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conjunctival melanoma

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https://www.readbyqxmd.com/read/29780923/possible-dissemination-of-conjunctival-melanoma-along-tear-flow-path
#1
Toshinobu Kubota, Tomonori Kawasaki
No abstract text is available yet for this article.
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29778279/outcomes-after-surgical-resection-of-lower-eyelid-tumors-and-reconstruction-using-a-nasal-chondromucosal-graft-and-an-upper-eyelid-myocutaneous-flap
#2
S Lemaître, C Lévy-Gabriel, L Desjardins, M González-Candial, S Gardrat, R Dendale, N Cassoux, B Couturaud
INTRODUCTION: Surgical excision of large malignant lower eyelid tumors may cause important full-thickness eyelid defects. The reconstruction of such defects must restore the physiologic function of the eyelid and also re-establish an acceptable aesthetic result. MATERIALS AND METHODS: We report the outcomes of full-thickness excision of tumors extending over half of the horizontal lid length, followed by reconstruction using a nasal chondromucosal graft (coming from the ipsilateral ala of the nose) and an upper eyelid myocutaneous flap...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29777046/lack-of-tumour-pigmentation-in-conjunctival-melanoma-is-associated-with-light-iris-colour-and-worse-prognosis
#3
Niels J Brouwer, Marina Marinkovic, Gregorius P M Luyten, Carol L Shields, Martine J Jager
AIM: To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma. METHODS: Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses...
May 18, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29732557/overexpression-of-ezh2-in-conjunctival-melanoma-offers-a-new-therapeutic-target
#4
Jinfeng Cao, Kelly C S Pontes, Renier C Heijkants, Niels J Brouwer, Arwin Groenewoud, Ekaterina S Jordanova, Marina Marinkovic, Sjoerd van Duinen, Amina F A S Teunisse, Robert M Verdijk, Ewa Snaar-Jagalska, Aart G Jochemsen, Martine J Jager
Malignant melanoma of the conjunctiva (CM) is an uncommon but potentially deadly disorder. Many malignancies show an increased activity of the epigenetic modifier Enhancer of zeste homolog 2 (EZH2). We studied whether EZH2 is expressed in CM, and whether it may be a target for therapy in this malignancy. Immunohistochemical analysis showed that EZH2 protein expression was absent in normal conjunctival melanocytes and primary acquired melanosis, while EZH2 was highly expressed in 13 (50%) of 26 primary CM and seven (88%) of eight lymph node metastases...
May 7, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29653142/characterization-of-a-conjunctival-melanoma-cell-line-cm-as16-newly-established-from-a-metastatic-han-chinese-patient
#5
Yongyun Li, Qingfeng Shang, Peng Li, Jinfeng Cao, Liqi Zhu, Martine J Jager, Xianqun Fan, Shengfang Ge, Renbing Jia
Conjunctival melanoma (CM) is associated with metastases formation, can be fatal, and occurs in all different races. While cell lines are essential for experimental research, all available CM cell lines are derived from Caucasian patients. Furthermore, they are not derived from metastases. We aimed to establish a new CM cell line from a parotid metastasis in a Han Chinese patient and to depict its characteristics. The novel cell line, CM-AS16, was obtained from a surgical parotid sample and determined as a unique one with short tandem repeat (STR) analysis...
April 10, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29576892/amniotic-membrane-transplantation-in-surgical-treatment-of-conjunctival-melanoma-long-term-results
#6
Melis Palamar, Banu Yaman, Taner Akalın, Ayse Yağcı
Objectives: To investigate the long-term efficacy and results of surgical management of conjunctival melanoma reconstructed with amniotic membrane transplantation. Materials and Methods: Conjunctival melanoma in 10 patients (5 female, 5 male) was totally excised with adjunctive cryotherapy to the surgical margins, corneal epitheliectomy with absolute alcohol in cases of corneal involvement, lamellar sclerectomy in cases with episcleral involvement, and ocular surface grafting with cryopreserved amniotic membrane...
February 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29559732/nf1-mutations-in-conjunctival-melanoma
#7
S L Scholz, I Cosgarea, D Süßkind, R Murali, I Möller, H Reis, S Leonardelli, B Schilling, T Schimming, E Hadaschik, C Franklin, A Paschen, A Sucker, K P Steuhl, D Schadendorf, H Westekemper, K G Griewank
BACKGROUND: Conjunctival melanoma is a potentially deadly eye tumour. Despite effective local therapies, tumour recurrence and metastasis remain frequent. The genetics of conjunctival melanomas remain incompletely understood. METHODS: A large cohort of 63 conjunctival melanomas was screened for gene mutations known to be important in other melanoma subtypes by targeted next-generation sequencing. Mutation status was correlated with patient prognosis. RESULTS: Frequent mutations in genes activating the MAP kinase pathway were identified...
