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conjunctival melanoma

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https://www.readbyqxmd.com/read/27898616/the-role-for-sentinel-lymph-node-biopsy-in-the-management-of-conjunctival-melanoma
#1
Jeanie Ling, Robert Tauscher, Viraj Mehta, Matthew Zhang, Anthony Daniels, Sahar Kohanim
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27893585/conjunctival-melanoma-responsive-to-combined-systemic-braf-mek-inhibitors
#2
Lora R Dagi Glass, Donald P Lawrence, Frederick A Jakobiec, Suzanne K Freitag
This report demonstrates a unique case of conjunctival melanoma harboring a BRAF V600E mutation responsive to systemic therapy with BRAF and MEK inhibitors. While systemic therapy would not be appropriate in patients with local disease alone, it may act therapeutically in cases of higher stage ocular surface and eyelid melanoma.
November 23, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27869370/conjunctival-malignant-melanoma-in-denmark-epidemiology-treatment-and-prognosis-with-special-emphasis-on-tumorigenesis-and-genetic-profile
#3
Ann-Cathrine Larsen
No abstract text is available yet for this article.
December 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27843900/separate-primary-melanomas-of-the-bulbar-conjunctiva-and-eyelid-skin-clinical-implications-of-multiple-primary-melanomas
#4
Frances A Jacinto, George H Fisher, Edgar M Espana, Ilya M Leyngold, Curtis E Margo
PURPOSE: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. METHODS: This article offers a clinicopathological correlation with a review of the relevant literature. RESULTS: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27832282/conjunctival-melanoma-in-a-black-patient
#5
Stéphanie Lemaitre, Paul Fréneaux, Nathalie Cassoux
No abstract text is available yet for this article.
November 10, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27775232/sentinel-lymph-node-biopsy-for-ocular-adnexal-melanoma
#6
Margaret L Pfeiffer, Omar K Ozgur, Jeffrey N Myers, Andrew Peng, Jing Ning, Mark E Zafereo, Sudip Thakar, Bradley Thuro, Victor G Prieto, Merrick I Ross, Bita Esmaeli
BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27760645/-the-clinical-and-histopathological-analysis-of-2-053-cases-of-conjunctival-neoplasms
#7
J J Huang, B Li, Q F Liang, X L Xu, F Gao, Z B Zhang
Objective: We aimed to identify and describe the clinical and histopathologic characteristics of conjunctival neoplasms. Methods: Retrospective case series study. We collected and analyzed the clinical and histopathologic data of the conjunctival neoplastic specimens including the age, gender, and histopathologic diagnosis of all patients obtained from Beijing Tongren Eye Center between October 2003 and October 2015. All the pathology diagnosis results were divided into two categories which were benign and malignant tumors, according to Shields histopathological classification methods and the pathology diagnosis results in our department...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27725148/conjunctival-tumors-in-5002-cases-comparative-analysis-of-benign-versus-malignant-counterparts-the-2016-james-d-allen-lecture
#8
Carol L Shields, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Alexzandra M Douglass, Kareem Sioufi, Emil A T Say, Jerry A Shields
PURPOSE: To evaluate frequency of conjunctival tumors in all ages and compare benign vs malignant counterparts. DESIGN: Retrospective series. METHODS: setting: Tertiary referral center. STUDY POPULATION: Total of 5002 patients. OBSERVATION: Clinical features. MAIN OUTCOME MEASURE: Differentiation of benign from malignant counterparts. RESULTS: The tumor was benign (52%), premalignant (18%), or malignant (30%)...
January 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27662198/immune-checkpoint-inhibitors-for-treatment-of-metastatic-melanoma-of-the-orbit-and-ocular-adnexa
#9
Joshua Ford, Bradley A Thuro, Sudip Thakar, Wen-Jen Hwu, Karina Richani, Bita Esmaeli
Programmed cell death 1 (PD-1) inhibitors are members of a new class of drugs known as immune checkpoint inhibitors and have proven efficacy in the treatment of metastatic melanoma. Herein, the authors report the use of nivolumab and pembrolizumab, 2 recently Food and Drug Administration-approved PD-1 inhibitors, in 3 patients: 1 with metastatic conjunctival melanoma and 2 with metastatic cutaneous melanoma and orbital involvement. The patients' metastatic disease responded well to drug treatment. As of this writing, 2 patients have completed therapy and remain disease free at least 1 year after treatment completion; the other patient is still receiving treatment, and his orbital disease is responding...
September 21, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27606149/melanocytic-nevus-of-the-tarsal-conjunctiva
#10
Bülent Yazıcı, Ayşe Dolar Bilge, Ayşe Yağcı, Faisal Naqadan, Filiz Altıntepe
BACKGROUND: Melanocytic nevus is a rare occurrence in the tarsal conjunctiva and only 7 well-described cases have been reported previously in the English literature. CASE REPORT: The medical records of 4 patients with tarsal conjunctival melanocytic nevus were reviewed, together with the relevant literature. All patients (3 women and 1 man; age range: 17 - 40 years) had been referred with a suspicion of melanoma. There was one tarsal nevus in the lower eyelid in 3 patients and 2 nevi in the upper eyelid in 1 patient...
