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JOURNAL ARTICLE
Minesh Prakash, Varun Sharma, Timothy Oh, Casey Lo, Grant Parkinson, David McCormack, Paul Conaglen, Zaw Lin, Nand Kejriwal, Felicity Meikle, Emma Peplow, Jack Bhana, Adam El Gamel
INTRODUCTION: Cardiopulmonary bypass (CPB) machines have oxygenators with integrated filters and unique biocompatible coatings to combat systemic inflammatory response syndrome (SIRS) and mitigate coagulopathy. Contemporary oxygenators have undergone comparative studies; however, our study aimed to identify the most appropriate oxygenator for our regional Cardiothoracic unit in Australasia. METHODS: A prospective audit consecutively recruited one-hundred and fifty patients undergoing cardiac surgery at Waikato Hospital, New Zealand between the periods of 29th January 2018 and 31st July 2018...
May 5, 2022: Perfusion
#22
JOURNAL ARTICLE
Ryuichi Nakano, Akira Yamaguchi, Kayano Sunada, Takeshi Nagai, Akiyo Nakano, Yuki Suzuki, Hisakazu Yano, Hitoshi Ishiguro, Masahiro Miyauchi
Photocatalysts are promising materials for solid-state antiviral coatings to protect against the spread of pandemic coronavirus disease (COVID-19). This paper reports that copper oxide nanoclusters grafted with titanium dioxide (Cux O/TiO2 ) inactivated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, including its Delta variant, even under dark condition, and further inactivated it under illumination with a white fluorescent bulb. To investigate its inactivation mechanism, the denaturation of spike proteins of SARS-CoV-2 was examined by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and enzyme-linked immunosorbent assay (ELISA)...
April 14, 2022: Scientific Reports
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JOURNAL ARTICLE
Sean D Young, William G Cumberland, Parvati Singh, Thomas Coates, William G Cumberland
OBJECTIVE: We sought to assess the effectiveness of using a peer-led online community to increase HIV self-testing among Latinx and African American men who have sex with men (MSM). DESIGN: Randomized controlled trial. METHODS: Throughout 6 waves, between February 18, 2017 and January 8, 2021, 900 HIV negative and/or serostatus unknown Los Angeles-based MSM (68.9% Latinx, 16.0% African American, 7.4% White) participated in an online 12-week HIV prevention randomized controlled trial...
January 18, 2022: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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JOURNAL ARTICLE
Raquel Arredondo, Francesco Poggioli, Santos Martínez-Díaz, María Piera-Trilla, Raúl Torres-Claramunt, Laura Tío, Joan C Monllau
INTRODUCTION: Partial meniscectomy is one of the most common surgical strategy for a meniscal injury, but sometimes, patients complain of knee pain due to an overload in the ablated compartment. In these cases, implantation of tissue engineering scaffold could be indicated. Currently, two commercial scaffolds, based on collagen or polycaprolactone-polyurethane (PCL-PU), are available for meniscus scaffolding. In short term follow-up assessments, both showed clinical improvement and tissue formation...
December 2021: Regenerative Therapy
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JOURNAL ARTICLE
Derya Tepe, Songül Yılmaz
Background: Although it is not reflected in the OBP measurement in obese children, ambulatory BP changes are known to occur. MH, non-dipper pattern and nocturnal hypertension have been reported to increase in obese children. On the other hand, the factors that indicate a high risk of hypertension are still unclear. The aim of our study is to especially detect masked hypertension by 24-hour BP measurement in obese adolescents and to evaluate the relationship of masked hypertension with metabolic syndrome parameters, anthropometric measurements and hepatosteatosis in these patients...
2021: Diabetes, Metabolic Syndrome and Obesity
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REVIEW
Eliseo Picchi, Valentina Ferrazzoli, Giulia Pizzicannella, Noemi Pucci, Francesca Pitocchi, Fabrizio Valente, Silvia Minosse, Francesca Izzi, Tommaso Schirinzi, Chiara Bonomi, Chiara Aiello, Roberto Floris, Francesco Garaci, Francesca Di Giuliano
Leukoencephalopathy with cerebral calcifications and cysts (LCC) is a neurological disorder characterized by the radiological triad of white matter abnormalities, intracranial calcifications and cystic lesions variable in size resulting from a diffuse cerebral microangiopathy. Typically, progressive focal neurological deficits and seizures are the first clinical manifestation, but the severity of symptoms can vary according to the size and location of the cystic lesions holding compressive effects on the surrounding brain tissue...
