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JOURNAL ARTICLE
Yang Guan, Nannan Zhang, Chengjun Chu, Yang Xiao, Ren Niu, Chaofeng Shao
China suffers from severe surface water pollution. Health impact assessment could provide a novel and quantifiable metric for the health burden attributed to surface water pollution. This study establishes a health impact assessment method for surface water pollution based on classic frameworks, integrating the multi-pollutant city water quality index (CWQI), informative epidemiological findings, and benchmark public health information. A relative risk level assignment approach is proposed based on the CWQI, innovatively addressing the challenge in surface water-human exposure risk assessment...
May 8, 2024: Science of the Total Environment
#22
JOURNAL ARTICLE
Maria Pia Federica Dorma, Giuseppe Giuliani, Francesco Guerra, Francesco Santelli, Alessandro Esposito, Matteo De Pastena, Giulia Turri, Corrado Pedrazzani, Emanuele Federico Kauffmann, Ugo Boggi, Leonardo Solaini, Giorgio Ercolani, Laura Mastrangelo, Elio Jovine, Gregorio Di Franco, Luca Morelli, Michele Mazzola, Giovanni Ferrari, Serena Langella, Alessandro Ferrero, Roberta La Mendola, Mohamnad Abu Hilal, Norma Depalma, Stefano D'Ugo, Marcello Giuseppe Spampinato, Marco Frisini, Alberto Brolese, Raffaele Palaia, Andrea Belli, Nicola Cillara, Antonello Deserra, Alessandro Cannavera, Andrea Sagnotta, Stefano Mancini, Enrico Pinotti, Mauro Montuori, Alessandro Coppola, Fabrizio Di Benedetto, Andrea Coratti
BACKGROUND: In this article we aimed to perform a subgroup analysis using data from the COVID-AGICT study, to investigate the perioperative outcomes of patients undergoing surgery for pancreatic cancers (PC) during the COVID-19 pandemic. METHODS: The primary endpoint of the study was to find out any difference in the tumoral stage of surgically treated PC patients between 2019 and 2020. Surgical and oncological outcomes of the entire cohort of patients were also appraised dividing the entire peri-pandemic period into six three-month timeframes to balance out the comparison between 2019 and 2020...
April 26, 2024: Surgical Oncology
#23
REVIEW
Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat
BACKGROUND AND OBJECTIVES: Pancreatic cancer is one of the most lethal malignancies. Even though many substantial improvements in the survival rates for other major cancer forms were made, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Even more, no standard classification system for pancreatic cancer is based on cellular biomarkers. This review will discuss and provide updates about the role of stem cells in the progression of PC, the genetic changes associated with it, and the promising biomarkers for diagnosis...
May 1, 2024: Pancreas
#24
JOURNAL ARTICLE
Tiago M A Carvalho, Madelaine Magalì Audero, Maria Raffaella Greco, Marilena Ardone, Teresa Maggi, Rosanna Mallamaci, Barbara Rolando, Silvia Arpicco, Federico Alessandro Ruffinatti, Alessandra Fiorio Pla, Natalia Prevarskaya, Tomas Koltai, Stephan J Reshkin, Rosa Angela Cardone
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with high mortality due to early metastatic dissemination and high chemoresistance. All these factors are favored by its extracellular matrix (ECM)-rich microenvironment, which is also highly hypoxic and acidic. Gemcitabine (GEM) is still the first-line therapy in PDAC. However, it is quickly deaminated to its inactive metabolite. Several GEM prodrugs have emerged to improve its cytotoxicity. Here, we analyzed how the acidic/hypoxic tumor microenvironment (TME) affects the response of PDAC cell death and invadopodia-mediated ECM proteolysis to both GEM and its C18 prodrug...
