keyword
MENU ▼
Read by QxMD icon Read
search

Pathogen associated molecular patterns ( PAMPS )

keyword
https://www.readbyqxmd.com/read/28916359/a-class-b-scavenger-receptor-from-eriocheir-sinensis-essr-b1-restricts-bacteria-proliferation-by-promoting-phagocytosis
#1
Yao-Meng Wu, Lei Yang, Xue-Jie Li, Lu Li, Qun Wang, Wei-Wei Li
Scavenger receptors (SRs) are important pattern recognition receptors (PRRs), which play significant roles in host defense against pathogens by identifying pathogen-associated molecular patterns (PAMPs). In this study, we report the cloning and characterization of a SR from Eriocheir sinensis (EsSR-B1) which is a 500 amino acid protein encoded by a gene comprised of 2726 nucleotides with a 1503 bp open reading frame. The domains of EsSR-B1 were found to be evolutionarily conserved. EsSR-B1 was widely detected in different tissues of E...
September 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28916358/the-functional-characterization-and-comparison-of-two-single-crd-containing-c-type-lectins-with-novel-and-typical-key-motifs-from-portunus-trituberculatus
#2
Mengmeng Huang, Changkao Mu, Yuehong Wu, Fei Ye, Dan Wang, Cong Sun, Zhengbing Lv, Bingnan Han, Chunlin Wang, Xue-Wei Xu
C-type lectins are a superfamily of Ca(2+)-dependent carbohydrate-recognition proteins, which play crucial roles in innate immunity including nonself-recognition and pathogen elimination. In the present study, two single-CRD containing C-type lectins were identified from swimming crab Portunus trituberculatus (designated as PtCTL-2 and PtCTL-3). The open reading frame (ORF) of PtCTL-2 encoded polypeptides of 485 amino acids with a signal peptide and a single carbohydrate-recognition domain (CRD), while PtCTL-3's ORF encoded polypeptides of 241 amino acids with a coiled-coil region and a single-CRD...
September 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28906208/pattern-recognition-receptors-signaling-pathways-and-dysregulation-in-canine-chronic-enteropathies-brief-review
#3
Romy M Heilmann, Karin Allenspach
Pattern-recognition receptors (PRRs) are expressed by innate immune cells and recognize pathogen-associated molecular patterns (PAMPs) as well as endogenous damage-associated molecular pattern (DAMP) molecules. With a large potential for synergism or convergence between their signaling pathways, PRRs orchestrate a complex interplay of cellular mediators and transcription factors, and thus play a central role in homeostasis and host defense. Aberrant activation of PRR signaling, mutations of the receptors and/or their downstream signaling molecules, and/or DAMP/PAMP complex-mediated receptor signaling can potentially lead to chronic auto-inflammatory diseases or development of cancer...
September 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28902164/slbir3-negatively-regulates-pamp-responses-and-cell-death-in-tomato
#4
Shuhua Huang, Shuming Nie, Shufen Wang, Jianwei Liu, Yanfeng Zhang, Xiaofeng Wang
Bri1-associated kinase 1 (BAK1)-interacting receptor-like kinase (BIR) proteins have been shown to play important roles in regulating growth and development, pathogen associated molecular pattern (PAMP)-triggered immunity (PTI) responses, and cell death in the model plant, Arabidopsis thaliana. We identified four BIR family members in tomato (Solanum lycopersicum), including SlBIR3, an ortholog of AtBIR3 from A. thaliana. SlBIR3 is predicted to encode a membrane localized non-arginine-aspartate (non-RD) kinase that, based on protein sequence, does not have autophosphorylation activity but that can be phosphorylated in vivo...
September 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28898429/tgacg-binding-factor-1-tga1-and-tga4-regulate-salicylic-acid-and-pipecolic-acid-biosynthesis-by-modulating-the-expression-of-systemic-acquired-resistance-deficient-1-sard1-and-calmodulin-binding-protein-60g-cbp60g
#5
Tongjun Sun, Lucas Busta, Qian Zhang, Pingtao Ding, Reinhard Jetter, Yuelin Zhang
Salicylic acid (SA) and pipecolic acid (Pip) play important roles in plant immunity. Here we analyzed the roles of transcription factors TGACG-BINDING FACTOR 1 (TGA1) and TGA4 in regulating SA and Pip biosynthesis in Arabidopsis thaliana. We quantified the expression levels of SYSTEMIC ACQUIRED RESISTANCE DEFICIENT 1 (SARD1) and CALMODULIN-BINDING PROTEIN 60g (CBP60g), which encode two master transcription factors of plant immunity, and the accumulation of SA and Pip in tga1-1 tga4-1 mutant plants. We tested whether SARD1 and CBP60g are direct targets of TGA1 by chromatin immunoprecipitation-polymerase chain reaction (ChIP-PCR)...
