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Dermatophytosis

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https://www.readbyqxmd.com/read/29141535/sln-and-nlc-encapsulating-antifungal-agents-skin-drug-delivery-and-their-unexplored-potential-for-treating-onychomycosis
#1
Tais Gratieri, Anna Paula Krawczyk-Santos, Priscila Bianca Rodrigues da Rocha, Marcilio Cunha-Filho, Guilherme Martins Gelfuso, Ricardo Neves Marreto, Stephania Fleury Taveira
BACKGROUND: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially for dermatophytosis treatments. They can accumulate in skin appendages and release drugs in a controlled manner and also increase skin moisture, due to the formation of an occlusive film. Since moisture heavily influences nail and skin permeability, these systems seem to pose great potential for antifungal drug delivery. METHODS: We therefore compare skin and nail physiopathological structure and discuss the potential use of lipid nanoparticles in managing skin and nail mycoses, highlighting their unexplored use in onychomycosis...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29094463/severe-dermatophytosis-in-solid-organ-transplant-recipients-a-french-retrospective-series-and-literature-review
#2
Claire Rouzaud, Olivier Chosidow, Anabelle Brocard, Sylvie Fraitag, Anne Scemla, Dany Anglicheau, Jean-David Bouaziz, Nicolas Dupin, Marie-Elisabeth Bougnoux, Roderick Hay, Olivier Lortholary, Fanny Lanternier
OBJECTIVE: Severe dermatophytosis is described in immunocompromised patients with defective cellular immunity. We report here a large series and a literature review of severe dermatophytosis in solid organ transplant (SOT) recipients. METHOD: The data main source was a national French retrospective study of severe dermatophytosis in SOT recipients between 2010 and 2016. Inclusion criteria were the presence of dermatophytes in skin culture and one severity criteria: dermal invasion by dermatophytes (invasive dermatophytosis) or involvement of at least two body sites or >10% of body surface area (extensive dermatophytosis) RESULTS: Twelve patients were included (8 men, median age of 56 years [range: 33-71])...
November 2, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29072357/piper-regnellii-extract-biopolymer-based-microparticles-production-characterization-and-antifungal-activity
#3
Lara Zampar Serra Brambilla, Eliana Harue Endo, Diógenes Aparício Garcia Cortez, Marli Miriam de Souza Lima, Benedito Prado Dias Filho
AIMS: This study aims to improve characteristics of Piper regnellii extract to make it applicable in formulations to treat dermatophytosis, also known as ringworm. METHODS AND RESULTS: Microparticles were produced by spray-drying with gelatin, alginate and chitosan as encapsulating agents, characterized by scanning electron microscopy, encapsulation efficiency, thermal analyses, X-ray diffraction, and tested against Trichophyton rubrum by broth microdilution. Produced microparticles had a mean diameter less than 2 μm, an increase in stability and release of the extract and good results for encapsulation efficiency, being 85...
October 26, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29067631/dermatomycoses-due-to-nannizzia-praecox-formerly-microsporum-praecox-in-germany-case-reports-and-review-of-the-literature
#4
REVIEW
Silke Uhrlaß, Peter Mayser, Roman Schwarz, Daniela Koch, Constanze Krüger, Irene Korfmann, Pietro Nenoff
Nannizzia praecox, formerly known as Microsporum praecox, is a geophilic dermatophyte. Up to now 31 cases of human tinea have been reported in the literature, most of them with an inflammatory course. Three recent cases diagnosed in Germany within 1 year suggest that the fungus might be a more common cause of human dermatophytosis than reported so far. This might be based on the fact that N. praecox is often found in an equine environment and that horse riding is becoming more popular recently.
October 24, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28992062/epidemiology-of-human-dermatophytoses-in-africa
#5
Oumar Coulibaly, Coralie L'Ollivier, Renaud Piarroux, Stéphane Ranque
In this critical literature review, we summarize the epidemiological trends of dermatophytoses reported in Africa. Our findings clearly emphasize the heavy burden of dermatophytosis in Africa. Tinea capitis is the primary clinical presentation of dermatophytosis in African children throughout the entire African continent. The disease affects more than 20% of school-age children in West Africa, while the prevalence ranges from 10% to more than 70% in other regions of Africa. In African adults, the presence of tinea corporis is the most frequent indicator of dermatophytosis...
