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british journal of surgery

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https://www.readbyqxmd.com/read/28095396/tenascin-c-and-fibronectin-expression-divide-early-stage-tongue-cancer-into-low-and-high-risk-groups
#1
Elias Sundquist, Joonas H Kauppila, Johanna Veijola, Rayan Mroueh, Petri Lehenkari, Saara Laitinen, Juha Risteli, Ylermi Soini, Veli-Matti Kosma, Iris Sawazaki-Calone, Carolina Carneiro Soares Macedo, Risto Bloigu, Ricardo D Coletta, Tuula Salo
BACKGROUND: Oral tongue squamous cell carcinoma (OTSCC) metastasises early, especially to regional lymph nodes. There is an ongoing debate on which early stage (T1-T2N0) patients should be treated with elective neck dissection. We need prognosticators for early stage tongue cancer. METHODS: Mice immunisation with human mesenchymal stromal cells resulted in production of antibodies against tenascin-C (TNC) and fibronectin (FN), which were used to stain 178 (98 early stage), oral tongue squamous cell carcinoma samples...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28081544/nomogram-to-predict-pathologic-complete-response-in-her2-positive-breast-cancer-treated-with-neoadjuvant-systemic-therapy
#2
Takeo Fujii, Takahiro Kogawa, Jimin Wu, Aysegul A Sahin, Dian D Liu, Mariana Chavez-MacGregor, Sharon H Giordano, Akshara Raghavendra, Rushmy K Murthy, Debu Tripathy, Yu Shen, Jose-Miguel Yamal, Naoto T Ueno
BACKGROUND: Pathologic complete response (pCR) is associated with improved survival outcomes in patients with HER2-positive primary breast cancer. We developed a nomogram to predict the probability of pCR rates by using oestrogen receptor (ER) expression, progesterone receptor (PR) expression and HER2/CEP17 ratio as continuous variables. METHODS: We retrospectively reviewed patients with stages I-III HER2-positive invasive breast cancer who had definitive surgery in 1999-2015 and received neoadjuvant systemic therapy (NST)...
January 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28056465/the-impact-of-age-on-complications-survival-and-cause-of-death-following-colon-cancer-surgery
#3
Christopher T Aquina, Supriya G Mohile, Mohamedtaki A Tejani, Adan Z Becerra, Zhaomin Xu, Bradley J Hensley, Reza Arsalani-Zadeh, Francis P Boscoe, Maria J Schymura, Katia Noyes, John Rt Monson, Fergal J Fleming
BACKGROUND: Given scarce data regarding the relationship among age, complications, and survival beyond the 30-day postoperative period for oncology patients in the United States, this study identified age-related differences in complications and the rate and cause of 1-year mortality following colon cancer surgery. METHODS: The NY State Cancer Registry and Statewide Planning and Research Cooperative System identified stage I-III colon cancer resections (2004-2011)...
January 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27997526/organ-preservation-with-local-excision-or-active-surveillance-following-chemoradiotherapy-for-rectal-cancer
#4
B Creavin, E Ryan, S T Martin, A Hanly, P R O'Connell, K Sheahan, D C Winter
BACKGROUND: Organ preservation has been proposed as an alternative to radical surgery for rectal cancer to reduce morbidity and mortality, and to improve functional outcome. METHODS: Locally advanced non-metastatic rectal cancers were identified from a prospective database. Patients staged ⩾T3 or any stage N+ were referred for neoadjuvant chemoradiotherapy (CRT) (50-54 Gy and 5-fluorouracil), and were reassessed 6-8 weeks post treatment. An active surveillance programme ('watch and wait') was offered to patients who were found to have a complete endoluminal response...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27959889/childhood-neuroendocrine-tumours-a-descriptive-study-revealing-clues-for-genetic-predisposition
#5
I J Diets, I D Nagtegaal, J Loeffen, I de Blaauw, E Waanders, N Hoogerbrugge, M C J Jongmans
BACKGROUND: Neuroendocrine tumours (NETs) are rare in children and limited data are available. We aimed to specify tumour and patient characteristics and to investigate the role of genetic predisposition in the aetiology of paediatric NETs. METHODS: Using the Dutch Pathology Registry PALGA, we collected patient- and tumour data of paediatric NETs in the Netherlands between 1991 and 2013 (N=483). RESULTS: The incidence of paediatric NETs in the Netherlands is 5...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27931046/perivascular-pdgfr-%C3%AE-is-an-independent-marker-for-prognosis-in-renal-cell-carcinoma
#6
Magnus Frödin, Artur Mezheyeuski, Sara Corvigno, Ulrika Harmenberg, Per Sandström, Lars Egevad, Martin Johansson, Arne Östman
BACKGROUND: Renal cell carcinoma (RCC) is a highly vascularised tumour, where anti-angiogenic treatment with multi-tyrosine-kinase-inhibitor, is used for first-line treatment of metastatic disease. Variations in vascular characteristics are likely to contribute to variations in intrinsic aggressiveness of the disease. Emerging studies are identifying perivascular status, including perivascular PDGFR-β, as a determinant of prognosis in other tumour types. METHODS: This work explored the impact on prognosis of vascular characteristics in RCC through analyses of a population-based collection of tumours from surgery-alone-treated patients...
