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Vitamin D in pregnancy

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https://www.readbyqxmd.com/read/29039975/maternal-and-cord-blood-cyclophilin-a-in-severe-preeclampsia-and-normal-pregnancy-and-its-correlation-with-vitamin-d-and-zinc
#1
Noroyono Wibowo, Riyan Hari Kurniawan, Rima Irwinda, Natasya Prameswari
OBJECTIVE: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level. METHODS: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014. RESULTS: Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299...
October 17, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/29028072/vitamin-d-in-human-reproduction-the-more-the-better-an-evidence-based-critical-appraisal
#2
A S Laganà, S G Vitale, H Ban Frangež, E Vrtačnik-Bokal, R D'Anna
OBJECTIVE: Vitamin D is a fat-soluble secosteroid hormone that regulates calcium, magnesium, and phosphate homeostasis and plays a pivotal role as antiproliferative and immunomodulatory mediator. Considering the different sources of synthesis and dietary intake as well as the pleiotropic actions in extremely diverse (micro)environments of the body, the supplementation of this Vitamin should be carefully evaluated taking into account the several pathways that it regulates. In the current brief review, we aimed to summarize the available evidence about the topic, in order to suggest the best evidence-based supplementation strategy for human reproduction, avoiding the unuseful (and sometimes hazardous) empiric supplementation...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29021285/placental-vitamin-d-metabolism-and-its-associations-with-circulating-vitamin-d-metabolites-in-pregnant-women
#3
Heyjun Park, Madeleine R Wood, Olga V Malysheva, Sara Jones, Saurabh Mehta, Patsy M Brannon, Marie A Caudill
Background: Little is known about placental vitamin D metabolism and its impact on maternal circulating vitamin D concentrations in humans.Objective: This study sought to advance the current understanding of placental vitamin D metabolism and its role in modulating maternal circulating vitamin D metabolites during pregnancy.Design: Nested within a feeding study, 24 healthy pregnant women (26-29 wk of gestation) consumed a single amount of vitamin D (511 IU/d from diet and a cholecalciferol supplement) for 10 wk...
October 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28989883/status-of-serum-vitamin-d-and-calcium-levels-in-women-of-reproductive-age-in-national-capital-territory-of-india
#4
Nighat Yaseen Sofi, Monika Jain, Umesh Kapil, Vuthaluru Seenu, Lakshmy Ramakrishnan, Chander Prakash Yadav, Ravindra Mohan Pandey
CONTEXT: In India, Vitamin D deficiency is a major public health problem, associated with lack of sunlight exposure in spite of abundant sunshine usually accompanied by reduced dietary intake. In women of reproductive age, Vitamin D deficiency in pregnancy has been associated with an increased risk of gestational diabetes mellitus, preeclampsia, maternal and perinatal morbidity and mortality. AIMS: The aim of the present cross-sectional study was to evaluate the levels of serum Vitamin D 25(OH) D and calcium in women of reproductive age from India...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28981319/vitamin-d-supplementation-prevents-placental-ischemia-induced-endothelial-dysfunction-by-downregulating-placental-soluble-fms-like-tyrosine-kinase-1
#5
Su-Ling Ma, Xiao-Yu Tian, Ya-Qi Wang, Hui-Feng Zhang, Lei Zhang
Maternal vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. Vascular endothelial dysfunction is a major phenotype of pregnancies with preeclampsia, contributing to increased maternal hypertension and proteinuria. We sought to determine whether vitamin D supplementation would alleviate preeclampsia associated endothelial dysfunction and explore the underlying mechanism using the reduced uterine perfusion pressure (RUPP) rat model. RUPP operated rats were supplemented with 1,25(OH)2D (RUPP+VD) on day 1, 7, and 14 of pregnancy by subcutaneous injection...
October 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28976992/genetic-determinants-of-serum-25-hydroxyvitamin-d-concentration-during-pregnancy-and-type-1-diabetes-in-the-child
#6
Maija E Miettinen, Melissa C Smart, Leena Kinnunen, Valma Harjutsalo, Linnea Reinert-Hartwall, Irene Ylivinkka, Heljä-Marja Surcel, Christel Lamberg-Allardt, Graham A Hitman, Jaakko Tuomilehto
OBJECTIVE: The in utero environment plays an important role in shaping development and later life health of the fetus. It has been shown that maternal genetic factors in the metabolic pathway of vitamin D associate with type 1 diabetes in the child. In this study we analyzed the genetic determinants of serum 25-hydroxyvitamin D (25OHD) concentration during pregnancy in mothers whose children later developed type 1 diabetes and in control mothers. STUDY DESIGN: 474 mothers of type 1 diabetic children and 348 mothers of non-diabetic children were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28976079/pre-pregnancy-habitual-intake-of-vitamin-d-from-diet-and-supplements-in-relation-to-risk-of-gestational-diabetes-mellitus-a-prospective-cohort-study
#7
Wei Bao, Yiqing Song, Kimberly A Bertrand, Deirdre K Tobias, Sjurdur F Olsen, Jorge E Chavarro, James L Mills, Frank B Hu, Cuilin Zhang
BACKGROUND: Vitamin D may play a pivotal role in regulating insulin secretion and insulin sensitivity. However, the impact of vitamin D intake either from diet or from supplements on the development of gestational diabetes mellitus (GDM) remains unknown. We prospectively examined the association of pre-pregnancy habitual intake of vitamin D from diet and supplements with risk of incident GDM in a well-established cohort. METHODS: We included 21,356 singleton pregnancies from 15,225 women in the Nurses' Health Study II cohort...
