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Liver imaging

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https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#1
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29453737/two-stage-hepatectomy-aiming-for-the-development-of-intrahepatic-venous-collaterals-for-multiple-colorectal-liver-metastases
#2
Harufumi Maki, Shouichi Satou, Kentaro Nakajima, Atsuki Nagao, Kazuteru Watanabe, Hitoshi Satodate, Satoshi Nara, Kaoru Furushima, Yasushi Harihara
BACKGROUND: Aggressive hepatectomy with venous resection has a higher risk of postoperative liver failure (POLF) than hepatectomy without venous reconstruction; however, venous reconstruction is technically demanding. We performed a novel two-stage hepatectomy (TSH) without venous reconstruction in a patient with bilobar multiple colorectal liver metastases located near the caval confluence, waiting for the development of intrahepatic venous collaterals between procedures. CASE PRESENTATION: A 60-year-old man was referred to our hospital with sigmoid colon cancer accompanied by intraabdominal abscess and two synchronous liver metastases...
February 16, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29453681/-18-f-fpybf-2-a-new-f-18-labelled-amyloid-imaging-pet-tracer-biodistribution-and-radiation-dosimetry-assessment-of-first-in-man-18-f-fpybf-2-pet-imaging
#3
Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Chio Okuyama, Yoshihiko Kishibe, Masaaki Takahashi, Tomoko Okina, Norio Suzuki, Hiroshi Hasegawa, Yasuhiro Nagahama, Koichi Ishizu, Naoya Oishi, Hiroyuki Kimura, Hiroyuki Watanabe, Masahiro Ono, Hideo Saji, Hiroshi Yamauchi
OBJECTIVE: Recently, a benzofuran derivative for the imaging of β-amyloid plaques, 5-(5-(2-(2-(2- 18 F-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)- N-methylpyridin-2-amine ( 18 F-FPYBF-2) has been validated as a tracer for amyloid imaging and it was found that 18 F-FPYBF-2 PET/CT is a useful and reliable diagnostic tool for the evaluation of AD (Higashi et al. Ann Nucl Med, https://doi.org/10.1007/s12149-018-1236-1 , 2018). The aim of this study was to assess the biodistribution and radiation dosimetry of diagnostic dosages of 18 F-FPYBF-2 in normal healthy volunteers as a first-in-man study...
February 16, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29452852/reduction-of-patient-radiation-dose-with-a-new-organ-based-dose-modulation-technique-for-thoraco-abdominopelvic-computed-tomography-ct-liver-dose-right-index
#4
M Fillon, S Si-Mohamed, P Coulon, A Vuillod, P Klahr, L Boussel
PURPOSE: To evaluate the radiation dose reduction, image quality and diagnostic confidence with thoraco-abdominopelvic computed tomography (TACT) using a new organ based dose modulation system (liver dose right index [Liver DRI]), compared to TACT using a standard automatic exposure control adjusting mA according to attenuation. METHODS: A total of 37 patients who had two TACT examinations on 2 different CT scanners, one using standard automatic exposure control (combination of a DoseRight automatic current selection and Z modulation) and one using Liver DRI were included...
February 13, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29452205/impaired-cerebral-microcirculation-induced-by-ammonium-chloride-in-rats-is-due-to-cortical-adenosine-release
#5
Peter Nissen Bjerring, Esben Jannik Bjerrum, Fin Stolze Larsen
BACKGROUND: Liver failure results in hyperammonaemia, impaired regulation of cerebral microcirculation, encephalopathy and death. However, the key mediator that alters cerebral microcirculation remains unidentified. In this study we show that topical ammonium significantly increases periarteriolar adenosine tone on the brain surface of healthy rats and is associated with a disturbed microcirculation. METHODS: Cranial windows were prepared in anaesthetized Wistar rats...
February 13, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29451329/high-spatiotemporal-resolution-bssfp-imaging-of-hyperpolarized-1-13-c-pyruvate-and-1-13-c-lactate-with-spectral-suppression-of-alanine-and-pyruvate-hydrate
#6
Eugene Milshteyn, Cornelius von Morze, Jeremy W Gordon, Zihan Zhu, Peder E Z Larson, Daniel B Vigneron
PURPOSE: The balanced steady-state free precession (bSSFP) acquisition enables high spatiotemporal resolution for hyperpolarized 13 C MRI at 3T but is limited by spectral contamination from adjacent resonances. The purpose of this study was to develop a framework for in vivo dynamic high resolution imaging of hyperpolarized [1- 13 C]pyruvate and [1- 13 C]lactate generated in vivo at 3T by simplifying the spectrum through the use of selective suppression pulses. METHODS: Spectral suppression pulses were incorporated into the bSSFP sequence for suppression of [1- 13 C]alanine and [1- 13 C]pyruvate-hydrate signals, leaving only the pyruvate and lactate resonances...
