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White coat syndrome

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https://www.readbyqxmd.com/read/27694622/the-%C3%AE-isoform-of-bccip-promotes-adp-release-from-the-rad51-presynaptic-filament-and-enhances-homologous-dna-pairing
#1
Andrew A Kelso, Steven D Goodson, Leah E Watts, LeAnna L Ledford, Sarah M Waldvogel, J Nathaniel Diehl, Shivani B Shah, Amanda F Say, Julie D White, Michael G Sehorn
Homologous recombination (HR) is a template-driven repair pathway that mends DNA double-stranded breaks (DSBs), and thus helps to maintain genome stability. The RAD51 recombinase facilitates DNA joint formation during HR, but to accomplish this task, RAD51 must be loaded onto the single-stranded DNA. DSS1, a candidate gene for split hand/split foot syndrome, provides the ability to recognize RPA-coated ssDNA to the tumor suppressor BRCA2, which is complexed with RAD51. Together BRCA2-DSS1 displace RPA and load RAD51 onto the ssDNA...
September 30, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27538980/ambulatory-blood-pressure-monitoring-in-frequently-relapsing-nephrotic-syndrome
#2
Subhankar Sarkar, Aditi Sinha, Ramakrishnan Lakshmy, Anuja Agarwala, Anita Saxena, Pankaj Hari, Arvind Bagga
OBJECTIVES: To screen patients with frequently relapsing nephrotic syndrome (FRNS) for the presence of ambulatory hypertension and left ventricular hypertrophy. METHODS: Following ethical and parental approvals, consecutive patients with FRNS of ≥2 y duration were enrolled. Those with estimated glomerular filtration rate <60 ml/min/1.73 m(2) and known familial hypercholesterolemia or diabetes mellitus were excluded. Clinic blood pressure was measured by oscillometry and 24-h ambulatory blood pressure was recorded by Spacelab 90207; echocardiography was done for left ventricular mass...
August 19, 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/27529988/from-single-nucleotide-substitutions-up-to-chromosomal-deletions-genetic-pause-of-leucism-associated-disorders-in-animals
#3
REVIEW
Katharina Fleck, Georg Erhardt, Gesine Lühken
Leucism is characterized by a complete or partial white skin and hair in combination with pigmented irides, which can be vivid blue or heterochromatic. This is due to a complete or partial lack of melanocytes. The underlying pathogenesis is a disturbed emigration or differentiation of neural crest-derived cells. Therefore, leucistic phenotypes can be associated with defects, which mainly impair sensory organs and nerves. In humans, a well-known example is the Waardenburg syndrome. Leucism-associated disorders were also described in mouse, rat, hamster, rabbit, mink, cat, dog, pig, sheep, llama, alpaca, cattle and horse...
July 2016: Berliner und Münchener Tierärztliche Wochenschrift
https://www.readbyqxmd.com/read/27429675/white-coat-hyperglycemia-the-forgotten-syndrome
#4
Jamila Abdedaim Benmoussa, Matthew Clarke, Dennis Bloomfield
No abstract text is available yet for this article.
August 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27313640/traditional-chinese-medicine-for-metabolic-syndrome-via-tcm-pattern-differentiation-tongue-diagnosis-for-predictor
#5
Tsung-Chieh Lee, Lun-Chien Lo, Fang-Chen Wu
Metabolic syndrome is a morbid condition, which is manifested by central obesity, abnormal glucose tolerance, lipodystrophy, and hypertension. Traditional Chinese medicine (TCM) clarifies that obesity is classified as phlegm-dampness. It is often accompanied with qi stagnation and blood stasis. One hundred and two overweight adults, who did not receive lipid-lowering drugs, were enrolled for analysis. The exclusion criteria were adults having malignancy disease, DM, and renal disease or who were pregnant or lactating...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27241285/injected-phage-displayed-vp28-vaccine-reduces-shrimp-litopenaeus-vannamei-mortality-by-white-spot-syndrome-virus-infection
#6
G Solís-Lucero, K Manoutcharian, J Hernández-López, F Ascencio
White spot syndrome virus (WSSV) is the most important viral pathogen for the global shrimp industry causing mass mortalities with huge economic losses. Recombinant phages are capable of expressing foreign peptides on viral coat surface and act as antigenic peptide carriers bearing a phage-displayed vaccine. In this study, the full-length VP28 protein of WSSV, widely known as potential vaccine against infection in shrimp, was successfully cloned and expressed on M13 filamentous phage. The functionality and efficacy of this vaccine immunogen was demonstrated through immunoassay and in vivo challenge studies...
