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conjunctival carcinoma

Swathi Kaliki, Suzanne K Freitag, James Chodosh
PURPOSE: To describe clinical presentation and histopathological features of a nodulo-ulcerative variant of ocular surface squamous neoplasia (OSSN). METHODS: Retrospective study. RESULTS: Six patients were identified with a nodulo-ulcerative variant of OSSN. Mean age at presentation was 56 years. One patient was immunosuppressed because of human immunodeficiency virus infection. The initial misdiagnosis was necrotizing scleritis/sclerokeratitis (n = 4), intraepithelial neoplasia (n = 1), and chalazion (n = 1)...
October 5, 2016: Cornea
Carol L Shields, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Alexzandra M Douglass, Kareem Sioufi, Emil A T Say, Jerry A Shields
PURPOSE: To evaluate frequency of conjunctival tumors in all ages and compare benign versus (vs) malignant counterparts. DESIGN: Retrospective series. METHODS: Setting: Tertiary referral center STUDY POPULATION: 5002 patients OBSERVATION: Clinical features MAIN OUTCOME MEASURE: Differentiation benign from malignant counterparts RESULTS: The tumor was benign (52%), premalignant (18%), or malignant (30%). Malignant tumors included melanoma (12%), squamous cell carcinoma (9%), lymphoma (7%), and others...
October 7, 2016: American Journal of Ophthalmology
Kim Vieira Kayat, Paulo Elias Correa Dantas, Sérgio Felberg, Maria Antonieta Galvão, Mauro Ajaj Saieg
PURPOSE: Surface tumors of the eye comprise an ample spectrum of diseases with various clinical manifestations. Diagnosis has been traditionally achieved through core biopsies, but cytology is an innovative, fast, and minimally invasive method. The objective of this study was to investigate the use of exfoliative cytology as an alternative method for the detection of ocular surface squamous neoplasm (OSSN). METHODS: Exfoliative cytology of the lesions was performed by collecting smears using plastic brushes followed by smearing the cells onto slides and subsequently fixing them in 90% alcohol...
September 21, 2016: Cornea
Marian Pauly, Mekhla Naik, Anantharaman Giridhar
No abstract text is available yet for this article.
September 7, 2016: Ophthalmic Plastic and Reconstructive Surgery
Alexander Martin-Odoom, Evelyn Yayra Bonney, Derek Kofi Opoku
BACKGROUND: Patients infected with human immunodeficiency virus (HIV) usually develop some form of ocular complication in the different segments of the eye due to immune deficiency. In Ghana, data regarding ocular complications among HIV/AIDS patients is scarce. This study investigated the occurrence of ocular complications in HIV infected patients undergoing antiretroviral therapy at the Agogo Presbyterian Hospital in the Ashanti Region of Ghana. METHODS: Blood samples were taken from 100 confirmed HIV infected patients...
2016: BMC Ophthalmology
Gokhan Ozge, Yusuf Uysal, Osman Melih Ceylan, Onder Onguru, Fatih Mehmet Mutlu
Keratoacanthomas rarely occur in the conjunctiva. We report a case of a 24-year-old man with a rapidly growing conjunctival mass. The tumor was excised with a safety margin to exclude squamous cell carcinoma and was histopathologically diagnosed as a keratoacanthoma. There has been no recurrence over 2 years of follow-up. To the best of our knowledge, he is the youngest patient to be diagnosed with conjunctival keratoacanthoma who had no known risk factors such as skin disorders, trauma, surgery, or infection...
May 2016: Arquivos Brasileiros de Oftalmologia
Muge Coban-Karatas, Nebil Bal, Rana Altan-Yaycioglu, Aysen Terzi
An 85-year-old male presented with painless bulging lesion over the cornea. Clinical history, diagnostic imaging studies, and histopathologic sections were evaluated. The patient clinically displayed an vascularized conjunctival lesion located at the superior bulbar conjunctiva with extension onto cornea covering 2/3 of his pupillary aperture superiorly. His visual acuity was counting fingers at 4 m. The patient underwent a total excision of the lesion including conjunctival and corneal parts. Histopathologic evaluation revealed spindle cell carcinoma which involves the whole conjunctival squamous epithelium with significant polarity loss, nuclear enlargement with hyperchromasia and pleomorphism, and mitotic activity...
