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Liver imaging

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https://www.readbyqxmd.com/read/28822820/utility-of-3d-reconstruction-of-2d-liver-computed-tomography-magnetic-resonance-images-as-a-surgical-planning-tool-for-residents-in-liver-resection-surgery
#1
Caitlin T Yeo, Andrew MacDonald, Tamas Ungi, Andras Lasso, Diederick Jalink, Boris Zevin, Gabor Fichtinger, Sulaiman Nanji
OBJECTIVE: A fundamental aspect of surgical planning in liver resections is the identification of key vessel tributaries to preserve healthy liver tissue while fully resecting the tumor(s). Current surgical planning relies primarily on the surgeon's ability to mentally reconstruct 2D computed tomography/magnetic resonance (CT/MR) images into 3D and plan resection margins. This creates significant cognitive load, especially for trainees, as it relies on image interpretation, anatomical and surgical knowledge, experience, and spatial sense...
August 16, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28822108/semi-quantitative-metabolic-values-on-fdg-pet-ct-including-extracardiac-sites-of-disease-as-a-predictor-of-treatment-course-in-patients-with-cardiac-sarcoidosis
#2
Mitsutomi Ishiyama, Laurie A Soine, Hubert J Vesselle
BACKGROUND: Cardiac sarcoidosis is associated with major adverse cardiac events including cardiac arrest, for which anti-inflammatory treatment is indicated. Oral corticosteroid is the mainstay among treatment options; however, adverse effects are a major concern with long-term use. It would be beneficial for providers to predict treatment response and prognosis for proper management strategy of sarcoidosis, though it remains challenging. Fluorine (F)-18 fluorodeoxyglucose (FDG)-positron emission tomography(PET)/computed tomography(CT) has an advantage over anatomical imaging in providing semi-quantitative functional parameters such as standard uptake value (SUV), metabolic volume, and total lesion glycolysis (TLG), which are well-established biomarkers in oncology...
August 18, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28819825/ceus-li-rads-algorithm-implementation-and-key-differences-from-ct-mri
#3
Stephanie R Wilson, Andrej Lyshchik, Fabio Piscaglia, David Cosgrove, Hyun-Jung Jang, Claude Sirlin, Christoph F Dietrich, Tae Kyoung Kim, Juergen K Willmann, Yuko Kono
Contrast-enhanced ultrasound (CEUS) is a specialized form of ultrasound (US) performed with an intravenous injection of microbubble contrast agents. It has been successfully used for a variety of applications including characterization of liver tumors. In April 2014, the American College of Radiology (ACR) convened a working group of international experts to develop ACR CEUS Liver Imaging Reporting and Data System (CEUS LI-RADS). An initial version of CEUS LI-RADS was published in August 2016. Although the CEUS LI-RADS concept and principles for liver lesion characterization, using dynamic contrast enhancement features, are similar to those for CT or MRI, there are significant differences between CT/MRI and CEUS LI-RADS...
August 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28819657/dendrimers-meet-zwitterions-development-of-a-unique-antifouling-nanoplatform-for-enhanced-blood-pool-lymph-node-and-tumor-ct-imaging
#4
Zhijuan Xiong, Yue Wang, Jingyi Zhu, Xin Li, Yao He, Jiao Qu, Mingwu Shen, Jindong Xia, Xiangyang Shi
We report the synthesis and characterization of antifouling zwitterion carboxybetaine acrylamide (CBAA)-modified dendrimer-entrapped gold nanoparticles (Au DENPs) for enhanced CT imaging applications. The CBAA-modified nanodevice displays a better protein resistance property, less macrophage cellular uptake and liver accumulation, and longer blood half-delay time than the PEGylated counterpart material, thereby enabling enhanced blood pool, lymph node, and tumor CT imaging.
