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https://www.readbyqxmd.com/read/28951305/delivery-of-viral-recombinant-vp28-protein-using-chitosan-tripolyphosphate-nanoparticles-to-protect-the-whiteleg-shrimp-litopenaeus-vannamei-from-white-spot-syndrome-virus-infection
#1
G Taju, D Vinoth Kumar, S Abdul Majeed, S Vimal, S Tamizhvanan, S Santhosh Kumar, S Sivakumar, A Nazeer Basha, P Haribabu, K Kannabiran, A S Sahul Hameed
The VP28 gene of white spot syndrome virus was amplified by PCR using gene specific primer set and cloned into pRSET B vector to produce recombinant VP28 (r-VP28) in E. coli GJ1158. The chitosan tripolyphosphate nanoparticles (CS/TPP) were prepared by ionic gelation process and characterized. The purified r-VP28 protein was encapsulated by CS/TPP nanoparticles. The encapsulation efficiency of CS/TPP nanoparticles was found to be 84.8% for r-VP28 protein binding with CS/TPP nanoparticles. The in vitro release profile of encapsulated r-VP28 was determined after treating with protease and chitosanase...
September 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28670638/a-comparison-of-rapid-diagnostic-testing-by-plasmodium-lactate-dehydrogenase-and-quantitative-buffy-coat-technique-in-malaria-diagnosis-in-children
#2
Ifeanyi Kanayo Ifeorah, Biobele J Brown, Olugbemiro O Sodeinde
BACKGROUND: The World Health Organization (WHO) considers early and rapid diagnosis as one of the strategies to control malaria. This study compared the performance of Quantitative Buffy Coat (QBC) test and the Plasmodium lactate dehydrogenase (pLDH) rapid diagnostic test (RDT) with microscopy as the gold standard. MATERIALS AND METHODS: The study involved children ages 0-5 years who presented with a history of fever at the University College Hospital, Ibadan, Nigeria...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28527475/the-oximapa-study-hypertension-control-by-abpm-and-association-with-sleep-apnea-syndrome-by-pulse-oximetry
#3
Tiago Maricoto, Eurico Alves Rodrigues Silva, Pedro Damião, José Mesquita Bastos
INTRODUCTION: Ambulatory blood pressure monitoring by automatic device is the best blood pressure evaluation method and sleep apnea syndrome is the leading cause of poor control. Oximetry allows screening these individuals but its usefulness has been poorly explored in Primary Health Care. The aim was to evaluate the blood pressure control at the office and with ambulatory blood pressure monitoring by automatic device and to relate it to sleep apnea syndrome. MATERIAL AND METHODS: We selected a sample of 50 participants, representative of 3036 hypertensive patients...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28483823/patient-use-of-blood-pressure-self-screening-facilities-in-general-practice-waiting-rooms-a-qualitative-study-in-the-uk
#4
Alice C Tompson, Sabrina Grant, Sheila M Greenfield, Richard J McManus, Susannah Fleming, Carl J Heneghan, Fd Richard Hobbs, Alison M Ward
BACKGROUND: Blood pressure (BP) self-screening, whereby members of the public have access to BP monitoring equipment outside of healthcare consultations, may increase the detection and treatment of hypertension. Currently in the UK such opportunities are largely confined to GP waiting rooms. AIM: To investigate the reasons why people do or do not use BP self-screening facilities. DESIGN AND SETTING: A cross-sectional, qualitative study in Oxfordshire, UK...
