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conjunctival carcinoma

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https://www.readbyqxmd.com/read/29675344/conjunctival-papilloma-clinical-features-outcome-and-factors-related-to-recurrence
#1
Yi-Ming Huang, Yu-Yun Huang, Hsin-Yu Yang, Chieh-Chih Tsai, Wei-Kuang Yu, Shu-Ching Kao, Hui-Chuan Kau, Catherine Jui-Ling Liu
PURPOSE: The purpose of the study was to evaluate the clinical features, treatment, and outcome of patients with conjunctival papilloma. MATERIALS AND METHODS: Twenty-two patients (22 eyes) with biopsy-proven conjunctival papilloma between January 2005 and January 2015 in a tertiary medical center were retrospectively reviewed. Clinical profiles, treatment, outcome, and factors related to recurrence were evaluated. RESULTS: There were 16 males (73%) and 6 females (27%), with a mean age of 47 years...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29577676/superficial-radiotherapy-as-a-treatment-alternative-for-recurrent-conjunctival-squamous-cell-carcinoma-a-case-study
#2
Amanda Edgar, Gretel Crutchfield, Nigel Anderson
This case study discusses the use of superficial radiotherapy (SXRT) in the treatment of recurrent conjunctival squamous cell carcinoma (SCC). Conjunctival SCC is often an aggressive cancer, with surgery the current standard of care. There is currently limited literature on alternative treatment options to treat conjunctival SCC recurrences that enable ocular function preservation. Furthermore, the use of SXRT in this setting is not well-reported. Technical feasibility, practical limitations and potential side effects of SXRT (in comparison to other treatment options) are discussed in this case study...
March 25, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29562930/telomerase-promoter-mutations-in-human-immunodeficiency-virus-related-conjunctiva-neoplasia
#3
Noemy Starita, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection. We analyzed the role of HIV on the occurrence of telomerase reverse transcriptase (TERT) promoter mutations among a cohort of conjunctiva neoplasia Ugandan patients. METHODS: Telomerase reverse transcriptase promoter mutations were searched in 72 conjunctiva neoplasia cases, comprising SCC and intraepithelial neoplasia grade 1-3 (CIN1-3), as well as in 53 conjunctiva normal tissues and in 24 HIV-related Kaposi sarcoma...
March 21, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29559813/ocular-surface-squamous-neoplasia-in-hiv-infected-patients-current-perspectives
#4
REVIEW
Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki
Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure...
2018: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/29533279/human-papillomavirus-driven-squamous-lesions-high-risk-genotype-found-in-conjunctival-papillomas-dysplasia-and-carcinoma
#5
Amanda B Moyer, Jordan Roberts, Randall J Olsen, Patricia Chévez-Barrios
BACKGROUND: Human papillomavirus (HPV) is a causative agent for intraepithelial squamous neoplasms, particularly on mucosal surfaces. HPV has a well-established association with squamous cell carcinoma (SCC) of the oropharynx and genital tract, and recent studies suggest a potential role in ocular and periocular squamous neoplasms. Multiple high-risk HPV genotypes are associated with histologically similar squamous neoplasms, and some HPV genotypes have been differentially associated with high- or low-grade lesions...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29489511/loss-of-prb-in-conjunctival-squamous-cell-carcinoma-a-predictor-of-poor-prognosis
#6
Sheetal Chauhan, Seema Sen, Anjana Sharma, Seema Kashyap, Radhika Tandon, Neelam Pushker, Murugesan Vanathi, Shyam S Chauhan
Conjunctival squamous cell carcinoma (SCC) is the most common tumor of conjunctival epithelium. It is associated with risk of permanent visual impairment and has the capability to recur, metastasize, and cause death. Deregulation of cell cycle control has been reported in a number of malignancies. The aim of the present study was to assess expression of G1/S cell cycle regulatory proteins [retinoblastoma protein (pRb)/P16/cyclin D1] in conjunctival SCC. Forty-four prospective cases of conjunctival SCC from a tertiary eye care referral center in northern India were included in this study...