September 12, 2017: New Phytologist
https://www.readbyqxmd.com/read/28893934/tumour-viruses-and-innate-immunity
#6
REVIEW
Sharon E Hopcraft, Blossom Damania
Host cells sense viral infection through pattern recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) and stimulate an innate immune response. PRRs are localized to several different cellular compartments and are stimulated by viral proteins and nucleic acids. PRR activation initiates signal transduction events that ultimately result in an inflammatory response. Human tumour viruses, which include Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus, human papillomavirus, hepatitis C virus, hepatitis B virus, human T-cell lymphotropic virus type 1 and Merkel cell polyomavirus, are detected by several different PRRs...
October 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28893639/on-the-application-of-reverse-vaccinology-to-parasitic-diseases-a-perspective-on-feature-selection-and-ranking-of-vaccine-candidates
#7
Stephen J Goodswen, Paul J Kennedy, John T Ellis
Reverse vaccinology has the potential to rapidly advance vaccine development against parasites, but it is unclear which features studied in silico will advance vaccine development. Here we consider Neospora caninum which is a globally distributed protozoan parasite causing significant economic and reproductive loss to cattle industries worldwide. The aim of this study was to use a reverse vaccinology approach to compile a worthy vaccine candidate list for N. caninum, including proteins containing pathogen-associated molecular patterns to act as vaccine carriers...
September 8, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28887852/cd8-lineage-dendritic-cells-determine-adaptive-immune-responses-to-inflammasome-activation-upon-sterile-skin-injury
#8
Rituparna Chakraborty, Janin Chandra, Shuai Cui, Lynn Tolley, Matthew A Cooper, Mark Kendall, Ian H Frazer
The molecular links between sterile inflammation and induction of adaptive immunity have not been fully identified. Here, we examine how damage associated molecular patterns (DAMPs), as opposed to pathogen associated molecules (PAMPs), regulates the immune response to non-self-antigens presented at the site of the physical injury. Heat applied briefly to the skin invokes sterile inflammation, characterised by local cell death and caspase-1 activation without demonstrably disrupting skin integrity. Co-delivery of ovalbumin (OVA) with heat injury induces OVA-specific CD8(+) T cell responses and this is dependent on caspase-1 activation and MyD88 signalling...
September 8, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28887059/toll-like-receptor-2-and-its-roles-in-immune-responses-against-legionella-pneumophila
#9
REVIEW
Shiva Ahmadishoar, Ashraf Kariminik
Legionella pneumophila (L. pneumophila) is an intracellular bacterium which can be survived in the human macrophages phagosomes. The infectious agent is cleared in some cases and survived in others. The main mechanisms responsible for survival of L. pneumophila are yet to be clarified. It has been reported that innate immunity plays key roles in limitation and also eradication of bacterial infections. Toll like receptor 2 (TLR2) is an important cell membrane receptor which recognizes a wide range of bacterial antigens entitled pathogen associated molecular patterns (PAMPs)...
