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conjunctival melanoma

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https://www.readbyqxmd.com/read/28211877/fresh-frozen-amniotic-membrane-for-conjunctival-reconstruction-after-excision-of-neoplastic-and-presumed-neoplastic-conjunctival-lesions
#1
U Agraval, P Rundle, I G Rennie, S Salvi
PurposeSuspicious neoplastic conjunctival lesions often require wide excision with tumour-free margins, leaving significant conjunctival defects requiring reconstruction. In this study we report the results of using fresh frozen amniotic membrane grafts (AMG) after wide excision of potentially malignant lesions.MethodsRetrospective review of 53 patients; between January 2011 and April 2014. Conjunctival lesions were excised with a non-touch technique (2 mm margin) and sent for histopathological analysis. The surgical margins were treated with cryotherapy and a fresh frozen AMG was used to cover the defect...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28161440/immunohistochemical-profiling-including-beta-catenin-in-conjunctival-melanocytic-lesions
#2
Harsha S Reddy, C Dirk Keene, Shu H Chang, Arash Jian-Amadi, Patrick J Cimino
Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 primary acquired melanosis (PAM) lesions, and 11 conjunctival melanomas. Immunostains included the melanocytic markers HMB-45 and Melan-A, as well as the proliferative marker Ki-67. Loss of beta-catenin expression has been associated with more aggressive clinical disease in cutaneous melanoma, but its status in conjunctival melanocytic lesions is not known, therefore we incorporated beta-catenin immunohistochemical staining in our study...
February 1, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28125759/clinical-features-differentiating-benign-from-malignant-conjunctival-tumors-in-children
#3
Carol L Shields, Kareem Sioufi, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Emil Anthony T Say, Jerry A Shields
Importance: Conjunctival tumors in children are usually benign and rarely malignant. Objective: To evaluate clinical features of conjunctival tumors in children by comparing benign tumors with their malignant counterparts. Design, Setting, and Participants: This retrospective case series reviewed 806 cases of conjunctival tumor in children (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and July 1, 2015...
January 26, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28121720/the-use-of-integra%C3%A2-dermal-regeneration-template-for-the-orbital-exenteration-socket-a-novel-technique
#4
Cem Ozgonul, Ana Beatriz Diniz Grisolia, Hakan Demirci
PURPOSE: Integra® dermal regeneration template is a bilayer membrane system that acts as a scaffold for regenerating dermal skin cells. It is used for wound reconstruction following burns, extensive injuries, and a large tumor excision in multiple parts of the body. The dermal layer is made of porous matrix of bovine tendon collagen and glycosaminoglycan. The epidermal layer is made of polysiloxane layer. In this study, the authors evaluated the use of Integra® dermal regeneration template for the immediate reconstruction of the orbital exenteration socket...
January 23, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28115829/ocular-melanoma-when-you-have-seen-one-you-have-not-seen-them-all-a-clinical-outcome-study-from-the-surveillance-epidemiology-and-end-results-seer-database-1973-2012
#5
Krishnaraj Mahendraraj, Sneha Shrestha, Christine Sm Lau, Ronald S Chamberlain
BACKGROUND: Ocular melanoma (OM) comprises <5% of all melanomas. Uveal melanoma (UM) is the most common subtype of OM, while conjunctival melanoma (CM) is rare and differs significantly from UM. The purpose of this study is to evaluate a large cohort of OM patients to differentiate demographic, pathologic, and clinical factors between these two neoplasms, which may affect treatment and outcomes. METHODS: The Surveillance, Epidemiology, and End Results database (1973-2012) was used to extract demographic and clinical data on 8,165 OM patients (92...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28069617/ocular-oncology-advances-in-retinoblastoma-uveal-melanoma-and-conjunctival-melanoma
#6
REVIEW
Marina Vasalaki, Ido D Fabian, M Ashwin Reddy, Victoria M L Cohen, Mandeep S Sagoo
BACKGROUND: Retinoblastoma, uveal and conjunctival melanomas are important malignancies within the remit of ocular oncology. Outlined are the diagnostic features and management principles, as well as advancements in the field and current challenges. SOURCES OF DATA: Original papers, reviews and guidelines. AREAS OF AGREEMENT: Most eyes with retinoblastoma (International Intraocular Retinoblastoma Classification (IIRC) Group A-D) are salvaged, whereas advanced cases (Group E) remain a challenge...
