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https://www.readbyqxmd.com/read/29774180/survival-prediction-based-on-qualitative-mri-diffusion-signature-in-patients-with-recurrent-high-grade-glioma-treated-with-bevacizumab
#1
Pradeep Goyal, Mary Tenenbaum, Sonali Gupta, Puneet S Kochar, Alok A Bhatt, Manisha Mangla, Yogesh Kumar, Rajiv Mangla
Background: Bevacizumab was approved by the FDA for the treatment of recurrent or progressive glioblastoma (GBM). Imaging responses are typically assessed by gadolinium-enhanced MRI. We sought to determine the significance of qualitative diffusion signature (manifest as variable degree of dark signal) on ADC maps in recurrent gliomas after treatment with bevacizumab. Methods: We performed an institutional review board (IRB) approved retrospective study on patients who underwent MRI of the brain after 8 weeks of receiving bevacizumab for recurrent glioma...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29773299/diffusion-mri-in-acute-nervous-system-injury
#2
Matthew D Budde, Nathan P Skinner
Diffusion weighted magnetic resonance imaging (DWI) and related techniques such as diffusion tensor imaging (DTI) are uniquely sensitive to the microstructure of the brain and spinal cord. In the acute aftermath of nervous system injury, for example, DWI reveals changes caused by injury that remains invisible on other MRI contrasts such as T2 -weighted imaging. This ability has led to a demonstrated clinical utility in cerebral ischemia. However, despite strong promise in preclinical models and research settings, DWI has not been as readily adopted for other acute injuries such as traumatic spinal cord, brain, or peripheral nerve injury...
April 30, 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29771445/tirofiban-combined-with-rt-pa-intraarterial-thrombolysis-improves-the-recanalization-rate-of-acute-middle-cerebral-artery-occlusion-in-rabbits
#3
Y-J Yu, W Xiong
OBJECTIVE: To investigate the curative effect of tirofiban combined with recombinant tissue-plasminogen activator (rt-PA) selective intra-arterial thrombolysis on acute middle cerebral artery occlusion (MCAO). MATERIALS AND METHODS: A total of 60 adult male Japanese white rabbits weighing 2.5-3.0 kg were selected, and the acute cerebral infarction model was established via autologous thromboembolism of middle cerebral artery. Rabbits were randomly divided into 4 groups: tirofiban group (Ti group, 5 μg/kg, n=15), rt-PA group (rt-PA group, 2 mg/kg, n=15), tirofiban + rt-PA group (Ti + rt-PA group, 3 μg/kg Ti + 1 mg/kg rt-PA, n=15), and control group (Co group, n=15)...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29756324/prospective-frequency-correction-using-outer-volume-suppression-localized-navigator-for-mr-spectroscopy-and-spectroscopic-imaging
#4
Chu-Yu Lee, In-Young Choi, Phil Lee
PURPOSE: New frequency correction methods are required to achieve the accurate measurement of frequency drifts in MRS and MRSI. We present a prospective frequency correction method with outer volume suppression (OVS)-based localization and selective water excitation for effective frequency correction with better SNR improvement compared to other techniques. METHODS: An OVS-localized navigator was developed to prospectively correct frequency drifts during MRS and MRSI measurements...
May 13, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29729605/ethanolic-extract-ocimum-sanctum-enhances-cognitive-ability-from-young-adulthood-to-middle-aged-mediated-by-increasing-choline-acetyl-transferase-activity-in-rat-model
#5
Dwi Liliek Kusindarta, Hevi Wihadmadyatami, Arvendi R Jadi, Srikanth Karnati, Guenter Lochnit, Puspa Hening, Aris Haryanto, Made B Auriva, Medania Purwaningrum
Patients with dementia are increasing steadily, cognitive impairment by dementia not only exclusively suffers by old people but also young to middle aged individuals. However, the mechanism of cognitive impairment occurs in young people is not understood. Further, current medication to impairment did not provide satisfactory results. Therefore, we investigated the potential role of Ocimum sanctum ethanolic extract to enhance cognitive ability in the rat in vivo model. Young to middle aged rats were divided into 3 groups (3, 6, 9 months old) were treated with (0, 50 and 100 mg/kg b...
