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mercury toxicology clinical presentation

Pınar Gençpınar, Başak Büyüktahtakın, Zeynep İbişoğlu, Şakir Genç, Aygen Yılmaz, Ercan Mıhçı
Mercury poisoning is a rare but fatal toxicologic emergency. Neurologic manifestations involving the central nervous system are seen usually with chronic mercury intoxication. The most commonly seen complaints are headache, tremor, impaired cognitive skills, weakness, muscle atrophy, and paresthesia. Here, we present a male patient who was chronically exposed to elemental mercury and had papilledema and intracranial hypertension without parenchymal lesion in the central nervous system. A 12-year-old male patient was referred to our emergency room because of severe fatigue, generalized muscle pain and weakness, which was present for a month...
May 2015: Journal of Child Neurology
Cristina Taut
Dental amalgam is a reliable and effective restorative material with a well-established role in modern dentistry. Throughout the years its mercury content and the risks posed to human health were main topics of interest for many scientists. This paper offers a review of the scientific literature on the health and environmental impact of mercury in dentistry published over the last decade. A variety of peer-reviewed, epidemiological and large-scale clinical studies on dental amalgam, as well as published reports of professional and governmental bodies, were organised thematically and analysed...
December 2013: Journal of the Irish Dental Association
T Kobidze, O Urushadze, I Afandiyev, G Nemsadze, D Loladze
Intentional self-injection of metallic mercury case report is presented. A 22 year old man with a past medical history of ethylene glycol suicidal poisoning was admitted to a Acad. N. Kipshidze Central University Clinic in Tbilisi, four months after deliberate intravenous injection of an unknown quantity of metallic mercury from several thermometers into his antecubital vein. After 2 months of asymptomatic period, the patient began to complain of pain and tremor in limbs, fatigue and skin rash. CT scan of the thorax and the abdomen confirmed multiple small opacities of metallic density in both lungs, liver and right kidney...
January 2014: Georgian Medical News
Ming-Ling Wu, Jou-Fang Deng, Kon-Ping Lin, Wei-Jen Tsai
BACKGROUND: Metal poisonings through a mucocutaneous route are reported rarely in the literature. METHODS: We report 2 cases of heavy metal intoxication from inappropriate use of Chinese mineral medicines confirmed by toxicologic investigations. RESULTS: A 51-year-old man developed perianal gangrene and a high fever after a 2-week anal use of hong-dan herbal mixtures for anal fistula. He presented gastrointestinal and constitutional symptoms, followed by skin rash, anemia, hair loss, peripheral neuropathy, and muscle atrophy...
May 2013: American Journal of Medicine
Anna Bazylewicz, Tomasz Kłopotowski, Mariusz Kicka, Łukasz Miśkiewicz, Sebastian Picheta
UNLABELLED: Mercury is a heavy metal found in nature in three forms: metallic mercury, organic and inorganic compounds. It is a general protoplasmatic toxin. The pathophysiology of mercury toxicity is related to its binding to sulfhydryl groups of different receptor proteins and cellular enzymes, interrupting cellular metabolism and in this way causing cell death. In the paper we present a case of 57-year-old woman, who was admitted due to suspicion of metallic mercury parenteral poisoning...
2012: Przegla̧d Lekarski
Zeynep Türkmen, Neylan Ziyalar, Itir Tari, Selda Mercan, Sinan Mahir Kayiran, Dicle Sener, Salih Cengiz, Necla Akçakaya
Munchausen syndrome by proxy is a kind of child abuse in which affected children are often hospitalized for long periods and endure repetitive, painful and expensive diagnostic attempts. We present herein two toxicologically confirmed cases of Munchausen syndrome by proxy. Case 1 is a 16-month-old male who had fever, peripheral cyanosis, tremor, and reported cardiac arrest. Symptoms recurred in the hospital when the mother administered fluids. Toxicology detected 3.5 ng/ml mercury (Hg) in the fluid and 9.4 microg Hg/g creatinine in the urine...
