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conjunctival melanoma

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https://www.readbyqxmd.com/read/28938534/targeting-of-the-mapk-and-akt-pathways-in-conjunctival-melanoma-shows-potential-synergy
#1
Jinfeng Cao, Renier C Heijkants, Aart G Jochemsen, Mehmet Dogrusöz, Mark J de Lange, Pieter A van der Velden, Sjoerd H van der Burg, Martine J Jager, Robert M Verdijk
PURPOSE: Conjunctival melanoma (CM) is a rare but lethal form of cancer. Similar to cutaneous melanoma, CM frequently carries activating mutations in BRAF and NRAS. We studied whether CM as well as conjunctival benign and premalignant melanocytic lesions express targets in the mitogen-activated protein kinase (MAPK) and AKT pathways, and whether specific inhibitors can suppress CM growth in vitro. METHODS: 131 conjunctival lesions obtained from 129 patients were collected...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937145/immunoreduction-of-ocular-surface-tumours-with-intralesional-interferon-alpha-2a
#2
S E Kim, S M Salvi
PurposeTo share our initial experience in the use of intralesional interferon alpha-2a at primary presentation in ocular surface tumours as a method of immunoreduction prior to definitive surgical management.MethodsCase series of patients referred to Sheffield Ocular Oncology Service with rapidly growing ocular surface tumours, treated with intralesional interferon alpha-2a at first presentation prior to definitive surgical management.ResultsAll three patients, two with conjunctival melanoma and one with ocular surface squamous neoplasia (OSSN) demonstrated immunoreduction of tumour without any adverse side effects...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28912992/giant-conjunctival-nevus-in-a-12-year-old-child
#3
Edit Tóth-Molnár, Eszter Vizvári, Ákos Skribek, András Vörös
We describe a case of a giant conjunctival nevus presented in a 12-year-old girl with suspicious clinicomorphological appearance. The lesion was noticed by the parents at the age of 3 years as a "fleshy spot" on the bulbar conjunctiva. The lesion remained unchanged until approx. 6 months before recent admission. On slit-lamp examination, a large conjunctival lesion with variegate pigmentation and indistinct margins was detected on the superonasal part of the bulbar conjunctiva of the left eye. Intralesional cysts and vessels were detected with AS-OCT examination...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28903377/pd-l1-pd-1-expression-and-tumor-infiltrating-lymphocytes-in-conjunctival-melanoma
#4
Jinfeng Cao, Niels J Brouwer, Kate E Richards, Marina Marinkovic, Sjoerd van Duinen, Daan Hurkmans, Els M E Verdegaal, Ekaterina S Jordanova, Martine J Jager
Conjunctival melanoma (CM) is an infrequent but potentially lethal malignancy, with limited therapeutic options for metastases. Recent inhibitors of the interaction of programmed cell death protein 1 (PD-1) and its ligand PD-L1 are associated with good clinical responses in many malignancies. To investigate the therapeutic potential of targeting the PD-1/PD-L1 axis in CM, we analyzed the expression of PD-1 and PD-L1 and the density of various types of tumor-infiltrating lymphocytes (TILs) in primary CM (n = 27), using immunofluorescence staining...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28898915/-current-therapies-in-superficial-malignant-tumors
#5
Simone Luisa Scholz, Anja Eckstein, Dirk Dekowski, Joachim Esser, Henrike Westekemper, Klaus P Steuhl
This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences.Basal cell carcinoma is the most common tumor of the periocular skin, divided into three subtypes (nodular, superficial and morphea)...