April 16, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29724766/diffusion-weighted-imaging-and-diffusion-tensor-imaging-for-differentiating-high-grade-glioma-from-solitary-brain-metastasis-a-systematic-review-and-meta-analysis
#6
C H Suh, H S Kim, S C Jung, S J Kim
BACKGROUND: Accurate diagnosis of high-grade glioma and solitary brain metastasis is clinically important because it affects the patient's outcome and alters patient management. PURPOSE: To evaluate the diagnostic performance of DWI and DTI for differentiating high-grade glioma from solitary brain metastasis. DATA SOURCES: A literature search of Ovid MEDLINE and EMBASE was conducted up to November 10, 2017. STUDY SELECTION: Studies evaluating the diagnostic performance of DWI and DTI for differentiating high-grade glioma from solitary brain metastasis were selected...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29724314/-value-of-magnetic-resonance-imaging-findings-in-differential-diagnosis-between-the-adult-reversible-splenial-lesion-syndrome-and-ischemic-infarction-of-the-splenium-of-the-corpus-callosum
#7
Xin Bo Xing, Wei Xi, Xin Kun Wang, Shu Hui Yang, Ming Ming Nie, Ming Yan Hu, Jing Mei Ren, Jia Fei Yang, Xin Lou
Objective To evaluate the magnetic resonance imaging (MRI) findings in differential diagnosis between the adult reversible splenial lesion syndrome (RESLES) and ischemic infarction of the splenium of the corpus callosum (SCC). Methods The MRI findings and clinical data of 7 RESLES patients and 13 patients with ischemic infarction of SCC who were clinically diagnosed and treated in our center from May 2015 to June 2017 were analyzed retrospectively. The main MRI findings included location,morphology,signal intensity,maximum cross-sectional area,diffusion weighted imaging (DWI),and apparent diffusion coefficient (ADC) value...
April 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29719596/the-value-of-whole-lesion-adc-histogram-profiling-to-differentiate-between-morphologically-indistinguishable-ring-enhancing-lesions-comparison-of-glioblastomas-and-brain-abscesses
#8
Diana Horvath-Rizea, Alexey Surov, Karl-Titus Hoffmann, Nikita Garnov, Cathrin Vörkel, Patricia Kohlhof-Meinecke, Oliver Ganslandt, Hansjörg Bäzner, Georg Alexander Gihr, Marcell Kalman, Elina Henkes, Hans Henkes, Stefan Schob
Background: Morphologically similar appearing ring enhancing lesions in the brain parenchyma can be caused by a number of distinct pathologies, however, they consistently represent life-threatening conditions. The two most frequently encountered diseases manifesting as such are glioblastoma multiforme (GBM) and brain abscess (BA), each requiring disparate therapeutical approaches. As a result of their morphological resemblance, essential treatment might be significantly delayed or even ommited, in case results of conventional imaging remain inconclusive...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29708785/interval-change-in-diffusion-and-perfusion-mri-parameters-for-the-assessment-of-pseudoprogression-in-cerebral-metastases-treated-with-stereotactic-radiation
#9
James R Knitter, William K Erly, Baldassarre D Stea, Gerald M Lemole, Isabelle M Germano, Amish H Doshi, Kambiz Nael
OBJECTIVE: Apparent increases in the size of cerebral metastases after stereotactic radiosurgery (SRS) can be caused by pseudoprogression or true disease progression, which poses a diagnostic challenge at conventional MRI. The purpose of this study was to assess whether interval change in DWI and perfusion MRI parameters can differentiate pseudoprogression from progressive disease after treatment with SRS. MATERIALS AND METHODS: Patients with apparent growth of cerebral metastases after SRS treatment who underwent pre- and post-SRS DWI, dynamic susceptibility contrast (DSC)-MRI, and perfusion dynamic contrast-enhanced (DCE)-MRI were retrospectively evaluated...
April 30, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29700045/diffusion-weighted-zonal-oblique-multislice-epi-enhances-the-detection-of-small-lesions-with-diffusion-restriction-in-the-brain-stem-and-hippocampus-a-clinical-report-of-selected-cases
#10
T Sartoretti, E Sartoretti, C Binkert, A Gutzeit, C Reischauer, D Czell, M Wyss, E Brüllmann, S Sartoretti-Schefer
Diffusion restriction is the morphologic hallmark of acute ischemic infarcts and excitotoxic brain injury in various cerebral pathologies. Diffusion restriction is visible as hyperintensity on DWI and as hypointensity on ADC maps. Due to the vicinity of multiple anatomic structures in the brain stem and hippocampus, very small lesions with diffusion restriction may result in severe clinical symptomatology, but these small lesions easily go undetected on standard cerebral DWI due to insufficient spatial resolution, T2* blurring, and image artifacts caused by susceptibility-related image distortions...