April 23, 2024: Cells
#25
JOURNAL ARTICLE
Dustin L Dillon, Joon Y Park, Michael A Mederos, Young-Ji Seo, Jonathan King, Joe Hines, Timothy Donahue, Mark D Girgis
BACKGROUND AND OBJECTIVES: Neoadjuvant chemotherapy (NAC) is becoming favored for all pancreatic adenocarcinoma (PDAC). Patients with seemingly resectable disease infrequently still display vascular involvement intraoperatively. Outcomes following NAC versus upfront surgery in patients undergoing pancreaticoduodenectomy (PD) with vascular resection are unknown. METHODS: We performed a retrospective cohort study of PDAC patients who underwent PD with vascular resection between January 1, 2013, to December 31, 2020, within a single academic center...
May 10, 2024: Journal of Surgical Oncology
#26
JOURNAL ARTICLE
Chengxiao Yang, Gang Quan, Shihang Zhang, Jianxin Jiang
Recent studies have indicated that the dual-specificity phosphatases (DUSP) family may play a role in the advancement of pancreatic cancer. Exploring the role of the DUSP family in pancreatic cancer development and discovering novel therapeutic targets are crucial for pancreatic cancer therapy. A critical subset of 20 genes exhibiting differential expression was identified, with particular emphasis on four key genes: DUSP10, PTP4A2, SSH3, and CDKN3 by multivariate Cox proportional hazards analysis. These genes were integral to developing a novel risk model for PC, which has been independently validated as a prognostic factor for patients...
2024: American Journal of Cancer Research
#27
REVIEW
MicroRNAs as the critical regulators of epithelial mesenchymal transition in pancreatic tumor cells.
Faezeh Tolue Ghasaban, Mahmoud Ghanei, Reihaneh Alsadat Mahmoudian, Negin Taghehchian, Mohammad Reza Abbaszadegan, Meysam Moghbeli
Pancreatic cancer (PC), as one of the main endocrine and digestive systems malignancies has the highest cancer related mortality in the world. Lack of the evident clinical symptoms and appropriate diagnostic markers in the early stages of tumor progression are the main reasons of the high mortality rate among PC patients. Therefore, it is necessary to investigate the molecular pathways involved in the PC progression, in order to introduce novel early diagnostic methods. Epithelial mesenchymal transition (EMT) is a critical cellular process associated with pancreatic tumor cells invasion and distant metastasis...
May 15, 2024: Heliyon
#28
REVIEW
Yuhan Huang, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Pancreatic cancer is a malignancy with high mortality. In addition to the few symptoms until the disease reaches an advanced stage, the high fatality rate is attributed to its rapid development, drug resistance and lack of appropriate treatment. In the selection and research of therapeutic drugs, gemcitabine is the first-line drug for pancreatic cancer. Solving the problem of gemcitabine resistance in pancreatic cancer will contribute to the progress of pancreatic cancer treatment. Long non coding RNAs (lncRNAs), which are RNA transcripts longer than 200 nucleotides, play vital roles in cellular physiological metabolic activities...
2024: International Journal of Biological Sciences
#29
Benjamin F Cardenas, Ayeetin M Azah, Azfar S Syed, Jeffrey T Laczek
We report a case of pancreatic myeloid sarcoma (MS), an extremely rare manifestation of acute myeloid leukemia (AML), in a 35-year-old male who presented with epigastric pain and watery stools. Initial diagnostic testing was inconclusive; however, following an extensive evaluation, endoscopic biopsies suggested AML, which was confirmed by a bone marrow biopsy. Given that few cases are documented in the literature, pancreatic MS without a preexisting hematologic malignancy poses a significant diagnostic challenge...
