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Vitamin D in pregnancy

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https://www.readbyqxmd.com/read/28093352/cyp24a1-loss-of-function-clinical-phenotype-of-monoallelic-and-biallelic-mutations
#1
REVIEW
Thomas O Carpenter
CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH)2D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1,25-(OH)2D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite and storage form of the vitamin. CYP24A1 can be stimulated hormonally by 1,25-(OH)2D and by FGF23, whereas CYP27B1, encoding the vitamin D-1α-hydroxylase, is stimulated hormonally by parathyroid hormone (PTH) and downregulated by FGF23...
January 13, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28079560/prenatal-exposures-and-the-development-of-childhood-wheezing-illnesses
#2
Christian Rosas-Salazar, Tina V Hartert
PURPOSE OF REVIEW: To critically evaluate and summarize studies published between July 2015 and June 2016 linking prenatal exposures and the onset of childhood wheezing illnesses and to discuss future research directions in this field. RECENT FINDINGS: The aggregated evidence indicates a consistent detrimental effect of prenatal exposure to parental smoking, outdoor air pollution, and maternal stress on childhood wheezing illnesses. Less consistent evidence suggests an adverse impact of maternal obesity during pregnancy and prenatal exposure to antibiotics on these outcomes...
January 11, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28065633/micronutrient-intake-is-inadequate-for-a-sample-of-pregnant-african-american-women
#3
Susan W Groth, Patricia A Stewart, Deborah J Ossip, Robert C Block, Nellie Wixom, I Diana Fernandez
BACKGROUND: Micronutrient intake is critical for fetal development and positive pregnancy outcomes. Little is known about the adequacy of micronutrient intake in pregnant African-American women. OBJECTIVE: To describe nutrient sufficiency and top food groups contributing to dietary intake of select micronutrients in low-income pregnant African-American women and determine whether micronutrient intake varies with early pregnancy body mass index (BMI) and/or gestational weight gain...
January 5, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28058102/prevalence-demographic-characteristics-and-associated-risk-factors-of-malnutrition-among-0-5-aged-children-a-cross-sectional-study-from-van-eastern-turkey
#4
Baran Serdar Kizilyildiz, Bülent Sönmez, Kamuran Karaman, Burhan Beger, Adnan Mercen, Süleyman Alioglu, Yasar Cesur
Malnutrition in childhood is a dramatic indicator of poor socio-economical status worldwide. To recognize and reveal the socio-demographic features is crucial, especially for developing countries. Our aim was to investigate the prevalence and association with sociodemographic variables of malnutrition in 0-5 years old children in Van, Turkey. A total of 702 children are included in this cross-sectional study. Demographic features of subject including age, gender, family characteristics and other data were obtained...
November 17, 2016: Pediatric Reports
https://www.readbyqxmd.com/read/28043188/maternal-serum-vitamin-d-and-parathormone-concentrations-during-gestation-and-in-umbilical-cord-blood-pilot-study
#5
Anastasiya Zasimovich, Anna Fijałkowska, Magdalena Chełchowska, Tomasz Maciejewski
OBJECTIVE: We wanted to define levels of vitamin D (25(OH)D), parathormone (PTH), calcium (Ca), phosphorus (P) and the correlations between them during gestation as well as in umbilical cord blood. METHODS: The study included 37 healthy singleton pregnant women in the course of gestation with no medical history concerning systemic diseases, nor with negative obstetrics and gynecological history. Biochemical parameters were determined using commercially available kits...
January 2, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28027638/effects-of-bifidobacterium-animalis-lactis-hn019-dr10tm-inulin-and-micronutrient-fortified-milk-on-faecal-dr10tm-immune-markers-and-maternal-micronutrients-among-indonesian-pregnant-women
#6
Noroyono Wibowo, Saptawati Bardosono, Rima Irwinda
BACKGROUND AND OBJECTIVES: Maternal nutrition affects fetal growth and development. This study evaluates the effects of milk powder fortified with micronutrients, docosahexaenoic acid (DHA), a prebiotic, and probiotic Bifidobacterium animalis subsp. lactis HN019 DR10TM on the micronutrient status, as well as the presence of faecal probiotic and immune markers in pregnant women. METHODS AND STUDY DESIGN: This randomised, double- blind, placebo-controlled trial was conducted at Budi Kemuliaan and Cipto Mangunkusumo Hospital in Jakarta from 2013 to 2014...