April 26, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29697165/automated-pixel-wise-brain-tissue-segmentation-of-diffusion-weighted-images-via-machine-learning
#11
Alexander Ciritsis, Andreas Boss, Cristina Rossi
The diffusion-weighted (DW) MR signal sampled over a wide range of b-values potentially allows for tissue differentiation in terms of cellularity, microstructure, perfusion, and T2 relaxivity. This study aimed to implement a machine learning algorithm for automatic brain tissue segmentation from DW-MRI datasets, and to determine the optimal sub-set of features for accurate segmentation. DWI was performed at 3 T in eight healthy volunteers using 15 b-values and 20 diffusion-encoding directions. The pixel-wise signal attenuation, as well as the trace and fractional anisotropy (FA) of the diffusion tensor, were used as features to train a support vector machine classifier for gray matter, white matter, and cerebrospinal fluid classes...
April 26, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29692518/transient-global-amnesia-diffusion-mri-findings
#12
Tarun P Jain, Ronak Patel, Yash Gawarikar
Introduction: Aim of this study is to identify and describe the MRI findings in patients with Transient Global Amnesia (TGA), specifically on Diffusion Weighted Imaging (DWI) sequence. Methods: MRI findings in 12 patients with clinical diagnosis of TGA were retrospectively analysed. MRI brain was performed with a 3T scanner on 11 patients and 1.5T scanner on 1 patient. DWI were acquired at B value of 1000 s/mm2 in 4 patients, 2000 s/mm2 in 2 patients and both 1000 and 2000 s/mm2 in 6 patients...
January 2018: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/29689135/intravenous-thrombolysis-in-unwitnessed-stroke-onset-mr-witness-trial-results
#13
Lee H Schwamm, Ona Wu, Shlee S Song, Lawrence L Latour, Andria L Ford, Amie W Hsia, Alona Muzikansky, Rebecca A Betensky, Albert J Yoo, Michael H Lev, Gregoire Boulouis, Arne Lauer, Pedro Cougo, William A Copen, Gordon J Harris, Steven Warach
OBJECTIVE: Most acute ischemic stroke (AIS) patients with unwitnessed symptom onset are ineligible for intravenous thrombolysis due to timing alone. Lesion evolution on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) correlates with stroke duration, and quantitative mismatch of diffusion-weighted MRI with FLAIR (qDFM) might indicate stroke duration within guideline-recommended thrombolysis. We tested whether intravenous thrombolysis ≤4.5 hours from the time of symptom discovery is safe in patients with qDFM in an open-label, phase 2a, prospective study (NCT01282242)...
April 24, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29682033/diagnostic-and-prognostic-capability-of-newer-magnetic-resonance-imaging-brain-sequences-in-diffuse-axonal-injury-patient
#14
Mayank Bansal, Virendra Deo Sinha, Juhi Bansal
Objectives: Diffuse axonal injury is one of the major causes of unconsciousness, profound neurologic deficits and persistent vegetative state after head trauma. In recent years, MR imaging has been gaining popularity as an adjunctive imaging method in patients with DAI. Our study aims to assess the relative diagnostic and prognostic capability of various MRI sequences. Patients and Methods: Retrospective observational study done in 1 year duration on 30 DAI patients...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682029/meningioma-consistency-correlation-between-magnetic-resonance-imaging-characteristics-operative-findings-and-histopathological-features
#15
Mahmoud Alyamany, Mohammad M Alshardan, Abdullah Abu Jamea, Nahid ElBakry, Lahbib Soualmi, Yasser Orz
Introduction: Intracranial meningiomas account for 30% of all primary intracranial tumors. Surgical resection remains the mainstay of the treatment for meningiomas. The magnetic resonance of intracranial meningiomas has been largely discussed in many reports of the radiological and neurosurgical literature. To date, a few studies have been attempted to differentiate the tumor characteristics of meningiomas based on magnetic resonance imaging (MRI) studies. Objective: The objective of the study is to evaluate the relationship between MRI signal characteristics of intracranial meningiomas and consistency of tumor using objective measures...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29657393/the-analysis-of-hippocampus-neuronal-density-ca1-and-ca3-after-ocimum-sanctum-ethanolic-extract-treatment-on-the-young-adulthood-and-middle-age-rat-model
