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conjunctival melanoma

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https://www.readbyqxmd.com/read/29297092/conjunctival-melanoma-association-of-cyclooxygenase-2-tumor-expression-to-prognosis
#1
Rita Pinto-Proença, Mariana Santos, Cristina Fonseca, Júlia Fernandes, Maria Filomena Gaspar, Rui Proença
PURPOSE: Conjunctival melanoma is a rare but potentially lethal tumor. Its biologic profile is still largely unknown, with recent studies aiming at establishing histopathological and genetic tumor profiles. The aim of this study was to analyze the association between clinicopathological characteristics and tumor expression of cyclooxygenase-2 (COX-2) to prognosis, assessing its usefulness as a possible prognostic marker. METHODS: Case series of 50 patients from 1991 to 2008 with pathologically proven conjunctival melanoma...
January 2, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29250968/-ocular-surface-squamous-neoplasia
#2
Gábor Tóth, Gábor László Sándor, Andrea Gyenes, Jeannette Tóth, Berthold Seitz, Zoltán Zsolt Nagy, Nóra Szentmáry
To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29250649/inflammatory-juvenile-compound-conjunctival-nevi-a-clinicopathological-study-and-literature-review
#3
Claudia Florida Costea, Mihaela Dana Turliuc, Gabriela Dimitriu, Camelia Margareta Bogdănici, Anca MoŢoc, Mădălina Adriana Chihaia, Cristina Dancă, Andrei Cucu, Alexandru Cărăuleanu, Nicoleta Dumitrescu, Lucia Indrei, Şerban Turliuc
AIM: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. This article is a clinical pathological study of two cases of IJCNC with particular histopathological characteristics, who were admitted at the 2nd Ophthalmology Clinic, "Prof...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29214089/systemic-treatment-of-metastatic-conjunctival-melanoma
#4
Simão Pinto Torres, Teresa André, Emanuel Gouveia, Lívio Costa, Maria José Passos
Conjunctival melanoma (CM) is an exceptionally rare tumor, with a propensity for local and distant recurrence, with the lungs, skin, liver, and brain being the most common sites of metastasis. Recent progress in systemic treatments, with checkpoint inhibitors and targeted therapies blocking BRAF and MEK, has redefined the standard of care of advanced unresectable and metastatic melanoma. Although most trials did not include patients with conjunctival melanoma, its close molecular and genetic relationship to cutaneous melanoma might suggest a similar response to these novel agents...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29204646/a-novel-zebrafish-model-for-studying-metastatic-behavior-of-human-conjunctival-melanoma-cells
#5
Michele C Madigan
No abstract text is available yet for this article.
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29204645/evaluation-of-fli-gfp-casper-zebrafish-embryos-as-a-model-for-human-conjunctival-melanoma
#6
Kelly Cristine de Sousa Pontes, Arwin Groenewoud, Jinfeng Cao, Livia Maria Silva Ataide, Ewa Snaar-Jagalska, Martine J Jager
Purpose: Conjunctival melanoma (CM) is a rare malignant disease that can lead to recurrences and metastases. There is a lack of effective treatments for the metastases, and we set out to develop a new animal model to test potential therapies. Zebrafish are being used as a model for many diseases, and our goal was to test whether this animal could be used to study CM. Methods: Three human CM cell lines (CRMM-1 and CM2005.1, which both harbor a B-RAF mutation, and CRMM-2, which has an N-RAS mutation) were injected into the yolk sac, around the eye, and into the duct of Cuvier of transgenic (fli:GFP) Casper zebrafish embryos...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29126970/malignant-melanoma-presenting-as-amelanotic-caruncular-lesion-in-a-child
#7
Alexander R Walters, Katie M Keck, Oliver Simmons, Sarah G Williams, Stephen Cross, Rakesh M Patel
Conjunctival melanoma is a relatively rare malignant neoplasm that can present in childhood in any part of the conjunctiva. The infrequency with which conjunctival melanoma is encountered in childhood caruncular lesions makes it a formidable but important aspect of the differential diagnosis. We report the case of a 10-year-old boy who presented with a left caruncular lesion. On histopathologic analysis, the lesion was determined to be BRAF-negative invasive melanoma arising in association with melanocytic nevus...