September 5, 2017: Life Sciences
https://www.readbyqxmd.com/read/28878771/coordinated-role-of-toll-like-receptor-3-and-retinoic-acid-inducible-gene-i-in-the-innate-response-of-bovine-endometrial-cells-to-virus
#10
Luisa C Carneiro, Carmen Bedford, Sarah Jacca, Alfonso Rosamilia, Vera F de Lima, Gaetano Donofrio, I Martin Sheldon, James G Cronin
Bovine herpesvirus-4 (BoHV-4) and bovine viral diarrhea virus (BVDV) infect the uterus of cattle, often resulting in reduced fertility, or abortion of the fetus, respectively. Here, exposure of primary bovine endometrial cells to BoHV-4 or BVDV modulated the production of inflammatory mediators. Viral pathogen-associated molecular patterns (PAMPs) are detected via pattern-recognition receptors (PRRs). However, the relative contribution of specific PRRs to innate immunity, during viral infection of the uterus, is unclear...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28877365/molecular-cloning-characterization-and-expression-of-immunoglobulin-d-igd-on-pathogen-challenge-and-pamps-stimulation-in-freshwater-carp-catla-catla
#11
Rajanya Banerjee, Bhakti Patel, Madhubanti Basu, Saswati S Lenka, Mahismita Paicha, Mrinal Samanta, Surajit Das
The primordial immunoglobulin class, IgD is the first non-IgM isotype discovered in teleosts. The crucial role of IgM and IgZ in imparting systemic and mucosal immunity respectively has been widely established in various fish species. However, the putative function of unique IgD isotype during pathogenic invasions has not been explored much. The present study reports the existence of IgD ortholog in freshwater carp, Catla catla and further evaluates its differential expression profile in response to bacterial, parasitic, viral antigenic exposure and (pathogen associated molecular patterns) PAMPs stimulations...
September 6, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28870670/il-1-receptor-like-1-protects-against-alcoholic-liver-injury-by-limiting-nf-%C3%AE%C2%BAb-activation-in-hepatic-macrophages
#12
Meng Wang, Guannan Shen, Liangguo Xu, Xiaodong Liu, Jared M Brown, Dechun Feng, Ruth Ann Ross, Bin Gao, Suthat Liangpunsakul, Cynthia Ju
BACKGROUND & AIM: Alcohol consumption, through increasing intestinal permeability and causing hepatocytes damage, leads to the release of pathogen- and damage-associated molecular pattern molecules (PAMPs and DAMPs). These molecules stimulate hepatic macrophages (MΦs) and activate NF-κB, resulting in inflammation and exacerbating alcoholic liver disease (ALD). However, much less is known about the mechanisms attenuating inflammation and preventing disease progression in the majority of the heavy drinkers...
September 1, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28867209/identification-and-molecular-profiling-of-dc-sign-like-from-big-belly-seahorse-hippocampus-abdominalis-inferring-its-potential-relevancy-in-host-immunity
#13
Eunyoung Jo, Don Anushka Sandaruwan Elvitigala, Qiang Wan, Minyoung Oh, Chulhong Oh, Jehee Lee
Dendritic-cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) is a C-type lectin that functions as a pattern recognition receptor by recognizing pathogen-associated molecular patterns (PAMPs). It is also involved in various events of the dendritic cell (DC) life cycle, such as DC migration, antigen capture and presentation, and T cell priming. In this study, a DC-SIGN-like gene from the big belly seahorse Hippocampus abdominalis (designated as ShDCS-like) was identified and molecularly characterized. The putative, complete ORF was found to be 1368 bp in length, encoding a protein of 462 amino acids with a molecular mass of 52...
September 1, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28866079/alternate-synthesis-to-d-glycero-%C3%AE-d-manno-heptose-1-7-biphosphate
#14
Janelle Sauvageau, Milan Bhasin, Cynthia X Guo, Itunuoluwa A Adekoya, Scott D Gray-Owen, Stefan Oscarson, Lorenzo Guazzelli, Andrew Cox
d-glycero-β-d-manno-heptose 1,7-biphosphate (HBP) is an enzymatic intermediate in the biosynthesis of the heptose component of lipopolysaccharide (LPS), and was recently revealed to be a pathogen-associated molecular pattern (PAMP) that allows detection of Gram-negative bacteria by the mammalian immune system. Cellular detection of HBP depends upon its stimulation of a cascade that leads to the phosphorylation and assembly of the TRAF-interacting with forkhead-associated domain protein A (TIFA), which activates the transcription factor NF-κB...