January 8, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28005633/twenty-five-gauge-cannula-assisted-fine-needle-aspiration-biopsy-of-choroidal-melanoma-cytopathological-analysis
#7
Arun D Singh, Hassan A Aziz, David Pelayes, Charles V Biscotti
PURPOSE: To report cytopathological observations on the cells retrieved from the 25-G cannula used during prognostic transvitreal fine-needle aspiration biopsy of choroidal melanoma. METHODS: Transvitreal fine-needle aspiration biopsy of choroidal melanoma was performed through a 25-G valved cannula. Twenty samples from 20 consecutive patients were obtained. Most tumors were treated with plaque radiation therapy (16/20, 80%) following standard clinical guidelines...
December 21, 2016: Retina
https://www.readbyqxmd.com/read/27939646/-contribution-of-reflectance-confocal-microscopy-in-the-diagnosis-of-conjunctival-melanoma
#8
C Ronin, D Grivet, M Kaspi, J-M Dumollard, C Douchet, G Thuret, P Gain, B Labeille, E Cinotti, J-L Perrot
No abstract text is available yet for this article.
December 7, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27898616/the-role-for-sentinel-lymph-node-biopsy-in-the-management-of-conjunctival-melanoma
#9
Jeanie Ling, Robert Tauscher, Viraj Mehta, Matthew Zhang, Anthony Daniels, Sahar Kohanim
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/27893585/conjunctival-melanoma-responsive-to-combined-systemic-braf-mek-inhibitors
#10
Lora R Dagi Glass, Donald P Lawrence, Frederick A Jakobiec, Suzanne K Freitag
This report demonstrates a unique case of conjunctival melanoma harboring a BRAF V600E mutation responsive to systemic therapy with BRAF and MEK inhibitors. While systemic therapy would not be appropriate in patients with local disease alone, it may act therapeutically in cases of higher stage ocular surface and eyelid melanoma.
November 23, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27869370/conjunctival-malignant-melanoma-in-denmark-epidemiology-treatment-and-prognosis-with-special-emphasis-on-tumorigenesis-and-genetic-profile
#11
Ann-Cathrine Larsen
No abstract text is available yet for this article.
December 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27843900/separate-primary-melanomas-of-the-bulbar-conjunctiva-and-eyelid-skin-clinical-implications-of-multiple-primary-melanomas
#12
Frances A Jacinto, George H Fisher, Edgar M Espana, Ilya M Leyngold, Curtis E Margo
PURPOSE: We report a patient with previous in situ melanoma of the forehead skin who was referred for treatment of a bulbar conjunctival melanoma and a separate superficially invasive melanoma of the eyelid skin, and we offer a review of the biological and clinical implications of patients who have multiple primary melanomas. METHODS: This article offers a clinicopathological correlation with a review of the relevant literature. RESULTS: An 80-year-old white man was referred for evaluation of a suspicious conjunctival tumor and a lower-eyelid lesion...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27832282/conjunctival-melanoma-in-a-black-patient
#13
Stéphanie Lemaitre, Paul Fréneaux, Nathalie Cassoux
No abstract text is available yet for this article.
November 10, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27775232/sentinel-lymph-node-biopsy-for-ocular-adnexal-melanoma
#14
Margaret L Pfeiffer, Omar K Ozgur, Jeffrey N Myers, Andrew Peng, Jing Ning, Mark E Zafereo, Sudip Thakar, Bradley Thuro, Victor G Prieto, Merrick I Ross, Bita Esmaeli
BACKGROUND: We sought to update our prior report of findings on sentinel lymph node biopsy (SLNB) and predictors of a positive SLN in patients with conjunctival or eyelid melanoma. METHODS: We reviewed the records of all patients with ocular adnexal melanoma who underwent SLNB at one institution during 2000-2015. We determined rates of positive and false-negative findings on SLNB, primary tumour features correlated with positive findings and rate of nodal recurrence (false-negative event) after negative findings...
October 24, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27760645/-the-clinical-and-histopathological-analysis-of-2-053-cases-of-conjunctival-neoplasms
#15
J J Huang, B Li, Q F Liang, X L Xu, F Gao, Z B Zhang
Objective: We aimed to identify and describe the clinical and histopathologic characteristics of conjunctival neoplasms. Methods: Retrospective case series study. We collected and analyzed the clinical and histopathologic data of the conjunctival neoplastic specimens including the age, gender, and histopathologic diagnosis of all patients obtained from Beijing Tongren Eye Center between October 2003 and October 2015. All the pathology diagnosis results were divided into two categories which were benign and malignant tumors, according to Shields histopathological classification methods and the pathology diagnosis results in our department...