July 28, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28979861/treatment-of-dermatophytosis-in-elderly-children-and-pregnant-women
#6
REVIEW
Subuhi Kaul, Savita Yadav, Sunil Dogra
Dermatophytic infection of the skin and its appendages is a common occurrence. Though usually straightforward, treatment of dermatophytosis becomes notably challenging in certain population groups - pregnant women, children, and elderly. Treatment with topical azoles/allylamines alone is effective in limited cutaneous disease in all three groups. Terbinafine is the preferred oral agent in elderly population for treatment of extensive cutaneous disease and onychomycosis due to its lack of cardiac complications and lower propensity for drug interactions...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28960268/mucocutaneous-manifestations-in-human-immunodeficiency-virus-hiv-infected-patients-in-nouakchott-mauritania
#7
Boushab M Boushab, Fatim-Zahra Malick Fall, Taleb K Ould Cheikh Mohamed Vadel, Mohamed L Ould Cheikh Melaïnine, Mohamed V Maazouz, Mamoudou Savadogo, Leonardo K Basco
BACKGROUND: Mucocutaneous manifestations are one of the first clinical signs in patients infected with human immunodeficiency virus (HIV). To the best of our knowledge, there has been no previous study describing dermatologic manifestations in Mauritanians infected with HIV. The aim of the present study was to determine the profiles of mucocutaneous manifestations in relation to CD4 T cell count in HIV-positive Mauritanian patients. METHODS: A total of 86 adult patients aged > 18 years old attending the Ambulatory Treatment Center of the National Hospital of Nouakchott, Mauritania, with newly diagnosed HIV and who were not under antiretroviral treatment were included in the study in 2015...
September 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28959790/proteolytic-activity-and-cooperative-hemolytic-effect-of-dermatophytes-with-different-species-of-bacteria
#8
K Pakshir, T Mohamadi, H Khodadadi, M Motamedifar, K Zomorodian, S Alipour, M Motamedi
BACKGROUND AND PURPOSE: Globally, dermatophytes are the most common filamentous group of fungi causing cutaneous mycoses. Dermatophytes were shown to secrete a multitude of enzymes that play a role in their pathogenesis. There is limited data on co-hemolytic (CAMP-like) effect of different bacterial species on dermatophyte species. In this study, we sought to the evaluate exoenzyme activity and co-hemolytic effect of four bacteria on clinical dermatophytes isolated from patients in Shiraz, Iran...
December 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28947778/an-invertebrate-infection-model-for-evaluating-anti-fungal-agents-against-dermatophytosis
#9
Masaki Ishii, Yasuhiko Matsumoto, Tsuyoshi Yamada, Shigeru Abe, Kazuhisa Sekimizu
Animal models of pathogenic infection are needed to evaluate candidate compounds for the development of anti-infectious drugs. Dermatophytes are pathogenic fungi that cause several infectious diseases. We established a silkworm dermatophyte infection model to evaluate anti-fungal drugs. Injection of conidia of the dermatophyte Arthroderma vanbreuseghemii into silkworms was lethal. A. vanbreuseghemii conidia germinated in liquid culture were more potent against silkworms than non-germinated conidia. Germinated conidia of other dermatophytes, Arthroderma benhamiae, Trichophyton rubrum, and Microsporum canis, also killed silkworms...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28936991/intracutaneous-pharmacokinetics-of-oral-antifungals-and-their-relevance-in-recalcitrant-cutaneous-dermatophytosis-time-to-revisit-basics
#10
Kabir Sardana, Pooja Arora, Khushbu Mahajan
No abstract text is available yet for this article.