March 21, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29551421/blue-nevi-of-the-ocular-surface-clinical-characteristics-pathologic-features-and-clinical-course
#8
Ibrahim Sayed-Ahmed, Juan Carlos Murillo, Pedro Monsalve, Jan Paul Ulloa, Maria P Fernandez, James Wong, George Elgart, Anat Galor, Sander R Dubovy, Carol L Karp
PURPOSE: Blue nevus is a melanocytic tumor that is commonly found in the skin. Extracutaneous presentations, including the ocular surface, are rare. As such, the purpose of this study was to characterize the clinical features and clinical course of congenital melanocytic tumor (blue nevus) of the conjunctiva. DESIGN: Retrospective, noncomparative case series. PARTICIPANTS: Twenty-one patients with 23 blue nevi of the ocular surface that were excised surgically between 2000 and 2016...
March 15, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29511061/population-based-incidence-of-conjunctival-tumours-in-olmsted-county-minnesota
#9
Lauren A Dalvin, Diva R Salomão, Sanjay V Patel
AIM: To determine population-based incidence of conjunctival tumours in Olmsted County, Minnesota. METHODS: The Rochester Epidemiology Project medical record linkage system was used to identify patients with conjunctival tumours in Olmsted County (1 January 1980 to 31 December 2015). Records were reviewed for demographics, types of tumours, histopathology, treatment and clinical course. Incidence rate of all tumours was calculated per 1 000 000 person-years. Poisson regression analysis was used to assess changes in incidence over time...
March 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29475731/-adjuvant-contact-radiotherapy-for-conjunctival-malignancies-preliminary-results-of-a-series-of-14-patients-treated-with-the-papillon-50-machine
#10
R Coquard, A M N'Guyen, T Mathis, F Josserand-Pietri, M Khodri, G Largeron, N Barbet, J D Grange
PURPOSE: To evaluate the results of an adjuvant contact irradiation using 50kV photons after resection of conjunctival malignancies. MATERIALS AND METHOD: From 2012 to 2014, 14 patients (male: nine; female: five) have been treated by contact irradiation after resection of a malignant tumor of the conjunctiva (melanoma: five patients; malignant fibrous histiocytoma: one patient; carcinoma: eight patients) The treatment was performed using the Papillon 50 machine (Ariane)...
April 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29468295/-conjunctival-melanoma-standard-operating-procedures-in-diagnosis-treatment-and-follow-up-care
#11
Jan-Peter Glossmann, Nicole Skoetz, Barbara Starbatty, Martina Bischoff, Serge Leyvraz, Henrike Westekemper, Ludwig M Heindl
BACKGROUND: In cases of rare cancer entities, such as malignant melanoma of the conjunctiva, there are often no evidence-based national guidelines available. Standard operating procedures (SOP) are an alternative in these cases. OBJECTIVE: The aim of this project was to develop a consensus SOP for diagnosis, treatment, and follow-up care of conjunctival melanomas between the 14 Centers of Excellence in Germany supported by German Cancer Aid. METHODS: The SOP was prepared according to a defined process including timelines, flow of information, and roles...
February 21, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29450544/hla-class-i-antigen-expression-in-conjunctival-melanoma-is-not-associated-with-pd-l1-pd-1-status
#12
Jinfeng Cao, Niels J Brouwer, Ekaterina S Jordanova, Marina Marinkovic, Sjoerd G van Duinen, Nadine E de Waard, Bruce R Ksander, Arend Mulder, Frans H J Claas, Mirjam H M Heemskerk, Martine J Jager
Purpose: Antitumor T cells need expression of HLA class I molecules but can be inhibited by ligands such as programmed death ligand 1 (PD-L1). We determined expression and regulation of these molecules in human conjunctival melanoma (CM) samples, cell lines, and murine xenografts. Methods: Immunofluorescence staining was performed to examine the expression of HLA-A, HLA-B/C, and β-2-microglobulin (B2M) in 23 primary CM samples. HLA class I expression was compared with clinicopathologic characteristics, the presence of tumor-infiltrating leukocytes, and PD-L1/PD-1 status...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29403597/compound-nevus-simulating-a-conjunctival-melanoma
#13
Parul Chawla Gupta, Jagat Ram, Madhuri Akella, Jitender Jinagal
No abstract text is available yet for this article.
