Rodrigo A Vargas, Sarita Soto-Aguilera, Mick Parra, Sebastian Herrera, Alvaro Santibañez, Camila Kossack, Claudia P Saavedra, Oscar Mora, Mauricio Pineda, Oscar Gonzalez, Alex Gonzalez, Kevin Maisey, Edgar Torres-Maravilla, Luis G Bermúdez-Humarán, Elkin Y Suárez-Villota, Mario Tello
Butyrate is a microbiota-produced metabolite, sensed by host short-chain fatty acid receptors FFAR2 (Gpr43), FFAR3 (Gpr41), HCAR2 (Gpr109A), and Histone deacetylase (HDAC) that promotes microbiota-host crosstalk. Butyrate influences energy uptake, developmental and immune response in mammals. This microbial metabolite is produced by around 79 anaerobic genera present in the mammalian gut, yet little is known about the role of butyrate in the host-microbiota interaction in salmonid fish. To further our knowledge of this interaction, we analyzed the intestinal microbiota and genome of Atlantic salmon ( Salmo salar ), searching for butyrate-producing genera and host butyrate receptors...
2023: Computational and Structural Biotechnology Journal