November 2021: Neurological Sciences
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JOURNAL ARTICLE
Shay Keren, Michael Waisbourd, Nir Gomel, Yael Cohen, Shimon Kurtz
PURPOSE: To investigate the effects of mental stress stimulus on intraocular pressure (IOP) measurement and visual field (VF) testing. METHODS: Patients with open angle glaucoma underwent a baseline IOP measurement and VF testing. Afterwards, they completed a computerized mental stress test (Stroop test) which is a known standardized method to induce mental stress. After test completion, patients underwent a second IOP measurement and VF testing. RESULTS: Seventy-two eyes of 36 patients were enrolled...
January 2022: Graefe's Archive for Clinical and Experimental Ophthalmology
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JOURNAL ARTICLE
Xing-Jiang Xiong
Huanglian Ejiao Decoction,firstly recorded in Treatise on Febrile Diseases,could be used to treat heat-conversion syndrome of Shaoyin. It has been identified that,the indications of Huanglian Ejiao Decoction include:(1)in modern medicine,it can be used to treat insomnia,arrhythmia,oral ulcer,Xiali,blood syndrome and other diseases;(2)in terms of symptoms and signs,it is mainly used for restlessness,ritability,insomnia,extremely difficult to fall asleep,palpitation,atrial premature beat,ventricular premature beat and other arrhythmias,stomach distension and stuffiness,stomach pain,vomiting,abdominal pain,cramps,lower edge,constipation,blush,red lips,easy bleeding,red tongue,thin or no coating,dry tongue surface,or light red tongue,or dark red,thin white tongue coating,and rapid pulse...
July 2021: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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JOURNAL ARTICLE
Ziad Abdullah Taher, Waleed W Khayyat, Marwan M Balubaid, Mohamed Y Tashkandi, Saeed M Alamoudi, Abdulhalim Jamal Kinsara
Background: Accumulating evidence demonstrates that white-coat hypertension (WCH) are associated with several risks and complications. In this study, we aimed to investigate the adverse effects of WCH compared with hypertensive and normotensive patients. Methods: A retrospective cohort study was conducted over five years. Blood pressure (BP) data was collected from both clinic visits and 24-h ambulatory blood pressure monitoring (ABPM) reports. Epidemiological data and complications, cardiac and noncardiac, were also recorded...
January 2021: Heart Views: the Official Journal of the Gulf Heart Association
#30
JOURNAL ARTICLE
Tomáš Seeman, Friederike Weigel, Kveta Blahova, Filip Fencl, Stepanka Pruhova, Katharina Hermes, Richard Klaus, Bärbel Lange-Sperandio, Veit Grote, Ulrike John-Kroegel
Cystic kidney diseases such as autosomal recessive or dominant polycystic kidney disease (ARPKD and ADPKD) are associated with high prevalence of arterial hypertension. On the contrary, studies on hypertension in children with renal cysts and diabetes (RCAD) syndrome caused by abnormalities in the HNF1B gene are rare. Therefore, the primary aim of our study was to investigate the prevalence of high blood pressure in children with RCAD syndrome due to HNF1B gene abnormalities and secondary to search for possible risk factors for development of high blood pressure...
June 26, 2021: European Journal of Pediatrics
#31
JOURNAL ARTICLE
Liu Mange, Ren Haitao, Zhou Lixin, Fan Siyuan, Wang Jing, Guan Hongzhi
BACKGROUND: AP3B2 is one of the subunits of vesicle coat protein AP3 and is specifically expressed in central nervous system neurons. AP3B2 antibody has been reported in patients with autoimmune cerebellar ataxia and various extracerebellar symptoms. However, there have been few reports on its clinical features and treatment response. METHODS: We report a 47-year-old man with AP3B2 antibody who presented with insidious-onset paresthesia and gait disturbance. His serum and cerebrospinal fluid (CSF) showed reactivity with the cytoplasm of Purkinje cells and granular layer synapses comparable to the reported specific pattern of anti-AP3B2 IgG, and this was confirmed by a cell-based assay...
