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Liver imaging

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https://www.readbyqxmd.com/read/29241024/age-and-gender-associated-liver-physiological-t1rho-dynamics-demonstrated-with-a-clinically-applicable-single-breathhold-acquisition
#1
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony W L Kwok, Eric K W Liu, Weitian Chen
To understand women's and men's physiological ranges of liver T1rho relaxation time measured with a single breathhold black blood sequence, this healthy volunteer study was conducted in 62 women (mean age, 38.9 y; range, 18-75 y) and 34 men (mean age, 44.7 y; range, 24-80 y). Approval from the institutional ethics committee was obtained. Magnetic resonance imaging was performed with a 3.0T scanner with six spin-lock times of 0, 10, 20, 25, 35, and 50 ms and a single breathhold of 12 s per slice acquisition...
December 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/29239710/liver-fibrosis-deep-convolutional-neural-network-for-staging-by-using-gadoxetic-acid-enhanced-hepatobiliary-phase-mr-images
#2
Koichiro Yasaka, Hiroyuki Akai, Akira Kunimatsu, Osamu Abe, Shigeru Kiryu
Purpose To investigate the performance of a deep convolutional neural network (DCNN) model in the staging of liver fibrosis using gadoxetic acid-enhanced hepatobiliary phase magnetic resonance (MR) imaging. Materials and Methods This retrospective study included patients for whom input data (hepatobiliary phase MR images, static magnetic field of the imaging unit, and hepatitis B and C virus testing results available, either positive or negative) and reference standard data (liver fibrosis stage evaluated from biopsy or surgical specimens obtained within 6 months of the MR examinations) were available were assigned to the training (534 patients) or the test (100 patients) group...
December 14, 2017: Radiology
https://www.readbyqxmd.com/read/29238866/validation-of-goose-liver-fat-measurement-by-qct-and-cse-mri-with-biochemical-extraction-and-pathology-as-reference
#3
Li Xu, Yangyang Duanmu, Glen M Blake, Chenxin Zhang, Yong Zhang, Keenan Brown, Xiaoqi Wang, Peng Wang, Xingang Zhou, Manling Zhang, Chao Wang, Zhe Guo, Giuseppe Guglielmi, Xiaoguang Cheng
OBJECTIVES: This study aimed to validate the accuracy and reliability of quantitative computed tomography (QCT) and chemical shift encoded magnetic resonance imaging (CSE-MRI) to assess hepatic steatosis. METHODS: Twenty-two geese with a wide range of hepatic steatosis were collected. After QCT and CSE-MRI examinations, the liver of each goose was removed and samples were taken from the left lobe, upper and lower half of the right lobe for biochemical measurement and histology...
December 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29237901/transarterial-chemoembolization-with-gelatin-sponge-microparticles-for-barcelona-clinic-liver-cancer-stage-c-and-large-hepatocellular-carcinoma-initial-clinical-experience
#4
Jun Zhou, Ying Liu, Zhizhong Ren, Yuewei Zhang, Ming Zhang
OBJECTIVE: The purpose of this investigation is to present a preliminary clinical experience in transarterial chemoembolization (TACE) with gelatin sponge microparticles (GSMs) for barcelona clinic liver cancer (BCLC) Stage C and large hepatocellular carcinoma (HCC) patients in China. MATERIALS AND METHODS: Between August 2009 and August 2012, 20 BCLC Stage C HCC patients with tumor size ≥5 cm undergoing GSMs-TACE were retrospectively analyzed. Tumor response was evaluated using modified response evaluation criteria in solid tumors (mRECIST) with enhanced magnetic resonance/computed tomography imaging performed 4-6 weeks after each GSMs-TACE procedure...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29236342/longitudinal-assessment-of-rabbit-renal-fibrosis-induced-by-unilateral-ureteral-obstruction-using-two-dimensional-susceptibility-weighted-imaging
#5
Jing-Gang Zhang, Zhao-Yu Xing, Ting-Ting Zha, Xiao-Juan Tian, Ya-Nan Du, Jie Chen, Wei Xing
BACKGROUND: Previous studies indicated that two-dimensional-susceptibility weighted imaging (2D-SWI) could serve as a useful biomarker for differentiating the grade of liver fibrosis. PURPOSE: To evaluate the feasibility of 2D-SWI in the dynamic quantification of renal fibrosis in a rabbit model. STUDY TYPE: Longitudinal study. ANIMAL MODEL: Twenty-Four New Zealand White Rabbits including control group (n = 4); and renal fibrosis group (n = 20), by means of a unilateral ureteral obstruction (UUO) model...
