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Dermatophytosis

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https://www.readbyqxmd.com/read/29778198/molecular-characterization-of-dermatophytes-isolated-from-cattle-in-plateau-state-nigeria
#1
James S Dalis, Haruna M Kazeem, Jacob K P Kwaga, Clara N Kwanashie, Bitrus Yakubu, Olajide A Owolodun, Anvou R Jambol
Dermatophytes from cattle were successfully characterized to species and strain levels for the first time in Nigeria. This study was undertaken to isolate and characterize dermatophytes from cattle in Plateau State, Nigeria. Two molecular techniques were utilized. The first was the use of polymerase chain reaction (PCR) to amplify the internal transcribed spacer regions of the ribosomal DNA using ITS-1 and ITS-4 as primers. This was followed by restriction fragment length polymorphism analysis of the amplified ITS regions using the enzyme MvaI to identify dermatophyte species...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29767491/dermatophytosis-in-a-psoriatic-patient-treated-with-secukinumab-an-underrated-adverse-effect
#2
Camilla Loi, Annalisa Patrizi, Andrea Sechi, Federico Tartari, Michela Magnano, Federico Bardazzi
No abstract text is available yet for this article.
August 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29761873/infection-of-trichophyton-verrucosum-in-cattle-breeders-poland-a-40-year-retrospective-study-on-the-genomic-variability-of-strains
#3
Sebastian Gnat, Dominik Łagowski, Aneta Nowakiewicz, Aleksandra Trościańczyk, Przemysław Zięba
BACKGROUND: Trichophyton verrucosum is a zoophilic fungus that is the most frequent etiologic agent of dermatophytosis in cattle. During the last few years, the number of cases of T. verrucosum from humans has been increasing constantly, which is correlated with the presence of cattle rearing farms. OBJECTIVES: We identified and analysed T. verrucosum strains isolated from humans and cattle. METHODS: Identification was carried out traditionally by correlating both the clinical manifestations with a micro- and macroscopic examination...
May 15, 2018: Mycoses
https://www.readbyqxmd.com/read/29707673/phytochemical-analysis-and-docking-study-of-compounds-present-in-a-polyherbal-preparation-used-in-the-treatment-of-dermatophytosis
#4
Nagesh Simhadri Vsdna, Muthuchamy Muniappan, Iyanar Kannan, Subramanyam Viswanathan
Background and Purpose: Soleshine is a polyherbal preparation established in the market for the treatment of cracks and tinea pedis, which is applied externally. This preparation is composed of the extracts of indigenous plants, namely Azadirachta indica, Lawsonia alba, and Shorea robusta , mixed with castor oil and sesame oil. In the present study, an attempt was made to identify the constituents of soleshine and identify some potential drug-like molecules that can inhibit important drug targets of the dermatophytes using molecular docking method...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29706004/indian-irrational-skin-creams-and-steroid-modified-dermatophytosis-an-unholy-nexus-and-alarming-situation
#5
Shyam Bhanu Verma, Christos Zouboulis
A veritable epidemic of alarming superficial dermatophytosis (tinea), predominantly tinea corporis, tinea cruris and tinea facei has swept through India in approximately past five years or so. Dermatologists and academic departments from across the nation observe that between 20-50% patients attending the outpatient department seek treatment of tinea. A large number of these patients have recalcitrant disease. While the alarming outbreak of tinea has prompted a relatively recent surge of academic studies there is a stark paucity of reliable, nationwide epidemiological data and lack of evidence in all aspects of the disease...
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29664175/evaluation-of-the-value-of-staining-hair-samples-with-a-modified-wright-giemsa-stain-and-or-showing-illustrated-guidelines-for-the-microscopic-diagnosis-of-dermatophytosis-in-cats
#6
Rareş Căpitan, Carlo Schievano, Chiara Noli
BACKGROUND: Direct examination of the hair is a simple diagnostic test for the diagnosis of dermatophytosis; training is needed to use this test. HYPOTHESIS/OBJECTIVES: To evaluate whether use of modified Wright-Giemsa blue stain and/or photographic images of infected and uninfected hairs improved the user's ability to identify infected or uninfected hairs. ANIMALS: Ten cats with, and 10 cats without, dermatophytosis due to Microsporum canis (n = 20)...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29657238/the-first-report-of-terbinafine-resistance-microsporum-canis-from-a-cat
#7
Yun-Hsia Hsiao, Charles Chen, Hock Siew Han, Rui Kano
A 2-year-old, exotic shorthair cat presented with baldness and mild scaling on trunk that was confirmed as Microsporum canis (M. canis) infection by the following methods. Wood's lamp and trichogram were used to demonstrate fungal elements suggestive of dermatophytosis consistent with M. canis. Dermatophyte test medium (DTM) and polymerase chain reaction (PCR) were used for identification. E-test and broth microdilution test were then utilized to estimate antifungal minimal inhibitory concentrations (MICs) towards ITZ and TRF respectively...
