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Vitamin D in pregnancy

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https://www.readbyqxmd.com/read/28632934/a-prospective-microbiome-wide-association-study-of-food-sensitization-and-food-allergy-in-early-childhood
#1
Jessica H Savage, Kathleen A Lee-Sarwar, Joanne Sordillo, Supinda Bunyavanich, Yanjiao Zhou, George O'Connor, Megan Sandel, Leonard Bacharier, Robert Zeiger, Erica Sodergren, George M Weinstock, Diane R Gold, Scott T Weiss, Augusto A Litonjua
BACKGROUND: Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. METHODS: Intestinal microbiome samples were collected at age 3-6 months in children participating in the follow-up phase of an interventional trial of high dose Vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed...
June 20, 2017: Allergy
https://www.readbyqxmd.com/read/28625761/impact-of-vitamin-d-levels-on-ovarian-reserve-and-ovarian-response-to-ovarian-stimulation-in-oocyte-donors
#2
Alberta Maria Fabris, Maria Cruz, Carlos Iglesias, Alberto Pacheco, Azadeh Patel, Jayesh Patel, Human Fatemi, Juan Antonio García-Velasco
Recently, growing interest in vitamin D has emerged from findings that demonstrate a low vitamin D status in populations. Similarly, much interest has been shown in the role that anti-Müllerian hormone (AMH) plays in reproductive physiology. Considerable confusion as to whether vitamin D status is related to ovarian function can be found in the literature. Our retrospective study was performed from June 2014 to April 2015. Oocyte donors were recruited and stimulated under the antagonist protocol with gonadotrophin-releasing hormone (GnRH) agonist to trigger ovulation...
May 19, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28625206/organic-food-consumption-during-pregnancy-and-its-association-with-health-related-characteristics-the-koala-birth-cohort-study
#3
Ana Paula Simões-Wüst, Carolina Moltó-Puigmartí, Eugene Hjm Jansen, Martien Cjm van Dongen, Pieter C Dagnelie, Carel Thijs
OBJECTIVE: To investigate the associations of organic food consumption with maternal pre-pregnancy BMI, hypertension and diabetes in pregnancy, and several blood biomarkers of pregnant women. DESIGN: Prospective cohort study. SETTING: Pregnant women were recruited at midwives' practices and through channels related to consumption of food from organic origin. SUBJECTS: Pregnant women who filled in FFQ and donated a blood sample (n 1339)...
June 19, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28622535/vitamin-d-mediates-the-relationship-between-placental-cathelicidin-and-group-b-streptococcus-colonization-during-pregnancy
#4
Christine C Akoh, Eva K Pressman, Corrie M Whisner, Carrie Thomas, Chang Cao, Tera Kent, Elizabeth Cooper, Kimberly O O'Brien
Vitamin D is thought to modulate innate immune responses, and recent studies have highlighted the autocrine and paracrine functions of vitamin D in the placenta. Our objective was to determine the relationship between maternal vitamin D status and placental antimicrobial peptide (AMP) expression in a group of racially and ethnically diverse pregnant adolescents. In this study, 158 pregnant adolescents were recruited from the Rochester Adolescent Maternity Program (RAMP) in Rochester, NY. Maternal serum concentrations of the vitamin D biomarkers, 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D), were measured at mid-gestation (∼26 weeks) and at delivery...
June 6, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28620575/osteoporosis-management-in-ankylosing-spondylitis
#5
Alicia M Hinze, Grant H Louie
Low bone mineral density (BMD) is increasingly recognized as a common comorbid condition in ankylosing spondylitis (AS). As low BMD increases fracture risk, it is important to identify and treat low BMD in patients with AS who have been shown to be at increased risk for fractures above the population normal. Since low BMD occurs early in disease, we screen during the first year of diagnosis with dual energy x-ray absorptiometry (DXA). If patients are found to have osteoporosis by T-score of less than -2.5 or if their Z-score on DXA is more than two standard deviations below the mean, we initiate therapy with bisphosphonates in males and in females who are not planning any future pregnancies...