December 2016: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28026707/determinants-of-vitamin-d-status-in-pregnant-women-and-neonates
#7
Christy G Woolcott, Yves Giguère, Hope A Weiler, Anne Spencer, Jean-Claude Forest, B Anthony Armson, Linda Dodds
OBJECTIVES: Evidence suggests a beneficial effect of vitamin D on perinatal health; however, low vitamin D status is prevalent in pregnant women and neonates. The objective was to determine factors that are associated with vitamin D status of mothers in early pregnancy and neonates. METHODS: The study comprised 1,635 pregnant women from Quebec City and Halifax, Canada, 2002-2010. Vitamin D status was based on the concentration of 25-hydroxy-vitamin D [25(OH)D] determined with a chemiluminescence immunoassay in maternal sera collected at a median of 15 weeks' gestation and in neonatal cord sera at delivery...
December 27, 2016: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28012571/perinatal-nutrition-interventions-and-post-partum-depressive-symptoms
#8
REVIEW
Jacqueline F Gould, Karen Best, Maria Makrides
BACKGROUND: Postpartum depression (PPD) is the most prevalent mood disorder associated with childbirth. No single cause of PPD has been identified, however the increased risk of nutritional deficiencies incurred through the high nutritional requirements of pregnancy may play a role in the pathology of depressive symptoms. Three nutritional interventions have drawn particular interest as possible non-invasive and cost-effective prevention and/or treatment strategies for PPD; omega-3 (n-3) long chain polyunsaturated fatty acids (LCPUFA), vitamin D and overall diet...
December 18, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28007533/vitamin-d-metabolite-concentrations-in-umbilical-cord-blood-serum-and-associations-with-clinical-characteristics-in-a-large-prospective-mother-infant-cohort-in-ireland
#9
Mairead Kiely, Sinead M O'Donovan, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Vitamin D deficiency is widespread among mothers and neonates and quality clinical and analytical data are lacking. We used a CDC-accredited LC-MS/MS method to analyze vitamin D metabolites in cord sera from 1050 maternal-infant dyads in the prospective SCOPE Ireland Pregnancy and BASELINE Birth cohort studies, based in Cork, Ireland. The mean±SD total 25(OH)D was 34.9±18.1nmol/L; 35% of cords (50% during winter) had 25(OH)D <25nmol/L, 46% were <30nmol/L and 80% were <50nmol/L. In this predominantly white cohort, the main predictor of cord 25(OH)D [adj...
December 19, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28004271/maternal-vitamin-d-deficiency-during-pregnancy-affects-expression-of-adipogenic-regulating-genes-peroxisome-proliferator-activated-receptor-gamma-ppar%C3%AE-and-vitamin-d-receptor-vdr-in-lean-male-mice-offspring
#10
Anthony M Belenchia, Karen L Jones, Matthew Will, David Q Beversdorf, Victoria Vieira-Potter, Cheryl S Rosenfeld, Catherine A Peterson
PURPOSE: Maternal vitamin D deficiency during pregnancy is a widespread issue that may have long-lasting consequences on offspring adiposity. We sought to determine how maternal vitamin D deficiency during the perinatal period would affect offspring adipose tissue development and gene expression. METHODS: Female C57BL/6 J mice were fed either a vitamin D deficient (VDD) or control diet from 4 weeks before pregnancy (periconception) until 7 days postparturition...