August 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27039359/new-test-for-endothelin-receptor-type-b-ednrb-mutation-genotyping-in-horses
#7
Miguel Angel Ayala-Valdovinos, Jorge Galindo-García, David Sánchez-Chiprés, Theodor Duifhuis-Rivera
Lethal white foal syndrome (LWFS) is an autosomal recessive disease of neonatal foals characterized by a white hair coat and a functional intestinal obstruction. Traditional techniques for identifying the dinucleotide mutation (TC→AG) of the endothelin receptor B gene (EDNRB) associated with LWFS are time-consuming. We developed a new technique based on mutagenically separated polymerase chain reaction (MS-PCR) for simple detection of the EDNRB genotype in horses.
June 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27027721/toluene-disruption-of-the-functions-of-l1-cell-adhesion-molecule-at-concentrations-associated-with-occupational-exposures
#8
Kimberly M R White, Julia A Sabatino, Min He, Natalie Davis, Ningfeng Tang, Cynthia F Bearer
BACKGROUND: Prenatal toluene exposure can cause neurodevelopmental disabilities similar to fetal alcohol syndrome. Both share neuroanatomic pathologies similar to children with mutations in L1 cell adhesion molecule (L1). L1 mediates neurite outgrowth (NOG) via signaling through ERK1/2, which require trafficking of L1 through lipid rafts. Our objective is to determine if toluene inhibits L1-mediated NOG and toluene inhibits L1 signaling at concentrations achieved during occupational exposure...
July 2016: Pediatric Research
https://www.readbyqxmd.com/read/26988289/litopenaeus-vannamei-clathrin-coat-ap17-involved-in-white-spot-syndrome-virus-infection
#9
Xiu-Fang Wang, Qing-Hui Liu, Yin Wu, Jie Huang
White spot syndrome virus (WSSV) is the main pathogen of shrimp culture, and has brought great losses of the shrimp aquaculture industry every year since it has been found. However, the specific mechanism of the virus into the cell is not very clear. Recent research suggests that clathrin-mediated endocytosis is involved in WSSV infection. By sequence analysis, clathrin coat AP17 is an σ subunit of AP-2 complex which is involved in clathrin-mediated endocytosis. To obtain the full-length sequence of Clathrin coat AP17 of Litopenaeus vannamei (LvCCAP17), the rapid amplification of cDNA ends (RACE) was performed to get the sequence of 3'and 5' end and splicing by DNAMAN...
May 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/26753319/-spina-bifida-aperta-in-a-sheep-lamb
#10
N Gutzwiller, M Hilbe, P Kircher, U Bleull
The case report describes the symptoms and diagnostic methods of a spina bifida aperta in a new born lamb. The most relevant clinical findings were recumbency immediately after birth with normal consciousness and suckling reflexes, alterations of the skin and coat in the lumbosacral region as well as dysuria. The biochemical and haematological screening of the blood indicated no abnormalities. While the radiological examination of the spine showed no clear evidence of the cause of the clinical sings the ultrasound and computed tomography examination revealed an incomplete closure of the vertebral arch between the 4th lumbar and the 3rd sacral vertebrae...
January 2015: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/26673994/-a-case-of-delayed-dia-gnosis-of-acral-lentiginous-melanoma
#11
M Gottvaldová, H Jedličková, A Poprach, V Vašků
BACKGROUND: Melanoma is a malignant skin disease. The tumor development is caused by an uncontrollable proliferation of melanocytes. The most common occurrence is on the skin, but melanoma may also develop on the mucous membrane, meninges, and eyes. Some melanomas develop from melanocytic nevus. Acral lentiginous melanoma occurs on palms, feet, fingers and under nails, and is the most common type of melanoma for phototype VI. The most important factor for successful treatment of malignant melanoma is an early detection, excision of the primary tumor and histological staging...
