keyword
MENU ▼
Read by QxMD icon Read
search

Pathogen associated molecular patterns ( PAMPS )

keyword
https://www.readbyqxmd.com/read/27900049/toll-like-receptors-and-cutaneous-melanoma
#1
Ilaria Coati, Serena Miotto, Irene Zanetti, Mauro Alaibac
Innate immune cells recognize highly conserved pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs). Previous studies have demonstrated that PRRs also recognize endogenous molecules, termed damage-associated molecular patterns (DAMPs) that are derived from damaged cells. PRRs include Toll-like receptors (TLRs), scavenger receptors, C-type lectin receptors and nucleotide oligomerization domain-like receptors. To date, 10 TLRs have been identified in humans and each receptor responds to a different ligand...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27888386/innate-recognition-of-microbial-derived-signals-in-immunity-and-inflammation
#2
REVIEW
Yue Zhang, Chunli Liang
Microbes generate a vast array of different types of conserved structural components called pathogen-associated molecular patterns (PAMPs), which can be recognized by cells of the innate immune system. This recognition of "nonself" signatures occurs through host pattern recognition receptors (PRRs), suggesting that microbial-derived signals are good targets for innate immunity to discriminate between self- and nonself. Such PAMP-PRR interactions trigger multiple but distinct downstream signaling cascades, subsequently leading to production of proinflammatory cytokines and interferons that tailor immune responses to particular microbes...
November 23, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27885703/immunological-tolerance-part-i-of-a-report-of-a-workshop-on-foundational-concepts-of-immune-regulation
#3
Colin C Anderson, Peter Bretscher, Alexandre Corthay, Zlatko Dembic, Calliopi Havele, Zoltan A Nagy, Inger Øynebråten
This report, the first of two, arose from a one-week workshop directed at discussing concepts of immune regulation, and focuses on immunological tolerance. We first outline the major ideas we thought sufficiently plausible to provide a context for discussing more controversial issues around tolerance. We then report on our discussion of different experiments that appear paradoxical in terms of the different, contemporary models of CD4 T cell inactivation/activation, and how such observations might be resolved in terms of insights provided by these contemporary models...
November 25, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27871901/the-immunomodulation-of-a-maternal-translationally-controlled-tumor-protein-tctp-in-zhikong-scallop-chlamys-farreri
#4
Zhihao Jia, Mengqiang Wang, Feng Yue, Xiudan Wang, Lingling Wang, Linsheng Song
Translationally controlled tumor protein (TCTP) is initially described as a highly conserved protein implicated in cell growth, and it is subsequently confirmed to play important roles in mediating the innate immune response, especially the inflammatory. In the present study, the full-length cDNA sequence of a TCTP from Zhikong scallop Chlamys farreri (designed as CfTCTP) was cloned by rapid amplification of cDNA ends (RACE) technique based on the expression sequence tag (EST) analysis. It was of 1230 bp with an open reading frame (ORF) of 543 bp encoding a polypeptide of 180 amino acids...
November 18, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27851904/role-of-pathogen-associated-molecular-patterns-pamps-in-immune-responses-to-fungal-infections
#5
Mehdi Taghavi, Alireza Khosravi, Esmaeil Mortaz, Donya Nikaein, Seyyed Shamsadin Athari
Recent years have seen the rise of invasive fungal infections, which are mostly due to the increase in patients. Three major opportunistic fungal species in human are Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans that pose the biggest concern for these immunocompromised patients' mortality. The growing occurrence of opportunistic fungal infections has sparked the interest to understand defense mechanisms against pathogenic fungi. Toll-like receptors (TLRs), as a part of innate immune system, play an important role for recognizing the invading microorganisms and initiating sufficient immune responses...
