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Pleural lavage

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https://www.readbyqxmd.com/read/27894300/pleural-inhibition-of-the-caspase-1-il-1%C3%AE-pathway-diminishes-profibrotic-lung-toxicity-of-bleomycin
#1
Olivier Burgy, Pierre-Simon Bellaye, Sebastien Causse, Guillaume Beltramo, Guillaume Wettstein, Pierre-Marie Boutanquoi, Françoise Goirand, Carmen Garrido, Philippe Bonniaud
BACKGROUND: Idiopathic and toxic pulmonary fibrosis are severe diseases starting classically in the subpleural area of the lung. It has recently been suggested that pleural mesothelial cells acquire a myofibroblast phenotype under fibrotic conditions induced by TGF-β1 or bleomycin. The importance and role of inflammation in fibrogenesis are still controversial. In this work, we explored the role of IL-1β/caspase-1 signaling in bleomycin lung toxicity and in pleural mesothelial cell transformation...
November 29, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27833109/intrapleural-adenoviral-mediated-endothelial-cell-protein-c-receptor-gene-transfer-suppresses-the-progression-of-malignant-pleural-mesothelioma-in-a-mouse-model
#2
Shiva Keshava, L Vijaya Mohan Rao, Usha R Pendurthi
Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer with a high mortality rate as it responds poorly to standard therapeutic interventions. Our recent studies showed that expression of endothelial cell protein C receptor (EPCR) in MPM cells suppresses tumorigenicity. The present study was aimed to investigate the mechanism by which EPCR suppresses MPM tumor growth and evaluate whether EPCR gene therapy could suppress the progression of MPM in a mouse model of MPM. Measurement of cytokines from the pleural lavage showed that mice implanted with MPM cells expressing EPCR had elevated levels of IFNγ and TNFα compared to mice implanted with MPM cells lacking EPCR...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27826770/endobronchial-naso-bronchial-lavage-an-alternative-interventional-treatment-for-post-lobectomy-bronchopleural-fistula
#3
Ye Ning, Hai Huang, Lei Xue, Xuewei Zhao
BACKGROUND AND STUDY AIMS: Post-lobectomy bronchopleural fistula is a rare complication of lung resection surgery, and proper management is crucial for the successful resolution. Most published papers deal with surgical treatment. We report our experience with a new interventional management, endobronchial naso-bronchial lavage (ENBL). The aim of this study was to evaluate the continuing efficacy and safety of this innovative procedure. PATIENTS AND METHODS: From 2002 to 2012, 17 patients who suffered from post-lobectomy bronchopleural fistula were recruited...
November 8, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27800290/antibiogram-of-medical-intensive-care-unit-at-tertiary-care-hospital-setting-of-pakistan
#4
Aayesha Qadeer, Aftab Akhtar, Qurat Ul Ain, Shoab Saadat, Salman Mansoor, Salman Assad, Wasib Ishtiaq, Abid Ilyas, Ali Y Khan, Yousaf Ajam
OBJECTIVE:  To determine the frequency of micro-organisms causing sepsis as well as to determine the antibiotic susceptibility and resistance of microorganisms isolated in a medical intensive care unit. MATERIALS AND METHODS:  This is a cross-sectional analysis of 802 patients from a medical intensive care unit (ICU) of Shifa International Hospital, Islamabad, Pakistan over a one-year period from August 2015 to August 2016. Specimens collected were from blood, urine, endotracheal secretions, catheter tips, tissue, pus swabs, cerebrospinal fluid, ascites, bronchoalveolar lavage (BAL), and pleural fluid...
September 29, 2016: Curēus
https://www.readbyqxmd.com/read/27550908/asbestos-bodies-in-bronchoalveolar-lavage-in-the-21st-century-a-time-trend-analysis-in-a-clinical-population
#5
Valerie Nuyts, Hadewijch Vanhooren, Sarah Begyn, Kristiaan Nackaerts, Benoit Nemery
OBJECTIVES: Asbestos bodies (AB) in bronchoalveolar lavage (BAL) can be detected by light microscopy and their concentration is indicative of past cumulative asbestos exposure. We assessed clinical and exposure characteristics, as well as possible time trends, among patients in whom AB had been quantified in BAL. METHODS: BAL samples obtained from 578 participants between January 1997 and December 2014 were available for analysis. The processing of samples and the microscopic analysis were performed by a single expert and 76% of samples came from a single tertiary care hospital, allowing clinical and exposure data to be extracted from patient files...
