keyword
MENU ▼
Read by QxMD icon Read
search

Effexor

keyword
https://www.readbyqxmd.com/read/27822048/analysis-of-treatment-patterns-and-persistence-on-branded-and-generic-medications-in-major-depressive-disorder-using-retrospective-claims-data
#1
Caitlyn T Solem, Ahmed Shelbaya, Yin Wan, Chinmay G Deshpande, Jose Alvir, Elizabeth Pappadopulos
BACKGROUND: In major depressive disorder (MDD), treatment persistence is critical to optimize symptom remission, functional recovery, and health care costs. Desvenlafaxine tends to have fewer drug interactions and better tolerability than other MDD drugs; however, its use has not been assessed in the real world. OBJECTIVE: The aim of the present study is to compare medication persistence and concomitant MDD drug use with branded desvenlafaxine (Pristiq(®)) compared with antidepressant drug groups classified as 1) branded selective serotonin reuptake inhibitors (SSRIs; ie, escitalopram [Lexapro™]) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs; ie, venlafaxine [Effexor(®)], duloxetine [Cymbalta(®)]) and 2) generic SSRIs/SNRIs (ie, escitalopram, citalopram, venlafaxine, fluvoxamine, fluoxetine, sertraline, paroxetine, and duloxetine)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27283470/the-antidepressant-venlafaxine-may-act-as-a-neurodevelopmental-toxicant-in-cuttlefish-sepia-officinalis
#2
Flavie Bidel, Carole Di Poi, Hélène Budzinski, Patrick Pardon, William Callewaert, Adeline Arini, Niladri Basu, Ludovic Dickel, Cécile Bellanger, Christelle Jozet-Alves
The Serotonin/Norepinephrine Reuptake Inhibitor (SNRI) antidepressant venlafaxine (VEN, Effexor(®)) has become one of the most common antidepressants detected in North American and European streams. Mammalian research has established that VEN exposure is associated with a range of structural, neurochemical, and functional alterations of the brain in adults and newborns. However, the neurodevelopmental effects of VEN on non-target organisms have never been investigated. The aim of our research was to decrease this gap in knowledge by characterizing the effects of VEN exposure on a cephalopod mollusk, the common cuttlefish Sepia officinalis...
July 2016: Neurotoxicology
https://www.readbyqxmd.com/read/25880836/differential-co-expression-and-regulation-analyses-reveal-different-mechanisms-underlying-major-depressive-disorder-and-subsyndromal-symptomatic-depression
#3
COMPARATIVE STUDY
Fan Xu, Jing Yang, Jin Chen, Qingyuan Wu, Wei Gong, Jianguo Zhang, Weihua Shao, Jun Mu, Deyu Yang, Yongtao Yang, Zhiwei Li, Peng Xie
BACKGROUND: Recent depression research has revealed a growing awareness of how to best classify depression into depressive subtypes. Appropriately subtyping depression can lead to identification of subtypes that are more responsive to current pharmacological treatment and aid in separating out depressed patients in which current antidepressants are not particularly effective. Differential co-expression analysis (DCEA) and differential regulation analysis (DRA) were applied to compare the transcriptomic profiles of peripheral blood lymphocytes from patients with two depressive subtypes: major depressive disorder (MDD) and subsyndromal symptomatic depression (SSD)...
April 3, 2015: BMC Bioinformatics
https://www.readbyqxmd.com/read/25869450/mini-tablets-versus-pellets-as-promising-multiparticulate-modified-release-delivery-systems-for-highly-soluble-drugs
#4
Dina M Gaber, Noha Nafee, Osama Y Abdallah
Whether mini-tablets (tablets, diameters ≤6mm) belong to single- or multiple-unit dosage forms is still questionable. Accordingly, Pharmacopoeial evaluation procedures for mini-tablets are lacking. In this study, the aforementioned points were discussed. Moreover, their potential for oral controlled delivery was assessed. The antidepressant venlafaxine hydrochloride (Vx), a highly soluble drug undergoing first pass effect, low bioavailability and short half-life was selected as a challenging payload. In an attempt to weigh up mini-tablets versus pellets as multiparticulate carriers, Vx-loaded mini-tablets were compared to formulated pellets of the same composition and the innovator Effexor(®)XR pellets...