November 13, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27837097/cml8-an-arabidopsis-calmodulin-like-protein-plays-a-role-in-pseudomonas-syringae-plant-immunity
#6
Xiaoyang Zhu, Eugénie Robe, Lucile Jomat, Didier Aldon, Christian Mazars, Jean-Philippe Galaud
Calcium is a universal second messenger involved in various cellular processes including plant development and stress responses. Its conversion into biological responses requires the presence of calcium sensor relays such as calmodulin (CaM) and calmodulin-like proteins (CMLs). While the role of CaM is well described, CML functions remain largely uncharacterized. Here, we show that the Arabidopsis CML8 expression is strongly and transiently induced by Pseudomonas syringae and reverse genetic approaches indicated that the over-expression of CML8 confers on plants a better resistance to pathogenic bacteria compared to wild type, knock-down and knock-out lines indicating that CML8 participates as a positive regulator in plant immunity...
November 10, 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/27825479/xopn-t3ss-effector-of-xanthomonas-axonopodis-pv-punicae-localizes-to-the-plasma-membrane-and-modulates-ros-accumulation-events-during-blight-pathogenesis-in-pomegranate
#7
Rishikesh Kumar, Madhvi Soni, Kalyan K Mondal
Bacterial blight caused by Xanthomonas axonopodis pv. punicae (Xap) is a major disease of pomegranate. Xap secretes effector proteins via type III secretion system (T3SS) to suppress pathogen-associated molecular pattern (PAMP)-triggered plant immunity (PTI). Previously we reported that XopN, a conserved effector of Xap, modulate in planta bacterial growth, and blight disease. In continuation to that here we report the deletion of XopN from Xap caused higher accumulation of reactive oxygen species (ROS) including H2O2 and O2(-)...
December 2016: Microbiological Research
https://www.readbyqxmd.com/read/27824278/modulation-of-porcine-intestinal-epitheliocytes-immunetranscriptome-response-by-lactobacillus-jensenii-tl2937
#8
H Kobayashi, L Albarracin, N Sato, P Kanmani, A K M H Kober, W Ikeda-Ohtsubo, Y Suda, T Nochi, H Aso, S Makino, H Kano, S Ohkawara, T Saito, J Villena, H Kitazawa
In order to evaluate probiotic strains applicable for the beneficial immunomodulation of the porcine gut (immunobiotics), we previously developed a porcine intestinal epitheliocyte cell line (PIE cells). Here, transcriptomic studies using PIE cells were performed considering that this information would be valuable for understanding the mechanisms involved in the protective activity of the immunobiotic strain Lactobacillus jensenii TL2937 against intestinal inflammatory damage in pigs. In addition, those studies would provide criteria for selecting biomarkers for the screening of new immunobiotic strains...
November 8, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27818661/the-role-of-purine-metabolites-as-damps-in-acute-graft-versus-host-disease
#9
REVIEW
Petya Apostolova, Robert Zeiser
Acute graft-versus-host disease (GvHD) causes high mortality in patients undergoing allogeneic hematopoietic cell transplantation. An early event in the classical pathogenesis of acute GvHD is tissue damage caused by the conditioning treatment or infection that consecutively leads to translocation of bacterial products [pathogen-associated molecular patterns (PAMPs)] into blood or lymphoid tissue, as well as danger-associated molecular patterns (DAMPs), mostly intracellular components that act as pro-inflammatory agents, once they are released into the extracellular space...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27816791/porphyromonas-gingivalis-stimulated-macrophage-subsets-exhibit-differential-induction-and-responsiveness-to-interleukin-10
#10
Andrew D Foey, Neama Habil, Khalid Al-Shaghdali, StJohn Crean
OBJECTIVES: Oral mucosal macrophages (Mϕs) determine immune responses; maintaining tolerance whilst retaining the capacity to activate defences against pathogens. Mϕ responses are determined by two distinct subsets; pro-inflammatory M1- and anti-inflammatory/regulatory M2-Mϕs. Tolerance induction is driven by M2 Mϕs, whereas M1-like Mϕs predominate in inflammation, such as that exhibited in chronic Porphyromonas gingivalis (PG) periodontal infection. Mϕ responses can be suppressed to benefit either the host or the pathogen...