December 2016: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28620423/vitamin-d-in-pregnancy-current-perspectives-and-future-directions
#6
REVIEW
Mairead Kiely, Andrea Hemmingway, Karen M O'Callaghan
As neonatal vitamin D status is determined by circulating maternal 25-hydroxyvitamin D [25(OH)D] concentrations, prevention of maternal vitamin D deficiency during pregnancy is essential for the avoidance of neonatal deficiency. However, a high prevalence of vitamin D deficiency has been extensively reported among gravidae and neonates from ethnic minorities and white populations resident at high latitude. Currently, regulatory authorities recommend vitamin D intakes for pregnant women that are similar to non-pregnant adults of the same age, at 10-15 µg/day (400-600 IU), to meet 25(OH)D thresholds of 25-50 nmol/liter...
June 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28619429/vitamin-d-and-multiple-sclerosis-an-update
#7
REVIEW
Charles Pierrot-Deseilligny, Jean-Claude Souberbielle
The most recent findings linking exposure to sun and vitamin D insufficiency to multiple sclerosis (MS) are reviewed. Due to insufficient sunshine and changing lifestyles, hypovitaminosis D is widespread in temperate countries. Numerous epidemiological studies have strongly suggested that sunshine and vitamin D insufficiency contributes to MS risk in these countries. Moreover, several large genetic studies in MS patients have recently stated unequivocally that diverse abnormalities involving vitamin D metabolism are related to the risk of the disease...
May 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28618852/low-vitamin-d-is-associated-with-infections-and-proinflammatory-cytokines-during-pregnancy
#8
Christine C Akoh, Eva K Pressman, Elizabeth Cooper, Ruth Anne Queenan, Julie Pillittere, Kimberly O O'Brien
Vitamin D is known to regulate innate and adaptive immune processes at the cellular level, but the role of vitamin D status on associated inflammatory processes across pregnancy is unclear. Our primary objective was to evaluate the relationships between serum biomarkers of inflammation (interleukin [IL]-6, IL-10, tumor necrosis factor [TNF]-α), acute-phase proteins (C-reactive protein and hepcidin) and vitamin D status, 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D (1,25(OH)2D), measured across pregnancy and in the neonate at birth...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28615379/daily-consumption-of-lipid-based-nutrient-supplements-containing-250-%C3%AE-g-iodine-does-not-increase-urinary-iodine-concentrations-in-pregnant-and-postpartum-women-in-bangladesh
#9
Malay K Mridha, Susana L Matias, Rina Rani Paul, Sohrab Hussain, Md Showkat Ali Khan, Zakia Siddiqui, Barkat Ullah, Mostofa Sarker, Mokbul Hossain, Rebecca T Young, Charles D Arnold, Kathryn G Dewey
Background: Maternal iodine deficiency during pregnancy and lactation is common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on urinary iodine concentration (UIC).Methods: We conducted a cluster-randomized controlled effectiveness trial in which we enrolled 4011 pregnant women at ≤20 gestational weeks. Women in 48 clusters received iron and folic acid (IFA; 60 mg Fe/d + 400 μg folic acid/d) and women in 16 clusters received LNS-PL (20 g/d, 118 kcal) containing 22 vitamins and minerals (including 250 μg I)...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28615265/adequacy-of-nutritional-intake-from-food-and-supplements-in-a-cohort-of-pregnant-women-in-qu%C3%A3-bec-canada-the-3d-cohort-study-design-develop-discover
#10
Lise Dubois, Maikol Diasparra, Brigitte Bédard, Cynthia K Colapinto, Bénédicte Fontaine-Bisson, Anne-Sophie Morisset, Richard E Tremblay, William D Fraser
Background: Assessments of the dietary intakes in various populations suggest that pregnant women have difficulty meeting all their nutritional requirements through diet alone. Few large-scale studies have considered both food sources and supplements in assessing the adequacy of nutritional intakes during pregnancy.Objectives: Our study aimed to assess nutritional intakes during pregnancy by examining dietary sources and supplements. It then compared these findings with Dietary Reference Intakes.Design: We conducted a nutrition study in a large pregnancy cohort using a 3-d food record during the second trimester of pregnancy...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28612338/nutritional-rickets-and-osteomalacia-in-the-twenty-first-century-revised-concepts-public-health-and-prevention-strategies
#11
REVIEW
Suma Uday, Wolfgang Högler
PURPOSE OF REVIEW: Nutritional rickets and osteomalacia are common in dark-skinned and migrant populations. Their global incidence is rising due to changing population demographics, failing prevention policies and missing implementation strategies. The calcium deprivation spectrum has hypocalcaemic (seizures, tetany and dilated cardiomyopathy) and late hypophosphataemic (rickets, osteomalacia and muscle weakness) complications. This article reviews sustainable prevention strategies and identifies areas for future research...