November 7, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29122819/treatment-of-conjunctival-melanoma-in-a-dutch-referral-centre
#8
Niels J Brouwer, Marina Marinkovic, Sjoerd G van Duinen, Jaco C Bleeker, Martine J Jager, Gregorius P M Luyten
AIMS: To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management. METHODS: A retrospective review was performed of clinical and histological data of 70 patients treated for a primary conjunctival melanoma between 2001 and 2014 at the Leiden University Medical Center, Leiden, the Netherlands. Detailed follow-up data were available for all patients. RESULTS: The mean follow-up time was 70...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121185/molecular-characteristics-of-conjunctival-melanoma-using-whole-exome-sequencing
#9
Swarup S Swaminathan, Matthew G Field, David Sant, Gaofeng Wang, Anat Galor, Sander R Dubovy, J William Harbour, Carol L Karp
Importance: Conjunctival melanoma (CM) is a highly aggressive ocular cancer for which treatment options are limited; the molecular pathogenesis is poorly understood. Objective: To identify the molecular characteristics of CM using next-generation whole-exome sequencing (WES). Design, Setting, and Participants: Whole-exome sequencing was performed on tumor DNA extracted from the archived specimens of 5 patients with CM who had been treated with surgical excision between 2006 and 2011...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29111820/identification-of-feeder-vessels-in-ocular-surface-neoplasia-using-indocyanine-green-angiography
#10
Matthias Brunner, Bernhard Steger, Vito Romano, Martin Hodson, Yalin Zheng, Heinrich Heimann, Stephen B Kaye
PURPOSE: To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS: Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of the bulbar conjunctiva were included. Patients underwent anterior segment optical coherence tomography, ICGA, and color photography for the evaluation of the thickness, location, number, and diameter of afferent and efferent vessels of the lesions...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29071272/conjunctival-blue-naevus-in-an-anophthalmic-socket
#11
Hibba Quhill, Paul A Rundle, Hardeep Singh Mudhar
PURPOSE OF THE STUDY: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. PROCEDURES: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29059312/conjunctival-melanoma-in-chinese-patients-local-recurrence-metastasis-mortality-and-comparisons-with-caucasian-patients
#12
COMPARATIVE STUDY
Chuandi Zhou, Yuxin Wang, Renbing Jia, Xianqun Fan
Purpose: To evaluate the prognosis in Chinese patients with conjunctival melanoma and determine its predictors. Further, to explore the racial differences in clinical characteristics and outcomes between Chinese and Caucasian patients. Methods: This cohort study included 57 eyes of 57 consecutive patients with pathologically verified conjunctival melanoma between 1996 and 2016. Medical records were reviewed for factors associated with the local recurrence, metastasis, and tumor-related mortality...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29055731/-malignant-conjunctival-melanoma-arising-from-conjunctival-melanosis-of-reese
#13
S Harchali, M Zarrouki, M Elyadari, S Azenoud, S Elmerrouni, E Abdellah, A Berraho
No abstract text is available yet for this article.
November 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29039986/orbital-exenteration-institutional-review-of-evolving-trends-in-indications-and-rehabilitation-techniques
#14
Hayyam Kiratli, İrem Koç
PURPOSE: To determine the changes in indications for orbital exenteration over 20 years and to assess its impact on patient survival. Evolving techniques of rehabilitation of the orbit in our institution were also evaluated. METHODS: This was a retrospective review of hospital records of patients who underwent orbital exenteration from 1995 to 2015 in a tertiary care center. Data extracted included primary location of the tumor, preoperative treatments, interval between initial diagnosis and exenteration, status of surgical margins, presence of metastatic disease, and postoperative survival...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29038913/-ocular-melanomas-an-update
#15
REVIEW
H Kalirai, P L Müller, D Jaehne, S E Coupland
Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression...
