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Chetan U Phadke, Shreeharsh S Godbole, Atul D Sajgure, Tushar A Dighe, Charan B Bale
Anti-glomerular basement membrane (GBM) disease is a form of rapidly progressive glomerulonephritis with acute deterioration of kidney function. Atypical forms of this disease have been described which do not show positive serology for the classical anti-GBM antibody (Ab) but their presence on kidney biopsies. Furthermore, concomitantly any other separate glomerular pathology along with anti-GBM disease has been only rarely seen. A 40-year-old male patient presented with complaints of lower limb swelling and hematuria...
March 2024: Curēus
#2
JOURNAL ARTICLE
Xiaojiao Guo, Xuan Tie, Yuyu Zhang, Yemei Dai, Shulei Yao, Xi Qiao, Lihua Wang, Xiaole Su
Introduction This study evaluated the phenotypic and pathology characteristics of patients undergoing kidney biopsy at a single center, while also determining the frequency and factors associated with clinical outcomes. Methods The incidence and distribution of biopsy-proven kidney diseases in 2000-2019 were surveyed. Consecutive individuals diagnosed with membranous nephropathy (MN), immunoglobulin A nephropathy (IgAN), and minimal change disease (MCD) between August 2015 and December 2019 were enrolled in the prospective two-year follow-up study...
April 12, 2024: Kidney & Blood Pressure Research
#3
JOURNAL ARTICLE
Hyung Woo Kim, Eun Hwa Kim, Yun Ho Roh, Young Su Joo, Minseob Eom, Han Seong Kim, Mi Seon Kang, HoeIn Jeong, Beom Jin Lim, Seung Hyeok Han, Minsun Jung
BACKGROUND: Despite the widespread impact of the severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) and vaccination in South Korea, our understanding of kidney diseases following these events remains limited. We aimed to address this gap by investigating the characteristics of glomerular diseases following the COVID-19 infection and vaccination in South Korea. METHODS: Data from multiple centers were used to identify de novo glomerulonephritis (GN) cases with suspected onset following COVID-19 infection or vaccination...
March 2024: Kidney Research and Clinical Practice
#4
JOURNAL ARTICLE
Zhanfei Wu, Hongfen Li, Youxia Liu, Fanghao Wang, Yue Xing, Wenying Li, Junya Jia, Tiekun Yan
Objective To investigate whether immunosuppressive therapy is beneficial in IgA nephropathy (IgAN) patients with eGFR < 45ml/min/1.73m2. Methods This retrospective study involved 110 IgAN patients for whom clinical data was available; of these, 90 had complete follow-up data. Patients were grouped based on whether they received immunotherapy during follow-up, their renal function, proteinuria levels, and the percentage of crescentic glomeruli observed at the time of renal biopsy. Results The mean eGFR for the participants was 32...
April 2, 2024: Kidney & Blood Pressure Research
#5
Esra Karabağ Yılmaz, Seha Saygılı, Gülüstan Musayeva, Rüveyda Gülmez, Ayşe Ağbaş, Yasemin Özlük, Nur Canpolat
BACKGROUND: Relapses or new-onset IgA nephropathy (IgAN) have been documented in patients after vaccination against SARS-CoV-2; however, only one adult patient has been reported in whom pre-existing IgAN worsened during coronavirus disease 2019 (COVID-19). CASE: We present the first pediatric case with biopsy-proven IgAN and genetically confirmed Alport syndrome, who developed end-stage kidney disease after an exacerbation of IgAN associated with COVID-19. The patient`s basal serum creatinine was 0...
2024: Turkish Journal of Pediatrics
#6
REVIEW
Zewei Chen, Dechao Xu, Fangzheng Cui, Huihui Hou, Zhiguo Mao, Xiang Gao
Anti-glomerular basement membrane (GBM) disease is a rare autoimmune condition characterized by the presence of positive anti-GBM autoantibodies, linear deposition of immunoglobulin G (IgG) along the GBM and severe kidney injury. In a limited number of cases, the association of anti-GBM disease with other glomerulonephritis has been reported. Herein, we present the case of a 66-year-old female patient with progressive worsen kidney function and decreased urine output. A renal biopsy revealed crescent glomerulonephritis with lineal IgG deposition along the GBM and mesangial IgA deposition, which supported the diagnosis of concurrent anti-GBM disease and IgA nephropathy (IgAN)...
December 2024: Renal Failure
#7
REVIEW
Yongze Zhuang, Hailing Lu, Junxia Li
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease, and the "four-hit" theory represents its currently accepted pathogenic mechanism. Mucosal immunity triggered by infections in the respiratory tract, intestines, or other areas leads to antigen presentation, T cell stimulation, B cell maturation, and the production of IgA-producing plasma cells. The proteins B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are involved in this process, and alternative complement and lectin pathway activation are also part of the pathogenic mechanism...