September 21, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28920535/evaluation-of-incubation-time-for-microsporum-canis-dermatophyte-cultures
#11
Rebecca Stuntebeck, Karen A Moriello, Maria Verbrugge
Objectives The goal of this study was to determine how frequently Microsporum canis was isolated after 1, 2 and 3 weeks of incubation on dermatophyte culture medium either from untreated cats or cats during treatment. Methods This was an observational retrospective study. Toothbrush fungal culture results were examined from two data pools: untreated cats with suspect skin lesions and weekly fungal cultures from cats being treated for dermatophytosis. Results Results from 13,772 fungal cultures were reviewed and 2876 (20...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28889931/isolation-and-antifungal-activity-evaluation-of-satureja%C3%A2-khuzestanica-jamzad-extract-against-some-clinically-important-dermatophytes
#12
B Sadeghi-Nejad, A Rezaei-Matehkolaei, S Yusef Naanaie
Among the fungi, dermatophytes are the major cause of spectrum of superficial mycoses medically known as dermatophytosis (tinea) in human and animal. Treatment of these infections has still remained difficult. The aim of this survey was to evaluate in vitro anti-dermatophytic activity of ethanolic extract (EtOH) from Satureja khuzestanica leaf (SKLE) against some clinically important dermatophyte species from the genera of Trichophyton, Microsporum and Epidermophyton. Minimal inhibition concentration (MIC) of SKLE was tested against 14 dermatophyte strains of 5 species by using agar dilution method...
September 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28833730/use-of-a-commercial-qpcr-assay-in-52-high-risk-shelter-cats-for-disease-identification-of-dermatophytosis-and-mycological-cure
#13
Karen A Moriello, Christian M Leutenegger
BACKGROUND: qPCR is used to test for dermatophytosis. OBJECTIVES: To determine the clinical usefulness of a commercial qPCR for confirming dermatophytosis in lesional cats, and the clinical usefulness of the qPCR Microsporum spp. and/or M. canis assay for confirming mycological cure. ANIMALS: Fifty two shelter cats with skin lesions. METHODS: qPCR testing of toothbrush fungal culture samples of lesions. RESULTS: qPCR and fungal culture (FC) matched in 49 of 52 cats...
August 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28831770/distribution-of-species-of-dermatophyte-among-patients-at-a-dermatology-centre-of-nghean-province-vietnam-2015-2016
#14
Ngoc-Anh Do, Thai-Dung Nguyen, Khac-Luc Nguyen, Tran-Anh Le
INTRODUCTION: Vietnam is a tropical country so fungal diseases including dermatophytosis may be prevalent, but epidemiological profiles of agents responsible for the infection have rarely been reported. OBJECTIVE: To find out the distribution of dermatophytes among patients living in a central province of Vietnam. METHODS: We examined dermatophyte infections in patients with lesions suspected of dermatophytosis referred to the Nghean provincial leprosy and dermatology centre from August 2015 to August 2016...
December 2017: Mycopathologia
https://www.readbyqxmd.com/read/28802670/chemoselective-fluorination-and-chemoinformatic-analysis-of-griseofulvin-natural-vs-fluorinated-fungal-metabolites
#15
Noemi D Paguigan, Mohammed H Al-Huniti, Huzefa A Raja, Austin Czarnecki, Joanna E Burdette, Mariana González-Medina, José L Medina-Franco, Stephen J Polyak, Cedric J Pearce, Mitchell P Croatt, Nicholas H Oberlies
Griseofulvin is a fungal metabolite and antifungal drug used for the treatment of dermatophytosis in both humans and animals. Recently, griseofulvin and its analogues have attracted renewed attention due to reports of their potential anticancer effects. In this study griseofulvin (1) and related analogues (2-6, with 4 being new to literature) were isolated from Xylaria cubensis. Six fluorinated analogues (7-12) were synthesized, each in a single step using the isolated natural products and Selectflour, so as to examine the effects of fluorine incorporation on the bioactivities of this structural class...