June 13, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28612095/maternal-fetal-vitamin-d-receptor-polymorphisms-significantly-associated-with-preterm-birth
#12
Talya Rosenfeld, Hagit Salem, Gheona Altarescu, Sorina Grisaru-Granovsky, Aharon Tevet, Ruth Birk
PURPOSE: Preterm birth (PTB) is a complex trait with strong genetic background, whose etiology is not fully understood. It was recently suggested that pregnancy duration is affected by fetal genetic variation even more than by the maternal genome. Vitamin D receptor (VDR) is involved in embryonic implantation and fertility. We studied the association between both maternal and neonatal vitamin D receptor (VDR) genetic variation and PTB. METHODS: Maternal and fetal (umbilical cord) DNA was isolated from Jewish Israeli idiopathic preterm newborns (24-36 weeks, n = 146) and control term newborns (>37 weeks, n = 229)...
June 13, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28608585/effect-of-dietary-conjugated-linoleic-acid-on-vitamin-a-status-of-lactating-rats-and-their-offspring
#13
J O Zeitz, E Most, K Eder
The absorption and metabolism of vitamin A is linked with that of lipids. It is known that conjugated linoleic acid (CLA) affects the lipid metabolism in growing and lactating animals. In the present study, the hypothesis was investigated that dietary CLA influences vitamin A status of lactating rats and their pups during the suckling period. For this purpose, Wistar Han rats were fed either a control diet (control group, n = 14) or a diet containing 0.87% of cis-9, trans-11 and trans-10, cis-12 (1:1) CLA (CLA group, n = 14) during pregnancy and lactation...
June 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28606587/asthma-control-status-in-pregnancy-bmi-and-maternal-vitamin-d-levels
#14
Hooman Mirzakhani, George O'Connor, Leonard B Bacharier, Robert S Zeiger, Michael X Schatz, Scott T Weiss, Augusto A Litonjua
Higher maternal 25OHD levels at early pregnancy could reduce the associated risk of uncontrolled asthma status during pregnancy. Obesity might attenuate this effect and is a predictor of uncontrolled status during pregnancy.
June 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28601865/neonatal-vitamin-d-levels-in-relation-to-risk-of-overweight-at-7-years-in-the-danish-d-tect-case-cohort-study
#15
Camilla B Jensen, Marika Lundqvist, Thorkild I A Sørensen, Berit L Heitmann
BACKGROUND: Vitamin D level in pregnancy may be associated with risk of overweight in the offspring later in life. METHODS: In a case-cohort study based on Danish biobanks and registers we examined the association between 25-hydroxy-vitamin D (25(OH)D) level at birth and overweight at 7 years. Cases of overweight (n = 871) were randomly selected among 7-year-old children from the Copenhagen School Health Records Register (CSHRR) with a BMI above the 90th percentile...
June 10, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28598004/higher-maternal-vitamin-d-concentrations-are-associated-with-longer-leukocyte-telomeres-in-newborns
#16
Jung-Ha Kim, Gwang Jun Kim, Donghee Lee, Jae-Hong Ko, Inja Lim, Hyoweon Bang, Bart W Koes, Byeongchan Seong, Duk-Chul Lee
Gestational vitamin D insufficiency is related with increased risks of various diseases and poor health outcomes later in life. Telomere length at birth or early in life is known to be a predictor of individual health. Both vitamin D and telomere length are related with various health conditions, and vitamin D concentrations are associated with leukocyte telomere lengths in women. We investigated the association between maternal vitamin D concentrations and newborn leukocyte telomere lengths. This cross-sectional study included 106 healthy pregnant women without adverse obstetric outcomes and their offspring...
