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https://www.readbyqxmd.com/read/28343127/direct-immobilization-of-manganese-chelates-on-silica-nanospheres-for-mri-applications
#1
Marcell Pálmai, Adrienn Pethő, Lívia Naszályi Nagy, Szilvia Klébert, Zoltán May, Judith Mihály, András Wacha, Katalin Jemnitz, Zsuzsanna Veres, Ildikó Horváth, Krisztián Szigeti, Domokos Máthé, Zoltán Varga
The development of tissue specific magnetic resonance imaging (MRI) contrast agents (CAs) is very desirable to achieve high contrast ratio combined with excellent anatomical details. To this end, we introduce a highly effective manganese(II) containing silica material, with the aim to shorten the longitudinal (T1) relaxation time. The microporous silica nanospheres (MSNSs) with enlarged porosity and specific surface area were prepared by a surfactant assisted aqueous method. Subsequently, the surface silanol groups were amino-functionalized, reacted with diethylenetriaminepentaacetic (DTPA) dianhydride and finally deposited with Mn(2+)...
March 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28342361/giant-leiomyosarcoma-of-the-rectum-with-lymph-node-metastasis-a-case-report-and-review-of-the-literature
#2
Hiroyuki Anzai, Hiroaki Nozawa, Junichiro Tanaka, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Keisuke Hata, Kazushige Kawai, Tetsuo Ushiku, Soichiro Ishihara, Toshimi Takano, Masashi Fukayama, Toshiaki Watanabe
INTRODUCTION: Leiomyosarcoma of the gastrointestinal tract is very rare, with a reported frequency of less than 0.1% of all malignancies of the colorectum. It is important to diagnose leiomyosarcoma definitively by immunohistochemical profiling of smooth muscle actin, desmin, and CD34. True leiomyosarcoma of the colorectum diagnosed by immunnohistochemical profiling is extremely rare that only 13 reports have been published in reviews of resected gastrointestinal mesenchymal tumors after 1998...
March 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28340131/interobserver-variability-in-histologic-evaluation-of-liver-fibrosis-using-categorical-and-quantitative-scores
#3
Michael Pavlides, Jacqueline Birks, Eve Fryer, David Delaney, Nikita Sarania, Rajarshi Banerjee, Stefan Neubauer, Eleanor Barnes, Kenneth A Fleming, Lai Mun Wang
Objectives: The aim of the study was to investigate the interobserver agreement for categorical and quantitative scores of liver fibrosis. Methods: Sixty-five consecutive biopsy specimens from patients with mixed liver disease etiologies were assessed by three pathologists using the Ishak and nonalcoholic steatohepatitis Clinical Research Network (NASH CRN) scoring systems, and the fibrosis area (collagen proportionate area [CPA]) was estimated by visual inspection (visual-CPA)...
March 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339312/biomacromolecule-lipid-hybrid-nanoparticles-for-controlled-delivery-of-sorafenib-in-targeting-hepatocellular-carcinoma-therapy
#4
Jing Zhang, Tianqi Wang, Shengjun Mu, Livesey D Olerile, Xiaoyue Yu, Na Zhang
AIM: Hybrids composed of various materials are highly versatile for drug delivery in tumor therapy including hepatocellular carcinoma. Herein, a sorafenib (SF)-loaded biomacromolecule hyaluronic acid (HA)/lipid hybrid nanoparticles (HA/SF-cLNS) were developed for targeting drug delivery. MATERIALS & METHODS: In vitro assays determined HA/SF-cLNS release behavior, enzymatic degradation, uptake and cytotoxicity. H22-bearing liver cancer xenograft murine models were used to evaluate the biodistribution and therapeutic efficacy in vivo...
March 24, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28338529/dosimetry-software-hermes-internal-radiation-dosimetry-from-quantitative-image-reconstruction-to-voxel-level-absorbed-dose-distribution
#5
Eero T Hippeläinen, Mikko J Tenhunen, Hanna O Mäenpää, Jorma J Heikkonen, Antti O Sohlberg
OBJECTIVE: The aim of this work is to validate a software package called Hermes Internal Radiation Dosimetry (HIRD) for internal dose assessment tailored for clinical practice. The software includes all the necessary steps to perform voxel-level absorbed dose calculations including quantitative reconstruction, image coregistration and volume of interest tools. METHODS: The basics of voxel-level dosimetry methods and implementations to HIRD software are reviewed...