September 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28868285/systemic-braf-mek-inhibitors-as-a-potential-treatment-option-in-metastatic-conjunctival-melanoma
#6
REVIEW
Joel M Mor, Ludwig M Heindl
AIM: In this review, we outline similarities between conjunctival and skin melanoma as well as the effectiveness of combined BRAF/MEK inhibition in melanoma, and discuss the applicability of these agents in conjunctival melanoma. METHODS: The study provides a PubMed literature review. RESULTS: Conjunctival melanoma and skin melanoma are genetically and phenotypically related. Both tumors typically harbor BRAF mutations in more than 50% of cases...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868281/multiple-pigmented-conjunctival-lesions-following-intravitreal-injections-in-a-patient-with-uveal-melanoma
#7
Niels J Brouwer, Gregorius P M Luyten, Sjoerd G van Duinen, Martine J Jager, Marina Marinkovic
PURPOSE: This paper reports a case of pigmented conjunctival lesions after intravitreal injections in a patient who received brachytherapy for uveal melanoma. METHODS: Clinical and histopathological examination of the pigmented conjunctival lesions was performed. RESULTS: A 57-year-old male who was treated with brachytherapy for uveal melanoma developed radiation retinopathy. Following intravitreal anti-vascular endothelial growth factor (VEGF) injections, 2 pigmented conjunctival spots appeared at the injection sites...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28868278/conjunctival-melanoma-during-pregnancy
#8
Rana'a T Al-Jamal, Hardeep Singh Mudhar, Zanna Currie, Ian G Rennie, Sachin M Salvi
PURPOSE: To describe the clinical and histopathological features of a conjunctival melanoma (CM) during early pregnancy. PROCEDURES: A 37-year-old, 20-week pregnant primigravida was referred to the Sheffield Ocular Oncology Service with a rapidly growing lesion arising from the right superior conjunctival fornix, noted from the first trimester of pregnancy. This was associated with pain and bloody discharge. Incisional biopsy confirmed the clinical suspicion of invasive CM...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28860029/pediatric-conjunctival-melanoma-arising-from-a-compound-nevus
#9
Katy C Liu, Prithvi Mruthyunjaya, Alan D Proia, Gargi K Vora
No abstract text is available yet for this article.
August 28, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28834816/donor-derived-conjunctival-limbal-melanoma-after-a-keratolimbal-allograft
#10
Lorena Sepsakos, Albert Y Cheung, Jeffrey A Nerad, Gautham Mogilishetty, Edward J Holland
PURPOSE: To report a single case of donor-derived conjunctival-limbal melanoma that occurred after a keratolimbal allograft (KLAL). METHODS: Case report and literature review. RESULTS: A 56-year-old white woman with a history of bilateral limbal stem cell deficiency developed a donor-related melanoma after a KLAL. Three months after undergoing an uncomplicated KLAL, the patient presented with hemorrhagic nodules within her conjunctiva and transplanted tissue...
August 22, 2017: Cornea
https://www.readbyqxmd.com/read/28801376/cellular-blue-nevus-of-perilimbal-conjunctiva-a-case-report-and-review-of-literature
#11
Tiangeng He, Chunjie Mao, Dongbo Xu, Hua Yan
Cellular blue nevus is an uncommon neoplasm in the conjunctiva. Here we present an unusual case of a cellular blue nevus that clinically resembled conjunctival melanoma. A 29-year-old Chinese male was found to have a giant pigmented lesion of the conjunctiva around the limbal area of right eye from birth. Excisional biopsy with no-touch technique, lamellar corneal transplantation, amniotic membrane transplantation and adjuvant cryotherapy were performed. Histopathology revealed a nodular, well-defined tumor, which was composed of heavily pigmented dendritic cells and less pigmented spindle cells...
August 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28752368/long-term-follow-up-of-conjunctival-melanoma-treated-with-topical-interferon-alpha-2b-eye-drops-as-adjunctive-therapy-following-surgical-resection
#12
Iku Kikuchi, Satoru Kase, Kan Ishijima, Susumu Ishida
PURPOSE: The purpose of this study was to report the clinical outcomes of patients with conjunctival melanoma treated with interferon (IFN) α-2b eye drops following local tumor resection. METHODS: Five eyes of five patients were enrolled in this study. All patients underwent the local resection of tumors, and topical IFNα-2b eye drops were subsequently administered 4 times/day until the complete disappearance of the pigmented lesions determined by slit-lamp examination...
July 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28715523/pembrolizumab-for-recurrent-conjunctival-melanoma
#13
Ashwini Kini, Roxana Fu, Christopher Compton, Donald M Miller, Aparna Ramasubramanian
No abstract text is available yet for this article.