July 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28027325/using-a-novel-partitivirus-in-pseudogymnoascus-destructans-to-understand-the-epidemiology-of-white-nose-syndrome
#5
Vaskar Thapa, Gregory G Turner, Susan Hafenstein, Barrie E Overton, Karen J Vanderwolf, Marilyn J Roossinck
White-nose syndrome is one of the most lethal wildlife diseases, killing over 5 million North American bats since it was first reported in 2006. The causal agent of the disease is a psychrophilic filamentous fungus, Pseudogymnoascus destructans. The fungus is widely distributed in North America and Europe and has recently been found in some parts of Asia, but interestingly, no mass mortality is observed in European or Asian bats. Here we report a novel double-stranded RNA virus found in North American isolates of the fungus and show that the virus can be used as a tool to study the epidemiology of White-nose syndrome...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27992657/protection-of-penaeus-monodon-against-white-spot-syndrome-by-continuous-oral-administration-of-a-low-concentration-of-bacillus-subtilis-spores-expressing-the-vp28-antigen
#6
K-C Pham, H T T Tran, C Van Doan, P H Le, A T Van Nguyen, H A Nguyen, H A Hong, S M Cutting, T-N Phan
In this study, Bacillus subtilis spores expressing a chimeric protein, CotB-VP28, were used as a probiotic vaccine to protect black tiger shrimps (Penaeus monodon) against white spot syndrome virus (WSSV) infection. Oral administration of pellets coated with CotB-VP28 spores (at ≥1 × 10(9 ) CFU per g pellet) to shrimps induced immune-relating phenoloxydase activity (PO) in shrimps after 14 days of feeding (prior challenge) and at day 3 post challenge (1·26 and 1·70 fold increase respectively). A 75% protection rate was obtained by continuous feeding of the spore-coated pellets at ≥1 × 10(9 ) CFU per g for 14 days prior to WSSV challenge and during all the postchallenge period...
March 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/27918999/effect-of-silver-nanoparticles-on-the-metabolic-rate-hematological-response-and-survival-of-juvenile-white-shrimp-litopenaeus-vannamei
#7
Karla Juarez-Moreno, Claudio Humberto Mejía-Ruiz, Fernando Díaz, Horacio Reyna-Verdugo, Ana Denisse Re, Edgar F Vazquez-Felix, Edna Sánchez-Castrejón, Josué D Mota-Morales, Alexey Pestryakov, Nina Bogdanchikova
White spot syndrome virus (WSSV) is highly lethal and contagious in shrimps; its outbreaks causes an economic crisis for aquaculture. Several attempts have been made to treat this disease; however, to date, there is no effective cure. Because of their antimicrobial activities, silver nanoparticles (AgNPs) are the most studied nanomaterial. Although the antiviral properties of AgNPs have been studied, their antiviral effect against viral infection in aquaculture has not been reported. The AgNPs tested herein are coated with polyvinylpyrrolidone (PVP) and possess multiple international certifications for their use in veterinary and human applications...
February 2017: Chemosphere
https://www.readbyqxmd.com/read/27694622/the-%C3%AE-isoform-of-bccip-promotes-adp-release-from-the-rad51-presynaptic-filament-and-enhances-homologous-dna-pairing
#8
Andrew A Kelso, Steven D Goodson, Leah E Watts, LeAnna L Ledford, Sarah M Waldvogel, J Nathaniel Diehl, Shivani B Shah, Amanda F Say, Julie D White, Michael G Sehorn
Homologous recombination (HR) is a template-driven repair pathway that mends DNA double-stranded breaks (DSBs), and thus helps to maintain genome stability. The RAD51 recombinase facilitates DNA joint formation during HR, but to accomplish this task, RAD51 must be loaded onto the single-stranded DNA. DSS1, a candidate gene for split hand/split foot syndrome, provides the ability to recognize RPA-coated ssDNA to the tumor suppressor BRCA2, which is complexed with RAD51. Together BRCA2-DSS1 displace RPA and load RAD51 onto the ssDNA...
January 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27538980/ambulatory-blood-pressure-monitoring-in-frequently-relapsing-nephrotic-syndrome
#9
Subhankar Sarkar, Aditi Sinha, Ramakrishnan Lakshmy, Anuja Agarwala, Anita Saxena, Pankaj Hari, Arvind Bagga
OBJECTIVES: To screen patients with frequently relapsing nephrotic syndrome (FRNS) for the presence of ambulatory hypertension and left ventricular hypertrophy. METHODS: Following ethical and parental approvals, consecutive patients with FRNS of ≥2 y duration were enrolled. Those with estimated glomerular filtration rate <60 ml/min/1.73 m(2) and known familial hypercholesterolemia or diabetes mellitus were excluded. Clinic blood pressure was measured by oscillometry and 24-h ambulatory blood pressure was recorded by Spacelab 90207; echocardiography was done for left ventricular mass...