2015: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/26397221/white-spot-syndrome-virus-enters-crayfish-hematopoietic-tissue-cells-via-clathrin-mediated-endocytosis
#12
Jiajun Huang, Fang Li, Junjun Wu, Feng Yang
White spot syndrome virus (WSSV) is a major pathogen of aquacultured shrimp. However, the mechanism of its entry remains poorly understood. In this study, by analyzing the internalization of WSSV using crayfish hematopoietic tissue (HPT) cells, we showed that WSSV virions were engulfed by cell membrane invaginations sharing the features of clathrin-coated pits and then internalized into coated cytoplasmic vesicles. Further investigation indicated that WSSV internalization was significantly inhibited by chlorpromazine (CPZ) but not genistein...
December 2015: Virology
https://www.readbyqxmd.com/read/26380977/a-novel-detection-platform-for-shrimp-white-spot-syndrome-virus-using-an-icp11-dependent-immunomagnetic-reduction-imr-assay
#13
Bing-Hsien Liu, Yu-Chen Lin, Chia-Shin Ho, Che-Chuan Yang, Yun-Tsui Chang, Jui-Feng Chang, Chun-Yuan Li, Cheng-Shun Cheng, Jiun-Yan Huang, Yen-Fu Lee, Ming-Hung Hsu, Feng-Chun Lin, Hao-Ching Wang, Chu-Fang Lo, Shieh-Yueh Yang, Han-Ching Wang
Shrimp white spot disease (WSD), which is caused by white spot syndrome virus (WSSV), is one of the world's most serious shrimp diseases. Our objective in this study was to use an immunomagnetic reduction (IMR) assay to develop a highly sensitive, automatic WSSV detection platform targeted against ICP11 (the most highly expressed WSSV protein). After characterizing the magnetic reagents (Fe3O4 magnetic nanoparticles coated with anti ICP11), the detection limit for ICP11 protein using IMR was approximately 2 x 10(-3) ng/ml, and the linear dynamic range of the assay was 0...
2015: PloS One
https://www.readbyqxmd.com/read/26379376/children-and-parent-s-attitude-and-preferences-of-dentist-s-attire-in-pediatric-dental-practice
#14
REVIEW
Vijaya Prasad Kamavaram Ellore, Mudasser Mohammed, Mahanthesh Taranath, Naveen Kumar Ramagoni, Vinod Kumar, Gururaj Gunjalli
BACKGROUND: Before arrival into doctor's clinic, child might have acquired an impression of a clinical environment and doctor's appearance. Different kind of doctor's attire may evoke different reactions. By understanding children and parent's perception and preferences about dentist's attire, a suitable dress code could be adopted to establish good rapport with children. AIM: To evaluate children and parental perceptions and preferences towards dentist attire. MATERIALS AND METHODS: A questionnaire designed with series of photographs of male and female dental students in different attires was responded by 150 parents aged 29 to 63 years and 150 children aged 9 to 13 years...
May 2015: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/26262025/towards-improving-hypertensive-patients-care-pervasive-monitoring-and-diagnosis-support
#15
Jorge Céspedes, Cynthia Villalba
Hypertension is the most common chronic condition dealt with by primary care physicians and other health practitioners. It usually has no symptoms, causing a delay in diagnosis. Moreover, around 20% of the global population suffers from "white-coat syndrome", which can lead to misdiagnosing hypertension. When diagnosed, patients find it difficult to constantly monitor their blood pressure to ensure it is within acceptable levels. In this work, we propose a pervasive solution model for ambulatory monitoring of hypertensive patients and for supporting a clinician with the task of diagnosing hypertension...