December 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/28002913/pregnancy-associated-osteoporosis-pao-with-multiple-vertebral-fragility-fractures-diagnosis-and-treatment-in-a-young-primigravid-woman
#11
E Pola, D Colangelo, L A Nasto, V Pambianco, G Autore, V M Formica, G Maccauro
PAO is an uncommon condition affecting pregnant women during last trimester or early post-delivery period; it is often asymptomatic or presents with pain related to some acute fragility fractures. The diagnosis is often delayed or missed, the etiology remains unknown and no guidelines about treatment have been published. We present one case of PAO in a 33-year-old primigravid woman presenting acute worsening back pain. Our patient was treated with a TLSO brace, oral 25 (OH)-vitamin D supplementation and Teriparatide for 6 months...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27992038/-high-prevalence-of-inadequate-calcium-and-vitamin-d-dietary-intake-in-two-cohorts-of-pregnant-women
#12
Caroline de Barros Gomes, Maíra Barreto Malta, José Eduardo Corrente, Maria Helena D'Aquino Benício, Maria Antonieta de Barros Leite Carvalhaes
This study aimed to identify the prevalence of inadequate calcium and vitamin D dietary intake and related factors in two cohorts of pregnant women according to trimester of pregnancy. Two 24-hour dietary recall tests were taken in each trimester, one pertaining to weekends. Variables significantly correlated with intake of these nutrients were included in a multivariate linear regression model, adjusted for energy. Prevalence of inadequate intake was estimated according to the National Cancer Institute method (United States)...
December 15, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27981740/maternal-vitamin-d-status-during-pregnancy-and-risk-of-childhood-asthma%C3%A0-a-meta-analysis-of-prospective-studies
#13
Huihui Song, Lei Yang, Chongqi Jia
SCOPE: Mounting evidence suggests that maternal vitamin D status during pregnancy may be associated with development of childhood asthma, but the results are still inconsistent. A dose-response meta-analysis was performed to quantitatively summarize evidence on the association of maternal vitamin D status during pregnancy with the risk of childhood asthma. METHODS AND RESULTS: A systematic search was conducted to identify all studies assessing the association of maternal 25-hydroxyvitamin D (25(OH)D) during pregnancy with risk of childhood asthma...
December 16, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27977549/infant-respiratory-tract-infections-or-wheeze-and-maternal-vitamin-d-in-pregnancy-a-systematic-review
#14
Nikolas Christensen, Jens Sondergaard, Niels Fisker, Henrik Thybo Christesen
: Respiratory tract infections (RTIs) are a common cause of morbidity and mortality in young children and can be associated with wheeze. Vitamin D can have a protective role against RTI. MATERIALS AND METHODS: A systematic search of Pubmed, Embase and the Cochrane library was performed. Titles and abstracts were evaluated and selected articles were reviewed by two authors. We included randomized controlled trials (RCTs) investigating the effect of vitamin D supplementation during pregnancy on RTIs or wheeze in children of 5 years of age or younger...
December 12, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27968954/childhood-leukemia-and-primary-prevention
#15
Todd P Whitehead, Catherine Metayer, Joseph L Wiemels, Amanda W Singer, Mark D Miller
Leukemia is the most common pediatric cancer, affecting 3800 children per year in the United States. Its annual incidence has increased over the last decades, especially among Latinos. Although most children diagnosed with leukemia are now cured, many suffer long-term complications, and primary prevention efforts are urgently needed. The early onset of leukemia-usually before 5 years of age-and the presence at birth of "pre-leukemic" genetic signatures indicate that pre- and postnatal events are critical to the development of the disease...
