few case reports of GIH in patients with a positive HIV antibody test. Here, we report a patient who presented to our hospital with repeated intestinal obstruction. The suspicious diagnosis was intestinal tuberculosis or Crohn's disease due to unspecific clinical manifestations and radiologic images. Our patient's HIV antibody test was negative...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29454844/the-epidemiology-of-febrile-illness-in-sub-saharan-africa-implications-for-diagnosis-and-management
#12
REVIEW
M J Maze, Q Bassat, N A Feasey, I Mandomando, P Musicha, J A Crump
BACKGROUND: Fever is among the most common symptoms of people living in Africa, and clinicians are challenged by the similar clinical features of a wide spectrum of potential aetiologies. AIM: To summarize recent studies of fever aetiology in sub-Saharan Africa focusing on causes other than malaria. SOURCES: A narrative literature review by searching the MEDLINE database, and recent conference abstracts. CONTENT: Studies of multiple potential causes of fever are scarce, and for many participants the infecting organism remains unidentified, or multiple co-infecting microorganisms are identified, and establishing causation is challenging...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29447170/imported-endemic-mycoses-in-spain-evolution-of-hospitalized-cases-clinical-characteristics-and-correlation-with-migratory-movements-1997-2014
#13
Daniel Molina-Morant, Adrián Sánchez-Montalvá, Fernando Salvador, Augusto Sao-Avilés, Israel Molina
Endemic mycoses are systemic fungal infections. Histoplasmosis is endemic in all temperate areas of the world; coccidioidomycosis and paracoccidioidomycosis are only present in the American continent. These pathogens are not present in Spain, but in the last years there has been an increase of reported cases due to migration and temporary movements. We obtained from the Spanish hospitals records clinical and demographic data of all hospitalized cases between 1997 and 2014. There were 286 cases of histoplasmosis, 94 of Coccidioidomycosis and 25 of paracoccidioidomycosis...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29433397/hemophagocytic-lymphohistiocytosis-in-an-hiv-positive-patient-with-concomitant-disseminated-histoplasmosis
#14
Nisha Loganantharaj, Brianna Oliver, Taylor Smith, Rachna Jetly, Lee Engel, Shane Sanne
A 46-year-old Dominican man, known to have HIV, presented with constitutional symptoms of two week's duration. The patient was found to have cytopenias, significantly elevated ferritin level and lymphadenopathy. Biopsies and laboratory studies met the criteria for hemophagocytic lymphohistiocytosis (HLH). A concomitant diagnosis of histoplasmosis was confirmed as the trigger for HLH and treatment resulted in clinical improvement and resolution of symptoms.
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29429549/mucocutaneous-manifestations-of-infection-by-histoplasma-capsulatum-in-hiv-negative-immunosuppressed-patients
#15
L V Gómez-Santana, A C Torre, B A Hernández, V I Volonteri, B Laura, R Luis-Galimberti
Histoplasmosis is a systemic mycosis caused by the dimorphous fungus Histoplasma capsulatum (H. capsulatum). The fungus enters the body through the respiratory tract in the form of microconidia, which are transformed into intracellular yeast-like structures in the lungs before disseminating hematogenously. Primary infection is usually asymptomatic and self-resolving. Some patients develop severe disease with acute or chronic respiratory involvement. Immunosuppressed patients, mainly those with altered cellular immunity, may have disseminated disease with variable mucocutaneous involvement characterized by papules, nodules, gummas, or ulcers with a granulomatous base...
May 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29379706/histoplasmosis-an-oral-malignancy-like-clinical-picture
#16
Tomasz Chroboczek, Julie Dufour, Alain Renaux, Christine Aznar, Magalie Demar, Pierre Couppie, Antoine Adenis
HIV-associated histoplasmosis is mainly misdiagnosed for granulomatous diseases, such as tuberculosis. Nonetheless, malignancy-like lesions have been reported sporadically in HIV-infected patients. Although the main reported lesions are erosive or ulcerated, here a rare case of oral tumor is reported. This case raises the awareness of this presentation, and the importance of accurate identification in the laboratory. Performing systematic specific stains for fungal elements and culture on tissue samples ensures accurate differential diagnosis...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29374650/concurrent-pneumocystis-jirovecii-and-pulmonary-histoplasmosis-in-an-undiagnosed-hiv-patient
#17
Ahsan Wahab, Siddique Chaudhary, Mahin Khan, Susan Jane Smith
Concurrent Pneumocystis jirovecii (PJ) and pulmonary histoplasmosis (PHP) are rare in a single HIV individual. We present a challenging case of concomitant PJ and PHP in a young HIV individual. A 44-year-old man presented to the emergency department with progressive pulmonary symptoms. He was hypoxic with bilateral pulmonary opacities on chest radiograph. CT of the chest showed a geographical pattern of ground-glass attenuation. He started receiving intravenous antibiotics in addition to oral Bactrim for suspected PJ...
January 26, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29371573/global-and-multi-national-prevalence-of-fungal-diseases-estimate-precision
#18
REVIEW
Felix Bongomin, Sara Gago, Rita O Oladele, David W Denning
Fungal diseases kill more than 1.5 million and affect over a billion people. However, they are still a neglected topic by public health authorities even though most deaths from fungal diseases are avoidable. Serious fungal infections occur as a consequence of other health problems including asthma, AIDS, cancer, organ transplantation and corticosteroid therapies. Early accurate diagnosis allows prompt antifungal therapy; however this is often delayed or unavailable leading to death, serious chronic illness or blindness...
October 18, 2017: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29348388/disseminated-histoplasmosis-in-an-indonesian-hiv-positive-patient-a-case-diagnosed-by-fine-needle-aspiration-cytology
#19
Nungki Anggorowati, Rita C Sulistyaningsih, Ahmad Ghozali, Yanri W Subronto
A 30-year-old Javanese-Indonesian man was admitted with complaints of 3 months persistent fever, weight loss, and fatigue. He had never known his past history of unprotected HIV until the admission. His only risk factor is unsafe sex. The patient seemed well nourished. Physical examination revealed blood pressure 100/60 mmHg, pulse 100 beats per minute, respiratory rate 20 times per minute, and temperature 38.8°C. Multiple cervical and inguinal lymphadenopathies were also found. Electrocardiogram showed anterolateral ischemic finding, whereas chest X-ray were normal...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29346384/histoplasmosis-in-africa-an-emerging-or-a-neglected-disease
#20
REVIEW
Rita O Oladele, Olusola O Ayanlowo, Malcolm D Richardson, David W Denning
Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades (1952-2017), 470 cases of histoplasmosis have been reported. HIV-infected patients accounted for 38% (178) of the cases. West Africa had the highest number of recorded cases with 179; the majority (162 cases) were caused by Histoplasma capsulatum var. dubuosii (Hcd). From the Southern African region, 150 cases have been reported, and the majority (119) were caused by H...
January 2018: PLoS Neglected Tropical Diseases
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