May 2016: Indian Journal of Ophthalmology
Ali Riza Cenk Celebi, Hayyam Kiratli, Figen Soylemezoglu
The purpose of the present study was to assess the role of hedgehog signaling pathway in the carcinogenesis of eyelid skin and conjunctival epithelial malignant tumors. The study was conducted on specimens from 41 patients with cutaneous eyelid basal cell carcinoma, 22 with bulbar conjunctival squamous cell carcinoma, 12 with bulbar conjunctival intraepithelial neoplasia. Major molecules of Hedgehog signaling pathway (Sonic Hedgehog [Shh] and Patched-1 [Ptch-1] and Glioma-associated oncogene [Gli-1]) were evaluated in paraffin-embedded tissue specimens using immunohistochemical staining...
July 2016: Oncology Letters
Alfonso Iovieno, Caterina Longo, Mariacarla De Luca, Simonetta Piana, Luigi Fontana, Moira Ragazzi
PURPOSE: To evaluate the potential use of fluorescence confocal microscopy (FCM) for ex vivo diagnosis and excision margin assessment of conjunctival neoplasms. DESIGN: Validity study. METHODS: setting: Single institution. PARTICIPANTS: Consecutive patients with clinically suspicious conjunctival lesions. INTERVENTION: Conjunctival lesions were excised in toto using a standard "no-touch technique" by a single surgeon (A...
August 2016: American Journal of Ophthalmology
Austen N Knapp, Wasim A Samara, Carol L Shields, Jerry A Shields, Ralph C Eagle
An 8-year-old healthy boy underwent surgery for excision of a painless, enlarging vascularized conjunctival tumor. Histopathology disclosed a mass comprised of interweaving spindle cells and scattered histiocytes in a fibrous matrix, consistent with benign fibrous histiocytoma. This rare tumor can resemble several conditions, including scleritis/episcleritis, inflamed pterygium, juvenile xanthogranuloma, foreign body granuloma, solitary fibrous tumor, amelanotic melanoma, and squamous cell carcinoma.
August 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Ignacio Goñi Espildora, Jaime Jans, Militza Petric Guajardo, Manuel Manzor Veliz, Juan C Flores Pérez, Gonzalo Varas Marchant, Pablo Muñoz-Schuffenegger, Pablo Zoroquiain Vélez
Squamous cell carcinoma of the conjunctiva is the most frequent malignant tumor of the ocular surface. It is a rare disease with an incidence of 0.13 to 1.9 per 100,000 inhabitants, mainly affecting individuals between 50 and 75 years of age. It tends to have a slow, non-aggressive course. Treatment depends on the extent of the tumor. If there is intraocular involvement, enucleation is indicated, and in the presence of extraocular involvement the orbital exenteration is the standard treatment. We report and discuss the case of an 82 year old male patient having a conjunctival squamous cell carcinoma with intra and extraocular involvement, together with a review of the literature...
2016: Medwave
Maria J Suarez, Roxana Rivera-Michlig, Sander Dubovy, Fausto J Rodriguez
BACKGROUND: Patients with xeroderma pigmentosum (XP) are strongly predisposed to the development of numerous cutaneous cancers. However, the extent of ocular pathology in these patients has not been adequately studied. METHODS: We conducted a retrospective study of tumors involving the ocular surface and ocular adnexa from 6 XP patients. Histopathological evaluation and immunohistochemistry was performed using antibodies directed against the most common mutated proteins in XP (XPA, XPC, and XPD)...
December 2015: Ocular Oncology and Pathology
Madhura G Joag, Anita Gupta, Anat Galor, Sander R Dubovy, Jose Antonio Bermudez-Magner, Jianhua Wang, Carol L Karp
OBJECTIVE: To describe the clinical presentation, diagnostic imaging, and treatment options of conjunctival intraepithelial neoplasia (CIN) with mucoepidermoid differentiation, an in situ stage of mucoepidermoid carcinoma of the conjunctiva (MCC). RESULTS: We report the case of an 86-year-old man presenting with a subtle limbal lesion that had only mild erythema and elevation. Based on a few atypical clinical features and an abnormal ultrahigh-resolution optical coherence tomography (UHR OCT), an incisional biopsy was performed revealing CIN with mucoepidermoid differentiation...