October 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28965301/minimal-trauma-ankle-fractures-predominate-during-pregnancy-a-17-year-retrospective-study
#8
Madhuni Herath, Phillip Wong, Anne Trinh, Carolyn A Allan, Euan M Wallace, Peter R Ebeling, Peter J Fuller, Frances Milat
This study assessed all fractures occurring in pregnancy at a tertiary referral centre over a 17-year period. Most fractures were due to minimal trauma, and those involving the ankle were the most common. Women tended to fracture during their second and third trimesters and most required surgical intervention during pregnancy. PURPOSE: To characterise fractures in pregnancy over a 17-year period at a tertiary referral health service. METHODS: Medical records at the Monash Health in Australia were examined from 2000-2016 for fractures in pregnancy using the birthing outcome system database and the tenth revision of the International Statistical Classification of Diseases and Related Health Problems coding...
September 30, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28955749/structure-organization-and-tissue-expression-of-the-pig-slc13a1-and-slc13a4-sulfate-transporter-genes
#9
Samuel K Barnes, Yvonne A Eiby, Soohyun Lee, Barbara E Lingwood, Paul A Dawson
Sulfate is an obligate nutrient for fetal growth and development. In mice, the renal Slc13a1 sulfate transporter maintains high maternal circulating levels of sulfate in pregnancy, and the placental Slc13a4 sulfate transporter mediates sulfate supply to the fetus. Both of these genes have been linked to severe embryonal defects and fetal loss in mice. However, the clinical significance of SLC13A1 and SLC13A4 in human gestation is unknown. One approach towards understanding the potential involvement of these genes in human fetal pathologies is to use an animal model, such as the pig, which mimics the developmental trajectory of the human fetus more closely than the previously studied mouse models...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28955691/gestational-diabetes-mellitus-fetal-growth-and-vitamin-d
#10
REVIEW
Hyun Koo Yoon
Vitamin D is an important secosteroid hormone in skeletal and non-skeletal systems. Vitamin D has relevance to muscle and immune function, hypertension, diabetes mellitus, cancer, and pregnancy because vitamin D receptors (VDR) are present in many non-skeletal tissues. Vitamin D acts on target tissues via the binding of its active form to VDR. As vitamin D affects not only bone metabolism but also glucose metabolism, vitamin D deficiency may affect the development of gestational diabetes mellitus and fetal growth...
August 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28954405/vitamin-d-concentration-in-maternal-and-umbilical-cord-blood-by-season
#11
Regina Wierzejska, Mirosław Jarosz, Włodzimierz Sawicki, Michał Bachanek, Magdalena Siuba-Strzelińska
Summer is generally considered to be the season when the body is well-supplied with vitamin D. The aim of this study was to compare maternal and umbilical cord blood concentrations of vitamin D during two extreme seasons of the year in Poland-winter and summer. A total of 100 pregnant women with no history of chronic diseases before pregnancy were included in the study. Pre-delivery maternal venous blood and neonatal cord blood samples were collected and total 25(OH)D concentration was measured. Data on vitamin D consumption (collected with the use of Food Frequency Questionnaire) and lifestyle factors were taken...
September 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28940428/maternal-alcohol-use-and-nutrition-during-pregnancy-diet-and-anthropometry
#12
R Colin Carter, Marjanne Senekal, Neil C Dodge, Lori Bechard, Ernesta M Meintjes, Christopher D Molteno, Christopher Duggan, Joseph L Jacobson, Sandra W Jacobson
BACKGROUND: Despite known risks of prenatal nutritional deficiencies and studies documenting increased prevalence of poor dietary intake among non-pregnant alcohol abusers, the nutritional status of heavy drinking pregnant women remains largely unstudied. Animal models have found interactions between prenatal ethanol exposure and micronutrients, such as choline, folate, B12, and iron, and human studies have reported that lower maternal weight and body mass confer increased fetal alcohol-related risk...
September 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28939424/maternal-early-pregnancy-vitamin-d-status-in-relation-to-low-birth-weight-and-small-for-gestational-age-offspring
#13
Huiping Wang, Yanfeng Xiao, Lan Zhang, Qiong Gao
Maternal vitamin D deficiency is an independent risk factor for fetal growth. We examined the associations between maternal vitamin D status (defined by 25-hydroxyvitamin D [25(OH)D]) at the first prenatal visit and measures of newborn and placental weight, in a large China cohort of singleton, term, live births. From July 2015 to June 2016, women delivering singleton, term, live births with 25(OH)D measured at a first prenatal visit (N=747). Birth weight, placental weight, the placental to fetal weight ratio, and small for gestational age (SGA) were measured...