October 2016: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/27966300/relationship-between-gestational-transient-thyrotoxicosis-and-vitamin-d
#16
Ferit Kerim Küçükler, Yasin Şimşek, Ümit Görkem, Berçem Ayçiçek Doğan, Serdar Güler
BACKGROUND/AIM: Gestational transient thyrotoxicosis (GTT) is a transient, mild hyperthyroidism that occurs early in pregnancy and is due to human chorionic gonadotropin. There is no clear information about why only some pregnant women develop GTT. Previous papers stated that vitamin D plays a role in thyroid functions. We aimed to evaluate the relationship between vitamin D and GTT. MATERIALS AND METHODS: Fifty-three patients diagnosed with GTT at the 6th to 10th weeks of gestation were included in the study (GTT group)...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27958635/influence-of-apa1-rs7975232-taq1-rs731236-and-bsm1-rs154410-polymorphisms-of-vitamin-d-receptor-on-preterm-birth-risk-in-the-polish-population
#17
Marta Baczyńska-Strzecha, Jarosław Kalinka
OBJECTIVES: Vitamin D receptor (VDR) is expressed in the placenta and tissues related to the immune system occurrence of various variants of VDR may modify the effects of vitamin D on pregnancy. The aim of this study was to evaluate the association between the parturients' Apa1, Taq1, and Bsm1 polymorphisms of the VDR and their combinations and the risk of preterm birth in the Polish population. MATERIAL AND METHODS: Determination of polymorphism for VDR was assayed using the RT-PCR method...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27956114/1-25-dihydroxy-vitamin-d3-stimulates-system-a-amino-acid-transport-in-primary-human-trophoblast-cells
#18
Yi-Yung Chen, Theresa L Powell, Thomas Jansson
Vitamin D deficiency during pregnancy is linked to adverse perinatal outcomes such as small for gestational age infants. Recent evidence suggests that changes in placental amino acid transport contribute to altered fetal growth. We tested the hypothesis that 1,25-dihydroxy vitamin D3 increases the gene expression of System A and L amino acid transporter isoforms and stimulates placental amino acid transport activity in cultured primary human trophoblast cells mediated by mTOR signaling. Treatment with 1,25-dihydroxy vitamin D3 significantly increased mRNA expression of the System A isoform SNAT2 and System A activity, but had no effect on System L and did not affect mTOR signaling...
December 9, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27941597/maternal-vitamin-d-status-and-adverse-birth-outcomes-in-children-from-rural-western-kenya
#19
Eunice N Toko, Odada P Sumba, Ibrahim I Daud, Sidney Ogolla, Maxwel Majiwa, Jesse T Krisher, Collins Ouma, Arlene E Dent, Rosemary Rochford, Saurabh Mehta
Maternal plasma 25-hydroxyvitamin D (25(OH)D) status and its association with pregnancy outcomes in malaria holoendemic regions of sub-Saharan Africa is poorly defined. We examined this association and any potential interaction with malaria and helminth infections in an ongoing pregnancy cohort study in Kenya. The association of maternal plasma 25(OH)D status with pregnancy outcomes and infant anthropometric measurements at birth was determined in a subset of women (n = 63). Binomial and linear regression analyses were used to examine associations between maternal plasma 25(OH)D and adverse pregnancy outcomes...
December 7, 2016: Nutrients
https://www.readbyqxmd.com/read/27939956/maternal-vitamin-d-biomarkers-are-associated-with-maternal-and-fetal-bone-turnover-among-pregnant-women-consuming-controlled-amounts-of-vitamin-d-calcium-and-phosphorus
#20
Heyjun Park, Patsy M Brannon, Allyson A West, Jian Yan, Xinyin Jiang, Cydne A Perry, Olga Malysheva, Saurabh Mehta, Marie A Caudill
Vitamin D plays a central role in calcium homeostasis; however, its relationship with bone turnover during pregnancy remains unclear due to a lack of studies that have rigorously controlled for vitamin D and other nutrients known to influence bone metabolism. Similarly, prior investigations of the effect of pregnancy on bone turnover relative to the nonpregnant state may have been confounded by varying intakes of these nutrients. Nested within a controlled intake study, the present investigation sought to quantify associations between maternal vitamin D biomarkers and biochemical markers of bone turnover among pregnant (versus nonpregnant) women and their fetuses under conditions of equivalent and adequate intakes of vitamin D and related nutrients...
February 2017: Bone
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