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Vitamin D in pregnancy

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https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#1
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903519/dairy-intake-and-fecundability-in-2-preconception-cohort-studies
#2
Lauren A Wise, Amelia K Wesselink, Ellen M Mikkelsen, Heidi Cueto, Kristen A Hahn, Kenneth J Rothman, Katherine L Tucker, Henrik Toft Sørensen, Elizabeth E Hatch
BACKGROUND: Animal studies have shown that a high intake of galactose, a breakdown product of lactose, increases ovarian toxicity. Few epidemiologic studies, to our knowledge, have examined the association between dairy intake and fertility, and they have had conflicting findings. OBJECTIVE: We prospectively evaluated dairy intake in relation to fecundability among women who were planning for pregnancy. DESIGN: Data were derived from preconception cohort studies in Denmark (Snart Foraeldre) and North America [PRESTO (Pregnancy Study Online)] in which women completed a validated food-frequency questionnaire 10 d after enrollment...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27903510/vitamin-d-supplementation-reduces-some-at1-aa-induced-downstream-targets-implicated-in-preeclampsia-including-hypertension
#3
Jessica L Faulkner, Lorena M Amaral, Denise C Cornelius, Mark W Cunningham, Tarek Ibrahim, Autumn Heep, Nathan Campbell, Nathan Usry, Kedra Wallace, Florian Herse, Ralf Dechend, Babbette D LaMarca
Autoantibodies to the angiotensin II (ANGII) type I receptor (AT1-AA) are associated with preeclampsia (PE). We found that Vitamin D supplementation reduced AT1-AA and blood pressure (MAP) in the RUPP rat model of PE. However, it was undetermined if the decrease in AT1-AA was the mechanism whereby Vitamin D lowered MAP or if it was through factors downstream of AT1-AA. Uterine artery resistance index, placental ET-1 and sFlt-1 are increased with AT1-AA induced hypertension and considered markers of PE in pregnant women...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27898926/assessment-of-serum-25-hydroxyvitamin-d-concentrations-of-beef-cows-and-calves-across-seasons-and-geographical-locations
#4
C D Nelson, J L Powell, D M Price, M J Hersom, J V Yelich, M E Drewnoski, S L Bird, G Allen Bridges
Vitamin D is critical for the growth and development of calves and positively contributes to immune function of cattle. Serum 25-hydroxyvitamin D (25(OH)D) concentrations above 20 ng/mL have traditionally been considered adequate for growth and development of cattle, but recent evidence has indicated that concentrations below 30 ng/mL are insufficient for immunity. Because little information is available regarding vitamin D status of beef cattle, the objective of this study was to evaluate vitamin D status of beef cow-calf herds on pasture as affected by season and location...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27888033/prenatal-intake-of-vitamins-and-allergic-outcomes-in-the-offspring-a-systematic-review-and-meta-analysis
#5
Mariam Vahdaninia, Heather Mackenzie, Suzannah Helps, Taraneh Dean
BACKGROUND: Allergic diseases have seen a rise worldwide, with children suffering the highest burden. Thus, early prevention of allergic diseases is a public health priority. OBJECTIVE: To synthesize the evidence from randomized controlled trials (RCTs) assessing the effect of vitamin interventions during pregnancy on developing allergic diseases in offspring. METHODS: We searched CENTRAL, MEDLINE, SCOPUS, World Health Organization's International Clinical Trials Registration, E-theses, and Web of Science...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27865346/maternal-fat-soluble-vitamins-brain-development-and-regulation-of-feeding-behavior-an-overview-of-research
#6
REVIEW
Diana Sánchez-Hernández, G Harvey Anderson, Abraham N Poon, Emanuela Pannia, Clara E Cho, Pedro S P Huot, Ruslan Kubant
Recent research shows a link between vitamin intake during pregnancy and offspring health. Inadequate intakes of water-soluble vitamins during pregnancy lead to obesity and characteristics of the metabolic syndrome, concurrent with altered developments in food intake regulatory pathways. Few studies, however, have reported on the effects of fat-soluble vitamins (A, D, E, and K) on the development of food intake regulatory pathways. The majority of studies to date have focused on associations between inadequate and high intakes of folic acid and vitamin D and neurocognitive development of the offspring...