January 2018: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29380786/melanorrhea-noncontiguous-spread-of-palpebral-conjunctival-melanoma-to-the-nasolacrimal-duct
#14
Raksha Rao, Santosh G Honavar, Michelle De Padua, Kaustubh Mulay, Vijayanand P Reddy
A 42-year-old Asian Indian male with a history of conjunctival melanoma in the left eye presented with a recurrent tumor in the upper tarsal conjunctiva. The tumor was completely excised under margin control, followed by two-staged eyelid reconstruction. During the second stage of the eyelid reconstruction, a brown-colored discharge was noted at the punctum, which on cytology was confirmatory of melanoma. Left dacryocystectomy with en bloc nasolacrimal duct (NLD) excision was performed. Histopathology demonstrated infiltration of the NLD by the tumor with no presence of melanoma in the lacrimal sac...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29297092/conjunctival-melanoma-association-of-cyclooxygenase-2-tumor-expression-to-prognosis
#15
Rita Pinto-Proença, Mariana Santos, Cristina Fonseca, Júlia Fernandes, Maria Filomena Gaspar, Rui Proença
PURPOSE: Conjunctival melanoma is a rare but potentially lethal tumor. Its biologic profile is still largely unknown, with recent studies aiming at establishing histopathological and genetic tumor profiles. The aim of this study was to analyze the association between clinicopathological characteristics and tumor expression of cyclooxygenase-2 (COX-2) to prognosis, assessing its usefulness as a possible prognostic marker. METHODS: Case series of 50 patients from 1991 to 2008 with pathologically proven conjunctival melanoma...
January 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29250968/-ocular-surface-squamous-neoplasia
#16
REVIEW
Gábor Tóth, Gábor László Sándor, Andrea Gyenes, Jeannette Tóth, Berthold Seitz, Zoltán Zsolt Nagy, Nóra Szentmáry
To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29250649/inflammatory-juvenile-compound-conjunctival-nevi-a-clinicopathological-study-and-literature-review
#17
Claudia Florida Costea, Mihaela Dana Turliuc, Gabriela Dimitriu, Camelia Margareta Bogdănici, Anca MoŢoc, Mădălina Adriana Chihaia, Cristina Dancă, Andrei Cucu, Alexandru Cărăuleanu, Nicoleta Dumitrescu, Lucia Indrei, Şerban Turliuc
AIM: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. This article is a clinical pathological study of two cases of IJCNC with particular histopathological characteristics, who were admitted at the 2nd Ophthalmology Clinic, "Prof...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29214089/systemic-treatment-of-metastatic-conjunctival-melanoma
#18
Simão Pinto Torres, Teresa André, Emanuel Gouveia, Lívio Costa, Maria José Passos
Conjunctival melanoma (CM) is an exceptionally rare tumor, with a propensity for local and distant recurrence, with the lungs, skin, liver, and brain being the most common sites of metastasis. Recent progress in systemic treatments, with checkpoint inhibitors and targeted therapies blocking BRAF and MEK, has redefined the standard of care of advanced unresectable and metastatic melanoma. Although most trials did not include patients with conjunctival melanoma, its close molecular and genetic relationship to cutaneous melanoma might suggest a similar response to these novel agents...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29204646/a-novel-zebrafish-model-for-studying-metastatic-behavior-of-human-conjunctival-melanoma-cells
#19
Michele C Madigan
No abstract text is available yet for this article.
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29204645/evaluation-of-fli-gfp-casper-zebrafish-embryos-as-a-model-for-human-conjunctival-melanoma
#20
Kelly Cristine de Sousa Pontes, Arwin Groenewoud, Jinfeng Cao, Livia Maria Silva Ataide, Ewa Snaar-Jagalska, Martine J Jager
Purpose: Conjunctival melanoma (CM) is a rare malignant disease that can lead to recurrences and metastases. There is a lack of effective treatments for the metastases, and we set out to develop a new animal model to test potential therapies. Zebrafish are being used as a model for many diseases, and our goal was to test whether this animal could be used to study CM. Methods: Three human CM cell lines (CRMM-1 and CM2005.1, which both harbor a B-RAF mutation, and CRMM-2, which has an N-RAS mutation) were injected into the yolk sac, around the eye, and into the duct of Cuvier of transgenic (fli:GFP) Casper zebrafish embryos...
December 1, 2017: Investigative Ophthalmology & Visual Science
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