October 29, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27815870/analysis-of-human-and-mouse-neutrophil-phagocytosis-by-flow-cytometry
#11
Noah Fine, Oriyah Barzilay, Michael Glogauer
Neutrophils are primary phagocytes that recognize their targets through surface chemistry, either through Pattern Recognition Receptor (PPR) interaction with Pathogen-Associated Molecular Patterns (PAMPs) or through immunoglobulin (Ig) or complement mediated recognition. Opsonization can be important for target recognition, and phagocytosis by neutrophils in whole blood can be greatly enhanced due to the presence of blood serum components and platelets. Powerful and sensitive flow cytometry based methods are presented to measure phagocytosis by human blood neutrophils and mouse peritoneal neutrophils...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27812183/imprime-pgg-mediated-anti-cancer-immune-activation-requires-immune-complex-formation
#12
Anissa S H Chan, Adria Bykowski Jonas, Xiaohong Qiu, Nadine R Ottoson, Richard M Walsh, Keith B Gorden, Ben Harrison, Peter J Maimonis, Steven M Leonardo, Kathleen E Ertelt, Michael E Danielson, Kyle S Michel, Mariana Nelson, Jeremy R Graff, Myra L Patchen, Nandita Bose
Imprime PGG (Imprime), an intravenously-administered, soluble β-glucan, has shown compelling efficacy in multiple phase 2 clinical trials with tumor targeting or anti-angiogenic antibodies. Mechanistically, Imprime acts as pathogen-associated molecular pattern (PAMP) directly activating innate immune effector cells, triggering a coordinated anti-cancer immune response. Herein, using whole blood from healthy human subjects, we show that Imprime-induced anti-cancer functionality is dependent on immune complex formation with naturally-occurring, anti-β glucan antibodies (ABA)...
2016: PloS One
https://www.readbyqxmd.com/read/27805556/-innate-receptors-and-il-17-in-the-immune-response-against-human-pathogenic-fungi
#13
REVIEW
Marìa Soledad Miro, Cecilia Vigezzi, Emilse Rodriguez, Paula Alejandra Icely, Juan Pablo Caeiro, Fernando Riera, Diana Teresa Masih, Claudia Elena Sotomayor
In recent years, the rise of human fungal infections has been associated to lack of early diagnosis, uneffective antifungal therapies and vaccines. Disturbance in immune homeostasis, which can be caused by medical interventions and immunosuppression nduced by disease, are well known as risk factors for these pathologies. Cells of the innate immune system are equipped with surface and cytoplasmic receptors for recognition of microorganisms called pattern recognition receptors (PRRs). PRRs recognize specific pathogen-associated molecular patterns (PAMPs) that are crucial for the activation and killing of pathogenic fungi by immune system...
2016: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/27795867/the-role-of-tlr2-tlr4-and-tlr9-in-the-pathogenesis-of-atherosclerosis
#14
REVIEW
Mohsin H K Roshan, Amos Tambo, Nikolai P Pace
Toll-like receptors (TLRs) are key players in the pathogenesis of inflammatory conditions including coronary arterial disease (CAD). They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and TIRF-related adaptor protein (TRAM), to mediate activation of MAPKs and NF-kappa B pathways. They are associated with the development of CAD through various mechanisms...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/27790215/the-scavenger-receptor-ssc5d-physically-interacts-with-bacteria-through-the-srcr-containing-n-terminal-domain
#15
Catarina Bessa Pereira, Markéta Bocková, Rita F Santos, Ana Mafalda Santos, Mafalda Martins de Araújo, Liliana Oliveira, Jiří Homola, Alexandre M Carmo
The scavenger receptor cysteine-rich (SRCR) family comprises a group of membrane-attached or secreted proteins that contain one or more modules/domains structurally similar to the membrane distal domain of type I macrophage scavenger receptor. Although no all-inclusive biological function has been ascribed to the SRCR family, some of these receptors have been shown to recognize pathogen-associated molecular patterns (PAMP) of bacteria, fungi, or other microbes. SSc5D is a recently described soluble SRCR receptor produced by monocytes/macrophages and T lymphocytes, consisting of an N-terminal portion, which contains five SRCR modules, and a large C-terminal mucin-like domain...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27787523/fever-range-hyperthermia-improves-the-anti-apoptotic-effect-induced-by-low-ph-on-human-neutrophils-promoting-a-proangiogenic-profile
#16
Fernando Erra Díaz, Ezequiel Dantas, Maia Cabrera, Constanza A Benítez, María V Delpino, Gabriel Duette, Julia Rubione, Norberto Sanjuan, Analía S Trevani, Jorge Geffner
Neutrophils have the shortest lifespan among leukocytes and usually die via apoptosis, limiting their deleterious potential. However, this tightly regulated cell death program can be modulated by pathogen-associated molecular patterns (PAMPs), danger-associated molecular pattern (DAMPs), and inflammatory cytokines. We have previously reported that low pH, a hallmark of inflammatory processes and solid tumors, moderately delays neutrophil apoptosis. Here we show that fever-range hyperthermia accelerates the rate of neutrophil apoptosis at neutral pH but markedly increases neutrophil survival induced by low pH...