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28818992/long-half-life-89-zr-labeled-radiotracers-can-guide-in-suite-percutaneous-molecular-imaging-pet-ct-guided-biopsies-without-reinjection-of-radiotracer
#5
Francois H Cornelis, Jeremy Durack, Neeta Pandit-Taskar, Gary A Ulaner, Jason S Lewis, Michael J Morris, Stephen B Solomon
Rationale: To evaluate the feasibility of in suite Zr89 labeled radiotracer positron emission tomography-computed tomography (PET/CT)-guided biopsies performed without reinjection. Methods: From 2013-2016, 12 patients (7 males, 5 females; mean age 61 years, range 40-75) with suspected metastatic prostate or breast carcinoma on either imaging or biochemical progression underwent 14 percutaneous biopsies after diagnostic PET/CT using (89)Zr labeled radiotracers (mean dose: 180MBq; range: 126-189MBq) targeting prostate specific membrane antigen (PSMA) (n = 7) or human epidermal growth factor receptor 2 (HER2) (n = 5)...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818987/response-assessment-of-68-ga-dota-e-c-rgdfk-2-pet-ct-for-lung-adenocarcinoma-patients-treated-with-nintedanib-plus-docetaxel
#6
Oscar Arrieta, Francisco O Garcia-Perez, David Michel-Tello, Laura-Alejandra Ramirez-Tirado, Quetzali Pitalua-Cortes, Graciela Cruz-Rico, Eleazar-Omar Macedo-Perez, Andres F Cardona, Jaime de la Garza-Salazar
Nintedanib is an oral angiokinase inhibitor used as a second-line treatment for non-small-cell lung cancer (NSCLC). New radiotracers, such as (68)Ga-DOTA-E-[c(RGDfK)]2, that target αvβ3 integrin might impact the clinical practice as a non-invasive method for assessing angiogenesis inhibitors. Methods: From July 2014 through October 2015, 38 patients received second-line nintedanib plus docetaxel. All the patients underwent PET/CT with (68)Ga-DOTA-E-[c(RGDfK)]2 radiotracer and blood-sample tests to quantify angiogenesis factors (FGF, VEGF and PDGF-AB) prior to and after completing 2 therapy cycles...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818763/the-qualitative-and-quantitative-image-analysis-of-mr-imaging-in-patients-with-acute-on-chronic-liver-failure
#7
Tae Wook Kang, Mimi Kim, Young Kon Kim, Seong Hyun Kim, Dong Hyun Sinn, Kyunga Kim
PURPOSE: To evaluate the distinctive features of ACLF and chronic liver disease (CLD) on MR images using quantitative and qualitative analyses. METHODS: Twelve patients with ACLF and 36 patients with CLD who had undergone MR images were included. MR imaging findings from both groups were assessed. RESULTS: Gallbladder edema, esophageal varix, and ascites were significantly more prevalent in the ACLF group (all P-values <0.05). The liver to muscle SI ratio on T2-WI was significantly higher in the ACLF group (P=0...
August 10, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28818109/metastatic-colorectal-cancer-responsive-to-regorafenib-for-2-years-a-case-report
#8
Kenji Yoshino, Dai Manaka, Ryo Kudo, Shunpei Kanai, Eisei Mitsuoka, Satoshi Kanto, Shinya Hamasu, Sayuri Konishi, Ryuta Nishitai
BACKGROUND: Regorafenib is an oral multikinase inhibitor that has been demonstrated as clinically effective in patients with metastatic colorectal cancer in phase III studies. Although disease control was achieved in 40% of the pretreated patients with metastatic colorectal cancer in the pivotal studies, radiological response has rarely been reported. Severe adverse events associated with regorafenib are known to occur during the first and second courses of treatment. We present a case of a 62-year-old Japanese patient whose metastatic colorectal cancer has been responding to treatment with regorafenib for 2 years...
August 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28817195/vertical-off-centering-affects-organ-dose-in-chest-ct-evidence-from-monte-carlo-simulations-in-anthropomorphic-phantoms
#9
Natalia Saltybaeva, Hatem Alkadhi
PURPOSE: The objective of our study was to assess the effect of patient vertical off-centering on organ dose in chest CT with tube current modulation. METHODS: For this purpose, anthropomorphic phantoms representing adult male, female and overweight male were scanned on 192-slice CT scanner at eleven different vertical positions (maximal off-centering ± 5 cm). Monte Carlo simulations were performed for each of the investigated setup, using tube current values extracted from the raw data, in order to obtain 3D dose distributions...