October 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27725148/conjunctival-tumors-in-5002-cases-comparative-analysis-of-benign-versus-malignant-counterparts-the-2016-james-d-allen-lecture
#16
Carol L Shields, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Alexzandra M Douglass, Kareem Sioufi, Emil A T Say, Jerry A Shields
PURPOSE: To evaluate frequency of conjunctival tumors in all ages and compare benign vs malignant counterparts. DESIGN: Retrospective series. METHODS: setting: Tertiary referral center. STUDY POPULATION: Total of 5002 patients. OBSERVATION: Clinical features. MAIN OUTCOME MEASURE: Differentiation of benign from malignant counterparts. RESULTS: The tumor was benign (52%), premalignant (18%), or malignant (30%)...
January 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27662198/immune-checkpoint-inhibitors-for-treatment-of-metastatic-melanoma-of-the-orbit-and-ocular-adnexa
#17
Joshua Ford, Bradley A Thuro, Sudip Thakar, Wen-Jen Hwu, Karina Richani, Bita Esmaeli
Programmed cell death 1 (PD-1) inhibitors are members of a new class of drugs known as immune checkpoint inhibitors and have proven efficacy in the treatment of metastatic melanoma. Herein, the authors report the use of nivolumab and pembrolizumab, 2 recently Food and Drug Administration-approved PD-1 inhibitors, in 3 patients: 1 with metastatic conjunctival melanoma and 2 with metastatic cutaneous melanoma and orbital involvement. The patients' metastatic disease responded well to drug treatment. As of this writing, 2 patients have completed therapy and remain disease free at least 1 year after treatment completion; the other patient is still receiving treatment, and his orbital disease is responding...
September 21, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27606149/melanocytic-nevus-of-the-tarsal-conjunctiva
#18
Bülent Yazıcı, Ayşe Dolar Bilge, Ayşe Yağcı, Faisal Naqadan, Filiz Altıntepe
BACKGROUND: Melanocytic nevus is a rare occurrence in the tarsal conjunctiva and only 7 well-described cases have been reported previously in the English literature. CASE REPORT: The medical records of 4 patients with tarsal conjunctival melanocytic nevus were reviewed, together with the relevant literature. All patients (3 women and 1 man; age range: 17 - 40 years) had been referred with a suspicion of melanoma. There was one tarsal nevus in the lower eyelid in 3 patients and 2 nevi in the upper eyelid in 1 patient...
July 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27548891/microrna-expression-profile-in-conjunctival-melanoma
#19
Ann-Cathrine Larsen, Lauge H Mikkelsen, Rehannah Borup, Katalin Kiss, Peter B Toft, Christian von Buchwald, Sarah E Coupland, Jan U Prause, Steffen Heegaard
PURPOSE: Conjunctival melanoma (CM) is a rare disease associated with considerable mortality. As opposed to cutaneous melanoma, the epigenetic mechanisms involved in the development of CM and other mucosal melanomas (MMs) are unclear. The purpose of this study was to identify tumor-specific and prognostic microRNA (miRNA) in CM and to compare the miRNA profile with that of MM. METHODS: Using microarray analysis (Affymetrix) we determined the miRNA expression profile in 40 CMs compared with 7 normal conjunctival samples...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27520988/a-case-report-of-a-patient-with-metastatic-ocular-melanoma-who-experienced-a-response-to-treatment-with-the-braf-inhibitor-vemurafenib
#20
A Maleka, G Åström, P Byström, G J Ullenhag
BACKGROUND: Conjunctival malignant melanoma (CMM) is a rare malignancy and in the advanced setting there is no effective treatment. In contrast, half of cutaneous melanomas have BRAF mutations and treatment with BRAF inhibitors is established for patients with disseminated disease. The most common form of ocular melanoma, uveal melanoma, lacks these mutations, however, their presence has been reported for CMM. CASE PRESENTATION: We used the BRAF inhibitor vemurafenib to treat a 53 year-old female suffering from a BRAF(V600E) mutated metastatic CMM...
2016: BMC Cancer
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