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conjunctival carcinoma

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https://www.readbyqxmd.com/read/29910832/phase-i-ii-study-on-kilovoltage-surface-brachytherapy-in-conjunctival-cancer-preliminary-results
#1
Gustavo R Sarria, Gustavo J Sarria, Paola Fuentes Rivera, Mayer Zaharia, Solón Serpa, Mario Buitrago
Introduction: In ocular conjunctival carcinoma after surgery, adjuvant treatment has a role and kilovoltage surface brachytherapy opens a new door for the range of therapeutic options. Materials and methods: Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. The portable accelerator of 50-kV INTRABEAM (Carl Zeiss Meditec) was used, after local anaesthesia and blocking of ocular muscles movement...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29863543/conjunctival-squamous-neoplasia-staging-and-initial-treatment
#2
Claudine Bellerive, Jesse L Berry, Ashley Polski, Arun D Singh
PURPOSE: To evaluate the clinical relevance of the American Joint Committee on Cancer (AJCC) classification in the initial management of squamous neoplasia of the conjunctiva. METHODS: This retrospective study enrolled 95 histopathologically proven cases of treatment-naive conjunctival squamous neoplasia. Tumors were classified into 4 histological groups: conjunctival intraepithelial neoplasia (CIN) with mild dysplasia (grade 1/3), moderate dysplasia (grade 2/3), severe dysplasia (grade 3/3 or carcinoma in situ), and invasive squamous cell carcinoma (SCC)...
May 31, 2018: Cornea
https://www.readbyqxmd.com/read/29848037/ocular-human-papillomavirus-infections
#3
Mehenaz Hanbazazh, Kymberly A Gyure
CONTEXT: - Human papillomavirus (HPV) has a well-known role in the pathogenesis of squamous cell carcinoma and precursor lesions of the cervix, anogenital region, and head and neck, but its role in the development of squamous neoplasms of the eye, particularly the conjunctiva, remains unclear. OBJECTIVE: - To review recent evidence implicating HPV in the pathophysiology of ocular lesions. DATA SOURCES: - Published articles obtained from a PubMed search of the English literature were the primary sources for this review...
June 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29805827/treatment-and-pathology-of-an-unusual-large-carcinoma-of-the-conjunctiva
#4
Thomas Stahnke, Ngoy Kilangalanga, Steffi Knappe, Rudolf F Guthoff, Andreas Erbersdobler
Carcinoma of the conjunctiva is a malignant tumor which is mostly detected and surgically treated at an early stage because of medical or cosmetic problems. Exceptions of this rule may occur in developing countries, where patients do not have access to standard medical care systems. We report the case of a conjunctival carcinoma in an African patient with an unusually late presentation. Because of local medical shortcomings, and considering the severe, transmural inflammation of anterior ocular structures, an exenteration was performed although the orbit was not deeply involved with the tumor...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29795720/ruthenium-brachytherapy-for-intraocular-growth-of-a-conjunctival-squamous-cell-carcinoma-a-case-report
#5
Iwona Rospond-Kubiak, Wojciech Adamski, Kinga Sosnowska, Jarosław Kociȩcki, Andrzej Marszałek
The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC). In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal endothelium. The patient was treated with iridectomy, and after one month, ruthenium brachytherapy was applied. 4.5 years post-irradiation, the treated eye is painless, and no recurrence was noted. We advocate the use of ruthenium brachytherapy as an eye salvage treatment with an intraocular extension of conjunctival SCC...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29778279/outcomes-after-surgical-resection-of-lower-eyelid-tumors-and-reconstruction-using-a-nasal-chondromucosal-graft-and-an-upper-eyelid-myocutaneous-flap
#6
S Lemaître, C Lévy-Gabriel, L Desjardins, M González-Candial, S Gardrat, R Dendale, N Cassoux, B Couturaud
INTRODUCTION: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result. MATERIALS AND METHODS: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap...
May 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29750729/posterior-lamellar-reconstruction-of-the-lower-eyelid-with-a-gingivoalveolar-mucosal-graft
#7
Yahya Baltu
The anterior and posterior lamellae should be simultaneously reconstructed to repair the upper and lower eyelid's full thickness defects after resection of a malignant tumor. The author described a gingivoalveolar mucosal graft for posterior lamellar reconstruction of the lower eyelid. Between November 2014 and September 2017, 11 patients (6 women, 5 men; mean age 62.7 years) with 13 posterior lamellar defect of lower eyelid underwent reconstruction with gingivoalveolar mucosal graft. The defects ranged from 10 x 8 mm to 20 x 10 mm...