February 27, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29475731/-adjuvant-contact-radiotherapy-for-conjunctival-malignancies-preliminary-results-of-a-series-of-14-patients-treated-with-the-papillon-50-machine
#7
R Coquard, A M N'Guyen, T Mathis, F Josserand-Pietri, M Khodri, G Largeron, N Barbet, J D Grange
PURPOSE: To evaluate the results of an adjuvant contact irradiation using 50kV photons after resection of conjunctival malignancies. MATERIALS AND METHOD: From 2012 to 2014, 14 patients (male: nine; female: five) have been treated by contact irradiation after resection of a malignant tumor of the conjunctiva (melanoma: five patients; malignant fibrous histiocytoma: one patient; carcinoma: eight patients) The treatment was performed using the Papillon 50 machine (Ariane)...
February 20, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29380787/primary-squamous-cell-carcinoma-arising-from-palpebral-conjunctiva-a-rare-presentation
#8
H Vijaya Pai, Divya Handa, J Padma Priya
Squamous cell carcinoma (SCC) of the conjunctiva usually arises from the limbal conjunctiva. Rarely, it can arise from the palpebral conjunctiva. We report a case of primary conjunctival SCC of the palpebral conjunctiva which was treated successfully.
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29250968/-ocular-surface-squamous-neoplasia
#9
REVIEW
Gábor Tóth, Gábor László Sándor, Andrea Gyenes, Jeannette Tóth, Berthold Seitz, Zoltán Zsolt Nagy, Nóra Szentmáry
To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134185/infiltrative-intraocular-conjunctival-squamous-cell-carcinoma-after-local-resection-and-brachytherapy-clinical-and-pathological-findings
#10
Magnolia Trinidad Cano-Suárez, María Antonia Saornil-Álvarez, Ciro García-Álvarez, Francisco López-Lara, Jesús María Frutos-Baraja, Elena García-Lagarto
A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctival squamous cell carcinoma (CSCC). Excisional biopsy showed a well-differentiated CSCC with positive margins and the patient underwent adjuvant brachytherapy. Six weeks later, examination of the anterior segment revealed cells in the anterior chamber and a neurotrophic corneal ulcer with corneal perforation. Considering the high suspicion of intraocular invasion of CSCC, the left eye was enucleated...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29111820/identification-of-feeder-vessels-in-ocular-surface-neoplasia-using-indocyanine-green-angiography
#11
Matthias Brunner, Bernhard Steger, Vito Romano, Martin Hodson, Yalin Zheng, Heinrich Heimann, Stephen B Kaye
PURPOSE: To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS: Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of the bulbar conjunctiva were included. Patients underwent anterior segment optical coherence tomography, ICGA, and color photography for the evaluation of the thickness, location, number, and diameter of afferent and efferent vessels of the lesions...
February 2018: Current Eye Research
https://www.readbyqxmd.com/read/29039986/orbital-exenteration-institutional-review-of-evolving-trends-in-indications-and-rehabilitation-techniques
#12
Hayyam Kiratli, İrem Koç
PURPOSE: To determine the changes in indications for orbital exenteration over 20 years and to assess its impact on patient survival. Evolving techniques of rehabilitation of the orbit in our institution were also evaluated. METHODS: This was a retrospective review of hospital records of patients who underwent orbital exenteration from 1995 to 2015 in a tertiary care center. Data extracted included primary location of the tumor, preoperative treatments, interval between initial diagnosis and exenteration, status of surgical margins, presence of metastatic disease, and postoperative survival...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29018015/chronic-red-eye-a-masquerade-of-advanced-neoplastic-disease
#13
Joana Providência, Filipa Ponces, Guilherme Castela, Joaquim Murta
A 42-year-old woman presented with chronic history of left red eye for more than 12 months, treated with difference topical medication but without response. Ocular external examination demonstrated a firm palpable mass in the medial portion of the lower eyelid and slit-lamp evaluation of the lesion showed an ulcerated conjunctival nodule, keratin secretor. CT of the orbits revealed left-sided orbital mass located anteriorly, inferiorly and medially in the orbit, adjacent to the globe and orbit walls. Incisional biopsy of the lesion was consistent with invasive squamous cell carcinoma of the conjunctiva...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28954025/surgical-amniotic-membrane-transplantation-after-conjunctival-and-limbal-tumor-excision
#14
Seniz Engur Goktas, Yasemin Katircioglu, Tuba Celik, Firdevs Ornek
Purpose: To evaluate the clinical results of patients treated by amniotic membrane transplantation (AMT) following excision of conjunctival and limbal tumors. Methods: A total of 14 eyes of 14 patients who underwent AMT after total lesion-free tumor excision and perilesional cryotherapy were evaluated. Results: The excised tumors comprised 7 conjunctival intraepithelial neoplasia, 5 conjunctival nevus, 1 primary acquired melanosis, and 1 squamous cell carcinoma...