July 5, 2015: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/25822610/modified-regulatory-pathways-to-approve-generic-drugs-in-the-us-and-a-systematic-review-of-their-outcomes
#5
REVIEW
Aaron S Kesselheim, Jennifer M Polinski, Lisa A Fulchino, Danielle L Isaman, Joshua J Gagne
BACKGROUND: Generic drugs are approved on the basis of pharmaceutical equivalence and bioequivalence. Some drug products have unique structural or functional attributes, necessitating modified approaches to bioequivalence determinations. OBJECTIVE: The aim of this systematic review was to identify studies that evaluated laboratory or clinical outcomes of six drugs approved via modified bioequivalence approaches. DATA SOURCES: We conducted a systematic review of articles published through February 2014 in MEDLINE, EMBASE, and International Pharmaceutical Abstracts related to six recent drugs subject to modified regulatory approaches: venlafaxine extended release tablet (Effexor XR), acarbose (Precose), enoxaparin (Lovenox), vancomycin capsules (Vancocin), sodium ferric gluconate (Ferrlecit), and calcitonin salmon nasal spray (Miacalcin NS)...
April 2015: Drugs
https://www.readbyqxmd.com/read/25481651/the-antidepressants-venlafaxine-effexor-and-fluoxetine-prozac-produce-different-effects-on-locomotion-in-two-species-of-marine-snail-the-oyster-drill-urosalpinx-cinerea-and-the-starsnail-lithopoma-americanum
#6
Peter P Fong, Taylor B Bury, Abigail D Dworkin-Brodsky, Christina M Jasion, Rose C Kell
Human antidepressants have been previously shown to induce foot detachment from the substrate in aquatic snails. Prior to foot detachment, antidepressants also affect snail crawling speed. We tested two commonly prescribed antidepressants, venlafaxine ("Effexor") and fluoxetine ("Prozac") on crawling speed and time to reach the air-water interface in two species of marine snail, the oyster drill Urosalpinx cinerea and the American starsnail Lithopoma americanum. Exposure to venlafaxine increased crawling speed in both species, while fluoxetine slowed them down...
February 2015: Marine Environmental Research
https://www.readbyqxmd.com/read/24314785/treatment-of-hidradenitis-supprurativa-associated-pain-with-nonsteroidal-anti-inflammatory-drugs-acetaminophen-celecoxib-gabapentin-pegabalin-duloxetine-and-venlafaxine
#7
REVIEW
Noah Scheinfeld
Hidradenitis Supprurativa is a painful dermatological condition. Although the pain of HS has unique aspects, the pain of HS pain shares common elements with essential pain, fibromyalgia, and pure neuropathic pain syndromes. Futhermore, depression plays an important role in the pain of HS. This paper reviews the potential for use of nonsteroidal anti-inflammatory drug (NSAIDS), acetaminophen, celecoxib, gabpentin, pregabalin, and the serotonin and norepinephrine reuptake inhibitors (SNRIs), duloxetine and venlafaxine, for treating HS related pain...
November 2013: Dermatology Online Journal
https://www.readbyqxmd.com/read/24016243/selective-serotonin-reuptake-inhibitor-ssri-toxicosis-in-cats-33-cases-2004-2010
#8
Cassandra M Pugh, Joseph T Sweeney, Christopher P Bloch, Justine A Lee, Justine A Johnson, Lynn R Hovda
OBJECTIVE: To evaluate a population of cats with selective-serotonin reuptake inhibitor (SSRI) toxicosis and characterize the population affected, list products ingested, the clinical signs observed, treatments performed, length of hospitalization, patient outcome, and overall prognosis. DESIGN: Retrospective study from 2004 to 2010. SETTING: Referral veterinary center. ANIMALS: Thirty-three witnessed cat SSRI ingestions...
September 2013: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/23281074/association-between-reported-venlafaxine-use-in-early-pregnancy-and-birth-defects-national-birth-defects-prevention-study-1997-2007
#9
Kara N D Polen, Sonja A Rasmussen, Tiffany Riehle-Colarusso, Jennita Reefhuis
BACKGROUND: Few epidemiologic studies have investigated the use of venlafaxine (Effexor XR capsules, Product Monograph, Wyeth, Montreal, Canada), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine during pregnancy is associated with specific birth defects. METHODS: We used data from the National Birth Defects Prevention Study (NBDPS), a population-based, case-control study in the United States...