July 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27548891/microrna-expression-profile-in-conjunctival-melanoma
#11
Ann-Cathrine Larsen, Lauge H Mikkelsen, Rehannah Borup, Katalin Kiss, Peter B Toft, Christian von Buchwald, Sarah E Coupland, Jan U Prause, Steffen Heegaard
PURPOSE: Conjunctival melanoma (CM) is a rare disease associated with considerable mortality. As opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear. The purpose of this study was to identify tumor-specific and prognostic microRNA (miRNA) in CM and to compare the miRNA profile with that of MM. METHODS: Using microarray analysis (Affymetrix) we determined the miRNA expression profile in 40 CMs compared with 7 normal conjunctival samples...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27520988/a-case-report-of-a-patient-with-metastatic-ocular-melanoma-who-experienced-a-response-to-treatment-with-the-braf-inhibitor-vemurafenib
#12
A Maleka, G Åström, P Byström, G J Ullenhag
BACKGROUND: Conjunctival malignant melanoma (CMM) is a rare malignancy and in the advanced setting there is no effective treatment. In contrast, half of cutaneous melanomas have BRAF mutations and treatment with BRAF inhibitors is established for patients with disseminated disease. The most common form of ocular melanoma, uveal melanoma, lacks these mutations, however, their presence has been reported for CMM. CASE PRESENTATION: We used the BRAF inhibitor vemurafenib to treat a 53 year-old female suffering from a BRAF(V600E) mutated metastatic CMM...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27487727/a-conjunctival-melanoma-causing-bloody-tears
#13
Maria E Rodriguez, Christopher K Burris, Courtney Y Kauh, Heather D Potter
No abstract text is available yet for this article.
August 1, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27463451/choroidal-malignant-melanoma-with-no-extraocular-extension-presenting-as-orbital-cellulitis
#14
Serhad Nalcaci, Melis Palamar, Banu Yaman, Taner Akalin, Jale Mentes
This report describes a patient with choroidal malignant melanoma presenting as orbital cellulitis without extraocular tumor extension. It is an interventional case report with histopathologic correlation. A 68-year-old male presented with a 3-day history of painful hyperemia and swelling in the right eye. The examination showed edematous eyelids, mechanical ptosis and chemosis with conjunctival injection. B-scan ultrasonography showed a mass with medium level echogenicity that filled the vitreous cavity. Magnetic resonance imaging showed a solid choroidal mass with hemorrhagic and inflammatory changes with no obvious extraocular extension...
October 2016: Orbit
https://www.readbyqxmd.com/read/27462917/targeting-of-the-mapk-and-akt-pathways-in-conjunctival-melanoma-shows-potential-synergy
#15
Jinfeng Cao, Renier C Heijkants, Aart G Jochemsen, Mehmet Dogrusöz, Mark J de Lange, Pieter A van der Velden, Sjoerd H van der Burg, Martine J Jager, Robert M Verdijk
PURPOSE: Conjunctival melanoma (CM) is a rare but lethal form of cancer. Similar to cutaneous melanoma, CM frequently carries activating mutations in BRAF and NRAS. We studied whether CM as well as conjunctival benign and premalignant melanocytic lesions express targets in the mitogen-activated protein kinase (MAPK) and AKT pathways, and whether specific inhibitors can suppress CM growth in vitro. METHODS: 131 conjunctival lesions obtained from 129 patients were collected...
July 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27456560/-nevi-of-conjunctiva-as-a-risk-factor-of-melanoma
#16
R N Balaeva, E M Kasimov
UNLABELLED: Conjunctival nevi are the most common tumors of this location. They are usually unilateral, although bilateral cases may also be met. As to clinical presentation, all nevi are divided into: stationary or progressive nevi, blue nevi, and primary acquired melanosis. Color changes are acceptable, if they occur during pregnancy or puberty. However, if postpubertal, such changes should be considered alarming, as to possible malignization. Histopathologically, nevi are composed of melanocyte clusters in the skin stroma next to the basal layer of the epidermis...
May 2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27450815/extremely-invasive-conjunctival-melanoma
#17
Ido D Fabian, Caroline Thaung, Victoria M L Cohen
No abstract text is available yet for this article.
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27447296/unusual-ocular-presentations-of-ocular-phaeohyphomycosis
#18
A Maudgil, Z Johnson, N Rogers, H S Mudhar
PurposePhaeohyphomycosis are melanin-containing fungi that rarely infect the eye. We describe three cases of ocular infection with some unusual clinical features.MethodsSeries of three case reports describing three different presentations of phaeohyphomycosis of the eye, their histopathology, and management.ResultsCase 1 mimicked an inflamed conjunctival naevus and was excised on this basis, revealing a conjunctival retention cyst containing pigmented fungal hyphae. Case 2 showed a wooden foreign body incidentally associated with pigmented fungal hyphae, which required treatment with topical antifungal therapy...
July 22, 2016: Eye
https://www.readbyqxmd.com/read/27321895/advances-in-the-management-of-conjunctival-melanoma
#19
REVIEW
Gargi K Vora, Hakan Demirci, Brian Marr, Prithvi Mruthyunjaya
Malignant melanoma of the conjunctiva is a rare but serious condition. Over the last several years, there have been important advances in the classification, diagnosis, and treatment of this condition. Recent cytogenetic and immunohistochemical studies are increasing understanding of its tumorigenesis. Diagnosis, although still made via histopathology, has been aided with imaging techniques such as ultrasound biomicroscopy and anterior segment optical coherence tomography. Primary treatment consists of surgical excision...
June 16, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27296488/fluorescence-confocal-microscopy-for-ex%C3%A2-vivo-diagnosis-of-conjunctival-tumors-a-pilot-study
#20
Alfonso Iovieno, Caterina Longo, Mariacarla De Luca, Simonetta Piana, Luigi Fontana, Moira Ragazzi
PURPOSE: To evaluate the potential use of fluorescence confocal microscopy (FCM) for ex vivo diagnosis and excision margin assessment of conjunctival neoplasms. DESIGN: Validity study. METHODS: setting: Single institution. PARTICIPANTS: Consecutive patients with clinically suspicious conjunctival lesions. INTERVENTION: Conjunctival lesions were excised in toto using a standard "no-touch technique" by a single surgeon (A...
August 2016: American Journal of Ophthalmology
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