October 2016: Nutrition Research
https://www.readbyqxmd.com/read/27862673/vitamin-d-restores-angiogenic-balance-and-decreases-tumor-necrosis-factor-%C3%AE-in-a-rat-model-of-pre-eclampsia
#7
Jing Song, Yue Li, Ruifang An
AIM: Deficiency of vitamin D is correlated with pre-eclampsia (PE), a hypertensive disorder of pregnancy, and is characterized by angiogenic imbalance and inflammation. The aim of this study was to investigate whether vitamin D supplementation can restore the angiogenic balance and ameliorate inflammation in a rat model of PE. METHODS: PE was induced using l-nitroarginine methylester. Normal pregnant and PE-induced rats were supplemented with vitamin D on gestation days 14-19...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27862146/maternal-25-hydroxyvitamin-d-is-inversely-correlated-with-fetal-serotonin
#8
Padma Murthi, Miranda Davies-Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M Wallace, Peter R Ebeling
OBJECTIVE: Maternal vitamin D deficiency during pregnancy has been linked to impaired neurocognitive development in childhood. The mechanism by which vitamin D affects childhood neurocognition is unclear but may be via interactions with serotonin, a neurotransmitter involved in fetal brain development. In this study we aimed to explore associations between maternal and fetal vitamin D concentrations, and fetal serotonin concentrations at term. STUDY DESIGN AND MEASUREMENTS: Serum 25-hydroxyitamin D (25(OH)D, nmol/L) and serotonin (5-HT, nmol/L) concentrations were measured in maternal and umbilical cord blood from mother-infant pairs (n=64)...
November 12, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27851719/the-correlation-between-serum-vitamin-d-deficiency-and-preterm-birth
#9
Lixia Yang, Shilei Pan, Yufeng Zhou, Xiaoyang Wang, Aikai Qin, Yuxin Huang, Suxia Sun
BACKGROUND Preterm birth is an important cause of death and developmental disorder in neonates. Vitamin D deficiency has been shown to regulate body inflammatory factor levels that stimulate elevation of uterine contraction hormones, such as prostaglandin, thus causing preterm birth. However, current observations regarding the relationship between vitamin D and preterm birth are inconsistent. We performed a nested case-control study to investigate the effect of vitamin D on preterm birth. MATERIAL AND METHODS A prospective cohort study included 200 cases of pregnant women in our hospital from May 2013 to May 2015...
November 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27843556/seasonality-of-gestational-diabetes-mellitus-a-south-australian-population-study
#10
Petra E Verburg, Graeme Tucker, Wendy Scheil, Jan Jaap H M Erwich, Gus A Dekker, Claire T Roberts
OBJECTIVE: To investigate whether there is a seasonal variation in the incidence of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: This retrospective cohort study of 60 306 eligible South Australian live-born singletons during 2007-2011 recorded in the South Australian Perinatal Statistics Collection (SAPSC) examined the incidence of GDM in relation to estimated date of conception (eDoC). Fourier series analysis was used to model seasonal trends...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27826434/development-and-piloting-of-a-food-based-intervention-to-increase-vitamin-e-intake-in-pregnant-women-in-a-randomized-controlled-trial
#11
Julia Clark, Nikki Holgan, Leone Craig, Heather Morgan, Peter Danielian, Graham Devereux
Low maternal vitamin E intake during pregnancy is associated with childhood asthma and a trial is required to test whether increasing maternal vitamin E intake reduces childhood asthma. This study investigated whether such a trial is possible using food to increase vitamin E intake. Three soup varieties with enhanced vitamin E content (16-19 mg/can) from food ingredients were developed. Near identical retail versions (vitamin E 1-4 mg/can) acted as placebo. In a pilot double-blind randomized controlled trial, pregnant women were randomized 1:1 to enhanced or placebo soups (three tins/week) from 12 weeks gestation to delivery...