January 2013: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/23218553/antidepressants-cause-foot-detachment-from-substrate-in-five-species-of-marine-snail
#10
Peter P Fong, Nikolett Molnar
Active Pharmaceutical Ingredients (APIs) are released into aquatic ecosystems through discharged sewage wastewater. Antidepressants are among those APIs often detected in wastewater effluent and have been recently reported to cause foot detachment from the substrate in freshwater snails. We tested the effects of four commonly prescribed antidepressants {fluoxetine ("Prozac"), fluvoxamine ("Luvox"), venlafaxine ("Effexor"), and citalopram ("Celexa") on adhesion to the substrate in five species of marine snails, three from the Pacific coast (Chlorostoma funebralis, Nucella ostrina, Urosalpinx cinerea) and two species from the Atlantic coast (Tegula fasciatus and Lithopoma americanum) of North America representing three different gastropod families...
March 2013: Marine Environmental Research
https://www.readbyqxmd.com/read/22266529/preparation-and-in-vitro-in-vivo-evaluation-of-sustained-release-venlafaxine-hydrochloride-pellets
#11
COMPARATIVE STUDY
Yang Liu, Yinghua Sun, Jin Sun, Nana Zhao, Mingyu Sun, Zhonggui He
The objective of this study was to prepare different venlafaxine hydrochloride sustained-release products and to elucidate the influence of composition of the coating film on the in vitro drug release profiles and in vivo pharmacokinetics. Pellets were prepared by a standardized process of extrusion/spheronization. A selected fraction size (0.8-1.0 mm diameter) of pellets of each formulation was coated with Eudragit NE30D or ethylcellulose (10 cps). Many efforts have been made to tailor drug release rate by choosing different coating materials, different percent of pore forming components and coating weight variation to achieve a desired sustained-release effect...
April 15, 2012: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/21463069/examining-the-use-of-tramadol-hydrochloride-as-an-antidepressant
#12
Justin Barber
Tramadol (Ultram, Ultracet) is a centrally acting synthetic opioid with analgesic efficacy comparable to codeine. Antinociception is attributed to low but effective affinity for the mu-opioid receptor (μ), as well as reuptake inhibition of the monoamines norepinephrine (NE) and serotonin (5HT). Dual action antidepressants mirtazapine (Remeron), duloxetine (Cymbalta), and most notably venlafaxine (Effexor), which tramadol is closely related to in structure, also inhibit NE and 5HT reuptake. These medications are proven effective antidepressants and this shared monoaminergic action resulted in the research of tramadol as a potential treatment for depression...
April 2011: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/20436760/use-of-antidepressants-expansion-beyond-depression-and-anxiety
#13
Elisa F Cascade, Amir H Kalali, Michael E Thase
We investigated antidepressant prescriptions and reasons for use. According to our data, the top 10 molecules represent approximately 95% of total antidepressant prescriptions for both primary care physicians (PCPs) and psychiatrists. The primary difference between PCPs and psychiatrists was the increased use of buproprion and tricyclics/tetracyclics by psychiatrists. The selective serotonin reuptake inhibitors (SSRIs) and other newer antidepressants such as venlafaxine (Effexor) and buproprion (Wellbutrin) are used to treat depression, anxiety, and bipolar disorders...
December 2007: Psychiatry
https://www.readbyqxmd.com/read/20038728/acupuncture-versus-venlafaxine-for-the-management-of-vasomotor-symptoms-in-patients-with-hormone-receptor-positive-breast-cancer-a-randomized-controlled-trial
#14
RANDOMIZED CONTROLLED TRIAL
Eleanor M Walker, Alba I Rodriguez, Beth Kohn, Ronald M Ball, Jan Pegg, Jeffrey R Pocock, Ramon Nunez, Ed Peterson, Susan Jakary, Robert A Levine
PURPOSE: Vasomotor symptoms are common adverse effects of antiestrogen hormone treatment in conventional breast cancer care. Hormone replacement therapy is contraindicated in patients with breast cancer. Venlafaxine (Effexor), the therapy of choice for these symptoms, has numerous adverse effects. Recent studies suggest acupuncture may be effective in reducing vasomotor symptoms in menopausal women. This randomized controlled trial tested whether acupuncture reduces vasomotor symptoms and produces fewer adverse effects than venlafaxine...
February 1, 2010: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/20022376/pollution-by-psychoactive-pharmaceuticals-in-the-rivers-of-madrid-metropolitan-area-spain
#15
Silvia González Alonso, Myriam Catalá, Raúl Romo Maroto, José Luis Rodríguez Gil, Angel Gil de Miguel, Yolanda Valcárcel
There are a number of reports in the literature which describe the occurrence of so-called emerging pollutants, such as pharmaceuticals, in surface water. Few of these studies have reported values from large cities in relatively arid areas, such as in Spain. The persistence of some pharmaceuticals to usual wastewater treatments allows their discharge into surface waters. It is increasingly evident that mental health problems are of special concern for public health since psychiatric drugs are used in large amounts...