May 14, 2021: Journal of Neurology
#32
JOURNAL ARTICLE
Agostino Accardo, Lorenzo Pascazio, Fulvia Costantinides, Fabio Gorza, Giulia Silveri
BACKGROUND: Sublingual varices (SV) are dilatations of tortuous veins that increased with age. Previous studies showed that this pathology could be correlated to some risk factors such as hypertension, age, gender and diabetes mellitus. In this study we evaluated, on a large number of subjects, the relationship between SV and different grades of hypertension as well as some risk factors extending the analysis to new risk factors such as dyslipidemia, obesity and antihypertensive therapy, modelling a possible dependence of SV on all these factors...
May 4, 2021: BMC Oral Health
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JOURNAL ARTICLE
Yuuki Moriyasu, Chiho Fukumoto, Maki Wada, Erika Yano, Hiroshi Murase, Masatoshi Mizuno, Nobuhiro Zaima, Tatsuya Moriyama
In this study, we fed obese model mice black soybean seed coat powder (BSCP) and evaluated the antiobesity effects. As a control, normal yellow soybean seed coat powder (YSCP) was used. C57BL/6J, a high-fat diet-induced obesity model mouse, was fed a high-fat diet containing BSCP or YSCP (20% fat) to induce obesity. The results showed that in the BSCP group, it caused significant suppression of body weight gain and suppression of white adipose tissue weight compared with the YSCP group. Moreover, it significantly decreased serum leptin levels, which correlated with visceral fat mass, and increased antidiabetic adipocytokine and adiponectin levels...
April 13, 2021: Foods (Basel, Switzerland)
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JOURNAL ARTICLE
Vaskar Thapa, Gregory G Turner, Marilyn J Roossinck
Understanding the dynamics of white-nose syndrome spread in time and space is an important component for the disease epidemiology and control. We reported earlier that a novel partitivirus, Pseudogymnoascus destructans partitivirus-pa, had infected the North American isolates of Pseudogymnoascus destructans, the fungal pathogen that causes white-nose syndrome in bats. We showed that the diversity of the viral coat protein sequences is correlated to their geographical origin. Here we hypothesize that the geographical adaptation of the virus could be used as a proxy to characterize the spread of white-nose syndrome...
March 2021: PLoS Pathogens
#35
REVIEW
Jian-Feng Huang, Yan Li, Jinho Shin, Yook-Chin Chia, Apichard Sukonthasarn, Yuda Turana, Chen-Huan Chen, Hao-Min Cheng, Arieska Ann Soenarta, Jam Chin Tay, Tzung-Dau Wang, Kazuomi Kario, Ji-Guang Wang
Asian countries are facing an increasing prevalence of metabolic syndrome (MetS), which may aggravate the burden of cardiovascular diseases in this region. MetS is closely associated with ambulatory blood pressure (BP). Patients with MetS, compared to those without, had a twofold higher risk of new-onset office, home, or ambulatory hypertension. Furthermore, the risk of new-onset MetS in patients with white-coat, masked and sustained hypertension was also doubled compared to normotensives. High-risk masked hypertension and blunted nighttime BP dipping are common in patients with MetS, suggesting perfect 24-hour BP control with long-acting antihypertensive drugs and early initiation of combination therapy might be especially important for patients with MetS...