May 2012: Turkish Journal of Pediatrics
Serife Gul Oz, Mukaddes Tozlu, Songul Siddika Yalcin, Tumay Sozen, Gulay Sain Guven
Acute mercury vapor poisoning is a rare but fatal toxicological emergency. People are exposed to mercury in daily life by the way of foods, vaccines, antiseptics, ointments, amalgam or occupation. We present here, the clinical picture and management of four members of the same family who were exposed to elemental mercury. Three of the family members were seen in another hospital with malaise, fever, eritematous rash and pulmonary problems. Their questioning revealed the mercury exposure. Having a suspicion of heavy metal intoxication, blood and urine mercury levels were measured and mercury intoxication was diagnosed...
August 2012: Inhalation Toxicology
Xinrui Zhou, Qi Wang, Xiaoda Yang
Cinnabar has been an important traditional Chinese medicine as a sedative and soporific agent for more than 2000 years. It is a naturally occurring mercuric sulfide and containing more than 96% mercuric sulfide (HgS). There are about 10% -30% Chinese patent medicines containing cinnabar according to the Pharmacopoeia of China (2005). It's hard to deny that cinnabar has therapeutic effect in clinic practice. However, cinnabar's extraordinary high containing mercury makes people hesitate to use. Furthermore, the abuse of cinnabar, which caused intoxication cases, has been reported occasionally...
November 2009: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Yang Cao, Aimin Chen, Robert L Jones, Jerilynn Radcliffe, Kathleen L Caldwell, Kim N Dietrich, Walter J Rogan
Because the toxicological effects of mercury (Hg) are more serious in the developing central nervous system of children than adults, there are growing concerns about prenatal and early childhood Hg exposure. This study examined postnatal methylmercury (MeHg) exposure and cognition and behavior in 780 children enrolled in the Treatment of Lead (Pb)-exposed Children clinical trial (TLC) with 396 children allocated to the succimer and 384 to the placebo groups. Mercury exposure was determined from analyses of blood drawn 1 week before randomization and 1 week after treatment began when succimer had its maximal effect on blood Pb (PbB)...
January 2010: Neurotoxicology
Sharon L Deem, Terry M Norton, Mark Mitchell, Al Segars, A Rick Alleman, Carolyn Cray, Robert H Poppenga, Mark Dodd, William B Karesh
The health status of 83 loggerhead sea turtles (Caretta caretta; 39 foraging, 31 nesting, and 13 stranded turtles) was analyzed using physical examinations, hematology, plasma biochemistry, plasma protein electrophoresis, and toxicologic parameters. Significant differences were noted in a number of health parameters between turtles exhibiting each of these behaviors. On physical examinations, stranded turtles had the highest prevalence of heavy carapace epibiont loads, miscellaneous abnormalities, emaciation, and weakness...
January 2009: Journal of Wildlife Diseases
S H Jadhav, S N Sarkar, M Aggarwal, H C Tripathi
Exposure of animals and humans to different metal components through contaminated drinking water can result in a wide range of adverse clinical conditions. Toxicological consequences arising from the concurrent repeated exposure to multiple metal contaminants are not known. The purpose of the present study was to evaluate the oxidative stress-inducing potential of a mixture of eight metals (arsenic, cadmium, lead, mercury, chromium, nickel, manganese, iron), representative of groundwater contamination in different areas of India, in erythrocytes of male rats subchronically exposed to environmentally relevant doses via drinking water...
January 2007: Archives of Environmental Contamination and Toxicology
L I G Worthley
OBJECTIVE: To review the diagnosis and management of drug overdose and poisonings in a two-part presentation. DATA SOURCES: A review of articles reported on drug overdose and poisonings. SUMMARY OF REVIEW: In patients who attempt suicide it is usual for the overdose to be a therapeutic agent, although in the severely mentally disturbed patient the agent may be an unusual poison. As with any overdose, the most important aspects in the management is the maintenance of the patient's airway, ventilation and circulation, while the toxin is metabolised and excreted...
September 2002: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
Robert A Nash
The effects of toxicant metals on human health have been reported in peer-reviewed literature with increasing frequency. Toxicant metals are present in many diseases of aging, especially vascular diseases. Toxicant metals are a natural environmental phenomenon as well as a byproduct of industrialization. The historical experience of toxicologists who treated individuals poisoned by acutely toxicant metals is waning; very few of these cases have been reported during the past 30 years in the US. Researchers with a special interest in clinical metal toxicology have noticed a clinical correlation between metal detoxification by chelation therapy and clinical improvement of vascular diseases...