August 22, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27524978/direct-molecular-diagnosis-of-aspergillosis-and-cyp51a-profiling-from-respiratory-samples-of-french-patients
#6
Yanan Zhao, Cécile Garnaud, Marie-Pierre Brenier-Pinchart, Anne Thiébaut-Bertrand, Christel Saint-Raymond, Boubou Camara, Rebecca Hamidfar, Odile Cognet, Danièle Maubon, Muriel Cornet, David S Perlin
BACKGROUND: Microbiological diagnosis of aspergillosis and triazole resistance is limited by poor culture yield. To better estimate this shortcoming, we compared culture and molecular detection of A. fumigatus in respiratory samples from French patients at risk for aspergillosis. METHODS: A total of 97 respiratory samples including bronchoalveolar lavages (BAL), bronchial aspirates (BA), tracheal aspirates, sputa, pleural fluids, and lung biopsy were collected from 33 patients having invasive aspergillosis (n = 12), chronic pulmonary aspergillosis (n = 3), allergic bronchopulmonary aspergillosis (n = 7), or colonization (n = 11) and 28 controls...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27513332/anti-vascular-endothelial-growth-factor-antibody-suppresses-erk-and-nf-%C3%AE%C2%BAb-activation-in-ischemia-reperfusion-lung-injury
#7
Chou-Chin Lan, Chung-Kan Peng, Shih-En Tang, Shu-Yu Wu, Kun-Lun Huang, Chin-Pyng Wu
Ischemia-reperfusion (IR)-induced acute lung injury (ALI) is implicated in several clinical conditions like lung transplantation, acute pulmonary embolism after thrombolytic therapy, re-expansion of collapsed lung from pneumothorax or pleural effusion, cardiopulmonary bypass and etc. Because mortality remains high despite advanced medical care, prevention and treatment are important clinical issues for IR-induced ALI. Vascular endothelial growth factor (VEGF) has a controversial role in ALI. We therefore conducted this study to determine the effects of anti-VEGF antibody in IR-induced ALI...
2016: PloS One
https://www.readbyqxmd.com/read/27476564/-lung-cancer-incidentally-detected-by-a-subcutaneous-nodule-at-the-drainage-site-for-pneumothorax
#8
Jumpei Okamoto, Isao Matsumoto, Daisuke Saito, Shuhei Yoshida, Munehisa Takada, Masaya Tamura, Hirofumi Takemura, Hiroko Ikeda
A 43-year-old male patient underwent thoracic drainage for the treatment of right pneumothorax. After 6 months, the patient visited our department because of a subcutaneous nodule found at the drainage site. Chest computed tomography revealed a mass lesion associated with a cavity in the right upper lobe of the lung and a subcutaneous nodule. Surgical resection was performed and both the pulmonary lesion and subcutaneous nodule were found to be adenocarcinoma. Although immunohistochemical analysis suggested that the pulmonary lesion was primary lung cancer, there were neither intrathoracic exposure of the tumor nor tumor cells in the pleural lavage cytology...
August 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27458805/prognostic-value-of-pleural-lavage-cytology-in-patients-with-lung-cancer-resection-an-updated-meta-analysis
#9
Chun-Mei Wang, Zhou-Gui Ling, Yan-Bin Wu, Shuang-Qi Cai, Zhen-Ming Tang, Cong Wu, Yi-Qiang Chen
OBJECTIVE: Pleural lavage cytology (PLC) is considered as a possible tool for assessing prognosis of lung cancer patients. We aimed to comprehensively review the prognosis value of PLC in patients undergoing surgical resection. METHODS: We searched 4 electronic databases for relevant studies comparing positive PLC and negative PLC. The primary outcomes included survival rate and recurrence rate at maximum follow-up. RESULTS: The meta-analysis included 28 studies, with a total of 20,714 patients...