February 2010: Environment International
https://www.readbyqxmd.com/read/20004291/-milnacipran-and-venlafaxine-at-flexible-doses-up-to-200-mg-d-in-the-outpatient-treatment-of-adults-with-moderate-to-severe-major-depressive-disorder-a-24-week-randomised-double-blind-exploratory-study
#16
RANDOMIZED CONTROLLED TRIAL
J-P Olié, D Gourion, A Montagne, M Rostin, M-F Poirier
INTRODUCTION: Serotonin (HT) and noradrenaline (NA) reuptake inhibitors (SNRIs) are commonly used as first line treatment of major depressive disorders (MDD). As compared to tricyclic antidepressants, they have proved similar efficacy and better tolerability. Milnacipran (MLN) (Ixel) and venlafaxine (VLF) (Effexor) are two SNRIs pharmacologically differing by their NA/HT ratio of potency: 1:1 and 1:30, respectively. OBJECTIVES: To investigate the efficacy and safety/tolerability of MLN and VLF administered at flexible doses (100, 150 or 200 mg/day) for 24 weeks (including 4 weeks of up-titration) in the outpatient treatment of adults with moderate-to-severe MDD...
December 2009: L'Encéphale
https://www.readbyqxmd.com/read/19653973/comparison-of-pharmacokinetic-profiles-of-brand-name-and-generic-formulations-of-citalopram-and-venlafaxine-a-crossover-study
#17
RANDOMIZED CONTROLLED TRIAL
Franck Chenu, Lisa A Batten, Gerald Zernig, Elisabeth Ladstaetter, Chantal Hébert, Pierre Blier
BACKGROUND: Generic drugs are lower-cost versions of patent-expired brand-name medications. Bioequivalence is decreed when the 90% confidence intervals for the ratios of the generic to the reference compound for the area under the curve and maximum plasma concentration (C(max)) fall within a 0.80 to 1.25 range. The aim of the present pilot study was to compare the pharmacokinetic profiles of brand-name and generic formulations of citalopram and extended-release venlafaxine. METHOD: Effexor XR/Novo-venlafaxine XR 75 mg and Celexa/Gen-citalopram 40 mg were studied in a randomized crossover design...
July 2009: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/19444618/fabrication-of-triple-layer-matrix-tablets-of-venlafaxine-hydrochloride-using-xanthan-gum
#18
Mukesh C Gohel, Shital H Bariya
The objective of present investigation was to develop venlafaxine hydrochloride-layered tablets for obtaining sustained drug release. The tablets containing venlafaxine hydrochloride 150 mg were prepared by wet granulation technique using xanthan gum in the middle layer and barrier layers. The granules and tablets were characterized. The in vitro drug dissolution study was conducted in distilled water. The tablets containing two lower strengths were also developed using the same percentage composition of the middle layer...
2009: AAPS PharmSciTech
https://www.readbyqxmd.com/read/19297297/-multidrug-intoxication
#19
E Valero, A Bousquet, M Almon, P Vest, F Ceppa, C Pelletier, C Renard
The authors report an suicide attempt by a 43 years old woman treated by Previscan, Effexor, Rivotril, and Stilnox for phlebitis anteriority and anxious-depressive disorders. On arrival to the emergency unit, the medical status and the patient history required a cardiovascular reanimation and gastric washing. The haemostasis analysis demonstrates an anticoagulant overdose and the prescription of vitamine K1 and PPSB was necessary. Later, the multidrug poisoning was demonstrated thanks to blood, urinary and gastric fluid high performance liquid chromatography toxicological analyses...
March 2009: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/19133491/understanding-the-clinical-profile-of-a-drug-on-the-basis-of-its-pharmacology-mirtazapine-as-an-example
#20
REVIEW
Robert H Howland
Direct comparisons of different drugs used for the same indication can reveal important differences in efficacy or tolerability. Such clinical differences can often be explained or predicted on the basis of the particular pharmacological properties of each drug. To demonstrate the clinical importance of understanding the distinct pharmacology of a drug, this article describes the pharmacology and clinical profile of mirtazapine (Remeron). Mirtazapine is a pharmacologically unique agent among antidepressant drugs...
December 2008: Journal of Psychosocial Nursing and Mental Health Services
keyword
keyword
9251
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"