July 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28898915/-current-therapies-in-superficial-malignant-tumors
#15
Simone Luisa Scholz, Anja Eckstein, Dirk Dekowski, Joachim Esser, Henrike Westekemper, Klaus P Steuhl
This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences.Basal cell carcinoma is the most common tumor of the periocular skin, divided into three subtypes (nodular, superficial and morphea)...
September 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28835829/conjunctival-leiomyosarcoma-a-fairly-common-tumour-in-an-uncommon-site
#16
Reubina Wadee
BACKGROUND: Leiomyosarcomas of soft tissue are malignant tumours that are not infrequently encountered in clinical medicine and histopathology. Such sarcomas of the eye are, however, a rare occurrence. PURPOSE: Herein, the histopathological features of a case of conjunctival leiomyosarcoma are described. A 38-year-old HIV-positive male, who was otherwise fit and healthy, presented with redness of his right eye and a mass of the conjunctiva. Clinically, he did not have any soft-tissue masses elsewhere in the body...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/28820163/sympathetic-ophthalmia-related-to-conjunctival-invasive-squamous-cell-carcinoma
#17
Inês Leal, David Cordeiro Sousa, Cláudia Loureiro, Ana Fonseca
Sympathetic ophthalmia (SO) is a rare, diffuse, bilateral, and granulomatous nonnecrotizing panuveitis that may follow intraocular penetrating trauma. Our aim is to report a rare case of SO following orbital exenteration. Orbital exenteration was performed on a 48-year-old african female due to conjunctival keratinizing squamous cell carcinoma with intraocular involvement of the left eye. Five days after the uneventful procedure, the patient presented signs and symptoms compatible with SO. Key differential diagnoses were excluded, and prompt and aggressive immunosuppression was started with a favourable but slow clinical response...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28741159/sebaceous-gland-carcinoma-of-the-ocular-adnexa-variability-in-clinical-and-histological-appearance-with-analysis-of-immunohistochemical-staining-patterns
#18
Eva Janine Schmitz, Martina C Herwig-Carl, Frank G Holz, Karin U Loeffler
PURPOSE: The purpose of the study was to evaluate the characteristics of sebaceous gland carcinoma (SGC) of the ocular adnexae, which is due to a high variability in clinical, histological and immunohistochemical characteristics often challenging to diagnose. METHODS: Records of six patients with SGC were reviewed, who underwent surgical excision and who were histologically diagnosed with SGC. For comparison, there were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC)...
November 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28690718/-conjunctival-carcinoma-in-situ-a-rare-lesion-that-should-not-be-ignored
#19
Rim Limaiem, Faten Limaiem
No abstract text is available yet for this article.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28622197/bilateral-hpv-positive-squamous-cell-carcinoma-in-situ-of-conjunctiva
#20
Rebecca S George, Darrell R Lewis, Curtis W Archibald, Godfrey Heathcote
A 45 year-old woman presented with blurred vision and irritation of the left eye. Clinical examination revealed a superior palpebral conjunctival lesion consistent with a diagnosis of papilloma. She was lost to follow up despite repeated attempts to schedule a biopsy, and presented again after an extended period with bilateral disease. Subsequent biopsy confirmed bilateral squamous cell carcinoma in situ which was human papilloma virus-16 positive by molecular testing. She declined further treatment; during the subsequent year, the lesions extended across the bulbar conjunctiva bilaterally...
January 2018: Ophthalmic Plastic and Reconstructive Surgery
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