2016: PloS One
https://www.readbyqxmd.com/read/27271877/organizing-empyema-induced-in-mice-by-streptococcus-pneumoniae-effects-of-plasminogen-activator-inhibitor-1-deficiency
#10
Torry A Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A Komissarov, Mitsuo Ikebe, Steven Idell
BACKGROUND: Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition (MT), by which PMCs acquire a profibrogenic phenotype with increased expression of α-smooth muscle actin (α-SMA) and matrix proteins. MesoMT thereby contributes to pleural organization with fibrosis and lung restriction. Current murine empyema models are characterized by early mortality, limiting analysis of the pathogenesis of pleural organization and mechanisms that promote MesoMT after infection...
December 2016: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/27259835/pulmonary-and-pleural-inflammation-after-intratracheal-instillation-of-short-single-walled-and-multi-walled-carbon-nanotubes
#11
Katsuhide Fujita, Makiko Fukuda, Shigehisa Endoh, Junko Maru, Haruhisa Kato, Ayako Nakamura, Naohide Shinohara, Kanako Uchino, Kazumasa Honda
Relationships between the physical properties of carbon nanotubes (CNTs) and their toxicities have been studied. However, little research has been conducted to investigate the pulmonary and pleural inflammation caused by short-fiber single-walled CNTs (SWCNTs) and multi-walled CNTs (MWCNTs). This study was performed to characterize differences in rat pulmonary and pleural inflammation caused by intratracheal instillation with doses of 0.15 or 1.5mg/kg of either short-sized SWCNTs or MWCNTs. Data from bronchoalveolar lavage fluid analysis, histopathological findings, and transcriptional profiling of rat lungs obtained over a 90-day period indicated that short SWCNTs caused persistent pulmonary inflammation...
August 22, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27188891/increased-concentrations-of-soluble-b7-h3-and-interleukin-36-in-bronchoalveolar-lavage-fluid-of-children-with-mycoplasma-pneumoniae-pneumonia
#12
Zhengrong Chen, Xin Zhao, Xinxing Zhang, Guangbo Zhang, Huiming Sun, Wujun Jiang, Yuqing Wang, Canhong Zhu, Wei Ji, Yongdong Yan
BACKGROUND: The purpose of this study is to explore the correlations of interleukin 36 (IL-36) and Soluble B7-H3 (sB7-H3) levels in bronchoalveolar lavage fluid (BALF) with clinical characteristics and laboratory findings. METHODS: A total of 35 children with M. pneumnoiae pneumonia (MPP) and 15 control subjects were enrolled. BALF concentrations of sB7-H3 and IL-36 were detected using enzyme-linked immunosorbent assays and clinical profiles of children with MPP were obtained...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27159517/pathology-image-of-the-month-cough-and-shortness-of-breath-in-a-noncompliant-patient-with-hiv-aids
#13
Reggie Thomasson, Tracy Dewenter, Robin R McGoey
A 37- year-old man with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) was admitted to the intensive care unit following a four month history of progressive shortness of breath, productive cough, and flu-like symptoms. His HIV/AIDS was diagnosed at the age of 19 (CD4 count =15; viral load = 294,436 copies/ mL) and was complicated by hemodialysis-dependent, HIV-associated nephropathy, prior Pneumocystis pneumonia and known noncompliance with prescribed antiretroviral therapy. Chest film at admission was interpreted as diffuse bilateral interstitial and airspace opacities with a right sided layering density representative of laminar pleural effusion...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27152578/microstructured-optical-fiber-based-biosensors-reversible-and-nanoliter-scale-measurement-of-zinc-ions
#14
Sabrina Heng, Christopher A McDevitt, Roman Kostecki, Jacqueline R Morey, Bart A Eijkelkamp, Heike Ebendorff-Heidepriem, Tanya M Monro, Andrew D Abell
Sensing platforms that allow rapid and efficient detection of metal ions would have applications in disease diagnosis and study, as well as environmental sensing. Here, we report the first microstructured optical fiber-based biosensor for the reversible and nanoliter-scale measurement of metal ions. Specifically, a photoswitchable spiropyran Zn(2+) sensor is incorporated within the microenvironment of a liposome attached to microstructured optical fibers (exposed-core and suspended-core microstructured optical fibers)...