July 2005: Alternative Therapies in Health and Medicine
Michael Shannon, Alan Woolf, Rose Goldman
BACKGROUND/OBJECTIVE: As a result of an increasing desire among physicians and parents for clinical centers that can evaluate children with known or suspected exposures to environmental toxicants, a network of federally funded "pediatric environmental health specialty units" has recently been created. This descriptive study profiles the children seen in one unit of this program. SETTING: A New England, university-affiliated Pediatric Environmental Health Center (PEHC)...
January 2003: Ambulatory Pediatrics: the Official Journal of the Ambulatory Pediatric Association
Nurka Pranjić, Jasenko Karamehić, Farid Ljuca, Zlata Zigić, Mensura Ascerić
In this review we used the published data on depleted uranium (experimental and epidemiological) from the current literature. Depleted uranium is a toxic heavy metal that in high dose may cause poisoning and health effects as those caused by lead, mercury, and chromium. It is slightly radioactive. The aim of this review was to select, to arrange, to present references of scientific papers, and to summarise the data in order to give a comprehensive image of the results of toxicological studies on depleted uranium that have been done on animals (including carcinogenic activity)...
2002: Medicinski Arhiv
M T Solis, E Yuen, P S Cortez, P J Goebel
Acute mercury vapor poisoning is an uncommon but potentially fatal toxicologic emergency. A case series is presented of a family who became exposed to mercury vapor as a result of home gold ore processing. The severity of the poisoning necessitated mechanical ventilation in three of the eight patients who were exposed. Despite aggressive management, two patients died, because their clinical course was dominated by irreversible pulmonary toxicity. The remaining survivors developed varying degrees of mercury toxicity...
September 2000: American Journal of Emergency Medicine
R Cornelis, B Heinzow, R F Herber, J M Christensen, O M Poulsen, E Sabbioni, D M Templeton, Y Thomassen, M Vahter, O Vesterberg
This paper presents an organized system for element-specific sample collection and handling of human blood (whole blood, serum or plasma, packed cells or erythrocytes) and urine also indicating a proper definition of the subject and sample. Harmonized procedures for collection, preparation, analysis and quality control are suggested. The aim is to assist scientists worldwide to produce comparable data which will be useful on a regional, national and international scale. The guidelines are directed to the elements aluminium, arsenic, cadmium, chromium, cobalt, copper, lead, lithium, manganese, mercury, nickel, selenium and zinc...
June 1996: Journal of Trace Elements in Medicine and Biology
I Cinca, I Dumitrescu, P Onaca, A Serbänescu, B Nestorescu
Four case reports are presented of patients who ate the meat of a hog inadvertently fed seed treated with fungicides containing ethyl mercury chloride. The clinical, electrophysiological, and toxicological, and in two of the patients the pathological data, showed that this organic mercury compound has a very high toxicity not only for the brain, but also for the spinal motoneurones, peripheral nerves, skeletal muscles, and myocardium.
February 1980: Journal of Neurology, Neurosurgery, and Psychiatry
E Walter
Elementary mercury is usually intravenously injected with suicidal intent. It is floated to the heart and lungs but is also deposited in the abdominal organs. Case histories presented in the literature so far have been followed up clinically and roentgenologically for up to three years. We report one patient attempting suicidal mercury injection, whom we were able to follow up for 10 years. It could be demonstrated that quite in contrast to former suggestions elementary mercury is dissolved and oxidised in the body...
January 1986: Der Radiologe
P Heeg
The mucous membranes colonized by high numbers of microorganisms play a major role as a source of nosocomial infections. According to clinical requirements it seems reasonable to distinguish three modes of application of antiseptics: 1. single prophylactic (prior to mucosa-penetrating interventions), 2. repeated periodical (wound care, treatment of oral cavity in intubated patients, decontamination of granulocytopenic patients), 3. therapeutic (local mucosal infections) including treatment of carriers to prevent transmission and spread of pathogens...
February 1990: Zeitschrift Für die Gesamte Hygiene und Ihre Grenzgebiete
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