April 2024: Curēus
#30
JOURNAL ARTICLE
Min Deng, Jianhua Cao, Gregory van der Kroft, David P J van Dijk, Merel R Aberle, Andrej Grgic, Ulf P Neumann, Georg Wiltberger, Benjamin Balluff, Frank G Schaap, Ron M A Heeren, Steven W M Olde Damink, Sander S Rensen
BACKGROUND: Cancer cachexia is a multifactorial metabolic syndrome characterized by systemic inflammation and ongoing skeletal muscle loss resulting in weakness, poor quality of life, and decreased survival. Whereas lipid accumulation in skeletal muscle is associated with cancer cachexia as well as the prognosis of cancer patients, surprisingly little is known about the nature of the lipids that accumulate in the muscle during cachexia, and whether this is related to inflammation. We aimed to identify the types and distributions of intramyocellular lipids in patients with and without cancer cachexia...
May 9, 2024: Journal of Cachexia, Sarcopenia and Muscle
#31
JOURNAL ARTICLE
Yusuke Seiki, Kenji Ikezawa, Ko Watsuji, Makiko Urabe, Yugo Kai, Ryoji Takada, Takuo Yamai, Kaori Mukai, Tasuku Nakabori, Hiroyuki Uehara, Miki Ishibashi, Kazuyoshi Ohkawa
BACKGROUND: Although patients with advanced pancreatic cancer (PC) often experience dysgeusia with zinc deficiency during chemotherapy, data on zinc supplementation for dysgeusia and its effects on nutritional status are scarce. We aimed to examine the efficacy of zinc supplementation in patients with advanced PC. METHODS: Thirty-three patients with unresectable PC who presented with dysgeusia and zinc deficiency during chemotherapy and received zinc acetate hydrate between January 2018 and December 2022 were included...
May 10, 2024: International Journal of Clinical Oncology
#32
JOURNAL ARTICLE
Qiqi Wang, Mengyuan Gong, Rujuan Liu, Jiantao Mo, Ruiping Bai, Rui An, Xueni Wang, Liang Han, Zheng Wang, Qingyong Ma, Zheng Wu, Cancan Zhou
BACKGROUND: Gemcitabine is the first-line chemotherapy drug that can easily cause chemotherapy resistance. Huaier is a traditional Chinese medicine and shows an antitumor effect in pancreatic cancer, but whether it can enhance the gemcitabine chemotherapeutic response and the potential mechanism remain unknown. PURPOSE: This study was performed to explore the effect of Huaier in promoting the tumor-killing effect of gemcitabine and elucidate the possible mechanism in pancreatic cancer...
April 26, 2024: Phytomedicine
#33
JOURNAL ARTICLE
Huong Chi Mai Tran, Elisabeth Mbemba, Noémie Mourot, Beshoy Faltas, Aurélie Rousseau, Elmina Lefkou, Michèle Sabbah, Patrick van Dreden, Grigoris Gerotziafas
INTRODUCTION: Cancer cells induce hypercoagulability in the tumoral microenvironment by expressing Tissue Factor (TF). We aimed to study the impact of the procoagulant signature of cancer cells on the quality and structure of fibrin network. We also studied the impact of fibrin clot shield (FCS) on the efficiency of anticancer agents and the migration of cancer cells. MATERIALS AND METHODS: Pancreatic cancer cells BXPC3 and breast cancer cells MDA-MB231 and MCF7, were cultured in the presence of normal Platelet Poor Plasma (PPP), diluted 10 % in conditioning media...
April 17, 2024: Thrombosis Research
#34
JOURNAL ARTICLE
Jiliang Zhao, Han Wang, Jinhua Chen, Chunlei Wang, Nanxin Gong, Feilong Zhou, Xin Li, Youjia Cao, Hongkai Zhang, Wei Wang, Hao Zheng, Cuizhu Zhang
Oncolytic viruses (OVs) have shown potential in converting a "cold" tumor into a "hot" one and exhibit effectiveness in various cancer types. However, only a subset of patients respond to oncolytic virotherapy. It is important to understand the resistance mechanisms to OV treatment in pancreatic ductal adenocarcinoma (PDAC) to engineer oncolytic viruses. In this study, we used transcriptome RNA sequencing (RNA-seq) to identify Visfatin, which was highly expressed in the responsive tumors following OV treatment...
