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Dermatophytosis

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https://www.readbyqxmd.com/read/28802670/chemoselective-fluorination-and-chemoinformatic-analysis-of-griseofulvin-natural-vs-fluorinated-fungal-metabolites
#1
Noemi D Paguigan, Mohammed H Al-Huniti, Huzefa A Raja, Austin Czarnecki, Joanna E Burdette, Mariana González-Medina, José L Medina-Franco, Stephen J Polyak, Cedric J Pearce, Mitchell P Croatt, Nicholas H Oberlies
Griseofulvin is a fungal metabolite and antifungal drug used for the treatment of dermatophytosis in both humans and animals. Recently, griseofulvin and its analogues have attracted renewed attention due to reports of their potential anticancer effects. In this study griseofulvin (1) and related analogues (2-6, with 4 being new to literature) were isolated from Xylaria cubensis. Six fluorinated analogues (7-12) were synthesized, each in a single step using the isolated natural products and Selectflour, so as to examine the effects of fluorine incorporation on the bioactivities of this structural class...
July 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28794551/efficacy-and-safety-of-terbinafine-500-mg-once-daily-in-patients-with-dermatophytosis
#2
P Ravindra Babu, A J S Pravin, Gaurav Deshmukh, Dhiraj Dhoot, Aniket Samant, Bhavesh Kotak
INTRODUCTION: Dermatophytosis are the most common fungal infections globally. Terbinafine is considered to have good potency against dermatophytes, but resistance to terbinafine is on the rise. OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of terbinafine 500 mg given once daily in treatment of patients with superficial dermatophytosis. MATERIALS AND METHODS: It was a retrospective questionnaire-based survey...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28757272/epidemiology-of-dermatomycoses-in-kerman-province-southeast-of-iran-a-10-years-retrospective-study-2004-2014
#3
Samira Salari, Seyyed Amin Ayatollahi Mousavi, Sanaz Hadizadeh, Alireza Izadi
OBJECTIVES: Superficial and cutaneous fungal infections (SCFIs) are an important public health problem and are common in tropical and subtropical countries. Pityriasis versicolor, dermatophytosis, erythrasma, onychomycosis, and otomycosis are the major diseases associated with SCFIs. The aim of this study was to evaluate the prevalence and causative agents of dermatomycoses over a period of 10 years in Kerman province, southeast of Iran. METHODS: A number of 1782 subjects, including 1096 females and 686 males, with cutaneous disorders in their skin, nail, and hair suspected to have SCFIs participated in this study...
July 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28749293/diagnosis-and-successful-treatment-of-a-potentially-zoonotic-dermatophytosis-caused-by-microsporum-gypseum-in-a-zoo-housed-north-american-porcupine-erethizon-dorsatum
#4
Christine E Hackworth, David Eshar, Melissa Nau, Mary Bagladi-Swanson, Gordon A Andrews, James W Carpenter
A female North American porcupine ( Erethizon dorsatum ) was evaluated for a unilateral pedal crusting and alopecic dermatopathy. Fungal culture and histopathology testing revealed Microsporum gypseum dermatophytosis. Treatment with topical miconazole was initiated and then discontinued after 9 days and changed to oral terbinafine. Twenty-eight days after initial examination, clinical signs were improving, and fungal cultures of the front foot, muzzle, and noninfected area along the dorsum were negative for M...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28712918/topical-nitric-oxide-releasing-nanoparticles-are-effective-in-a-murine-model-of-dermal-trichophyton-rubrum-dermatophytosis
#5
Breanne Mordorski, Caroline Barcelos Costa-Orlandi, Ludmila M Baltazar, Leandro J Carreño, Angelo Landriscina, Jamie Rosen, Mahantesh Navati, Maria Jose Soares Mendes-Giannini, Joel M Friedman, Joshua D Nosanchuk, Adam J Friedman
Systemic therapies are preferred for treating dermal dermatophytosis due to inadequate penetration of topical agents. However, systemic antifungals are associated with off-target effects and limited tissue penetration, and antimicrobial resistance is a growing concern. To address this, we investigated topical nitric oxide-releasing nanoparticles (NO-np), which have been used against superficial fungal infections and bacterial abscesses. In addition to enhanced penetration and permeation conferred by nanoparticles, nitric oxide, a broad-spectrum multi-mechanistic antimicrobial agent, offers decreased likelihood of resistance development...
July 13, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28708048/quantitative-and-structural-analyses-of-the-in-vitro-and-ex-vivo-biofilm-forming-ability-of-dermatophytes
#6
Raimunda Sâmia Nogueira Brilhante, Edmilson Emanuel Monteiro Correia, Glaucia Morgana de Melo Guedes, Vandbergue Santos Pereira, Jonathas Sales de Oliveira, Silviane Praciano Bandeira, Lucas Pereira de Alencar, Ana Raquel Colares de Andrade, Débora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Adriana de Queiroz Pinheiro, Lúcio Jackson Queiroz Chaves, Waldemiro de Aquino Pereira Neto, José Júlio Costa Sidrim, Marcos Fábio Gadelha Rocha
PURPOSE: The aim of this study was to evaluate the in vitro and ex vivo biofilm-forming ability of dermatophytes on a nail fragment. METHODOLOGY: Initially, four isolates of Trichophyton rubrum, six of Trichophyton tonsurans, three of Trichophyton mentagrophytes, ten of Microsporum canis and three of Microsporum gypseum were tested for production biomass by crystal violet assay. Then, one strain per species presenting the best biofilm production was chosen for further studies by optical microscopy (Congo red staining), confocal laser scanning (LIVE/DEAD staining) and scanning electron (secondary electron) microscopy...