2015: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/25801624/the-clinical-utility-of-ambulatory-blood-pressure-monitoring-abpm-a-review
#16
REVIEW
Harry Harianto, Michael Valente, Soenarno Hoetomo, Mahesan Anpalahan
The current evidence suggests that ambulatory blood pressure monitoring (ABPM) should be an integral part of the diagnosis and management of hypertension. However, its uptake in routine clinical practice has been variable. This paper reviews the current evidence for the role of ABPM in clinical practice, including in hypotensive disorders and in specific comorbidities. It further discusses the clinical significance of abnormal ambulatory blood pressure patterns and hypertensive syndromes such as white coat, masked and resistant hypertension...
2014: Current Hypertension Reviews
https://www.readbyqxmd.com/read/25767288/clinical-value-of-ambulatory-blood-pressure-evidence-and-limits
#17
REVIEW
Giuseppe Mancia, Paolo Verdecchia
This article reviews the clinical value of ambulatory blood pressure (BP) vis-à-vis the traditional BP measurements taken in the physician's office or in the hospital. Mention is initially made that longitudinal studies conducted in the general population or in hypertensive cohorts have shown that ambulatory BP provides a more accurate prediction of outcome than office BP. Namely, that (1) the risk of cardiovascular events increases in a less steep fashion with office than with 24-hour mean BP, (2) the 24-hour BP-dependent prediction is maintained after adjustment for office BP values, and (3) among individuals with normal office BP, those with increased ambulatory BP (masked hypertension) have an increased prevalence of organ damage, a more frequent unfavorable metabolic profile and a higher risk of new onset sustained hypertension, diabetes mellitus, and cardiovascular events than those with normal ambulatory BP...
March 13, 2015: Circulation Research
https://www.readbyqxmd.com/read/25651842/early-art-after-cryptococcal-meningitis-is-associated-with-cerebrospinal-fluid-pleocytosis-and-macrophage-activation-in-a-multisite-randomized-trial
#18
RANDOMIZED CONTROLLED TRIAL
James E Scriven, Joshua Rhein, Katherine Huppler Hullsiek, Maximilian von Hohenberg, Grace Linder, Melissa A Rolfes, Darlisha A Williams, Kabanda Taseera, David B Meya, Graeme Meintjes, David R Boulware
INTRODUCTION: Earlier antiretroviral therapy (ART) initiation in cryptococcal meningitis resulted in higher mortality compared with deferred ART initiation (1-2 weeks vs 5 weeks postmeningitis diagnosis). We hypothesized this was due to ART-associated immune pathology, without clinically recognized immune reconstitution inflammatory syndrome. METHODS: Three macrophage activation markers and 19 cytokines/chemokines were measured from cryopreserved cerebrospinal fluid (CSF) and serum during the Cryptococcal Optimal ART Timing (COAT) trial...
September 1, 2015: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/25518029/an-overlooked-cause-of-resistant-hypertension-upper-airway-resistance-syndrome-preliminary-results
#19
Muntecep Asker, Selvi Asker, Ugur Kucuk, Hilal Olgun Kucuk
OBJECTIVE: Upper airway resistance syndrome is a sleep-disordered breathing syndrome that is characterized by repetitive arousals resulting in sympathetic overactivity. We aimed to determine whether upper airway resistance syndrome was associated with poorly controlled hypertension. METHODS: A total of 40 patients with resistant hypertension were enrolled in the study. All of the patients underwent polysomnographic examinations and 24-hour ambulatory blood pressure monitoring to exclude white coat syndrome and to monitor treatment efficiency...
November 2014: Clinics
https://www.readbyqxmd.com/read/25332913/closer-look-at-white-coat-hypertension
#20
REVIEW
Nurver Turfaner Sipahioglu, Fikret Sipahioglu
This review aims to clarify novel concepts regarding the clinical and laboratory aspects of white-coat hypertension (WCHT). Recent studies on the clinical and biological implications of WCHT were compared with existing knowledge. Studies were included if the WCHT patients were defined according to the 2013 European Society of Hypertension guidelines, i.e., an office blood pressure (BP) of ≥ 140/90 mmHg, a home BP of ≤ 135/85 mmHg, and a mean 24-h ambulatory BP of ≤ 130/80 mmHg. WCHT studies published since 2000 were selected, although a few studies performed before 2000 were used for comparative purposes...
September 26, 2014: World Journal of Methodology
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