January 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27907930/microrna-profiling-in-clear-cell-renal-cell-carcinoma-tissues-potentially-links-tumorigenesis-and-recurrence-with-obesity
#7
X Shu, M A Hildebrandt, J Gu, N M Tannir, S F Matin, J A Karam, C G Wood, X Wu
BACKGROUND: Twenty to 40% localised RCC patients may experience recurrence after curative surgery. Limited miRNA predictors have been identified for ccRCC recurrence. METHODS: Through a multi-phase study design, we analysed miRNAs in tissues obtained from 203 ccRCC patients. Paired t-test was used for tumour-normal comparisons and Cox regression model was performed to compute hazard ratios (HRs) and corresponding 95% CIs. RESULTS: A 17-miRNA signature was identified that can concordantly classify >95% of tumour/adjacent normal samples...
January 3, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27864623/simplified-hcc-art-score-for-highly-sensitive-detection-of-small-sized-and-early-stage-hepatocellular-carcinoma-in-the-widely-used-okuda-clip-and-bclc-staging-systems
#8
Abdelfattah M Attallah, Mohamed M Omran, Ahmed A Attallah, Mohamed A Abdelrazek, Khaled Farid, Ibrahim El-Dosoky
BACKGROUND: Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. METHODS: 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC...
November 18, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27855106/the-ibra-2-immediate-breast-reconstruction-and-adjuvant-therapy-audit-study-protocol-for-a-prospective-national-multicentre-cohort-study-to-evaluate-the-impact-of-immediate-breast-reconstruction-on-the-delivery-of-adjuvant-therapy
#9
Rajiv Dave, Rachel O'Connell, Tim Rattay, Zoe Tolkien, Nicola Barnes, Joanna Skillman, Paula Williamson, Elizabeth Conroy, Matthew Gardiner, Adrian Harnett, Ciara O'Brien, Jane Blazeby, Shelley Potter, Chris Holcombe
INTRODUCTION: Immediate breast reconstruction (IBR) is routinely offered to improve quality of life for women with breast cancer requiring a mastectomy, but there are concerns that more complex surgery may delay the delivery of adjuvant oncological treatments and compromise long-term oncological outcomes. High-quality evidence, however, is lacking. iBRA-2 is a national prospective multicentre cohort study that aims to investigate the effect of IBR on the delivery of adjuvant therapy. METHODS AND ANALYSIS: Breast and plastic surgery centres in the UK performing mastectomy with or without (±) IBR will be invited to participate in the study through the trainee research collaborative network...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27811857/phase-ii-study-of-chemoselection-with-docetaxel-plus-cisplatin-and-5-fluorouracil-induction-chemotherapy-and-subsequent-conversion-surgery-for-locally-advanced-unresectable-oesophageal-cancer
#10
Tomoya Yokota, Ken Kato, Yasuo Hamamoto, Yasuhiro Tsubosa, Hirofumi Ogawa, Yoshinori Ito, Hiroki Hara, Takashi Ura, Takashi Kojima, Keisho Chin, Shuichi Hironaka, Takayuki Kii, Yasushi Kojima, Yasunori Akutsu, Hisayuki Matsushita, Kentaro Kawakami, Keita Mori, Yushi Nagai, Chika Asami, Yuko Kitagawa
BACKGROUND: The standard treatment for locally advanced unresectable squamous cell carcinoma (SCC) of the oesophagus is chemoradiation with cisplatin and 5-fluorouracil (CF-RT). This multicentre phase II trial assessed the safety and efficacy of chemoselection with docetaxel plus cisplatin and 5-fluorouracil (DCF) induction chemotherapy (ICT) and subsequent conversion surgery (CS) for initially unresectable locally advanced SCC of the oesophagus. METHODS: Patients with clinical T4 and/or unresectable supraclavicular lymph node metastasis were eligible...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27802451/microrna-193b-3p-as-a-predictive-biomarker-of-chronic-kidney-disease-in-patients-undergoing-radical-nephrectomy-for-renal-cell-carcinoma
#11
Francesco Trevisani, Michele Ghidini, Alessandro Larcher, Andrea Lampis, Hazel Lote, Paolo Manunta, Maria Teresa Sciarrone Alibrandi, Laura Zagato, Lorena Citterio, Giacomo Dell'Antonio, Cristina Carenzi, Giovambattista Capasso, Massimo Rugge, Paolo Rigotti, Roberto Bertini, Luciano Cascione, Alberto Briganti, Andrea Salonia, Fabio Benigni, Chiara Braconi, Matteo Fassan, Jens Claus Hahne, Francesco Montorsi, Nicola Valeri