January 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27529988/from-single-nucleotide-substitutions-up-to-chromosomal-deletions-genetic-pause-of-leucism-associated-disorders-in-animals
#10
REVIEW
Katharina Fleck, Georg Erhardt, Gesine Lühken
Leucism is characterized by a complete or partial white skin and hair in combination with pigmented irides, which can be vivid blue or heterochromatic. This is due to a complete or partial lack of melanocytes. The underlying pathogenesis is a disturbed emigration or differentiation of neural crest-derived cells. Therefore, leucistic phenotypes can be associated with defects, which mainly impair sensory organs and nerves. In humans, a well-known example is the Waardenburg syndrome. Leucism-associated disorders were also described in mouse, rat, hamster, rabbit, mink, cat, dog, pig, sheep, llama, alpaca, cattle and horse...
July 2016: Berliner und Münchener Tierärztliche Wochenschrift
https://www.readbyqxmd.com/read/27429675/white-coat-hyperglycemia-the-forgotten-syndrome
#11
Jamila Abdedaim Benmoussa, Matthew Clarke, Dennis Bloomfield
No abstract text is available yet for this article.
August 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27313640/traditional-chinese-medicine-for-metabolic-syndrome-via-tcm-pattern-differentiation-tongue-diagnosis-for-predictor
#12
Tsung-Chieh Lee, Lun-Chien Lo, Fang-Chen Wu
Metabolic syndrome is a morbid condition, which is manifested by central obesity, abnormal glucose tolerance, lipodystrophy, and hypertension. Traditional Chinese medicine (TCM) clarifies that obesity is classified as phlegm-dampness. It is often accompanied with qi stagnation and blood stasis. One hundred and two overweight adults, who did not receive lipid-lowering drugs, were enrolled for analysis. The exclusion criteria were adults having malignancy disease, DM, and renal disease or who were pregnant or lactating...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27241285/injected-phage-displayed-vp28-vaccine-reduces-shrimp-litopenaeus-vannamei-mortality-by-white-spot-syndrome-virus-infection
#13
G Solís-Lucero, K Manoutcharian, J Hernández-López, F Ascencio
White spot syndrome virus (WSSV) is the most important viral pathogen for the global shrimp industry causing mass mortalities with huge economic losses. Recombinant phages are capable of expressing foreign peptides on viral coat surface and act as antigenic peptide carriers bearing a phage-displayed vaccine. In this study, the full-length VP28 protein of WSSV, widely known as potential vaccine against infection in shrimp, was successfully cloned and expressed on M13 filamentous phage. The functionality and efficacy of this vaccine immunogen was demonstrated through immunoassay and in vivo challenge studies...
August 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27039359/new-test-for-endothelin-receptor-type-b-ednrb-mutation-genotyping-in-horses
#14
Miguel Angel Ayala-Valdovinos, Jorge Galindo-García, David Sánchez-Chiprés, Theodor Duifhuis-Rivera
Lethal white foal syndrome (LWFS) is an autosomal recessive disease of neonatal foals characterized by a white hair coat and a functional intestinal obstruction. Traditional techniques for identifying the dinucleotide mutation (TC→AG) of the endothelin receptor B gene (EDNRB) associated with LWFS are time-consuming. We developed a new technique based on mutagenically separated polymerase chain reaction (MS-PCR) for simple detection of the EDNRB genotype in horses.
June 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27027721/toluene-disruption-of-the-functions-of-l1-cell-adhesion-molecule-at-concentrations-associated-with-occupational-exposures
#15
Kimberly M R White, Julia A Sabatino, Min He, Natalie Davis, Ningfeng Tang, Cynthia F Bearer
BACKGROUND: Prenatal toluene exposure can cause neurodevelopmental disabilities similar to fetal alcohol syndrome. Both share neuroanatomic pathologies similar to children with mutations in L1 cell adhesion molecule (L1). L1 mediates neurite outgrowth (NOG) via signaling through ERK1/2, which require trafficking of L1 through lipid rafts. Our objective is to determine if toluene inhibits L1-mediated NOG and toluene inhibits L1 signaling at concentrations achieved during occupational exposure...