April 16, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29657191/erratum-intracutaneous-pharmacokinetics-of-oral-antifungals-and-their-relevance-in-recalcitrant-cutaneous-dermatophytosis-time-to-revisit-basics
#8
(no author information available yet)
[This corrects the article DOI: 10.4103/ijdvl.IJDVL_1012_16].
May 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29649923/diffuse-dermatophytosis-occurring-on-dimethyl-fumarate-therapy
#9
Jeffrey I Greenstein
BACKGROUND: Opportunistic infections have occurred during dimethyl fumarate (DMF) therapy. OBJECTIVE: Diffuse skin dermatophytosis which occurred during DMF therapy in the setting of lymphopenia is described. METHODS AND RESULTS: The clinical course, the lymphocyte subset profile, and dermatologic evaluations were reviewed. In both instances, there was no other cause of lymphopenia or immune suppression, and it is likely that the tinea infections are associated with DMF therapy...
April 1, 2018: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29644192/is-antifungal-resistance-a-cause-for-treatment-failure-in-dermatophytosis-a-study-focused-on-tinea-corporis-and-cruris-from-a-tertiary-centre
#10
Kabir Sardana, Ravinder Kaur, Pooja Arora, Ritu Goyal, Sneha Ghunawat
Background: Dermatophytoses are one of the most common skin diseases that have been largely simple to treat. However, in recent years, these infections have become recalcitrant to treatment which can possibly be due to antifungal resistance. Aim: To analyze the resistance pattern of patients with recalcitrant dermatophytoses. Materials and Methods: A cross-sectional evaluation was undertaken of 40 consecutive patients with recalcitrant tinea corporis/cruris/both who had taken systemic antifungal treatment and did not respond completely to therapy or had recurrent lesion within 1 month of stopping the therapy...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29606407/epidemiology-of-dermatophytoses-in-31-municipalities-of-the-province-of-buenos-aires-argentina-a-6-year-study
#11
Mariana Mazza, Nicolás Refojo, Graciela Davel, Nelson Lima, Nicolina Dias, Cosme Marcelo Furtado Passos da Silva, Cristina Elena Canteros
BACKGROUND: No reliable data are available in the province of Buenos Aires regarding the frequency of dermatophytoses and other fungal diseases. The distribution of the clinical forms and the species involved are also unknown. AIMS: To present the data collected by the laboratories participating in the Mycology Network of the province of Buenos Aires (MNPBA) from a retrospective epidemiological survey on dermatophytoses. METHODS: A descriptive and exploratory analysis was performed on the cases of dermatophytoses gathered between 2002 and 2007 by the Mycology Network of the province of Buenos Aires...
March 29, 2018: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29601109/fungal-diseases-in-children-and-adolescents-in-a-referral-centre-in-bogota-colombia
#12
Alvarado Zulma, Pereira Claudia
A cross-sectional descriptive study was conducted at a dermatology referral centre in Bogotá to estimate the frequencies and aetiologies of mycoses in the population under 18 years of age attending the medical mycology laboratory over a 13-year period (2000-2012). A total of 1337 samples from 1221 patients were evaluated, involving direct examination and culture for 1279 samples, direct examination alone for 50 and culture alone for 8. During the study period, dermatophytosis was diagnosed via culture in 537 cases (40...
March 30, 2018: Mycoses
https://www.readbyqxmd.com/read/29577447/high-terbinafine-resistance-in-trichophyton-interdigitale-isolates-in-delhi-india-harbouring-mutations-in-the-squalene-epoxidase-sqle-gene
#13
Ashutosh Singh, Aradhana Masih, Ananta Khurana, Pradeep Kumar Singh, Meenakshi Gupta, Ferry Hagen, Jacques F Meis, Anuradha Chowdhary
In the last few years infections caused by dermatophytes along with a concomitant increase in the number of difficult to treat cases has increasingly been recognized indicating that dermatophytosis remains a challenging public health problem. The majority of infections are caused by Trichophyton rubrum and T. mentagrophytes complex. Terbinafine, an allylamine antifungal used orally and topically is considered to be a first-line drug in the therapy of dermatophyte infections. Terbinafine resistance has been predominately attributed to point mutations in the squalene epoxidase (SQLE) target gene a key enzyme in the ergosterol biosynthetic pathway leading to single amino acid substitutions...