BACKGROUND: A significant proportion of patients undergoing radical nephrectomy (RN) for clear-cell renal cell carcinoma (RCC) develop chronic kidney disease (CKD) within a few years following surgery. Chronic kidney disease has important health, social and economic impact and no predictive biomarkers are currently available. MicroRNAs (miRs) are small non-coding RNAs implicated in several pathological processes. METHODS: Primary objective of our study was to define miRs whose deregulation is predictive of CKD in patients treated with RN...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27780192/pathogenesis-and-progression-of-oesophageal-adenocarcinoma-varies-by-prior-diagnosis-of-barrett-s-oesophagus
#12
Michael B Cook, Jennifer Drahos, Shannon Wood, Lindsey Enewold, Ruth Parsons, Neal D Freedman, Philip R Taylor, Winnie Ricker, Christian C Abnet
BACKGROUND: The absolute risk of oesophageal adenocarcinoma (EA) among individuals with Barrett's oesophagus (BE) is low and a majority of EA cases are diagnosed among individuals with no prior BE diagnosis. To ensure that insights from EA case-control studies are transferable to clinical management of BE populations, we conducted a case-case study to compare the clinical presentation, medical history and survival of EA cases with and without a prior BE diagnosis in the Surveillance, Epidemiology and End Results Medicare database...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27701385/a-prognostic-profile-of-hypoxia-induced-genes-for-localised-high-grade-soft-tissue-sarcoma
#13
Ninna Aggerholm-Pedersen, Brita Singers Sørensen, Jens Overgaard, Kasper Toustrup, Steen Baerentzen, Ole Steen Nielsen, Katja Maretty-Kongstad, Marianne Nordsmark, Jan Alsner, Akmal Safwat
BACKGROUND: For decades, tumour hypoxia has been pursued as a cancer treatment target. However, prognostic and predictive biomarkers are essential for the use of this target in the clinic. This study investigates the prognostic value of a hypoxia-induced gene profile in localised soft tissue sarcoma (STS). METHODS: The hypoxia-induced gene quantification was performed by real-time quantitative PCR (RT-qPCR) of formalin-fixed, paraffin-embedded tissue samples. The gene expression cut-points were determined in a test cohort of 55 STS patients and used to allocate each patient into a more or a less hypoxic group...
October 25, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27537388/is-cancer-survival-associated-with-cancer-symptom-awareness-and-barriers-to-seeking-medical-help-in-england-an-ecological-study
#14
Maja Niksic, Bernard Rachet, Stephen W Duffy, Manuela Quaresma, Henrik Møller, Lindsay Jl Forbes
BACKGROUND: Campaigns aimed at raising cancer awareness and encouraging early presentation have been implemented in England. However, little is known about whether people with low cancer awareness and increased barriers to seeking medical help have worse cancer survival, and whether there is a geographical variation in cancer awareness and barriers in England. METHODS: From population-based surveys (n=35 308), using the Cancer Research UK Cancer Awareness Measure, we calculated the age- and sex-standardised symptom awareness and barriers scores for 52 primary care trusts (PCTs)...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27537385/long-term-results-of-fertility-sparing-treatment-compared-with-standard-radical-surgery-for-early-stage-epithelial-ovarian-cancer
#15
Robert Fruscio, Lorenzo Ceppi, Silvia Corso, Francesca Galli, Tiziana Dell'Anna, Federica Dell'Orto, Daniela Giuliani, Annalisa Garbi, Stefania Chiari, Costantino Mangioni, Rodolfo Milani, Irene Floriani, Nicoletta Colombo, Cristina Maria Bonazzi
BACKGROUND: The objective of this study is to evaluate the safety of fertility-sparing surgery (FSS) for early-stage epithelial ovarian cancer (EOC). METHODS: A retrospective analysis was performed to identify patients treated for early-stage EOC and to compare the clinical outcomes of patients treated with FSS and radical surgery (RS). RESULTS: A total of 1031 patients were treated at two Institutions, 242 with FSS (group A) and 789 with RS (group B)...