December 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#6
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29235879/experimental-studies-on-artifacts-and-tumor-enhancement-on-gadoxetic-acid-enhanced-arterial-phase-liver-mri-in-a-rabbit-vx2-tumor-model
#7
Takahiro Tsuboyama, Gregor Jost, Tonsok Kim, Masatoshi Hori, Hiromitsu Onishi, Hubertus Pietsch, Noriyuki Tomiyama
Background Rapid injection of gadoxetic acid is reported to produce more frequent artifacts and lower vascular enhancement on arterial phase liver magnetic resonance imaging (MRI). However, its effect on tumor enhancement and the mechanism of the artifacts remain unclear. Purpose To evaluate the effect of rapid injection of gadoxetic acid on artifacts and tumor enhancement during arterial phase liver MRI, and on arterial blood gases (ABGs) which may explain the cause of the artifacts. Material and Methods ABG analysis was performed in 13 free-breathing rabbits after rapid injection (1 mL/s; injection time = 0...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29235846/cu-ii-doped-polydopamine-coated-gold-nanorods-for-tumor-theranostics
#8
Shuwei Liu, Lu Wang, Min Lin, Dandan Wang, Ziqi Song, Shuyao Li, Rui Ge, Xue Zhang, Yi Liu, Zhimin Li, Hongchen Sun, Bai Yang, Hao Zhang
Gold nanorods (AuNRs) are potentially useful in tumor theranostics, but the poor stability, high toxicity, and rapid removal by the immune system seriously limit their theranostic applications. In our study, we demonstrate the fabrication of Cu(II)-doped polydopamine-coated AuNR (AuNR@CuPDA), which significantly improves the potentials in tumor theranostics. Besides the improvement of physiological stability and biocompatibility, the PDA shell increases the photothermal performance and prolongs the blood circulation time of AuNRs...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235162/iron-chelating-effect-of-silymarin-in-patients-with-%C3%AE-thalassemia-major-a-crossover-randomised-control-trial
#9
Hadi Darvishi-Khezri, Ebrahim Salehifar, Mehrnoush Kosaryan, Hossein Karami, Mohammadreza Mahdavi, Abbas Alipour, Aily Aliasgharian
This study aimed to determine the potential iron-chelating effects of silymarin in patients with β-thalassemia major receiving standard iron-chelation therapy. We evaluated whether addition of silymarin to standard iron-chelation therapy could improve iron burden markers and liver and cardiac function in these patients, via a placebo-controlled, crossover clinical study. Silymarin (140 mg) or placebo were administered thrice daily to all patients (n = 82) for 12 weeks, and after a 2-week washout period, patients were crossed over to the other groups...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29234903/biodistribution-and-radiation-dosimetry-of-64cu-copper-dichloride-first-in-human-study-in-healthy-volunteers
#10
M A Avila-Rodriguez, C Rios, J Carrasco-Hernandez, J C Manrique-Arias, R Martinez-Hernandez, F O García-Pérez, A R Jalilian, E Martinez-Rodriguez, M E Romero-Piña, A Diaz-Ruiz
BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. Limited human biodistribution and radiation dosimetry data is available for this tracer. The aim of this research was to determine the biodistribution and estimate the radiation dosimetry of [64Cu]CuCl2, using whole-body (WB) PET scans in healthy volunteers...