March 23, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28338471/generalized-psf-modelling-for-optimized-quantitation-in-pet-imaging
#6
Saeed Ashrafinia, Hassan Mohy-Ud-Din, Nicolas Karakatsanis, Abhinav Jha, Michael Casey, Dan Kadrmas, Arman Rahmim
Point-Spread Function (PSF) modelling offers the capability to account for resolution degrading phenomena within the PET reconstruction framework. PSF modelling improves resolution and enhances contrast, but at the same time significantly alters image noise properties and induces edge overshoot effect. Thus, studying the effect of PSF modelling on quantitation task performance can be very important. Frameworks explored in the past involve a dichotomy of PSF vs. no-PSF modelling. By contrast, the present work focuses on quantitative performance evaluation of standard uptake value (SUV) PET images, while incorporating a wide spectrum of PSF models, including those that under- and over-estimate the true PSF, for the potential of enhanced quantitation of standardized uptake values (SUVs)...
March 24, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28338167/-comparison-of-ct-manifestations-of-primary-colorectal-mucinous-adenocarcinoma-and-signet-ring-cell-carcinoma
#7
Zhenhui Li, Zhiping Zhang, Xingxiang Dong, Depei Gao, Dafu Zhang
OBJECTIVE: To compare the difference in CT manifestations between primary colorectal mucinous adenocarcinoma and signet ring cell carcinoma in order to improve radiologic diagnosis. METHODS: Clinicopathological data and CT findings of 109 patients with colorectal mucinous adenocarcinoma and 46 patients with primary colorectal signet-ring cell carcinoma confirmed by surgery and pathology from March 2008 to February 2015 in the Tumor Hospital of Yunnan Province were retrospectively collected...
March 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28337285/preclinical-and-clinical-evaluation-of-the-liver-tumor-irreversible-electroporation-by-magnetic-resonance-imaging
#8
Matteo Figini, Xifu Wang, Tianchu Lyu, Zhanliang Su, Daniele Procissi, Vahid Yaghmai, Andrew C Larson, Zhuoli Zhang
Irreversible electroporation (IRE) is a relatively new technique for tumor ablation. It has shown promising results in difficult cases where surgery is not recommended and delicate anatomic structures are present near or within the tumor. Currently, liver cancer is one of the most common targets for IRE treatment. Pre-operative and post-operative imaging has a key role in IRE procedures and research studies. Although ultrasound is usually the first choice, especially for intra-operative guidance, magnetic resonance imaging (MRI) plays an important role in the visualization and characterization of tumor before and after IRE in clinical and preclinical studies...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28336780/biodistribution-and-radiation-dosimetry-for-the-tau-tracer-18-f-thk-5351-in-healthy-human-subjects
#9
Ing-Tsung Hsiao, Kun-Ju Lin, Kuo-Lun Huang, Chin-Chang Huang, Han-Shiuan Chen, Shiaw-Pyng Wey, Tzu-Chen Yen, Nobuyuki Okamura, Jung-Lung Hsu
(18)F-THK-5351 is a novel radiotracer that demonstrates high binding selectivity and affinity for tau pathology and exhibits better pharmacokinetics in the living brain than previous THK tau probes. The aim of the present study was to estimate the radiation dose of (18)F-THK-5351 in humans and to compare the clinical radiation dosimetry results to estimations published previously with preclinical data. Methods: Serial whole-body positron emission tomography/computed tomography (PET/CT) imaging was performed for 240 min on 12 healthy volunteers after injecting (18)F-THK-5351 (mean administered activity: 377...