August 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28700778/frequent-gnaq-gna11-and-eif1ax-mutations-in-iris-melanoma
#14
Simone L Scholz, Inga Möller, Henning Reis, Daniela Süßkind, Johannes A P van de Nes, Sonia Leonardelli, Bastian Schilling, Elisabeth Livingstone, Tobias Schimming, Annette Paschen, Antje Sucker, Rajmohan Murali, Klaus-Peter Steuhl, Dirk Schadendorf, Henrike Westekemper, Klaus G Griewank
Purpose: The most common malignant intraocular tumors with a high mortality in adults are uveal melanomas. Uveal melanomas arise most frequently in the choroid or ciliary body (97%) and rarely in the iris (3%). Whereas conjunctival and posterior uveal (ciliary body and choroidal) melanomas have been studied in more detail genetically, little data exist regarding iris melanomas. Methods: In our study, we genetically analyzed 19 iris melanomas, 8 ciliary body melanomas, 3 ring melanomas, and 4 iris nevi...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28700252/modified-allogenic-simple-limbal-epithelial-transplantation-followed-by-keratoplasty-as-treatment-for-total-limbal-stem-cell-deficiency
#15
Alfonso Vasquez-Perez, Mayank A Nanavaty
PURPOSE: To describe a modified allogenic simple limbal epithelial transplant (SLET) technique with large donor tissue explants followed by keratoplasty. METHODS: A 69-year-old with conjunctival melanoma on her left eye developed total limbal stem cell deficiency (LSCD) after multiple cycles of topical mitomycin. She also had herpes stromal keratitis while on treatment with mitomycin. She underwent modified allogenic SLET with large donor limbal tissue explants glued on the cornea directly and the amniotic membrane placed over the limbal explants...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28690979/presentation-treatment-and-prognosis-of-secondary-melanoma-within-the-orbit
#16
Anna M Rose, Sophie Cowen, Channa N Jayasena, David H Verity, Geoffrey E Rose
BACKGROUND: Ocular melanoma is a rare but often deadly malignancy that arises in the uvea, conjunctiva, or orbit. Uveal melanoma is the most common type, with conjunctival melanoma being the second most frequently observed. Melanoma accounts for 5-10% of metastatic or secondary orbital malignancies, but only a minute proportion of primary orbital neoplasia. The aim of this study was to characterize the clinical presentation, treatment, and prognosis in patients presenting with melanoma metastatic to, or secondary within, the orbit...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28673748/late-solitary-extraocular-recurrence-from-previously-resected-iris-melanoma
#17
Ido Didi Fabian, Caroline Thaung, Lamis AlHarby, Karen Sisley, Hardeep S Mudhar, Rachel E Doherty, Andrew W Stacey, Amit K Arora, Victoria M L Cohen, Mandeep S Sagoo
PURPOSE: To report on cases of late extraocular relapse of previously resected iris melanoma, without concurrent intraocular recurrence. DESIGN: Retrospective case series. METHODS: A retrospective chart review of 4 patients diagnosed with late subconjunctival relapse of previously resected iris melanoma. RESULTS: Three female patients and 1 male patient underwent iris tumor resection and presented to our service with suspicious conjunctival lesions at a median of 22 years later (mean: 21 years)...
September 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28654937/handheld-in-vivo-reflectance-confocal-microscopy-for-the-diagnosis-of-eyelid-margin-and-conjunctival-tumors
#18
Elisa Cinotti, Aurélie Singer, Bruno Labeille, Damien Grivet, Pietro Rubegni, Catherine Douchet, Frédéric Cambazard, Gilles Thuret, Philippe Gain, Jean Luc Perrot
Importance: The clinical diagnosis of conjunctival and eyelid margin tumors is challenging, and new noninvasive imaging techniques could be valuable in this field. Objective: To assess the diagnostic accuracy of handheld in vivo reflectance confocal microscopy (IVCM) for the diagnosis of eyelid margin and conjunctival tumors. Design: A prospective observational study was conducted at University Hospital of Saint-Etienne from January 2, 2011, to December 31, 2016 (inclusion of patients until December 31, 2015, and follow-up until December 31, 2016)...
August 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28626853/conjunctival-melanoma-in-southwestern-nigeria-a-case-series-and-review-of-literature
#19
Oluyemi Fasina, Olayiwola A Oluwasola
PURPOSE: Conjunctival melanoma is a rare tumor worldwide and is extremely rare among black population. This study aims to report the demographics, clinical presentation, treatment, and outcome of patients seen in an indigenous black population in Southwestern Nigeria. METHODS: All patients histologically diagnosed with conjunctival melanoma and managed in the facility were reviewed. Their demographics, clinical presentation, treatment received, outcome of treatment, and histopathological features were analyzed...
June 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28622066/vascular-associated-muc4-vwf-co-localization-in-human-conjunctival-malignant-melanoma-specimens-tumor-metastasis-by-migration
#20
Vinodh Kakkassery, Sibylle Winterhalter, Ann-Christin Nick, Stephanie C Joachim, Antonia M Joussen, Norbert Kociok
PURPOSE: To investigate whether vascular differentiation marker von Willebrand factor (vWf) and proliferation marker KI67 expression correlate with MUC4 localization around stromal tumor vascularization in human conjunctival malignant melanoma (CMM). MATERIALS AND METHODS: For the purposes of this study, we analyzed samples from human CMMs (n = 4), conjunctival compound nevi (n = 7), and samples from healthy conjunctiva (n = 7) for MUC1, 4, and 16 by immunohistochemistry...
June 16, 2017: Current Eye Research
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