November 2016: Food Science & Nutrition
https://www.readbyqxmd.com/read/27818017/low-maternal-25-hydroxyvitamin-d-concentration-increases-the-risk-of-severe-and-mild-preeclampsia
#12
Katharyn M Baca, Hyagriv N Simhan, Robert W Platt, Lisa M Bodnar
PURPOSE: The objective of this case-cohort study was to evaluate the relationship between maternal 25-hydroxyvitamin D (25(OH)D) concentration and preeclampsia overall and by severity. METHODS: From an eligible cohort of 12,861 women who had serum banked from aneuploidy screening in Pittsburgh, Pennsylvania from 1999 to 2010, we randomly sampled a subcohort of 2327 pregnancies and all remaining preeclampsia cases (n = 650 cases). Preeclampsia (defined as new-onset hypertension and proteinuria) and its mild and severe forms were identified using ICD-9 codes...
December 2016: Annals of Epidemiology
https://www.readbyqxmd.com/read/27814705/maternal-urinary-metabolic-signatures-of-fetal-growth-and-associated-clinical-and-environmental-factors-in-the-inma-study
#13
Léa Maitre, Cristina M Villanueva, Matthew R Lewis, Jesús Ibarluzea, Loreto Santa-Marina, Martine Vrijheid, Jordi Sunyer, Muireann Coen, Mireille B Toledano
BACKGROUND: Maternal metabolism during pregnancy is a major determinant of the intra-uterine environment and fetal outcomes. Herein, we characterize the maternal urinary metabolome throughout pregnancy to identify maternal metabolic signatures of fetal growth in two subcohorts and explain potential sources of variation in metabolic profiles based on lifestyle and clinical data. METHODS: We used (1)H nuclear magnetic resonance (NMR) spectroscopy to characterize maternal urine samples collected in the INMA birth cohort at the first (n = 412 and n = 394, respectively, in Gipuzkoa and Sabadell cohorts) and third trimesters of gestation (n = 417 and 469)...
November 4, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27807601/maternal-dietary-nutrient-intake-during-pregnancy-and-offspring-linear-growth-and-bone-the-vitamin-d-in-pregnancy-cohort-study
#14
Natalie K Hyde, Sharon L Brennan-Olsen, John D Wark, Sarah M Hosking, Julie A Pasco
Magnesium, phosphorus, zinc, calcium, potassium and protein all play integral roles in maintaining bone health in adults; however, less is known about the importance of these minerals in utero. We aimed to determine associations between maternal dietary consumption of these nutrients during gestation and birth measures in offspring. Of 475 pregnant women recruited from a single antenatal clinic before 16-week gestation (2002-2003) as part of the vitamin D in pregnancy study, 346 with recorded maternal dietary intakes at 28- to 32-week gestation and offspring measures at birth were included...
November 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27806685/prepartum-body-condition-score-and-plane-of-nutrition-affect-the-hepatic-transcriptome-during-the-transition-period-in-grazing-dairy-cows
#15
M Vailati-Riboni, S Meier, C R Burke, J K Kay, M D Mitchell, C G Walker, M A Crookenden, A Heiser, S L Rodriguez-Zas, J R Roche, J J Loor
BACKGROUND: A transcriptomic approach was used to evaluate potential interactions between prepartum body condition score (BCS) and feeding management in the weeks before calving on hepatic metabolism during the periparturient period. METHODS: Thirty-two mid-lactation grazing dairy cows of mixed age and breed were randomly allocated to one of four treatment groups in a 2 × 2 factorial arrangement: two prepartum BCS categories [4.0 (thin, BCS4) and 5.0 (optimal, BCS5); based on a 10-point scale], and two levels of energy intake during the 3 weeks preceding calving (75 and 125 % of estimated requirements)...