September 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27434036/patterns-of-progression-treatment-of-progressive-disease-and-post-progression-survival-in-the-new-epoc-study
#16
Siân A Pugh, Megan Bowers, Alexandre Ball, Stephen Falk, Meg Finch-Jones, Juan W Valle, Derek A O'Reilly, Ajith K Siriwardena, Joanne Hornbuckle, Myrddin Rees, Charlotte Rees, Tim Iveson, Tamas Hickish, Tom Maishman, Louise Stanton, Elizabeth Dixon, Andrea Corkhill, Mike Radford, O James Garden, David Cunningham, Tim S Maughan, John A Bridgewater, John N Primrose
BACKGROUND: The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome. METHODS: A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012...
August 9, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27389579/what-is-the-publication-rate-for-presentations-given-at-the-british-academic-conference-in-otolaryngology-baco
#17
A S Lau, G H Adan, M Krishnan, S C Leong
OBJECTIVES: The publication rate of some large academic meetings such as the American Academy of Otolaryngology-Head and Neck Surgery has been reported as 32%. We aimed to compare the rate of publication at the British Academic Conference in Otolaryngology (BACO) to allow surveillance of research activity in the United Kingdom (UK). DESIGN AND SETTING: The abstract records of both BACO 2009 and 2012 were examined. The MEDLINE database was searched using PubMed (http://www...
July 7, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27336603/specific-kras-amino-acid-substitutions-and-egfr-mutations-predict-site-specific-recurrence-and-metastasis-following-non-small-cell-lung-cancer-surgery
#18
Stéphane Renaud, Joseph Seitlinger, Pierre-Emmanuel Falcoz, Mickaël Schaeffer, Anne-Claire Voegeli, Michèle Legrain, Michèle Beau-Faller, Gilbert Massard
BACKGROUND: We aimed to evaluate whether EGFR mutations (mEGFR) and KRAS amino acid substitutions can predict first site of recurrence or metastasis after non-small-cell lung cancer (NSCLC) surgery. METHODS: Data were reviewed from 481 patients who underwent thoracic surgery for NSCLC between 2007 and 2012. RESULTS: Patients with KRAS G12C developed significantly more bone metastases compared with the remainder of the cohort (59% vs 16%, P<0...
July 26, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27336601/yttrium-90-radioembolization-for-unresectable-recurrent-intrahepatic-cholangiocarcinoma-a-survival-efficacy-and-safety-study
#19
Cristina Mosconi, Annagiulia Gramenzi, Salvatore Ascanio, Alberta Cappelli, Matteo Renzulli, Cinzia Pettinato, Giovanni Brandi, Fabio Monari, Alessandro Cucchetti, Franco Trevisani, Rita Golfieri
BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a rapidly progressing malignancy; only a minority of the tumours can be resected and the palliative regimens have shown limited success. The aim of this study was to assess overall survival (OS), tumour response and the safety of radioembolization with yttrium-90 ((90)Y-TARE) in patients with unresectable/recurrent ICC. METHODS: Survival was calculated from the date of the (90)Y-TARE procedure. Target and overall Response Evaluation Criteria in Solid Tumors (RECIST) and modified RECIST (mRECIST) and European Association for the Study of the Liver (EASL)-measuring delayed-phase contrast enhancement-treatment responses were assessed at 3 months...
July 26, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27280634/the-impact-of-hepatic-fibrosis-on-the-incidence-of-liver-metastasis-from-colorectal-cancer
#20
Takayuki Kondo, Koji Okabayashi, Hirotoshi Hasegawa, Masashi Tsuruta, Kohei Shigeta, Yuko Kitagawa
BACKGROUND: The aim of this study was to clarify the influence of hepatic fibrosis on metachronous liver-specific recurrence in colorectal cancer (CRC) patients who underwent colorectal surgery with curative intent. Non-alcoholic steatohepatitis (NASH) is closely associated with hepatic fibrosis (HF). The number of patients who suffer from NASH is increasing because of the consumption of high-calorie diets. It remains unclear how much of an impact NASH and HF have on the development of liver metastasis in CRC...
June 28, 2016: British Journal of Cancer
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