March 23, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28335859/making-it-new-again-insight-into-liver-development-regeneration-and-disease-from-zebrafish-research
#10
Shuang Wang, Sophie R Miller, Elke A Ober, Kirsten C Sadler
The adult liver of most vertebrates is predominantly comprised of hepatocytes. However, these cells must work in concert with biliary, stellate, vascular, and immune cells to accomplish the vast array of hepatic functions required for physiological homeostasis. Our understanding of liver development was accelerated as zebrafish emerged as an ideal vertebrate system to study embryogenesis. Through work in zebrafish and other models, it is now clear that the cells in the liver develop in a coordinated fashion during embryogenesis through a complex yet incompletely understood set of molecular guidelines...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28335794/tumor-motion-changes-in-stereotactic-body-radiotherapy-for-liver-tumors-an-evaluation-based-on-four-dimensional-cone-beam-computed-tomography-and-fiducial-markers
#11
Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya, Fujio Araki
BACKGROUND: For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning simulation represents liver tumor motion during SBRT, and estimated inter- and intrafractional tumor motion changes in patients undergoing liver SBRT. METHODS: Ten patients underwent four-dimensional cone-beam computed tomography (4D-CBCT) image-guided liver SBRT with abdominal compression (AC) and fiducial markers...
March 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28334490/mr-cholangiography-in-potential-liver-donors-quantitative-and-qualitative-improvement-with-administration-of-an-oral-effervescent-agent
#12
Heon-Ju Kwon, Kyoung Won Kim, Sang Hyun Choi, Jin-Hee Jung, So Yeon Kim, Se-Young Kim, Jeongjin Lee, Dong-Hwan Jung, Tae-Yong Ha, Gi-Won Song, Sung-Gyu Lee
PURPOSE: To determine whether an oral effervescent agent improves magnetic resonance cholangiography (MRC) images, both qualitatively and quantitatively, in potential live liver donors. MATERIALS AND METHODS: This retrospective study was approved by the Institutional Review Board, and informed consent was waived. Seventy potential liver donors underwent 2D MRC before and after administration of an oral effervescent agent. One radiologist measured relative contrast ratio (rC) and relative signal intensity (rS) for right and left intrahepatic ducts (RHD and LHD), and common hepatic duct (CHD)...
March 23, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28333768/management-of-pediatric-non-alcoholic-fatty-liver-disease-by-academic-hepatologists-in-canada-a-nationwide-survey
#13
Marialena Mouzaki, Simon C Ling, Richard A Schreiber, Binita M Kamath
BACKGROUND: The literature on the optimal clinical management of pediatric patients with non-alcoholic fatty liver disease (NAFLD) is limited. The objective of this study was to identify discrepancies in the care provided to patients with NAFLD by hepatologists practicing in academic centers across Canada. METHODS: A nationwide survey was distributed electronically to all pediatric hepatologists practicing in university-affiliated hospitals using the infrastructure of the Canadian Pediatric Hepatology Research Group...
March 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28333715/noninvasive-imaging-of-stored-red-blood-cell-transfusion-aggravating-sepsis-induced-liver-injury-associated-with-increased-activation-of-m1-polarized-kupffer-cells
#14
Tao Wu, Lei Wang, Jie An, Chao Y Wu, Yue Wang, Lu Qian, Jun Zhou, Yu L Zhang, Qian Q Zhou, Xiao H Wang, Hua F Wang, Qiu X Fu, Lin S Zhan
Liver injury has a critical effect on the severity and outcome of sepsis. The impact of stored RBCs on the pathogenesis of sepsis-associated hepatic injury is not well understood. Therefore, to investigate the effects of stored-RBC transfusion on sepsis-induced liver damage as well as the associated mechanism, we constructed a sepsis mouse model enabling non-invasive imaging of bacterial infection caused by Pseudomonas aeruginosa, a common gram-negative respiratory pathogen. We showed that transfusions with stored RBCs enhanced sepsis-induced liver injury in vivo, and liver injury exacerbated the severity of sepsis and decreased survival in P...
March 22, 2017: Shock
https://www.readbyqxmd.com/read/28333690/diagnosis-and-evaluation-of-hyperbilirubinemia
#15
Jeremy I Sullivan, Don C Rockey
PURPOSE OF REVIEW: Jaundice, the physical finding associated with hyperbilirubinemia, results when the liver is unable to properly metabolize or excrete bilirubin. The purpose of this review is to examine some of the most common causes of jaundice in adults, provide insight into the diagnostic evaluation of jaundice, and review information on the outcomes of patients with jaundice. RECENT FINDINGS: An elevated level of bilirubin almost always indicates the presence of an underlying disease state...