April 12, 2024: Biochemical and Biophysical Research Communications
#35
JOURNAL ARTICLE
Naveena A N Kumar
No abstract text is available yet for this article.
May 9, 2024: Annals of Surgical Oncology
#36
JOURNAL ARTICLE
Haoyu An, Hanqian Dai, Xiaomeng Liu
AIM: To explore the global burden of pancreatic cancer (PC) from 1990 to 2019, evaluate independent effects of age, period, and cohort on the incidence of PC, and predict the incidence of PC in the next decade. METHODS: Data were obtained from the Global Burden of Disease Study 2019. We calculated the age-standardized disability-adjusted life years (DALY) rate, age-standardized mortality rate (ASMR), age-standardized incidence rate (ASIR), and age-standardized prevalence rate (ASPR) of PC...
May 9, 2024: Digestive Diseases and Sciences
#37
JOURNAL ARTICLE
Jibran Ahmed, Bettzy Stephen, Yali Yang, Evan Kwiatkowski, Chinenye Lynette Ejezie, Shubham Pant
INTRODUCTION: Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resistance to this blockade. Combining spartalizumab (PDR001), a high-affinity, ligand-blocking, humanized anti-PD-1 immunoglobulin G4 antibody, with lacnotuzumab (MCS110), a high-affinity, humanized monoclonal antibody directed against human CSF-1 can potentially overcome this resistance...
May 2024: Journal of immunotherapy and precision oncology
#38
JOURNAL ARTICLE
Miki Gibo, Seiji Kojima, Akinori Fujisawa, Takayuki Kikuchi, Masanori Fukushima
During the COVID-19 pandemic, excess deaths including cancer have become a concern in Japan, which has a rapidly aging population. Thus, this study aimed to evaluate how age-adjusted mortality rates (AMRs) for different types of cancer in Japan changed during the COVID-19 pandemic (2020-2022). Official statistics from Japan were used to compare observed annual and monthly AMRs with predicted rates based on pre-pandemic (2010-2019) figures using logistic regression analysis. No significant excess mortality was observed during the first year of the pandemic (2020)...
April 2024: Curēus
#39
JOURNAL ARTICLE
Purvish M Parikh, Tarini P Sahoo, Ghanashyam Biswas, Vineet Talwar, Somashekhar Sp, Soumya Surath Panda, Avinash Cb, Nishita Shetty, Anita Ramesh, Joydeep Ghosh, Vijith Vital Shetty, Radheshyam Naik, Ashish Singh, Gaurav Gupta, Bhavesh Parekh
Purvish M ParikhS-1 (5-fluorouracil prodrug [tegafur] in combination with 5-chloro-2,4-dihydroxypyridine [CDHP] and potassium oxonate [OXO]) was first approved in 1999. In order to make it easy for community oncologists, we decided to put together this expert consensus guideline for its use in gastrointestinal (GI) malignancies. A total of 15 subject matter experts used modified Delphi method to discuss, analyze, and vote on key aspects regarding practical approach to use of S-1 in GI cancers, a process involving 6 months of work...
January 2024: South Asian Journal of Cancer
#40
REVIEW
Yongjiang Zhou, Jiajie Feng, Qingqing Wang, Yiwen Zhao, Hanyu Ding, Kexin Jiang, Hua Ji, Zheng Tang, Ruiwu Dai
OBJECTIVE: This review aims to provide a quantitative and qualitative bibliometric analysis of literature from 2013 to 2023 on the role of exosomes in PC, with the goal of identifying current trends and predicting future hotspots. METHODS: We retrieved relevant publications concerning exosomes in PC, published between 2013 and 2023, from the Web of Science Core Collection. Bibliometric analyses were conducted using VOSviewer(1.6.19), CiteSpace(6.2.R4), and Microsoft Excel (2019)...
2024: Frontiers in Oncology
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