June 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29681840/intraoperative-adjunctive-mitomycin-c-and-cryotherapy-for-recurrent-conjunctival-papillary-sebaceous-carcinoma
#8
Natsuki Monai, Reiko Tanabu, Takayuki Gonome, Katsunori Yokoi, Satoshi Urushidate, Satoko Morohashi, Hideaki Hirai, Akira Kurose, Mitsuru Nakazawa
Purpose: To report a case of recurrent conjunctival papillary sebaceous carcinoma that was successfully treated by a combination of surgical resection, intraoperative topical mitomycin C application, and cryotherapy. Observations: A woman in her 80s developed a yellowish papillary tumor pedunculated from the surface of the upper palpebral tarsal conjunctiva in her left eye. She was histopathologically diagnosed as having sebaceous carcinoma by an excisional biopsy...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29675344/conjunctival-papilloma-clinical-features-outcome-and-factors-related-to-recurrence
#9
Yi-Ming Huang, Yu-Yun Huang, Hsin-Yu Yang, Chieh-Chih Tsai, Wei-Kuang Yu, Shu-Ching Kao, Hui-Chuan Kau, Catherine Jui-Ling Liu
PURPOSE: The purpose of the study was to evaluate the clinical features, treatment, and outcome of patients with conjunctival papilloma. MATERIALS AND METHODS: Twenty-two patients (22 eyes) with biopsy-proven conjunctival papilloma between January 2005 and January 2015 in a tertiary medical center were retrospectively reviewed. Clinical profiles, treatment, outcome, and factors related to recurrence were evaluated. RESULTS: There were 16 males (73%) and 6 females (27%), with a mean age of 47 years...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29577676/superficial-radiotherapy-as-a-treatment-alternative-for-recurrent-conjunctival-squamous-cell-carcinoma-a-case-study
#10
Amanda Edgar, Gretel Crutchfield, Nigel Anderson
This case study discusses the use of superficial radiotherapy (SXRT) in the treatment of recurrent conjunctival squamous cell carcinoma (SCC). Conjunctival SCC is often an aggressive cancer, with surgery the current standard of care. There is currently limited literature on alternative treatment options to treat conjunctival SCC recurrences that enable ocular function preservation. Furthermore, the use of SXRT in this setting is not well-reported. Technical feasibility, practical limitations and potential side effects of SXRT (in comparison to other treatment options) are discussed in this case study...
March 25, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29562930/telomerase-promoter-mutations-in-human-immunodeficiency-virus-related-conjunctiva-neoplasia
#11
Noemy Starita, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HIV on the occurrence of telomerase reverse transcriptase (TERT) promoter mutations among a cohort of conjunctiva neoplasia Ugandan patients. METHODS: Telomerase reverse transcriptase promoter mutations were searched in 72 conjunctiva neoplasia cases, comprising SCC and intraepithelial neoplasia grade 1-3 (CIN1-3), as well as in 53 conjunctiva normal tissues and in 24 HIV-related Kaposi sarcoma...
March 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29559813/ocular-surface-squamous-neoplasia-in-hiv-infected-patients-current-perspectives
#12
REVIEW
Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki
Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure...
2018: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/29533279/human-papillomavirus-driven-squamous-lesions-high-risk-genotype-found-in-conjunctival-papillomas-dysplasia-and-carcinoma
#13
Amanda B Moyer, Jordan Roberts, Randall J Olsen, Patricia Chévez-Barrios
BACKGROUND: Human papillomavirus (HPV) is a causative agent for intraepithelial squamous neoplasms, particularly on mucosal surfaces. HPV has a well-established association with squamous cell carcinoma (SCC) of the oropharynx and genital tract, and recent studies suggest a potential role in ocular and periocular squamous neoplasms. Multiple high-risk HPV genotypes are associated with histologically similar squamous neoplasms, and some HPV genotypes have been differentially associated with high- or low-grade lesions...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29489511/loss-of-prb-in-conjunctival-squamous-cell-carcinoma-a-predictor-of-poor-prognosis
#14
Sheetal Chauhan, Seema Sen, Anjana Sharma, Seema Kashyap, Radhika Tandon, Neelam Pushker, Murugesan Vanathi, Shyam S Chauhan
Conjunctival squamous cell carcinoma (SCC) is the most common tumor of conjunctival epithelium. It is associated with risk of permanent visual impairment and has the capability to recur, metastasize, and cause death. Deregulation of cell cycle control has been reported in a number of malignancies. The aim of the present study was to assess expression of G1/S cell cycle regulatory proteins [retinoblastoma protein (pRb)/P16/cyclin D1] in conjunctival SCC. Forty-four prospective cases of conjunctival SCC from a tertiary eye care referral center in northern India were included in this study...