July 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28699277/clinical-evaluation-of-%C3%AE-tubulin-real-time-pcr-for-rapid-diagnosis-of-dermatophytosis-a-comparison-with-mycological-methods
#7
Marjan Motamedi, Hossein Mirhendi, Kamiar Zomorodian, Hossein Khodadadi, Mahboobeh Kharazi, Zeinab Ghasemi, Mohammad Reza Shidfar, Koichi Makimura
Following our previous report on evaluation of the beta tubulin real-time PCR for detection of dermatophytosis, this study aimed to compare the real-time PCR assay with conventional methods for the clinical assessment of its diagnostic performance. Samples from a total of 853 patients with suspected dermatophyte lesions were subjected to direct examination (all samples), culture (499 samples) and real-time PCR (all samples). Fungal DNA was extracted directly from clinical samples using a conical steel bullet, followed by purification with a commercial kit and subjected to the Taq-Man probe-based real-time PCR...
July 12, 2017: Mycoses
https://www.readbyqxmd.com/read/28681027/epidemiological-survey-of-dermatophytosis-in-damascus-syria-from-2008-to-2016
#8
M T Ismail, A Al-Kafri
BACKGROUND AND PURPOSE: It is important to follow annually the probable changes in distribution pattern of dermatophytosis and its etiological agents in different communities. In this study, we determined the prevalence of dermatophytosis and its causative agents in Damascus, Syria, between 2008 and 2016. MATERIALS AND METHODS: A total of 4080 outpatients who visited the dermatological clinics in Damascus, were evaluated. The specimens were collected from clinically suspected tinea...
September 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28622851/prevalence-and-zoonotic-risks-of-trichophyton-mentagrophytes-and-cheyletiella-spp-in-guinea-pigs-and-rabbits-in-dutch-pet-shops
#9
P A M Overgaauw, K H A van Avermaete, C A R M Mertens, M Meijer, N J Schoemaker
Young rabbits and guinea pigs are often purchased as pets for children and may be infected with zoonotic skin infections. To assess the risk of acquiring such an infection from rabbits or guinea pigs, this study investigated the prevalence of the fungus Trichophyton mentagrophytes and the fur mite Cheyletiella parasitovorax in asymptomatic rabbits and guinea pigs in Dutch pet shops. In 91 pet shops a total of 213 rabbits and 179 guinea pigs were sampled using the Mackenzie technique and cultured. Clean cultures were examined microscopically and a PCR was performed on at least one sample from each pet shop...
June 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28616693/-tinea-barbae-profunda-due-to-trichophyton-mentagrophytes-after-journey-to-thailand-case-report-and-review
#10
REVIEW
G Wendrock-Shiga, D Mechtel, S Uhrlaß, D Koch, C Krüger, P Nenoff
Tinea barbae represents a very rare dermatophytosis. We report on a tinea barbae profunda following a journey to Southeast Asia. After travel to Thailand, a businessman was affected by a foudroyant proceeding abscessing infection of the upper lip and beard area. The initial therapy with oral acyclovir and oral ciprofloxacin, which later was changed to ampicillin plus sulbactam, intravenously, was unsuccessful. In a biopsy sample, histologically, with Grocott-Gomori's methenamine silver stain, fungal mycelium was apparent in the tissue...
August 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28588164/diagnosis-of-dermatophytosis-by-conventional-methods-and-comparatative-analysis-of-sabouraud-dextrose-agar-and-dermatophyte-test-medium-for-isolation-of-dermatophytes
#11
S Monwar, M A Hossain, F Boby, H Begum, N Begum
Dermatophytosis is a fungal disease which ranked as one of the most common cutaneous condition in all over the world. The aim of this cross sectional observational study is to identify the etiological agent of dermatophytosis and comparison of Sabouraud dextrose agar (SDA) and Dermatophyte test medium (DTM) for the primary isolation of dermatophytes among the clinically suspected cases of dermatophytosis from the outpatient Department of Dermatology and Venereology, Mymensingh Medical College Hospital from July 2013 to December 2015...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28584364/the-great-indian-epidemic-of-superficial-dermatophytosis-an-appraisal
#12
EDITORIAL
Shyam Verma, R Madhu
No abstract text is available yet for this article.