December 12, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29234200/nutrition-and-muscle-in-cirrhosis
#11
REVIEW
Anil C Anand
As the cirrhosis progresses, development of complication like ascites, hepatic encephalopathy, variceal bleeding, kidney dysfunction, and hepatocellular carcinoma signify increasing risk of short term mortality. Malnutrition and muscle wasting (sarcopenia) is yet other complications that negatively impact survival, quality of life, and response to stressors, such as infection and surgery in patients with cirrhosis. Conventionally, these are not routinely looked for, because nutritional assessment can be a difficult especially if there is associated fluid retention and/or obesity...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29233685/contrast-enhanced-ultrasound-in-mixed-hepatocellular-cholangiocarcinoma-case-series-and-review-of-the-literature
#12
Yi Dong, Andreas Teufel, Jörg Trojan, Annalisa Berzigotti, Xin Wu Cui, Christoph F Dietrich
BACKGROUND: Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. AIMS: The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. METHODS: Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis...
November 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29233365/acute-trans-diaphragmatic-herniation-of-the-caudate-lobe-of-the-liver
#13
Ioannis Loumiotis, Milan M Kinkhabwala, Amit Bhargava
Diaphragmatic liver herniation is often associated with thoracoabdominal trauma. Spontaneous diaphragmatic rupture is a thoracoabdominal emergency and requires a high index of suspicion combined with high-resolution imaging studies for establishing an accurate and timely diagnosis. We present a case report of a patient who was admitted to the emergency department with severe substernal chest pain and shortness of breath who was diagnosed with spontaneous diaphragmatic rupture and caudate liver herniation. The caudate lobe was incarcerated, contributing to the patient's symptoms...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29232485/retraction-imaging-characteristics-of-liver-langerhans-cell-histiocytosis-in-children-by-hui-liu-xueying-long-xiaoyi-wang-wenzheng-li-and-yigang-pei
#14
(no author information available yet)
The above article from Pediatrics International, published as an Accepted Article online on April 28, 2017 in Wiley Online Library (http://wileyonlinelibrary.com) has been withdrawn by agreement between the authors, the Journal Editor-in-Chief, Atsushi Manabe, and John Wiley & Sons Australia, Ltd, on behalf of the Japan Pediatric Society. The withdrawal has been agreed at the request of the authors who have identified some serious problems that need to be addressed and who have found that some important information is missing...
September 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29232243/artifactual-hepatic-metastasis-on-fdg-pet-ct-secondary-to-cryoablation-for-adrenal-metastasis
#15
Joseph Frankl, Naghmehossadat Eshghi, Tamara F Lundeen, Phillip H Kuo
A 65-year-old woman with metastatic lung cancer was referred for CT-guided cryoablation of a right adrenal metastasis. For cryoablation, probes were placed into the adrenal region. FDG PET/CT 3 months later showed new activity in hepatic segment 6 initially suspected to be metastasis. Proximity of the hepatic lesion to the adrenal metastasis was a strange coincidence and prompted review of imaging from the cryoablation. CT showed the probe entered the liver, and postablation image demonstrated injury to the liver adjacent to the adrenal metastasis...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29232242/prediction-of-posthepatectomy-liver-failure-proposed-by-the-international-study-group-of-liver-surgery-residual-liver-function-estimation-with-99mtc-galactosyl-human-serum-albumin-scintigraphy
#16
Yoichi Mizutani, Toshinori Hirai, Shigeki Nagamachi, Atsushi Nanashima, Koichi Yano, Kazuhiro Kondo, Masahide Hiyoshi, Naoya Imamura, Tamasa Terada
PURPOSE: The International Study Group of Liver Surgery (ISGLS) proposed a definition and grading system for posthepatectomy liver failure (PHLF). We evaluated the usefulness of residual liver function estimation using Tc-galactosyl human serum albumin (Tc-GSA) for the prediction of PHLF. METHODS: Patients with liver tumors (n = 136) and scheduled for hepatectomy underwent Tc-GSA scintigraphy. Based on their imaging data, the maximal GSA removal rate (GSA-Rmax)was calculated using multicompartment analysis...