October 27, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27780814/plant-immunity-against-viruses-antiviral-immune-receptors-in-focus
#17
REVIEW
Iara P Calil, Elizabeth P B Fontes
BACKGROUND: Among the environmental limitations that affect plant growth, viruses cause major crop losses worldwide and represent serious threats to food security. Significant advances in the field of plant-virus interactions have led to an expansion of potential strategies for genetically engineered resistance in crops during recent years. Nevertheless, the evolution of viral virulence represents a constant challenge in agriculture that has led to a continuing interest in the molecular mechanisms of plant-virus interactions that affect disease or resistance...
October 24, 2016: Annals of Botany
https://www.readbyqxmd.com/read/27776779/receptor-like-kinases-and-regulation-of-plant-innate-immunity
#18
K He, Y Wu
Plants are sessile organisms exposed constantly to potential virulent microbes seeking for full pathogenesis in hosts. Different from animals employing both adaptive and innate immune systems, plants only rely on innate immunity to detect and fight against pathogen invasions. Plant innate immunity is proposed to be a two-tiered immune system including pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity. In PTI, PAMPs, the elicitors derived from microbial pathogens, are perceived by cell surface-localized proteins, known as pattern recognition receptors (PRRs), including receptor-like kinases (RLKs) and receptor-like proteins (RLPs)...
2016: Enzymes
https://www.readbyqxmd.com/read/27769523/intercellular-communication-for-innate-immunity
#19
Tan A Nguyen, Ken C Pang, Seth L Masters
An effective innate immune response relies on the detection of pathogen associated molecular patterns (PAMPs) by various host pattern recognition receptors (PRRs) that result in the production of pro-inflammatory cytokines and chemokines. Viruses and bacteria have co-evolved with the immune system and developed multiple strategies to usurp or circumvent host machinery and blunt the innate immune response in infected cells. Recently, it has become apparent that infected or dying cells can transmit PAMPs and host PRR signalling proteins to uninfected bystander cells to thereby bypass pathogen evasion strategies, and potentiate innate immune signalling...
October 18, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27748639/increased-callose-deposition-in-plants-lacking-dynamin-related-protein-2b-is-dependent-upon-powdery-mildew-resistant-4
#20
Michelle E Leslie, Sean W Rogers, Antje Heese
Callose deposition within the cell wall is a well-documented plant immune response to pathogenic organisms as well as to pathogen-/microbe- associated molecular patterns (P/MAMPs). However, the molecular mechanisms that modulate pathogen-induced callose deposition are less understood. We reported previously that Arabidopsis plants lacking the vesicle trafficking component DYNAMIN-RELATED PROTEIN 2B (DRP2B) display increased callose deposition in response to the PAMP flg22. Here, we show that increased number of flg22-induced callose deposits in drp2b leaves is fully dependent on the callose synthase POWDERY MILDEW RESISTANT 4 (PMR4)...
November 2016: Plant Signaling & Behavior
keyword
keyword
92545
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"