February 16, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29451124/copper-oxide-loaded-plga-nanospheres-towards-a-multifunctional-nanoscale-platform-for-ultrasound-based-imaging-and-therapy
#7
Or Perlman, Iris S Weitz, Sarit Sivan, Hiba Abu-Khalla, Madeleine Benguigui, Yuval Shaked, Haim Azhari
Copper oxide nanoparticles (CuO-NPs) are increasingly investigated for diagnostic and therapeutic purposes. Recent work have demonstrated their anticancer potential as well as contrast agent capabilities for magnetic resonance imaging (MRI) and through-transmission ultrasound. However, no capabilities of CuO-NPS were demonstrated using conventional ultrasound systems, which, unlike the formers, are widely deployed in the clinic. Furthermore, in spite of their potential as multifunctional nano-based materials for diagnosis and therapy, CuO-NPs were delayed from further clinical translation due to their inherent toxicity...
February 16, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29450611/high-spatial-resolution-navigated-3d-t1-weighted-hepatobiliary-mr-cholangiography-using-gd-eob-dtpa-for-evaluation-of-biliary-anatomy-in-living-liver-donors
#8
Jei Hee Lee, Bohyun Kim, Hye Jin Kim, Bong-Wan Kim, Hee-Jung Wang, Jai Keun Kim
PURPOSE: To determine the feasibility of high-resolution navigated three-dimensional (3D) T1-weighted hepatobiliary MR cholangiography (Nav T1 MRC) using Gd-EOB-DTPA for biliary visualization in living liver donors and to assess added value of 3D T1-weighted hepatobiliary MRCs in improving the confidence and diagnostic accuracy of biliary anatomy in complementary to T2-weighted MRCs. METHODS: Twenty-nine right liver donors underwent 3D T2 MRC, 2D T2 MRC, breath-hold T1-weighted hepatobiliary MRC (BH T1 MRC), and Nav T1 MRC...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29450605/abbreviated-mpmri-protocol-for-diffuse-liver-disease-a-practical-approach-for-evaluation-and-follow-up-of-nafld
#9
Guilherme Moura Cunha, Cristiane A Villela-Nogueira, Anke Bergman, Flavia Paiva Proença Lobo Lopes
AIM: Multiparametric magnetic resonance imaging (mpMRI) may help determine the metabolic profile of patients with obesity and metabolic syndrome in addition to their clinical and laboratory biomarkers for diagnosis and monitoring. An abbreviated mpMRI protocol may be a faster, less-costly, and easier to perform alternative for the diagnosis, treatment, and follow-up of patients with NAFLD and for use in clinical trials. OBJECTIVE: To evaluate an abbreviated mpMRI protocol tailored to analyze quantitative imaging features of patients with obesity and NAFLD and assess its use during treatment...
February 15, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29449266/fungal-liver-abscess-in-an-immunocompetent-patient-who-underwent-repeated-ercps-and-subtotal-cholecystectomy
#10
Sundas Hasan, Robert Fearn
We report a case of a previously healthy female patient who initially presented with fever, jaundice and right upper quadrant pain three days after dilatation and stenting of a stricture of the common bile duct (CBD). During an earlier admission, the patient had undergone endoscopic retrograde cholangiopancreatography (ERCP) having presented with fevers and biliary dilatation on ultrasound. The ERCP features were more consistent with Mirizzi's Syndrome. The patient subsequently underwent subtotal cholecystectomy and later developed a CBD stricture, requiring repeat ERCP and stent insertion...