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29232185/18f-fdg-pet-biomarkers-help-detect-early-metabolic-response-to-irreversible-electroporation-and-predict-therapeutic-outcomes-in-a-rat-liver-tumor-model
#17
Xifu Wang, Zhanliang Su, Tianchu Lyu, Matteo Figini, Daniel Procissi, Junjie Shangguan, Chong Sun, Bin Wang, Na Shang, Shanzhi Gu, Quanhong Ma, Andrew C Gordon, Kai Lin, Jian Wang, Robert J Lewandowski, Riad Salem, Vahid Yaghmai, Andrew C Larson, Zhuoli Zhang
Purpose To test the hypothesis that biomarkers of fluorine 18 (18F) fluorodeoxyglucose (FDG) positron emission tomography (PET) can be used for the early detection of therapeutic response to irreversible electroporation (IRE) of liver tumor in a rodent liver tumor model. Materials and Methods The institutional animal care and use committee approved this study. Rats were inoculated with McA-RH7777 liver tumor cells in the left median and left lateral lobes. Tumors were allowed to grow for 7 days to reach a size typically at least 5 mm in longest diameter, as verified with magnetic resonance (MR) imaging...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29232129/the-effect-of-structural-modifications-to-glyoxalbis-thiosemicarbazanoto-copper-ii-complexes-on-cellular-copper-uptake-copper-mediated-atp7a-trafficking-and-p-glycoprotein-mediated-efflux
#18
Karla M Acevedo, David J Hayne, Lachlan E McInnes, Asif Noor, Clare Duncan, Diane Moujalled, Irene Volitakis, Angela Rigopoulos, Kevin Jeffrey Barnham, Victor L Villemagne, Anthony R White, Paul S Donnelly
Bis(thiosemicarbazonato)copper(II) complexes are of interest as potential therapeutics for cancer and neurodegenerative diseases as well as imaging agents for positron emission tomography (PET). The cellular uptake of six bis(thiosemcarbazonato)copper(II)complexes derived from glyoxal, with different functional groups, Cu(gtsx) where x = different functional groups, was investigated in SKOV-3, HEK293 and HEK293 P-gp cell lines. Treatment of the cells with the copper complexes increased intracellular copper and increased levels of p-ERK due to activation of the Ras-Raf-MEK-ERK pathway...
December 12, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29231883/silver-nanoparticles-in-the-lung-toxic-effects-and-focal-accumulation-of-silver-in-remote-organs
#19
Martin Wiemann, Antje Vennemann, Franziska Blaske, Michael Sperling, Uwe Karst
The distribution of silver (Ag) into remote organs secondary to the application of Ag nanoparticles (Ag-NP) to the lung is still incompletely understood and was investigated in the rat with imaging methods. Dose-finding experiments were carried out with 50 nm- or 200 nm-sized polyvinyl pyrrolidine (PVP)-coated Ag-NP using alveolar macrophages in vitro and female rats, which received Ag-NP via intratracheal instillation. In the main study, we administered 37.5-300 µg per rat lung of the more toxic Ag50-PVP and assessed the broncho-alveolar lavage fluid (BALF) for inflammatory cells, total protein and fibronectin after three and 21 days...
December 12, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29230556/liver-directed-therapy-for-hepatocellular-carcinoma
#20
Kazim H Narsinh, David P Duncan, Isabel G Newton, Jeet Minocha, Steven C Rose
Liver-directed therapy is a critical component of treatment strategies for hepatocellular carcinoma. These therapies included percutaneous image-guided ablation, transarterial chemoembolization, and transarterial radioembolization, and are administered by interventional radiologists. Depending on the stage of disease, a particular treatment modality, or a combination thereof, is expected to be most efficacious in achieving the goals of treatment for a particular patient. This article seeks to review the various liver-directed treatment modalities for treatment of hepatocellular carcinoma, with attention to their efficacy and patient selection criteria...
December 11, 2017: Abdominal Radiology
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