March 25, 2018: Mycoses
https://www.readbyqxmd.com/read/29573271/a-study-of-skin-disease-spectrum-occurring-in-angola-phototype-v-vi-population-in-luanda
#14
David A De Luca, Ziv Maianski, Michael Averbukh
BACKGROUND: Prevalence of skin diseases in Luanda (Angola) is unknown, and publications are barely found in the literature. We aim to describe, for the first time, the frequency of skin disease spectrum in phototype V-VI Angolan population in Luanda City. METHODS: We included Fitzpatrick phototype V-VI Angolan patients who consulted the Dermatology Unit in Luanda Medical Center during a 1-year period. Medical information was recovered from the electronic database, and diagnoses were based on ICD-10...
March 24, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29571944/interleukin-17-il-17-mediated-immunity-controls-skin-infection-and-t-helper-1-response-during-experimental-microsporum-canis-dermatophytosis
#15
V L Burstein, L Guasconi, I Beccacece, M G Theumer, C Mena, I Prinz, L Cervi, M Herrero, D T Masih, L S Chiapello
Despite worldwide prevalence of superficial mycoses, the immune response in dermatophytosis has scarcely been investigated. In this study, we developed a model of superficial skin infection in C57BL/6 mice with Microsporum canis, a highly prevalent human pathogen. This model mimics mild inflammatory human dermatophytosis, characterized by neutrophil recruitment and fungal invasion limited to the epidermis, and exhibits the establishment of a specific T helper 17 (Th17) immune response during infection. By using IL-17RA or IL-17A/F deficient mice we showed that, in the absence of a functional IL-17 pathway, M...
March 20, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#16
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29560532/landscape-of-long-non-coding-rnas-in-trichophyton-mentagrophytes-induced-rabbit-dermatophytosis-lesional-skin-and-normal-skin
#17
Wudian Xiao, Yongsong Hu, Yan Tong, Mingcheng Cai, Hongbing He, Buwei Liu, Yu Shi, Jie Wang, Yinghe Qin, Songjia Lai
Emerging evidences suggest that long non-coding RNAs (lncRNAs) play important role in disease development. However, the role of rabbit lncRNAs in the pathogenesis of dermatophytosis remains elusive. The present study aimed to study and characterize lncRNA transcriptome in 8 T. mentagrophytes-induced female rabbit dermatophytosis lesional (TM) and 4 normal saline-infected (NS) skin biopsies using RNAseq. We identified 5883 lncRNAs in 12 strand-specific RNA-seq libraries and found 64 differentially expressed lncRNAs (q < 0...
March 20, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29557619/-tinea-capitis-by-microsporum-gypseum-an-infrequent-species
#18
Lidia García-Agudo, Jorge J Espinosa-Ruiz
Tinea capitis is considered the most frequent dermatophyte infection in children. The etiological agents vary from time to time and by geographical area, although they normally are zoophilic dermatophytes and in the last years also anthropophilic species. We report a clinical case of inflammatory tinea capitis in a 6-year-old child caused by Microsporum gypseum, a geophilic fungus pathogenic to humans and animals. The sources of human infection are soil, cats, dogs and small mammals. This species is less frequent as a cause of dermatophytosis in humans, described mainly in tinea corporis and rarely in tinea capitis...
April 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29556453/subcutaneous-abscesses-caused-by-trichophyton-rubrum-in-the-unilateral-groin-of-an-immunocompromised-patient-a-case-report
#19
Utako Okata-Karigane, Yasuki Hata, Emiko Watanabe-Okada, Shunichi Miyakawa, Michi Ota, Yutaka Uzawa, Shigekazu Iguchi, Atsushi Yoshida, Ken Kikuchi
A 60-year-old Japanese man presented with multiple subcutaneous nodules in his left groin. Histologically, the nodules consisted of suppurative granulomas and abscesses not involving the hair follicles. Trichophyton rubrum TWCC57922 was detected by fungal culture and polymerase chain reaction (PCR) sequencing of the rDNA genes. We diagnosed these nodules as deeper dermal dermatophytosis, a rare form of invasive dermatophytosis. He was treated with terbinafine. We compared these findings with previous reports of deep dermal dermatophytosis...
September 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29554937/awareness-of-zoonotic-diseases-and-parasite-control-practices-a-survey-of-dog-and-cat-owners-in-qatar
#20
Ana Margarida Alho, Clara Lima, Vito Colella, Luís Madeira de Carvalho, Domenico Otranto, Luís Cardoso
BACKGROUND: Qatar is one of the wealthiest and fastest growing economies in the world, experiencing a rapid increase in human and pet populations. Given the paucity of data on prophylactic measures against endo- and ectoparasites of pets in Qatar, as well as on the owners' awareness of zoonotic diseases, a questionnaire was conducted. METHODS: From July to November 2017, 150 multiple-choice questionnaires were administered to dog and/or cat owners who attended two veterinary clinics in Doha...
March 20, 2018: Parasites & Vectors
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