September 20, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#14
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28924373/association-of-maternal-serum-25-hydroxyvitamin-d-concentrations-in-second-trimester-with-delivery-mode-in-a-chinese-population
#15
Yingdi Yuan, Heng Liu, Chenbo Ji, Xirong Guo, Lingmin Hu, Juan Wen, Manhong Cai
Objective: To determine the maternal serum 25-hydroxyvitamin D [25(OH)D] concentrations in a Chinese population and investigate its associations with subsequent delivery mode by studying 1924 unrelated pregnant women. Methods: The serum 25(OH)D concentrations was measured by euzymelinked immunosorbent assay (ELISA). Simultaneously, maternal information and subsequent delivery mode were collected. Logistic regression analysis was performed to assess the associations between 25(OH)D concentrations and caesarean section...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28923762/vitamin-d-in-asthma-mechanisms-of-action-and-considerations-for-clinical-trials
#16
REVIEW
Paul E Pfeffer, Catherine M Hawrylowicz
There is increasing interest in the therapeutic utility of vitamin D in asthma, which is supported by a significant body of evidence on epidemiologic associations between vitamin D insufficiency and worse asthma control. In support of a causal relationship, vitamin D beneficially modulates diverse immunologic pathways in heterogeneous asthma endotypes, regulating the actions of lymphocytes, mast cells, antigen-presenting cells, and structural cells to dampen excessive inflammatory responses. Allergic asthma is characterized by a failure of immune tolerance and the development of pathologic responses to inhaled aeroallergens, and vitamin D has been extensively shown to support immune regulation...
September 18, 2017: Chest
https://www.readbyqxmd.com/read/28923490/the-association-of-maternal-asthma-and-early-pregnancy-vitamin-d-with-risk-of-preeclampsia-an-observation-from-vitamin-d-antenatal-asthma-reduction-trial-vdaart
#17
Hooman Mirzakhani, Vincent J Carey, Thomas F McElrath, Nancy Laranjo, George O'Connor, Ronald E Iverson, Aviva Lee-Parritz, Robert C Strunk, Leonard B Bacharier, George A Macones, Robert S Zeiger, Michael Schatz, Bruce W Hollis, Augusto A Litonjua, Scott T Weiss
BACKGROUND: Maternal asthma, uncontrolled asthma, and low vitamin D levels during pregnancy have been individually linked to increased risk of preeclampsia. OBJECTIVE: To investigate the association of history of physician-diagnosed asthma and uncontrolled asthma status during pregnancy with the risk of preeclampsia and the effects of early pregnancy vitamin D concentrations on this relationship. METHODS: A total of 816 subjects with available pregnancy outcome data and risk factors of interest were analyzed...
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28920568/pregnant-women-of-south-asian-ethnicity-in-canada-have-substantially-lower-vitamin-b12-status-compared-with-pregnant-women-of-european-ethnicity
#18
Theresa H Schroder, Graham Sinclair, Andre Mattman, Benjamin Jung, Susan I Barr, Hilary D Vallance, Yvonne Lamers
Maternal vitamin B12 (B12) status has been inversely associated with adverse pregnancy outcomes and positively with fetal growth and infant development. South Asians, Canada's largest ethnic minority, are prone to B12 deficiency. Yet, data are lacking on B12 status in South Asian pregnant women in North America. We sought to determine B12 status, using multiple biomarkers, in 1st and 2nd trimester pregnant women of South Asian and, for comparison, European ethnicity living in Vancouver, Canada. In this retrospective cohort study, total B12, holotranscobalamin (holoTC), methylmalonic acid (MMA), and total homocysteine concentrations were quantified in two routinely collected (mean gestational week: 11·5 (range 8·3-13·9) and 16·5 (range 14·9-20·9)), banked serum samples of 748 healthy pregnant South Asian (n 371) and European (n 377) women...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28912817/the-effects-of-vitamin-d-supplement-on-prevention-of-recurrence-of-preeclampsia-in-pregnant-women-with-a-history-of-preeclampsia
#19
Sanam Behjat Sasan, Farnaz Zandvakili, Nasrin Soufizadeh, Elaheh Baybordi
INTRODUCTION: Preeclampsia is a pregnancy-specific syndrome. One of the hypotheses concerning the etiology of preeclampsia is vitamin D deficiency during pregnancy. METHOD AND MATERIALS: The present study is a randomized controlled clinical trial which aims to determine the effect of vitamin D supplement on reducing the probability of recurrent preeclampsia. 72 patients were placed in control group while 70 patients were randomized to the intervention group. The intervention group received a 50000 IU pearl vitamin D3 once every two weeks...
2017: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/28911164/response-to-letter-genetics-and-vitamin-d-supplementation-in-pregnancy
#20
Rebecca J Moon, Nicholas C Harvey, Cyrus Cooper
No abstract text is available yet for this article.
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
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