November 2017: Der Pathologe
https://www.readbyqxmd.com/read/28954115/synchronous-conjunctival-melanoma-and-lentigo-maligna-melanoma
#16
Beatrice Mussio Fornazier Volpini, Marcus Maia, Jorge Agi, José Vital, Rute Facchini Lellis
Lentigo maligna has an extensive and neoplastic character. It typically progresses slowly and may eventually develop into an invasive melanoma, which is called lentigo maligna melanoma. Ocular melanoma is the second most common type of melanoma. The uvea is the most common site of origin of ocular melanomas, while conjunctival melanoma accounts for about 1-5% of cases. In this article, we describe a rare case of synchronic conjunctival melanoma and lentigo maligna on the face.
July 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28938534/targeting-of-the-mapk-and-akt-pathways-in-conjunctival-melanoma-shows-potential-synergy
#17
Jinfeng Cao, Renier C Heijkants, Aart G Jochemsen, Mehmet Dogrusöz, Mark J de Lange, Pieter A van der Velden, Sjoerd H van der Burg, Martine J Jager, Robert M Verdijk
PURPOSE: Conjunctival melanoma (CM) is a rare but lethal form of cancer. Similar to cutaneous melanoma, CM frequently carries activating mutations in BRAF and NRAS. We studied whether CM as well as conjunctival benign and premalignant melanocytic lesions express targets in the mitogen-activated protein kinase (MAPK) and AKT pathways, and whether specific inhibitors can suppress CM growth in vitro. METHODS: 131 conjunctival lesions obtained from 129 patients were collected...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937145/immunoreduction-of-ocular-surface-tumours-with-intralesional-interferon-alpha-2a
#18
S E Kim, S M Salvi
PurposeTo share our initial experience in the use of intralesional interferon alpha-2a at primary presentation in ocular surface tumours as a method of immunoreduction prior to definitive surgical management.MethodsCase series of patients referred to Sheffield Ocular Oncology Service with rapidly growing ocular surface tumours, treated with intralesional interferon alpha-2a at first presentation prior to definitive surgical management.ResultsAll three patients, two with conjunctival melanoma and one with ocular surface squamous neoplasia (OSSN) demonstrated immunoreduction of tumour without any adverse side effects...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28912992/giant-conjunctival-nevus-in-a-12-year-old-child
#19
Edit Tóth-Molnár, Eszter Vizvári, Ákos Skribek, András Vörös
We describe a case of a giant conjunctival nevus presented in a 12-year-old girl with suspicious clinicomorphological appearance. The lesion was noticed by the parents at the age of 3 years as a "fleshy spot" on the bulbar conjunctiva. The lesion remained unchanged until approx. 6 months before recent admission. On slit-lamp examination, a large conjunctival lesion with variegate pigmentation and indistinct margins was detected on the superonasal part of the bulbar conjunctiva of the left eye. Intralesional cysts and vessels were detected with AS-OCT examination...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28903377/pd-l1-pd-1-expression-and-tumor-infiltrating-lymphocytes-in-conjunctival-melanoma
#20
Jinfeng Cao, Niels J Brouwer, Kate E Richards, Marina Marinkovic, Sjoerd van Duinen, Daan Hurkmans, Els M E Verdegaal, Ekaterina S Jordanova, Martine J Jager
Conjunctival melanoma (CM) is an infrequent but potentially lethal malignancy, with limited therapeutic options for metastases. Recent inhibitors of the interaction of programmed cell death protein 1 (PD-1) and its ligand PD-L1 are associated with good clinical responses in many malignancies. To investigate the therapeutic potential of targeting the PD-1/PD-L1 axis in CM, we analyzed the expression of PD-1 and PD-L1 and the density of various types of tumor-infiltrating lymphocytes (TILs) in primary CM (n = 27), using immunofluorescence staining...
August 15, 2017: Oncotarget
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