#16
Dwi Liliek Kusindarta, Hevi Wihadmadyatami, Aris Haryanto
Aim: This study aimed to assess the changes in neuronal density in CA1 and CA3 regions in the hippocampus of young adulthood and middle age rat model after feeding by Ocimum sanctum ethanolic extract. Materials and Methods: In this research, 30 male Wistar rats consist of young to middle-aged rats were divided into three groups (3, 6, and 9 months old) and treated with a different dosage of O. sanctum ethanolic extract (0, 50, and 100 mg/kg b.w.) for 45 days. Furthermore, cresyl violet staining was performed to analyze hippocampus formation mainly in CA1 and CA3 area...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29627833/small-hyperintensities-in-the-area-of-the-perforating-arteries-in-patients-with-seizure
#17
Nobuyuki Izutsu, Yasunori Fujimoto, Naoaki Yamada, Ryuichiro Kajikawa, Kazuhiro Yoshimura, Munenori Nagashima, Akatsuki Wakayama, Toshiki Yoshimine
BACKGROUND/AIM: We previously observed spotty hyperintense lesions in the region of the perforating arteries on peri-ictal diffusion-weighted imaging (DWI); however, no report has formally described these findings. The aim of this study was to investigate focal intensities on peri-ictal DWI, and to evaluate the clinical significance of these lesions. METHODS: We conducted a retrospective review of 677 consecutive patients with seizure who completed peri-ictal DWI within 24 h after seizure onset...
April 6, 2018: European Neurology
https://www.readbyqxmd.com/read/29596475/sensitivity-of-different-mri-sequences-in-the-early-detection-of-melanoma-brain-metastases
#18
Katerina Deike-Hofmann, Daniel Thünemann, Michael O Breckwoldt, Daniel Schwarz, Alexander Radbruch, Alexander Enk, Martin Bendszus, Jessica Hassel, Heinz-Peter Schlemmer, Philipp Bäumer
BACKGROUND: After the emergence of new MRI techniques such as susceptibility- and diffusion-weighted imaging (SWI and DWI) and because of specific imaging characteristics of melanoma brain metastases (MBM), it is unclear which MRI sequences are most beneficial for detection of MBM. This study was performed to investigate the sensitivity of six clinical MRI sequences in the early detection of MBM. METHODS: Medical records of all melanoma patients referred to our center between November 2005 and December 2016 were reviewed for presence of MBM...
2018: PloS One
https://www.readbyqxmd.com/read/29588064/the-evaluation-of-the-effects-of-steroid-treatment-on-the-tumor-and-peritumoral-edema-by-dwi-and-mr-spectroscopy-in-brain-tumors
#19
Cahit Kural, Gokce Kaan Atac, Ozkan Tehli, Ilker Solmaz, Caglar Temiz, Irgen Hodaj, Yusuf Izci
OBJECTIVE: To investigate the effects of dexamethasone on brain tumor and peritumoral edema by different sequences of magnetic resonance imaging (MRI). MATERIALS AND METHODS: MRI was performed in 28 patients with brain tumor. Patients were divided into the 3 groups based on the histological diagnosis; Group I: high-grade glial tumor, Group II: low-grade glial tumor, and Group III: brain metastasis. The measurements of peritumoral edema volume and apparent diffusion coefficient (ADC) values were performed while the peak areas of cerebral metabolites were measured by spectroscopy in groups I and II...
March 13, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29582945/-spontaneous-parenchymal-intracranial-hemorrhage-a-diagnostic-challenge
#20
Ruth Eliahou, Auriel Eitan, Moshe Gomori, Jacob Sosna, Asaf Honig
Non-traumatic intracranial hemorrhage (ICH) is a devastating event associated with a high rate of morbidity and mortality. Patient age, hemorrhage location, number of foci, and underlying diseases are important clues to the etiology. Non-contrast head CT, given its availability and high sensitivity in detecting blood products, is frequently the first tool to readily detect ICH; however, different types of hemorrhages may share a common appearance on CT and the optimal therapeutic approach varies depending on etiology...
March 2018: Harefuah
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