June 2015: Ocular Oncology and Pathology
Katharine S Sears, Ian G Rennie, Hardeep Singh Mudhar
PURPOSE: To describe the clinical and histopathological features of a 61-year-old male with a history of eczema, asthma and schizophrenia on long-term chlorpromazine medication, who developed a unilateral limbal tumour in association with bilateral melanosis. PROCEDURES: The patient was referred for a routine cataract assessment, and an incidental pink gelatinous limbal lesion was detected on the left side, associated with bilateral speckled brown conjunctival pigmentation...
June 2015: Ocular Oncology and Pathology
C R Berete, L Desjardins, L J Kouassi, F Coulibaly, K S Kouakou, K Gbe, A Fanny
PURPOSE: To describe the epidemiological and clinical parameters of conjunctival squamous cell carcinomas and their association with HIV-AIDS in the ophthalmology department of the university hospital of Treichville. PATIENTS ET METHODS: This is a prospective and descriptive cross sectional study carried out in the ophthalmology department of the university hospital of Treichville from July 2007 to June 2011. Twenty-six (26) patients who were selected presented with a tumor of the globe and/or adnexa...
May 2016: Journal Français D'ophtalmologie
Pablo Zoroquiain, Dana Faingold, Sarah Algahmdi, Natalia Vila, Patrick Logan, Debra-Meghan Sanft, Ana Beatriz Toledo Dias, Sultan Aldrees, Vasco Bravo-Filho, Julia Burnier, Miguel N Burnier
OBJECTIVES: The aim of this study was to evaluate heat shock protein 90 (HSP90) expression in squamous lesions (SLs) and to assess its diagnostic value for different lesions within the SL spectrum. METHODS: A total of 70 conjunctival SLs, including 19 papillomas, 22 cases of conjunctival intraepithelial neoplasia (ConINs) I, 11 cases of ConIN II, six cases of ConIN III, and 12 squamous carcinomas (sqCAs), were evaluated using the German immunoreactive score against HSP90...
March 2016: American Journal of Clinical Pathology
Kazuomi Hanada, Noriko Nishikawa, Naoyuki Miyokawa, Akitoshi Yoshida
The aim of the study is to evaluate the long-term clinical results of amniotic membrane transplantation (AMT) combined with mitomycin C (MMC) for reconstruction of conjunctival defects created during the excision of ocular surface squamous neoplasia (OSSN). Eight consecutive eyes of seven patients (five males and two females; mean age, 64 ± 19 years) treated by one surgeon (KH) were included in this study. AMT was performed after excision of a mass region, along with 0.04 % MMC treatment for the exposed sclera...
April 9, 2016: International Ophthalmology
Shilpa J Desai, Noelle L Pruzan, Michael J Geske, Bennie H Jeng, Michele M Bloomer, M Reza Vagefi
Two cases of biopsy-proven conjunctival squamous cell carcinoma (SCC) that developed local and regional spread are described. The cases involved a 65-year-old woman and a 79-year-old man who were initially treated at outside institutions for SCC of the conjunctiva. The patients did not have a history of immune compromise. The female patient presented with direct extension into the lacrimal gland but deferred recommended exenteration. Despite eventual exenteration, she developed metastasis to a neck node 6 months later, which was treated with radiotherapy...
April 6, 2016: Eye & Contact Lens
Bita Esmaeli, Vivian T Yin, Ehab Y Hanna, Merrill S Kies, William N William, Diana Bell, Steven J Frank
BACKGROUND: We analyzed local control and early ocular toxicity after eye-sparing management of lacrimal gland carcinoma. METHODS: For consecutive patients with lacrimal gland carcinoma treated during 2007 to 2014, we reviewed tumor characteristics, treatment details, ocular toxic effects, and recurrence. RESULTS: Twenty patients, median age 55 years, were treated for lacrimal gland carcinoma during the study period; 11 had globe-sparing surgery...
August 2016: Head & Neck
Eva Diltoer, Marcel P M Ten Tusscher
A 72-year-old woman presented with a painful right eye. A few weeks before, she had noticed a red, swollen area in the conjunctiva of the same eye. On slit lamp examination, it appeared as chemosis and vascular injection; artificial tears were prescribed. A month later, a firm mass developed on the superotemporal orbital rim, in the area of the lacrimal gland. A CT scan revealed infiltrative structures in both the left and right orbit, with contrast staining in the right lacrimal gland and near the left optic nerve...
September 2015: Case Reports in Ophthalmology
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