February 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29448290/characterization-of-severe-arterial-phase-respiratory-motion-artifact-on-gadoxetate-disodium-enhanced-mri-assessment-of-interrater-agreement-and-reliability
#11
Kristina Imeen Ringe, Julian A Luetkens, Rolf Fimmers, Renate Maria Hammerstingl, Günter Layer, Martin H Maurer, Claas Philip Nähle, Sabine Michalik, Peter Reimer, Christina Schraml, Andreas G Schreyer, Patrick Stumpp, Thomas J Vogl, Frank K Wacker, Winfried Willinek, Guido Mattias Kukuk
PURPOSE: To assess the interrater agreement and reliability of experienced abdominal radiologists in the characterization and grading of arterial phase gadoxetate disodium-related respiratory motion artifact on liver MRI. MATERIALS AND METHODS: This prospective multicenter study was initiated by the working group for abdominal imaging within the German Roentgen Society (DRG), and approved by the local IRB of each participating center. 11 board-certified radiologists independently reviewed 40 gadoxetate disodium-enhanced liver MRI datasets...
February 15, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29448119/estimation-of-hepatic-fat-fraction-using-modified-dixon-magnetic-resonance-imaging-techniques-effect-of-liver-cirrhosis
#12
Jeeyoung Min, Hee Sun Park, Young Jun Kim, Mi Hye Yu, Sung Il Jung, Hae Jeong Jeon
PURPOSE: To evaluate modified Dixon MRI techniques in hepatic fat estimation and to assess the effect of cirrhosis. METHODS: 235 patients who underwent liver MRI were included. Correlation between modified Dixon techniques with MRS was assessed. Accuracy of MR techniques in hepatic fat estimation was calculated, and the result was compared between patients with/without liver cirrhosis. RESULTS: Correlation between modified Dixon and MRS was better in group without liver cirrhosis, and accuracy of modified Dixon method was higher in group without liver cirrhosis...
February 7, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29447203/quantification-of-fetal-organ-volume-and-fat-deposition-following-in-utero-exposure-to-maternal-western-diet-using-mri
#13
Kevin J Sinclair, Lanette J Friesen-Waldner, Colin M McCurdy, Curtis N Wiens, Trevor P Wade, Barbra de Vrijer, Timothy R H Regnault, Charles A McKenzie
PURPOSE: To examine the feasibility of using MRI to identify differences in liver size and fat deposition in fetal guinea pigs exposed to an in utero environment influenced by maternal consumption of a Western diet. MATERIALS AND METHODS: Female guinea pigs fed either an energy-dense Western Diet (WD), comprised of increased saturated fats and simple sugars, or a Control Diet (CD) from weaning through pregnancy, underwent MR scanning near term (~ 60 days; term ~ 69 days)...
2018: PloS One
https://www.readbyqxmd.com/read/29446627/ultrabright-and-fluorogenic-probes-for-multicolor-imaging-and-tracking-of-lipid-droplets-in-cells-and-tissues
#14
Mayeul Collot, Tkhe-Kyong Fam, Pichandi Ashokkumar, Orestis Faklaris, Thierry Galli, Lydia Danglot, Andrey S Klymchenko
Lipid droplets (LDs) are intracellular lipid-rich organelles that regulate the storage of neutral lipids and were recently found to be involved in many physiological processes, metabolic disorders as well as diseases including obesity, diabetes and cancers. Herein we present a family of new fluorogenic merocyanine fluorophores based on an indolenine moiety and a dioxaborine barbiturate derivative. These so-called StatoMerocyanines (SMCy) span their fluorescence from yellow to the near infrared (NIR) in oil with an impressive fluorescence enhancement compared to aqueous media...
February 15, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29446508/accelerated-t-2-mapping-combining-parallel-mri-and-model-based-reconstruction-grappatini
#15
Tom Hilbert, Tilman J Sumpf, Elisabeth Weiland, Jens Frahm, Jean-Philippe Thiran, Reto Meuli, Tobias Kober, Gunnar Krueger
BACKGROUND: Quantitative T 2 measurements are sensitive to intra- and extracellular water accumulation and myelin loss. Therefore, quantitative T 2 promises to be a good biomarker of disease. However, T 2 measurements require long acquisition times. PURPOSE: To accelerate T 2 quantification and subsequent generation of synthetic T 2 -weighted (T 2 -w) image contrast for clinical research and routine. To that end, a recently developed model-based approach for rapid T 2 and M 0 quantification (MARTINI) based on undersampling k-space, was extended by parallel imaging (GRAPPA) to enable high-resolution T 2 mapping with access to T 2 -w images in less than 2 minutes acquisition time for the entire brain...