August 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28817147/supramolecular-core-glycoshell-polythiophene-nanodots-for-targeted-imaging-and-photodynamic-therapy
#10
Hai-Hao Han, Chang-Zheng Wang, Yi Zang, Jia Li, Tony D James, Xiao-Peng He
Supramolecular self-assembly between poly(3-hexylthiophene-2,5-diyl) (P3HT), a polymeric material extensively used for optoelectronic devices, and fluorescent glycoprobes produces core-glycoshell theranostic nanodots (glyco-dots) capable of targeted imaging and photodynamic therapy of liver and triple-negative breast cancer cells.
August 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28816961/estimating-of-hepatic-fat-amount-using-mri-proton-density-fat-fraction-in-a-real-practice-setting
#11
Hyeyoung Lee, Dae Won Jun, Bo-Kyeong Kang, Eunwoo Nam, Misoo Chang, Mimi Kim, Soonyoung Song, Byung Chul Yoon, Hang Lak Lee, Oh Young Lee, Ho Soon Choi, Kang Nyeong Lee
The recently developed magnetic resonance imaging (MRI) proton density fat fraction (PDFF) allows measurement of the fat in all segments of hepatic tissue. However, it is time consuming and inconvenient to measure each segment repeatedly. Moreover, volume of each segment also should be adjusted with arithmetic mean of the selected segments when total amount of liver fat is estimated. Therefore, we try to develop a clinically-relevant and applicable method of estimating hepatic fat in PDFF image.A total of 164 adults were enrolled...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816798/solid-liver-lesions-in-an-infant-with-neonatal-cholestasis-is-it-always-malignant
#12
Zeren Bariş, Pelin Börcek, Kemal Murat Haberal, Figen Özçay
In this report we describe a patient with neonatal cholestasis who was found to have a liver lesion with suspicious imaging features, although ultimately it was histologically proved to be a pseudotumor. We discuss the characteristic features and imaging findings of macroregenerative nodules of the liver.
August 14, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28816151/quantification-of-pediatric-abdominal-organ-motion-with-a-4-dimensional-magnetic-resonance-imaging-method
#13
Jinsoo Uh, Matthew J Krasin, Yimei Li, Xingyu Li, Christopher Tinkle, John T Lucas, Thomas E Merchant, Chiaho Hua
PURPOSE: To characterize respiration-induced abdominal organ motion in children receiving radiation treatment with a 4-dimensional (4D) magnetic resonance imaging (MRI) method. METHODS AND MATERIALS: We analyzed free-breathing coronal 4D MRI datasets acquired from 35 patients (aged 1-20 years) with abdominal tumors. A deformable image registration of the 4D MRI datasets was performed to derive motion trajectories of selected anatomic landmarks, from which organ motions were quantified...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28816015/liver-transplantation-in-adult-cystic-fibrosis-clinical-imaging-and-pathological-evidence-of-obliterative-portal-venopathy
#14
Sophie Hillaire, Dominique Cazals-Hatem, Onorina Bruno, Sandra De Miranda, Dominique Grenet, Nicolas Poté, Olivier Soubrane, Serge Erlinger, Florence Lacaille, Francois Mellot, Valerie Vilgrain, Valerie Paradis
No abstract text is available yet for this article.
August 16, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28815906/deep-gray-matter-iron-measurement-in-patients-with-liver-cirrhosis-using-quantitative-susceptibility-mapping-relationship-with-pallidal-t1-hyperintensity
#15
Song Lee, Yoonho Nam, Jinhee Jang, Gun Hyung Na, Dong Goo Kim, Na-Young Shin, Hyun Seok Choi, So-Lyung Jung, Kook-Jin Ahn, Bum-Soo Kim
BACKGROUND: The liver is a central organ for the metabolism of iron and manganese and the places where those metals are commonly deposited overlap in the brain. PURPOSE/HYPOTHESIS: To elucidate the relationship between pallidal T1 hyperintensity and iron deposition in the deep gray matter of liver cirrhosis patients using quantitative susceptibility mapping (QSM). STUDY TYPE: Retrospective case-control study SUBJECTS: In all, 38 consecutive liver cirrhosis patients who received brain magnetic resonance imaging (MRI) as pretransplant evaluation...