July 2016: Pediatric Research
https://www.readbyqxmd.com/read/26988289/litopenaeus-vannamei-clathrin-coat-ap17-involved-in-white-spot-syndrome-virus-infection
#16
Xiu-Fang Wang, Qing-Hui Liu, Yin Wu, Jie Huang
White spot syndrome virus (WSSV) is the main pathogen of shrimp culture, and has brought great losses of the shrimp aquaculture industry every year since it has been found. However, the specific mechanism of the virus into the cell is not very clear. Recent research suggests that clathrin-mediated endocytosis is involved in WSSV infection. By sequence analysis, clathrin coat AP17 is an σ subunit of AP-2 complex which is involved in clathrin-mediated endocytosis. To obtain the full-length sequence of Clathrin coat AP17 of Litopenaeus vannamei (LvCCAP17), the rapid amplification of cDNA ends (RACE) was performed to get the sequence of 3'and 5' end and splicing by DNAMAN...
May 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26753319/-spina-bifida-aperta-in-a-sheep-lamb
#17
N Gutzwiller, M Hilbe, P Kircher, U Bleull
The case report describes the symptoms and diagnostic methods of a spina bifida aperta in a new born lamb. The most relevant clinical findings were recumbency immediately after birth with normal consciousness and suckling reflexes, alterations of the skin and coat in the lumbosacral region as well as dysuria. The biochemical and haematological screening of the blood indicated no abnormalities. While the radiological examination of the spine showed no clear evidence of the cause of the clinical sings the ultrasound and computed tomography examination revealed an incomplete closure of the vertebral arch between the 4th lumbar and the 3rd sacral vertebrae...
January 2015: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/26673994/-a-case-of-delayed-dia-gnosis-of-acral-lentiginous-melanoma
#18
M Gottvaldová, H Jedličková, A Poprach, V Vašků
BACKGROUND: Melanoma is a malignant skin disease. The tumor development is caused by an uncontrollable proliferation of melanocytes. The most common occurrence is on the skin, but melanoma may also develop on the mucous membrane, meninges, and eyes. Some melanomas develop from melanocytic nevus. Acral lentiginous melanoma occurs on palms, feet, fingers and under nails, and is the most common type of melanoma for phototype VI. The most important factor for successful treatment of malignant melanoma is an early detection, excision of the primary tumor and histological staging...
2015: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/26397221/white-spot-syndrome-virus-enters-crayfish-hematopoietic-tissue-cells-via-clathrin-mediated-endocytosis
#19
Jiajun Huang, Fang Li, Junjun Wu, Feng Yang
White spot syndrome virus (WSSV) is a major pathogen of aquacultured shrimp. However, the mechanism of its entry remains poorly understood. In this study, by analyzing the internalization of WSSV using crayfish hematopoietic tissue (HPT) cells, we showed that WSSV virions were engulfed by cell membrane invaginations sharing the features of clathrin-coated pits and then internalized into coated cytoplasmic vesicles. Further investigation indicated that WSSV internalization was significantly inhibited by chlorpromazine (CPZ) but not genistein...
December 2015: Virology
https://www.readbyqxmd.com/read/26380977/a-novel-detection-platform-for-shrimp-white-spot-syndrome-virus-using-an-icp11-dependent-immunomagnetic-reduction-imr-assay
#20
Bing-Hsien Liu, Yu-Chen Lin, Chia-Shin Ho, Che-Chuan Yang, Yun-Tsui Chang, Jui-Feng Chang, Chun-Yuan Li, Cheng-Shun Cheng, Jiun-Yan Huang, Yen-Fu Lee, Ming-Hung Hsu, Feng-Chun Lin, Hao-Ching Wang, Chu-Fang Lo, Shieh-Yueh Yang, Han-Ching Wang
Shrimp white spot disease (WSD), which is caused by white spot syndrome virus (WSSV), is one of the world's most serious shrimp diseases. Our objective in this study was to use an immunomagnetic reduction (IMR) assay to develop a highly sensitive, automatic WSSV detection platform targeted against ICP11 (the most highly expressed WSSV protein). After characterizing the magnetic reagents (Fe3O4 magnetic nanoparticles coated with anti ICP11), the detection limit for ICP11 protein using IMR was approximately 2 x 10(-3) ng/ml, and the linear dynamic range of the assay was 0...
2015: PloS One
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