March 2024: Chronic Diseases and Translational Medicine
#8
Georgina Oakman, Cindy Ong
BACKGROUND: The anti-thyroid medication propylthiouracil (PTU) is a recognised cause of drug-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Pauci-immune crescentic glomerulonephritis is the characteristic feature of this condition on renal biopsy. We present a case of PTU-induced AAV with the unusual histological finding of overlap IgA nephropathy (IgAN) in a young female with treatment-resistant Graves' disease. CASE REPORT: A 26-year-old female presented with an acute kidney injury, macroscopic haematuria, and proteinuria 14 months after starting PTU for Graves' disease...
2024: Case Reports in Nephrology and Dialysis
#9
Aref Zribi, Amro Nagy, Marwa Al Riyami, Ikram A Burney
Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min...
February 2024: Sultan Qaboos University Medical Journal
#10
JOURNAL ARTICLE
Zhi-Yu Duan, Ru Bu, Shuang Liang, Xi-Zhao Chen, Chun Zhang, Qiu-Yue Zhang, Ji-Jun Li, Xiang-Mei Chen, Guang-Yan Cai
BACKGROUND: For IgA nephropathy (IgAN), tubular atrophy/interstitial fibrosis is the most important prognostic pathological indicator in the mesangial and endocapillary hypercellularity, segmental sclerosis, interstitial fibrosis/tubular atrophy, and presence of crescents (MEST-C) score. The identification of non-invasive biomarkers for tubular atrophy/interstitial fibrosis would aid clinical monitoring of IgAN progression and improve patient prognosis. METHODS: The study included 188 patients with primary IgAN in separate confirmation and validation cohorts...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Pranjal Kalita, Jaya Mishra, Biswajit Dey, Vandana Raphael, Monaliza Lyngdoh, Himesh Barman, Animesh Mishra
Immunoglobulin A (IgA) nephropathy is the most common primary glomerulopathy, with wide variation in its prevalence as well as clinical symptoms. Among the laboratory parameters, increased serum creatinine (SCr) levels, mean arterial pressure (MAP), and a decreased estimated glomerular filtration rate (eGFR) point toward poorer renal function. The Oxford 2016 scoring system for IgA nephropathy identified various histopathological variables, which serve as indicators of renal outcomes. There is a paucity of studies on the prevalence as well as the various clinical laboratory parameters correlating with the 2016 Oxford scoring system in northeastern India...
July 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
#12
JOURNAL ARTICLE
Joel D Murphy, Tiffany N Caza, Clarissa A Cassol, Aaron Storey, Josephine M Ambruzs, Christie Boils, Patrick D Walker, Shree Sharma, Nidia Messias, Randolph Hennigar, Nicole K Andeen, Christine VanBeek, Matthew Palmer, Lakshna Sankar, Pooja Sanghi, Kumar Dinesh, Lance Dicker, Anatoly Urisman, Christopher P Larsen
INTRODUCTION: Antibrush border antibody disease (ABBA) is an autoimmune tubulointerstitial kidney disease that primarily affects older individuals and results in progressive kidney failure. It is rare with only 20 reported cases. Here, we describe a case series to further define the clinicopathologic spectrum and natural history, and to inform management. METHODS: We identified 67 patients with ABBA who underwent kidney biopsy, including 65 native and 2 transplants...
February 2024: KI Reports
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JOURNAL ARTICLE
Paraskevi Pavlakou, Harikleia Gakiopoulou, Sonja Djudjaj, Kostas Palamaris, Maria Stella Trivyza, Kostas Stylianou, Dimitrios S Goumenos, Evangelos Papachristou, Marios Papasotiriou
Keratins are the main components of the cell cytoskeleton of epithelial cells. Epithelial cells under stressful stimuli react by modifying their keratin expression pattern. Glomerular diseases are pathological conditions that may lead to loss of kidney function if not timely diagnosed and treated properly. This study aims to examine glomerular and tubular keratin expression in podocytopathies, ANCA-associated vasculitis, and IgA nephropathy and how this expression correlates to clinical outcomes. We included 45 patients with podocytopathies (minimal change disease and focal segmental glomerulosclerosis), ANCA-associated vasculitis, and IgA nephropathy, with or without crescentic lesions, and healthy controls...
February 2, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Samar Abd ElHafeez, Anneke Kramer, Mustafa Arici, Miha Arnol, Anders Åsberg, Samira Bell, Julie Belliere, Carmen Díaz Corte, Gema Fernández Fresnedo, Marc Hemmelder, Line Heylen, Kristine Hommel, Julia Kerschbaum, Radomir Naumović, Dorothea Nitsch, Rafael Santamaria, Patrik Finne, Runolfur Palsson, Maria Pippias, Halima Resic, Mai Rosenberg, Carmen Santiuste de Pablos, Mårten Segelmark, Søren Schwartz Sørensen, Maria Jose Soler, Enrico Vidal, Kitty J Jager, Alberto Ortiz, Vianda S Stel
BACKGROUND AND HYPOTHESIS: Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. METHODS: We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD due to PGD between 2000 and 2019. ERA primary renal disease codes were used to define six PGD subgroups...
February 7, 2024: Nephrology, Dialysis, Transplantation
#15
JOURNAL ARTICLE
Hiroshi Yamashita, Masahiro Okabe, Hiroyuki Ueda, Yoichi Miyazaki, Takashi Yokoo
No abstract text is available yet for this article.