February 15, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29445834/the-combination-of-2-5-dihydroxybenzoic-acid-and-2-5-dihydroxyacetophenone-matrices-for-unequivocal-assignment-of-phosphatidylethanolamine-species-in-complex-mixtures
#16
Jenny Schröter, Annabelle Fülöp, Carsten Hopf, Jürgen Schiller
Unequivocal assignment of phospholipid peaks in complex mixtures is difficult if only the m/z values but no tandem mass spectrometry (MS/MS) data are available. This is usually the case for matrix-assisted laser/desorption ionization time-of-flight (MALDI-TOF) MS imaging experiments and the analysis has normally to be performed without prior separation. Another problem might be the often matrix-induced loss of one methyl group in phosphatidylcholine (PC) species, which makes them detectable as negative ions becoming isomers of some phosphatidylethanolamines (PEs)...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29444709/mucinous-cystic-neoplasm-of-the-liver-with-extrahepatic-growth-presenting-with-ascending-cholangitis-diagnosed-by-endoscopic-ultrasound-features-a-case-report
#17
Tanawat Pattarapuntakul, Bancha Ovartlarnporn, Jaksin Sottisuporn
BACKGROUND: Mucinous cystic neoplasm of the liver with extrahepatic growth is a rare benign epithelial neoplasm of the biliary system that presents with a mass effect or is incidentally found on imaging. The tumor affects mostly the common hepatic duct, which is difficult to diagnose preoperatively by radiology, endoscopy, or cystic fluid analysis. Endoscopic ultrasound is a noninvasive tool for the evaluation of features of a cystic lesion and the extent of disease. Optimal treatment is complete tumor resection...
February 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29444588/periaortic-adipose-tissue-compared-with-peribrachial-adipose-tissue-mass-as-markers-and-possible-modulators-of-cardiometabolic-risk
#18
Elko Randrianarisoa, Norbert Stefan, Andreas Fritsche, Anja Hieronimus, Bernd Balletshofer, Jürgen Machann, Dorothea Siegel-Axel, Hans-Ulrich Häring, Kilian Rittig
Increased perivascular fat mass contributes to cardiometabolic risk (CMR). High peribrachial adipose tissue (PBAT) associates with insulin resistance independently of established CMR parameters. It is unknown to what extent periaortic adipose tissue (PAAT) may have a similar impact. In 95 participants, precise quantification of total adipose tissue, PBAT, PAAT, visceral adipose tissue (VAT), and liver fat (LF) content was performed by whole-body magnetic resonance imaging. Insulin sensitivity was determined by oral glucose tolerance test and carotid intima-media thickness (cIMT) by high-resolution ultrasound...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29444164/evolution-of-nodule-stiffness-might-predict-response-to-local-ablative-therapy-a-series-of-patients-with-hepatocellular-carcinoma
#19
Michael Praktiknjo, Viktoria Krabbe, Alessandra Pohlmann, Matthias Sampels, Christian Jansen, Carsten Meyer, Christian P Strassburg, Jonel Trebicka, Maria A Gonzalez Carmona
BACKGROUND: Early information on treatment response of HCC to local ablative therapy is crucial. Elastography as a non-invasive method has recently been shown to play a potential role in distinguishing between benign and malignant liver lesions. Elastography of hepatocellular carcinoma (HCC) in early response to local ablative therapy has not been studied to date. METHODS: We prospectively included a cohort of 14 patients with diagnosis of HCC who were treated with local ablative therapy (transarterial chemoembolization, TACE and/or radiofrequency ablation, RFA)...
2018: PloS One
https://www.readbyqxmd.com/read/29444146/prediction-of-small-for-size-syndrome-after-extended-hepatectomy-tissue-characterization-by-relaxometry-diffusion-weighted-magnetic-resonance-imaging-and-magnetization-transfer
#20
Christian Eberhardt, Moritz C Wurnig, Andrea Wirsching, Cristina Rossi, Idana Feldmane, Mickael Lesurtel, Andreas Boss
This study aimed to monitor the course of liver regeneration by multiparametric magnetic-resonance imaging (MRI) after partial liver resection characterizing Small-for-Size Syndrome (SFSS), which frequently leads to fatal post-hepatectomy liver failure (PLF). Twenty-two C57BL/6 mice underwent either conventional 70% partial hepatectomy (cPH), extended 86% partial hepatectomy (ePH) or SHAM operation. Subsequent MRI scans on days 0, 1, 2, 3, 5 and 7 in a 4.7T MR Scanner quantified longitudinal and transverse relaxation times, apparent diffusion coefficient (ADC) and the magnetization-transfer ratio (MTR) of the regenerating liver parenchyma...
2018: PloS One
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