February 27, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29475731/-adjuvant-contact-radiotherapy-for-conjunctival-malignancies-preliminary-results-of-a-series-of-14-patients-treated-with-the-papillon-50-machine
#15
R Coquard, A M N'Guyen, T Mathis, F Josserand-Pietri, M Khodri, G Largeron, N Barbet, J D Grange
PURPOSE: To evaluate the results of an adjuvant contact irradiation using 50kV photons after resection of conjunctival malignancies. MATERIALS AND METHOD: From 2012 to 2014, 14 patients (male: nine; female: five) have been treated by contact irradiation after resection of a malignant tumor of the conjunctiva (melanoma: five patients; malignant fibrous histiocytoma: one patient; carcinoma: eight patients) The treatment was performed using the Papillon 50 machine (Ariane)...
April 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29380787/primary-squamous-cell-carcinoma-arising-from-palpebral-conjunctiva-a-rare-presentation
#16
H Vijaya Pai, Divya Handa, J Padma Priya
Squamous cell carcinoma (SCC) of the conjunctiva usually arises from the limbal conjunctiva. Rarely, it can arise from the palpebral conjunctiva. We report a case of primary conjunctival SCC of the palpebral conjunctiva which was treated successfully.
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29250968/-ocular-surface-squamous-neoplasia
#17
REVIEW
Gábor Tóth, Gábor László Sándor, Andrea Gyenes, Jeannette Tóth, Berthold Seitz, Zoltán Zsolt Nagy, Nóra Szentmáry
To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134185/infiltrative-intraocular-conjunctival-squamous-cell-carcinoma-after-local-resection-and-brachytherapy-clinical-and-pathological-findings
#18
Magnolia Trinidad Cano-Suárez, María Antonia Saornil-Álvarez, Ciro García-Álvarez, Francisco López-Lara, Jesús María Frutos-Baraja, Elena García-Lagarto
A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctival squamous cell carcinoma (CSCC). Excisional biopsy showed a well-differentiated CSCC with positive margins and the patient underwent adjuvant brachytherapy. Six weeks later, examination of the anterior segment revealed cells in the anterior chamber and a neurotrophic corneal ulcer with corneal perforation. Considering the high suspicion of intraocular invasion of CSCC, the left eye was enucleated...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29111820/identification-of-feeder-vessels-in-ocular-surface-neoplasia-using-indocyanine-green-angiography
#19
Matthias Brunner, Bernhard Steger, Vito Romano, Martin Hodson, Yalin Zheng, Heinrich Heimann, Stephen B Kaye
PURPOSE: To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS: Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of the bulbar conjunctiva were included. Patients underwent anterior segment optical coherence tomography, ICGA, and color photography for the evaluation of the thickness, location, number, and diameter of afferent and efferent vessels of the lesions...
February 2018: Current Eye Research
https://www.readbyqxmd.com/read/29039986/orbital-exenteration-institutional-review-of-evolving-trends-in-indications-and-rehabilitation-techniques
#20
Hayyam Kiratli, İrem Koç
PURPOSE: To determine the changes in indications for orbital exenteration over 20 years and to assess its impact on patient survival. Evolving techniques of rehabilitation of the orbit in our institution were also evaluated. METHODS: This was a retrospective review of hospital records of patients who underwent orbital exenteration from 1995 to 2015 in a tertiary care center. Data extracted included primary location of the tumor, preoperative treatments, interval between initial diagnosis and exenteration, status of surgical margins, presence of metastatic disease, and postoperative survival...
October 17, 2017: Orbit
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