Utkarsh Sood, Moritz Müller, Tian Lan, Gauri Garg, Nirjara Singhvi, Princy Hira, Priya Singh, Aeshna Nigam, Mansi Verma, Pushp Lata, Hardeep Kaur, Abhilash Kumar, Charu Dogra Rawat, Sukanya Lal, Courtney Aldrich, Andreas Bechthold, Rup Lal
Ever since the isolation of Amycolatopsis mediterranei in 1957, this strain has been the focus of research worldwide. In the last 60 years or more, our understanding of the taxonomy, development of cloning vectors and conjugation system, physiology, genetics, genomics, and biosynthetic pathway of rifamycin B production in A . mediterranei has substantially increased. In particular, the development of cloning vectors, transformation system, characterization of the rifamycin biosynthetic gene cluster, and the regulation of rifamycin B production by the pioneering work of Heinz Floss have made the rifamycin polyketide biosynthetic gene cluster (PKS) an attractive target for extensive genetic manipulations to produce rifamycin B analogues which could be effective against multi-drug-resistant tuberculosis...
January 30, 2024: Journal of Natural Products