October 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28794551/efficacy-and-safety-of-terbinafine-500-mg-once-daily-in-patients-with-dermatophytosis
#16
P Ravindra Babu, A J S Pravin, Gaurav Deshmukh, Dhiraj Dhoot, Aniket Samant, Bhavesh Kotak
INTRODUCTION: Dermatophytosis are the most common fungal infections globally. Terbinafine is considered to have good potency against dermatophytes, but resistance to terbinafine is on the rise. OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of terbinafine 500 mg given once daily in treatment of patients with superficial dermatophytosis. MATERIALS AND METHODS: It was a retrospective questionnaire-based survey...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28757272/epidemiology-of-dermatomycoses-in-kerman-province-southeast-of-iran-a-10-years-retrospective-study-2004-2014
#17
Samira Salari, Seyyed Amin Ayatollahi Mousavi, Sanaz Hadizadeh, Alireza Izadi
OBJECTIVES: Superficial and cutaneous fungal infections (SCFIs) are an important public health problem and are common in tropical and subtropical countries. Pityriasis versicolor, dermatophytosis, erythrasma, onychomycosis, and otomycosis are the major diseases associated with SCFIs. The aim of this study was to evaluate the prevalence and causative agents of dermatomycoses over a period of 10 years in Kerman province, southeast of Iran. METHODS: A number of 1782 subjects, including 1096 females and 686 males, with cutaneous disorders in their skin, nail, and hair suspected to have SCFIs participated in this study...
July 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28749293/diagnosis-and-successful-treatment-of-a-potentially-zoonotic-dermatophytosis-caused-by-microsporum-gypseum-in-a-zoo-housed-north-american-porcupine-erethizon-dorsatum
#18
Christine E Hackworth, David Eshar, Melissa Nau, Mary Bagladi-Swanson, Gordon A Andrews, James W Carpenter
A female North American porcupine ( Erethizon dorsatum ) was evaluated for a unilateral pedal crusting and alopecic dermatopathy. Fungal culture and histopathology testing revealed Microsporum gypseum dermatophytosis. Treatment with topical miconazole was initiated and then discontinued after 9 days and changed to oral terbinafine. Twenty-eight days after initial examination, clinical signs were improving, and fungal cultures of the front foot, muzzle, and noninfected area along the dorsum were negative for M...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28712918/topical-nitric-oxide-releasing-nanoparticles-are-effective-in-a-murine-model-of-dermal-trichophyton-rubrum-dermatophytosis
#19
Breanne Mordorski, Caroline Barcelos Costa-Orlandi, Ludmila M Baltazar, Leandro J Carreño, Angelo Landriscina, Jamie Rosen, Mahantesh Navati, Maria Jose Soares Mendes-Giannini, Joel M Friedman, Joshua D Nosanchuk, Adam J Friedman
Systemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. However, systemic antifungals are associated with off-target effects and limited tissue penetration, and antimicrobial resistance is a growing concern. To address this, we investigated topical nitric oxide-releasing nanoparticles (NO-np), which have been used against superficial fungal infections and bacterial abscesses. In addition to enhanced penetration and permeation conferred by nanoparticles, nitric oxide, a broad-spectrum multi-mechanistic antimicrobial agent, offers decreased likelihood of resistance development...
October 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28708048/quantitative-and-structural-analyses-of-the-in-vitro-and-ex-vivo-biofilm-forming-ability-of-dermatophytes
#20
Raimunda Sâmia Nogueira Brilhante, Edmilson Emanuel Monteiro Correia, Glaucia Morgana de Melo Guedes, Vandbergue Santos Pereira, Jonathas Sales de Oliveira, Silviane Praciano Bandeira, Lucas Pereira de Alencar, Ana Raquel Colares de Andrade, Débora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Adriana de Queiroz Pinheiro, Lúcio Jackson Queiroz Chaves, Waldemiro de Aquino Pereira Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
PURPOSE: The aim of this study was to evaluate the in vitro and ex vivo biofilm-forming ability of dermatophytes on a nail fragment. METHODOLOGY: Initially, four isolates of Trichophyton rubrum, six of Trichophyton tonsurans, three of Trichophyton mentagrophytes, ten of Microsporum canis and three of Microsporum gypseum were tested for production biomass by crystal violet assay. Then, one strain per species presenting the best biofilm production was chosen for further studies by optical microscopy (Congo red staining), confocal laser scanning (LIVE/DEAD staining) and scanning electron (secondary electron) microscopy...
July 2017: Journal of Medical Microbiology
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