June 9, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28596717/integration-of-metabolomic-and-transcriptomic-networks-in-pregnant-women-reveals-biological-pathways-and-predictive-signatures-associated-with-preeclampsia
#17
Rachel S Kelly, Damien C Croteau-Chonka, Amber Dahlin, Hooman Mirzakhani, Ann C Wu, Emily S Wan, Michael J McGeachie, Weiliang Qiu, Joanne E Sordillo, Amal Al-Garawi, Kathryn J Gray, Thomas F McElrath, Vincent J Carey, Clary B Clish, Augusto A Litonjua, Scott T Weiss, Jessica A Lasky-Su
INTRODUCTION: Preeclampsia is a leading cause of maternal and fetal mortality worldwide, yet its exact pathogenesis remains elusive. OBJECTIVES: This study, nested within the Vitamin D Antenatal Asthma Reduction Trial (VDAART), aimed to develop integrated omics models of preeclampsia that have utility in both prediction and in the elucidation of underlying biological mechanisms. METHODS: Metabolomic profiling was performed on first trimester plasma samples of 47 pregnant women from VDAART who subsequently developed preeclampsia and 62 controls with healthy pregnancies, using liquid-chromatography tandem mass-spectrometry...
January 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28593917/vitamin-d-deficiency-in-pregnancy-at-term-risk-factors-and-pregnancy-outcomes
#18
Chui Ling Lee, Beng Kwang Ng, Loo Ling Wu, Fook Choe Cheah, Hanita Othman, Nor Azlin Mohamed Ismail
Background Vitamin D deficiency during pregnancy is a worldwide epidemic. The aim of this study was to determine the prevalence of vitamin D deficiency, its predictive factors and the association with pregnancy outcomes. Materials and methods This was a prospective observational study in a tertiary teaching hospital over 2-years' duration from August 2013 to August 2015. A total of 680 women who completed 37 weeks of pregnancy were recruited. Results Five hundred and seventy-five patients were enrolled in the final analysis for pregnancy outcomes (response rate of 84...
May 26, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28592609/tracking-of-vitamin-d-status-from-childhood-to-early-adulthood-and-its-association-with-peak-bone-mass
#19
Kun Zhu, Wendy H Oddy, Patrick Holt, Wendy Chan She Ping-Delfos, Jenny Mountain, Stephen Lye, Craig Pennell, Prue H Hart, John P Walsh
Background: To our knowledge, there are few longitudinal studies of vitamin D status from childhood to early adulthood, and it is uncertain whether vitamin D predicts peak bone mass in young adults.Objectives: The purpose of this longitudinal study was to evaluate the long-term stability of vitamin D status from ages 6 to 20 y in healthy individuals and to study associations between serum 25-hydroxyvitamin D [25(OH)D] at different developmental stages and bone mass measured at age 20 y.Design: Participants were offspring of the Western Australian Pregnancy Cohort (Raine) study...
June 7, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28590567/vitamin-d-insufficiency-preterm-delivery-and-preeclampsia-in-women-with-type-1-diabetes-an-observational-study
#20
Marianne Vestgaard, Anna L Secher, Lene Ringholm, Jens-Erik Beck Jensen, Peter Damm, Elisabeth R Mathiesen
INTRODUCTION: The aim was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women with type 1 diabetes. MATERIAL AND METHODS: An observational study of 198 pregnant women with type 1 diabetes. 25-Hydroxy-Vitamin D and HbA1c were measured in blood samples in early (median 8 weeks, range 5-14) and late (34 weeks, 32-36) pregnancy. Kidney involvement (microalbuminuria or nephropathy) at inclusion, smoking status at inclusion, preterm delivery (<37 weeks) and preeclampsia (blood pressure ≥140/90 mmHg and proteinuria) were registered...
June 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
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