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#13
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28516493/diagnosis-and-treatment-of-dermatophytosis-in-dogs-and-cats-clinical-consensus-guidelines-of-the-world-association-for-veterinary-dermatology
#14
REVIEW
Karen A Moriello, Kimberly Coyner, Susan Paterson, Bernard Mignon
BACKGROUND: Dermatophytosis is a superficial fungal skin disease of cats and dogs. The most common pathogens of small animals belong to the genera Microsporum and Trichophyton. It is an important skin disease because it is contagious, infectious and can be transmitted to people. OBJECTIVES: The objective of this document is to review the existing literature and provide consensus recommendations for veterinary clinicians and lay people on the diagnosis and treatment of dermatophytosis in cats and dogs...
June 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28513812/common-dermatophytes-and-in-vitro-anti-fungal-susceptibility-testing-in-patients-attending-the-dermatological-clinic-at-the-hospital-for-tropical-medicine-bangkok
#15
Watcharamat Muangkaew, Thanwa Wongsuk, Natthanej Luplertlop
Dermatophytes comprising the genera Trichophyton, Microsporum, and Epidermophyton are important causes of superficial mycoses. The number of infected patients and the distribution of species of these organisms in our hospital were unknown. We therefore aimed to investigate the clinical pattern of dermatophyte infections and to identify the species of these dermatophytes at the Dermatological Clinic of the Hospital for Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok in a 1-year period...
May 17, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28501468/-tinea-capitis-main-mycosis-child-epidemiological-study-on-10years
#16
A Kallel, A Hdider, N Fakhfakh, S Belhadj, N Belhadj-Salah, N Bada, A Chouchen, S Ennigrou, K Kallel
Despite the changes in their epidemiology, and the improving level of hygiene of the population, tinea capitis is still considered a public health problem in our country, and is the most common type of dermatophytosis in our country. The aim of our study was to evaluate the epidemiological, clinical and mycological features of tinea capitis in children encountered in the Tunis region. A retrospective study concerned 1600 children aged 6 months to 15 years suspected to have tinea capitis was conducted in Parasitology-Mycology laboratory, Rabta hospital, over a 10-years period (2005-2014)...
May 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28494177/influence-of-low-level-laser-on-pain-and-inflammation-in-type-2-diabetes-mellitus-with-diabetic-dermopathy-a-case-report
#17
Animesh Hazari, Shivashankara K N, Karthik K Rao, Arun G Maiya
Numerous skin lesions have been commonly observed in individuals with diabetes mellitus. The common skin manifestations of diabetes mellitus are erythrasma, xanthomatosis, xanthelasma, phycomycetes and cutaneous infections like furuncolosis, candidiasis, carbuncle, dermatophytosis, etc. Diabetic dermopathy is the most common skin lesion found in patients with diabetes. It is typically seen in men aged above 50 years. In low-level laser therapy (LLLT), the entire lower limb was illuminated with the frequency of 20 Hz and wavelength of 830 nm for 9 min, and the treatment was divided into four parts...
May 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28462859/exfoliative-erythroderma-and-palmoplantar-hyperkeratosis-associated-with-majocchi-s-granuloma-by-trichophyton-tonsurans-in-a-patient-with-aids
#18
Marcelo R Lyra, Bruna Muniz Álvarez, Andrea L Lanziano, Maria Auxiliadora A Imbeth, Adriana M Sá, Tullia Cuzzi, Jeferson C Oliveira, Armando O Schubach
BACKGROUND: Dermatophytoses are skin superficial mycoses in which clinical manifestations are directly related to the virulence of the infecting microorganism or the host immunity. CASE REPORT: We describe a severe case of dermatophytosis associated with exfoliative erythroderma, substantial palmoplantar keratoderma, onychodystrophy affecting all nails, diffuse non-scarring alopecia and tissue fungal invasion by Trichophyton tonsurans, which led us to the diagnosis of AIDS...
July 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28425361/assessment-of-real-time-pcr-cycle-threshold-values-in-microsporum-canis-culture-positive-and-culture-negative-cats-in-an-animal-shelter-a-field-study
#19
Linda S Jacobson, Lauren McIntyre, Jenny Mykusz
Objectives Real-time PCR provides quantitative information, recorded as the cycle threshold (Ct) value, about the number of organisms detected in a diagnostic sample. The Ct value correlates with the number of copies of the target organism in an inversely proportional and exponential relationship. The aim of the study was to determine whether Ct values could be used to distinguish between culture-positive and culture-negative samples. Methods This was a retrospective analysis of Ct values from dermatophyte PCR results in cats with suspicious skin lesions or suspected exposure to dermatophytosis...
April 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28419352/dermatophytes-and-dermatophytosis-in-the-eastern-and-southern-parts-of-africa
#20
E I Nweze, I E Eke
Dermatophytosis is currently a disease of global importance and a public health burden. It is caused by dermatophytes, which attack and grow on dead animal keratin. Dermatophytes belong to three genera, namely, Epidermophyton, Microsporum, and Trichophyton. The predominant clinical forms and causative agents vary from one region of the world to another. Poor socioeconomic status, high population densities, and poor sanitary conditions are some of the factors responsible for the high prevalence of dermatophytosis in many developing countries, which include countries in southern and eastern Africa, the focus of this review...
April 17, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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