August 24, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28855484/recognition-of-cryptococcus-neoformans-by-pattern-recognition-receptors-and-its-role-in-host-defense-to-this-infection
#15
Ko Sato, Kazuyoshi Kawakami
Cryptococcus neoformans is a yeast-type opportunistic fungal pathogen with a capsule structure consisting of polysaccharides, such as glucuronoxylomannan and galactoxylomannan, and infects the lungs via an air-borne route. Most healthy individuals undergo asymptomatic infection with granulomatous lesions in the lungs caused by C. neoformans. However, immunocompromised hosts with severely impaired cellular immunity, such as those with acquired immune deficiency syndrome (AIDS), often suffer from disseminated infection into the central nervous system, leading to life-threatening meningoencephalitis...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28855232/molecular-mechanisms-of-inflammasome-signaling
#16
REVIEW
Anukriti Mathur, Jenni A Hayward, Si Ming Man
The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage of pro-IL-1β and -IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2 (AIM2)-like receptors (ALRs), or tripartite motif (TRIM) family receptors trigger the assembly of an inflammasome in response to pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Recent studies have revealed a multitude of host components and signals that are essential for controlling canonical and noncanonical inflammasome activation and pyroptosis...
August 30, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28841455/cardiovascular-dysfunction-in-sepsis-at-the-dawn-of-emerging-mediators
#17
REVIEW
Consolato Sergi, Fan Shen, David W Lim, Weiyong Liu, Mingyong Zhang, Brian Chiu, Vijay Anand, Ziyong Sun
Subcellular dysfunction and impaired metabolism derived from the complex interaction of cytokines and mediators with cellular involvement are on the basis of the cardiovascular response to sepsis. The lethal consequences of an infection are intimately related to its ability to spread to other organ sites and the immune system of the host. About one century ago, William Osler (1849-1919), a Canadian physician, remarkably defined the sequelae of the host response in sepsis: "except on few occasions, the patient appears to die from the body's response to infection rather than from it...
August 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28818614/the-transcription-of-atypical-protein-kinase-c-in-hemocytes-of-the-giant-freshwater-prawn-macrobrachium-rosenbergii-during-the-molt-stage-and-injection-of-pathogen-associated-compounds
#18
Yi-Chun Yeh, Chin-Chyuan Chang, Pai-Po Lee, Winton Cheng
Protein kinase C (PKC), which is involved in cell signaling pathways, comprises a family of serine/threonine kinases ubiquitously present in animals and its members are grouped on the basis of structural and activation characteristics into novel, classical, and atypical PKC forms. In this study, an atypical PKC of Macrobrachium rosenbergii, designated MraPKC, was successfully cloned, and its protein comprised structural domains similar to those of atypical PKC homologues, including the Phox and Bem1 (PB1) domain, a zinc finger phorbol-ester/DAG-type signature, protein kinase signatures, and a cAMP-dependent, cGMP-dependent, and PKC (AGC) kinase C-terminal domain...
August 14, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28815531/mitochondria-endoplasmic-reticulum-contact-sites-mediate-innate-immune-responses
#19
Takuma Misawa, Michihiro Takahama, Tatsuya Saitoh
Mitochondria and the endoplasmic reticulum (ER) are fundamental organelles that coordinate high-order cell functions. Mitochondria are centers of energy production, whereas the ER is responsible for folding, transport, and degradation of proteins. In addition to their specific functions, mitochondria and ER actively communicate with each other to promote a variety of cellular events, such as material transfer and signal transduction. Recent studies have shown the critical involvement of these organelles in regulation of the innate immune system, which functions in host defense...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28814646/the-intracellular-immune-receptor-sw-5b-confers-broad-spectrum-resistance-to-tospoviruses-through-recognition-of-a-conserved-21-amino-acid-viral-effector-epitope
#20
Min Zhu, Lei Jiang, Baohui Bai, Wenyang Zhao, Xiaojiao Chen, Jia Li, Yong Liu, Zhengqiang Chen, Boting Wang, Chunli Wang, Qian Wu, Qian-Hua Shen, Savithramma P Dinesh-Kumar, Xiaorong Tao
Plants use both cell surface-resident pattern-recognition receptors (PRRs) and intracellular nucleotide-binding leucine-rich repeat (NLR) receptors to detect various pathogens. Plant PRRs typically recognize conserved pathogen-associated molecular patterns (PAMPs) to provide broad-spectrum resistance. By contrast, plant NLRs generally detect pathogen strain-specific effectors and confer race-specific resistance. Here, we demonstrate that the tomato NLR Sw-5b confers broad-spectrum resistance against American type tospoviruses by recognizing a conserved 21-amino-acid peptide region within viral movement protein NSm (NSm21)...
August 16, 2017: Plant Cell
keyword
keyword
92545
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"