May 25, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27138544/pathology-image-of-the-month-cough-and-shortness-of-breath-in-a-noncompliant-patient-with-hiv-aids
#15
Reggie Thomasson Md, Tracy Dewenter Md, Robin R McGoey Md
A 37- year-old man with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) was admitted to the intensive care unit following a four month history of progressive shortness of breath, productive cough, and flu-like symptoms. His HIV/AIDS was diagnosed at the age of 19 (CD4 count =15; viral load = 294,436 copies/ mL) and was complicated by hemodialysis-dependent, HIV-associated nephropathy, prior Pneumocystis pneumonia and known noncompliance with prescribed antiretroviral therapy. Chest film at admission was interpreted as diffuse bilateral interstitial and airspace opacities with a right sided layering density representative of laminar pleural effusion...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27130425/reactive-oxygen-species-measure-for-rapid-detection-of-infection-in-fluids
#16
Jean Bardon, Anne-Claire Lukaszewicz, Valérie Faivre, Benjamin Huot, Didier Payen
BACKGROUND: Early detection of infection is critical to rapidly starting effective treatment. Diagnosis can be difficult, particularly in the intensive care unit (ICU) population. Because the presence of polymorphonuclear neutrophils in tissues is the hallmark of inflammatory processes, the objective of this proof of concept study was to determine whether the measurement of reactive oxygen species (ROS) could be an efficient diagnostic tool to rapidly diagnose infections in peritoneal, pleural and bronchoalveolar lavage (BAL) fluids in ICU patients...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27092683/-chronic-eosinophilic-pneumonia-report-of-one-case
#17
Sebastián Fernández-Bussy, Felipe Campos, Isabel Ogueta, Gonzalo Labarca, Hernán Cabello
Chronic eosinophilic pneumonia (CEP) is uncommon and predominantly seen in women. More than 6% of eosinophils in peripheral blood and more than 25% in bronchoalveolar lavage are diagnostic criteria. Secondary causes of hypereosinophilic pneumonia must be ruled out. We report a 72-year-old non-smoker man presenting in the emergency room with a history of cough, fever, and moderate dyspnea. He was not taking any medication. A chest-X ray showed a left lower lobe (LLL) consolidation, and was started on broad-spectrum antibiotics with a presumptive diagnosis of pneumonia...
February 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27055072/malignant-pleural-effusions-because-of-lung-cancer
#18
José M Porcel
PURPOSE OF REVIEW: The discovery of a pleural effusion in the setting of lung cancer has diagnostic, prognostic, and therapeutic challenges, some of which are addressed in this review. RECENT FINDINGS: Around 20% of patients with lung cancer have minimal pleural effusions, which are not amenable to a diagnostic thoracentesis. These patients have a poorer overall survival (∼7.5 months) than those without effusions (∼12-18 months), although slightly better than those with proven malignant fluids (∼5...
July 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27038661/thoracic-irrigation-prevents-retained-hemothorax-a-pilot-study
#19
Nathan W Kugler, Thomas W Carver, Jasmeet S Paul
BACKGROUND: Upward of 20% of patients undergoing thoracostomy tube (TT) placement develop retained hemothorax (HTx) requiring secondary intervention. The aim of this study was to define the rate of secondary intervention in patients undergoing prophylactic thoracic irrigation. METHODS: A prospective observational trial of 20 patients who underwent thoracic irrigation at the time of TT placement was conducted. Patients with HTx identified on chest x-ray were included...
May 15, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27038519/uvaol-attenuates-pleuritis-and-eosinophilic-inflammation-in-ovalbumin-induced-allergy-in-mice
#20
Lais Costa Agra, Marvin Paulo Lins, Patrícia da Silva Marques, Salete Smaniotto, Christianne Bandeira de Melo, Vincent Lagente, Emiliano Barreto
Uvaol, a triterpene present in olives and virgin olive oil, has been shown to possess anti-inflammatory properties and antioxidant effects. However, until now, no studies have demonstrated its potential effects on allergic inflammation. The aim of this study was to evaluate the anti-inflammatory effects of uvaol in a mouse model of allergy characterized by eosinophil-dominant inflammation in actively sensitized mice. The anti-inflammatory effect of uvaol was analyzed in two murine models of allergic inflammation (pleurisy and asthma)...
June 5, 2016: European Journal of Pharmacology
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