August 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28815667/diagnostic-performance-of-unenhanced-computed-tomography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-indeterminate-adrenal-tumors
#16
Danae A Delivanis, Irina Bancos, Thomas D Atwell, Grant D Schmit, Patrick W Eiken, Neena Natt, Dana Erickson, Spyridoula Maraka, William F Young, Mark A Nathan
OBJECTIVE: Evidence on the diagnostic performance of adrenal imaging is limited. We aimed to assess the diagnostic performance of unenhanced computed tomography (CT) and(18) F-fluorodeoxyglucose((18) FDG) positron emission tomography(PET)/CT imaging in a high risk population for adrenal malignancy using an optimal reference standard. DESIGN: Retrospective cohort study. METHODS: Imaging studies of patients with adrenal nodules who underwent adrenal biopsy and/or adrenalectomy between 1994 and 2014 were reviewed and compared to the reference standard of histology...
August 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28815645/lenalidomide-as-second-line-therapy-for-advanced-hepatocellular-carcinoma-exploration-of-biomarkers-for-treatment-efficacy
#17
Y-Y Shao, B-B Chen, D-L Ou, Z-Z Lin, C-H Hsu, M-J Wang, A-L Cheng, C Hsu
BACKGROUND: Lenalidomide has immunomodulatory and anti-angiogenic effects and showed moderate anti-tumour efficacy in patients with. advanced hepatocellular carcinoma (HCC) AIM: To explore potential biomarkers of lenalidomide efficacy as second-line therapy for HCC. METHODS: Eligible patients were diagnosed with advanced HCC, documented progression on sorafenib, and Child-Pugh class A liver function. Patients received 25 mg/day lenalidomide orally on days 1-21 every 4 weeks...
August 17, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28815414/comparison-of-image-quality-between-step-and-shoot-and-continuous-bed-motion-techniques-in-whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-with-the-same-acquisition-duration
#18
Shozo Yamashita, Haruki Yamamoto, Tetsu Nakaichi, Tatsuya Yoneyama, Kunihiko Yokoyama
OBJECTIVE: This study aimed to compare the qualities of whole-body positron emission tomography (PET) images acquired by the step-and-shoot (SS) and continuous bed motion (CBM) techniques with approximately the same acquisition duration, through phantom and clinical studies. METHODS: A body phantom with 10-37 mm spheres was filled with (18)F-fluorodeoxyglucose (FDG) solution at a sphere-to-background radioactivity ratio of 4:1 and acquired by both techniques. Reconstructed images were evaluated by visual assessment, percentages of contrast (%Q H) and background variability (%N) in accordance with the Japanese guideline for oncology FDG-PET/computed tomography (CT)...
August 16, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28815349/tumor-volume-doubling-time-as-a-dynamic-prognostic-marker-for-patients-with-hepatocellular-carcinoma
#19
Jong Kwan Kim, Hyung-Don Kim, Mi-Jung Jun, Sung-Cheol Yun, Ju Hyun Shim, Han Chu Lee, Danbi Lee, Jihyun An, Young-Suk Lim, Young-Hwa Chung, Yung Sang Lee, Kang Mo Kim
BACKGROUND AND AIMS: To evaluate the clinical value of tumor growth rate in hepatocellular carcinoma (HCC) patients, we investigated the growth rate of HCC by calculating the tumor volume doubling time (TVDT) and its impact on survival and recurrence. METHODS: A retrospective cohort study of 269 HCC patients who underwent two or more pretreatment imaging studies of computed tomography or magnetic resonance imaging was performed. Tumor growth rate and TVDT were calculated by comparing tumor volumes between imaging studies...
August 16, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28815337/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-as-an-objective-substitute-for-ct-morphologic-response-criteria-in-patients-undergoing-chemotherapy-for-colorectal-liver-metastases
#20
Yujiro Nishioka, Ryuji Yoshioka, Wataru Gonoi, Toshitaka Sugawara, Shuntaro Yoshida, Masaji Hashimoto, Junichi Shindoh
PURPOSE: The computed tomography (CT) morphologic response of colorectal liver metastases (CLM) after chemotherapy is reportedly correlated with pathologic response and survival outcomes of patients undergoing surgery. However, they are rather subjective criteria and not evaluable without adequate quality of contrast-enhanced CT images. This study sought the potential use of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) as an objective substitute for predicting pathological viability of CLM after chemotherapy...
August 16, 2017: Abdominal Radiology
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