January 31, 2024: Clinical Nephrology
#16
JOURNAL ARTICLE
Qian Zhang, Hong Pan, Xue-Yan Bian, Jin-Han Yu, Long-Long Wu, Yi-Dan Chen, Li Li, Ling-Xi Ji, Ya-Li Yu, Fei Han, Jian Huang, Yong-Fei Wang, Yi Yang
IgA nephropathy (IgAN) is an immune-mediated glomerulonephritis, posing a challenge for the long-term management. It is crucial to monitor the disease's activity over the disease course. Crescent lesions have been known as an active lesion associated with immune activity. We aimed to develop the Crescent Calculator to aid clinicians in making timely and well-informed decisions throughout the long-term disease course, such as renal biopsies and immunosuppressive therapy. 1,761 patients with biopsy-proven IgAN were recruited from four medical centers in Zhejiang Province, China...
January 23, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
#17
JOURNAL ARTICLE
Sean J Barbour, Rosanna Coppo, Lee Er, Evangeline Pillebout, Maria Luisa Russo, Charles E Alpers, Agnes B Fogo, Franco Ferrario, J Charles Jennette, Ian S D Roberts, H Terence Cook, Jie Ding, Baige Su, Xuhui Zhong, Fernando C Fervenza, Ladan Zand, Licia Peruzzi, Laura Lucchetti, Ritsuko Katafuchi, Yuko Shima, Norishige Yoshikawa, Daisuke Ichikawa, Yusuke Suzuki, Luisa Murer, Robert J Wyatt, Catherine Park, Raoul D Nelson, JoAnn H Narus, Scott Wenderfer, Duvuru Geetha, Eric Daugas, Renato C Monteiro, Shinya Nakatani, Antonio Mastrangelo, Matti Nuutinen, Mikael Koskela, Lutz T Weber, Agnes Hackl, Martin Pohl, Carmine Pecoraro, Nobuo Tsuboi, Takashi Yokoo, Ito Takafumi, Shouichi Fujimoto, Giovanni Conti, Domenico Santoro, Marco Materassi, Hong Zhang, Sufang Shi, Zhi-Hong Liu, Vladimir Tesar, Dita Maixnerova, Carmen Avila-Casado, Ingeborg Bajema, Antonella Barreca, Jan U Becker, Jessica M Comstock, Virgilius Cornea, Karen Eldin, Loren Herrera Hernandez, Jean Hou, Kensuke Joh, Mercury Lin, Nidia Messias, Andrea Onetti Muda, Fabio Pagni, Francesca Diomedi-Camassei, Heikki Tokola, Maria D'Armiento, Maximilian Seidl, Avi Rosenberg, Aurélie Sannier, Maria Fernanda Soares, Suxia Wang, Caihong Zeng, Mark Haas
BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists...
April 1, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#18
JOURNAL ARTICLE
Kartik Ganesh, J K Jayaram, Renu Mariam Thomas, Tena Thomas Abraham, Jithin S Kumar, Sunita S Simon, M Abi Abraham
AIMS AND BACKGROUND: To describe the prevalence of IgA deposits (IgAD) in renal allografts in a cohort of renal transplant recipients and to analyze their management strategies and histopathology. To assess graft function and proteinuria after 1 year of follow-up. MATERIALS AND METHODS: A prospective longitudinal follow-up study was carried out in VPS Lakeshore Hospital and Research Centre, Kochi, Kerala, over a period of 5 years (July 2015 to June 2020). Kidney transplant recipients with allograft biopsies that reported IgAD on immunofluorescence were included in the study...
2024: Transplantation Proceedings
#19
JOURNAL ARTICLE
Masahiro Okabe, Kentaro Koike, Izumi Yamamoto, Nobuo Tsuboi, Taiji Matsusaka, Takashi Yokoo
BACKGROUND: In human glomerular diseases, visualizing podocyte injury is desirable since podocytes do not regenerate and podocyte injury leads to podocyte loss. Herein, we investigated the utility of immunostaining for early growth response 1 (EGR1), which is expressed in injured podocytes from the early stages of injury in animal experiments, as a podocyte injury marker in human glomerular diseases. METHODS: This study included 102 patients with biopsy-proven glomerular diseases between 2018 and 2021...
January 2024: Clinical Kidney Journal
#20
JOURNAL ARTICLE
Yu-Lin Huang, Xiao Qi Liu, Yang Huang, Feng Yong Jin, Qing Zhao, Qin Yi Wu, Kun Ling Ma
BACKGROUND: Machine learning (ML) models can help assisting diagnosis by rapidly localising and classifying regions of interest (ROIs) within whole slide images (WSIs). Effective ML models for clinical decision support require a substantial dataset of 'real' data, and in reality, it should be robust, user-friendly and universally applicable. METHODS: WSIs of primary IgAN were collected and annotated. The H-AI-L algorithm which could facilitate direct WSI viewing and potential ROI detection for clinicians was built on the cloud server of matpool, a shared internet-based service platform...
December 18, 2023: Journal of Clinical Pathology
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