March 22, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28332992/clinical-implementation-of-a-model-based-in%C3%A2-vivo-dose-verification-system-for-stereotactic-body-radiation-therapy-volumetric-modulated-arc-therapy-treatments-using-the-electronic-portal-imaging-device
#16
Peter M McCowan, Ganiyu Asuni, Eric Van Uytven, Timothy VanBeek, Boyd M C McCurdy, Shaun K Loewen, Naseer Ahmed, Bashir Bashir, James B Butler, Amitava Chowdhury, Arbind Dubey, Ahmet Leylek, Maged Nashed
PURPOSE: To report findings from an in vivo dosimetry program implemented for all stereotactic body radiation therapy patients over a 31-month period and discuss the value and challenges of utilizing in vivo electronic portal imaging device (EPID) dosimetry clinically. METHODS AND MATERIALS: From December 2013 to July 2016, 117 stereotactic body radiation therapy-volumetric modulated arc therapy patients (100 lung, 15 spine, and 2 liver) underwent 602 EPID-based in vivo dose verification events...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332211/a-multi-channel-block-matching-denoising-algorithm-for-spectral-photon-counting-ct-images
#17
Adam P Harrison, Ziyue Xu, David A Bluemke, Amir Pourmorteza, Daniel J Mollura
PURPOSE: We present a denoising algorithm designed for a whole-body prototype photon-counting computed tomography (PCCT) scanner with up to 4 energy thresholds and associated energy-binned images. METHODS: Spectral PCCT images can exhibit low signal to noise ratios (SNRs) due to the limited photon counts in each simultaneously-acquired energy bin. To help address this, our denoising method exploits the correlation and exact alignment between energy bins, adapting the highly-effective block-matching 3D (BM3D) denoising algorithm for PCCT...
March 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28332160/robust-motion-tracking-in-liver-from-2d-ultrasound-images-using-supporters
#18
Ece Ozkan, Christine Tanner, Matej Kastelic, Oliver Mattausch, Maxim Makhinya, Orcun Goksel
PURPOSE: Effectiveness of image-guided radiation therapy with precise dose delivery depends highly on accurate target localization, which may involve motion during treatment due to, e.g., breathing and drift. Therefore, it is important to track the motion and adjust the radiation delivery accordingly. Tracking generally requires reliable target appearance and image features, whereas in ultrasound imaging acoustic shadowing and other artifacts may degrade the visibility of a target, leading to substantial tracking errors...
March 22, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28331176/novel-microwave-torso-scanner-for-thoracic-fluid-accumulation-diagnosis-and-monitoring
#19
S Ahdi Rezaeieh, A Zamani, K S Bialkowski, A M Abbosh
Thoracic fluid accumulation is one of the significant and early-stage manifestations of fatal diseases, such as lung-cancer, liver-failure and congestive heart-failure. Currently, computational-tomography (CT)-Scan is the most widely used tool for the detection of thoracic fluid. Yet, it is unable to detect small amounts of fluid, has ionizing radiation and lacks mobility. On the other hand, microwave imaging systems have emerged as an accurate and portable complementary diagnostic tool. However, there is a lack of a complete clinical platform that can fulfill the requirements of accurate and reliable imaging...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330662/pericardial-but-not-hepatic-fat-by-ct-is-associated-with-cv-outcomes-and%C3%A2-structure-the-multi-ethnic-study-of-atherosclerosis
#20
Ravi V Shah, Amanda Anderson, Jingzhong Ding, Matthew Budoff, Oliver Rider, Steffen E Petersen, Majken Karoline Jensen, Manja Koch, Matthew Allison, Nadine Kawel-Boehm, Jessica Wisocky, Michael Jerosch-Herold, Kenneth Mukamal, Joao A C Lima, Venkatesh L Murthy
OBJECTIVES: The study sought to determine the associations between local (pericardial) fat and incident cardiovascular disease (CVD) events and cardiac remodeling independent of markers of overall adiposity. BACKGROUND: The impact of pericardial fat-a local fat depot encasing the heart-on myocardial function and long-term CV prognosis independent of systemic consequences of adiposity or hepatic fat is an area of active debate. METHODS: We studied 4,234 participants enrolled in the MESA (Multi-Ethnic Study of Atherosclerosis) study with concomitant cardiac magnetic resonance imaging and computed tomography (CT) measurements for pericardial fat volume and hepatic attenuation (a measure of liver fat)...
March 10, 2017: JACC. Cardiovascular Imaging
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