November 2, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27806501/effect-of-vitamin-d-supplementation-on-unexplained-recurrent-spontaneous-abortion-a-double-blind-randomized-controlled-trial
#16
Mansoureh Samimi, Fatemeh Foroozanfard, Farzaneh Amini, Mojtaba Sehat
BACKGROUND: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA). METHODS: A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively...
July 12, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27798048/the-prevalence-of-unplanned-pregnancy-ending-in-birth-associated-factors-and-health-outcomes
#17
J Goossens, Y Van Den Branden, L Van der Sluys, I Delbaere, A Van Hecke, S Verhaeghe, D Beeckman
STUDY QUESTION: What are associated factors of unplanned pregnancies ending in birth? SUMMARY ANSWER: Pregnancies that were less planned were associated with women of lower socio-economic status (SES), an unhealthier lifestyle before and during the pregnancy, more stress, and less social support. WHAT IS KNOWN ALREADY: In Europe, the prevalence of unplanned pregnancy leading to birth varies. Unplanned pregnancy is more common among socially disadvantaged women, and associated with adverse pregnancy outcomes...
October 24, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27793368/loss-of-placental-thrombomodulin-in-oocyte-donation-pregnancies
#18
Manon Bos, Hans J Baelde, Jan A Bruijn, Kitty W M Bloemenkamp, Marie-Louise P van der Hoorn, Rosanne J Turner
OBJECTIVE: To investigate whether thrombomodulin dysregulation is involved in the development of preeclampsia after oocyte donation (OD). Women who become pregnant after OD are prone to develop preeclampsia, a syndrome characterized by an aberrant immunologic response, hypercoagulability, and endothelial dysfunction. A mediator of inflammation and coagulation is thrombomodulin, which has a possible role to play in this syndrome. DESIGN: Case-control study. SETTING: Not applicable...
October 25, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27792161/maternal-dietary-vitamin-d-does-not-program-systemic-inflammation-and-bone-health-in-adult-female-mice-fed-an-obesogenic-diet
#19
Christopher R Villa, Jianmin Chen, Bijun Wen, Sandra M Sacco, Amel Taibi, Wendy E Ward, Elena M Comelli
Obesity is associated with systemic inflammation and impaired bone health. Vitamin D regulates bone metabolism, and has anti-inflammatory properties and epigenetic effects. We showed that exposure to high dietary vitamin D during pregnancy and lactation beneficially programs serum concentration of lipopolysaccharide (LPS) and bone structure in male offspring fed an obesogenic diet. Here we assessed if this effect is also apparent in females. C57BL/6J dams were fed AIN93G diet with high (5000 IU/kg diet) or low (25 IU/kg diet) vitamin D during pregnancy and lactation...
October 26, 2016: Nutrients
https://www.readbyqxmd.com/read/27788053/determinants-of-the-maternal-25-hydroxyvitamin-d-response-to-vitamin-d-supplementation-during-pregnancy
#20
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper, Stefania D'Angelo, Sarah R Crozier, Hazel M Inskip, Inez Schoenmakers, Ann Prentice, Nigel K Arden, Nicholas J Bishop, Andrew Carr, Elaine M Dennison, Richard Eastell, Robert Fraser, Saurabh V Gandhi, Keith M Godfrey, Stephen Kennedy, M Zulf Mughal, Aris T Papageorghiou, David M Reid, Sian M Robinson, M Kassim Javaid
CONTEXT: Current approaches to antenatal vitamin D supplementation do not account for interindividual differences in 25-hydroxyvitamin D (25(OH)D) response. OBJECTIVE: We assessed which maternal and environmental characteristics were associated with 25(OH)D after supplementation with cholecalciferol. DESIGN: Within-randomization-group analysis of participants in the Maternal Vitamin D Osteoporosis Study trial of vitamin D supplementation in pregnancy...
October 27, 2016: Journal of Clinical Endocrinology and Metabolism
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