February 25, 2021: Journal of Clinical Hypertension
#36
MULTICENTER STUDY
Leora R Feldstein, Mark W Tenforde, Kevin G Friedman, Margaret Newhams, Erica Billig Rose, Heda Dapul, Vijaya L Soma, Aline B Maddux, Peter M Mourani, Cindy Bowens, Mia Maamari, Mark W Hall, Becky J Riggs, John S Giuliano, Aalok R Singh, Simon Li, Michele Kong, Jennifer E Schuster, Gwenn E McLaughlin, Stephanie P Schwartz, Tracie C Walker, Laura L Loftis, Charlotte V Hobbs, Natasha B Halasa, Sule Doymaz, Christopher J Babbitt, Janet R Hume, Shira J Gertz, Katherine Irby, Katharine N Clouser, Natalie Z Cvijanovich, Tamara T Bradford, Lincoln S Smith, Sabrina M Heidemann, Sheemon P Zackai, Kari Wellnitz, Ryan A Nofziger, Steven M Horwitz, Ryan W Carroll, Courtney M Rowan, Keiko M Tarquinio, Elizabeth H Mack, Julie C Fitzgerald, Bria M Coates, Ashley M Jackson, Cameron C Young, Mary Beth F Son, Manish M Patel, Jane W Newburger, Adrienne G Randolph
IMPORTANCE: Refinement of criteria for multisystem inflammatory syndrome in children (MIS-C) may inform efforts to improve health outcomes. OBJECTIVE: To compare clinical characteristics and outcomes of children and adolescents with MIS-C vs those with severe coronavirus disease 2019 (COVID-19). SETTING, DESIGN, AND PARTICIPANTS: Case series of 1116 patients aged younger than 21 years hospitalized between March 15 and October 31, 2020, at 66 US hospitals in 31 states...
March 16, 2021: JAMA
#37
M Hauser, S Wolf-Hofstetter, F Acklin-Menzi, E Studer, D Rediger, F Seefried, C Drögemüller
Occasionally black-and-white spotted calves appear in Switzerland, which show a special fur only in the pigmented area. Otherwise these animals are normally developed. The white hairs are normal, but they appear relatively long and smooth, because the pigmented hairs are curly and thus appear shortened. In addition, the affected animals show a variable intensity of coat colour in the pigmented area. At birth affected calves often appear black, whereas older cattle show bright colours from reddish brown to grey...
September 2020: Schweizer Archiv Für Tierheilkunde
#38
JOURNAL ARTICLE
Ahsan Ashfaq, Shehzeen F Memon, Ayesha Zehra, Samrana Barry, Huzema Jawed, Maryam Akhtar, Wajeeha Kirmani, Faaiz Malik, Adina W Khawaja, Hamama Barry, Hadi Saiyid, Nimra Farooqui, Shazra Khalid, Komal Abbasi, Rabbia Siddiqi
Background Telemedicine is an affordable use of information and communication technology (ICT) to enable long-distance patient care and health care services. While the developed world continues to take advantage of this technology, its concept remains new to Pakistan. This study aims to assess the knowledge and perceptions regarding telemedicine among health care professionals in Karachi, Pakistan. Methods This cross-sectional study was carried out among doctors employed in the public health sector in Karachi from June 2018 to August 2018...
February 9, 2020: Curēus
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JOURNAL ARTICLE
Thapanan Jatuyosporn, Pasunee Laohawutthichai, Premruethai Supungul, Rogerio R Sotelo-Mundo, Adrian Ochoa-Leyva, Anchalee Tassanakajon, Kuakarun Krusong
White spot syndrome virus (WSSV) is one of the most lethal viruses severely affecting shrimp industry. This disease can cause 100% mortality of farmed shrimp within a week. This work aims to characterize clathrin assembly proteins in Penaeus monodon and investigate their roles in WSSV entry. In general, clathrin assembly proteins form complexes with specific receptors and clathrins, leading to clathrin-mediated endocytosis. Adaptor protein 2 (AP-2), which is responsible for endocytosis at plasma membrane, consists of four subunits including α, β2, μ2 and σ2...
September 17, 2019: Scientific Reports
#40
JOURNAL ARTICLE
Laura C Armitage, Maxine E Whelan, Peter J Watkinson, Andrew J Farmer
Hypertension is the leading risk factor for death globally. A significant percentage of patients admitted to hospital have undiagnosed hypertension, yet recognition of elevated blood pressure (BP) in hospital and referral for post-discharge assessment are poor. Physician perception that elevated inhospital BP is attributable to anxiety, pain, or white coat syndrome may underlie an expectation that BP will normalize following discharge. However, these patients frequently remain hypertensive. The authors conducted a systematic review to evaluate the extent to which elevated inhospital BP can predict the presence of hypertension in previously undiagnosed adults...
September 2019: Journal of Clinical Hypertension
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